1. WHO manual for the standardized investigation and diagnosis of the infertile couple. WHO. 3-th ed. Cambridge universiti press, 2000.
2. Сухих Г.Т., Божедомов В.А. Мужское бесплодие. Учебное пособие для системы послевузовского профессионального образования врачей по специальностям «урология» и «акушерство и гинекология». М.: Эксмо.
3. Nieschlag E, Behre HM, Nieschlag S. Andrology. Male Reproductive Health and Disfunction. Springer, 2010.
4. Dohle GR, Diemrr T, Giwercman A et al. Guidelines on male infertility. Europen Association of Urology, 2011.
5 Божедомов В.А., Громенко Д.С., Ушакова И.В. и др. Причины оксидативного стресса сперматозоидов. Проблемы репродукции. 2008; 6: 67–73.
6. Божедомов В.А., Громенко Д.С., Ушакова И.В. и др. Оксидативный стресс сперматозоидов в патогенезе мужского бесплодия. Урология. 2009; 2: 51–6.
7. Божедомов В.А., Николаева М.А., Ушакова И.В. и др. Роль процессов свободно-радикального окисления в патогенезе мужского иммунного бесплодия. Андрология и генитальная хирургия. 2010; 4: 62–6.
8. Agarwal A, Prabakaran S, Allamaneni S. What an andrologist/urologist should know about free radicals and why. Urology 2006; 67: 2–8.
9. Athayde KS, Cocuzza M, Agarwal A et al. Development of normal reference values for seminal reactive oxygen species and their correlation with leukocytes and semen parameters in a fertile population. J Androl 2007; 28: 613–20.
10. Tremellen K. Oxidative stress and male infertility – a clinical perspective. Hum Reprod Update 2008; 14 (3): 243–58.
11. Zini A, Al-Hathal N. Antioxidant therapy in male infertility: fact or fiction? Asian J Androl 2011; 13 (3): 374–81.
12. Lombardo F, Sansone A, Romanelli F et al.The role of antioxidant therapy in the treatment of male infertility: an overview. Asian J Androl 2011; 10.1038/aja.2010.183.
13. Fujii J, Tsunoda S. Redox regulation of fertilisation and the spermatogenic process. Asian J Androl 2011; 13 (3): 420–3.
14. Aitken RJ, Gordon E, Harkiss D et al. Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa. Biol Reprod 1998; 59: 1037–46.
15. Sheriff DS, Ali EF. Perspective on plasma membrane cholesterol efflux and spermatozoal function. J Hum Reprod Sci 2010; 3 (2): 68–75.
16. Jones R, Mann T, Sherins R. Peroxidative breakdown of phospholipids in human spermatozoa, spemicidal properties of fatty acid peroxides, and protective action of seminal plasma. Fertil Steril 1979; 31: 531–7.
17. Aitken RJ, Clarkson JS, Fishel S. Generation of reactive oxygen species, lipid peroxidation, and human sperm function. Biol Reprod 1989; 41: 183–97.
18. Zorn B, Vidmar G, Meden-Vrtovec H. Seminal reactive oxygen species as predictors of fertilization, embryo quality and pregnancy rates after conventional in vitro fertilization and intracytoplasmic sperm injection. Int J Androl 2003; 26: 279–85.
19. Henkel R, Kierspel E, Stalf T et al. Effect of reactive oxygen species produced by spermatozoa and leukocytes on sperm functions in non-leukocytospermic patients. Fertil Steril 2005; 83: 635–42.
20. Kao SH, Chao HT, Chen HW et al. Increase of oxidative stress in human sperm with lower motility. Fertil Steril 2007.
21. Kemal Duru N, Morshedi M, Oehninger S. Effects of hydrogen peroxide on DNA and plasma membrane integrity of human spermatozoa. Fertil Steril 2000; 74: 1200–7.
22. Villegas J, Schulz M, Soto L et al. Influence of reactive oxygen species produced by activated leukocytes at the level of apoptosis in mature human spermatozoa. Fertil Steril 2005; 83: 808–10.
23. Aitken RJ, De Juliis GN. On the possible origins of DNA damage in human spermatozoa. Mol. Hum Reprod 2010; 16 (1): 3–13.
24. Koppers AJ, Mitchell LA, Wang P et al. Phosphoinositide 3-kinase signalling pathway involvement in a truncated apoptotic cascade associated with motility loss and oxidative DNA damage in human spermatozoa. Biochem J 2011; 436 (3): 687–98.
25. Loft S, Kold-Jensen T, Hjollund NH et al. Oxidative DNA damage in human sperm influences time to pregnancy. Hum Reprod 2003; 18: 1265–72.
26. Meseguer M, de los Santos MJ, Simon C et al. Effect of sperm glutathione peroxidases 1 and 4 on embryo asymmetry and blastocyst quality in oocyte donation cycles. Fertil Steril 2006; 86: 1376–85.
27. Lenzi A, Culasso F, Gandini L et al. Placebo-controlled, double-blind, cross-over trial of glutathione therapy in male infertility. Hum Reprod 1993; 8: 1657–62.
28. Lenzi A, Sgro P, Salacone P et al. A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia. Fertil Steril 2004; 81: 1578–84.
29. Keskes-Ammar L, Feki-Chakroun N, Rebai T et al. Sperm oxidative stress and the effect of an oral vitamin E and selenium supplement on semen quality in infertile men. Arch Androl 2003; 49: 83–94.
30. Balercia G, Regoli F, Armeni T et al. Placebo-controlled double-blind randomized trial on the use of L-carnitine, L-acetylcarnitine, or combined L-carnitine and L-acetylcarnitine in men with idiopathic asthenozoospermia. Fertil Steril 2005; 84: 662–71.
31. Aitken RJ, Krausz C. Oxidative stress, DNA damage and the Y chromosome. Reproduction 2001; 122: 497–506.
32. De JongCJ, Barratt CLR. The Sperm Cell: Production, maturation, fertilization, regeneration. Cambridge University Press, 2006.
33. Gomez E, Aitken J. Impact of in vitro fertilization culture media on peroxidative damage to human spermatozoa. Fertil Steril 1996; 65: 880–2.
34. Garrido N, Meseguer M, Alvarez J et al. Relationship among standard semen parameters, glutathione peroxidase/glutathione reductase activity, and mRNA expression and reduced glutathione content in ejaculated spermatozoa from fertile and infertile men. Fertil Steril 2004; 82 (Suppl. 3): 1059–66.
35. Plante M, de Lamirande E, Gagnon C. Reactive oxygen species released by activated neutrophils, but not by deficient spermatozoa, are sufficient to affect normal sperm motility. Fertil Steril 1994; 62: 387–93.
36. Henkel R, Kierspel E, Stalf T et al. Effect of reactive oxygen species produced by spermatozoa and leukocytes on sperm functions in non-leukocytospermic patients. Fertil Steril 2005; 83: 635–42.
37. Fujii J, Iuchi Y, Matsuki S, Ishii T. Cooperative function of antioxidant and redox systems against oxidative stress in male reproductive tissues. Asian J Androl 2003; 5: 231–42.
38. Garrido N, Meseguer M, Simon C et al. Pro-oxidative and anti-oxidative imbalance in human semen and its relation with male fertility. Asian J Androl 2004; 6: 59–65.
39. Zelen I, Mitrović M, Jurisic-Skevin A, Arsenijević S. Activity of superoxide dismutase and catalase and content of malondialdehyde in seminal plasma of infertile patients. Med Pregl 2010; 63 (9–10): 624–9.
40. Rhemrev JP, van Overveld FW, Haenen GR et al. Quantification of the nonenzymatic fast and slow TRAP in a postaddition assay in human seminal plasma and the antioxidant contributions of various seminal compounds. J Androl 2000; 21 (6): 913–20.
41. Perez-Crespo M, Pintado B, Gutierrez-Adan A. Scrotal heat stress effects on sperm viability, sperm DNA integrity, and the offspring sex ratio in mice. Mol Reprod Dev 2007; 75: 40–7.
42. Sarkar O, Bahrainwala J, Chandrasekaran S et al. Impact of inflammation on male fertility. Front Biosci (Elite Ed) 2011; 3: 89–95.
43. Eisenberg ML, Lipshultz LI. Varicocele-induced infertility: Newer insights into its pathophysiology. Indian J Urol 2011; 27 (1): 58–64.
44. WHO laboratory manual for the examination and processing of human semen. Fifth edition, 2010; p. 142–6.
45. Aitken RJ et al. Shadding light on chemiluminescence: the application of chemiluminescence in diagnostic andrology. J Androl 2004; 25: 455–65.
46. Agarwal A, Nallella KP, Allamaneni SS, Said TM. Role of antioxidants in treatment of male infertility: an overview of the literature. Reprod Biomed Online 2004; 8: 616–27.
47. Lanzafame FM, La Vignera S, Vicari E, Calogero AE. Oxidative stress and medical antioxidant treatment in male infertility. Reprod Biomed Online 2009; 19 (5): 638–59.
48. Сивков А.В., Ощепков В.Н., Евдокимов В.В. и др. Эффективность и безопасность препарата Селцинк Плюс у пациентов с хроническим неинфекционным простатитом и нарушениями фертильности. Экспериментальная и клиническая урология. 2010; 1 (2).
1. ФГБУ Первая поликлиника Управления делами президента РФ, Москва;
2. Кафедра акушерства, гинекологии, перинатологии и репродуктологии ФППОВ ГБОУ ВПО Первый МГМУ
им. И.М.Сеченова;
3. Кафедра клинической андрологии ФПКМР РУДН, Москва