Пентоксифиллин и нефропротекция: влияние на почечную дисфункцию и кардиоваскулярные риски
Пентоксифиллин и нефропротекция: влияние на почечную дисфункцию и кардиоваскулярные риски
Муркамилов И.Т., Айтбаев К.А., Фомин В.В. и др. Пентоксифиллин и нефропротекция: влияние на почечную дисфункцию и кардиоваскулярные риски. Терапевтический архив. 2019; 91 (1): 16–100. DOI: 10.26442/00403660.2019.01.000037
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Murkamilov I.T., Aitbaev K.A., Fomin V.V. et al. Pentoxifylline and nephroprotection: effects on renal dysfunction and cardiovascular risks. Therapeutic Archive. 2019; 91 (1): 16–100.
DOI: 10.26442/00403660.2019.01.000037
Пентоксифиллин и нефропротекция: влияние на почечную дисфункцию и кардиоваскулярные риски
Муркамилов И.Т., Айтбаев К.А., Фомин В.В. и др. Пентоксифиллин и нефропротекция: влияние на почечную дисфункцию и кардиоваскулярные риски. Терапевтический архив. 2019; 91 (1): 16–100. DOI: 10.26442/00403660.2019.01.000037
________________________________________________
Murkamilov I.T., Aitbaev K.A., Fomin V.V. et al. Pentoxifylline and nephroprotection: effects on renal dysfunction and cardiovascular risks. Therapeutic Archive. 2019; 91 (1): 16–100.
DOI: 10.26442/00403660.2019.01.000037
Представлены обобщенные данные о нефропротективной эффективности пентоксифиллина при хронической болезни почек (ХБП). Рассматривается потенциал применения данного препарата у лиц, страдающих ХБП и сердечно-сосудистыми заболеваниями (ССЗ) с высоким риском развития терминальной стадии ренальной дисфункции. Антипротеинурический, антифибротический и противовоспалительный эффекты пентоксифиллина существенно снижают риск прогрессирования ХБП и присоединения ССЗ в будущем. Эффективность в предупреждении наступления уремической стадии ХБП, безопасность и возможность применения на всех этапах развития ренальной дисфункции делают пентоксифиллин весьма привлекательным препаратом не только для нефрологов, но и для терапевтов.
Generalized data on nephroprotective efficacy of pentoxifylline in chronic kidney disease (CKD) are presented. The potential of this drug in treating people suffering from CKD and cardiovascular diseases (CVD) with a high risk of developing the terminal stage of renal dysfunction is considered. Antiproteinuric, antifibrotic and anti-inflammatory effects of pentoxifylline significantly reduce the risk of progression of CKD and joining of CVD in the future. Efficacy in preventing the onset of the uremic stage of CKD, safety andapplicability at all stages of renal dysfunction development make pentoxifylline a very appealing drug not only for nephrologists but also for physicians.
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________________________________________________
1. Nephrology: guidelines for physicians]. Moscow: Meditsina; 2000; 688 p. (In Russ.)
2. Mukhin NА, editor. Nephrology: the national leadership. Moscow: GEOTAR-Media, 2009; 720 p. (Series National guidelines) (In Russ.)
3. Mandal AK. Pathogenesis and Prevention of Progression of Chronic Kidney Disease. Open J Internal Medicine. 2015;5:58-73. doi:10.4236/ojim. 20 15.53010
4. Liu ZZ, Bullen A, Li Y, Singh P. Renal Oxygenation in the Pathophysiology of Chronic Kidney Disease. Frontiers in physiology. 2017;8:385. doi:https://doi. org/10.3389/fphys.2017.00385
5. Babickova J, Klinkhammer BM, Buhl EM, et al. Regardless of etiology, progressive renal disease causes ultrastructural and functional alterations of peritubular capillaries. Kidney Int. 2017;91:70-85. doi:10.1016/j.kint.2016.07.038
6. Koshkin VM. Angiospasm and antispasmodic therapy for diseases of the arteries of the extremities. Surgery. 1979;9:71-5 (In Russ.)
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8. Solerte SB, Adamo S, Viola C, et al. Pentoxifylline and arterial hypertension in diabetes mellitus: long-term results in randomized groups. Ric Clin Lab. 1985;15(Suppl 1):515-26.
9. Strukov MA, Reznikov KM, Vasilenko IV, Firsova LI. Pharmacokinetics of pentoxifylline and its active metabolite in patients with traumatic brain injury. Applied informational aspects of medicine. 2015;4(18):15-21. (In Russ.)
10. Marsella R, Nicklin CF, Munson JW, Roberts SM. Pharmacokinetics of pentoxifylline in dogs after oral and intravenous administration. Am J Veterinary Res. 2000;6(61):631-7. https://doi.org/10.2460/ajvr.2000.61.631
11. Fischmeister R, Castro LR, Abi-Gerges A, et al. Compartmentation of cyclic nucleotide signaling in the heart: therole of cyclic nucleotide phosphodiesterases. Circ Res. 2006;99(8): 816-28.
12. Reneerkens OA, Rutten K, Steinbusch HW, et al. Selective phosphodiesterase inhibitors: a promising target for cognition enhancement. Psychopharmacology (Berl). 2009;202(1-3):419-43.
13. Fawcett L, Baxendale R, Stacey P, et al. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. Proc Natl Acad Sci USA. 2000;97:3702-7.
14. Ward A, Clissold SP. Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs. 1987;34(1):50-97.
15. Drozdov SA.Pentoxifylline in the treatment of disorders of cerebral circulation: an overview. Zhurnal nevrologii i psikhiatrii im. SS Korsakova.1997;(9):62-7 (In Russ.)
16. Hartmann A, Rommel T, Dettmers C, et al. Hemodilution in cerebral infarcts. Arzneimittelforschung. 1991;41:348-51.
17. Fomin VV. Common atherosclerosis in general therapeutic practice: on the way to optimizing tactics. Farmateka. 2010;18-19:27-31 (In Russ.)
18. Korkushko OV, Zharinova VYu, Bodretskaya LA, et al. The effect of pentoxifylline on the indices of hemovascular homeostasis, central hemodynamics, the level of inflammatory markers and the severity of apoptosis in elderly patients with coronary artery disease. Blood circulation and hemostasis. 2013;3-4:22-7 (In Russ.)
19. Fernandes J, de Oliveira R, Mamoni R. Pentoxifylline reduces pro-inflammatory and increases anti-inflammatory activity in patients with coronary artery disease – a randomized placebo-controlled study. Atherosclerosis. 2008;196(1):434-42.
20. Heinze HA, Rosemann C, Weber C. Single prophylactic dose of pentoxifyllinereduces high dependency unit time in cardiac surgery – a prospective randomized and controlled study. Eur J Cardiothorac Surg. 2007;32(1):83-9.
21. Shirokov EA. Pentoxifylline Second Coming to Preventive Cardioneurology. Russian Medical Journal. 2013;21(30):1556-1558 (In Russ.)
22. Kavata A, Aykut K, Sisli E, et al. Pentoxifylline inhibit intimal hyperplasia and vascular smooth muscle cell proliferation in a rabbit carotid artery anastomosis model. Afr J Pharm and Pharmocol. 2013;5:1-3.
23. Prasad K, Lee P. Suppression of hypercholesterolemic atherosclerosis by pentoxifylline and its mechanism. Atherosclerosis. 2007;192(2):313-22.
24. Angelides NS, Minas C. Can aortocoronary and peripheral venous bypass graft patency be improved by the administration of pentoxifylline on a long term basis? Cardiologia.1999;44(12):1059-64.
25. Moiseev VS, Mukhin NA, Smirnov AV, et al. National guidelines. Cardiovascular risk and chronic kidney disease: strategy of cardio-renoprotection. Klinicheskaya Farmacologiya i Terapiya = Clinical Pharmacology and Therapy. 2014;23(3):4-27 (In Russ.)
26. Atabek ME, Çağan HH, Eklioğlu BS, Oran B. Absence of increase in carotid artery intima-media thickness in infants of diabetic mothers. J Clinical Research in Pediatric Endocrinology. 2011;3(3):144. doi:10.4274/jcrpe.v3i3.28
27. Mohammadpour AH, Falsoleiman H, Shamsara J, Allah-Abadi G, et al. Ramezani M. Pentoxifylline decrease serum level of adhesion molecules in atherosclerosis patients. Iran Biomed J. 2014;18(1):23-7.
28. Mehanna OM, El Askary A, Al-Shehri S, El-EsawyB. Effect of phosphodiesterase inhibitors on renal functions and oxidant/antioxidant parameters in streptozocin-induced diabetic rats. Arch Physiol Biochem. 2017;22:1-6. doi:10.1080/13813455.2017.1419267
29. Siraeva TA, Kalmetyeva LR, Kamilov FKh, Enikeeva ZM. The relationship of urinary excretion of monocytic chemoattractant protein 1 and collagen metabolism in children with the hematuric form of chronic glomerulonephritis. Medicine: today's challenges: materials of the Intern. scientific conf. (Chelyabinsk, June 2012). Chelyabinsk: Two Komsomol members, 2012:79-81 (In Russ.) URL https://moluch.ru/conf/med/ archive/52/2493/
30. Tchebotareva NV, Bobkova IN, Kozlovskaja LV. Molecular mechanisms of interstitial fibrosis in the progression of renal diseases (Review). Nephrology and dialysis. 2006;1(8):26-35 (In Russ.)
31. Wada T, Yokoyama H, Su S, et al. Monitoring urinary levels of Monocyte chemotactic and activating factor reflects disease activity of lupus nephritis. Kidney Int. 1996;49:761-7.
32. Lin SL, Chen YM, Chiang WC, Wu KD, et al. Effect of pentoxifylline in addition to losartan on proteinuria and GFR in CKD: a 12-month randomized trial. Am J Kidney Dis. 2008;52(3):464-74. doi:10.1053/j.ajkd.2008.05.012
33. Shushlyapin ОI, Tuchinskaya MA, Kononenko LG, Saprichva LV. Key role of pentoxyfylline and enalapril in adjusting of proinflammatory effects of cytokines in cardiac insufficiency with metabolic syndrome. Scientific statements. Medicine series. Pharmacy. 2010;22(93):117-21 (In Russ.)
34. Marques LJ, Zheng L, Poulakis N, et al. Pentoxifylline inhibits TNF-α production from human alveolar macrophages. Am J respiratory and critical care medicine. 1999;159(2):508-11. doi: https://doi.org/10.1164/ ajrccm.159.2.9804085
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1 Кыргызская государственная медицинская академия им. И.К. Ахунбаева, Бишкек, Кыргызстан;
2 Кыргызско-Российский Славянский университет им. первого Президента России Б.Н. Ельцина, Бишкек, Кыргызстан;
3 Научно-исследовательский институт молекулярной биологии и медицины, Бишкек, Кыргызстан;
4 ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
5 Центр семейной медицины №7, Бишкек, Кыргызстан;
6 Национальный госпиталь при Министерстве здравоохранения Кыргызской Республики, Бишкек, Кыргызстан
1 Kyrgyz State Medical Academy named after I.K. Akhunbaev, Bishkek, Kyrgyzstan;
2 Kyrgyz Russian Slavic University named after the First President of Russia B.N. Yeltsin, Bishkek, Kyrgyzstan;
3 Scientific Research Institute of Molecular Biology and Medicine, Bishkek, Kyrgyzstan;
4 I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia;
5 Family Medicine Center №7, Bishkek, Kyrgyzstan;
6 National Hospital under the Ministry of Health of the Kyrgyz Republic, Bishkek, Kyrgyzstan