Одним из проявлений гастроэзофагеальной рефлюксной болезни (ГЭРБ) являются экстрапищеводные симптомы, в частности со стороны верхних и нижних дыхательных путей. Гастроэзофагеальный рефлюкс способен как самостоятельно вызывать респираторные симптомы, так и усугублять течение уже имеющихся заболеваний органов дыхания. В статье представлены имеющиеся в литературе современные сведения о патогенезе респираторных симптомов ГЭРБ, их клинического течения, вопросы диагностики и лечения.
Одним из проявлений гастроэзофагеальной рефлюксной болезни (ГЭРБ) являются экстрапищеводные симптомы, в частности со стороны верхних и нижних дыхательных путей. Гастроэзофагеальный рефлюкс способен как самостоятельно вызывать респираторные симптомы, так и усугублять течение уже имеющихся заболеваний органов дыхания. В статье представлены имеющиеся в литературе современные сведения о патогенезе респираторных симптомов ГЭРБ, их клинического течения, вопросы диагностики и лечения.
1. Hunt R, Armstrong D, Katelaris P, et al. World Gastroenterology Organisation Global Guidelines. J Clin Gastroenterol. 2017;51(6):467-478. doi: 10.1097/mcg.0000000000000854
2. Pomari C, Mauroner L, Paiano S, Assante L, Bertolaccini L, Ruffo G, Mainardi P, Bocus P, Geccherle A, Albanese S, Ciaffoni S. Bronchial reacutization and gastroesophageal reflux: is there a potential clinical correlation? Ann Translat Med. 2016;4(16):304. doi: 10.21037/atm. 2016.08.40
3. Hogan W. Spectrum of Supraesophageal Complications of Gastroesophageal Reflux Disease. Am J Med. 1997;103(5):77S-83S.
doi: 10.1016/s0002-9343(97)00329-x
4. Toohill R, Kuhn J. Role of Refluxed Acid in Pathogenesis of Laryngeal Disorders. Am J Med. 1997;103(5):100S-106S. doi: 10.1016/s0002-9343(97)00333-1
5. Sidwa F, Moore A, Alligood E, Fisichella P. Surgical Treatment of Extraesophageal Manifestations of Gastroesophageal Reflux Disease. World J Surg. 2017;41(10):2566-2571. doi: 10.1007/s00268-017-4058-8
6. Solidoro P, Patrucco F, Fagoonee S, Pellicano R. Asthma and gastroesophageal reflux disease: a multidisciplinary point of view. Minerva Med. 2017;108(4):350-356. doi: 10.23736/S0026-4806.17.05181-3
7. Martinucci I, Albano E, Marchi S, Blandizzi C. Extra-esophageal presentation of gastroesophageal reflux disease: new understanding in a new era. Minerva Gastroenterol Dietol. 2017;63(3):221-234.
doi: 10.23736/S1121-421X.17.02393-5
8. Fisichella PM, Andolfi C, Orthopoulos G. Evaluation of Gastro-esophageal Reflux Disease. World J Surg. 2017;41(7):1672-1677.
doi: 10.1007/s00268-017-3953-3
9. Zerbib F, Dulery C. Facts and Fantasies on Extraesophageal Reflux. J Clin Gastroenterol. 2017;51(9):769-776. doi: 10.1097/mcg.0000000000000918
10. Locke G, Talley N, Fett S, Zinsmeister A, Melton L. Prevalence and clinical spectrum of gastroesophageal reflux: A population-based study in Olmsted County, Minnesota. Gastroenterology. 1997;112(5):1448-1456. doi: 10.1016/s0016-5085(97)70025-8
11. Koufman J. The Otolaryngologic Manifestations of Gastroesophageal Reflux Disease (GERD): A Clinical Investigation of 225 Patients Using Ambulatory 24-Hour pH Monitoring and an Experimental Investigation of the Role of Acid and Pepsin in the Development of Laryngeal. Laryngoscope. 1991;101:1-78. doi: 10.1002/lary.1991.101.s53.1
12. El-Serag H, Sonnenberg A. Comorbid occurrence of laryngeal or pulmonary disease with esophagitis in United States military veterans. Gastroenterology. 1997;113(3):755-760. doi: 10.1016/s0016-5085(97) 70168-9
13. Havemann B, Henderson C, El-Serag H. The association between gastro-oesophageal reflux disease and asthma: a systematic review. Gut. 2007;56(12):1654-1664. doi: 10.1136/gut.2007.122465
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16. Araujo A, Aprile L, Dantas R, Terra-Filho J, Vianna E. Bronchial Responsiveness During Esophageal Acid Infusion. Lung. 2008;186 (2):123-128. doi: 10.1007/s00408-008-9072-z
17. Daoui S, D’Agostino B, Gallelli L, Emonds Alt X, Rossi F, Advenier C. Tachykinins and airway microvascular leakage induced by HCl intra-oesophageal instillation. Eur Respir J. 2002;20(2):268-273.
doi: 10.1183/09031936.02.00250902
18. Patterson R, Johnston B, Ardill J, Heaney L, McGarvey L. Increased tachykinin levels in induced sputum from asthmatic and cough patients with acid reflux. Thorax. 2007;62(6):491-495. doi: 10.1136/thx. 2006.063982
19. Woodley F, Mousa H. Acid Gastroesophageal Reflux Reports in Infants: A Comparison of Esophageal pH Monitoring and Multichannel Intraluminal Impedance Measurements. Dig Dis Sci. 2006;51(11): 1910-1916. doi: 10.1007/s10620-006-9179-0
20. Михайлов А.Н., Римашевский В.Б. Гастроэзофагеальная рефлюксная болезнь. Медицинские новости. 2011;(8):6-10. [Mikhailov AN, Rimashevskii VB. Gastroesophageal reflux disease. Meditsinskie novosti. 2011;(8):6-10 (In Russ.)].
21. Hampel M, Abraham NS, El-Serag HB. Meta-analysis: obesity and the risk for gastro-oesophageal reflux disease and its complications. Ann Intern Med. 2005;143:199-211.
22. Ruigoґmez A, Rodriguez LA, Wallander MA, Johansson S, Thomas M, Price D. Gastro-oesophageal reflux disease and asthma: a longitudinal study in UK general practice. Chest. 2005;128:85-93. doi: 10.1378/ chest.128.1.85
23. Houghton L, Smith J. Gastro-oesophageal reflux events: just another trigger in chronic cough? Gut. 2017;66(12):2047-2048. doi: 10.1136/ gutjnl-2017-314027
24. Rogha M, Behravesh B, Pourmoghaddas Z. Association of gastroesophageal reflux disease symptoms with exacerbations of chronic obstructive pulmonary disease. J Gastrointest Liver Dis. 2010;19(3):253-256.
25. Bor S, Kitapcioglu G, Solak Z, Ertilav M, Erdinc M. Prevalence of gastroesophageal reflux disease in patients with asthma and chronic obstructive pulmonary disease. J Gastroenterol Hepatol. 2010;25(2): 309-313. doi: 10.1111/j.1440-1746.2009.06035.x
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27. Hekking PW, Amelink M, Wener RR, Bouvy ML, Bel EH. Comorbidities in Difficult-to-Control Asthma. J Allerg Clin Immunol. In Pract. 2017;19:30473-30477. doi: 10.1016/j.jaip.2017.06.008
28. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2017. http://ginasthma.org/2017-gina-report-global-strategy-for-asthma-management-and-prevention/
29. Петров Ю.В., Глотов С.И., Абросимов В.Н. Первый опыт применения интрапульмональной электронной аускультации у пациентов с хронической обструктивной болезнью легких и бронхиальной астмой. Наука молодых – Eruditio Juvenium. 2015;23(4):45-49 [Petrov YuV, Glotov SI, Abrosimov VN. First experience of intrapulmonary electronic auscultation in patients with COPD and bronchial asthma. Nauka Molodykh – Eruditio Juvenium. 2015;23(4):45-49 (In Russ.)].
30. Michaudet C, Malaty J. Chronic Cough: Evaluation and Management. Am Fam Phys. 2017;96(9):575-580.
31. Irwin RS, French CL, Chang AB, Altman KW; CHEST Expert Cough Panel. Classification of Cough As a Symptom in Adults and Management Algorithms: CHEST Guideline and Expert Panel Report. Chest. 2018 Jan;153(1):196-209. doi: 10.1016/j.chest.2017.10.016
32. Dettmar P, Strugala V, Fathi H, Dettmar H, Wright C, Morice A. The online Cough Clinic: developing guideline-based diagnosis and advice. Eur Respir J. 2009;34(4): 819-824. doi: 10.1183/09031936.00126908
33. Correction to reference in: Treatment of Unexplained Chronic Cough: CHEST Guideline and Expert Panel Report. Chest. 2016;149(5):1353. doi: 10.1016/j.chest.2016.03.014
34. Hsu W, Lai C, Wang Y, et al. Risk of pneumonia in patients with gastroesophageal reflux disease: A population-based cohort study. PLOS ONE. 2017;12(8):e0183808. doi: 10.1371/journal.pone.0183808
35. Zhang C, Hu Z, Yan C, et al. Nissen fundoplication vs proton pump inhibitors for laryngopharyngeal reflux based on pH-monitoring and symptom-scale. World J Gastroenterol. 2017;23(19):3546.
doi: 10.3748/wjg.v23.i19.3546
36. Vaezi M. Reflux-induced laryngitis (laryngopharyngeal reflux). Curr Treat Opt Gastroenterol. 2006;9(1):69-74. doi: 10.1007/s11938-006-0025-4
37. Poelmans J, Feenstra L, Demedts I, Rutgeerts P, Tack J. The Yield of Upper Gastrointestinal Endoscopy in Patients with Suspected Reflux-Related Chronic Ear, Nose, and Throat Symptoms. Am J Gastroenterol. 2004;99(8):1419-1426. doi: 10.1111/j.1572-0241.2004.30066.x
38. Poe RH, Kallay MC. Chronic cough and gastroesophageal reflux disease: experience with specific therapy for diagnosis and treatment. Chest. 2003;123:679-684.
39. Балабанцева А.П., Кляритская И.Л. Экстраэзофагеальные манифестации ГЭРБ. Крымский терапевтический журнал. 2010;(1):8-14 [Balabantseva AP, Klyaritskaya IL. Extra-esophageal manifestations of GERD. Krymskii Terapevticheskii Zhurnal. 2010;(1):8-14 (In Russ.)].
40. Delahunty J. Acid laryngitis. J Laryngol Otol. 1972;86(04):335-342. doi: 10.1017/s0022215100075356
41. Ylitalo R, Ramel S. Extraesophageal Reflux in Patients with Contact Granuloma: A Prospective Controlled Study. Ann Otol Rhinol Laryngol. 2002;111(5):441-446. doi: 10.1177/000348940211100509
42. Jindal J, Milbrath M, Hogan W, Shaker R, Toohill R. Gastroesophageal Reflux Disease as a Likely Cause of “Idiopathic” Subglottic Stenosis. Ann Otol Rhinol Laryngol. 1994;103(3):186-191. doi: 10.1177/ 000348949410300304
43. El-Serag H. Lansoprazole treatment of patients with chronic idiopathic laryngitis: a placebo-controlled trial. Am J Gastroenterol. 2001;96(4): 979-983. doi: 10.1016/s0002-9270(01)02244-4
44. Xu X, Chen Q, Liang S, Lü H, Qiu Z. Successful resolution of refractory chronic cough induced by gastroesophageal reflux with treatment of baclofen. Cough. 2012;8(1):8. doi: 10.1186/1745-9974-8-8
45. Kiljander T, Junghard O, Beckman O, Lind T. W1828 The Effect of Esomeprazole 40mg Once or Twice Daily On Asthma Outcome:
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________________________________________________
1. Hunt R, Armstrong D, Katelaris P, et al. World Gastroenterology Organisation Global Guidelines. J Clin Gastroenterol. 2017;51(6):467-478. doi: 10.1097/mcg.0000000000000854
2. Pomari C, Mauroner L, Paiano S, Assante L, Bertolaccini L, Ruffo G, Mainardi P, Bocus P, Geccherle A, Albanese S, Ciaffoni S. Bronchial reacutization and gastroesophageal reflux: is there a potential clinical correlation? Ann Translat Med. 2016;4(16):304. doi: 10.21037/atm. 2016.08.40
3. Hogan W. Spectrum of Supraesophageal Complications of Gastroesophageal Reflux Disease. Am J Med. 1997;103(5):77S-83S.
doi: 10.1016/s0002-9343(97)00329-x
4. Toohill R, Kuhn J. Role of Refluxed Acid in Pathogenesis of Laryngeal Disorders. Am J Med. 1997;103(5):100S-106S. doi: 10.1016/s0002-9343(97)00333-1
5. Sidwa F, Moore A, Alligood E, Fisichella P. Surgical Treatment of Extraesophageal Manifestations of Gastroesophageal Reflux Disease. World J Surg. 2017;41(10):2566-2571. doi: 10.1007/s00268-017-4058-8
6. Solidoro P, Patrucco F, Fagoonee S, Pellicano R. Asthma and gastroesophageal reflux disease: a multidisciplinary point of view. Minerva Med. 2017;108(4):350-356. doi: 10.23736/S0026-4806.17.05181-3
7. Martinucci I, Albano E, Marchi S, Blandizzi C. Extra-esophageal presentation of gastroesophageal reflux disease: new understanding in a new era. Minerva Gastroenterol Dietol. 2017;63(3):221-234.
doi: 10.23736/S1121-421X.17.02393-5
8. Fisichella PM, Andolfi C, Orthopoulos G. Evaluation of Gastro-esophageal Reflux Disease. World J Surg. 2017;41(7):1672-1677.
doi: 10.1007/s00268-017-3953-3
9. Zerbib F, Dulery C. Facts and Fantasies on Extraesophageal Reflux. J Clin Gastroenterol. 2017;51(9):769-776. doi: 10.1097/mcg.0000000000000918
10. Locke G, Talley N, Fett S, Zinsmeister A, Melton L. Prevalence and clinical spectrum of gastroesophageal reflux: A population-based study in Olmsted County, Minnesota. Gastroenterology. 1997;112(5):1448-1456. doi: 10.1016/s0016-5085(97)70025-8
11. Koufman J. The Otolaryngologic Manifestations of Gastroesophageal Reflux Disease (GERD): A Clinical Investigation of 225 Patients Using Ambulatory 24-Hour pH Monitoring and an Experimental Investigation of the Role of Acid and Pepsin in the Development of Laryngeal. Laryngoscope. 1991;101:1-78. doi: 10.1002/lary.1991.101.s53.1
12. El-Serag H, Sonnenberg A. Comorbid occurrence of laryngeal or pulmonary disease with esophagitis in United States military veterans. Gastroenterology. 1997;113(3):755-760. doi: 10.1016/s0016-5085(97) 70168-9
13. Havemann B, Henderson C, El-Serag H. The association between gastro-oesophageal reflux disease and asthma: a systematic review. Gut. 2007;56(12):1654-1664. doi: 10.1136/gut.2007.122465
14. [Il'yashevich IG, Konovalova NV, Tikhonov SV. Outboard displays of gastroesophageal reflux disease. Vestnik Severo-Zapadnogo Gosudarstvennogo Meditsinskogo Universiteta im. I.I. Mechnikova. 2013;5(1):93-100 (In Russ.)].
15. [Abdulmanapova DN, Chamsutdinov NU. Bronchopulmonary manifestations of gastroesophageal reflux disease: pathogenesis, clinicas and diagnostic. Sovremennye Problemy Nauki i Obrazovaniya. 2013;(2):1-7. (In Russ.)].
16. Araujo A, Aprile L, Dantas R, Terra-Filho J, Vianna E. Bronchial Responsiveness During Esophageal Acid Infusion. Lung. 2008;186 (2):123-128. doi: 10.1007/s00408-008-9072-z
17. Daoui S, D’Agostino B, Gallelli L, Emonds Alt X, Rossi F, Advenier C. Tachykinins and airway microvascular leakage induced by HCl intra-oesophageal instillation. Eur Respir J. 2002;20(2):268-273.
doi: 10.1183/09031936.02.00250902
18. Patterson R, Johnston B, Ardill J, Heaney L, McGarvey L. Increased tachykinin levels in induced sputum from asthmatic and cough patients with acid reflux. Thorax. 2007;62(6):491-495. doi: 10.1136/thx. 2006.063982
19. Woodley F, Mousa H. Acid Gastroesophageal Reflux Reports in Infants: A Comparison of Esophageal pH Monitoring and Multichannel Intraluminal Impedance Measurements. Dig Dis Sci. 2006;51(11): 1910-1916. doi: 10.1007/s10620-006-9179-0
20. [Mikhailov AN, Rimashevskii VB. Gastroesophageal reflux disease. Meditsinskie novosti. 2011;(8):6-10 (In Russ.)].
21. Hampel M, Abraham NS, El-Serag HB. Meta-analysis: obesity and the risk for gastro-oesophageal reflux disease and its complications. Ann Intern Med. 2005;143:199-211.
22. Ruigoґmez A, Rodriguez LA, Wallander MA, Johansson S, Thomas M, Price D. Gastro-oesophageal reflux disease and asthma: a longitudinal study in UK general practice. Chest. 2005;128:85-93. doi: 10.1378/ chest.128.1.85
23. Houghton L, Smith J. Gastro-oesophageal reflux events: just another trigger in chronic cough? Gut. 2017;66(12):2047-2048. doi: 10.1136/ gutjnl-2017-314027
24. Rogha M, Behravesh B, Pourmoghaddas Z. Association of gastroesophageal reflux disease symptoms with exacerbations of chronic obstructive pulmonary disease. J Gastrointest Liver Dis. 2010;19(3):253-256.
25. Bor S, Kitapcioglu G, Solak Z, Ertilav M, Erdinc M. Prevalence of gastroesophageal reflux disease in patients with asthma and chronic obstructive pulmonary disease. J Gastroenterol Hepatol. 2010;25(2): 309-313. doi: 10.1111/j.1440-1746.2009.06035.x
26. [Klyaritskaya IL, Balabantseva AP, Shkadova MG, Shakhbazidi G. The pathogenetic role and clinical significance of gastroesophageal reflux in bronchial asthma. Krymskii Terapevticheskii Zhurnal. 2013;(2):56-63 (In Russ.)].
27. Hekking PW, Amelink M, Wener RR, Bouvy ML, Bel EH. Comorbidities in Difficult-to-Control Asthma. J Allerg Clin Immunol. In Pract. 2017;19:30473-30477. doi: 10.1016/j.jaip.2017.06.008
28. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2017. http://ginasthma.org/2017-gina-report-global-strategy-for-asthma-management-and-prevention/
29. [Petrov YuV, Glotov SI, Abrosimov VN. First experience of intrapulmonary electronic auscultation in patients with COPD and bronchial asthma. Nauka Molodykh – Eruditio Juvenium. 2015;23(4):45-49 (In Russ.)].
30. Michaudet C, Malaty J. Chronic Cough: Evaluation and Management. Am Fam Phys. 2017;96(9):575-580.
31. Irwin RS, French CL, Chang AB, Altman KW; CHEST Expert Cough Panel. Classification of Cough As a Symptom in Adults and Management Algorithms: CHEST Guideline and Expert Panel Report. Chest. 2018 Jan;153(1):196-209. doi: 10.1016/j.chest.2017.10.016
32. Dettmar P, Strugala V, Fathi H, Dettmar H, Wright C, Morice A. The online Cough Clinic: developing guideline-based diagnosis and advice. Eur Respir J. 2009;34(4): 819-824. doi: 10.1183/09031936.00126908
33. Correction to reference in: Treatment of Unexplained Chronic Cough: CHEST Guideline and Expert Panel Report. Chest. 2016;149(5):1353. doi: 10.1016/j.chest.2016.03.014
34. Hsu W, Lai C, Wang Y, et al. Risk of pneumonia in patients with gastroesophageal reflux disease: A population-based cohort study. PLOS ONE. 2017;12(8):e0183808. doi: 10.1371/journal.pone.0183808
35. Zhang C, Hu Z, Yan C, et al. Nissen fundoplication vs proton pump inhibitors for laryngopharyngeal reflux based on pH-monitoring and symptom-scale. World J Gastroenterol. 2017;23(19):3546.
doi: 10.3748/wjg.v23.i19.3546
36. Vaezi M. Reflux-induced laryngitis (laryngopharyngeal reflux). Curr Treat Opt Gastroenterol. 2006;9(1):69-74. doi: 10.1007/s11938-006-0025-4
37. Poelmans J, Feenstra L, Demedts I, Rutgeerts P, Tack J. The Yield of Upper Gastrointestinal Endoscopy in Patients with Suspected Reflux-Related Chronic Ear, Nose, and Throat Symptoms. Am J Gastroenterol. 2004;99(8):1419-1426. doi: 10.1111/j.1572-0241.2004.30066.x
38. Poe RH, Kallay MC. Chronic cough and gastroesophageal reflux disease: experience with specific therapy for diagnosis and treatment. Chest. 2003;123:679-684.
39. [Balabantseva AP, Klyaritskaya IL. Extra-esophageal manifestations of GERD. Krymskii Terapevticheskii Zhurnal. 2010;(1):8-14 (In Russ.)].
40. Delahunty J. Acid laryngitis. J Laryngol Otol. 1972;86(04):335-342. doi: 10.1017/s0022215100075356
41. Ylitalo R, Ramel S. Extraesophageal Reflux in Patients with Contact Granuloma: A Prospective Controlled Study. Ann Otol Rhinol Laryngol. 2002;111(5):441-446. doi: 10.1177/000348940211100509
42. Jindal J, Milbrath M, Hogan W, Shaker R, Toohill R. Gastroesophageal Reflux Disease as a Likely Cause of “Idiopathic” Subglottic Stenosis. Ann Otol Rhinol Laryngol. 1994;103(3):186-191. doi: 10.1177/ 000348949410300304
43. El-Serag H. Lansoprazole treatment of patients with chronic idiopathic laryngitis: a placebo-controlled trial. Am J Gastroenterol. 2001;96(4): 979-983. doi: 10.1016/s0002-9270(01)02244-4
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