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Салусин-α и -β в качестве новых биологических маркёров при сердечно-сосудистых заболеваниях: обзор литературы
Салусин-α и -β в качестве новых биологических маркёров при сердечно-сосудистых заболеваниях: обзор литературы
Алиева А.М., Резник Е.В., Теплова Н.В., Гызыева М.Х., Рахаев А.М., Котикова И.А., Никитин И.Г. Салусин-α и -β в качестве новых биологических маркёров при сердечно-сосудистых заболеваниях: обзор литературы // CardioСоматика. 2023. Т 14, № 4. С. 257–268. DOI: https://doi.org/10.17816/CS568593
DOI: https://doi.org/10.17816/CS568593
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DOI: https://doi.org/10.17816/CS568593
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Аннотация
Несмотря на значительные достижения медицины, сердечно-сосудистые заболевания продолжают оставаться ведущей причиной смертности во всём мире. Важной задачей кардиологии являются поиск и изучение новых сердечно-сосудистых биологических маркёров. В последние годы интерес учёных привлекают салусины. Салусины являются эндогенными биологически активными пептидами, которые впервые были идентифицированы в 2003 году. Проведённые к настоящему времени исследования продемонстрировали, что салусин-α и -β играют важную роль в ремоделировании сосудов, при воспалении, артериальной гипертензии и атеросклеротических процессах. Салусин-α проявляет антиатерогенное действие, тогда как салусин-β играет проатерогенную роль. Несмотря на разнообразные биологические, физиологические и патофизиологические аспекты салуcинов, точный механизм их сердечно-сосудистых эффектов до конца не известен. Необходимы дальнейшие глубинные исследования роли салусинов при сердечно-сосудистых заболеваниях. Регуляция концентрации и экспрессии салусина-α и -β, возможно, окажется многообещающей стратегией для лечения больных кардиологического профиля.
Ключевые слова: cердечно-сосудистые заболевания, атеросклероз, ишемическая болезнь сердца, артериальная гипертензия, биологические маркёры, салусин-α,
салусин-β
Keywords: cardiovascular diseases, atherosclerosis, ischemic heart disease, arterial hypertension, biological markers, salusin-α, salusin-β
Ключевые слова: cердечно-сосудистые заболевания, атеросклероз, ишемическая болезнь сердца, артериальная гипертензия, биологические маркёры, салусин-α,
салусин-β
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Keywords: cardiovascular diseases, atherosclerosis, ischemic heart disease, arterial hypertension, biological markers, salusin-α, salusin-β
Полный текст
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Авторы
А.М. Алиева*1, Е.В. Резник1, Н.В. Теплова1, М.Х. Гызыева2, А.М. Рахаев3, И.А. Котикова1, И.Г. Никитин1
1Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, Москва, Россия;
2Пятигорский медико-фармацевтический институт, Пятигорск, Россия;
3Главное бюро медико-социальной экспертизы, Нальчик, Россия
*amisha_alieva@mail.ru
1Pirogov Russian National Research Medical University, Moscow, Russia;
2Pyatigorsk Medical and Pharmaceutical Institute, Pyatigorsk, Russia;
3Main Bureau of Medical and Social Expertise, Nalchik, Russia
*amisha_alieva@mail.ru
1Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, Москва, Россия;
2Пятигорский медико-фармацевтический институт, Пятигорск, Россия;
3Главное бюро медико-социальной экспертизы, Нальчик, Россия
*amisha_alieva@mail.ru
________________________________________________
1Pirogov Russian National Research Medical University, Moscow, Russia;
2Pyatigorsk Medical and Pharmaceutical Institute, Pyatigorsk, Russia;
3Main Bureau of Medical and Social Expertise, Nalchik, Russia
*amisha_alieva@mail.ru
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