Представлен обзор литературных данных, в которых демонстрируются значимость дефицита магния в формировании проблем репродуктивного здоровья у женщин и широкие возможности использования препаратов магния в медицинской практике, в том числе акушерстве и гинекологии. Ключевые слова: магний, дефицит магния, репродуктивные проблемы.
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A review of published data which demonstrates the importance of magnesium deficiency in the formation of reproductive health in women and opportunities the use of magnesium preparations in medical practice, including obstetrics and gynecology. Key words: magnesium, magnesium deficiency, reproductive problems.
1. De Baaij JH, Hoenderop JG, Bindels RJ. Magnesium in man: implications for health and disease. Physiol Rev 2015; 95 (1): 1–46; doi: 10.1152/physrev.00012.2014.
2. De Baaij JH, Hoenderop JG, Bindels RJ. Regulation of magnesium balance: lessons learned from human genetic disease. Clin Kidney J 2012; 5 (Suppl. 1): i15-i24; doi: 10.1093/ndtplus/sfr164.
3. Kobayashi NI, Tanoi K. Critical Issues in the Study of Magnesium Transport Systems and Magnesium Deficiency Symptoms in Plants. Int J Mol Sci 2015; 16 (9): 23076–93; doi: 10.3390/ijms160923076.
4. Хашукоева А.З., Хлынова С.А., Хашукоева З.З., Карелина Л.А. Роль магния в жизни женщины. Лечащий врач. 2015; 3. / Khashukoeva A.Z., Khlynova S.A., Khashukoeva Z.Z., Karelina L.A. Rol' magniia v zhizni zhenshchiny. Lechashchii vrach. 2015; 3. [in Russian]
5. Barbagallo M, Belvedere M, Dominguez LJ. Magnesium homeostasis and aging. Magnes Res 2009; 22 (4): 235–46.
6. Ozturk N, Olgar Y, Aslan M, Ozdemir S. Effects of magnesium supplementation on electrophysiological remodeling of cardiac myocytes in L-NAME induced hypertensive rats. J Bioenerg Biomembr 2016.
7. Mazur A, Maier JA, Rock E et al. Magnesium and the inflammatory response: potential physiopathological implications. Arch Biochem Biophys 2007; 458 (1): 48–56.
8. Торшин И.Ю., Громова О.А. Дисплазия соединительной ткани, клеточная биология и молекулярные механизмы воздействия магния. РМЖ. 2008; 16 (4): 230–8. / Torshin I.Iu., Gromova O.A. Displaziia soedinitel'noi tkani, kletochnaia biologiia i molekuliarnye mekhanizmy vozdeistviia magniia. RMZh. 2008; 16 (4): 230–8. [in Russian]
9. Labygina AV, Suturina LV, Kolesnikova LI, Lazareva LM et al. Combined oral contraception and serum magnesium level changes. 2011 11th Seminar of the European Society of Contraception and Reproductive Health.
10. Вяткина И.С., Лабыгина А.В., Сутурина Л.В. и др. Дефицит магния и показатели тревожности у девушек-студенток. Репродуктивное здоровье детей и подростков. 2014; 55 (2): 94–9. / Viatkina I.S., Labygina A.V., Suturina L.V. i dr. Defitsit magniia i pokazateli trevozhnosti u devushek-studentok. Reproduktivnoe zdorov'e detei i podrostkov. 2014; 55 (2): 94–9. [in Russian]
11. Bertinato J, Lavergne C, Rahimi S et al. Moderately Low Magnesium Intake Impairs Growth of Lean Body Mass in Obese-Prone and Obese-Resistant Rats Fed a High-Energy Diet. Nutrients 2016; 8 (5); pii: E253; doi: 10.3390/nu8050253.
12. Nellis JC, Tufano RP, Gourin CG. Association between Magnesium Disorders and Hypocalcemia Following Thyroidectomy. Otolaryngol Head Neck Surg 2016; pii: 0194599816644594.
13. Rotter I, Kosik-Bogacka D, Dolgowska B et al. Relationship between serum magnesium concentration and metabolic and hormonal disorders in middle-aged and older men. Magnes Res 2015; 28 (3): 99–107; doi: 10.1684/mrh.2015.0391.
14. Komiya Y, Runnels LW. TRPM channels and magnesium in early embryonic development. Int J Dev Biol 2015; 59 (7–9): 281–8; doi: 10.1387/ijdb.150196lr.
15. Velissaris D, Karamouzos V, Pierrakos C et al. Hypomagnesemia in Critically Ill Sepsis Patients. J Clin Med Res 2015; 7 (12): 911–8; doi: 10.14740/jocmr2351w.
16. Tarasov EA, Blinov DV, Zimovina UV, Sandakova EA. Magnesium deficiency and stress: Issues of their relationship, diagnostic tests, and approaches to therapy. Ter Arkh 2015; 87 (9): 114–22.
17. Chutia H, Lynrah KG. Association of Serum Magnesium Deficiency with Insulin Resistance in Type 2 Diabetes Mellitus. J Lab Physicians 2015; 7 (2): 75–8; doi: 10.4103/0974-2727.163131.
18. Gommers LM, Hoenderop JG, Bindels RJ, de Baaij JH. Hypomagnesemia in Type 2 Diabetes: A Vicious Circle? Diabetes 2016; 65 (1): 3–13; doi: 10.2337/db15-1028.
19. Simental-Mendía LE, Sahebkar A, Rodríguez-Morán M, Guerrero-Romero F. A systematic review and meta-analysis of randomized controlled trials on the effects of magnesium supplementation on insulin sensitivity and glucose control. Pharmacol Res 2016; pii: S1043-6618(16)30308-5. doi: 10.1016/j.phrs.2016.06.019.
20. Allaert FA, Courau S, Forestier A. Effect of magnesium, probiotic, and vitamin food supplementation in healthy subjects with psychological stress and evaluation of a persistent effect after discontinuing intake. Panminerva medica 2016; 0031–0808.
21. Серов В.Н., Баранов И.И., Блинов Д.В. Результаты исследования дефицита магния у пациенток с гормонально-зависимыми заболеваниями. Акуш. и гинекол. 2015; 6: 91–7. / Serov V.N., Baranov I.I., Blinov D.V. Rezul'taty issledovaniia defitsita magniia u patsientok s gormonal'no-zavisimymi zabolevaniiami. Akush. i ginekol. 2015; 6: 91–7. [in Russian]
22. Моргунец О.Г., Чайка А.В., Носенко Е.Н. Уровень сывороточного магния у женщин репродуктивного возраста с перитонеальным эндометриозом и его коррекция препаратом биоэлектра магнезиум форте. Медико-социальные проблемы семьи. 2014; 19 (1): 32–5. / Morgunets O.G., Chaika A.V., Nosenko E.N. Uroven' syvorotochnogo magniia u zhenshchin reproduktivnogo vozrasta s peritoneal'nym endometriozom i ego korrektsiia preparatom bioelektra magnezium forte. Mediko-sotsial'nye problemy sem'i. 2014; 19 (1): 32–5. [in Russian]
23. Унанян А.Л., Аракелов С.Э., Полонская Л.С. Роль витаминов, минералов и антиоксидантов в патогенезе, комплексной терапии и профилактике эндометриоза. Гинекология. 2015; 2: 32–5. / Unanian A.L., Arakelov S.E., Polonskaia L.S. Rol' vitaminov, mineralov i antioksidantov v patogeneze, kompleksnoi terapii i profilaktike endometrioza. Ginekologiia. 2015; 2: 32–5. [in Russian]
24. Harris HR, Chavarro JE, Malspeis S et al. Dairy-food, calcium, magnesium, and vitamin D intake and endometriosis: a prospective cohort study. Am J Epidemiol 2013; 177 (5): 420–30; doi: 10.1093/aje/kws247.
25. Громова О.А., Торшин И.Ю., Гришина Т.Р. Метаанализ эффективности и безопасности использования линии препаратов Магне В6 в гинекологии. Гинекология. 2015; 17 (2): 85–92. / Gromova O.A., Torshin I.Iu., Grishina T.R. Metaanaliz effektivnosti i bezopasnosti ispol'zovaniia linii preparatov Magne V6 v ginekologii. Ginekologiia. 2015; 17 (2): 85–92. [in Russian]
26. Proctor ML, Murphy PA. Herbal and dietary therapies for primary and secondary dysmenorrhoea. Cochrane Database Syst Rev 2001; 3: CD002124.
27. Chacko SA, Song Y, Nathan L. Relations of Dietary Magnesium Intake to Biomarkers of Inflammation and Endothelial Dysfunction in an Ethnically Diverse Cohort of Postmenopausal Women. Diabetes Care 2010; 33 (2): 304–10.
28. Saeedian Kia A, Amani R, Cheraghian B. Erratum: The association between the risk of premenstrual syndrome and vitamin D, calcium, and magnesium status among university students: a case control study [Health Promotion Perspectives 2015, 5 (3): 225–30]. Health Promot Perspect 2016; 6 (1): 54; doi: 10.15171/hpp.2016.09.
29. Saeedian KA, Amani R, Cheraghian B. The Association between the Risk of Premenstrual Syndrome and Vitamin D, Calcium, and Magnesium Status among University Students: A Case Control Study. Health Promot Perspect 2015; 5 (3): 225–30; doi: 10.15171/hpp.2015.027.
30. Bianco V, Cestari AM, Casati D et al. Premenstrual syndrome and beyond: lifestyle, nutrition, and personal facts. Minerva Ginecol 2014; 66 (4): 365–75.
31. Chocano-Bedoya PO, Manson JE, Hankinson SE et al. Intake of selected minerals and risk of premenstrual syndrome. Am J Epidemiol 2013; 177 (10): 1118–27; doi: 10.1093/aje/kws363.
32. Ebrahimi E, Shiva Khayati Motlagh, Nemati S, Tavakoli Z. Effects of Magnesium and Vitamin B6 on the Severity of Premenstrual Syndrome Symptoms. J Caring Sci 2012; 1 (4): 183–9.
33. Fathizadeh N, Ebrahimi E, Valiani M et al. Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome. Iran J Nurs Midwifery Res 2010; 15 (Suppl. 1): 401–5.
34. Facchinetti F, Borella P, Sances G et al. Oral magnesium successfully relieves premenstrual mood changes. Obstet Gynecol 1991; 78 (2): 177–81.
35. Walker AF, de Souza MC, Vickers MF et al. Magnesium supplementation alleviates premenstrual symptoms of fluid retention. J Womens Health 1998; 7 (9): 1157–65.
36. Chiu HY, Yeh TH, Huang YC, Chen PY. Effects of Intravenous and Oral Magnesium on Reducing Migraine: A Meta-analysis of Randomized Controlled Trials. Pain Physician 2016; 19 (1): E97–112.
37. Пестрикова Т.Ю., Юрасова Е.А., Юрасов И.В. Биологическая роль дефицита магния в нарушении гомеостаза у женщин: обзор литературы. Гинекология. 2016; 18 (2): 40–4. / Pestrikova T.Iu., Iurasova E.A., Iurasov I.V. Biologicheskaia rol' defitsita magniia v narushenii gomeostaza u zhenshchin: obzor literatury. Ginekologiia. 2016; 18 (2): 40–4. [in Russian]
38. Komiya Y, Runnels LW. TRPM channels and magnesium in early embryonic development. Int J Dev Biol 2015; 59 (7–9): 281–8; doi: 10.1387/ijdb.150196lr.
39. James MF. Magnesium in obstetrics. Best Pract Res Clin Obstet Gynecol 2010; 24 (3): 327–37.
40. Duley L. Magnesium sulphate versus diazepam for eclampsia. Cochrane Database Syst Rev 2010; 12: CD000127.
41. Duley L. Magnesium sulphate and other anticonvulsants for women with pre-eclampsia. Cochrane Database Syst Rev 2010; 11: CD000025.
42. Rosner JY, Gupta M, McGill M et al. Magnesium deficiency during pregnancy in mice impairs placental size and function. Placenta 2016; 39: 87–93; doi: 10.1016/j.placenta.2016.01.009.
43. Schlegel RN, Moritz KM, Paravicini TM. Maternal hypomagnesemia alters renal function but does not program changes in the cardiovascular physiology of adult offspring. J Dev Orig Health Dis 2016; p. 1–8.
44. Гипертензивные расстройства во время беременности, в родах и послеродовом периоде. Преэклампсия. Эклампсия. Клинические рекомендации (протокол лечения). М., 2016. / Gipertenzivnye rasstroistva vo vremia beremennosti, v rodakh i poslerodovom periode. Preeklampsiia. Eklampsiia. Klinicheskie rekomendatsii (protokol lecheniia). M., 2016. [in Russian]
45. Pratt JJ, Niedle PS, Vogel JP et al. Alternative regimens of magnesium sulfate for treatment of pre-eclampsia and eclampsia: a systematic review of non-randomized studies. Acta Obstet Gynecol Scand 2015; doi: 10.1111/aogs.12807.
46. Gordon R, Magee LA, Payne B et al. Magnesium sulphate for the management of preeclampsia and eclampsia in low and middle income countries: a systematic review of tested dosing regimens. J Obstet Gynaecol Can 2014; 36 (2): 154–63.
47. Okusanya BO, Oladapo OT, Long Q et al. Clinical pharmacokinetic properties of magnesium sulphate in women with pre-eclampsia and eclampsia: a systematic review. BJOG 2015.
48. Клинические рекомендации (протокол лечения) «Организация медицинской эвакуации при преждевременных родах». М., 2015. / Klinicheskie rekomendatsii (protokol lecheniia) «Organizatsiia meditsinskoi evakuatsii pri prezhdevremennykh rodakh». M., 2015. [in Russian]
49. Клинические рекомендации (протокол лечения) «Преждевременные роды». М., 2013. / Klinicheskie rekomendatsii (protokol lecheniia) «Prezhdevremennye rody». M., 2013. [in Russian]
50. Громова О.А., Торшин И.Ю., Пронин А.В. и др. Мета-анализ эффективности и безопасности применения органических солей магния в акушерской практике. Акуш. и гинекол. 2014; 10: 33–40. / Gromova O.A., Torshin I.Iu., Pronin A.V. i dr. Meta-analiz effektivnosti i bezopasnosti primeneniia organicheskikh solei magniia v akusherskoi praktike. Akush. i ginekol. 2014; 10: 33–40. [in Russian]
51. Rotter I, Kosik-Bogacka DI, Dolgowska B et al. Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging. Environ Geochem Health 2016; 38 (3): 749–61; doi: 10.1007/s10653-015-9758-0.
52. De Baaij JH, Hoenderop JG, Bindels RJ. Magnesium in man: implications for health and disease. Physiol Rev 2015; 95 (1): 1–46; doi: 10.1152/physrev.00012.2014.
53. Maggio M, de Vita F, Lauretani F et al. The Interplay between Magnesium and Testosterone in Modulating Physical Function in Men. Int J Endocrinol 2014; 2014: 525249; doi: 10.1155/2014/525249.
54. Liang H, Miao M, Chen J et al. The Association Between Calcium, Magnesium, and Ratio of Calcium/Magnesium in Seminal Plasma and Sperm Quality. Biol Trace Elem Res 2016.
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1. De Baaij JH, Hoenderop JG, Bindels RJ. Magnesium in man: implications for health and disease. Physiol Rev 2015; 95 (1): 1–46; doi: 10.1152/physrev.00012.2014.
2. De Baaij JH, Hoenderop JG, Bindels RJ. Regulation of magnesium balance: lessons learned from human genetic disease. Clin Kidney J 2012; 5 (Suppl. 1): i15-i24; doi: 10.1093/ndtplus/sfr164.
3. Kobayashi NI, Tanoi K. Critical Issues in the Study of Magnesium Transport Systems and Magnesium Deficiency Symptoms in Plants. Int J Mol Sci 2015; 16 (9): 23076–93; doi: 10.3390/ijms160923076.
4. Khashukoeva A.Z., Khlynova S.A., Khashukoeva Z.Z., Karelina L.A. Rol' magniia v zhizni zhenshchiny. Lechashchii vrach. 2015; 3. [in Russian]
5. Barbagallo M, Belvedere M, Dominguez LJ. Magnesium homeostasis and aging. Magnes Res 2009; 22 (4): 235–46.
6. Ozturk N, Olgar Y, Aslan M, Ozdemir S. Effects of magnesium supplementation on electrophysiological remodeling of cardiac myocytes in L-NAME induced hypertensive rats. J Bioenerg Biomembr 2016.
7. Mazur A, Maier JA, Rock E et al. Magnesium and the inflammatory response: potential physiopathological implications. Arch Biochem Biophys 2007; 458 (1): 48–56.
8. Torshin I.Iu., Gromova O.A. Displaziia soedinitel'noi tkani, kletochnaia biologiia i molekuliarnye mekhanizmy vozdeistviia magniia. RMZh. 2008; 16 (4): 230–8. [in Russian]
9. Labygina AV, Suturina LV, Kolesnikova LI, Lazareva LM et al. Combined oral contraception and serum magnesium level changes. 2011 11th Seminar of the European Society of Contraception and Reproductive Health.
10. Viatkina I.S., Labygina A.V., Suturina L.V. i dr. Defitsit magniia i pokazateli trevozhnosti u devushek-studentok. Reproduktivnoe zdorov'e detei i podrostkov. 2014; 55 (2): 94–9. [in Russian]
11. Bertinato J, Lavergne C, Rahimi S et al. Moderately Low Magnesium Intake Impairs Growth of Lean Body Mass in Obese-Prone and Obese-Resistant Rats Fed a High-Energy Diet. Nutrients 2016; 8 (5); pii: E253; doi: 10.3390/nu8050253.
12. Nellis JC, Tufano RP, Gourin CG. Association between Magnesium Disorders and Hypocalcemia Following Thyroidectomy. Otolaryngol Head Neck Surg 2016; pii: 0194599816644594.
13. Rotter I, Kosik-Bogacka D, Dolgowska B et al. Relationship between serum magnesium concentration and metabolic and hormonal disorders in middle-aged and older men. Magnes Res 2015; 28 (3): 99–107; doi: 10.1684/mrh.2015.0391.
14. Komiya Y, Runnels LW. TRPM channels and magnesium in early embryonic development. Int J Dev Biol 2015; 59 (7–9): 281–8; doi: 10.1387/ijdb.150196lr.
15. Velissaris D, Karamouzos V, Pierrakos C et al. Hypomagnesemia in Critically Ill Sepsis Patients. J Clin Med Res 2015; 7 (12): 911–8; doi: 10.14740/jocmr2351w.
16. Tarasov EA, Blinov DV, Zimovina UV, Sandakova EA. Magnesium deficiency and stress: Issues of their relationship, diagnostic tests, and approaches to therapy. Ter Arkh 2015; 87 (9): 114–22.
17. Chutia H, Lynrah KG. Association of Serum Magnesium Deficiency with Insulin Resistance in Type 2 Diabetes Mellitus. J Lab Physicians 2015; 7 (2): 75–8; doi: 10.4103/0974-2727.163131.
18. Gommers LM, Hoenderop JG, Bindels RJ, de Baaij JH. Hypomagnesemia in Type 2 Diabetes: A Vicious Circle? Diabetes 2016; 65 (1): 3–13; doi: 10.2337/db15-1028.
19. Simental-Mendía LE, Sahebkar A, Rodríguez-Morán M, Guerrero-Romero F. A systematic review and meta-analysis of randomized controlled trials on the effects of magnesium supplementation on insulin sensitivity and glucose control. Pharmacol Res 2016; pii: S1043-6618(16)30308-5. doi: 10.1016/j.phrs.2016.06.019.
20. Allaert FA, Courau S, Forestier A. Effect of magnesium, probiotic, and vitamin food supplementation in healthy subjects with psychological stress and evaluation of a persistent effect after discontinuing intake. Panminerva medica 2016; 0031–0808.
21. Serov V.N., Baranov I.I., Blinov D.V. Rezul'taty issledovaniia defitsita magniia u patsientok s gormonal'no-zavisimymi zabolevaniiami. Akush. i ginekol. 2015; 6: 91–7. [in Russian]
22. Morgunets O.G., Chaika A.V., Nosenko E.N. Uroven' syvorotochnogo magniia u zhenshchin reproduktivnogo vozrasta s peritoneal'nym endometriozom i ego korrektsiia preparatom bioelektra magnezium forte. Mediko-sotsial'nye problemy sem'i. 2014; 19 (1): 32–5. [in Russian]
23. Unanian A.L., Arakelov S.E., Polonskaia L.S. Rol' vitaminov, mineralov i antioksidantov v patogeneze, kompleksnoi terapii i profilaktike endometrioza. Ginekologiia. 2015; 2: 32–5. [in Russian]
24. Harris HR, Chavarro JE, Malspeis S et al. Dairy-food, calcium, magnesium, and vitamin D intake and endometriosis: a prospective cohort study. Am J Epidemiol 2013; 177 (5): 420–30; doi: 10.1093/aje/kws247.
25. Gromova O.A., Torshin I.Iu., Grishina T.R. Metaanaliz effektivnosti i bezopasnosti ispol'zovaniia linii preparatov Magne V6 v ginekologii. Ginekologiia. 2015; 17 (2): 85–92. [in Russian]
26. Proctor ML, Murphy PA. Herbal and dietary therapies for primary and secondary dysmenorrhoea. Cochrane Database Syst Rev 2001; 3: CD002124.
27. Chacko SA, Song Y, Nathan L. Relations of Dietary Magnesium Intake to Biomarkers of Inflammation and Endothelial Dysfunction in an Ethnically Diverse Cohort of Postmenopausal Women. Diabetes Care 2010; 33 (2): 304–10.
28. Saeedian Kia A, Amani R, Cheraghian B. Erratum: The association between the risk of premenstrual syndrome and vitamin D, calcium, and magnesium status among university students: a case control study [Health Promotion Perspectives 2015, 5 (3): 225–30]. Health Promot Perspect 2016; 6 (1): 54; doi: 10.15171/hpp.2016.09.
29. Saeedian KA, Amani R, Cheraghian B. The Association between the Risk of Premenstrual Syndrome and Vitamin D, Calcium, and Magnesium Status among University Students: A Case Control Study. Health Promot Perspect 2015; 5 (3): 225–30; doi: 10.15171/hpp.2015.027.
30. Bianco V, Cestari AM, Casati D et al. Premenstrual syndrome and beyond: lifestyle, nutrition, and personal facts. Minerva Ginecol 2014; 66 (4): 365–75.
31. Chocano-Bedoya PO, Manson JE, Hankinson SE et al. Intake of selected minerals and risk of premenstrual syndrome. Am J Epidemiol 2013; 177 (10): 1118–27; doi: 10.1093/aje/kws363.
32. Ebrahimi E, Shiva Khayati Motlagh, Nemati S, Tavakoli Z. Effects of Magnesium and Vitamin B6 on the Severity of Premenstrual Syndrome Symptoms. J Caring Sci 2012; 1 (4): 183–9.
33. Fathizadeh N, Ebrahimi E, Valiani M et al. Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome. Iran J Nurs Midwifery Res 2010; 15 (Suppl. 1): 401–5.
34. Facchinetti F, Borella P, Sances G et al. Oral magnesium successfully relieves premenstrual mood changes. Obstet Gynecol 1991; 78 (2): 177–81.
35. Walker AF, de Souza MC, Vickers MF et al. Magnesium supplementation alleviates premenstrual symptoms of fluid retention. J Womens Health 1998; 7 (9): 1157–65.
36. Chiu HY, Yeh TH, Huang YC, Chen PY. Effects of Intravenous and Oral Magnesium on Reducing Migraine: A Meta-analysis of Randomized Controlled Trials. Pain Physician 2016; 19 (1): E97–112.
37. Pestrikova T.Iu., Iurasova E.A., Iurasov I.V. Biologicheskaia rol' defitsita magniia v narushenii gomeostaza u zhenshchin: obzor literatury. Ginekologiia. 2016; 18 (2): 40–4. [in Russian]
38. Komiya Y, Runnels LW. TRPM channels and magnesium in early embryonic development. Int J Dev Biol 2015; 59 (7–9): 281–8; doi: 10.1387/ijdb.150196lr.
39. James MF. Magnesium in obstetrics. Best Pract Res Clin Obstet Gynecol 2010; 24 (3): 327–37.
40. Duley L. Magnesium sulphate versus diazepam for eclampsia. Cochrane Database Syst Rev 2010; 12: CD000127.
41. Duley L. Magnesium sulphate and other anticonvulsants for women with pre-eclampsia. Cochrane Database Syst Rev 2010; 11: CD000025.
42. Rosner JY, Gupta M, McGill M et al. Magnesium deficiency during pregnancy in mice impairs placental size and function. Placenta 2016; 39: 87–93; doi: 10.1016/j.placenta.2016.01.009.
43. Schlegel RN, Moritz KM, Paravicini TM. Maternal hypomagnesemia alters renal function but does not program changes in the cardiovascular physiology of adult offspring. J Dev Orig Health Dis 2016; p. 1–8.
44. Gipertenzivnye rasstroistva vo vremia beremennosti, v rodakh i poslerodovom periode. Preeklampsiia. Eklampsiia. Klinicheskie rekomendatsii (protokol lecheniia). M., 2016. [in Russian]
45. Pratt JJ, Niedle PS, Vogel JP et al. Alternative regimens of magnesium sulfate for treatment of pre-eclampsia and eclampsia: a systematic review of non-randomized studies. Acta Obstet Gynecol Scand 2015; doi: 10.1111/aogs.12807.
46. Gordon R, Magee LA, Payne B et al. Magnesium sulphate for the management of preeclampsia and eclampsia in low and middle income countries: a systematic review of tested dosing regimens. J Obstet Gynaecol Can 2014; 36 (2): 154–63.
47. Okusanya BO, Oladapo OT, Long Q et al. Clinical pharmacokinetic properties of magnesium sulphate in women with pre-eclampsia and eclampsia: a systematic review. BJOG 2015.
48. Klinicheskie rekomendatsii (protokol lecheniia) «Organizatsiia meditsinskoi evakuatsii pri prezhdevremennykh rodakh». M., 2015. [in Russian]
49. Klinicheskie rekomendatsii (protokol lecheniia) «Prezhdevremennye rody». M., 2013. [in Russian]
50. Gromova O.A., Torshin I.Iu., Pronin A.V. i dr. Meta-analiz effektivnosti i bezopasnosti primeneniia organicheskikh solei magniia v akusherskoi praktike. Akush. i ginekol. 2014; 10: 33–40. [in Russian]
51. Rotter I, Kosik-Bogacka DI, Dolgowska B et al. Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging. Environ Geochem Health 2016; 38 (3): 749–61; doi: 10.1007/s10653-015-9758-0.
52. De Baaij JH, Hoenderop JG, Bindels RJ. Magnesium in man: implications for health and disease. Physiol Rev 2015; 95 (1): 1–46; doi: 10.1152/physrev.00012.2014.
53. Maggio M, de Vita F, Lauretani F et al. The Interplay between Magnesium and Testosterone in Modulating Physical Function in Men. Int J Endocrinol 2014; 2014: 525249; doi: 10.1155/2014/525249.
54. Liang H, Miao M, Chen J et al. The Association Between Calcium, Magnesium, and Ratio of Calcium/Magnesium in Seminal Plasma and Sperm Quality. Biol Trace Elem Res 2016.
Авторы
Н.В.Артымук*, О.А.Тачкова, В.О.Червов
ФГБОУ ВО Кемеровский государственный медицинский университет Минздрава России. 650029, Россия, Кемерово, ул. Ворошилова, д. 22а
*roddom_kokb@mail.ru
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N.V.Artymuk*, O.A.Tachkova, V.O.Chervov
Kemerovo State Medical University of the Ministry of Health of the Russian Federation. 650029, Russian Federation, Kemerovo, ul. Voroshilova, d. 22a
*roddom_kokb@mail.ru