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Применение комбинации антибиотиков широкого спектра действия для наружного лечения пиодермий
Применение комбинации антибиотиков широкого спектра действия для наружного лечения пиодермий
Касихина Е.И. Применение комбинации антибиотиков широкого спектра действия для наружного лечения пиодермий.
Consilium Medicum. Дерматология (Прил.). 2015; 2: 5–10.
Consilium Medicum. Дерматология (Прил.). 2015; 2: 5–10.
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Аннотация
Пиодермии – гнойничковые болезни кожи – инфекционные заболевания кожи, развивающиеся в результате внедрения в нее пиококков. Возбудителями пиодермитов являются стафилококки (Staphylococcus аureus, Staphylococcus epidermidis), β-гемолитические стрептококки (Streptococcus pyogenes) и др. Диагностика и терапия инфекционных поражений стафилококковой природы представляет непростую задачу для врача, связанную среди ряда причин и с резистентностью возбудителя. Хорошо известно, что в последнее десятилетие чувствительность S. аureus снизилась к известным антибактериальным средствам: левомицетину, эритромицину, тетрациклину, гентамицину и др. Большинство европейских руководств рекомендует начинать лечение импетиго и других пиодермий с использования топических антибиотиков. В развитых странах используются комбинированные мази, содержащие в своем составе три топических антибиотика. Как правило, целью такой комбинации является синергизм действия антибиотиков. Например, для неомицина возможны сочетания с одним из перечисленных антибиотиков: ампициллин, прокаин пенициллин, грамицидин, бацитрацин, окситетрациклин, линкомицин, эритромицин. Одним из немногих доступных для использования в России комбинированных топических антибактериальных средств, в состав которых включены бацитрацин и неомицин, является препарат Банеоцин®.
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Полный текст
Список литературы
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12. Козлов Р.С., Сивая О.В., Шпынев К.В. и др. Антибиотикорезистентность Streptococcus pyogenes в России: результаты многоцентрового проспективного исследования ПеГАС-I. Клин. микробиол. антимикроб. химиотер. 2002; 4 (2): 154–67. / Kozlov R.S., Sivaia O.V., Shpynev K.V. i dr. Antibiotikorezistentnost' Streptococcus pyogenes v Rossii: rezul'taty mnogotsentrovogo prospektivnogo issledovaniia PeGAS-I. Klin. mikrobiol. antimikrob. khimioter. 2002; 4 (2): 154–67. [in Russian]
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15. Van Bijnen EME, Paget J, den Heijer CDJ et al in collaboration with the APRES study team: Evidence-based primary care treatment guidelines for skin infections in Europe: a comparative analysis. Eur J Gen Pract 2014. In press.
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18. Grzybowska W, Wojcik A, Tyski S. Interaction of neomycin with other antibiotics on selected bacterial strains. Med Dosw Mikrobiol 2004; 56 (2): 187–98.
19. Tianhong Dai, Ying-Ying Huang, Sulbha K. Sharma et al. Topical Antimicrobials for Burn Wound Infections. Recent Pat Antiinfect Drug Discov 2010; 5 (2): 124–51.
20. Hammond AA, Miller KG, Kruczek CJ et al. An in vitro biofilm model to examine the effect of antibiotic ointments on biofilms produced by burn wound bacterial isolates. Burns 2011; 37 (2): 312–21.
21. Neely AN, Gardner J, Durkee P et al. Are topical antimicrobials effective against bacteria that are highly resistant to systemic antibiotics? J Burn Care Res 2009; 30 (1): 19–29.
22. Hendley JO, Ashe KM. Eradication of resident bacteria of normal human skin by antimicrobial ointment. Antimicrob Agents Chemother 2003; 47 (6): 1988–90.
23. Winkelman W, Gratton D. Topical antibacterials. Clin Dermatol 1989; 7 (3): 156–62.
24. European Committee on Antimicrobial Susceptibility Testing. Neomycin/Staphylococcus aureus EUCAST MIC Distribution – Reference Database 2013-02-25. URL: mic.eucast.org/Eucast2/regShow.jsp?Id=9628.
25. Cesur S. Topical antibiotics and clinical use. Mikrobiyol Bul 2002; 36 (3–4): 353–61.
26. Spann CT, Taylor SC, Weinberg JM. Topical antimicrobial agents in dermatology. Dis Mon 2004; 50 (7): 407–21.
27. Привольнев В.В., Забросаев В.С., Даниленков Н.В. Патогенетический подход к лечению ран: учебное пособие. Смоленск: СГМА, 2013. / Privol'nev V.V., Zabrosaev V.S., Danilenkov N.V. Patogeneticheskii podkhod k lecheniiu ran: uchebnoe posobie. Smolensk: SGMA, 2013. [in Russian]
28. Khoruk SM, Krechikov VA. Results of using the combined medicine bacitracin+neomycin in the postoperative period after cosmetic surgery correcting maxillofacial soft tissue defects. Khirurgiia (Moscow). 2008; 12: 47–50.
29. Паршина В.Л. Профилактика и лечение гнойно-септических заболеваний кожи, подкожной клетчатки и пупочной ранки в практике неонатальной реанимации. Consilium Medicum. Педиатрия (Прил.). 2007; 1: 4–8. / Parshina V.L. Profilaktika i lechenie gnoino-septicheskikh zabolevanii kozhi, podkozhnoi kletchatki i pupochnoi ranki v praktike neonatal'noi reanimatsii. Consilium Medicum. Pediatriia (Pril.). 2007; 1: 4–8. [in Russian]
30. Селисский А.Б. Лечение заболеваний кожи и рецептура. Справочник для врачей. Минск: Изд-во Академии наук Белорусской ССР, 1955. / Selisskii A.B. Lechenie zabolevanii kozhi i retseptura. Spravochnik dlia vrachei. Minsk: Izd-vo Akademii nauk Belorusskoi SSR, 1955. [in Russian]
2. Grossman EM, Nanda S, Gordon JR. Clearance of nasal Staphylococcus aureus colonization with triple antibiotic ointment. J Drugs Dermatol 2012; 11 (12): 1490–2.
3. David MZ, Daum RS. Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic. Clin Microbiol Rev 2010; 23: 616–87.
4. Diep BA, Stone GG, Basuino L et al. The arginine catabolic mobile element and staphylococcal chromosomal cassette mec linkage: convergence of virulence and resistance in the USA300 clone of methicillin-resistant Staphylococcus aureus. J Infect Dis 2008; 197: 1523–30.
5. O'Reilly EB, Johnson MD, Rohrich RJ. Comprehensive review of methicillin-resistant Staphylococcus aureus: screening and preventive recommendations for plastic surgeons and other surgical health care providers. Plast Reconstr Surg 2014; 134 (5): 1078–89.
6. Kaplan SL, Hulten KG, Gonzalez BE et al. Three-year surveillance of community-acquired methicillin-resistant Staphylococcus aureus in children. Clin Infect Dis 2005; 40: 1785–91.
7. Jun Lin, Kunihiko Nishino, Roberts MC et al. Mechanisms of antibiotic resistancе. Front Microbiol 2015; 6 (34): 1–3.
8. Den Heijer CDJ, van Bijnen EME, Paget WJ et al. APRES Study Team: Prevalence and resistance of commensal Staphylococcus aureus, including meticillin-resistant Staphylococcus aureus: a European cross-sectional study. Lancet Infect Dis 2013; 13: 409–15.
9. Iwaki M, Noguchi N, Nakaminami H et al. Antimicrobial activity and frequency of spontaneous gentamicin-resistant mutants in bacteria related skin infections. Yakugaku Zasshi 2011; 131 (11): 1653–9.
10. Strachunskii L.S., Dekhnich A.V., Bel'kova Iu.A., gruppa issledovatelei proekta StEnt. Sravnitel'naia aktivnost' antibakterial'nykh preparatov, vkhodiashchikh v lekarstvennye formy dlia mestnogo primeneniia, v otnoshenii Staphylococcus aureus: rezul'taty rossiiskogo mnogotsentrovogo issledovaniia. Klin. mikrobiol. antimikrob. khimioter. 2002; 4 (2): 157–63. [in Russian]
11. Stratchounski LS, Belkova JA, Cigankova EP. Etiology and аntimicrobial resistance of pathogens of skin and soft tissue infections in outpatients: results of first prospective study in Russia. J Chemother 2005; 17 (Suppl. 3): 73–4.
12. Kozlov R.S., Sivaia O.V., Shpynev K.V. i dr. Antibiotikorezistentnost' Streptococcus pyogenes v Rossii: rezul'taty mnogotsentrovogo prospektivnogo issledovaniia PeGAS-I. Klin. mikrobiol. antimikrob. khimioter. 2002; 4 (2): 154–67. [in Russian]
13. Bearden DT, Allen GP, Christensen JM. Comparative in vitro activities of topical wound care products against community-associated methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother 2008; 62: 769–72.
14. Van Bijnen EM, Paget WJ, den Heijer CD et al. Primary care treatment guidelines for skin infections in Europe: congruence with antimicrobial resistance found in commensal Staphylococcus aureus in the community. BMC Family Practice 2014; 15: 175–83.
15. Van Bijnen EME, Paget J, den Heijer CDJ et al in collaboration with the APRES study team: Evidence-based primary care treatment guidelines for skin infections in Europe: a comparative analysis. Eur J Gen Pract 2014. In press.
16. Jones RN, Li Q, Kohut B et al. Contemporary antimicrobial activity of triple antibiotic ointment: a multiphased study of recent clinical isolates in the United States and Australia. Diagn Microbiol Infect Dis 2006; 54 (1): 63–71.
17. Bonomo RA, van Zile PS, Li Q et al. Topical triple-antibiotic ointment as a novel therapeutic choice in wound management and infection prevention: a practical perspective. Expert Rev Anti Infect Ther 2007; 5 (5): 773–82.
18. Grzybowska W, Wojcik A, Tyski S. Interaction of neomycin with other antibiotics on selected bacterial strains. Med Dosw Mikrobiol 2004; 56 (2): 187–98.
19. Tianhong Dai, Ying-Ying Huang, Sulbha K. Sharma et al. Topical Antimicrobials for Burn Wound Infections. Recent Pat Antiinfect Drug Discov 2010; 5 (2): 124–51.
20. Hammond AA, Miller KG, Kruczek CJ et al. An in vitro biofilm model to examine the effect of antibiotic ointments on biofilms produced by burn wound bacterial isolates. Burns 2011; 37 (2): 312–21.
21. Neely AN, Gardner J, Durkee P et al. Are topical antimicrobials effective against bacteria that are highly resistant to systemic antibiotics? J Burn Care Res 2009; 30 (1): 19–29.
22. Hendley JO, Ashe KM. Eradication of resident bacteria of normal human skin by antimicrobial ointment. Antimicrob Agents Chemother 2003; 47 (6): 1988–90.
23. Winkelman W, Gratton D. Topical antibacterials. Clin Dermatol 1989; 7 (3): 156–62.
24. European Committee on Antimicrobial Susceptibility Testing. Neomycin/Staphylococcus aureus EUCAST MIC Distribution – Reference Database 2013-02-25. URL: mic.eucast.org/Eucast2/regShow.jsp?Id=9628.
25. Cesur S. Topical antibiotics and clinical use. Mikrobiyol Bul 2002; 36 (3–4): 353–61.
26. Spann CT, Taylor SC, Weinberg JM. Topical antimicrobial agents in dermatology. Dis Mon 2004; 50 (7): 407–21.
27. Privol'nev V.V., Zabrosaev V.S., Danilenkov N.V. Patogeneticheskii podkhod k lecheniiu ran: uchebnoe posobie. Smolensk: SGMA, 2013. [in Russian]
28. Khoruk SM, Krechikov VA. Results of using the combined medicine bacitracin+neomycin in the postoperative period after cosmetic surgery correcting maxillofacial soft tissue defects. Khirurgiia (Moscow). 2008; 12: 47–50.
29. Parshina V.L. Profilaktika i lechenie gnoino-septicheskikh zabolevanii kozhi, podkozhnoi kletchatki i pupochnoi ranki v praktike neonatal'noi reanimatsii. Consilium Medicum. Pediatriia (Pril.). 2007; 1: 4–8. [in Russian]
30. Selisskii A.B. Lechenie zabolevanii kozhi i retseptura. Spravochnik dlia vrachei. Minsk: Izd-vo Akademii nauk Belorusskoi SSR, 1955. [in Russian]
2. Grossman EM, Nanda S, Gordon JR. Clearance of nasal Staphylococcus aureus colonization with triple antibiotic ointment. J Drugs Dermatol 2012; 11 (12): 1490–2.
3. David MZ, Daum RS. Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic. Clin Microbiol Rev 2010; 23: 616–87.
4. Diep BA, Stone GG, Basuino L et al. The arginine catabolic mobile element and staphylococcal chromosomal cassette mec linkage: convergence of virulence and resistance in the USA300 clone of methicillin-resistant Staphylococcus aureus. J Infect Dis 2008; 197: 1523–30.
5. O'Reilly EB, Johnson MD, Rohrich RJ. Comprehensive review of methicillin-resistant Staphylococcus aureus: screening and preventive recommendations for plastic surgeons and other surgical health care providers. Plast Reconstr Surg 2014; 134 (5): 1078–89.
6. Kaplan SL, Hulten KG, Gonzalez BE et al. Three-year surveillance of community-acquired methicillin-resistant Staphylococcus aureus in children. Clin Infect Dis 2005; 40: 1785–91.
7. Jun Lin, Kunihiko Nishino, Roberts MC et al. Mechanisms of antibiotic resistancе. Front Microbiol 2015; 6 (34): 1–3.
8. Den Heijer CDJ, van Bijnen EME, Paget WJ et al. APRES Study Team: Prevalence and resistance of commensal Staphylococcus aureus, including meticillin-resistant Staphylococcus aureus: a European cross-sectional study. Lancet Infect Dis 2013; 13: 409–15.
9. Iwaki M, Noguchi N, Nakaminami H et al. Antimicrobial activity and frequency of spontaneous gentamicin-resistant mutants in bacteria related skin infections. Yakugaku Zasshi 2011; 131 (11): 1653–9.
10. Страчунский Л.С., Дехнич А.В., Белькова Ю.А., группа исследователей проекта СтЭнт. Сравнительная активность антибактериальных препаратов, входящих в лекарственные формы для местного применения, в отношении Staphylococcus aureus: результаты российского многоцентрового исследования. Клин. микробиол. антимикроб. химиотер. 2002; 4 (2): 157–63. / Strachunskii L.S., Dekhnich A.V., Bel'kova Iu.A., gruppa issledovatelei proekta StEnt. Sravnitel'naia aktivnost' antibakterial'nykh preparatov, vkhodiashchikh v lekarstvennye formy dlia mestnogo primeneniia, v otnoshenii Staphylococcus aureus: rezul'taty rossiiskogo mnogotsentrovogo issledovaniia. Klin. mikrobiol. antimikrob. khimioter. 2002; 4 (2): 157–63. [in Russian]
11. Stratchounski LS, Belkova JA, Cigankova EP. Etiology and аntimicrobial resistance of pathogens of skin and soft tissue infections in outpatients: results of first prospective study in Russia. J Chemother 2005; 17 (Suppl. 3): 73–4.
12. Козлов Р.С., Сивая О.В., Шпынев К.В. и др. Антибиотикорезистентность Streptococcus pyogenes в России: результаты многоцентрового проспективного исследования ПеГАС-I. Клин. микробиол. антимикроб. химиотер. 2002; 4 (2): 154–67. / Kozlov R.S., Sivaia O.V., Shpynev K.V. i dr. Antibiotikorezistentnost' Streptococcus pyogenes v Rossii: rezul'taty mnogotsentrovogo prospektivnogo issledovaniia PeGAS-I. Klin. mikrobiol. antimikrob. khimioter. 2002; 4 (2): 154–67. [in Russian]
13. Bearden DT, Allen GP, Christensen JM. Comparative in vitro activities of topical wound care products against community-associated methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother 2008; 62: 769–72.
14. Van Bijnen EM, Paget WJ, den Heijer CD et al. Primary care treatment guidelines for skin infections in Europe: congruence with antimicrobial resistance found in commensal Staphylococcus aureus in the community. BMC Family Practice 2014; 15: 175–83.
15. Van Bijnen EME, Paget J, den Heijer CDJ et al in collaboration with the APRES study team: Evidence-based primary care treatment guidelines for skin infections in Europe: a comparative analysis. Eur J Gen Pract 2014. In press.
16. Jones RN, Li Q, Kohut B et al. Contemporary antimicrobial activity of triple antibiotic ointment: a multiphased study of recent clinical isolates in the United States and Australia. Diagn Microbiol Infect Dis 2006; 54 (1): 63–71.
17. Bonomo RA, van Zile PS, Li Q et al. Topical triple-antibiotic ointment as a novel therapeutic choice in wound management and infection prevention: a practical perspective. Expert Rev Anti Infect Ther 2007; 5 (5): 773–82.
18. Grzybowska W, Wojcik A, Tyski S. Interaction of neomycin with other antibiotics on selected bacterial strains. Med Dosw Mikrobiol 2004; 56 (2): 187–98.
19. Tianhong Dai, Ying-Ying Huang, Sulbha K. Sharma et al. Topical Antimicrobials for Burn Wound Infections. Recent Pat Antiinfect Drug Discov 2010; 5 (2): 124–51.
20. Hammond AA, Miller KG, Kruczek CJ et al. An in vitro biofilm model to examine the effect of antibiotic ointments on biofilms produced by burn wound bacterial isolates. Burns 2011; 37 (2): 312–21.
21. Neely AN, Gardner J, Durkee P et al. Are topical antimicrobials effective against bacteria that are highly resistant to systemic antibiotics? J Burn Care Res 2009; 30 (1): 19–29.
22. Hendley JO, Ashe KM. Eradication of resident bacteria of normal human skin by antimicrobial ointment. Antimicrob Agents Chemother 2003; 47 (6): 1988–90.
23. Winkelman W, Gratton D. Topical antibacterials. Clin Dermatol 1989; 7 (3): 156–62.
24. European Committee on Antimicrobial Susceptibility Testing. Neomycin/Staphylococcus aureus EUCAST MIC Distribution – Reference Database 2013-02-25. URL: mic.eucast.org/Eucast2/regShow.jsp?Id=9628.
25. Cesur S. Topical antibiotics and clinical use. Mikrobiyol Bul 2002; 36 (3–4): 353–61.
26. Spann CT, Taylor SC, Weinberg JM. Topical antimicrobial agents in dermatology. Dis Mon 2004; 50 (7): 407–21.
27. Привольнев В.В., Забросаев В.С., Даниленков Н.В. Патогенетический подход к лечению ран: учебное пособие. Смоленск: СГМА, 2013. / Privol'nev V.V., Zabrosaev V.S., Danilenkov N.V. Patogeneticheskii podkhod k lecheniiu ran: uchebnoe posobie. Smolensk: SGMA, 2013. [in Russian]
28. Khoruk SM, Krechikov VA. Results of using the combined medicine bacitracin+neomycin in the postoperative period after cosmetic surgery correcting maxillofacial soft tissue defects. Khirurgiia (Moscow). 2008; 12: 47–50.
29. Паршина В.Л. Профилактика и лечение гнойно-септических заболеваний кожи, подкожной клетчатки и пупочной ранки в практике неонатальной реанимации. Consilium Medicum. Педиатрия (Прил.). 2007; 1: 4–8. / Parshina V.L. Profilaktika i lechenie gnoino-septicheskikh zabolevanii kozhi, podkozhnoi kletchatki i pupochnoi ranki v praktike neonatal'noi reanimatsii. Consilium Medicum. Pediatriia (Pril.). 2007; 1: 4–8. [in Russian]
30. Селисский А.Б. Лечение заболеваний кожи и рецептура. Справочник для врачей. Минск: Изд-во Академии наук Белорусской ССР, 1955. / Selisskii A.B. Lechenie zabolevanii kozhi i retseptura. Spravochnik dlia vrachei. Minsk: Izd-vo Akademii nauk Belorusskoi SSR, 1955. [in Russian]
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2. Grossman EM, Nanda S, Gordon JR. Clearance of nasal Staphylococcus aureus colonization with triple antibiotic ointment. J Drugs Dermatol 2012; 11 (12): 1490–2.
3. David MZ, Daum RS. Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic. Clin Microbiol Rev 2010; 23: 616–87.
4. Diep BA, Stone GG, Basuino L et al. The arginine catabolic mobile element and staphylococcal chromosomal cassette mec linkage: convergence of virulence and resistance in the USA300 clone of methicillin-resistant Staphylococcus aureus. J Infect Dis 2008; 197: 1523–30.
5. O'Reilly EB, Johnson MD, Rohrich RJ. Comprehensive review of methicillin-resistant Staphylococcus aureus: screening and preventive recommendations for plastic surgeons and other surgical health care providers. Plast Reconstr Surg 2014; 134 (5): 1078–89.
6. Kaplan SL, Hulten KG, Gonzalez BE et al. Three-year surveillance of community-acquired methicillin-resistant Staphylococcus aureus in children. Clin Infect Dis 2005; 40: 1785–91.
7. Jun Lin, Kunihiko Nishino, Roberts MC et al. Mechanisms of antibiotic resistancе. Front Microbiol 2015; 6 (34): 1–3.
8. Den Heijer CDJ, van Bijnen EME, Paget WJ et al. APRES Study Team: Prevalence and resistance of commensal Staphylococcus aureus, including meticillin-resistant Staphylococcus aureus: a European cross-sectional study. Lancet Infect Dis 2013; 13: 409–15.
9. Iwaki M, Noguchi N, Nakaminami H et al. Antimicrobial activity and frequency of spontaneous gentamicin-resistant mutants in bacteria related skin infections. Yakugaku Zasshi 2011; 131 (11): 1653–9.
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Авторы
Е.И.Касихина*
ФГБУ ДПО Учебно-научный медицинский центр Управления делами Президента Российской Федерации. 121359, Россия, Москва, ул. Маршала Тимошенко, д. 21
*kasprof@bk.ru
Educational science and medical centre Management of Affairs of the President Russian Federation. 121359, Russian Federation, Moscow, ul. Marshala Timoshenko, d. 21
*kasprof@bk.ru
ФГБУ ДПО Учебно-научный медицинский центр Управления делами Президента Российской Федерации. 121359, Россия, Москва, ул. Маршала Тимошенко, д. 21
*kasprof@bk.ru
________________________________________________
Educational science and medical centre Management of Affairs of the President Russian Federation. 121359, Russian Federation, Moscow, ul. Marshala Timoshenko, d. 21
*kasprof@bk.ru
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