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Применение витаминов группы B в комплексном лечении диабетической нейропатии
Применение витаминов группы B в комплексном лечении диабетической нейропатии
Бирюкова Е.В., Ягубова Т.Р. Применение витаминов группы B в комплексном лечении диабетической нейропатии. Consilium Medicum. 2015; 17 (4): 68–72.
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Аннотация
Сахарный диабет является заболеванием, связанным с развитием разных осложнений. Диабетическая нейропатия – одно из наиболее тяжелых осложнений. Рассмотрены ключевые звенья патогенеза диабетической нейропатии. Подчеркивается значимость раннего выявления и лечения хронических осложнений сахарного диабета. Обсуждаются подходы к терапии диабетической нейропатии, включающие применение витаминов группы В.
Ключевые слова: сахарный диабет, хронические осложнения, диабетическая нейропатия, витамины группы В, Нейромультивит.
Key words: diabetes mellitus, chronic complications, diabetic neuropathy, vitamin B complex, Neuromultivit.
Ключевые слова: сахарный диабет, хронические осложнения, диабетическая нейропатия, витамины группы В, Нейромультивит.
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Key words: diabetes mellitus, chronic complications, diabetic neuropathy, vitamin B complex, Neuromultivit.
Полный текст
Список литературы
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3. Boulton AJM, Vinik AI, Arezzo JC et al. Diabetic neuropathy. A statement by the American Diabetes Association. Diabetes Care 2005b; 28: 956–62.
4. Brownlee M. The pathobiology of diabetic complications. A unifying mechanism. Diabetes 2005; 54: 1615–25.
5. DCCT: The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329: 977–86.
6. De Jager J, Kooy A, Lehert P. Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial. BMJ 2010; 340. Doi: http://dx.doi.org/10.1136/bmj.c2181.
7. Dejgaard A. Pathophysiology and treatment of diabetic neuropathy. Diabet Med 1998; 15: 97–112.
8. Happich M, John J, Stamenitis S et al. The quality of life and economic burden of neuropathy in diabetic patients in Germany in 2002 – results from the Diabetic Microvascular Complications (DIMICO) study. Diabetes Res Clin Pract 2008; 81: 223–30.
9. Harati Y. Diabetes and the nervous system. Endocrinol Metab Clin North Am 1996; 25 (2): 325–59.
10. Holman RR, Paul SK, Bethel MA et al. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 2008; 359: 1577–89.
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13. Mahajan R, Gupta K. Revisiting metformin: annual vitamin B12 supplementation may become mandatory with longterm metformin use. J Young Pharm 2010, 2: 428–9.
14. Marshall S, Flyvbjerg A. Prevention and early detection of vascular complications of diabetes. Brit Med J 2006; 333: 475–80.
15. McCandless DW. Thiamine Deficiency and Associated Clinical Disorders. Humana Press 2009.
16. Mooney S, Leuendorf J-E, Hendrickson C, Hellmann H. Vitamin B6: A Long Known Compound of Surprising Complexity Molecules 2009; 14: 329–51.
17. Pflipsen M, Oh R, Saguil A et al. The Prevalence of Vitamin B12 Deficiency in Patients with Type 2 Diabetes: a cross-sectional study. J Am Board Fam Med 2009; 22 (5): 528–34. Doi: 10.3122/jabfm.2009.05.090044. Erratum in: J Am Board Fam Med 2010; 23 (5): 695.
18. Reinstatler L, Qi YP, Williamson R, Garn JV et al. Association of Biochemical B12 Deficiency With Metformin Therapy and Vitamin B12 Supplements. Diabetes Care 2012; 35 (2): 327–33. Doi: 10.2337/dc11-1582.
19. Said G. Diabetic Neuropathy. A Review Nat Clin Pract Neurol 2007; 3 (6): 331–40.
20. Saito N, Kimura M, Kuchiba A, Itokawa Y. Blood thiamine levels in outpatients with diabetes mellitus. J Nutr Sci Vitaminol 1987; 33 (6): 421–31.
21. Shaw JE, Zimmet PZ. The epidemiology of diabetic neuropathy. Diabetes Reviews 1999; 7: 245–52.
22. Solomon LR. Disorders of cobalamin (vitamin B12) metabolism: emerging concept in patophysiology, diagnosis and treatment. Blood Rev 2007; 21: 113–30.
23. Stracke H, Lindemann A, Federlin K. A benfotiamine-vitamin B combination in the treatment of diabetic polyneuropathy. Exp Clin Endocrin Diabetes 1996; 104: 311–6.
24. Sun Y, Lai M, Lu C. Effectiveness of Vitamin B12 on Diabetic Neuropathy: Systematic Review of Clinical Controlled Trials. Acta Neurol Taiwan 2005, 14: 48–54.
25. Talaei A, Siavash M, Majidi H, Chehrei A. Vitamin B12 may be more effective than nortriptyline in improving painful diabetic neuropathy. Int J Food Sci Nutr 2009; 60: 71–6.
26. Thornalley PJ. The potential role of thiamine (vitamin B1) in diabetic complications. Curr Diabetes Rev 2005; 1: 287–98.
27. Thornalley PJ, Babaei-Jadidi R, Al Ali H et al. High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease. Diabetologia 2007; 50: 2164–70.
28. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complication in patients with type 2 diabetes. (UKPDS 33). Lancet 1998; 352: 837–53.
2. Boulton AJM, Vileikyte L, Ragnarson-Tennwall G, Apelqvist J. The global burden of diabetic foot disease. Lancet 2005a; 366: 1719–24.
3. Boulton AJM, Vinik AI, Arezzo JC et al. Diabetic neuropathy. A statement by the American Diabetes Association. Diabetes Care 2005b; 28: 956–62.
4. Brownlee M. The pathobiology of diabetic complications. A unifying mechanism. Diabetes 2005; 54: 1615–25.
5. DCCT: The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329: 977–86.
6. De Jager J, Kooy A, Lehert P. Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial. BMJ 2010; 340. Doi: http://dx.doi.org/10.1136/bmj.c2181.
7. Dejgaard A. Pathophysiology and treatment of diabetic neuropathy. Diabet Med 1998; 15: 97–112.
8. Happich M, John J, Stamenitis S et al. The quality of life and economic burden of neuropathy in diabetic patients in Germany in 2002 – results from the Diabetic Microvascular Complications (DIMICO) study. Diabetes Res Clin Pract 2008; 81: 223–30.
9. Harati Y. Diabetes and the nervous system. Endocrinol Metab Clin North Am 1996; 25 (2): 325–59.
10. Holman RR, Paul SK, Bethel MA et al. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 2008; 359: 1577–89.
11. Kempler P (ed). Neuropathies. Pathomechanism, clinical presentation, diagnosis, therapy. Budapest: Springer Scientific Publisher, 2002.
12. Kibirige D, Mwebaze R. Vitamin B12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified? J Diabetes Metab Disord 2013; 12. http://www.jdmdonline.com/content/12/1/17
13. Mahajan R, Gupta K. Revisiting metformin: annual vitamin B12 supplementation may become mandatory with longterm metformin use. J Young Pharm 2010, 2: 428–9.
14. Marshall S, Flyvbjerg A. Prevention and early detection of vascular complications of diabetes. Brit Med J 2006; 333: 475–80.
15. McCandless DW. Thiamine Deficiency and Associated Clinical Disorders. Humana Press 2009.
16. Mooney S, Leuendorf J-E, Hendrickson C, Hellmann H. Vitamin B6: A Long Known Compound of Surprising Complexity Molecules 2009; 14: 329–51.
17. Pflipsen M, Oh R, Saguil A et al. The Prevalence of Vitamin B12 Deficiency in Patients with Type 2 Diabetes: a cross-sectional study. J Am Board Fam Med 2009; 22 (5): 528–34. Doi: 10.3122/jabfm.2009.05.090044. Erratum in: J Am Board Fam Med 2010; 23 (5): 695.
18. Reinstatler L, Qi YP, Williamson R, Garn JV et al. Association of Biochemical B12 Deficiency With Metformin Therapy and Vitamin B12 Supplements. Diabetes Care 2012; 35 (2): 327–33. Doi: 10.2337/dc11-1582.
19. Said G. Diabetic Neuropathy. A Review Nat Clin Pract Neurol 2007; 3 (6): 331–40.
20. Saito N, Kimura M, Kuchiba A, Itokawa Y. Blood thiamine levels in outpatients with diabetes mellitus. J Nutr Sci Vitaminol 1987; 33 (6): 421–31.
21. Shaw JE, Zimmet PZ. The epidemiology of diabetic neuropathy. Diabetes Reviews 1999; 7: 245–52.
22. Solomon LR. Disorders of cobalamin (vitamin B12) metabolism: emerging concept in patophysiology, diagnosis and treatment. Blood Rev 2007; 21: 113–30.
23. Stracke H, Lindemann A, Federlin K. A benfotiamine-vitamin B combination in the treatment of diabetic polyneuropathy. Exp Clin Endocrin Diabetes 1996; 104: 311–6.
24. Sun Y, Lai M, Lu C. Effectiveness of Vitamin B12 on Diabetic Neuropathy: Systematic Review of Clinical Controlled Trials. Acta Neurol Taiwan 2005, 14: 48–54.
25. Talaei A, Siavash M, Majidi H, Chehrei A. Vitamin B12 may be more effective than nortriptyline in improving painful diabetic neuropathy. Int J Food Sci Nutr 2009; 60: 71–6.
26. Thornalley PJ. The potential role of thiamine (vitamin B1) in diabetic complications. Curr Diabetes Rev 2005; 1: 287–98.
27. Thornalley PJ, Babaei-Jadidi R, Al Ali H et al. High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease. Diabetologia 2007; 50: 2164–70.
28. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complication in patients with type 2 diabetes. (UKPDS 33). Lancet 1998; 352: 837–53.
2. Boulton AJM, Vileikyte L, Ragnarson-Tennwall G, Apelqvist J. The global burden of diabetic foot disease. Lancet 2005a; 366: 1719–24.
3. Boulton AJM, Vinik AI, Arezzo JC et al. Diabetic neuropathy. A statement by the American Diabetes Association. Diabetes Care 2005b; 28: 956–62.
4. Brownlee M. The pathobiology of diabetic complications. A unifying mechanism. Diabetes 2005; 54: 1615–25.
5. DCCT: The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329: 977–86.
6. De Jager J, Kooy A, Lehert P. Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial. BMJ 2010; 340. Doi: http://dx.doi.org/10.1136/bmj.c2181.
7. Dejgaard A. Pathophysiology and treatment of diabetic neuropathy. Diabet Med 1998; 15: 97–112.
8. Happich M, John J, Stamenitis S et al. The quality of life and economic burden of neuropathy in diabetic patients in Germany in 2002 – results from the Diabetic Microvascular Complications (DIMICO) study. Diabetes Res Clin Pract 2008; 81: 223–30.
9. Harati Y. Diabetes and the nervous system. Endocrinol Metab Clin North Am 1996; 25 (2): 325–59.
10. Holman RR, Paul SK, Bethel MA et al. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 2008; 359: 1577–89.
11. Kempler P (ed). Neuropathies. Pathomechanism, clinical presentation, diagnosis, therapy. Budapest: Springer Scientific Publisher, 2002.
12. Kibirige D, Mwebaze R. Vitamin B12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified? J Diabetes Metab Disord 2013; 12. http://www.jdmdonline.com/content/12/1/17
13. Mahajan R, Gupta K. Revisiting metformin: annual vitamin B12 supplementation may become mandatory with longterm metformin use. J Young Pharm 2010, 2: 428–9.
14. Marshall S, Flyvbjerg A. Prevention and early detection of vascular complications of diabetes. Brit Med J 2006; 333: 475–80.
15. McCandless DW. Thiamine Deficiency and Associated Clinical Disorders. Humana Press 2009.
16. Mooney S, Leuendorf J-E, Hendrickson C, Hellmann H. Vitamin B6: A Long Known Compound of Surprising Complexity Molecules 2009; 14: 329–51.
17. Pflipsen M, Oh R, Saguil A et al. The Prevalence of Vitamin B12 Deficiency in Patients with Type 2 Diabetes: a cross-sectional study. J Am Board Fam Med 2009; 22 (5): 528–34. Doi: 10.3122/jabfm.2009.05.090044. Erratum in: J Am Board Fam Med 2010; 23 (5): 695.
18. Reinstatler L, Qi YP, Williamson R, Garn JV et al. Association of Biochemical B12 Deficiency With Metformin Therapy and Vitamin B12 Supplements. Diabetes Care 2012; 35 (2): 327–33. Doi: 10.2337/dc11-1582.
19. Said G. Diabetic Neuropathy. A Review Nat Clin Pract Neurol 2007; 3 (6): 331–40.
20. Saito N, Kimura M, Kuchiba A, Itokawa Y. Blood thiamine levels in outpatients with diabetes mellitus. J Nutr Sci Vitaminol 1987; 33 (6): 421–31.
21. Shaw JE, Zimmet PZ. The epidemiology of diabetic neuropathy. Diabetes Reviews 1999; 7: 245–52.
22. Solomon LR. Disorders of cobalamin (vitamin B12) metabolism: emerging concept in patophysiology, diagnosis and treatment. Blood Rev 2007; 21: 113–30.
23. Stracke H, Lindemann A, Federlin K. A benfotiamine-vitamin B combination in the treatment of diabetic polyneuropathy. Exp Clin Endocrin Diabetes 1996; 104: 311–6.
24. Sun Y, Lai M, Lu C. Effectiveness of Vitamin B12 on Diabetic Neuropathy: Systematic Review of Clinical Controlled Trials. Acta Neurol Taiwan 2005, 14: 48–54.
25. Talaei A, Siavash M, Majidi H, Chehrei A. Vitamin B12 may be more effective than nortriptyline in improving painful diabetic neuropathy. Int J Food Sci Nutr 2009; 60: 71–6.
26. Thornalley PJ. The potential role of thiamine (vitamin B1) in diabetic complications. Curr Diabetes Rev 2005; 1: 287–98.
27. Thornalley PJ, Babaei-Jadidi R, Al Ali H et al. High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease. Diabetologia 2007; 50: 2164–70.
28. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complication in patients with type 2 diabetes. (UKPDS 33). Lancet 1998; 352: 837–53.
________________________________________________
2. Boulton AJM, Vileikyte L, Ragnarson-Tennwall G, Apelqvist J. The global burden of diabetic foot disease. Lancet 2005a; 366: 1719–24.
3. Boulton AJM, Vinik AI, Arezzo JC et al. Diabetic neuropathy. A statement by the American Diabetes Association. Diabetes Care 2005b; 28: 956–62.
4. Brownlee M. The pathobiology of diabetic complications. A unifying mechanism. Diabetes 2005; 54: 1615–25.
5. DCCT: The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329: 977–86.
6. De Jager J, Kooy A, Lehert P. Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial. BMJ 2010; 340. Doi: http://dx.doi.org/10.1136/bmj.c2181.
7. Dejgaard A. Pathophysiology and treatment of diabetic neuropathy. Diabet Med 1998; 15: 97–112.
8. Happich M, John J, Stamenitis S et al. The quality of life and economic burden of neuropathy in diabetic patients in Germany in 2002 – results from the Diabetic Microvascular Complications (DIMICO) study. Diabetes Res Clin Pract 2008; 81: 223–30.
9. Harati Y. Diabetes and the nervous system. Endocrinol Metab Clin North Am 1996; 25 (2): 325–59.
10. Holman RR, Paul SK, Bethel MA et al. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 2008; 359: 1577–89.
11. Kempler P (ed). Neuropathies. Pathomechanism, clinical presentation, diagnosis, therapy. Budapest: Springer Scientific Publisher, 2002.
12. Kibirige D, Mwebaze R. Vitamin B12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified? J Diabetes Metab Disord 2013; 12. http://www.jdmdonline.com/content/12/1/17
13. Mahajan R, Gupta K. Revisiting metformin: annual vitamin B12 supplementation may become mandatory with longterm metformin use. J Young Pharm 2010, 2: 428–9.
14. Marshall S, Flyvbjerg A. Prevention and early detection of vascular complications of diabetes. Brit Med J 2006; 333: 475–80.
15. McCandless DW. Thiamine Deficiency and Associated Clinical Disorders. Humana Press 2009.
16. Mooney S, Leuendorf J-E, Hendrickson C, Hellmann H. Vitamin B6: A Long Known Compound of Surprising Complexity Molecules 2009; 14: 329–51.
17. Pflipsen M, Oh R, Saguil A et al. The Prevalence of Vitamin B12 Deficiency in Patients with Type 2 Diabetes: a cross-sectional study. J Am Board Fam Med 2009; 22 (5): 528–34. Doi: 10.3122/jabfm.2009.05.090044. Erratum in: J Am Board Fam Med 2010; 23 (5): 695.
18. Reinstatler L, Qi YP, Williamson R, Garn JV et al. Association of Biochemical B12 Deficiency With Metformin Therapy and Vitamin B12 Supplements. Diabetes Care 2012; 35 (2): 327–33. Doi: 10.2337/dc11-1582.
19. Said G. Diabetic Neuropathy. A Review Nat Clin Pract Neurol 2007; 3 (6): 331–40.
20. Saito N, Kimura M, Kuchiba A, Itokawa Y. Blood thiamine levels in outpatients with diabetes mellitus. J Nutr Sci Vitaminol 1987; 33 (6): 421–31.
21. Shaw JE, Zimmet PZ. The epidemiology of diabetic neuropathy. Diabetes Reviews 1999; 7: 245–52.
22. Solomon LR. Disorders of cobalamin (vitamin B12) metabolism: emerging concept in patophysiology, diagnosis and treatment. Blood Rev 2007; 21: 113–30.
23. Stracke H, Lindemann A, Federlin K. A benfotiamine-vitamin B combination in the treatment of diabetic polyneuropathy. Exp Clin Endocrin Diabetes 1996; 104: 311–6.
24. Sun Y, Lai M, Lu C. Effectiveness of Vitamin B12 on Diabetic Neuropathy: Systematic Review of Clinical Controlled Trials. Acta Neurol Taiwan 2005, 14: 48–54.
25. Talaei A, Siavash M, Majidi H, Chehrei A. Vitamin B12 may be more effective than nortriptyline in improving painful diabetic neuropathy. Int J Food Sci Nutr 2009; 60: 71–6.
26. Thornalley PJ. The potential role of thiamine (vitamin B1) in diabetic complications. Curr Diabetes Rev 2005; 1: 287–98.
27. Thornalley PJ, Babaei-Jadidi R, Al Ali H et al. High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease. Diabetologia 2007; 50: 2164–70.
28. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complication in patients with type 2 diabetes. (UKPDS 33). Lancet 1998; 352: 837–53.
Авторы
Е.В.Бирюкова*, Т.Р.Ягубова
ГБОУ ВПО Московский государственный медико-стоматологический университет им. А.И.Евдокимова Минздрава России. 127473, Россия, Москва, ул. Делегатская, д. 20, стр.1
*lena@obsudim.ru
A.I.Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation. 127473, Russian Federation, Moscow, ul. Delegatskaia, d. 20, str. 1
*lena@obsudim.ru
ГБОУ ВПО Московский государственный медико-стоматологический университет им. А.И.Евдокимова Минздрава России. 127473, Россия, Москва, ул. Делегатская, д. 20, стр.1
*lena@obsudim.ru
________________________________________________
A.I.Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation. 127473, Russian Federation, Moscow, ul. Delegatskaia, d. 20, str. 1
*lena@obsudim.ru
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