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Повышение эффективности ноотропной терапии
Повышение эффективности ноотропной терапии
Шавловская О.А. Повышение эффективности ноотропной терапии. Consilium Medicum. 2016; 18 (12): 68–72. DOI: 10.26442/2075-1753_2016.12.68-72
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Аннотация
Традиционно для лечения когнитивной недостаточности неврологи назначают ноотропные препараты. Для достижения большего эффекта оправдано сочетание нескольких препаратов (ноотроп + витаминно-минеральный комплекс) с различными механизмами действия, проявляющими синергию действия. Комплексы витаминов группы В и С, макро- и микроэлементов (кальций, магний, цинк), а также фолиевая кислота, входящие в состав витаминно-минеральных комплексов, обладают активирующим действием, оказывая положительное влияние на когнитивные функции и такие симптомы, как астения, изменение эмоционального фона настроения, повышенная чувствительность к стрессу, тревожность.
Ключевые слова: поливитаминный комплекс, когнитивные нарушения, витамины группы В, микроэлементы.
Ключевые слова: поливитаминный комплекс, когнитивные нарушения, витамины группы В, микроэлементы.
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Traditionally, for the treatment of cognitive deficits neurologists prescribed nootropics. In order to achieve greater effect, the combination of several drugs (nootrop + vitamin and mineral complex) with different mechanisms of action, exhibiting a synergy of action was rightfully chosen. Complexes of vitamins B and C, macro- and micronutrients (calcium, magnesium, zinc), as well as folic acid, are part of the vitamin-mineral complexes, have an activating effect, exerting a positive influence on cognitive function and symptoms such as fatigue, change emotional background of mood, increased sensitivity to stress and anxiety.
Key words: multivitamin complex, cognitive impairment, B vitamins, trace elements.
Key words: multivitamin complex, cognitive impairment, B vitamins, trace elements.
Полный текст
Список литературы
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3. Пизова Н.В. Когнитивные нарушения при некоторых распространенных соматических заболеваниях: когнитивный резерв и терапевтические подходы. Consilium Medicum. Неврология и Ревматология (Прил.). 2015; 2: 27–32. / Pizova N.V. Kognitivnye narusheniia pri nekotorykh rasprostranennykh somaticheskikh zabolevaniiakh: kognitivnyi rezerv i terapevticheskie podkhody. Consilium Medicum. Neurology and Rheumatology (Suppl.). 2015; 2: 27–32. [in Russian]
4. Шавловская О.А. Терапия астении и связанных с ней состояний препаратами витаминно-минерального комплекса. Мед. совет. 2015; 17: 55–61. / Shavlovskaia O.A. Terapiia astenii i sviazannykh s nei sostoianii preparatami vitaminno-mineral'nogo kompleksa. Med. sovet. 2015; 17: 55–61. [in Russian]
5. Медведев В.Э. Предпосылки использования витаминных комплексов в адъювантной терапии психических расстройств. Лечащий врач. 2015; 9: 2–7. / Medvedev V.E. Predposylki ispol'zovaniia vitaminnykh kompleksov v ad"iuvantnoi terapii psikhicheskikh rasstroistv. Lechashchii vrach. 2015; 9: 2–7. [in Russian]
6. Пизова Н.В. Когнитивные нарушения при некоторых дисметаболических и дефицитарных состояниях. Consilium Medicum. 2015; 17 (9): 94–100. / Pizova N.V. Kognitivnye narusheniia pri nekotorykh dismetabolicheskikh i defitsitarnykh sostoianiiakh. Consilium Medicum. 2015; 17 (9): 94–100. [in Russian]
7. Kennedy DO, Veasey R, Watson A et al. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology (Berl) 2010; 211 (1): 55–68. DOI: 10.1007/s00213-010-1870-3.
8. Громова О.А. Магний и пиридоксин: основы знаний. М.: ПротоТип, 2006; с. 223. / Gromova O.A. Magnii i piridoksin: osnovy znanii. M.: ProtoTip, 2006; s. 223. [in Russian]
9. Акарачкова Е.С., Шавловская О.А., Вершинина С.В. и др. Роль дефицита магния в формировании клинических проявлений стресса у женщин. Проблемы женского здоровья. 2013; 8 (3): 52–9. / Akarachkova E.S., Shavlovskaia O.A., Vershinina S.V. i dr. Rol' defitsita magniia v formirovanii klinicheskikh proiavlenii stressa u zhenshchin. Problemy zhenskogo zdorov'ia. 2013; 8 (3): 52–9. [in Russian]
10. Stratone A, Stratone C, Chiruţă R et al. Ionic calcium and magnesium from pharmaceutical product BEROCCA effects on neuromuscular excitability. Rev Med Chir Soc Med Nat Iasi 2005; 109 (1): 200–5.
11. McGarel C, Pentieva K, Strain JJ et al. Emerging roles for folate and related B-vitamins in brain health across the lifecycle. Proc Nutr Soc 2015; 74 (1): 46–55. DOI: 10.1017/S0029665114001554.
12. Durga J, van Boxtel MPJ, Schouten EG et al. Effect of 3 year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007; 369 (9557): 208–16.
13. Scholey A, Bauer I, Neale C et al. Acute effects of different multivitamin mineral preparations with and without Guaraná on mood, cognitive performance and functional brain activation. Nutr 2013; 5 (9): 3589–604. DOI: 10.3390/nu5093589.
14. Haskell CF, Scholey AB, Jackson PA et al. Cognitive and mood effects in healthy children during 12 weeks supplementation with multi-vitamin/minerals. Br J Nutr 2008; 100: 1086–96.
15 Kennedy DO, Veasey RC, Watson AW. Vitamins and psychological functioning: a mobile phone assessment of the effects of a B vitamin complex, vitamin C and minerals on cognitive performance and subjective mood and energy. Hum Psychopharmacol 2011; 26 (4–5): 338–47. DOI: 10.1002/hup.1216.
16. Carroll D, Ring C, Suter M et al. The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: a double-blind placebo-controlled trial. Psychopharmacology (Berl) 2000; 150 (2): 220–5.
17. Schlebusch L, Bosch BA, Polglase G et al. A double-blind, placebo-controlled, double-centre study of the effects of an oral multivitamin-mineral combinatio non stress. S Afr Med J 2000; 90 (12): 1216–23.
18. Rucklidge JJ, Andridge R, Gorman B et al. Shaken but unstirred? Effects of micronutrients on stress and trauma after an earthquake: RCT evidence comparing formulas and doses. Hum Psychopharmacol 2012; 27 (5): 440–54. DOI: 10.1002/hup.2246.
2. Vakhnina N.V., Kalimeeva E.Iu. Primenenie vitaminno-mineral'nykh kompleksov v sostave nootropnoi terapii pri astenicheskikh sostoianiiakh i nevrologicheskikh rasstroistvakh. Med. sovet. 2015; 11: 12–16. [in Russian]
3. Pizova N.V. Kognitivnye narusheniia pri nekotorykh rasprostranennykh somaticheskikh zabolevaniiakh: kognitivnyi rezerv i terapevticheskie podkhody. Consilium Medicum. Neurology and Rheumatology (Suppl.). 2015; 2: 27–32. [in Russian]
4. Shavlovskaia O.A. Terapiia astenii i sviazannykh s nei sostoianii preparatami vitaminno-mineral'nogo kompleksa. Med. sovet. 2015; 17: 55–61. [in Russian]
5. Medvedev V.E. Predposylki ispol'zovaniia vitaminnykh kompleksov v ad"iuvantnoi terapii psikhicheskikh rasstroistv. Lechashchii vrach. 2015; 9: 2–7. [in Russian]
6. Pizova N.V. Kognitivnye narusheniia pri nekotorykh dismetabolicheskikh i defitsitarnykh sostoianiiakh. Consilium Medicum. 2015; 17 (9): 94–100. [in Russian]
7. Kennedy DO, Veasey R, Watson A et al. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology (Berl) 2010; 211 (1): 55–68. DOI: 10.1007/s00213-010-1870-3.
8. Gromova O.A. Magnii i piridoksin: osnovy znanii. M.: ProtoTip, 2006; s. 223. [in Russian]
9. Akarachkova E.S., Shavlovskaia O.A., Vershinina S.V. i dr. Rol' defitsita magniia v formirovanii klinicheskikh proiavlenii stressa u zhenshchin. Problemy zhenskogo zdorov'ia. 2013; 8 (3): 52–9. [in Russian]
10. Stratone A, Stratone C, Chiruţă R et al. Ionic calcium and magnesium from pharmaceutical product BEROCCA effects on neuromuscular excitability. Rev Med Chir Soc Med Nat Iasi 2005; 109 (1): 200–5.
11. McGarel C, Pentieva K, Strain JJ et al. Emerging roles for folate and related B-vitamins in brain health across the lifecycle. Proc Nutr Soc 2015; 74 (1): 46–55. DOI: 10.1017/S0029665114001554.
12. Durga J, van Boxtel MPJ, Schouten EG et al. Effect of 3 year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007; 369 (9557): 208–16.
13. Scholey A, Bauer I, Neale C et al. Acute effects of different multivitamin mineral preparations with and without Guaraná on mood, cognitive performance and functional brain activation. Nutr 2013; 5 (9): 3589–604. DOI: 10.3390/nu5093589.
14. Haskell CF, Scholey AB, Jackson PA et al. Cognitive and mood effects in healthy children during 12 weeks supplementation with multi-vitamin/minerals. Br J Nutr 2008; 100: 1086–96.
15 Kennedy DO, Veasey RC, Watson AW. Vitamins and psychological functioning: a mobile phone assessment of the effects of a B vitamin complex, vitamin C and minerals on cognitive performance and subjective mood and energy. Hum Psychopharmacol 2011; 26 (4–5): 338–47. DOI: 10.1002/hup.1216.
16. Carroll D, Ring C, Suter M et al. The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: a double-blind placebo-controlled trial. Psychopharmacology (Berl) 2000; 150 (2): 220–5.
17. Schlebusch L, Bosch BA, Polglase G et al. A double-blind, placebo-controlled, double-centre study of the effects of an oral multivitamin-mineral combinatio non stress. S Afr Med J 2000; 90 (12): 1216–23.
18. Rucklidge JJ, Andridge R, Gorman B et al. Shaken but unstirred? Effects of micronutrients on stress and trauma after an earthquake: RCT evidence comparing formulas and doses. Hum Psychopharmacol 2012; 27 (5): 440–54. DOI: 10.1002/hup.2246.
2. Вахнина Н.В., Калимеева Е.Ю. Применение витаминно-минеральных комплексов в составе ноотропной терапии при астенических состояниях и неврологических расстройствах. Мед. совет. 2015; 11: 12–16. / Vakhnina N.V., Kalimeeva E.Iu. Primenenie vitaminno-mineral'nykh kompleksov v sostave nootropnoi terapii pri astenicheskikh sostoianiiakh i nevrologicheskikh rasstroistvakh. Med. sovet. 2015; 11: 12–16. [in Russian]
3. Пизова Н.В. Когнитивные нарушения при некоторых распространенных соматических заболеваниях: когнитивный резерв и терапевтические подходы. Consilium Medicum. Неврология и Ревматология (Прил.). 2015; 2: 27–32. / Pizova N.V. Kognitivnye narusheniia pri nekotorykh rasprostranennykh somaticheskikh zabolevaniiakh: kognitivnyi rezerv i terapevticheskie podkhody. Consilium Medicum. Neurology and Rheumatology (Suppl.). 2015; 2: 27–32. [in Russian]
4. Шавловская О.А. Терапия астении и связанных с ней состояний препаратами витаминно-минерального комплекса. Мед. совет. 2015; 17: 55–61. / Shavlovskaia O.A. Terapiia astenii i sviazannykh s nei sostoianii preparatami vitaminno-mineral'nogo kompleksa. Med. sovet. 2015; 17: 55–61. [in Russian]
5. Медведев В.Э. Предпосылки использования витаминных комплексов в адъювантной терапии психических расстройств. Лечащий врач. 2015; 9: 2–7. / Medvedev V.E. Predposylki ispol'zovaniia vitaminnykh kompleksov v ad"iuvantnoi terapii psikhicheskikh rasstroistv. Lechashchii vrach. 2015; 9: 2–7. [in Russian]
6. Пизова Н.В. Когнитивные нарушения при некоторых дисметаболических и дефицитарных состояниях. Consilium Medicum. 2015; 17 (9): 94–100. / Pizova N.V. Kognitivnye narusheniia pri nekotorykh dismetabolicheskikh i defitsitarnykh sostoianiiakh. Consilium Medicum. 2015; 17 (9): 94–100. [in Russian]
7. Kennedy DO, Veasey R, Watson A et al. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology (Berl) 2010; 211 (1): 55–68. DOI: 10.1007/s00213-010-1870-3.
8. Громова О.А. Магний и пиридоксин: основы знаний. М.: ПротоТип, 2006; с. 223. / Gromova O.A. Magnii i piridoksin: osnovy znanii. M.: ProtoTip, 2006; s. 223. [in Russian]
9. Акарачкова Е.С., Шавловская О.А., Вершинина С.В. и др. Роль дефицита магния в формировании клинических проявлений стресса у женщин. Проблемы женского здоровья. 2013; 8 (3): 52–9. / Akarachkova E.S., Shavlovskaia O.A., Vershinina S.V. i dr. Rol' defitsita magniia v formirovanii klinicheskikh proiavlenii stressa u zhenshchin. Problemy zhenskogo zdorov'ia. 2013; 8 (3): 52–9. [in Russian]
10. Stratone A, Stratone C, Chiruţă R et al. Ionic calcium and magnesium from pharmaceutical product BEROCCA effects on neuromuscular excitability. Rev Med Chir Soc Med Nat Iasi 2005; 109 (1): 200–5.
11. McGarel C, Pentieva K, Strain JJ et al. Emerging roles for folate and related B-vitamins in brain health across the lifecycle. Proc Nutr Soc 2015; 74 (1): 46–55. DOI: 10.1017/S0029665114001554.
12. Durga J, van Boxtel MPJ, Schouten EG et al. Effect of 3 year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007; 369 (9557): 208–16.
13. Scholey A, Bauer I, Neale C et al. Acute effects of different multivitamin mineral preparations with and without Guaraná on mood, cognitive performance and functional brain activation. Nutr 2013; 5 (9): 3589–604. DOI: 10.3390/nu5093589.
14. Haskell CF, Scholey AB, Jackson PA et al. Cognitive and mood effects in healthy children during 12 weeks supplementation with multi-vitamin/minerals. Br J Nutr 2008; 100: 1086–96.
15 Kennedy DO, Veasey RC, Watson AW. Vitamins and psychological functioning: a mobile phone assessment of the effects of a B vitamin complex, vitamin C and minerals on cognitive performance and subjective mood and energy. Hum Psychopharmacol 2011; 26 (4–5): 338–47. DOI: 10.1002/hup.1216.
16. Carroll D, Ring C, Suter M et al. The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: a double-blind placebo-controlled trial. Psychopharmacology (Berl) 2000; 150 (2): 220–5.
17. Schlebusch L, Bosch BA, Polglase G et al. A double-blind, placebo-controlled, double-centre study of the effects of an oral multivitamin-mineral combinatio non stress. S Afr Med J 2000; 90 (12): 1216–23.
18. Rucklidge JJ, Andridge R, Gorman B et al. Shaken but unstirred? Effects of micronutrients on stress and trauma after an earthquake: RCT evidence comparing formulas and doses. Hum Psychopharmacol 2012; 27 (5): 440–54. DOI: 10.1002/hup.2246.
________________________________________________
2. Vakhnina N.V., Kalimeeva E.Iu. Primenenie vitaminno-mineral'nykh kompleksov v sostave nootropnoi terapii pri astenicheskikh sostoianiiakh i nevrologicheskikh rasstroistvakh. Med. sovet. 2015; 11: 12–16. [in Russian]
3. Pizova N.V. Kognitivnye narusheniia pri nekotorykh rasprostranennykh somaticheskikh zabolevaniiakh: kognitivnyi rezerv i terapevticheskie podkhody. Consilium Medicum. Neurology and Rheumatology (Suppl.). 2015; 2: 27–32. [in Russian]
4. Shavlovskaia O.A. Terapiia astenii i sviazannykh s nei sostoianii preparatami vitaminno-mineral'nogo kompleksa. Med. sovet. 2015; 17: 55–61. [in Russian]
5. Medvedev V.E. Predposylki ispol'zovaniia vitaminnykh kompleksov v ad"iuvantnoi terapii psikhicheskikh rasstroistv. Lechashchii vrach. 2015; 9: 2–7. [in Russian]
6. Pizova N.V. Kognitivnye narusheniia pri nekotorykh dismetabolicheskikh i defitsitarnykh sostoianiiakh. Consilium Medicum. 2015; 17 (9): 94–100. [in Russian]
7. Kennedy DO, Veasey R, Watson A et al. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology (Berl) 2010; 211 (1): 55–68. DOI: 10.1007/s00213-010-1870-3.
8. Gromova O.A. Magnii i piridoksin: osnovy znanii. M.: ProtoTip, 2006; s. 223. [in Russian]
9. Akarachkova E.S., Shavlovskaia O.A., Vershinina S.V. i dr. Rol' defitsita magniia v formirovanii klinicheskikh proiavlenii stressa u zhenshchin. Problemy zhenskogo zdorov'ia. 2013; 8 (3): 52–9. [in Russian]
10. Stratone A, Stratone C, Chiruţă R et al. Ionic calcium and magnesium from pharmaceutical product BEROCCA effects on neuromuscular excitability. Rev Med Chir Soc Med Nat Iasi 2005; 109 (1): 200–5.
11. McGarel C, Pentieva K, Strain JJ et al. Emerging roles for folate and related B-vitamins in brain health across the lifecycle. Proc Nutr Soc 2015; 74 (1): 46–55. DOI: 10.1017/S0029665114001554.
12. Durga J, van Boxtel MPJ, Schouten EG et al. Effect of 3 year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007; 369 (9557): 208–16.
13. Scholey A, Bauer I, Neale C et al. Acute effects of different multivitamin mineral preparations with and without Guaraná on mood, cognitive performance and functional brain activation. Nutr 2013; 5 (9): 3589–604. DOI: 10.3390/nu5093589.
14. Haskell CF, Scholey AB, Jackson PA et al. Cognitive and mood effects in healthy children during 12 weeks supplementation with multi-vitamin/minerals. Br J Nutr 2008; 100: 1086–96.
15 Kennedy DO, Veasey RC, Watson AW. Vitamins and psychological functioning: a mobile phone assessment of the effects of a B vitamin complex, vitamin C and minerals on cognitive performance and subjective mood and energy. Hum Psychopharmacol 2011; 26 (4–5): 338–47. DOI: 10.1002/hup.1216.
16. Carroll D, Ring C, Suter M et al. The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: a double-blind placebo-controlled trial. Psychopharmacology (Berl) 2000; 150 (2): 220–5.
17. Schlebusch L, Bosch BA, Polglase G et al. A double-blind, placebo-controlled, double-centre study of the effects of an oral multivitamin-mineral combinatio non stress. S Afr Med J 2000; 90 (12): 1216–23.
18. Rucklidge JJ, Andridge R, Gorman B et al. Shaken but unstirred? Effects of micronutrients on stress and trauma after an earthquake: RCT evidence comparing formulas and doses. Hum Psychopharmacol 2012; 27 (5): 440–54. DOI: 10.1002/hup.2246.
Авторы
О.А.Шавловская
ФГБОУ ВО Первый Московский государственный медицинский университет им. И.М.Сеченова Минздрава России. 119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2
shavlovskaya@1msmu.ru
I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation. 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2
shavlovskaya@1msmu.ru
ФГБОУ ВО Первый Московский государственный медицинский университет им. И.М.Сеченова Минздрава России. 119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2
shavlovskaya@1msmu.ru
________________________________________________
I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation. 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2
shavlovskaya@1msmu.ru
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