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Ключевые изменения клинических рекомендаций по ведению пациентов с хронической сердечной недостаточностью
Ключевые изменения клинических рекомендаций по ведению пациентов с хронической сердечной недостаточностью
Ларина В.Н., Скиба И.К., Щербина Е.С., Лукин А.А. Ключевые изменения клинических рекомендаций по ведению пациентов с хронической сердечной недостаточностью // CardioСоматика. 2025. Т. 16, № 3. С. 240–249. DOI: 10.17816/CS643236 EDN: RSHICA
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Аннотация
Хроническая сердечная недостаточность (ХСН) становится всё более актуальной проблемой в контексте глобального старения населения и определённых достижений системы здравоохранения. В статье анализируются ключевые изменения клинических рекомендаций Европейского общества кардиологов и Российского кардиологического общества по ведению пациентов с ХСН, включая обновлённую классификацию и терапевтические подходы. Поиск литературных источников проведён в электронных базах данных Pubmed, Google Scholar, eLibrary.ru. Новая классификация направлена на улучшение профилактики ХСН, а не только на корректный выбор тактики терапии существующего заболевания. Обсуждается роль ингибиторов натрий-глюкозного котранспортёра 2-го типа, ангиотензиновых рецепторов и неприлизина ингибиторов, а также освещается место нового антагониста минералкортикоидных рецепторов — финеренона. Обобщение последних исследований и экспертного опыта обеспечивает специалистов современными знаниями о лечении ХСН. Однако наиболее важный аспект обновлённых рекомендаций — превентивный подход, направленный на предотвращение развития ХСН. Актуальные данные могут быть полезны как для врачей первичного звена, так и для врачей, оказывающих медицинскую помощь в условиях стационара, врачей-исследователей и позволят повысить качество и улучшить результаты лечения пациентов.
Ключевые слова: хроническая сердечная недостаточность, классификация, финеренон, квадротерапия, клинические рекомендации
Keywords: heart failure, classification, finerenone, quadruple therapy, clinical guidelines
Ключевые слова: хроническая сердечная недостаточность, классификация, финеренон, квадротерапия, клинические рекомендации
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Keywords: heart failure, classification, finerenone, quadruple therapy, clinical guidelines
Полный текст
Список литературы
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17. Anker SD, Butler J, Filippatos G, et al; EMPEROR-Preserved Trial Investigators. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med. 2021;385(16):1451–1461. doi: 10.1056/NEJMoa2107038
18. Solomon SD, McMurray JJV, Claggett B, et al. DELIVER Trial Committees and Investigators. Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction. N Engl J Med. 2022;387(12):1089–1098. doi: 10.1056/NEJMoa2206286
19. Savarese G, Stolfo D, Sinagra G, Lund LH. Heart failure with mid-range or mildly reduced ejection fraction. Nat Rev Cardiol. 2022;19(2):100–116. doi: 10.1038/s41569-021-00605-5 EDN: VDJCBV
20. Xia H, Shen H, Cha W, Lu Q. The prognostic significance of anemia in patients with heart failure: A meta-analysis of studies from the last decade. Front Cardiovasc Med. 2021;8:632318. doi: 10.3389/fcvm.2021.632318 EDN: LIFTFR
21. Kalra PR, Cleland JGF, Petrie MC, et al. IRONMAN Study Group. Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): An investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial. Lancet. 2022;400:2199–2209. doi: 10.1016/s0140-6736(22)02083-9 EDN: LDHVYG
22. Bakris GL, Agarwal R, Anker SD, et al. Effect of finerenone on chronic kidney disease outcomes in type 2 diabetes. N Engl J Med. 2020;383:2219–2229. doi: 10.1056/NEJMoa2025845 EDN: PJUWTM
23. Pitt B, Filippatos G, Agarwal R, et al. Cardiovascular events with finerenone in kidney disease and type 2 diabetes. N Engl J Med. 2021;385:2252–2263. doi: 10.1056/NEJMoa2110956 EDN: ISNXNF
24. Agarwal R, Joseph A, Anker SD, et al. FIDELIO-DKD Investigators. Hyperkalemia Risk with Finerenone: Results from the FIDELIO-DKD Trial. J Am Soc Nephrol. 2022;33(1):225–237. doi: 10.1681/ASN.2021070942 EDN: MRBFCI
25. Vardeny O, Vaduganathan M, Claggett BL, et al. Finerenone, Serum Potassium, and Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction. JAMA Cardiol. 2025;10(1):42–48. doi: 10.1001/jamacardio.2024.4539
26. Kokorin VA, Gonzalez-Franco A, Cittadini A, et al. Acute heart failure — an EFIM guideline critical appraisal and adaptation for internists. Eur J Int Med. 2024;123:4–14. doi: 10.1016/j.ejim.2024.02.028
27. Bozkurt B, Coats AJS, Tsutsui H, et al. Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure: Endorsed by the Canadian Heart Failure Society, Heart Failure Association of India, Cardiac Society of Australia and New Zealand, and Chinese Heart Failure Association. Eur J Heart Fail. 2021;23(3):352–380. doi: 10.1002/ejhf.2115 EDN: TQXZTY
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29. Chronic heart failure. Clinical guidelines 2024. Russ J Cardiol. 2024;29(11). doi: 10.15829/1560-4071-2024-6162
30. Galyavich AS, Nedogoda SV, Arutyunov GP, et al. About the classification of heart failure. Russ J Cardiol. 2023;28(9):5584. doi: 10.15829/1560-4071- 2023-5584 EDN: ZGXELX
31. Fedin MA, Izumov AD, Eruslanova KA, et al. Domain management as the best way of manage patient with heart failure and geriatrics syndromes. Russ J Geriatric Medicine. 2020;(4):313–326. doi: 10.37586/2686-8636-4-2020-313-326
32. Fedin MA, Vorobyeva NM, Izyumov AD, et al. Peculiarities of geriatric status in patients with chronic heart failure over the age of 65: data from the EUCALYPTUS study. Arterialnaya Gipertenziya (Arterial Hypertension). 2023;29(3):286–298. doi: 10.18705/1607-419X-2023-29-3-286-298
33. Izyumov AD, Eruslanova KA, Mkhitaryan EA, et al. Relationship between cognitive status and other geriatric syndromes in patients aged 65 years and older with chronic heart failure. Adv Gerontol. 2024;37(3):287–294. doi: 10.34922/AE.2024.37.3.015 EDN: PUOIYE
34. Leening MJ, Elias-Smale SE, Kavousi M, et al. Coronary calcification and the risk of heart failure in the elderly: the Rotterdam Study. JACC Cardiovasc Imaging. 2012;5:874–880. doi: 10.1016/j.jcmg.2012.03.016
35. Effoe VS, McClendon EE, Rodriguez CJ, et al. Diabetes status modifies the association between carotid intima-media thickness and incident heart failure: the Atherosclerosis Risk in Communities study. Diabetes Res Clin Pract. 2017;128:58–66. doi: 10.1016/j.diabres.2017.04.009
36. Lopatin YM, Nedogoda SV, Arkhipov MV, et al. Pharmacoepidemiological analysis of routine management of heart failure patients in the Russian Federation. Part I. Russ J Cardiol. 2021;26(4):4368. doi: 10.15829/1560-4071-2021-4368 EDN: XKYUXP
37. Chernyavskaya TK, Glezer MG. Clinical characteristics and treatment of outpatients with chronic heart failure in the Moscow Region. Almanac of Clinical Medicine. 2021;49(2):125–131. doi: 10.18786/2072-0505-2021-49-023 EDN: RLRUIG
38. Crespo-Leiro MG, Anker SD, Maggioni AP, et al. Heart Failure Association (HFA) of the European Society of Cardiology (ESC). European Society of Cardiology Heart Failure Long-Term Registry (ESC-HF-LT): 1-year follow-up outcomes and differences across regions. Eur J Heart Fail. 2016;18(6):613–625. doi: 10.1002/ejhf.566
39. Lam CS, Solomon SD. The middle child in heart failure: heart failure with mid-range ejection fraction (40–50%). Eur J Heart Fail. 2014;16(10):1049–1055. doi: 10.1002/ejhf.159 EDN: UQKAPD
2. Nair A, Tuan LQ, Jones-Lewis N, et al. Heart Failure with Mildly Reduced Ejection Fraction-A Phenotype Waiting to Be Explored. J Cardiovasc Dev Dis. 2024;11(5):148. doi: 10.3390/jcdd11050148 EDN: KZTBPC
3. Savarese G, Becher PM, Lund LH, et al. Global burden of heart failure: a comprehensive and updated review of epidemiology. Cardiovasc Res. 2023;118(17):3272–3287. doi: 10.1093/cvr/cvac013 EDN: RAACZU
4. Reitblat OM, Airapetian AA, Lazareva NV, et al. Creation of registers as one of the mechanisms for improving medical care for patients with chronic heart failure. Problem State. Ter Arkh. 2023;95(9):739–745. doi: 10.26442/00403660.2023.09.202370 EDN: HBMDDP
5. Groenewegen A, Rutten FH, Mosterd A, Hoes AW. Epidemiology of heart failure. Eur J Heart Fail. 2020;22(8):1342–1356. doi: 10.1002/ejhf.1858
6. Ang N, Chandramouli C, Yiu K, et al. Heart Failure and Multimorbidity in Asia. Curr Heart Fail Rep. 2023;20(1):24–32. doi: 10.1007/s11897-023-00585-2 EDN: EZTIQT
7. Siqueira S, Pabon M, Ostrominski J, et al. Prognostic impact of hepatorenal dysfunction and cardiovascular-kidneymetabolic multimorbidity in heart failure: a participant-level pooled analysis of the paradigm-hf and paragon‑hf trials. JACC. 2025;85(12_Suppl):1339. doi: 10.1016/S0735-1097(25)01823-6
8. Beezer J, Al Hatrushi M, Husband A, et al. Polypharmacy definition and prevalence in heart failure: a systematic review. Heart Fail Rev. 2022;27(2):465–492. doi: 10.1007/s10741-021-10135-4 EDN: PHSHUJ
9. Unlu O, Levitan EB, Reshetnyak E, et al. Polypharmacy in Older Adults Hospitalized for Heart Failure. Circ Heart Fail. 2020;13(11):e006977. doi: 10.1161/CIRCHEARTFAILURE.120.006977 EDN: VGBHLG
10. Palazzuoli A, Ruocco G, Gronda E. Noncardiac comorbidity clustering in heart failure: an overlooked aspect with potential therapeutic door. Heart Fail Rev. 2022;27(3):767–778. doi: 10.1007/s10741-020-09972-6 EDN: SGQKID
11. Hollenberg SM, Warner Stevenson L, Ahmad T, et al. 2019 ACC Expert Consensus Decision Pathway on Risk Assessment, Management, and Clinical Trajectory of Patients Hospitalized with Heart Failure: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll 12. Cardiol. 2019;74(15):1966–2011. doi: 10.1016/j.jacc.2019.08.001 EDN: ELMOPY
Savarese G, Lund LH. Global Public Health Burden of Heart Failure. Card Fail Rev. 2017;3(1):7–11. doi: 10.15420/cfr.2016:25:2 EDN: RAACZU
13. Polyakov DS, Fomin IV, Belenkov YuN, et al. Chronic heart failure in the Russian Federation: what has changed over 20 years of follow‑up? Results of the EPOCH-CHF study. Kardiologiia. 2021;61(4):4–14. doi: 10.18087/cardio.2021.4.n1628 EDN: WSZNFS
14. Norhammar A, Bodegard J, Vanderheyden M, et al. Prevalence, outcomes and costs of a contemporary, multinational population with heart failure. Heart. 2023;109(7):548–556. doi: 10.1136/heartjnl-2022-321702
15. Packer M, Anker SD, Butler J, et al; EMPEROR-Reduced Trial Investigators. Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure. N Engl J Med. 2020;383(15):1413–1424. doi: 10.1056/NEJMoa2022190
16. Zinman B, Wanner C, Lachin J, et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med. 2015;373:2117–2128. doi: 10.1056/NEJMoa1504720 EDN: VBZQID
17. Anker SD, Butler J, Filippatos G, et al; EMPEROR-Preserved Trial Investigators. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med. 2021;385(16):1451–1461. doi: 10.1056/NEJMoa2107038
18. Solomon SD, McMurray JJV, Claggett B, et al. DELIVER Trial Committees and Investigators. Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction. N Engl J Med. 2022;387(12):1089–1098. doi: 10.1056/NEJMoa2206286
19. Savarese G, Stolfo D, Sinagra G, Lund LH. Heart failure with mid-range or mildly reduced ejection fraction. Nat Rev Cardiol. 2022;19(2):100–116. doi: 10.1038/s41569-021-00605-5 EDN: VDJCBV
20. Xia H, Shen H, Cha W, Lu Q. The prognostic significance of anemia in patients with heart failure: A meta-analysis of studies from the last decade. Front Cardiovasc Med. 2021;8:632318. doi: 10.3389/fcvm.2021.632318 EDN: LIFTFR
21. Kalra PR, Cleland JGF, Petrie MC, et al. IRONMAN Study Group. Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): An investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial. Lancet. 2022;400:2199–2209. doi: 10.1016/s0140-6736(22)02083-9 EDN: LDHVYG
22. Bakris GL, Agarwal R, Anker SD, et al. Effect of finerenone on chronic kidney disease outcomes in type 2 diabetes. N Engl J Med. 2020;383:2219–2229. doi: 10.1056/NEJMoa2025845 EDN: PJUWTM
23. Pitt B, Filippatos G, Agarwal R, et al. Cardiovascular events with finerenone in kidney disease and type 2 diabetes. N Engl J Med. 2021;385:2252–2263. doi: 10.1056/NEJMoa2110956 EDN: ISNXNF
24. Agarwal R, Joseph A, Anker SD, et al. FIDELIO-DKD Investigators. Hyperkalemia Risk with Finerenone: Results from the FIDELIO-DKD Trial. J Am Soc Nephrol. 2022;33(1):225–237. doi: 10.1681/ASN.2021070942 EDN: MRBFCI
25. Vardeny O, Vaduganathan M, Claggett BL, et al. Finerenone, Serum Potassium, and Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction. JAMA Cardiol. 2025;10(1):42–48. doi: 10.1001/jamacardio.2024.4539
26. Kokorin VA, Gonzalez-Franco A, Cittadini A, et al. Acute heart failure — an EFIM guideline critical appraisal and adaptation for internists. Eur J Int Med. 2024;123:4–14. doi: 10.1016/j.ejim.2024.02.028
27. Bozkurt B, Coats AJS, Tsutsui H, et al. Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure: Endorsed by the Canadian Heart Failure Society, Heart Failure Association of India, Cardiac Society of Australia and New Zealand, and Chinese Heart Failure Association. Eur J Heart Fail. 2021;23(3):352–380. doi: 10.1002/ejhf.2115 EDN: TQXZTY
28. Acute coronary syndrome without ST-segment elevation electrocardiogram. Clinical guidelines 2024. Russ J Cardiol. 2025;30(5):6319. doi: 10.15829/1560-4071-2025-6319
29. Chronic heart failure. Clinical guidelines 2024. Russ J Cardiol. 2024;29(11). doi: 10.15829/1560-4071-2024-6162
30. Galyavich AS, Nedogoda SV, Arutyunov GP, et al. About the classification of heart failure. Russ J Cardiol. 2023;28(9):5584. doi: 10.15829/1560-4071- 2023-5584 EDN: ZGXELX
31. Fedin MA, Izumov AD, Eruslanova KA, et al. Domain management as the best way of manage patient with heart failure and geriatrics syndromes. Russ J Geriatric Medicine. 2020;(4):313–326. doi: 10.37586/2686-8636-4-2020-313-326
32. Fedin MA, Vorobyeva NM, Izyumov AD, et al. Peculiarities of geriatric status in patients with chronic heart failure over the age of 65: data from the EUCALYPTUS study. Arterialnaya Gipertenziya (Arterial Hypertension). 2023;29(3):286–298. doi: 10.18705/1607-419X-2023-29-3-286-298
33. Izyumov AD, Eruslanova KA, Mkhitaryan EA, et al. Relationship between cognitive status and other geriatric syndromes in patients aged 65 years and older with chronic heart failure. Adv Gerontol. 2024;37(3):287–294. doi: 10.34922/AE.2024.37.3.015 EDN: PUOIYE
34. Leening MJ, Elias-Smale SE, Kavousi M, et al. Coronary calcification and the risk of heart failure in the elderly: the Rotterdam Study. JACC Cardiovasc Imaging. 2012;5:874–880. doi: 10.1016/j.jcmg.2012.03.016
35. Effoe VS, McClendon EE, Rodriguez CJ, et al. Diabetes status modifies the association between carotid intima-media thickness and incident heart failure: the Atherosclerosis Risk in Communities study. Diabetes Res Clin Pract. 2017;128:58–66. doi: 10.1016/j.diabres.2017.04.009
36. Lopatin YM, Nedogoda SV, Arkhipov MV, et al. Pharmacoepidemiological analysis of routine management of heart failure patients in the Russian Federation. Part I. Russ J Cardiol. 2021;26(4):4368. doi: 10.15829/1560-4071-2021-4368 EDN: XKYUXP
37. Chernyavskaya TK, Glezer MG. Clinical characteristics and treatment of outpatients with chronic heart failure in the Moscow Region. Almanac of Clinical Medicine. 2021;49(2):125–131. doi: 10.18786/2072-0505-2021-49-023 EDN: RLRUIG
38. Crespo-Leiro MG, Anker SD, Maggioni AP, et al. Heart Failure Association (HFA) of the European Society of Cardiology (ESC). European Society of Cardiology Heart Failure Long-Term Registry (ESC-HF-LT): 1-year follow-up outcomes and differences across regions. Eur J Heart Fail. 2016;18(6):613–625. doi: 10.1002/ejhf.566
39. Lam CS, Solomon SD. The middle child in heart failure: heart failure with mid-range ejection fraction (40–50%). Eur J Heart Fail. 2014;16(10):1049–1055. doi: 10.1002/ejhf.159 EDN: UQKAPD
2. Nair A, Tuan LQ, Jones-Lewis N, et al. Heart Failure with Mildly Reduced Ejection Fraction-A Phenotype Waiting to Be Explored. J Cardiovasc Dev Dis. 2024;11(5):148. doi: 10.3390/jcdd11050148 EDN: KZTBPC
3. Savarese G, Becher PM, Lund LH, et al. Global burden of heart failure: a comprehensive and updated review of epidemiology. Cardiovasc Res. 2023;118(17):3272–3287. doi: 10.1093/cvr/cvac013 EDN: RAACZU
4. Reitblat OM, Airapetian AA, Lazareva NV, et al. Creation of registers as one of the mechanisms for improving medical care for patients with chronic heart failure. Problem State. Ter Arkh. 2023;95(9):739–745. doi: 10.26442/00403660.2023.09.202370 EDN: HBMDDP
5. Groenewegen A, Rutten FH, Mosterd A, Hoes AW. Epidemiology of heart failure. Eur J Heart Fail. 2020;22(8):1342–1356. doi: 10.1002/ejhf.1858
6. Ang N, Chandramouli C, Yiu K, et al. Heart Failure and Multimorbidity in Asia. Curr Heart Fail Rep. 2023;20(1):24–32. doi: 10.1007/s11897-023-00585-2 EDN: EZTIQT
7. Siqueira S, Pabon M, Ostrominski J, et al. Prognostic impact of hepatorenal dysfunction and cardiovascular-kidneymetabolic multimorbidity in heart failure: a participant-level pooled analysis of the paradigm-hf and paragon‑hf trials. JACC. 2025;85(12_Suppl):1339. doi: 10.1016/S0735-1097(25)01823-6
8. Beezer J, Al Hatrushi M, Husband A, et al. Polypharmacy definition and prevalence in heart failure: a systematic review. Heart Fail Rev. 2022;27(2):465–492. doi: 10.1007/s10741-021-10135-4 EDN: PHSHUJ
9. Unlu O, Levitan EB, Reshetnyak E, et al. Polypharmacy in Older Adults Hospitalized for Heart Failure. Circ Heart Fail. 2020;13(11):e006977. doi: 10.1161/CIRCHEARTFAILURE.120.006977 EDN: VGBHLG
10. Palazzuoli A, Ruocco G, Gronda E. Noncardiac comorbidity clustering in heart failure: an overlooked aspect with potential therapeutic door. Heart Fail Rev. 2022;27(3):767–778. doi: 10.1007/s10741-020-09972-6 EDN: SGQKID
11. Hollenberg SM, Warner Stevenson L, Ahmad T, et al. 2019 ACC Expert Consensus Decision Pathway on Risk Assessment, Management, and Clinical Trajectory of Patients Hospitalized with Heart Failure: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll 12. Cardiol. 2019;74(15):1966–2011. doi: 10.1016/j.jacc.2019.08.001 EDN: ELMOPY
Savarese G, Lund LH. Global Public Health Burden of Heart Failure. Card Fail Rev. 2017;3(1):7–11. doi: 10.15420/cfr.2016:25:2 EDN: RAACZU
13. Polyakov DS, Fomin IV, Belenkov YuN, et al. Chronic heart failure in the Russian Federation: what has changed over 20 years of follow‑up? Results of the EPOCH-CHF study. Kardiologiia. 2021;61(4):4–14. doi: 10.18087/cardio.2021.4.n1628 EDN: WSZNFS
14. Norhammar A, Bodegard J, Vanderheyden M, et al. Prevalence, outcomes and costs of a contemporary, multinational population with heart failure. Heart. 2023;109(7):548–556. doi: 10.1136/heartjnl-2022-321702
15. Packer M, Anker SD, Butler J, et al; EMPEROR-Reduced Trial Investigators. Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure. N Engl J Med. 2020;383(15):1413–1424. doi: 10.1056/NEJMoa2022190
16. Zinman B, Wanner C, Lachin J, et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med. 2015;373:2117–2128. doi: 10.1056/NEJMoa1504720 EDN: VBZQID
17. Anker SD, Butler J, Filippatos G, et al; EMPEROR-Preserved Trial Investigators. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med. 2021;385(16):1451–1461. doi: 10.1056/NEJMoa2107038
18. Solomon SD, McMurray JJV, Claggett B, et al. DELIVER Trial Committees and Investigators. Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction. N Engl J Med. 2022;387(12):1089–1098. doi: 10.1056/NEJMoa2206286
19. Savarese G, Stolfo D, Sinagra G, Lund LH. Heart failure with mid-range or mildly reduced ejection fraction. Nat Rev Cardiol. 2022;19(2):100–116. doi: 10.1038/s41569-021-00605-5 EDN: VDJCBV
20. Xia H, Shen H, Cha W, Lu Q. The prognostic significance of anemia in patients with heart failure: A meta-analysis of studies from the last decade. Front Cardiovasc Med. 2021;8:632318. doi: 10.3389/fcvm.2021.632318 EDN: LIFTFR
21. Kalra PR, Cleland JGF, Petrie MC, et al. IRONMAN Study Group. Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): An investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial. Lancet. 2022;400:2199–2209. doi: 10.1016/s0140-6736(22)02083-9 EDN: LDHVYG
22. Bakris GL, Agarwal R, Anker SD, et al. Effect of finerenone on chronic kidney disease outcomes in type 2 diabetes. N Engl J Med. 2020;383:2219–2229. doi: 10.1056/NEJMoa2025845 EDN: PJUWTM
23. Pitt B, Filippatos G, Agarwal R, et al. Cardiovascular events with finerenone in kidney disease and type 2 diabetes. N Engl J Med. 2021;385:2252–2263. doi: 10.1056/NEJMoa2110956 EDN: ISNXNF
24. Agarwal R, Joseph A, Anker SD, et al. FIDELIO-DKD Investigators. Hyperkalemia Risk with Finerenone: Results from the FIDELIO-DKD Trial. J Am Soc Nephrol. 2022;33(1):225–237. doi: 10.1681/ASN.2021070942 EDN: MRBFCI
25. Vardeny O, Vaduganathan M, Claggett BL, et al. Finerenone, Serum Potassium, and Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction. JAMA Cardiol. 2025;10(1):42–48. doi: 10.1001/jamacardio.2024.4539
26. Kokorin VA, Gonzalez-Franco A, Cittadini A, et al. Acute heart failure — an EFIM guideline critical appraisal and adaptation for internists. Eur J Int Med. 2024;123:4–14. doi: 10.1016/j.ejim.2024.02.028
27. Bozkurt B, Coats AJS, Tsutsui H, et al. Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure: Endorsed by the Canadian Heart Failure Society, Heart Failure Association of India, Cardiac Society of Australia and New Zealand, and Chinese Heart Failure Association. Eur J Heart Fail. 2021;23(3):352–380. doi: 10.1002/ejhf.2115 EDN: TQXZTY
28. Acute coronary syndrome without ST-segment elevation electrocardiogram. Clinical guidelines 2024. Russ J Cardiol. 2025;30(5):6319. doi: 10.15829/1560-4071-2025-6319
29. Chronic heart failure. Clinical guidelines 2024. Russ J Cardiol. 2024;29(11). doi: 10.15829/1560-4071-2024-6162
30. Galyavich AS, Nedogoda SV, Arutyunov GP, et al. About the classification of heart failure. Russ J Cardiol. 2023;28(9):5584. doi: 10.15829/1560-4071- 2023-5584 EDN: ZGXELX
31. Fedin MA, Izumov AD, Eruslanova KA, et al. Domain management as the best way of manage patient with heart failure and geriatrics syndromes. Russ J Geriatric Medicine. 2020;(4):313–326. doi: 10.37586/2686-8636-4-2020-313-326
32. Fedin MA, Vorobyeva NM, Izyumov AD, et al. Peculiarities of geriatric status in patients with chronic heart failure over the age of 65: data from the EUCALYPTUS study. Arterialnaya Gipertenziya (Arterial Hypertension). 2023;29(3):286–298. doi: 10.18705/1607-419X-2023-29-3-286-298
33. Izyumov AD, Eruslanova KA, Mkhitaryan EA, et al. Relationship between cognitive status and other geriatric syndromes in patients aged 65 years and older with chronic heart failure. Adv Gerontol. 2024;37(3):287–294. doi: 10.34922/AE.2024.37.3.015 EDN: PUOIYE
34. Leening MJ, Elias-Smale SE, Kavousi M, et al. Coronary calcification and the risk of heart failure in the elderly: the Rotterdam Study. JACC Cardiovasc Imaging. 2012;5:874–880. doi: 10.1016/j.jcmg.2012.03.016
35. Effoe VS, McClendon EE, Rodriguez CJ, et al. Diabetes status modifies the association between carotid intima-media thickness and incident heart failure: the Atherosclerosis Risk in Communities study. Diabetes Res Clin Pract. 2017;128:58–66. doi: 10.1016/j.diabres.2017.04.009
36. Lopatin YM, Nedogoda SV, Arkhipov MV, et al. Pharmacoepidemiological analysis of routine management of heart failure patients in the Russian Federation. Part I. Russ J Cardiol. 2021;26(4):4368. doi: 10.15829/1560-4071-2021-4368 EDN: XKYUXP
37. Chernyavskaya TK, Glezer MG. Clinical characteristics and treatment of outpatients with chronic heart failure in the Moscow Region. Almanac of Clinical Medicine. 2021;49(2):125–131. doi: 10.18786/2072-0505-2021-49-023 EDN: RLRUIG
38. Crespo-Leiro MG, Anker SD, Maggioni AP, et al. Heart Failure Association (HFA) of the European Society of Cardiology (ESC). European Society of Cardiology Heart Failure Long-Term Registry (ESC-HF-LT): 1-year follow-up outcomes and differences across regions. Eur J Heart Fail. 2016;18(6):613–625. doi: 10.1002/ejhf.566
39. Lam CS, Solomon SD. The middle child in heart failure: heart failure with mid-range ejection fraction (40–50%). Eur J Heart Fail. 2014;16(10):1049–1055. doi: 10.1002/ejhf.159 EDN: UQKAPD
________________________________________________
2. Nair A, Tuan LQ, Jones-Lewis N, et al. Heart Failure with Mildly Reduced Ejection Fraction-A Phenotype Waiting to Be Explored. J Cardiovasc Dev Dis. 2024;11(5):148. doi: 10.3390/jcdd11050148 EDN: KZTBPC
3. Savarese G, Becher PM, Lund LH, et al. Global burden of heart failure: a comprehensive and updated review of epidemiology. Cardiovasc Res. 2023;118(17):3272–3287. doi: 10.1093/cvr/cvac013 EDN: RAACZU
4. Reitblat OM, Airapetian AA, Lazareva NV, et al. Creation of registers as one of the mechanisms for improving medical care for patients with chronic heart failure. Problem State. Ter Arkh. 2023;95(9):739–745. doi: 10.26442/00403660.2023.09.202370 EDN: HBMDDP
5. Groenewegen A, Rutten FH, Mosterd A, Hoes AW. Epidemiology of heart failure. Eur J Heart Fail. 2020;22(8):1342–1356. doi: 10.1002/ejhf.1858
6. Ang N, Chandramouli C, Yiu K, et al. Heart Failure and Multimorbidity in Asia. Curr Heart Fail Rep. 2023;20(1):24–32. doi: 10.1007/s11897-023-00585-2 EDN: EZTIQT
7. Siqueira S, Pabon M, Ostrominski J, et al. Prognostic impact of hepatorenal dysfunction and cardiovascular-kidneymetabolic multimorbidity in heart failure: a participant-level pooled analysis of the paradigm-hf and paragon‑hf trials. JACC. 2025;85(12_Suppl):1339. doi: 10.1016/S0735-1097(25)01823-6
8. Beezer J, Al Hatrushi M, Husband A, et al. Polypharmacy definition and prevalence in heart failure: a systematic review. Heart Fail Rev. 2022;27(2):465–492. doi: 10.1007/s10741-021-10135-4 EDN: PHSHUJ
9. Unlu O, Levitan EB, Reshetnyak E, et al. Polypharmacy in Older Adults Hospitalized for Heart Failure. Circ Heart Fail. 2020;13(11):e006977. doi: 10.1161/CIRCHEARTFAILURE.120.006977 EDN: VGBHLG
10. Palazzuoli A, Ruocco G, Gronda E. Noncardiac comorbidity clustering in heart failure: an overlooked aspect with potential therapeutic door. Heart Fail Rev. 2022;27(3):767–778. doi: 10.1007/s10741-020-09972-6 EDN: SGQKID
11. Hollenberg SM, Warner Stevenson L, Ahmad T, et al. 2019 ACC Expert Consensus Decision Pathway on Risk Assessment, Management, and Clinical Trajectory of Patients Hospitalized with Heart Failure: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll 12. Cardiol. 2019;74(15):1966–2011. doi: 10.1016/j.jacc.2019.08.001 EDN: ELMOPY
Savarese G, Lund LH. Global Public Health Burden of Heart Failure. Card Fail Rev. 2017;3(1):7–11. doi: 10.15420/cfr.2016:25:2 EDN: RAACZU
13. Polyakov DS, Fomin IV, Belenkov YuN, et al. Chronic heart failure in the Russian Federation: what has changed over 20 years of follow‑up? Results of the EPOCH-CHF study. Kardiologiia. 2021;61(4):4–14. doi: 10.18087/cardio.2021.4.n1628 EDN: WSZNFS
14. Norhammar A, Bodegard J, Vanderheyden M, et al. Prevalence, outcomes and costs of a contemporary, multinational population with heart failure. Heart. 2023;109(7):548–556. doi: 10.1136/heartjnl-2022-321702
15. Packer M, Anker SD, Butler J, et al; EMPEROR-Reduced Trial Investigators. Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure. N Engl J Med. 2020;383(15):1413–1424. doi: 10.1056/NEJMoa2022190
16. Zinman B, Wanner C, Lachin J, et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med. 2015;373:2117–2128. doi: 10.1056/NEJMoa1504720 EDN: VBZQID
17. Anker SD, Butler J, Filippatos G, et al; EMPEROR-Preserved Trial Investigators. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med. 2021;385(16):1451–1461. doi: 10.1056/NEJMoa2107038
18. Solomon SD, McMurray JJV, Claggett B, et al. DELIVER Trial Committees and Investigators. Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction. N Engl J Med. 2022;387(12):1089–1098. doi: 10.1056/NEJMoa2206286
19. Savarese G, Stolfo D, Sinagra G, Lund LH. Heart failure with mid-range or mildly reduced ejection fraction. Nat Rev Cardiol. 2022;19(2):100–116. doi: 10.1038/s41569-021-00605-5 EDN: VDJCBV
20. Xia H, Shen H, Cha W, Lu Q. The prognostic significance of anemia in patients with heart failure: A meta-analysis of studies from the last decade. Front Cardiovasc Med. 2021;8:632318. doi: 10.3389/fcvm.2021.632318 EDN: LIFTFR
21. Kalra PR, Cleland JGF, Petrie MC, et al. IRONMAN Study Group. Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): An investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial. Lancet. 2022;400:2199–2209. doi: 10.1016/s0140-6736(22)02083-9 EDN: LDHVYG
22. Bakris GL, Agarwal R, Anker SD, et al. Effect of finerenone on chronic kidney disease outcomes in type 2 diabetes. N Engl J Med. 2020;383:2219–2229. doi: 10.1056/NEJMoa2025845 EDN: PJUWTM
23. Pitt B, Filippatos G, Agarwal R, et al. Cardiovascular events with finerenone in kidney disease and type 2 diabetes. N Engl J Med. 2021;385:2252–2263. doi: 10.1056/NEJMoa2110956 EDN: ISNXNF
24. Agarwal R, Joseph A, Anker SD, et al. FIDELIO-DKD Investigators. Hyperkalemia Risk with Finerenone: Results from the FIDELIO-DKD Trial. J Am Soc Nephrol. 2022;33(1):225–237. doi: 10.1681/ASN.2021070942 EDN: MRBFCI
25. Vardeny O, Vaduganathan M, Claggett BL, et al. Finerenone, Serum Potassium, and Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction. JAMA Cardiol. 2025;10(1):42–48. doi: 10.1001/jamacardio.2024.4539
26. Kokorin VA, Gonzalez-Franco A, Cittadini A, et al. Acute heart failure — an EFIM guideline critical appraisal and adaptation for internists. Eur J Int Med. 2024;123:4–14. doi: 10.1016/j.ejim.2024.02.028
27. Bozkurt B, Coats AJS, Tsutsui H, et al. Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure: Endorsed by the Canadian Heart Failure Society, Heart Failure Association of India, Cardiac Society of Australia and New Zealand, and Chinese Heart Failure Association. Eur J Heart Fail. 2021;23(3):352–380. doi: 10.1002/ejhf.2115 EDN: TQXZTY
28. Acute coronary syndrome without ST-segment elevation electrocardiogram. Clinical guidelines 2024. Russ J Cardiol. 2025;30(5):6319. doi: 10.15829/1560-4071-2025-6319
29. Chronic heart failure. Clinical guidelines 2024. Russ J Cardiol. 2024;29(11). doi: 10.15829/1560-4071-2024-6162
30. Galyavich AS, Nedogoda SV, Arutyunov GP, et al. About the classification of heart failure. Russ J Cardiol. 2023;28(9):5584. doi: 10.15829/1560-4071- 2023-5584 EDN: ZGXELX
31. Fedin MA, Izumov AD, Eruslanova KA, et al. Domain management as the best way of manage patient with heart failure and geriatrics syndromes. Russ J Geriatric Medicine. 2020;(4):313–326. doi: 10.37586/2686-8636-4-2020-313-326
32. Fedin MA, Vorobyeva NM, Izyumov AD, et al. Peculiarities of geriatric status in patients with chronic heart failure over the age of 65: data from the EUCALYPTUS study. Arterialnaya Gipertenziya (Arterial Hypertension). 2023;29(3):286–298. doi: 10.18705/1607-419X-2023-29-3-286-298
33. Izyumov AD, Eruslanova KA, Mkhitaryan EA, et al. Relationship between cognitive status and other geriatric syndromes in patients aged 65 years and older with chronic heart failure. Adv Gerontol. 2024;37(3):287–294. doi: 10.34922/AE.2024.37.3.015 EDN: PUOIYE
34. Leening MJ, Elias-Smale SE, Kavousi M, et al. Coronary calcification and the risk of heart failure in the elderly: the Rotterdam Study. JACC Cardiovasc Imaging. 2012;5:874–880. doi: 10.1016/j.jcmg.2012.03.016
35. Effoe VS, McClendon EE, Rodriguez CJ, et al. Diabetes status modifies the association between carotid intima-media thickness and incident heart failure: the Atherosclerosis Risk in Communities study. Diabetes Res Clin Pract. 2017;128:58–66. doi: 10.1016/j.diabres.2017.04.009
36. Lopatin YM, Nedogoda SV, Arkhipov MV, et al. Pharmacoepidemiological analysis of routine management of heart failure patients in the Russian Federation. Part I. Russ J Cardiol. 2021;26(4):4368. doi: 10.15829/1560-4071-2021-4368 EDN: XKYUXP
37. Chernyavskaya TK, Glezer MG. Clinical characteristics and treatment of outpatients with chronic heart failure in the Moscow Region. Almanac of Clinical Medicine. 2021;49(2):125–131. doi: 10.18786/2072-0505-2021-49-023 EDN: RLRUIG
38. Crespo-Leiro MG, Anker SD, Maggioni AP, et al. Heart Failure Association (HFA) of the European Society of Cardiology (ESC). European Society of Cardiology Heart Failure Long-Term Registry (ESC-HF-LT): 1-year follow-up outcomes and differences across regions. Eur J Heart Fail. 2016;18(6):613–625. doi: 10.1002/ejhf.566
39. Lam CS, Solomon SD. The middle child in heart failure: heart failure with mid-range ejection fraction (40–50%). Eur J Heart Fail. 2014;16(10):1049–1055. doi: 10.1002/ejhf.159 EDN: UQKAPD
Авторы
В.Н. Ларина*1, И.К. Скиба1, Е.С. Щербина1, А.А. Лукин2
1Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, Москва, Россия;
2Диагностический клинический центр № 1, Москва, Россия
*larinav@mail.ru
1The Russian National Research Medical University named after N.I. Pirogov, Moscow, Russia;
2Diagnostic Clinical Center No. 1, Moscow, Russia
*larinav@mail.ru
1Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, Москва, Россия;
2Диагностический клинический центр № 1, Москва, Россия
*larinav@mail.ru
________________________________________________
1The Russian National Research Medical University named after N.I. Pirogov, Moscow, Russia;
2Diagnostic Clinical Center No. 1, Moscow, Russia
*larinav@mail.ru
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