Влияние иммунорегуляторных свойств семенной плазмы на репродуктивную функцию женщин

1. Robertson SA, Ingman WV, O’Leary S et al. Transforming growth factor beta-a mediator of immune deviation in seminal plasma. J Reprod Immunol 2002; 57: 109–28.
2. Robertson SA, Guerin LR, Bromfield JJ et al. Seminal fluid drives expansion of the CD4+CD25+ T regulatory cell pool and induces tolerance to paternal alloantigens in mice. Biol Reprod 2009; 80 (5): 1036–45.
3. Zenclussen AC, Gerlof K, Zenclussen ML et al. Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells pre- vents fetal rejection in a murine abortion model. Am J Pathol 2005; 166: 811–22.
4. Robertson SA. Seminal plasma and male factor signalling in the female reproductive tract. Cell Tissue Res 2005; 322: 43–52.
5. O'Leary S, Jasper MJ, Warnes GM et al. Seminal plasma regulates endometrial cytokine expression, leukocyte recruitment and embryo development in the pig. Reproduction 2004; 128 (2): 237–47.
6. Burnham K, Robb L, Scott CL et al. Effect of granulocyte-macrophage colony-stimulating factor on the generation of epidermal Langerhans cells. J Interferon Cytokine Res 2000; 20: 1071–6.
7. Hubert P, van den Brule F, Giannini SL et al. Colonization of in vitro-formed cervical human papillomavirus- associated (pre)neoplastic lesions with dendritic cells: role of granulocyte/macrophage colony-stimulating factor. Am J Pathol 1999; 154: 775–84.
8. Robertson SA. Control of the immunological environment of the uterus. Rev Reprod 2000; 5: 164–74.
9. Diehl S, Rincon M. The two faces of IL-6 on Th1/Th2 differentiation. Mol Immunol 2002; 39: 531–6.
10. Gutsche S, von Wolff M, Strowitzki T, Thaler CJ. Seminal plasma induces mRNA expression of IL-1beta, IL-6 and LIF in endometrial epithelial cells in vitro. Mol Hum Reprod 2003; 9: 12: 785–91.
11. Sharkey DJ, M.Macpherson A, Tremellen KP, Robertson SA. Seminal plasma differentially regulates inflammatory cytokine gene expression in human cervical and vaginal epithelial cells. Mol Hum Reprod 2007; 13 (7): 491–501.
12. Pandya IJ, Cohen J. The leukocytic reaction of the human uterine cervix to spermatozoa. Fertil Steril 1985; 43 (3): 417–21.
13. Thompson LA et al. The leukocytic reaction of the human uterine cervix. Am J Reprod Immunol 1992; 28 (2): 85–9.
14. Tremellen KP, Seamark RF, Robertson SA. Seminal transforming growth factor ß1 stimulates granulocyte-macrophage colony-stimulating factor production and inflammatory cell recruitment in the murine uterus. Biol Reprod 1998; 58: 1217–25.
15. Johansson M, Bromfield JJ, Jasper MJ, Robertson SA. Semen activates the female immune response during early pregnancy in mice. Immunology 2004; 112: 290–300.
16. Pandya IJ, Cohen J. The leukocytic reaction of the human cervix to spermatozoa. Fertil Steril 1985; 43: 417–21.
17. Robertson SA, Mau VJ, Tremellen KP, Seamark RF. Role of high molecular weight seminal vesicle proteins in eliciting the uterine inflammatory response to semen in mice. J Reprod Fertil 1996; 107: 265–77.
18. Kimber SJ. Leukaemia inhibitory factor in implantation and uterine biology. Reproduction 2005; 130: 131–45.
19. Wolff M, Rösner S, Thöne C et al. Intravaginal and intracervical application of seminal plasma in in vitro fertilization or intracytoplasmic sperm injection treatment cycles – a double-blind, placebo-controlled, randomized pilot study. Fertil Steril 2009; 91 (1): 167–72. Epub 2008.
20. Bellinge BS, Copeland CM, Thomas TD et al. The influence of patient insemination on the implantation rate in an in vitro fertilization and embryo transfer program. Fertil Steril 1986; 46 (2): 252–6.
21. Tremellen KP, Valbuena D, Landers J et al. The effect of intercourse on pregnancy rates during assisted human reproduction. Hum Reprod 2000; 15 (12): 2653–8.

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1. Robertson SA, Ingman WV, O’Leary S et al. Transforming growth factor beta-a mediator of immune deviation in seminal plasma. J Reprod Immunol 2002; 57: 109–28.
2. Robertson SA, Guerin LR, Bromfield JJ et al. Seminal fluid drives expansion of the CD4+CD25+ T regulatory cell pool and induces tolerance to paternal alloantigens in mice. Biol Reprod 2009; 80 (5): 1036–45.
3. Zenclussen AC, Gerlof K, Zenclussen ML et al. Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells pre- vents fetal rejection in a murine abortion model. Am J Pathol 2005; 166: 811–22.
4. Robertson SA. Seminal plasma and male factor signalling in the female reproductive tract. Cell Tissue Res 2005; 322: 43–52.
5. O'Leary S, Jasper MJ, Warnes GM et al. Seminal plasma regulates endometrial cytokine expression, leukocyte recruitment and embryo development in the pig. Reproduction 2004; 128 (2): 237–47.
6. Burnham K, Robb L, Scott CL et al. Effect of granulocyte-macrophage colony-stimulating factor on the generation of epidermal Langerhans cells. J Interferon Cytokine Res 2000; 20: 1071–6.
7. Hubert P, van den Brule F, Giannini SL et al. Colonization of in vitro-formed cervical human papillomavirus- associated (pre)neoplastic lesions with dendritic cells: role of granulocyte/macrophage colony-stimulating factor. Am J Pathol 1999; 154: 775–84.
8. Robertson SA. Control of the immunological environment of the uterus. Rev Reprod 2000; 5: 164–74.
9. Diehl S, Rincon M. The two faces of IL-6 on Th1/Th2 differentiation. Mol Immunol 2002; 39: 531–6.
10. Gutsche S, von Wolff M, Strowitzki T, Thaler CJ. Seminal plasma induces mRNA expression of IL-1beta, IL-6 and LIF in endometrial epithelial cells in vitro. Mol Hum Reprod 2003; 9: 12: 785–91.
11. Sharkey DJ, M.Macpherson A, Tremellen KP, Robertson SA. Seminal plasma differentially regulates inflammatory cytokine gene expression in human cervical and vaginal epithelial cells. Mol Hum Reprod 2007; 13 (7): 491–501.
12. Pandya IJ, Cohen J. The leukocytic reaction of the human uterine cervix to spermatozoa. Fertil Steril 1985; 43 (3): 417–21.
13. Thompson LA et al. The leukocytic reaction of the human uterine cervix. Am J Reprod Immunol 1992; 28 (2): 85–9.
14. Tremellen KP, Seamark RF, Robertson SA. Seminal transforming growth factor ß1 stimulates granulocyte-macrophage colony-stimulating factor production and inflammatory cell recruitment in the murine uterus. Biol Reprod 1998; 58: 1217–25.
15. Johansson M, Bromfield JJ, Jasper MJ, Robertson SA. Semen activates the female immune response during early pregnancy in mice. Immunology 2004; 112: 290–300.
16. Pandya IJ, Cohen J. The leukocytic reaction of the human cervix to spermatozoa. Fertil Steril 1985; 43: 417–21.
17. Robertson SA, Mau VJ, Tremellen KP, Seamark RF. Role of high molecular weight seminal vesicle proteins in eliciting the uterine inflammatory response to semen in mice. J Reprod Fertil 1996; 107: 265–77.
18. Kimber SJ. Leukaemia inhibitory factor in implantation and uterine biology. Reproduction 2005; 130: 131–45.
19. Wolff M, Rösner S, Thöne C et al. Intravaginal and intracervical application of seminal plasma in in vitro fertilization or intracytoplasmic sperm injection treatment cycles – a double-blind, placebo-controlled, randomized pilot study. Fertil Steril 2009; 91 (1): 167–72. Epub 2008.
20. Bellinge BS, Copeland CM, Thomas TD et al. The influence of patient insemination on the implantation rate in an in vitro fertilization and embryo transfer program. Fertil Steril 1986; 46 (2): 252–6.
21. Tremellen KP, Valbuena D, Landers J et al. The effect of intercourse on pregnancy rates during assisted human reproduction. Hum Reprod 2000; 15 (12): 2653–8.

А.А.Бабаян, В.Ю.Смольникова, М.А.Николаева, Е.О.Степанова, Е.А.Калинина

ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава РФ, Москва