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Макронодулярная двусторонняя гиперплазия надпочечников: диагностика аберрантных рецепторов и современные аспекты лечения*
Юкина М.Ю., Нуралиева Н.Ф., Бельцевич Д.Г. и др. Макронодулярная двусторонняя гиперплазия надпочечников: диагностика аберрантных рецепторов и современные аспекты лечения. Consilium Medicum. 2016; 18 (10): 29–33. DOI: 10.26442/2075-1753_2016.10.29-33
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Yukina M.Yu., Nuralieva N.F., Beltsevich D.G. et al. Macronodular bilateral adrenal hyperplasia: diagnose the aberrant receptors and current aspects of treatment. Consilium Medicum. 2016; 18 (10): 29–33. DOI: 10.26442/2075-1753_2016.10.29-33
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Аннотация
Для диагностики аберрантных рецепторов у больных макронодулярной двусторонней гиперплазией надпочечников (МДГН) перспективно проведение лигандиндуцированных тестов. С учетом специфики выявленных рецепторов возможно назначение консервативной терапии. Однако использование специфических антагонистов аберрантных рецепторов ограничено недостаточным количеством данных о эффективности медикаментозного лечения, а также побочными эффектами лекарственных препаратов. Таким образом, в настоящее время не выработана единая тактика ведения пациентов с МДГН. Актуально проведение исследований, в том числе геномных, направленных на усовершенствование своевременной диагностики заболевания, разработку новых терапевтических и потенциально профилактических мер в отношении МДГН.
Ключевые слова: макронодулярная двусторонняя гиперплазия надпочечников, диагностика аберрантных мембранных рецепторов.
Ключевые слова: макронодулярная двусторонняя гиперплазия надпочечников, диагностика аберрантных мембранных рецепторов.
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The investigation strategy for identification the specific expression of aberrant receptors includes ligand-induced tests. The identification of aberrant receptors provides an opportunity for new pharmacological therapeutic strategies. However, the specific aberrant receptors antagonists administration is limited due to the insufficient data on the effectiveness of medication, and side effects of drugs. Currently there is no unified approach of the management of patients with MBAH. Thus, researches, including genomic, directed at improvement of timely diagnostics of disease and development of new therapeutic and potentially preventive measures against MBAH, are topical.
Key words: macronodular bilateral adrenal hyperplasia, diagnose the aberrant membrane receptors.
Key words: macronodular bilateral adrenal hyperplasia, diagnose the aberrant membrane receptors.
Полный текст
Список литературы
1. Louiset E, Lefebvre H. Intraadrenal corticotropin in bilateral macronodular adrenal hyperplasia. N Engl J Med 2014; 370 (11): 1071–2.
2. Cavagnini F, Giraldi FP. Adrenal Causes of Cushing’s Syndrome. In: Jameson JL, De Groot LG, editors. Endocrinology: Adult and Pediatric. 7th Edition. 2015; р. 1775–809.
3. Lacroix A, Ndiaye N, Tremblay J, Hamet P. Ectopic and abnormal hormone receptors in adrenal Cushing’s syndrome. Endocr Rev 2001; 22: 75–110.
4. Elbelt U, Trovato A, Kloth M. Molecular and clinical evidence for an ARMC5 tumor syndrome: concurrent inactivating germline and somatic mutations are associated with both primary macronodular adrenal hyperplasia and meningioma. J Clin Endocrinol Metab 2015; 100 (1): E119–28.
5. Lacroix A, Costa MHS. Cushing’s Syndrome Secondary to ACTH-Independent Macronodular Adrenal Hyperplasia. Arq Bras Endocrinol Metab 2007; 51 (8): 1226–37.
6. Albiger NM, Occhi G, Mariniello В et al. Food-dependent Cushing’s syndrome: from molecular characterization to therapeutical results. Eur J Endocrinol 2007; 157 (6): 771–8.
7. Christopoulos S, Bourdeau I, Lacroix A. Clinical and subclinical ACTH-independent macronodular adrenal hyperplasia and aberrant hormone receptors. Horm Res 2005; 64 (3): 119–31.
8. Christopoulos S, Bourdeau I, Lacroix A. Aberrant Expression of Hormone Receptors in Adrenal Cushing's Syndrome. Pituitary 2004; 7 (4): 225–35.
9. Fujii H, Tamamori-Adachi M, Uchida K et al. Marked Cortisol Production by Intracrine ACTH in GIPTreated Cultured Adrenal Cells in Which the GIP Receptor Was Exogenously Introduced. PLOS ONE 2014; 9 (10).
10. Tock L, Carneiro G, Pereira AZ et al. Adrenocortical Production Is Associated with Higher Levels of Luteinizing Hormone in Nonobese Women with Polycystic Ovary Syndrome. Int J Endocrinol 2014.
2. Cavagnini F, Giraldi FP. Adrenal Causes of Cushing’s Syndrome. In: Jameson JL, De Groot LG, editors. Endocrinology: Adult and Pediatric. 7th Edition. 2015; р. 1775–809.
3. Lacroix A, Ndiaye N, Tremblay J, Hamet P. Ectopic and abnormal hormone receptors in adrenal Cushing’s syndrome. Endocr Rev 2001; 22: 75–110.
4. Elbelt U, Trovato A, Kloth M. Molecular and clinical evidence for an ARMC5 tumor syndrome: concurrent inactivating germline and somatic mutations are associated with both primary macronodular adrenal hyperplasia and meningioma. J Clin Endocrinol Metab 2015; 100 (1): E119–28.
5. Lacroix A, Costa MHS. Cushing’s Syndrome Secondary to ACTH-Independent Macronodular Adrenal Hyperplasia. Arq Bras Endocrinol Metab 2007; 51 (8): 1226–37.
6. Albiger NM, Occhi G, Mariniello В et al. Food-dependent Cushing’s syndrome: from molecular characterization to therapeutical results. Eur J Endocrinol 2007; 157 (6): 771–8.
7. Christopoulos S, Bourdeau I, Lacroix A. Clinical and subclinical ACTH-independent macronodular adrenal hyperplasia and aberrant hormone receptors. Horm Res 2005; 64 (3): 119–31.
8. Christopoulos S, Bourdeau I, Lacroix A. Aberrant Expression of Hormone Receptors in Adrenal Cushing's Syndrome. Pituitary 2004; 7 (4): 225–35.
9. Fujii H, Tamamori-Adachi M, Uchida K et al. Marked Cortisol Production by Intracrine ACTH in GIPTreated Cultured Adrenal Cells in Which the GIP Receptor Was Exogenously Introduced. PLOS ONE 2014; 9 (10).
10. Tock L, Carneiro G, Pereira AZ et al. Adrenocortical Production Is Associated with Higher Levels of Luteinizing Hormone in Nonobese Women with Polycystic Ovary Syndrome. Int J Endocrinol 2014.
________________________________________________
1. Louiset E, Lefebvre H. Intraadrenal corticotropin in bilateral macronodular adrenal hyperplasia. N Engl J Med 2014; 370 (11): 1071–2.
2. Cavagnini F, Giraldi FP. Adrenal Causes of Cushing’s Syndrome. In: Jameson JL, De Groot LG, editors. Endocrinology: Adult and Pediatric. 7th Edition. 2015; р. 1775–809.
3. Lacroix A, Ndiaye N, Tremblay J, Hamet P. Ectopic and abnormal hormone receptors in adrenal Cushing’s syndrome. Endocr Rev 2001; 22: 75–110.
4. Elbelt U, Trovato A, Kloth M. Molecular and clinical evidence for an ARMC5 tumor syndrome: concurrent inactivating germline and somatic mutations are associated with both primary macronodular adrenal hyperplasia and meningioma. J Clin Endocrinol Metab 2015; 100 (1): E119–28.
5. Lacroix A, Costa MHS. Cushing’s Syndrome Secondary to ACTH-Independent Macronodular Adrenal Hyperplasia. Arq Bras Endocrinol Metab 2007; 51 (8): 1226–37.
6. Albiger NM, Occhi G, Mariniello В et al. Food-dependent Cushing’s syndrome: from molecular characterization to therapeutical results. Eur J Endocrinol 2007; 157 (6): 771–8.
7. Christopoulos S, Bourdeau I, Lacroix A. Clinical and subclinical ACTH-independent macronodular adrenal hyperplasia and aberrant hormone receptors. Horm Res 2005; 64 (3): 119–31.
8. Christopoulos S, Bourdeau I, Lacroix A. Aberrant Expression of Hormone Receptors in Adrenal Cushing's Syndrome. Pituitary 2004; 7 (4): 225–35.
9. Fujii H, Tamamori-Adachi M, Uchida K et al. Marked Cortisol Production by Intracrine ACTH in GIPTreated Cultured Adrenal Cells in Which the GIP Receptor Was Exogenously Introduced. PLOS ONE 2014; 9 (10).
10. Tock L, Carneiro G, Pereira AZ et al. Adrenocortical Production Is Associated with Higher Levels of Luteinizing Hormone in Nonobese Women with Polycystic Ovary Syndrome. Int J Endocrinol 2014.
Авторы
М.Ю.Юкина*, Н.Ф.Нуралиева, Д.Г.Бельцевич, Е.А.Трошина, Н.М.Платонова
ФГБУ Эндокринологический научный центр Минздрава России. 117036, Россия, Москва, ул. Дмитрия Ульянова, д. 11
kuronova@yandex.ru
ФГБУ Эндокринологический научный центр Минздрава России. 117036, Россия, Москва, ул. Дмитрия Ульянова, д. 11
kuronova@yandex.ru
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M.Yu.Yukina*, N.F.Nuralieva, D.G.Beltsevich, E.A.Troshina, N.M.Platonova
Endocrinology Research Center of the Ministry of Health of the Russian Federation. 117036, Russian Federation, Moscow, ul. Dmitria Ul'ianova, d. 11
kuronova@yandex.ru
Endocrinology Research Center of the Ministry of Health of the Russian Federation. 117036, Russian Federation, Moscow, ul. Dmitria Ul'ianova, d. 11
kuronova@yandex.ru
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