Материалы доступны только для специалистов сферы здравоохранения.
Чтобы посмотреть материал полностью
Авторизуйтесь
или зарегистрируйтесь.
Влияние интервальных гипокси-гипероксических тренировок на переносимость физической нагрузки, когнитивные функции и артериальную жёсткость сосудов у пожилых пациентов с инфарктом миокарда и хронической сердечной недостаточностью
Влияние интервальных гипокси-гипероксических тренировок на переносимость физической нагрузки, когнитивные функции и артериальную жёсткость сосудов у пожилых пациентов с инфарктом миокарда и хронической сердечной недостаточностью
Андреева А.В., Андреева Ю.А., Якушин С.С., Лямина Н.П. Влияние интервальных гипокси-гипероксических тренировок на переносимость физической нагрузки, когнитивные функции и артериальную жёсткость сосудов у пожилых пациентов с инфарктом миокарда и хронической сердечной недостаточностью // CardioСоматика. 2025. Т. 16, № 4. С. 298–307. DOI: 10.17816/CS691745 EDN: HERPXH
________________________________________________
Материалы доступны только для специалистов сферы здравоохранения.
Чтобы посмотреть материал полностью
Авторизуйтесь
или зарегистрируйтесь.
Аннотация
Обоснование. Несмотря на успехи в лечении инфаркта миокарда, он остаётся одной из основных причин развития сердечной недостаточности. Кардиологическая реабилитация нацелена на минимизацию времени восстановления физической, социальной и психологической работоспособности после сердечного события. Одним из перспективных методов реабилитации пациентов, перенёсших инфаркт миокарда, является применение интервальных гипоксигипероксических тренировок (ИГГТ).
Цель — оценка влияния применения ИГГТ в дополнение к стандартной программе реабилитации на толерантность к физической нагрузке, концентрацию NT-proBNP, показатели жёсткости сосудистой стенки артерий и когнитивные функции пациентов пожилого возраста с инфарктом миокарда на 2-м стационарном этапе и хронической сердечной недостаточностью
Методы. Проведено одноцентровое проспективное рандомизированное контролируемое простое слепое исследование в параллельных группах. В исследование включено 102 пациента, рандомизированных на две группы: основная группа (n=51) получала стандартную реабилитацию в сочетании с ИГГТ на аппарате ReOxy; группа контроля (n=51) получала только стандартную реабилитацию. Курс ИГГТ состоял из 10 ежедневных сеансов (5 сеансов в неделю в течение 2 недель) продолжительностью 40 минут каждый. Первичной конечной точкой было изменение дистанции в тесте шестиминутной ходьбы, вторичными конечными точками — изменение концентрации NT-proBNP, когнитивных функций по Монреальской шкале оценки когнитивных функций (MoCA) и жёсткости артерий, оцениваемой по сердечно-лодыжечному сосудистому индексу (CAVI) с помощью системы VaSera VS-1500N. Статистический анализ проводился с использованием программы GraphPad Prism 8.
Результаты. Группы были сопоставимы по клиническим и демографическим характеристикам на момент начала исследования (p >0,05). Добавление ИГГТ к программе реабилитации привело к достоверно большему приросту дистанции в тесте шестиминутной ходьбы по сравнению с группой только стандартной реабилитации (51,0 [33,0; 86,0] м против 30,0 [22,5; 56,0] м, p=0,0001), а также большей степени снижения NT-proBNP (250,7 [115,7; 564,1] против 192,9 [109,45; 290,5], p=0,0243). В группе ИГГТ также наблюдалось более выраженное улучшение показателей когнитивных функций по шкале MoCA (3,0 [2,0; 4,5] балла против 2,0 [1,0; 3,0] балла, p=0,0005). В группе ИГГТ отмечена тенденция снижения правого сердечно-лодыжечного сосудистого индекса (R-CAVI) по сравнению с контрольной группой (Δ –0,5 [0,0; 1,1] против Δ –0,2 [0,0; 0,7], p=0,05). Достоверных межгрупповых различий в показателях левого CAVI (L-CAVI) и лодыжечно-плечевого индекса не выявлено.
Заключение. Добавление ИГГТ к стандартной программе реабилитации пациентов с инфарктом миокарда и сердечной недостаточностью улучшает переносимость физических нагрузок и когнитивные функции.
Ключевые слова: инфаркт миокарда, хроническая сердечная недостаточность, интервальные гипокси-гипероксические тренировки, кардиореабилитация, тест шестиминутной ходьбы, когнитивные функции, жёсткость артерий, сердечно-лодыжечный сосудистый индекс
AIM: To evaluate the effect of IHHT, added to a standard rehabilitation program, on exercise tolerance, NT-proBNP levels, arterial stiffness parameters, and cognitive function in older patients with myocardial infarction at the second inpatient stage of rehabilitation and chronic heart failure.
METHODS: A single-center, prospective, randomized, controlled, single-blind study with parallel groups was conducted. A total of 102 patients were enrolled and randomized into two groups: the main group (n = 51) received standard rehabilitation combined with IHHT using the ReOxy device, whereas the control group (n = 51) received standard rehabilitation only. The IHHT course consisted of 10 daily sessions (5 sessions per week for 2 weeks), each lasting 40 minutes. The primary endpoint was the change in six-minute walk test distance. Secondary endpoints included changes in NT-proBNP concentration, cognitive function assessed using the Montreal Cognitive Assessment (MoCA), and arterial stiffness evaluated by the cardio-ankle vascular index (CAVI) using the VaSera VS-1500N system. Statistical analysis was performed using GraphPad Prism 8.
RESULTS: The groups were comparable in baseline clinical and demographic characteristics (p > 0.05). The addition of IHHT to the rehabilitation program resulted in a significantly greater increase in six-minute walk distance compared with standard rehabilitation alone (51.0 [33.0; 86.0] m vs 30.0 [22.5; 56.0] m, p = 0.0001), as well as a greater reduction in NT-proBNP levels (250.7 [115.7; 564.1] vs 192.9 [109.45; 290.5], p = 0.0243). The IHHT group also demonstrated a more pronounced improvement in cognitive function according to the MoCA score (3.0 [2.0; 4.5] points vs 2.0 [1.0; 3.0] points, p = 0.0005). A trend toward a greater reduction in the right cardio-ankle vascular index (R-CAVI) was observed in the IHHT group compared with controls (Δ −0.5 [0.0; 1.1] vs Δ −0.2 [0.0; 0.7], p = 0.05). No significant between-group differences were found for left CAVI (L-CAVI) or ankle–brachial index.
CONCLUSION: The addition of IHHT to standard rehabilitation in patients with myocardial infarction and chronic heart failure improves exercise tolerance and cognitive function.
Keywords: myocardial infarction, chronic heart failure, intermittent hypoxic–hyperoxic training, cardiac rehabilitation, six‑minute walk test, cognitive function, arterial stiffness, cardio-ankle vascular index
Цель — оценка влияния применения ИГГТ в дополнение к стандартной программе реабилитации на толерантность к физической нагрузке, концентрацию NT-proBNP, показатели жёсткости сосудистой стенки артерий и когнитивные функции пациентов пожилого возраста с инфарктом миокарда на 2-м стационарном этапе и хронической сердечной недостаточностью
Методы. Проведено одноцентровое проспективное рандомизированное контролируемое простое слепое исследование в параллельных группах. В исследование включено 102 пациента, рандомизированных на две группы: основная группа (n=51) получала стандартную реабилитацию в сочетании с ИГГТ на аппарате ReOxy; группа контроля (n=51) получала только стандартную реабилитацию. Курс ИГГТ состоял из 10 ежедневных сеансов (5 сеансов в неделю в течение 2 недель) продолжительностью 40 минут каждый. Первичной конечной точкой было изменение дистанции в тесте шестиминутной ходьбы, вторичными конечными точками — изменение концентрации NT-proBNP, когнитивных функций по Монреальской шкале оценки когнитивных функций (MoCA) и жёсткости артерий, оцениваемой по сердечно-лодыжечному сосудистому индексу (CAVI) с помощью системы VaSera VS-1500N. Статистический анализ проводился с использованием программы GraphPad Prism 8.
Результаты. Группы были сопоставимы по клиническим и демографическим характеристикам на момент начала исследования (p >0,05). Добавление ИГГТ к программе реабилитации привело к достоверно большему приросту дистанции в тесте шестиминутной ходьбы по сравнению с группой только стандартной реабилитации (51,0 [33,0; 86,0] м против 30,0 [22,5; 56,0] м, p=0,0001), а также большей степени снижения NT-proBNP (250,7 [115,7; 564,1] против 192,9 [109,45; 290,5], p=0,0243). В группе ИГГТ также наблюдалось более выраженное улучшение показателей когнитивных функций по шкале MoCA (3,0 [2,0; 4,5] балла против 2,0 [1,0; 3,0] балла, p=0,0005). В группе ИГГТ отмечена тенденция снижения правого сердечно-лодыжечного сосудистого индекса (R-CAVI) по сравнению с контрольной группой (Δ –0,5 [0,0; 1,1] против Δ –0,2 [0,0; 0,7], p=0,05). Достоверных межгрупповых различий в показателях левого CAVI (L-CAVI) и лодыжечно-плечевого индекса не выявлено.
Заключение. Добавление ИГГТ к стандартной программе реабилитации пациентов с инфарктом миокарда и сердечной недостаточностью улучшает переносимость физических нагрузок и когнитивные функции.
Ключевые слова: инфаркт миокарда, хроническая сердечная недостаточность, интервальные гипокси-гипероксические тренировки, кардиореабилитация, тест шестиминутной ходьбы, когнитивные функции, жёсткость артерий, сердечно-лодыжечный сосудистый индекс
________________________________________________
AIM: To evaluate the effect of IHHT, added to a standard rehabilitation program, on exercise tolerance, NT-proBNP levels, arterial stiffness parameters, and cognitive function in older patients with myocardial infarction at the second inpatient stage of rehabilitation and chronic heart failure.
METHODS: A single-center, prospective, randomized, controlled, single-blind study with parallel groups was conducted. A total of 102 patients were enrolled and randomized into two groups: the main group (n = 51) received standard rehabilitation combined with IHHT using the ReOxy device, whereas the control group (n = 51) received standard rehabilitation only. The IHHT course consisted of 10 daily sessions (5 sessions per week for 2 weeks), each lasting 40 minutes. The primary endpoint was the change in six-minute walk test distance. Secondary endpoints included changes in NT-proBNP concentration, cognitive function assessed using the Montreal Cognitive Assessment (MoCA), and arterial stiffness evaluated by the cardio-ankle vascular index (CAVI) using the VaSera VS-1500N system. Statistical analysis was performed using GraphPad Prism 8.
RESULTS: The groups were comparable in baseline clinical and demographic characteristics (p > 0.05). The addition of IHHT to the rehabilitation program resulted in a significantly greater increase in six-minute walk distance compared with standard rehabilitation alone (51.0 [33.0; 86.0] m vs 30.0 [22.5; 56.0] m, p = 0.0001), as well as a greater reduction in NT-proBNP levels (250.7 [115.7; 564.1] vs 192.9 [109.45; 290.5], p = 0.0243). The IHHT group also demonstrated a more pronounced improvement in cognitive function according to the MoCA score (3.0 [2.0; 4.5] points vs 2.0 [1.0; 3.0] points, p = 0.0005). A trend toward a greater reduction in the right cardio-ankle vascular index (R-CAVI) was observed in the IHHT group compared with controls (Δ −0.5 [0.0; 1.1] vs Δ −0.2 [0.0; 0.7], p = 0.05). No significant between-group differences were found for left CAVI (L-CAVI) or ankle–brachial index.
CONCLUSION: The addition of IHHT to standard rehabilitation in patients with myocardial infarction and chronic heart failure improves exercise tolerance and cognitive function.
Keywords: myocardial infarction, chronic heart failure, intermittent hypoxic–hyperoxic training, cardiac rehabilitation, six‑minute walk test, cognitive function, arterial stiffness, cardio-ankle vascular index
Полный текст
Список литературы
1. Valaker I, Norekvål TM, Råholm MB, et al. Continuity of care after percutaneous coronary intervention: The patient's perspective across secondary and primary care settings. Eur J Cardiovasc Nurs. 2017;16(5):444–452. doi: 10.1177/1474515116687719 EDN: YHHMDX
2. Zhao E, Lowres N, Woolaston A, et al. Prevalence and patterns of cognitive impairment in acute coronary syndrome patients: A systematic review. Eur J Prev Cardiol. 2020;27(3):284–293. doi: 10.1177/2047487319878945 EDN: XOUQPO
3. Petrova MM, Leiman AR, Ustyugov SA, Schneider NA, Petrov AV. Vascular cognitive impairment in patients after acute myocardial infarction. Russian Journal of Cardiology. 2025;30(6S):6087. doi: 10.15829/1560-4071-2025-6087 EDN: MPFWGC
4. Yuan SM, Lin H. Postoperative Cognitive Dysfunction after Coronary Artery Bypass Grafting. Brazilian Journal of Cardiovascular Surgery. 2019;34(1):76–84. doi: 10.21470/1678-9741-2018-0165 EDN: OGBQMG
5. Gu SZ, Beska B, Chan D, et al. Cognitive Decline in Older Patients with Non-ST Elevation Acute Coronary Syndrome. J Am Heart Assoc. 2019;8(15):e011218. doi: 10.1161/JAHA.118.011218
6. Weber B, Bersch-Ferreira ÂC, Torreglosa CR, et al. Implementation of a Brazilian Cardioprotective Nutritional (BALANCE) Program for improvement on quality of diet and secondary prevention of cardiovascular events: A randomized, multicenter trial. Am Heart J. 2019;215:187–197. doi: 10.1016/j.ahj.2019.06.007 EDN: VKLTKO
7. Grässler B, Thielmann B, Böckelmann I, Hökelmann A. Effects of different exercise interventions on cardiac autonomic control and secondary health factors in middle-aged adults: A Systematic Review. J Cardiovasc Dev Dis. 2021;8(8):94. doi: 10.3390/jcdd8080094 EDN: XXCPMI
8. Mansilla-Chacón M, Gómez-Urquiza JL, Martos-Cabrera MB, et al. Effects of Supervised Cardiac Rehabilitation Programmes on Quality of Life among Myocardial Infarction Patients: A Systematic Review and Meta‑Analysis. J Cardiovasc Dev Dis. 2021;8(12):166. doi: 10.3390/jcdd8120166 EDN: IIODSM
9. Uryasiev OM, Isaeva IA. Intravenous lasertherapy and interval normobaric hypoxytherapy effectiveness in asthma and comorbid essential hypertension complex therapy. Zemskii vrach. 2014;(3-4(24)):25–28. EDN: TAWVTD
10. Isaeva IA, Uryasiev OM, Chuntyzheva EG, Pristupa AS. Effectiveness of application of complexes of physical factors in patients with bronchial asthma and comorbid essential hypertension. Nauka molodykh (Eruditio Juvenium). 2018;(1). doi: 10.23888/HMJ2018163-73 EDN: YVKBSU
11. Neubauer JA. Invited review: Physiological and pathophysiological responses to intermittent hypoxia. J Appl Physiol (1985). 2001;90(4):1593–1599. doi: 10.1152/jappl.2001.90.4.1593 EDN: XORQYZ
12. Conway EM, Collen D, Carmeliet P. Molecular mechanisms of blood vessel growth. Cardiovasc Res. 2001;49(3):507–521. doi: 10.1016/s0008-6363(00)00281-9 EDN: IMYHNF
13. Park H, Jung W, Kim J, Lim K. Twelve weeks of exercise modality in hypoxia enhances health-related function in obese older Korean men: A randomized controlled trial. Geriatr Gerontol Int. 2019;19(4):311–316. doi: 10.1111/ggi.13620 EDN: XADUWJ
14. Kong Z, Shi Q, Nie J, et al. High-Intensity Interval Training in Normobaric Hypoxia Improves Cardiorespiratory Fitness in Overweight Chinese Young Women. Front Physiol. 2017;8:175. doi: 10.3389/fphys.2017.00175
15. Pramsohler S, Burtscher M, Faulhaber M, et al. Endurance Training in Normobaric Hypoxia Imposes Less Physical Stress for Geriatric Rehabilitation. Front Physiol. 2017;8:514. doi: 10.3389/fphys.2017.00514 EDN: YFWOTS
16. Lizamore CA, Hamlin MJ. The Use of Simulated Altitude Techniques for Beneficial Cardiovascular Health Outcomes in Nonathletic, Sedentary, and Clinical Populations: A Literature Review. High Alt Med Biol. 2017;18(4):305–321. doi: 10.1089/ham.2017.0050 EDN: VFKNRC
17. Glazachev OS, Pozdnyakov YuM, Urinsky AM, Zabashta SP. Hypoxia-hyperoxia adaptation and increased exercise capacity in patients with coronary heart disease. Cardiovascular Therapy and Prevention. 2014;13(1):16–21. doi: 10.15829/1728-8800-2014-1-16-21 EDN: RZDWHZ
18. Thygesen K, Alpert JS, Jaffe AS, et al. Fourth universal definition of myocardial infarction (2018). Russ J Cardiol. 2019;24(3):107–138. doi: 10.15829/1560-4071-2019-3-107-138 EDN: ZAQSQP
19. Nasreddine ZS, Phillips NA, Bédirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695–699. doi: 10.1111/j.1532-5415.2005.53221.x
20. Nagayama D, Shirai K, Saiki A. Significance of CAVI as a functional stiffness parameter: beyond the prognostic value for cardiovascular events. J Am Coll Cardiol. 2024;83(17):101018. doi: 10.1016/j.jacadv.2024.101018 EDN: TFSRSK
21. Sairaku A, Eno S, Hondo T, et al. Head-to-head comparison of the cardio-ankle vascular index between patients with acute coronary syndrome and stable angina pectoris. Hypertens Res. 2010;33(11):1162–1166. doi: 10.1038/hr.2010.141
22. Takaki A, Ogawa H, Wakeyama T, et al. Cardio-ankle vascular index is superior to brachial-ankle pulse wave velocity as an index of arterial stiffness. Hypertens Res. 2008;31(7):1347–1355. doi: 10.1291/hypres.31.1347
23. Miyoshi T, Ito H. Assessment of arterial stiffness using the cardio-ankle vascular index. Pulse (Basel). 2016;4(1):11–23. doi: 10.1159/000445214
24. Shirai K, Utino J, Otsuka K, Takata M. A novel blood pressure-independent arterial wall stiffness parameter; cardio-ankle vascular index (CAVI). J Atheroscler Thromb. 2006;13(2):101–107. doi: 10.5551/jat.13.101
25. Namba T, Adachi T, Masaki N, Takase B. Arterial stiffness assessed by Cardio-Ankle vascular index. Int J Mol Sci. 2019;20(15):3664. doi: 10.3390/ijms20153664 EDN: NYIBGZ
26. Rooke TW, Hirsch AT, Misra S, et al. 2011 ACCF/AHA focused update of the guideline for the management of patients with peripheral artery disease (updating the 2005 guideline) a report of the American college of cardiology foundation/American heart association task force on practice guidelines. Circulation. 2011;124(18):2020–2045. doi: 10.1161/CIR.0b013e31822e80c3
27. Glazachev OS, Kryzhanovskaya SY, Zapara MA, et al. Safety and Efficacy of Intermittent Hypoxia Conditioning as a New Rehabilitation/ Secondary Prevention Strategy for Patients with Cardiovascular Diseases: A Systematic Review and Meta-analysis. Curr Cardiol Rev. 2021;17(6):e051121193317. doi: 10.2174/1573403X17666210514005235 EDN: CMJNPI
28. Karamova IM, Kuzmina ZS, Abdyukova ER, Stolyarova TV, Goldobina LP. Application of interval hypoxic training at the second inpatient stage of rehabilitation of patients with myocardial infarction without Q-wave in the subacute period. CardioSomatics. 2017;8(1):40. doi: 10.26442/CS45531 EDN: ZIFAMJ
29. Bayer U, Glazachev OS, Likar R, et al. Adaptation to intermittent hypoxia-hyperoxia improves cognitive performance and exercise tolerance in elderly. Advances in Gerontology. 2017;30(2):255–261. EDN: YQGBYD
30. Bayer U, Likar R, Pinter G, et al. Intermittent hypoxic-hyperoxic training on cognitive performance in geriatric patients. Alzheimers Dement (N Y). 2017;3(1):114–122. doi: 10.1016/j.trci.2017.01.002 EDN: YVDPHJ
31. Thong EHE, Quek EJW, Loo JH, et al. Acute Myocardial Infarction and Risk of Cognitive Impairment and Dementia: A Review. Biology (Basel). 2023;12(8):1154. doi: 10.3390/biology12081154 EDN: XMMALC
32. Bestavashvili AA. The effect of hypoxic-hyperoxic preconditioning on vascular stiffness and liver tissue elasticity in patients with metabolic syndrome. In: Contradictions in modern cardiology: "Controversial and unresolved issues" 7th All-Russian Conference; 2014 Oct 19-20; Samara Russia. (In Russ.)
2. Zhao E, Lowres N, Woolaston A, et al. Prevalence and patterns of cognitive impairment in acute coronary syndrome patients: A systematic review. Eur J Prev Cardiol. 2020;27(3):284–293. doi: 10.1177/2047487319878945 EDN: XOUQPO
3. Petrova MM, Leiman AR, Ustyugov SA, Schneider NA, Petrov AV. Vascular cognitive impairment in patients after acute myocardial infarction. Russian Journal of Cardiology. 2025;30(6S):6087. doi: 10.15829/1560-4071-2025-6087 EDN: MPFWGC
4. Yuan SM, Lin H. Postoperative Cognitive Dysfunction after Coronary Artery Bypass Grafting. Brazilian Journal of Cardiovascular Surgery. 2019;34(1):76–84. doi: 10.21470/1678-9741-2018-0165 EDN: OGBQMG
5. Gu SZ, Beska B, Chan D, et al. Cognitive Decline in Older Patients with Non-ST Elevation Acute Coronary Syndrome. J Am Heart Assoc. 2019;8(15):e011218. doi: 10.1161/JAHA.118.011218
6. Weber B, Bersch-Ferreira ÂC, Torreglosa CR, et al. Implementation of a Brazilian Cardioprotective Nutritional (BALANCE) Program for improvement on quality of diet and secondary prevention of cardiovascular events: A randomized, multicenter trial. Am Heart J. 2019;215:187–197. doi: 10.1016/j.ahj.2019.06.007 EDN: VKLTKO
7. Grässler B, Thielmann B, Böckelmann I, Hökelmann A. Effects of different exercise interventions on cardiac autonomic control and secondary health factors in middle-aged adults: A Systematic Review. J Cardiovasc Dev Dis. 2021;8(8):94. doi: 10.3390/jcdd8080094 EDN: XXCPMI
8. Mansilla-Chacón M, Gómez-Urquiza JL, Martos-Cabrera MB, et al. Effects of Supervised Cardiac Rehabilitation Programmes on Quality of Life among Myocardial Infarction Patients: A Systematic Review and Meta‑Analysis. J Cardiovasc Dev Dis. 2021;8(12):166. doi: 10.3390/jcdd8120166 EDN: IIODSM
9. Uryasiev OM, Isaeva IA. Intravenous lasertherapy and interval normobaric hypoxytherapy effectiveness in asthma and comorbid essential hypertension complex therapy. Zemskii vrach. 2014;(3-4(24)):25–28. EDN: TAWVTD
10. Isaeva IA, Uryasiev OM, Chuntyzheva EG, Pristupa AS. Effectiveness of application of complexes of physical factors in patients with bronchial asthma and comorbid essential hypertension. Nauka molodykh (Eruditio Juvenium). 2018;(1). doi: 10.23888/HMJ2018163-73 EDN: YVKBSU
11. Neubauer JA. Invited review: Physiological and pathophysiological responses to intermittent hypoxia. J Appl Physiol (1985). 2001;90(4):1593–1599. doi: 10.1152/jappl.2001.90.4.1593 EDN: XORQYZ
12. Conway EM, Collen D, Carmeliet P. Molecular mechanisms of blood vessel growth. Cardiovasc Res. 2001;49(3):507–521. doi: 10.1016/s0008-6363(00)00281-9 EDN: IMYHNF
13. Park H, Jung W, Kim J, Lim K. Twelve weeks of exercise modality in hypoxia enhances health-related function in obese older Korean men: A randomized controlled trial. Geriatr Gerontol Int. 2019;19(4):311–316. doi: 10.1111/ggi.13620 EDN: XADUWJ
14. Kong Z, Shi Q, Nie J, et al. High-Intensity Interval Training in Normobaric Hypoxia Improves Cardiorespiratory Fitness in Overweight Chinese Young Women. Front Physiol. 2017;8:175. doi: 10.3389/fphys.2017.00175
15. Pramsohler S, Burtscher M, Faulhaber M, et al. Endurance Training in Normobaric Hypoxia Imposes Less Physical Stress for Geriatric Rehabilitation. Front Physiol. 2017;8:514. doi: 10.3389/fphys.2017.00514 EDN: YFWOTS
16. Lizamore CA, Hamlin MJ. The Use of Simulated Altitude Techniques for Beneficial Cardiovascular Health Outcomes in Nonathletic, Sedentary, and Clinical Populations: A Literature Review. High Alt Med Biol. 2017;18(4):305–321. doi: 10.1089/ham.2017.0050 EDN: VFKNRC
17. Glazachev OS, Pozdnyakov YuM, Urinsky AM, Zabashta SP. Hypoxia-hyperoxia adaptation and increased exercise capacity in patients with coronary heart disease. Cardiovascular Therapy and Prevention. 2014;13(1):16–21. doi: 10.15829/1728-8800-2014-1-16-21 EDN: RZDWHZ
18. Thygesen K, Alpert JS, Jaffe AS, et al. Fourth universal definition of myocardial infarction (2018). Russ J Cardiol. 2019;24(3):107–138. doi: 10.15829/1560-4071-2019-3-107-138 EDN: ZAQSQP
19. Nasreddine ZS, Phillips NA, Bédirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695–699. doi: 10.1111/j.1532-5415.2005.53221.x
20. Nagayama D, Shirai K, Saiki A. Significance of CAVI as a functional stiffness parameter: beyond the prognostic value for cardiovascular events. J Am Coll Cardiol. 2024;83(17):101018. doi: 10.1016/j.jacadv.2024.101018 EDN: TFSRSK
21. Sairaku A, Eno S, Hondo T, et al. Head-to-head comparison of the cardio-ankle vascular index between patients with acute coronary syndrome and stable angina pectoris. Hypertens Res. 2010;33(11):1162–1166. doi: 10.1038/hr.2010.141
22. Takaki A, Ogawa H, Wakeyama T, et al. Cardio-ankle vascular index is superior to brachial-ankle pulse wave velocity as an index of arterial stiffness. Hypertens Res. 2008;31(7):1347–1355. doi: 10.1291/hypres.31.1347
23. Miyoshi T, Ito H. Assessment of arterial stiffness using the cardio-ankle vascular index. Pulse (Basel). 2016;4(1):11–23. doi: 10.1159/000445214
24. Shirai K, Utino J, Otsuka K, Takata M. A novel blood pressure-independent arterial wall stiffness parameter; cardio-ankle vascular index (CAVI). J Atheroscler Thromb. 2006;13(2):101–107. doi: 10.5551/jat.13.101
25. Namba T, Adachi T, Masaki N, Takase B. Arterial stiffness assessed by Cardio-Ankle vascular index. Int J Mol Sci. 2019;20(15):3664. doi: 10.3390/ijms20153664 EDN: NYIBGZ
26. Rooke TW, Hirsch AT, Misra S, et al. 2011 ACCF/AHA focused update of the guideline for the management of patients with peripheral artery disease (updating the 2005 guideline) a report of the American college of cardiology foundation/American heart association task force on practice guidelines. Circulation. 2011;124(18):2020–2045. doi: 10.1161/CIR.0b013e31822e80c3
27. Glazachev OS, Kryzhanovskaya SY, Zapara MA, et al. Safety and Efficacy of Intermittent Hypoxia Conditioning as a New Rehabilitation/ Secondary Prevention Strategy for Patients with Cardiovascular Diseases: A Systematic Review and Meta-analysis. Curr Cardiol Rev. 2021;17(6):e051121193317. doi: 10.2174/1573403X17666210514005235 EDN: CMJNPI
28. Karamova IM, Kuzmina ZS, Abdyukova ER, Stolyarova TV, Goldobina LP. Application of interval hypoxic training at the second inpatient stage of rehabilitation of patients with myocardial infarction without Q-wave in the subacute period. CardioSomatics. 2017;8(1):40. doi: 10.26442/CS45531 EDN: ZIFAMJ
29. Bayer U, Glazachev OS, Likar R, et al. Adaptation to intermittent hypoxia-hyperoxia improves cognitive performance and exercise tolerance in elderly. Advances in Gerontology. 2017;30(2):255–261. EDN: YQGBYD
30. Bayer U, Likar R, Pinter G, et al. Intermittent hypoxic-hyperoxic training on cognitive performance in geriatric patients. Alzheimers Dement (N Y). 2017;3(1):114–122. doi: 10.1016/j.trci.2017.01.002 EDN: YVDPHJ
31. Thong EHE, Quek EJW, Loo JH, et al. Acute Myocardial Infarction and Risk of Cognitive Impairment and Dementia: A Review. Biology (Basel). 2023;12(8):1154. doi: 10.3390/biology12081154 EDN: XMMALC
32. Bestavashvili AA. The effect of hypoxic-hyperoxic preconditioning on vascular stiffness and liver tissue elasticity in patients with metabolic syndrome. In: Contradictions in modern cardiology: "Controversial and unresolved issues" 7th All-Russian Conference; 2014 Oct 19-20; Samara Russia. (In Russ.)
2. Zhao E, Lowres N, Woolaston A, et al. Prevalence and patterns of cognitive impairment in acute coronary syndrome patients: A systematic review. Eur J Prev Cardiol. 2020;27(3):284–293. doi: 10.1177/2047487319878945 EDN: XOUQPO
3. Petrova MM, Leiman AR, Ustyugov SA, Schneider NA, Petrov AV. Vascular cognitive impairment in patients after acute myocardial infarction. Russian Journal of Cardiology. 2025;30(6S):6087. doi: 10.15829/1560-4071-2025-6087 EDN: MPFWGC
4. Yuan SM, Lin H. Postoperative Cognitive Dysfunction after Coronary Artery Bypass Grafting. Brazilian Journal of Cardiovascular Surgery. 2019;34(1):76–84. doi: 10.21470/1678-9741-2018-0165 EDN: OGBQMG
5. Gu SZ, Beska B, Chan D, et al. Cognitive Decline in Older Patients with Non-ST Elevation Acute Coronary Syndrome. J Am Heart Assoc. 2019;8(15):e011218. doi: 10.1161/JAHA.118.011218
6. Weber B, Bersch-Ferreira ÂC, Torreglosa CR, et al. Implementation of a Brazilian Cardioprotective Nutritional (BALANCE) Program for improvement on quality of diet and secondary prevention of cardiovascular events: A randomized, multicenter trial. Am Heart J. 2019;215:187–197. doi: 10.1016/j.ahj.2019.06.007 EDN: VKLTKO
7. Grässler B, Thielmann B, Böckelmann I, Hökelmann A. Effects of different exercise interventions on cardiac autonomic control and secondary health factors in middle-aged adults: A Systematic Review. J Cardiovasc Dev Dis. 2021;8(8):94. doi: 10.3390/jcdd8080094 EDN: XXCPMI
8. Mansilla-Chacón M, Gómez-Urquiza JL, Martos-Cabrera MB, et al. Effects of Supervised Cardiac Rehabilitation Programmes on Quality of Life among Myocardial Infarction Patients: A Systematic Review and Meta‑Analysis. J Cardiovasc Dev Dis. 2021;8(12):166. doi: 10.3390/jcdd8120166 EDN: IIODSM
9. Uryasiev OM, Isaeva IA. Intravenous lasertherapy and interval normobaric hypoxytherapy effectiveness in asthma and comorbid essential hypertension complex therapy. Zemskii vrach. 2014;(3-4(24)):25–28. EDN: TAWVTD
10. Isaeva IA, Uryasiev OM, Chuntyzheva EG, Pristupa AS. Effectiveness of application of complexes of physical factors in patients with bronchial asthma and comorbid essential hypertension. Nauka molodykh (Eruditio Juvenium). 2018;(1). doi: 10.23888/HMJ2018163-73 EDN: YVKBSU
11. Neubauer JA. Invited review: Physiological and pathophysiological responses to intermittent hypoxia. J Appl Physiol (1985). 2001;90(4):1593–1599. doi: 10.1152/jappl.2001.90.4.1593 EDN: XORQYZ
12. Conway EM, Collen D, Carmeliet P. Molecular mechanisms of blood vessel growth. Cardiovasc Res. 2001;49(3):507–521. doi: 10.1016/s0008-6363(00)00281-9 EDN: IMYHNF
13. Park H, Jung W, Kim J, Lim K. Twelve weeks of exercise modality in hypoxia enhances health-related function in obese older Korean men: A randomized controlled trial. Geriatr Gerontol Int. 2019;19(4):311–316. doi: 10.1111/ggi.13620 EDN: XADUWJ
14. Kong Z, Shi Q, Nie J, et al. High-Intensity Interval Training in Normobaric Hypoxia Improves Cardiorespiratory Fitness in Overweight Chinese Young Women. Front Physiol. 2017;8:175. doi: 10.3389/fphys.2017.00175
15. Pramsohler S, Burtscher M, Faulhaber M, et al. Endurance Training in Normobaric Hypoxia Imposes Less Physical Stress for Geriatric Rehabilitation. Front Physiol. 2017;8:514. doi: 10.3389/fphys.2017.00514 EDN: YFWOTS
16. Lizamore CA, Hamlin MJ. The Use of Simulated Altitude Techniques for Beneficial Cardiovascular Health Outcomes in Nonathletic, Sedentary, and Clinical Populations: A Literature Review. High Alt Med Biol. 2017;18(4):305–321. doi: 10.1089/ham.2017.0050 EDN: VFKNRC
17. Glazachev OS, Pozdnyakov YuM, Urinsky AM, Zabashta SP. Hypoxia-hyperoxia adaptation and increased exercise capacity in patients with coronary heart disease. Cardiovascular Therapy and Prevention. 2014;13(1):16–21. doi: 10.15829/1728-8800-2014-1-16-21 EDN: RZDWHZ
18. Thygesen K, Alpert JS, Jaffe AS, et al. Fourth universal definition of myocardial infarction (2018). Russ J Cardiol. 2019;24(3):107–138. doi: 10.15829/1560-4071-2019-3-107-138 EDN: ZAQSQP
19. Nasreddine ZS, Phillips NA, Bédirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695–699. doi: 10.1111/j.1532-5415.2005.53221.x
20. Nagayama D, Shirai K, Saiki A. Significance of CAVI as a functional stiffness parameter: beyond the prognostic value for cardiovascular events. J Am Coll Cardiol. 2024;83(17):101018. doi: 10.1016/j.jacadv.2024.101018 EDN: TFSRSK
21. Sairaku A, Eno S, Hondo T, et al. Head-to-head comparison of the cardio-ankle vascular index between patients with acute coronary syndrome and stable angina pectoris. Hypertens Res. 2010;33(11):1162–1166. doi: 10.1038/hr.2010.141
22. Takaki A, Ogawa H, Wakeyama T, et al. Cardio-ankle vascular index is superior to brachial-ankle pulse wave velocity as an index of arterial stiffness. Hypertens Res. 2008;31(7):1347–1355. doi: 10.1291/hypres.31.1347
23. Miyoshi T, Ito H. Assessment of arterial stiffness using the cardio-ankle vascular index. Pulse (Basel). 2016;4(1):11–23. doi: 10.1159/000445214
24. Shirai K, Utino J, Otsuka K, Takata M. A novel blood pressure-independent arterial wall stiffness parameter; cardio-ankle vascular index (CAVI). J Atheroscler Thromb. 2006;13(2):101–107. doi: 10.5551/jat.13.101
25. Namba T, Adachi T, Masaki N, Takase B. Arterial stiffness assessed by Cardio-Ankle vascular index. Int J Mol Sci. 2019;20(15):3664. doi: 10.3390/ijms20153664 EDN: NYIBGZ
26. Rooke TW, Hirsch AT, Misra S, et al. 2011 ACCF/AHA focused update of the guideline for the management of patients with peripheral artery disease (updating the 2005 guideline) a report of the American college of cardiology foundation/American heart association task force on practice guidelines. Circulation. 2011;124(18):2020–2045. doi: 10.1161/CIR.0b013e31822e80c3
27. Glazachev OS, Kryzhanovskaya SY, Zapara MA, et al. Safety and Efficacy of Intermittent Hypoxia Conditioning as a New Rehabilitation/ Secondary Prevention Strategy for Patients with Cardiovascular Diseases: A Systematic Review and Meta-analysis. Curr Cardiol Rev. 2021;17(6):e051121193317. doi: 10.2174/1573403X17666210514005235 EDN: CMJNPI
28. Karamova IM, Kuzmina ZS, Abdyukova ER, Stolyarova TV, Goldobina LP. Application of interval hypoxic training at the second inpatient stage of rehabilitation of patients with myocardial infarction without Q-wave in the subacute period. CardioSomatics. 2017;8(1):40. doi: 10.26442/CS45531 EDN: ZIFAMJ
29. Bayer U, Glazachev OS, Likar R, et al. Adaptation to intermittent hypoxia-hyperoxia improves cognitive performance and exercise tolerance in elderly. Advances in Gerontology. 2017;30(2):255–261. EDN: YQGBYD
30. Bayer U, Likar R, Pinter G, et al. Intermittent hypoxic-hyperoxic training on cognitive performance in geriatric patients. Alzheimers Dement (N Y). 2017;3(1):114–122. doi: 10.1016/j.trci.2017.01.002 EDN: YVDPHJ
31. Thong EHE, Quek EJW, Loo JH, et al. Acute Myocardial Infarction and Risk of Cognitive Impairment and Dementia: A Review. Biology (Basel). 2023;12(8):1154. doi: 10.3390/biology12081154 EDN: XMMALC
32. Bestavashvili AA. The effect of hypoxic-hyperoxic preconditioning on vascular stiffness and liver tissue elasticity in patients with metabolic syndrome. In: Contradictions in modern cardiology: "Controversial and unresolved issues" 7th All-Russian Conference; 2014 Oct 19-20; Samara Russia. (In Russ.)
________________________________________________
2. Zhao E, Lowres N, Woolaston A, et al. Prevalence and patterns of cognitive impairment in acute coronary syndrome patients: A systematic review. Eur J Prev Cardiol. 2020;27(3):284–293. doi: 10.1177/2047487319878945 EDN: XOUQPO
3. Petrova MM, Leiman AR, Ustyugov SA, Schneider NA, Petrov AV. Vascular cognitive impairment in patients after acute myocardial infarction. Russian Journal of Cardiology. 2025;30(6S):6087. doi: 10.15829/1560-4071-2025-6087 EDN: MPFWGC
4. Yuan SM, Lin H. Postoperative Cognitive Dysfunction after Coronary Artery Bypass Grafting. Brazilian Journal of Cardiovascular Surgery. 2019;34(1):76–84. doi: 10.21470/1678-9741-2018-0165 EDN: OGBQMG
5. Gu SZ, Beska B, Chan D, et al. Cognitive Decline in Older Patients with Non-ST Elevation Acute Coronary Syndrome. J Am Heart Assoc. 2019;8(15):e011218. doi: 10.1161/JAHA.118.011218
6. Weber B, Bersch-Ferreira ÂC, Torreglosa CR, et al. Implementation of a Brazilian Cardioprotective Nutritional (BALANCE) Program for improvement on quality of diet and secondary prevention of cardiovascular events: A randomized, multicenter trial. Am Heart J. 2019;215:187–197. doi: 10.1016/j.ahj.2019.06.007 EDN: VKLTKO
7. Grässler B, Thielmann B, Böckelmann I, Hökelmann A. Effects of different exercise interventions on cardiac autonomic control and secondary health factors in middle-aged adults: A Systematic Review. J Cardiovasc Dev Dis. 2021;8(8):94. doi: 10.3390/jcdd8080094 EDN: XXCPMI
8. Mansilla-Chacón M, Gómez-Urquiza JL, Martos-Cabrera MB, et al. Effects of Supervised Cardiac Rehabilitation Programmes on Quality of Life among Myocardial Infarction Patients: A Systematic Review and Meta‑Analysis. J Cardiovasc Dev Dis. 2021;8(12):166. doi: 10.3390/jcdd8120166 EDN: IIODSM
9. Uryasiev OM, Isaeva IA. Intravenous lasertherapy and interval normobaric hypoxytherapy effectiveness in asthma and comorbid essential hypertension complex therapy. Zemskii vrach. 2014;(3-4(24)):25–28. EDN: TAWVTD
10. Isaeva IA, Uryasiev OM, Chuntyzheva EG, Pristupa AS. Effectiveness of application of complexes of physical factors in patients with bronchial asthma and comorbid essential hypertension. Nauka molodykh (Eruditio Juvenium). 2018;(1). doi: 10.23888/HMJ2018163-73 EDN: YVKBSU
11. Neubauer JA. Invited review: Physiological and pathophysiological responses to intermittent hypoxia. J Appl Physiol (1985). 2001;90(4):1593–1599. doi: 10.1152/jappl.2001.90.4.1593 EDN: XORQYZ
12. Conway EM, Collen D, Carmeliet P. Molecular mechanisms of blood vessel growth. Cardiovasc Res. 2001;49(3):507–521. doi: 10.1016/s0008-6363(00)00281-9 EDN: IMYHNF
13. Park H, Jung W, Kim J, Lim K. Twelve weeks of exercise modality in hypoxia enhances health-related function in obese older Korean men: A randomized controlled trial. Geriatr Gerontol Int. 2019;19(4):311–316. doi: 10.1111/ggi.13620 EDN: XADUWJ
14. Kong Z, Shi Q, Nie J, et al. High-Intensity Interval Training in Normobaric Hypoxia Improves Cardiorespiratory Fitness in Overweight Chinese Young Women. Front Physiol. 2017;8:175. doi: 10.3389/fphys.2017.00175
15. Pramsohler S, Burtscher M, Faulhaber M, et al. Endurance Training in Normobaric Hypoxia Imposes Less Physical Stress for Geriatric Rehabilitation. Front Physiol. 2017;8:514. doi: 10.3389/fphys.2017.00514 EDN: YFWOTS
16. Lizamore CA, Hamlin MJ. The Use of Simulated Altitude Techniques for Beneficial Cardiovascular Health Outcomes in Nonathletic, Sedentary, and Clinical Populations: A Literature Review. High Alt Med Biol. 2017;18(4):305–321. doi: 10.1089/ham.2017.0050 EDN: VFKNRC
17. Glazachev OS, Pozdnyakov YuM, Urinsky AM, Zabashta SP. Hypoxia-hyperoxia adaptation and increased exercise capacity in patients with coronary heart disease. Cardiovascular Therapy and Prevention. 2014;13(1):16–21. doi: 10.15829/1728-8800-2014-1-16-21 EDN: RZDWHZ
18. Thygesen K, Alpert JS, Jaffe AS, et al. Fourth universal definition of myocardial infarction (2018). Russ J Cardiol. 2019;24(3):107–138. doi: 10.15829/1560-4071-2019-3-107-138 EDN: ZAQSQP
19. Nasreddine ZS, Phillips NA, Bédirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695–699. doi: 10.1111/j.1532-5415.2005.53221.x
20. Nagayama D, Shirai K, Saiki A. Significance of CAVI as a functional stiffness parameter: beyond the prognostic value for cardiovascular events. J Am Coll Cardiol. 2024;83(17):101018. doi: 10.1016/j.jacadv.2024.101018 EDN: TFSRSK
21. Sairaku A, Eno S, Hondo T, et al. Head-to-head comparison of the cardio-ankle vascular index between patients with acute coronary syndrome and stable angina pectoris. Hypertens Res. 2010;33(11):1162–1166. doi: 10.1038/hr.2010.141
22. Takaki A, Ogawa H, Wakeyama T, et al. Cardio-ankle vascular index is superior to brachial-ankle pulse wave velocity as an index of arterial stiffness. Hypertens Res. 2008;31(7):1347–1355. doi: 10.1291/hypres.31.1347
23. Miyoshi T, Ito H. Assessment of arterial stiffness using the cardio-ankle vascular index. Pulse (Basel). 2016;4(1):11–23. doi: 10.1159/000445214
24. Shirai K, Utino J, Otsuka K, Takata M. A novel blood pressure-independent arterial wall stiffness parameter; cardio-ankle vascular index (CAVI). J Atheroscler Thromb. 2006;13(2):101–107. doi: 10.5551/jat.13.101
25. Namba T, Adachi T, Masaki N, Takase B. Arterial stiffness assessed by Cardio-Ankle vascular index. Int J Mol Sci. 2019;20(15):3664. doi: 10.3390/ijms20153664 EDN: NYIBGZ
26. Rooke TW, Hirsch AT, Misra S, et al. 2011 ACCF/AHA focused update of the guideline for the management of patients with peripheral artery disease (updating the 2005 guideline) a report of the American college of cardiology foundation/American heart association task force on practice guidelines. Circulation. 2011;124(18):2020–2045. doi: 10.1161/CIR.0b013e31822e80c3
27. Glazachev OS, Kryzhanovskaya SY, Zapara MA, et al. Safety and Efficacy of Intermittent Hypoxia Conditioning as a New Rehabilitation/ Secondary Prevention Strategy for Patients with Cardiovascular Diseases: A Systematic Review and Meta-analysis. Curr Cardiol Rev. 2021;17(6):e051121193317. doi: 10.2174/1573403X17666210514005235 EDN: CMJNPI
28. Karamova IM, Kuzmina ZS, Abdyukova ER, Stolyarova TV, Goldobina LP. Application of interval hypoxic training at the second inpatient stage of rehabilitation of patients with myocardial infarction without Q-wave in the subacute period. CardioSomatics. 2017;8(1):40. doi: 10.26442/CS45531 EDN: ZIFAMJ
29. Bayer U, Glazachev OS, Likar R, et al. Adaptation to intermittent hypoxia-hyperoxia improves cognitive performance and exercise tolerance in elderly. Advances in Gerontology. 2017;30(2):255–261. EDN: YQGBYD
30. Bayer U, Likar R, Pinter G, et al. Intermittent hypoxic-hyperoxic training on cognitive performance in geriatric patients. Alzheimers Dement (N Y). 2017;3(1):114–122. doi: 10.1016/j.trci.2017.01.002 EDN: YVDPHJ
31. Thong EHE, Quek EJW, Loo JH, et al. Acute Myocardial Infarction and Risk of Cognitive Impairment and Dementia: A Review. Biology (Basel). 2023;12(8):1154. doi: 10.3390/biology12081154 EDN: XMMALC
32. Bestavashvili AA. The effect of hypoxic-hyperoxic preconditioning on vascular stiffness and liver tissue elasticity in patients with metabolic syndrome. In: Contradictions in modern cardiology: "Controversial and unresolved issues" 7th All-Russian Conference; 2014 Oct 19-20; Samara Russia. (In Russ.)
Авторы
А.В. Андреева*1, Ю.А. Андреева2, С.С. Якушин2, Н.П. Лямина3
1Областной клинический кардиологический диспансер, Рязань, Россия;
2Рязанский государственный медицинский университет имени академика И.П. Павлова, Рязань, Россия;
3Московский областной научно-исследовательский клинический институт имени М.Ф. Владимирского, Москва, Россия
*andreeva_anna76@mail.ru
1Regional Clinical Cardiology Dispensary, Ryazan, Russia;
2Ryazan State Medical University, Ryazan, Russia;
3Moscow Regional Research and Clinical Institute, Moscow, Russia
*andreeva_anna76@mail.ru
1Областной клинический кардиологический диспансер, Рязань, Россия;
2Рязанский государственный медицинский университет имени академика И.П. Павлова, Рязань, Россия;
3Московский областной научно-исследовательский клинический институт имени М.Ф. Владимирского, Москва, Россия
*andreeva_anna76@mail.ru
________________________________________________
1Regional Clinical Cardiology Dispensary, Ryazan, Russia;
2Ryazan State Medical University, Ryazan, Russia;
3Moscow Regional Research and Clinical Institute, Moscow, Russia
*andreeva_anna76@mail.ru
Цель портала OmniDoctor – предоставление профессиональной информации врачам, провизорам и фармацевтам.