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Значение макро- и микроэлементов пищи в оптимизации минеральной плотности костной ткани
Значение макро- и микроэлементов пищи в оптимизации минеральной плотности костной ткани
Погожева А.В. Значение макро- и микроэлементов пищи в оптимизации минеральной плотности костной ткани.Consilium Medicum. 2015; 17 (2): 61–65. DOI: 10.26442/2075-1753_2015.2.61-65
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Аннотация
В настоящее время весьма актуальной является проблема дефицита макро- и микроэлементов, который способствует развитию разных патологических состояний, в том числе остеопороза и остеопении. В обзоре рассмотрены результаты клинических и экспериментальных исследований, доказывающие необходимость алиментарной коррекции дефицита макро- и микроэлементов с помощью применения витаминно-минеральных комплексов, содержащих остеотропные минералы (магний, цинк, медь, марганец, бор), для профилактики и лечения остеопении и остеопороза.
Ключевые слова: остеопения, остеопороз, минеральная плотность костной ткани, остеотропные макро- и микроэлементы.
Ключевые слова: остеопения, остеопороз, минеральная плотность костной ткани, остеотропные макро- и микроэлементы.
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At the present time, the shortage of macro- and microelements, which contributes to the development of various pathological conditions, including osteoporosis and osteopenia is a very topical problem. In this review the results of clinical and experimental studies that prove the necessity of nutritional deficiency correction of macro- and micronutrients through the use of vitamin-mineral complexes containing osteotrophic minerals (magnesium, zinc, copper, manganese, boron) for the prevention and treatment of osteopenia and osteoporosis are presented and discussed.
Key words: osteopenia, osteoporosis, bone mineral density, osteotrophic macro- and microelements.
Key words: osteopenia, osteoporosis, bone mineral density, osteotrophic macro- and microelements.
Полный текст
Список литературы
1. Аникин С.Г., Беневоленская Л.И. Остеопороз и кардиоваскулярные заболевания. Науч.-практ. ревматология. 2006; 5: 39–45. / Anikin S.G., Benevolenskaia L.I. Osteoporoz i kardiovaskuliarnye zabolevaniia. Nauch.-prakt. revmatologiia. 2006; 5: 39–45. [in Russian]
2. Беневоленская Л.И., Никитинская О.А., Торопцова Н.В. Фармакологическая профилактика первичного остеопороза. РМЖ. 2008; 16 (6): 409–14. / Benevolenskaia L.I., Nikitinskaia O.A., Toroptsova N.V. Farmakologicheskaia profilaktika pervichnogo osteoporoza. RMZh. 2008; 16 (6): 409–14. [in Russian]
3. Оглоблин Н.А., Вржесинская О.А., Коденцова В.М. и др. Обеспеченность больных, страдающих сердечно-сосудистыми заболеваниями, витаминами и минеральными веществами. Вопр. питания. 2007; 76 (1): 31–8. / Ogloblin N.A., Vrzhesinskaia O.A., Kodentsova V.M. i dr. Obespechennost' bol'nykh, stradaiushchikh serdechno-sosudistymi zabolevaniiami, vitaminami i mineral'nymi veshchestvami. Vopr. pitaniia. 2007; 76 (1): 31–8. [in Russian]
4. Оглоблин Н.А., Спиричев В.Б., Батурин А.К. О потреблении населением России кальция с пищей. Вопр. питания. 2005; 5: 14–7. / Ogloblin N.A., Spirichev V.B., Baturin A.K. O potreblenii naseleniem Rossii kal'tsiia s pishchei. Vopr. pitaniia. 2005; 5: 14–7. [in Russian]
5. Светикова А.А., Коденцова В.М., Вржесинская О.А. и др. Особенности минерализации костной ткани у больных с сердечно-сосудистой и желудочно-кишечной патологией и обеспеченность их витаминами и кальцием. Вопр. питания. 2008; 1: 20–25. / Svetikova A.A., Kodentsova V.M., Vrzhesinskaia O.A. i dr. Osobennosti mineralizatsii kostnoi tkani u bol'nykh s serdechno-sosudistoi i zheludochno-kishechnoi patologiei i obespechennost' ikh vitaminami i kal'tsiem. Vopr. pitaniia. 2008; 1: 20–25. [in Russian]
6. Светикова А.А., Вржесинская О.А., Коденцова В.М. и др. Витаминный статус и минеральная плотность костной ткани у больных с ожирением и сердечно-сосудистой патологией. Вопр. питания. 2008; 3: 39–44. / Svetikova A.A., Vrzhesinskaia O.A., Kodentsova V.M. i dr. Vitaminnyi status i mineral'naia plotnost' kostnoi tkani u bol'nykh s ozhireniem i serdechno-sosudistoi patologiei. Vopr. pitaniia. 2008; 3: 39–44. [in Russian]
7. Baldini V, Mastropasqua M, Francucci CM, D'Erasmo E. Cardiovascular disease and osteoporosis. J Endocrinol Invest 2005; 28 (10): 69–72.
8. Bolton-Smith С, McMurdo М, Paterson СR et al. Two-Year Randomized Controlled Trial of Vitamin K1 (Phylloquinone) and Vitamin D3 Plus Calcium on the Bone Health of Older Women. J Bone Miner Res 2007; 22: 509–19.
9. Gnudi S, Sitta E, Fiumi N. Relationship between body composition and bone mineral density in women with and without osteoporosis: relative contribution of lean and fat mass. J Bone Miner Metab 2007; 25 (5): 326–32.
10. Jurutka PW, Bartik L, Whitfield GK et al. Vitamin D receptor: key roles in bone mineral pathophysiology, molecular mechanism of action, and novel nutritional ligands. J Bone Miner Res 2007; 22 (2): 2–10.
11. Mitra S, Desai M, Ikram Khatkhatay M. Vitamin D receptor gene polymorphisms and bone mineral den-sity in postmenopausal Indian women. Maturitas 2006; 55 (1): 27–35.
12. Rejnmark L, Lauridsen A, Vestergaard P et al. Vitamin D Status: long-term variability in postmenopausal women. A Follow Up Study. J Bone Miner Res 2004; 578.
13. Ribaya-Mercado JD, Blumberg GB. Vitamin A: is it a risk factor for osteoporosis and bone fracture? Nutr Rev 2007; 65 (10): 425–38.
14. Villadsen MM, Bunger MH, Carstens M et al. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with osteoporotic vertebral fractures, but is a weak predictor of BMD. Osteoporos Int 2005; 16 (4): 411–6.
15. Yazdanpanah N, Uitterlinden AG, Zillikens MC et al. Low dietary riboflavin but not folate predicts increased fracture risk in postmenopausal women homozygous for the MTHFR 677 T allele. J Bone Miner Res 2008; 23 (1): 86–94.
16. Yazdanpanah N, Zillikens M, Rivadeneira F et al. Effect of dietary B vitamins on BMD and risk of fracture in elderly men and women: the Rotterdam study. Bone 2007; 41 (6): 987–94.
17. Persicov АV, Brodsky B. Unstable molecules form stable tissues. Proc Natl Acad Sci USA 2002; 99 (3): 1101–3.
18. Методические рекомендации МР 2.3.1.24.32-08 «Нормы физиологических потребностей в пищевых веществах и энергии для различных групп населения Российской Федерации». М., 2008. / Metodicheskie rekomendatsii MR 2.3.1.24.32-08 «Normy fiziologicheskikh potrebnostei v pishchevykh veshchestvakh i energii dlia razlichnykh grupp naseleniia Rossiiskoi Federatsii». M., 2008. [in Russian]
19. Cashman KD. Calcium intake, calcium bioavailability and bone health. Br J Nutr 2002; 87 (2): 169–77.
20. ICSI Health Care Guideline: Diagnosis and treatment of osteoporosis. 2003.
21. Kanis JA., Johansson H, Oden A et al. A Meta-analysis of milk intake and fracture risk. J Bone Miner Res 2004; 356.
22. Lappe JM, Rafferty KA, Davies KM, Lypaczewski G. Girls on a high-calcium diet gain weight at the same rate as girl on a normal diet: a pilot study. J Am Diet Assoc 2004; 104 (9): 1985–96.
23. Ma J, Johns RA, Stafford RS. Americans are not meeting current calcium recommendations. Am J Clin Nutr 2007; 85 (5): 1361–6.
24. Heaney RP, Nordin BE. Calcium effects on phosphorus absorption: implications for the prevention and co-therapy of osteoporosis. J Am Coll Nutr 2002; 21: 239–44.
25. Shapiro R, Heaney RP. Co-dependence of calcium and phosphorus for growth and bone development under conditions of varying deficiency. Bone 2003; 32: 532–40.
26. De Francisco AL, Rodriguez M. Magnesium – its role in CKD. Nefrologia 2013; 33 (3): 389–99.
27. Торшин И.Ю., Громова О.А. Молекулярные механизмы дефицита магния в недифференцированной дисплазии соединительной ткани. Рос. мед. журн. 2008; 2: 62–7. / Torshin I.Iu., Gromova O.A. Molekuliarnye mekhanizmy defitsita magniia v nedifferentsirovannoi displazii soedinitel'noi tkani. Ros. med. zhurn. 2008; 2: 62–7. [in Russian]
28. Swaminathan R. Nutritional factors in osteoporosis. Int J Clin Pract 1999; 53 (7): 540.
29. Ryder KM, Shorr RI, Bush AJ et al. Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects. J Am Geriatr Soc 2005; 53: 1875–80.
30. Jones G, Riley MD, Dwyer T. Maternal diet during pregnancy is associated with bone mineral density in children: a longitudinal study. Eur J Clin Nutr 2000; 54 (10): 749–56.
31. Керимкулова Н.В., Торшин И.Ю., Громова О.А. и др. Систематический анализ молекулярно-физиологических эффектов синергидного воздействия железа, марганца и меди на соединительную ткань. Гинекология. 2012; 6: 51–60. / Kerimkulova N.V., Torshin I.Yu., Gromova O.A. et al. Systematic analysis of molecular and physiological synergic effects of iron, manganese and copper on connective tissue. Ginekology. 2012; 6: 51–60. [in Russian]
32. Opsahl W, Zeronian H, Ellison M et al. Role of copper in collagen cross-linking and its influence on selected mechanical properties of chick bone and tendon. J Nutr 1982; 112 (4): 708–16.
33. Mutlu M, Argun M, Kilic E et al. Magnesium, zinc and copper status in osteoporotic, osteopenic and normal postmenopausal women. J Int Med Res 2007; 35 (5): 692–5.
34. Odabasi E, Turan M, Aydin A et al. Magnesium, zinc, copper, manganese, and selenium levels in postmenopausal women with osteoporosis. Can magnesium play a key role in osteoporosis? Ann Acad Med Singapore 2008; 37 (7): 564–7.
35. Lowe NM, Fraser WD, Jackson MJ. Is there a potential therapeutic value of copper and zinc for osteoporosis? Proc Nutr Soc 2002; 61 (2): 181–5.
36. Gur A, Colpan L, Nas K et al. The role of trace minerals in the pathogenesis of postmenopausal osteoporosis and new effect of calcitonin. J Bone Miner Metab 2002; 20: 39–43.
37. Hill T, Meunier N, Andriollo-Sanchez M et al. The relationship between the zinc nutritive status and biochemical markers of bone turnover in older European adults: the ZENITH study. Eur J Clin Nutr 2005; 59 (Suppl. 2): S73–S78.
38. Ребров В.Г., Громова О.А. Витамины, макро- и микроэлементы. М.: ГЭОТАР-МЕД, 2008. / Rebrov V.G., Gromova O.A. Vitaminy, makro- i mikroelementy. M.: GEOTAR-MED, 2008. [in Russian]
39. Liao SF, Monegue JS, Lindemann MD et al. Dietarysupplementation of boron differentially alters expression of borate transporter (NaBCl) mRNA by jejunum and kidney of growing pigs. Biol Trace Elem Res 2011; 143 (2): 901–12.
40. Tasli PN, Dogan A, Demirci S, Sahin F. Boron enhances odontogenic and osteogenic differentiation of human tooth germ stem cells (hTGSCs) in vitro. Biol Trace Elem Res 2013; 153 (1–3): 419–27.
41. Ying X, Cheng S, Wang W et al. Effect of boron on osteogenic differentiation of human bone marrow stromal cells. Biol Trace Elem Res 2011; 144 (1–3): 306–15.
42. Hakki SS, Bozkurt BS, Hakki EE. Boron regulates mineralized tissue-associated proteins in osteoblasts (MC3 T3-E1). J Trace Elem Med Biol 2010; 24 (4): 243–50
43. Naghii MR, Torkaman G, Mofid M. Effects of boron and calcium supplementation on mechanical properties of bone in rats. Biofactors 2006; 28 (3–4): 195–201.
44. Gorustovich AA, Steimetz T, Nielsen FH, Guglielmotti MB. A histomorphometric study of alveolar bone modelling and remodelling in mice fed a boron-deficient diet. Arch Oral Biol 2008; 53 (7): 677–82.
45. Gorustovich AA, Steimetz T, Nielsen FH, Guglielmotti MB. Histomorphometric study of alveolar bone healing in rats fed a boron-deficient diet. Anat Rec (Hoboken) 2008; 291 (4): 441–7.
46. Naghii MR, Ebrahimpour Y, Darvishi P et al. Effect of consumption of fatty acids, calcium, vitamin D and boron with regular physical activity on bone mechanical properties and corresponding metabolic hormones in rats. Indian J Exp Biol 2012; 50 (3): 223–31.
47. Hakki SS, Dundar N, Kayis SA et al. Boron enhances strength and alters mineral composition of bone in rabbits fed a high energy diet. J Trace Elem Med Biol 2013; 27 (2): 148–53.
48. Ghanizadeh G, Babaei M, Naghii MR et al. The effect of supplementation of calcium, vitamin D, boron, and increased fluoride intake on bone mechanical properties and metabolic hormones in rat. Toxicol Ind Health 2014; 30 (3): 211–7.
49. Клинические рекомендации. Остеопороз: диагностика, профилактика и лечение. Под ред. Л.И.Беневоленской, О.М.Лесняк. М.: ГЭОТАР-Медиа, 2009. / Klinicheskie rekomendatsii. Osteoporoz: diagnostika, profilaktika i lechenie. Pod red. L.I.Benevolenskoi, O.M.Lesniak. M.: GEOTAR-Media, 2009. [in Russian]
50. Захарова И.Н., Творогова Т.М., Воробьева А.С., Кузнецова О.А. Микроэлементоз как фактор формирования остеопении у подростков. Педиатрия. 2012; 91 (1): 67–75. / Zakharova I.N., Tvorogova T.M., Vorob'eva A.S., Kuznetsova O.A. Mikroelementoz kak faktor formirovaniia osteopenii u podrostkov. Pediatriia. 2012; 91 (1): 67–75. [in Russian]
51. Никитинская О.А., Торопцова Н.В., Беневоленская О.А. Фармакологическая профилактика первичного остеопороза. РМЖ. 2008; 16 (6): 409–13. / Nikitinskaia O.A., Toroptsova N.V., Benevolenskaia O.A. Farmakologicheskaia profilaktika pervichnogo osteoporoza. RMZh. 2008; 16 (6): 409–13. [in Russian]
52. Демидов В.И., Жидоморов Н.Ю., Громова О.А и др. Роль кальция, витамина D3 и остеотропных минералов в профилактике и комплексном лечении перелома берцовой кости: результаты рандомизированного плацебо-контролируемого эксперимента. Лечащий врач. 2014; 12: 1–6. / Demidov V.I., Zhidomorov N.Iu., Gromova O.A i dr. Rol' kal'tsiia, vitamina D3 i osteotropnykh mineralov v profilaktike i kompleksnom lechenii pereloma bertsovoi kosti: rezul'taty randomizirovannogo platsebo-kontroliruemogo eksperimenta. Lechashchii vrach. 2014; 12: 1–6. [in Russian]
2. Benevolenskaia L.I., Nikitinskaia O.A., Toroptsova N.V. Farmakologicheskaia profilaktika pervichnogo osteoporoza. RMZh. 2008; 16 (6): 409–14. [in Russian]
3. Ogloblin N.A., Vrzhesinskaia O.A., Kodentsova V.M. i dr. Obespechennost' bol'nykh, stradaiushchikh serdechno-sosudistymi zabolevaniiami, vitaminami i mineral'nymi veshchestvami. Vopr. pitaniia. 2007; 76 (1): 31–8. [in Russian]
4. Ogloblin N.A., Spirichev V.B., Baturin A.K. O potreblenii naseleniem Rossii kal'tsiia s pishchei. Vopr. pitaniia. 2005; 5: 14–7. [in Russian]
5. Svetikova A.A., Kodentsova V.M., Vrzhesinskaia O.A. i dr. Osobennosti mineralizatsii kostnoi tkani u bol'nykh s serdechno-sosudistoi i zheludochno-kishechnoi patologiei i obespechennost' ikh vitaminami i kal'tsiem. Vopr. pitaniia. 2008; 1: 20–25. [in Russian]
6. Svetikova A.A., Vrzhesinskaia O.A., Kodentsova V.M. i dr. Vitaminnyi status i mineral'naia plotnost' kostnoi tkani u bol'nykh s ozhireniem i serdechno-sosudistoi patologiei. Vopr. pitaniia. 2008; 3: 39–44. [in Russian]
7. Baldini V, Mastropasqua M, Francucci CM, D'Erasmo E. Cardiovascular disease and osteoporosis. J Endocrinol Invest 2005; 28 (10): 69–72.
8. Bolton-Smith С, McMurdo М, Paterson СR et al. Two-Year Randomized Controlled Trial of Vitamin K1 (Phylloquinone) and Vitamin D3 Plus Calcium on the Bone Health of Older Women. J Bone Miner Res 2007; 22: 509–19.
9. Gnudi S, Sitta E, Fiumi N. Relationship between body composition and bone mineral density in women with and without osteoporosis: relative contribution of lean and fat mass. J Bone Miner Metab 2007; 25 (5): 326–32.
10. Jurutka PW, Bartik L, Whitfield GK et al. Vitamin D receptor: key roles in bone mineral pathophysiology, molecular mechanism of action, and novel nutritional ligands. J Bone Miner Res 2007; 22 (2): 2–10.
11. Mitra S, Desai M, Ikram Khatkhatay M. Vitamin D receptor gene polymorphisms and bone mineral den-sity in postmenopausal Indian women. Maturitas 2006; 55 (1): 27–35.
12. Rejnmark L, Lauridsen A, Vestergaard P et al. Vitamin D Status: long-term variability in postmenopausal women. A Follow Up Study. J Bone Miner Res 2004; 578.
13. Ribaya-Mercado JD, Blumberg GB. Vitamin A: is it a risk factor for osteoporosis and bone fracture? Nutr Rev 2007; 65 (10): 425–38.
14. Villadsen MM, Bunger MH, Carstens M et al. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with osteoporotic vertebral fractures, but is a weak predictor of BMD. Osteoporos Int 2005; 16 (4): 411–6.
15. Yazdanpanah N, Uitterlinden AG, Zillikens MC et al. Low dietary riboflavin but not folate predicts increased fracture risk in postmenopausal women homozygous for the MTHFR 677 T allele. J Bone Miner Res 2008; 23 (1): 86–94.
16. Yazdanpanah N, Zillikens M, Rivadeneira F et al. Effect of dietary B vitamins on BMD and risk of fracture in elderly men and women: the Rotterdam study. Bone 2007; 41 (6): 987–94.
17. Persicov АV, Brodsky B. Unstable molecules form stable tissues. Proc Natl Acad Sci USA 2002; 99 (3): 1101–3.
18. Metodicheskie rekomendatsii MR 2.3.1.24.32-08 «Normy fiziologicheskikh potrebnostei v pishchevykh veshchestvakh i energii dlia razlichnykh grupp naseleniia Rossiiskoi Federatsii». M., 2008. [in Russian]
19. Cashman KD. Calcium intake, calcium bioavailability and bone health. Br J Nutr 2002; 87 (2): 169–77.
20. ICSI Health Care Guideline: Diagnosis and treatment of osteoporosis. 2003.
21. Kanis JA., Johansson H, Oden A et al. A Meta-analysis of milk intake and fracture risk. J Bone Miner Res 2004; 356.
22. Lappe JM, Rafferty KA, Davies KM, Lypaczewski G. Girls on a high-calcium diet gain weight at the same rate as girl on a normal diet: a pilot study. J Am Diet Assoc 2004; 104 (9): 1985–96.
23. Ma J, Johns RA, Stafford RS. Americans are not meeting current calcium recommendations. Am J Clin Nutr 2007; 85 (5): 1361–6.
24. Heaney RP, Nordin BE. Calcium effects on phosphorus absorption: implications for the prevention and co-therapy of osteoporosis. J Am Coll Nutr 2002; 21: 239–44.
25. Shapiro R, Heaney RP. Co-dependence of calcium and phosphorus for growth and bone development under conditions of varying deficiency. Bone 2003; 32: 532–40.
26. De Francisco AL, Rodriguez M. Magnesium – its role in CKD. Nefrologia 2013; 33 (3): 389–99.
27. Torshin I.Iu., Gromova O.A. Molekuliarnye mekhanizmy defitsita magniia v nedifferentsirovannoi displazii soedinitel'noi tkani. Ros. med. zhurn. 2008; 2: 62–7. [in Russian]
28. Swaminathan R. Nutritional factors in osteoporosis. Int J Clin Pract 1999; 53 (7): 540.
29. Ryder KM, Shorr RI, Bush AJ et al. Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects. J Am Geriatr Soc 2005; 53: 1875–80.
30. Jones G, Riley MD, Dwyer T. Maternal diet during pregnancy is associated with bone mineral density in children: a longitudinal study. Eur J Clin Nutr 2000; 54 (10): 749–56.
31. Kerimkulova N.V., Torshin I.Yu., Gromova O.A. et al. Systematic analysis of molecular and physiological synergic effects of iron, manganese and copper on connective tissue. Ginekology. 2012; 6: 51–60. [in Russian]
32. Opsahl W, Zeronian H, Ellison M et al. Role of copper in collagen cross-linking and its influence on selected mechanical properties of chick bone and tendon. J Nutr 1982; 112 (4): 708–16.
33. Mutlu M, Argun M, Kilic E et al. Magnesium, zinc and copper status in osteoporotic, osteopenic and normal postmenopausal women. J Int Med Res 2007; 35 (5): 692–5.
34. Odabasi E, Turan M, Aydin A et al. Magnesium, zinc, copper, manganese, and selenium levels in postmenopausal women with osteoporosis. Can magnesium play a key role in osteoporosis? Ann Acad Med Singapore 2008; 37 (7): 564–7.
35. Lowe NM, Fraser WD, Jackson MJ. Is there a potential therapeutic value of copper and zinc for osteoporosis? Proc Nutr Soc 2002; 61 (2): 181–5.
36. Gur A, Colpan L, Nas K et al. The role of trace minerals in the pathogenesis of postmenopausal osteoporosis and new effect of calcitonin. J Bone Miner Metab 2002; 20: 39–43.
37. Hill T, Meunier N, Andriollo-Sanchez M et al. The relationship between the zinc nutritive status and biochemical markers of bone turnover in older European adults: the ZENITH study. Eur J Clin Nutr 2005; 59 (Suppl. 2): S73–S78.
38. Rebrov V.G., Gromova O.A. Vitaminy, makro- i mikroelementy. M.: GEOTAR-MED, 2008. [in Russian]
39. Liao SF, Monegue JS, Lindemann MD et al. Dietarysupplementation of boron differentially alters expression of borate transporter (NaBCl) mRNA by jejunum and kidney of growing pigs. Biol Trace Elem Res 2011; 143 (2): 901–12.
40. Tasli PN, Dogan A, Demirci S, Sahin F. Boron enhances odontogenic and osteogenic differentiation of human tooth germ stem cells (hTGSCs) in vitro. Biol Trace Elem Res 2013; 153 (1–3): 419–27.
41. Ying X, Cheng S, Wang W et al. Effect of boron on osteogenic differentiation of human bone marrow stromal cells. Biol Trace Elem Res 2011; 144 (1–3): 306–15.
42. Hakki SS, Bozkurt BS, Hakki EE. Boron regulates mineralized tissue-associated proteins in osteoblasts (MC3 T3-E1). J Trace Elem Med Biol 2010; 24 (4): 243–50
43. Naghii MR, Torkaman G, Mofid M. Effects of boron and calcium supplementation on mechanical properties of bone in rats. Biofactors 2006; 28 (3–4): 195–201.
44. Gorustovich AA, Steimetz T, Nielsen FH, Guglielmotti MB. A histomorphometric study of alveolar bone modelling and remodelling in mice fed a boron-deficient diet. Arch Oral Biol 2008; 53 (7): 677–82.
45. Gorustovich AA, Steimetz T, Nielsen FH, Guglielmotti MB. Histomorphometric study of alveolar bone healing in rats fed a boron-deficient diet. Anat Rec (Hoboken) 2008; 291 (4): 441–7.
46. Naghii MR, Ebrahimpour Y, Darvishi P et al. Effect of consumption of fatty acids, calcium, vitamin D and boron with regular physical activity on bone mechanical properties and corresponding metabolic hormones in rats. Indian J Exp Biol 2012; 50 (3): 223–31.
47. Hakki SS, Dundar N, Kayis SA et al. Boron enhances strength and alters mineral composition of bone in rabbits fed a high energy diet. J Trace Elem Med Biol 2013; 27 (2): 148–53.
48. Ghanizadeh G, Babaei M, Naghii MR et al. The effect of supplementation of calcium, vitamin D, boron, and increased fluoride intake on bone mechanical properties and metabolic hormones in rat. Toxicol Ind Health 2014; 30 (3): 211–7.
49. Klinicheskie rekomendatsii. Osteoporoz: diagnostika, profilaktika i lechenie. Pod red. L.I.Benevolenskoi, O.M.Lesniak. M.: GEOTAR-Media, 2009. [in Russian]
50. Zakharova I.N., Tvorogova T.M., Vorob'eva A.S., Kuznetsova O.A. Mikroelementoz kak faktor formirovaniia osteopenii u podrostkov. Pediatriia. 2012; 91 (1): 67–75. [in Russian]
51. Nikitinskaia O.A., Toroptsova N.V., Benevolenskaia O.A. Farmakologicheskaia profilaktika pervichnogo osteoporoza. RMZh. 2008; 16 (6): 409–13. [in Russian]
52. Demidov V.I., Zhidomorov N.Iu., Gromova O.A i dr. Rol' kal'tsiia, vitamina D3 i osteotropnykh mineralov v profilaktike i kompleksnom lechenii pereloma bertsovoi kosti: rezul'taty randomizirovannogo platsebo-kontroliruemogo eksperimenta. Lechashchii vrach. 2014; 12: 1–6. [in Russian]
2. Беневоленская Л.И., Никитинская О.А., Торопцова Н.В. Фармакологическая профилактика первичного остеопороза. РМЖ. 2008; 16 (6): 409–14. / Benevolenskaia L.I., Nikitinskaia O.A., Toroptsova N.V. Farmakologicheskaia profilaktika pervichnogo osteoporoza. RMZh. 2008; 16 (6): 409–14. [in Russian]
3. Оглоблин Н.А., Вржесинская О.А., Коденцова В.М. и др. Обеспеченность больных, страдающих сердечно-сосудистыми заболеваниями, витаминами и минеральными веществами. Вопр. питания. 2007; 76 (1): 31–8. / Ogloblin N.A., Vrzhesinskaia O.A., Kodentsova V.M. i dr. Obespechennost' bol'nykh, stradaiushchikh serdechno-sosudistymi zabolevaniiami, vitaminami i mineral'nymi veshchestvami. Vopr. pitaniia. 2007; 76 (1): 31–8. [in Russian]
4. Оглоблин Н.А., Спиричев В.Б., Батурин А.К. О потреблении населением России кальция с пищей. Вопр. питания. 2005; 5: 14–7. / Ogloblin N.A., Spirichev V.B., Baturin A.K. O potreblenii naseleniem Rossii kal'tsiia s pishchei. Vopr. pitaniia. 2005; 5: 14–7. [in Russian]
5. Светикова А.А., Коденцова В.М., Вржесинская О.А. и др. Особенности минерализации костной ткани у больных с сердечно-сосудистой и желудочно-кишечной патологией и обеспеченность их витаминами и кальцием. Вопр. питания. 2008; 1: 20–25. / Svetikova A.A., Kodentsova V.M., Vrzhesinskaia O.A. i dr. Osobennosti mineralizatsii kostnoi tkani u bol'nykh s serdechno-sosudistoi i zheludochno-kishechnoi patologiei i obespechennost' ikh vitaminami i kal'tsiem. Vopr. pitaniia. 2008; 1: 20–25. [in Russian]
6. Светикова А.А., Вржесинская О.А., Коденцова В.М. и др. Витаминный статус и минеральная плотность костной ткани у больных с ожирением и сердечно-сосудистой патологией. Вопр. питания. 2008; 3: 39–44. / Svetikova A.A., Vrzhesinskaia O.A., Kodentsova V.M. i dr. Vitaminnyi status i mineral'naia plotnost' kostnoi tkani u bol'nykh s ozhireniem i serdechno-sosudistoi patologiei. Vopr. pitaniia. 2008; 3: 39–44. [in Russian]
7. Baldini V, Mastropasqua M, Francucci CM, D'Erasmo E. Cardiovascular disease and osteoporosis. J Endocrinol Invest 2005; 28 (10): 69–72.
8. Bolton-Smith С, McMurdo М, Paterson СR et al. Two-Year Randomized Controlled Trial of Vitamin K1 (Phylloquinone) and Vitamin D3 Plus Calcium on the Bone Health of Older Women. J Bone Miner Res 2007; 22: 509–19.
9. Gnudi S, Sitta E, Fiumi N. Relationship between body composition and bone mineral density in women with and without osteoporosis: relative contribution of lean and fat mass. J Bone Miner Metab 2007; 25 (5): 326–32.
10. Jurutka PW, Bartik L, Whitfield GK et al. Vitamin D receptor: key roles in bone mineral pathophysiology, molecular mechanism of action, and novel nutritional ligands. J Bone Miner Res 2007; 22 (2): 2–10.
11. Mitra S, Desai M, Ikram Khatkhatay M. Vitamin D receptor gene polymorphisms and bone mineral den-sity in postmenopausal Indian women. Maturitas 2006; 55 (1): 27–35.
12. Rejnmark L, Lauridsen A, Vestergaard P et al. Vitamin D Status: long-term variability in postmenopausal women. A Follow Up Study. J Bone Miner Res 2004; 578.
13. Ribaya-Mercado JD, Blumberg GB. Vitamin A: is it a risk factor for osteoporosis and bone fracture? Nutr Rev 2007; 65 (10): 425–38.
14. Villadsen MM, Bunger MH, Carstens M et al. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with osteoporotic vertebral fractures, but is a weak predictor of BMD. Osteoporos Int 2005; 16 (4): 411–6.
15. Yazdanpanah N, Uitterlinden AG, Zillikens MC et al. Low dietary riboflavin but not folate predicts increased fracture risk in postmenopausal women homozygous for the MTHFR 677 T allele. J Bone Miner Res 2008; 23 (1): 86–94.
16. Yazdanpanah N, Zillikens M, Rivadeneira F et al. Effect of dietary B vitamins on BMD and risk of fracture in elderly men and women: the Rotterdam study. Bone 2007; 41 (6): 987–94.
17. Persicov АV, Brodsky B. Unstable molecules form stable tissues. Proc Natl Acad Sci USA 2002; 99 (3): 1101–3.
18. Методические рекомендации МР 2.3.1.24.32-08 «Нормы физиологических потребностей в пищевых веществах и энергии для различных групп населения Российской Федерации». М., 2008. / Metodicheskie rekomendatsii MR 2.3.1.24.32-08 «Normy fiziologicheskikh potrebnostei v pishchevykh veshchestvakh i energii dlia razlichnykh grupp naseleniia Rossiiskoi Federatsii». M., 2008. [in Russian]
19. Cashman KD. Calcium intake, calcium bioavailability and bone health. Br J Nutr 2002; 87 (2): 169–77.
20. ICSI Health Care Guideline: Diagnosis and treatment of osteoporosis. 2003.
21. Kanis JA., Johansson H, Oden A et al. A Meta-analysis of milk intake and fracture risk. J Bone Miner Res 2004; 356.
22. Lappe JM, Rafferty KA, Davies KM, Lypaczewski G. Girls on a high-calcium diet gain weight at the same rate as girl on a normal diet: a pilot study. J Am Diet Assoc 2004; 104 (9): 1985–96.
23. Ma J, Johns RA, Stafford RS. Americans are not meeting current calcium recommendations. Am J Clin Nutr 2007; 85 (5): 1361–6.
24. Heaney RP, Nordin BE. Calcium effects on phosphorus absorption: implications for the prevention and co-therapy of osteoporosis. J Am Coll Nutr 2002; 21: 239–44.
25. Shapiro R, Heaney RP. Co-dependence of calcium and phosphorus for growth and bone development under conditions of varying deficiency. Bone 2003; 32: 532–40.
26. De Francisco AL, Rodriguez M. Magnesium – its role in CKD. Nefrologia 2013; 33 (3): 389–99.
27. Торшин И.Ю., Громова О.А. Молекулярные механизмы дефицита магния в недифференцированной дисплазии соединительной ткани. Рос. мед. журн. 2008; 2: 62–7. / Torshin I.Iu., Gromova O.A. Molekuliarnye mekhanizmy defitsita magniia v nedifferentsirovannoi displazii soedinitel'noi tkani. Ros. med. zhurn. 2008; 2: 62–7. [in Russian]
28. Swaminathan R. Nutritional factors in osteoporosis. Int J Clin Pract 1999; 53 (7): 540.
29. Ryder KM, Shorr RI, Bush AJ et al. Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects. J Am Geriatr Soc 2005; 53: 1875–80.
30. Jones G, Riley MD, Dwyer T. Maternal diet during pregnancy is associated with bone mineral density in children: a longitudinal study. Eur J Clin Nutr 2000; 54 (10): 749–56.
31. Керимкулова Н.В., Торшин И.Ю., Громова О.А. и др. Систематический анализ молекулярно-физиологических эффектов синергидного воздействия железа, марганца и меди на соединительную ткань. Гинекология. 2012; 6: 51–60. / Kerimkulova N.V., Torshin I.Yu., Gromova O.A. et al. Systematic analysis of molecular and physiological synergic effects of iron, manganese and copper on connective tissue. Ginekology. 2012; 6: 51–60. [in Russian]
32. Opsahl W, Zeronian H, Ellison M et al. Role of copper in collagen cross-linking and its influence on selected mechanical properties of chick bone and tendon. J Nutr 1982; 112 (4): 708–16.
33. Mutlu M, Argun M, Kilic E et al. Magnesium, zinc and copper status in osteoporotic, osteopenic and normal postmenopausal women. J Int Med Res 2007; 35 (5): 692–5.
34. Odabasi E, Turan M, Aydin A et al. Magnesium, zinc, copper, manganese, and selenium levels in postmenopausal women with osteoporosis. Can magnesium play a key role in osteoporosis? Ann Acad Med Singapore 2008; 37 (7): 564–7.
35. Lowe NM, Fraser WD, Jackson MJ. Is there a potential therapeutic value of copper and zinc for osteoporosis? Proc Nutr Soc 2002; 61 (2): 181–5.
36. Gur A, Colpan L, Nas K et al. The role of trace minerals in the pathogenesis of postmenopausal osteoporosis and new effect of calcitonin. J Bone Miner Metab 2002; 20: 39–43.
37. Hill T, Meunier N, Andriollo-Sanchez M et al. The relationship between the zinc nutritive status and biochemical markers of bone turnover in older European adults: the ZENITH study. Eur J Clin Nutr 2005; 59 (Suppl. 2): S73–S78.
38. Ребров В.Г., Громова О.А. Витамины, макро- и микроэлементы. М.: ГЭОТАР-МЕД, 2008. / Rebrov V.G., Gromova O.A. Vitaminy, makro- i mikroelementy. M.: GEOTAR-MED, 2008. [in Russian]
39. Liao SF, Monegue JS, Lindemann MD et al. Dietarysupplementation of boron differentially alters expression of borate transporter (NaBCl) mRNA by jejunum and kidney of growing pigs. Biol Trace Elem Res 2011; 143 (2): 901–12.
40. Tasli PN, Dogan A, Demirci S, Sahin F. Boron enhances odontogenic and osteogenic differentiation of human tooth germ stem cells (hTGSCs) in vitro. Biol Trace Elem Res 2013; 153 (1–3): 419–27.
41. Ying X, Cheng S, Wang W et al. Effect of boron on osteogenic differentiation of human bone marrow stromal cells. Biol Trace Elem Res 2011; 144 (1–3): 306–15.
42. Hakki SS, Bozkurt BS, Hakki EE. Boron regulates mineralized tissue-associated proteins in osteoblasts (MC3 T3-E1). J Trace Elem Med Biol 2010; 24 (4): 243–50
43. Naghii MR, Torkaman G, Mofid M. Effects of boron and calcium supplementation on mechanical properties of bone in rats. Biofactors 2006; 28 (3–4): 195–201.
44. Gorustovich AA, Steimetz T, Nielsen FH, Guglielmotti MB. A histomorphometric study of alveolar bone modelling and remodelling in mice fed a boron-deficient diet. Arch Oral Biol 2008; 53 (7): 677–82.
45. Gorustovich AA, Steimetz T, Nielsen FH, Guglielmotti MB. Histomorphometric study of alveolar bone healing in rats fed a boron-deficient diet. Anat Rec (Hoboken) 2008; 291 (4): 441–7.
46. Naghii MR, Ebrahimpour Y, Darvishi P et al. Effect of consumption of fatty acids, calcium, vitamin D and boron with regular physical activity on bone mechanical properties and corresponding metabolic hormones in rats. Indian J Exp Biol 2012; 50 (3): 223–31.
47. Hakki SS, Dundar N, Kayis SA et al. Boron enhances strength and alters mineral composition of bone in rabbits fed a high energy diet. J Trace Elem Med Biol 2013; 27 (2): 148–53.
48. Ghanizadeh G, Babaei M, Naghii MR et al. The effect of supplementation of calcium, vitamin D, boron, and increased fluoride intake on bone mechanical properties and metabolic hormones in rat. Toxicol Ind Health 2014; 30 (3): 211–7.
49. Клинические рекомендации. Остеопороз: диагностика, профилактика и лечение. Под ред. Л.И.Беневоленской, О.М.Лесняк. М.: ГЭОТАР-Медиа, 2009. / Klinicheskie rekomendatsii. Osteoporoz: diagnostika, profilaktika i lechenie. Pod red. L.I.Benevolenskoi, O.M.Lesniak. M.: GEOTAR-Media, 2009. [in Russian]
50. Захарова И.Н., Творогова Т.М., Воробьева А.С., Кузнецова О.А. Микроэлементоз как фактор формирования остеопении у подростков. Педиатрия. 2012; 91 (1): 67–75. / Zakharova I.N., Tvorogova T.M., Vorob'eva A.S., Kuznetsova O.A. Mikroelementoz kak faktor formirovaniia osteopenii u podrostkov. Pediatriia. 2012; 91 (1): 67–75. [in Russian]
51. Никитинская О.А., Торопцова Н.В., Беневоленская О.А. Фармакологическая профилактика первичного остеопороза. РМЖ. 2008; 16 (6): 409–13. / Nikitinskaia O.A., Toroptsova N.V., Benevolenskaia O.A. Farmakologicheskaia profilaktika pervichnogo osteoporoza. RMZh. 2008; 16 (6): 409–13. [in Russian]
52. Демидов В.И., Жидоморов Н.Ю., Громова О.А и др. Роль кальция, витамина D3 и остеотропных минералов в профилактике и комплексном лечении перелома берцовой кости: результаты рандомизированного плацебо-контролируемого эксперимента. Лечащий врач. 2014; 12: 1–6. / Demidov V.I., Zhidomorov N.Iu., Gromova O.A i dr. Rol' kal'tsiia, vitamina D3 i osteotropnykh mineralov v profilaktike i kompleksnom lechenii pereloma bertsovoi kosti: rezul'taty randomizirovannogo platsebo-kontroliruemogo eksperimenta. Lechashchii vrach. 2014; 12: 1–6. [in Russian]
________________________________________________
2. Benevolenskaia L.I., Nikitinskaia O.A., Toroptsova N.V. Farmakologicheskaia profilaktika pervichnogo osteoporoza. RMZh. 2008; 16 (6): 409–14. [in Russian]
3. Ogloblin N.A., Vrzhesinskaia O.A., Kodentsova V.M. i dr. Obespechennost' bol'nykh, stradaiushchikh serdechno-sosudistymi zabolevaniiami, vitaminami i mineral'nymi veshchestvami. Vopr. pitaniia. 2007; 76 (1): 31–8. [in Russian]
4. Ogloblin N.A., Spirichev V.B., Baturin A.K. O potreblenii naseleniem Rossii kal'tsiia s pishchei. Vopr. pitaniia. 2005; 5: 14–7. [in Russian]
5. Svetikova A.A., Kodentsova V.M., Vrzhesinskaia O.A. i dr. Osobennosti mineralizatsii kostnoi tkani u bol'nykh s serdechno-sosudistoi i zheludochno-kishechnoi patologiei i obespechennost' ikh vitaminami i kal'tsiem. Vopr. pitaniia. 2008; 1: 20–25. [in Russian]
6. Svetikova A.A., Vrzhesinskaia O.A., Kodentsova V.M. i dr. Vitaminnyi status i mineral'naia plotnost' kostnoi tkani u bol'nykh s ozhireniem i serdechno-sosudistoi patologiei. Vopr. pitaniia. 2008; 3: 39–44. [in Russian]
7. Baldini V, Mastropasqua M, Francucci CM, D'Erasmo E. Cardiovascular disease and osteoporosis. J Endocrinol Invest 2005; 28 (10): 69–72.
8. Bolton-Smith С, McMurdo М, Paterson СR et al. Two-Year Randomized Controlled Trial of Vitamin K1 (Phylloquinone) and Vitamin D3 Plus Calcium on the Bone Health of Older Women. J Bone Miner Res 2007; 22: 509–19.
9. Gnudi S, Sitta E, Fiumi N. Relationship between body composition and bone mineral density in women with and without osteoporosis: relative contribution of lean and fat mass. J Bone Miner Metab 2007; 25 (5): 326–32.
10. Jurutka PW, Bartik L, Whitfield GK et al. Vitamin D receptor: key roles in bone mineral pathophysiology, molecular mechanism of action, and novel nutritional ligands. J Bone Miner Res 2007; 22 (2): 2–10.
11. Mitra S, Desai M, Ikram Khatkhatay M. Vitamin D receptor gene polymorphisms and bone mineral den-sity in postmenopausal Indian women. Maturitas 2006; 55 (1): 27–35.
12. Rejnmark L, Lauridsen A, Vestergaard P et al. Vitamin D Status: long-term variability in postmenopausal women. A Follow Up Study. J Bone Miner Res 2004; 578.
13. Ribaya-Mercado JD, Blumberg GB. Vitamin A: is it a risk factor for osteoporosis and bone fracture? Nutr Rev 2007; 65 (10): 425–38.
14. Villadsen MM, Bunger MH, Carstens M et al. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with osteoporotic vertebral fractures, but is a weak predictor of BMD. Osteoporos Int 2005; 16 (4): 411–6.
15. Yazdanpanah N, Uitterlinden AG, Zillikens MC et al. Low dietary riboflavin but not folate predicts increased fracture risk in postmenopausal women homozygous for the MTHFR 677 T allele. J Bone Miner Res 2008; 23 (1): 86–94.
16. Yazdanpanah N, Zillikens M, Rivadeneira F et al. Effect of dietary B vitamins on BMD and risk of fracture in elderly men and women: the Rotterdam study. Bone 2007; 41 (6): 987–94.
17. Persicov АV, Brodsky B. Unstable molecules form stable tissues. Proc Natl Acad Sci USA 2002; 99 (3): 1101–3.
18. Metodicheskie rekomendatsii MR 2.3.1.24.32-08 «Normy fiziologicheskikh potrebnostei v pishchevykh veshchestvakh i energii dlia razlichnykh grupp naseleniia Rossiiskoi Federatsii». M., 2008. [in Russian]
19. Cashman KD. Calcium intake, calcium bioavailability and bone health. Br J Nutr 2002; 87 (2): 169–77.
20. ICSI Health Care Guideline: Diagnosis and treatment of osteoporosis. 2003.
21. Kanis JA., Johansson H, Oden A et al. A Meta-analysis of milk intake and fracture risk. J Bone Miner Res 2004; 356.
22. Lappe JM, Rafferty KA, Davies KM, Lypaczewski G. Girls on a high-calcium diet gain weight at the same rate as girl on a normal diet: a pilot study. J Am Diet Assoc 2004; 104 (9): 1985–96.
23. Ma J, Johns RA, Stafford RS. Americans are not meeting current calcium recommendations. Am J Clin Nutr 2007; 85 (5): 1361–6.
24. Heaney RP, Nordin BE. Calcium effects on phosphorus absorption: implications for the prevention and co-therapy of osteoporosis. J Am Coll Nutr 2002; 21: 239–44.
25. Shapiro R, Heaney RP. Co-dependence of calcium and phosphorus for growth and bone development under conditions of varying deficiency. Bone 2003; 32: 532–40.
26. De Francisco AL, Rodriguez M. Magnesium – its role in CKD. Nefrologia 2013; 33 (3): 389–99.
27. Torshin I.Iu., Gromova O.A. Molekuliarnye mekhanizmy defitsita magniia v nedifferentsirovannoi displazii soedinitel'noi tkani. Ros. med. zhurn. 2008; 2: 62–7. [in Russian]
28. Swaminathan R. Nutritional factors in osteoporosis. Int J Clin Pract 1999; 53 (7): 540.
29. Ryder KM, Shorr RI, Bush AJ et al. Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects. J Am Geriatr Soc 2005; 53: 1875–80.
30. Jones G, Riley MD, Dwyer T. Maternal diet during pregnancy is associated with bone mineral density in children: a longitudinal study. Eur J Clin Nutr 2000; 54 (10): 749–56.
31. Kerimkulova N.V., Torshin I.Yu., Gromova O.A. et al. Systematic analysis of molecular and physiological synergic effects of iron, manganese and copper on connective tissue. Ginekology. 2012; 6: 51–60. [in Russian]
32. Opsahl W, Zeronian H, Ellison M et al. Role of copper in collagen cross-linking and its influence on selected mechanical properties of chick bone and tendon. J Nutr 1982; 112 (4): 708–16.
33. Mutlu M, Argun M, Kilic E et al. Magnesium, zinc and copper status in osteoporotic, osteopenic and normal postmenopausal women. J Int Med Res 2007; 35 (5): 692–5.
34. Odabasi E, Turan M, Aydin A et al. Magnesium, zinc, copper, manganese, and selenium levels in postmenopausal women with osteoporosis. Can magnesium play a key role in osteoporosis? Ann Acad Med Singapore 2008; 37 (7): 564–7.
35. Lowe NM, Fraser WD, Jackson MJ. Is there a potential therapeutic value of copper and zinc for osteoporosis? Proc Nutr Soc 2002; 61 (2): 181–5.
36. Gur A, Colpan L, Nas K et al. The role of trace minerals in the pathogenesis of postmenopausal osteoporosis and new effect of calcitonin. J Bone Miner Metab 2002; 20: 39–43.
37. Hill T, Meunier N, Andriollo-Sanchez M et al. The relationship between the zinc nutritive status and biochemical markers of bone turnover in older European adults: the ZENITH study. Eur J Clin Nutr 2005; 59 (Suppl. 2): S73–S78.
38. Rebrov V.G., Gromova O.A. Vitaminy, makro- i mikroelementy. M.: GEOTAR-MED, 2008. [in Russian]
39. Liao SF, Monegue JS, Lindemann MD et al. Dietarysupplementation of boron differentially alters expression of borate transporter (NaBCl) mRNA by jejunum and kidney of growing pigs. Biol Trace Elem Res 2011; 143 (2): 901–12.
40. Tasli PN, Dogan A, Demirci S, Sahin F. Boron enhances odontogenic and osteogenic differentiation of human tooth germ stem cells (hTGSCs) in vitro. Biol Trace Elem Res 2013; 153 (1–3): 419–27.
41. Ying X, Cheng S, Wang W et al. Effect of boron on osteogenic differentiation of human bone marrow stromal cells. Biol Trace Elem Res 2011; 144 (1–3): 306–15.
42. Hakki SS, Bozkurt BS, Hakki EE. Boron regulates mineralized tissue-associated proteins in osteoblasts (MC3 T3-E1). J Trace Elem Med Biol 2010; 24 (4): 243–50
43. Naghii MR, Torkaman G, Mofid M. Effects of boron and calcium supplementation on mechanical properties of bone in rats. Biofactors 2006; 28 (3–4): 195–201.
44. Gorustovich AA, Steimetz T, Nielsen FH, Guglielmotti MB. A histomorphometric study of alveolar bone modelling and remodelling in mice fed a boron-deficient diet. Arch Oral Biol 2008; 53 (7): 677–82.
45. Gorustovich AA, Steimetz T, Nielsen FH, Guglielmotti MB. Histomorphometric study of alveolar bone healing in rats fed a boron-deficient diet. Anat Rec (Hoboken) 2008; 291 (4): 441–7.
46. Naghii MR, Ebrahimpour Y, Darvishi P et al. Effect of consumption of fatty acids, calcium, vitamin D and boron with regular physical activity on bone mechanical properties and corresponding metabolic hormones in rats. Indian J Exp Biol 2012; 50 (3): 223–31.
47. Hakki SS, Dundar N, Kayis SA et al. Boron enhances strength and alters mineral composition of bone in rabbits fed a high energy diet. J Trace Elem Med Biol 2013; 27 (2): 148–53.
48. Ghanizadeh G, Babaei M, Naghii MR et al. The effect of supplementation of calcium, vitamin D, boron, and increased fluoride intake on bone mechanical properties and metabolic hormones in rat. Toxicol Ind Health 2014; 30 (3): 211–7.
49. Klinicheskie rekomendatsii. Osteoporoz: diagnostika, profilaktika i lechenie. Pod red. L.I.Benevolenskoi, O.M.Lesniak. M.: GEOTAR-Media, 2009. [in Russian]
50. Zakharova I.N., Tvorogova T.M., Vorob'eva A.S., Kuznetsova O.A. Mikroelementoz kak faktor formirovaniia osteopenii u podrostkov. Pediatriia. 2012; 91 (1): 67–75. [in Russian]
51. Nikitinskaia O.A., Toroptsova N.V., Benevolenskaia O.A. Farmakologicheskaia profilaktika pervichnogo osteoporoza. RMZh. 2008; 16 (6): 409–13. [in Russian]
52. Demidov V.I., Zhidomorov N.Iu., Gromova O.A i dr. Rol' kal'tsiia, vitamina D3 i osteotropnykh mineralov v profilaktike i kompleksnom lechenii pereloma bertsovoi kosti: rezul'taty randomizirovannogo platsebo-kontroliruemogo eksperimenta. Lechashchii vrach. 2014; 12: 1–6. [in Russian]
Авторы
А.В.Погожева
ФГБНУ НИИ питания. 109240, Россия, Москва, Устьинский проезд, д. 2/14
allapogozheva@yandex.ru
ФГБНУ НИИ питания. 109240, Россия, Москва, Устьинский проезд, д. 2/14
allapogozheva@yandex.ru
________________________________________________
A.V.Pogozheva
Institute of Nutrition. 109240, Russian Federation, Moscow, Ust'inskii proezd, d. 2/14
allapogozheva@yandex.ru
Institute of Nutrition. 109240, Russian Federation, Moscow, Ust'inskii proezd, d. 2/14
allapogozheva@yandex.ru
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