Патогенетическое обоснование включения таурина в лечение пациентов с сахарным диабетом типа 2

1. Wang J, Guo T. Metabolic remodeling in chronic heart failure. J Zhejiang Univ Sci B. 2013; 14 (8): 688–95.
2. Connor T, Martin SD, Howlet KF, McGee SL. Metabolic remodelling in obesity and type 2 diabetes: pathological or protective mechanisms in response to nutrient excess? Clin Exp Pharmacol Physiol 2015; 42 (1): 109–15.
3. Hollinshead Kate ER, Tennant DA. Mitochondrial metabolic remodeling in response to genetic and environmental perturbations. WIREs Syst Biol Med 2016, 8: 272–85.
4. Lambert IH, Kristensen DM, Holm JB, Mortensen OH. Physiological role of taurine – from organism to organelle. Acta Physiol 2015; 213: 191–212.
5. Xu Y-J, Arneja AS, Tappia PS, Dhalla NS. The potential health benefits of taurine in cardiovascular disease. Exp Clin Cardiol 2008; 13 (2): 57–65.
6. Maturo J, Kulakowski EC. Taurine binding to the puri ed insulin receptor. Biochem Pharmacol 1988; 37 (19): 3755–60.
7. Carneiro EM, Latorraca MQ, Araujo E et al. Taurine supplementation modulates glucose homeostasis and islet function. J Nutr Biochem 2009; 20 (7): 503–11.
8. Xiao C, Giacca A, Lewis GF. Oral taurine but not N-acetylcysteine ameliorates NEFA-induced impairment in insulin sensitivity and beta cell function in obese and overweight, non-diabetic men. Diabetologia 2008; 51 (1): 139–46.
9. Yokogoshi H, Mochizuki H, Nanami K et al. Dietary taurine enhances cholesterol degradation and reduces serum and liver cholesterol concentrations in rats fed a high-cholesterol diet. J Nutr 1999; 129: 1705–12.
10. Murakami S, Yamagishi I, Asami Y et al. Hypolipidemic effect of taurine in stroke-prone spontaneously hypertensive rats. Pharmacology 1996; 52: 303–13.
11. Wen Chen Junxia Guo, Yanzhen Zhangan, Jing Zhang. The beneficial effects of taurine in preventing metabolic syndrome. Food Funct 2016; 7: 1849–63.
12. De la Puerta C, Arrieta FJ, Balsa JA et al. Taurine and glucose metabolism: a review. Nutr Hosp 2010; 25 (6): 910–9.
13. Imae M, Asano T, Murakami S. Potential role of taurine in the prevention of diabetes and metabolic syndrome. Amino Acids 2014; 46 (1): 81–8.
14. Wu N, Lu Y, He B et al. Taurine prevents free fatty acid-induced hepatic insulin resistance in association with inhibiting JNK1 activation and improving insulin signaling in vivo. Diabetes Res ClinPract 2010; 90: 288–96.
15. Park EJ, Bae JH, Kim SY et al. Inhibition of ATP-sensitive K+ channels by taurine through a benzamido- binding site on sulfonylurea receptor 1. Biochem Pharmacol 2004; 67: 1089–96.
16. Jong CJ, Azuma J, Schaffer S. Mechanism underlying the antioxidant activity of taurine: prevention of mitochondrial oxidant production. Amino Acids 2012; 42: 2223–32.
17. Liu Y, Quinn MR. Chemokine production by rat alveolar macrophages is inhibited by taurine chloramine. Immunol Lett 2002; 80: 27–32.
18. Tsuboyama-Kasaoka N, Shozawa C, Sano K et al. Taurine (2-aminoethanesulfonic acid) deficiency creates a vicious circle promoting obesity. Endocrinology 2006; 147: 3276–84.
19. Yokogoshi H, Mochizuki H, Nanami K et al. Dietary taurine enhances cholesterol degradation and reduces serum and liver cholesterol concentrations in rats fed a high-cholesterol diet. J Nutr 1999; 129: 1705–12.
20. Murakami S, Kondo Y, Toda Y et al. Effect of taurine on cholesterol metabolism in hamsters: up-regulation of low density lipoprotein (LDL) receptor by taurine. Life Sci 2002; 70: 2355–66.
21. Yamamoto K, Yoshitama A, Sakono M et al. Dietary taurine decreases hepatic secretion of cholesterol ester in rats fed a high-cholesterol diet. Pharmacology 2000; 60: 27–33.
22. Yanagita T, Han SY, Hu Y et al. Taurine reduces the secretion of apolipoprotein B100 and lipids in HepG2 cells. Lipids Health Dis 2008; 7: 38.
23. Nishimura N, Yamamoto T, Ota T. Taurine feeding inhibits bile acid absorption from the ileum in rats fed a high cholesterol and high fat diet. Adv Exp Med Biol 2009; 643: 285–91.
24. Takahashi K, Azuma M, Taira K. et al. Effect of taurine on angiotensin II-induced hypertrophy of neonatal rat cardiac cells. J Cardiovasc Pharmacol 1997; 30: 725–30.
25. Azuma M, Takahashi K, Fukuda T et al. Taurine attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac myocytes. Eur J Pharmacol 2000; 403: 181–8.
26. Ideishi M, Miura S, Sakai T et al. Taurine amplifies renal kallikrein and prevents saltinduced hypertension in Dahl rats. J Hypertens 1994; 12: 653–61.
27. Mizushima S, Nara Y, Sawamura M, Yamori Y. Effects of oral taurine supplementation on lipids and sympathetic nerve tone. Adv Exp Med Biol 1996; 403: 615–22.
28. Mozaffari MS, Abdelsayed R, Patel C, Schaffer SW. Effects of dietary salt and fat on taurine excretion in healthy and diseased rats. Adv Exp Med Biol 2006; 583: 173–180.
29. Niu LG, Zhang MS, Liu Y et al. Vasorelaxant effect of taurine is diminished by tetraethylammonium in rat isolated arteries. Eur J Pharmacol 2008; 580: 169–74.
30. Аметов А.С., Кочергина И.И. Применение Дибикора при сахарном диабете и сердечно-сосудистой патологии. Эффективная фармакотерапия в эндокринологии. 2007; 2: 40–9. / Ametov A.S., Kochergina I.I. Primenenie Dibikora pri sakharnom diabete i serdechno-sosudistoi patologii. Effektivnaia farmakoterapiia v endokrinologii. 2007; 2: 40–9. [in Russian]
31. Кочергина И.И., Доскина Е.В., Аметов А.С. Лантус и Дибикор в лечении сахарного диабета 2-го типа. Ремедиум. Приволжье. 2010; с. 30–1. / Kochergina I.I., Doskina E.V., Ametov A.S. Lantus i Dibikor v lechenii sakharnogo diabeta 2-go tipa. Remedium. Privolzh'e. 2010; s. 30–1. [in Russian]
32. Петров В.И., Наумов В.В. Опыт применения таурина при лечении больных сахарным диабетом типа 2. Эндокринология: новости, мнения, обучение. 2014; 1: 44–53. / Petrov V.I., Naumov V.V. Opyt primeneniia taurina pri lechenii bol'nykh sakharnym diabetom tipa 2. Endokrinologiia: novosti, mneniia, obuchenie. 2014; 1: 44–53. [in Russian]
33. Tricarico D, Barbieri M, Camerino DC. Taurine blocks ATP sensitive potassium channels of rat skeletal muscle fibres interfering with the sulphonylurea receptor. Br J Pharmacol 2000; 130: 827–84.
34. Нечаева Г.И., Друк И.В., Ряполова Е.А. Эффективность и переносимость таурина у пациентов с СД 2-го типа и диастолической дисфункцией левого желудочка. Лечащий врач. 2011; 11: 1–5. / Nechaeva G.I., Druk I.V., Riapolova E.A. Effektivnost' i perenosimost' taurina u patsientov s SD 2-go tipa i diastolicheskoi disfunktsiei levogo zheludochka. Lechashchii vrach. 2011; 11: 1–5. [in Russian]
35. Стаценко М.Е., Винникова А.А., Шилина Н.Н., Ронская А.М. Возможности Дибикора в коррекции метаболических и сосудистых нарушений у больных хронической сердечной недостаточностью и сахарным диабетом 2 типа. Фарматека. 2014; 4: 33–40. / Statsenko M.E., Vinnikova A.A., Shilina N.N., Ronskaia A.M. Vozmozhnosti Dibikora v korrektsii metabolicheskikh i sosudistykh narushenii u bol'nykh khronicheskoi serdechnoi nedostatochnost'iu i sakharnym diabetom 2 tipa. Farmateka. 2014; 4: 33–40. [in Russian]
36. Стаценко М.Е., Туркина С.В., Шилина Н.Н., Винникова А.А. Дополнительные возможности таурина в комплексной терапии больных сахарным диабетом типа 2, страдающих хронической сердечной недостаточностью. Эндокринология: новости, мнения, обучение. 2015; 1: 52–6. / Statsenko M.E., Turkina S.V., Shilina N.N., Vinnikova A.A. Dopolnitel'nye vozmozhnosti taurina v kompleksnoi terapii bol'nykh sakharnym diabetom tipa 2, stradaiushchikh khronicheskoi serdechnoi nedostatochnost'iu. Endokrinologiia: novosti, mneniia, obuchenie. 2015; 1: 52–6. [in Russian]
37. Pansani MC, Azevedo PS, Rafacho BPM et al. Atrophic Cardiac Remodeling Induced by Taurine Deficiency in Wistar Rats. PLoS ONE 2012; 7 (7): e41439. DOI: 10.1371/journal.pone.0041439.
38. Ito T, Yoshikawa N, Schaffer SW, Azuma J. Tissue Taurine Depletion Alters Metabolic Response to Exercise and Reduces Running Capacity in Mice. J Amino Acids 2014; 2014: Article ID 964680, 10 pages.
39. Li C, Cao L, Zeng Q et al. Taurine may prevent diabetic rats from developing cardiomyopathy also by downregulating angiotensin II type2 receptor expression. Cardiovasc Drug Ther 2005; 19 (2): 105–12.
40. Schaffer SW, Jong CJ, Ramila KC, Azuma J. Physiological roles of taurine in heart and muscle. J Biomed Sci 2010; 17 (Suppl. 1): S2.
41. Гордеев И.Г, Покровская Е.М, Лучинкина Е.Е. Влияние таурина на частоту распространения нарушений сердечного ритма, дисперсию интервала QT у пациентов c сердечной недостаточностью вследствие постинфарктного кардиосклероза: результаты сравнительного, рандомизированного исследования. Кардиоваскулярная терапия и профилактика. 2012; 11 (1): 65–70. / Gordeev I.G, Pokrovskaia E.M, Luchinkina E.E. Vliianie taurina na chastotu rasprostraneniia narushenii serdechnogo ritma, dispersiiu intervala QT u patsientov c serdechnoi nedostatochnost'iu vsledstvie postinfarktnogo kardioskleroza: rezul'taty sravnitel'nogo, randomizirovannogo issledovaniia. Kardiovaskuliarnaia terapiia i profilaktika. 2012; 11 (1): 65–70. [in Russian]
42. Wang LJ, Yu YH, Zhang LG et al. Taurine rescues vascular endothelial dysfunction in streptozocin-induced diabetic rats: correlated with downregulation of LOX-1 and ICAM-1 expression on aortas. Eur J Pharmacol 2008; 597: 75–80.
43. Ulrich-Merzenich G, Zeitler H, Vetter H, Bhonde RR. Protective effects of taurine on endothelial cells impaired by high glucose and oxidized low-density lipoproteins. Eur J Nutr 2007; 46: 431–8.
44. Стаценко М.Е., Туркина С.В., Шилина Н.Н., Винникова А.А. Эндотелиотропные свойства таурина у больных с хронической сердечной недостаточностью и сахарным диабетом 2 типа. Кардиоваскулярная терапия и профилактика. 2016; 15 (2): 38–44. / Statsenko M.E., Turkina S.V., Shilina N.N., Vinnikova A.A. Endoteliotropnye svoistva taurina u bol'nykh s khronicheskoi serdechnoi nedostatochnost'iu i sakharnym diabetom 2 tipa. Kardiovaskuliarnaia terapiia i profilaktika. 2016; 15 (2): 38–44. [in Russian]
45. Стаценко М.Е., Винникова А.А., Ронская А.М., Шилина Н.Н. Таурин в терапии хронической сердечной недостаточности и сахарного диабета 2 типа: влияние на микроциркуляцию и эластические свойства магистральных сосудов. Сердечная Недостаточность. 2013; 14 (6): 347–53. / Statsenko M.E., Vinnikova A.A., Ronskaia A.M., Shilina N.N. Taurin v terapii khronicheskoi serdechnoi nedostatochnosti i sakharnogo diabeta 2 tipa: vliianie na mikrotsirkuliatsiiu i elasticheskie svoistva magistral'nykh sosudov. Serdechnaia Nedostatochnost'. 2013; 14 (6): 347–53. [in Russian]
46. Abebe W, Mozaffari MS. Role of taurine in the vasculature: an overview of experimental and human studies. Am J Cardiovasc Dis 2011; 1 (3): 293–311.
47. Satoh H, Kang J. Modulation by taurine of human arterial stiffness and wave reflection. Adv Exp Med Biol 2009; 643: 47–55.
48. El Idrissi A, Okeke E, Yan X et al. Taurine regulation of blood pressure and vasoactivity. Adv Exp Med Biol 2013; 775: 407–25.
49. Адамчик А.С., Крючкова И.В. Возможности коррекции нарушений углеводного обмена и суточного профиля артериального давления у пациентов с хронической сердечной недостаточностью и метаболическим синдромом. Фарматека. 2009; 15: 81–5. / Adamchik A.S., Kriuchkova I.V. Vozmozhnosti korrektsii narushenii uglevodnogo obmena i sutochnogo profilia arterial'nogo davleniia u patsientov s khronicheskoi serdechnoi nedostatochnost'iu i metabolicheskim sindromom. Farmateka. 2009; 15: 81–5. [in Russian]
50. Higo S, Miyata S, Jiang QY et al. Taurine administration after appearance of proteinuria retards progression of diabetic nephropathy in rats. Kobe J Med Sci 2008; 54 (1): E35–45.
51. Shumei Lin, Jiancheng Yang, Gaofeng Wu et al. Preventive effect of taurine on experimental type II diabetic nephropathy. J Biomed Sci 2010; 17 (Suppl. 1): S46–54.
52. Huang JS, Chuang LY, Guh JY et al. Antioxidants attenuate high glucose-induced hypertrophic growth in renal tubular epithelial cells. Am J Physiol Renal Physiol 2007; 293: F1072–F1082.
53. Huang JS, Chuang LY, Guh JY et al. Effect of taurine on advanced glycation end products-induced hypertrophy in renal tubular epithelial cells. Toxicol Appl Pharmacol 2008; 233 (2): 220–6.
54. Huang JS, Chuang LY, Guh JY, Huang YJ. Effects of nitric oxide and antioxidants on advanced glycation end products-induced hypertrophic growth in human renal tubular cells. Toxicol Sci 2009; 111 (1): 109–19.
55. Mozaffari MS, Miyata N, Schaffer SW. Effects of taurine and enalapril on kidney function of the hypertensive glucoseintolerant rat. Am J Hypertens 2003; 16: 673–80.
56. Стаценко М.Е., Туркина С.В., Шилина Н.Н. Поражение печени у больных с хронической сердечной недостаточностью ишемического генеза и сахарным диабетом типа 2 – коварный тандем: возможности дополнительной органопротективной терапии. Consilium Medicum. 2016; 18 (5): 103–9. / Statsenko M.E., Turkina S.V., Shilina N.N. Porazhenie pecheni u bol'nykh s khronicheskoi serdechnoi nedostatochnost'iu ishemicheskogo geneza i sakharnym diabetom tipa 2 – kovarnyi tandem: vozmozhnosti dopolnitel'noi organoprotektivnoi terapii. Consilium Medicum. 2016; 18 (5): 103–9. [in Russian]
57. Hu J, Xu X, Yang J et al. Antihypertensive effect of taurine in rat. Adv Exp Med Biol 2009; 643: 75–84.
58. Winiarska K, Szymanski K, Gorniak P et al. Hypoglycaemic, antioxidative and nephroprotective effects of taurine in alloxan diabetic rabbits. Biochimie 2009; 91 (2): 261–70.
59. Gentile CL, Nivala AM et al. Experimental evidence for therapeutic potential of taurine in the treatment of nonalcoholic fatty liver disease. Am J Physiol Regul Integr Comp Physiol 2011; 301 (6): R1710–R1722.
60. Овсянникова О.Н., Звенигородская Л.А. Целесообразность применения таурина в лечении неалкогольной жировой болезни печени. Эффективная фармакотерапия. Гастроэнтерология. 2012; 2: 34–9. / Ovsiannikova O.N., Zvenigorodskaia L.A. Tselesoobraznost' primeneniia taurina v lechenii nealkogol'noi zhirovoi bolezni pecheni. Effektivnaia farmakoterapiia. Gastroenterologiia. 2012; 2: 34–9. [in Russian]
61. Лосева Н.В., Моисеенко Е.Е. Опыт применения препарата Дибикор в комплексной терапии неалкогольной жировой болезни печени. Фарматека. 2010; 13: 63–7. / Loseva N.V., Moiseenko E.E. Opyt primeneniia preparata Dibikor v kompleksnoi terapii nealkogol'noi zhirovoi bolezni pecheni. Farmateka. 2010; 13: 63–7. [in Russian]
62. Шестакова М.В., Чугунова Л.А., Шамхалова М.Ш. Опыт применения Дибикора при сахарном диабете 2 типа. Сахарный диабет. 2007; 1. / Shestakova M.V., Chugunova L.A., Shamkhalova M.Sh. Opyt primeneniia Dibikora pri sakharnom diabete 2 tipa. Sakharnyi diabet. 2007; 1. [in Russian]
63. Аметов А.С., Кочергина И.И., Елизарова Е.П. Опыт применения Дибикора при сахарном диабете 2 типа. Проблемы эндокринологии. 2007; 53 (4): 18–23. / Ametov A.S., Kochergina I.I., Elizarova E.P. Opyt primeneniia Dibikora pri sakharnom diabete 2 tipa. Problemy endokrinologii. 2007; 53 (4): 18–23. [in Russian]
64. Кудинов В.И., Золотарева Н.В., Шульга Ю.В. Изучение клинической эффективности Дибикора при сахарном диабете II типа. Главный врач. Фармация. 2007; 1 (9): 17–9. / Kudinov V.I., Zolotareva N.V., Shul'ga Iu.V. Izuchenie klinicheskoi effektivnosti Dibikora pri sakharnom diabete II tipa. Glavnyi vrach. Farmatsiia. 2007; 1 (9): 17–9. [in Russian]
65. Мкртумян А.М., Подачина С.В., Петраченко В.В. Дибикор – эффективное и безопасное средство для лечения сахарного диабета. Эффективная фармакотерапия в эндокринологии. 2008; 2: 34–9. / Mkrtumian A.M., Podachina S.V., Petrachenko V.V. Dibikor – effektivnoe i bezopasnoe sredstvo dlia lecheniia sakharnogo diabeta. Effektivnaia farmakoterapiia v endokrinologii. 2008; 2: 34–9. [in Russian]
66. Недосугова Л.В. Место Дибикора в комплексной терапии сахарного диабета (литературный обзор). Фарматека. 2008; 17: 22–7. / Nedosugova L.V. Mesto Dibikora v kompleksnoi terapii sakharnogo diabeta (literaturnyi obzor). Farmateka. 2008; 17: 22–7. [in Russian]
67. Бондарь И.А., Шабельникова О.Ю., Алина А.Р. Антиоксидант Дибикор в лечении сосудистых осложнений сахарного диабета 2 типа. Проблемы эндокринологии. 2009; 55 (2): 41–5. / Bondar' I.A., Shabel'nikova O.Iu., Alina A.R. Antioksidant Dibikor v lechenii sosudistykh oslozhnenii sakharnogo diabeta 2 tipa. Problemy endokrinologii. 2009; 55 (2): 41–5. [in Russian]
68. Ворохобина Н.В., Кузнецова А.В. Применение Дибикора у больных сахарным диабетом 2 типа и метаболическим синдромом. РМЖ. Эндокринология. 2010; 118 (30): 1816–9. / Vorokhobina N.V., Kuznetsova A.V. Primenenie Dibikora u bol'nykh sakharnym diabetom 2 tipa i metabolicheskim sindromom. RMZh. Endokrinologiia. 2010; 118 (30): 1816–9. [in Russian]
69. Северина Т.И., Попкова Е.Н., Трельская Н.Ю., Емельянов В.В. Клиническая и метаболическая эффективность препарата Дибикор у больных сахарным диабетом 2 типа. Фарматека. 2011; 5: 126–9. / Severina T.I., Popkova E.N., Trel'skaia N.Iu., Emel'ianov V.V. Klinicheskaia i metabolicheskaia effektivnost' preparata Dibikor u bol'nykh sakharnym diabetom 2 tipa. Farmateka. 2011; 5: 126–9. [in Russian]
70. Перцева Т.А., Перцева Н.О., Мищенко Н.А., Братусь Е.В. Новые возможности метаболической терапии у пациентов с сахарным диабетом 1 и 2 типов. Медичнi перспективи. 2011; XVI/2: 1–7. / Pertseva T.A., Pertseva N.O., Mishchenko N.A., Bratus' E.V. Novye vozmozhnosti metabolicheskoi terapii u patsientov s sakharnym diabetom 1 i 2 tipov. Medichni perspektivi. 2011; XVI/2: 1–7. [in Russian]
71. Мановицкая А.В. Метаболическая терапия у пациентов с метаболическим синдромом. Поликлиника. 2012; 2/1: 25–8. / Manovitskaia A.V. Metabolicheskaia terapiia u patsientov s metabolicheskim sindromom. Poliklinika. 2012; 2/1: 25–8. [in Russian]

________________________________________________

1. Wang J, Guo T. Metabolic remodeling in chronic heart failure. J Zhejiang Univ Sci B. 2013; 14 (8): 688–95.
2. Connor T, Martin SD, Howlet KF, McGee SL. Metabolic remodelling in obesity and type 2 diabetes: pathological or protective mechanisms in response to nutrient excess? Clin Exp Pharmacol Physiol 2015; 42 (1): 109–15.
3. Hollinshead Kate ER, Tennant DA. Mitochondrial metabolic remodeling in response to genetic and environmental perturbations. WIREs Syst Biol Med 2016, 8: 272–85.
4. Lambert IH, Kristensen DM, Holm JB, Mortensen OH. Physiological role of taurine – from organism to organelle. Acta Physiol 2015; 213: 191–212.
5. Xu Y-J, Arneja AS, Tappia PS, Dhalla NS. The potential health benefits of taurine in cardiovascular disease. Exp Clin Cardiol 2008; 13 (2): 57–65.
6. Maturo J, Kulakowski EC. Taurine binding to the puri ed insulin receptor. Biochem Pharmacol 1988; 37 (19): 3755–60.
7. Carneiro EM, Latorraca MQ, Araujo E et al. Taurine supplementation modulates glucose homeostasis and islet function. J Nutr Biochem 2009; 20 (7): 503–11.
8. Xiao C, Giacca A, Lewis GF. Oral taurine but not N-acetylcysteine ameliorates NEFA-induced impairment in insulin sensitivity and beta cell function in obese and overweight, non-diabetic men. Diabetologia 2008; 51 (1): 139–46.
9. Yokogoshi H, Mochizuki H, Nanami K et al. Dietary taurine enhances cholesterol degradation and reduces serum and liver cholesterol concentrations in rats fed a high-cholesterol diet. J Nutr 1999; 129: 1705–12.
10. Murakami S, Yamagishi I, Asami Y et al. Hypolipidemic effect of taurine in stroke-prone spontaneously hypertensive rats. Pharmacology 1996; 52: 303–13.
11. Wen Chen Junxia Guo, Yanzhen Zhangan, Jing Zhang. The beneficial effects of taurine in preventing metabolic syndrome. Food Funct 2016; 7: 1849–63.
12. De la Puerta C, Arrieta FJ, Balsa JA et al. Taurine and glucose metabolism: a review. Nutr Hosp 2010; 25 (6): 910–9.
13. Imae M, Asano T, Murakami S. Potential role of taurine in the prevention of diabetes and metabolic syndrome. Amino Acids 2014; 46 (1): 81–8.
14. Wu N, Lu Y, He B et al. Taurine prevents free fatty acid-induced hepatic insulin resistance in association with inhibiting JNK1 activation and improving insulin signaling in vivo. Diabetes Res ClinPract 2010; 90: 288–96.
15. Park EJ, Bae JH, Kim SY et al. Inhibition of ATP-sensitive K+ channels by taurine through a benzamido- binding site on sulfonylurea receptor 1. Biochem Pharmacol 2004; 67: 1089–96.
16. Jong CJ, Azuma J, Schaffer S. Mechanism underlying the antioxidant activity of taurine: prevention of mitochondrial oxidant production. Amino Acids 2012; 42: 2223–32.
17. Liu Y, Quinn MR. Chemokine production by rat alveolar macrophages is inhibited by taurine chloramine. Immunol Lett 2002; 80: 27–32.
18. Tsuboyama-Kasaoka N, Shozawa C, Sano K et al. Taurine (2-aminoethanesulfonic acid) deficiency creates a vicious circle promoting obesity. Endocrinology 2006; 147: 3276–84.
19. Yokogoshi H, Mochizuki H, Nanami K et al. Dietary taurine enhances cholesterol degradation and reduces serum and liver cholesterol concentrations in rats fed a high-cholesterol diet. J Nutr 1999; 129: 1705–12.
20. Murakami S, Kondo Y, Toda Y et al. Effect of taurine on cholesterol metabolism in hamsters: up-regulation of low density lipoprotein (LDL) receptor by taurine. Life Sci 2002; 70: 2355–66.
21. Yamamoto K, Yoshitama A, Sakono M et al. Dietary taurine decreases hepatic secretion of cholesterol ester in rats fed a high-cholesterol diet. Pharmacology 2000; 60: 27–33.
22. Yanagita T, Han SY, Hu Y et al. Taurine reduces the secretion of apolipoprotein B100 and lipids in HepG2 cells. Lipids Health Dis 2008; 7: 38.
23. Nishimura N, Yamamoto T, Ota T. Taurine feeding inhibits bile acid absorption from the ileum in rats fed a high cholesterol and high fat diet. Adv Exp Med Biol 2009; 643: 285–91.
24. Takahashi K, Azuma M, Taira K. et al. Effect of taurine on angiotensin II-induced hypertrophy of neonatal rat cardiac cells. J Cardiovasc Pharmacol 1997; 30: 725–30.
25. Azuma M, Takahashi K, Fukuda T et al. Taurine attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac myocytes. Eur J Pharmacol 2000; 403: 181–8.
26. Ideishi M, Miura S, Sakai T et al. Taurine amplifies renal kallikrein and prevents saltinduced hypertension in Dahl rats. J Hypertens 1994; 12: 653–61.
27. Mizushima S, Nara Y, Sawamura M, Yamori Y. Effects of oral taurine supplementation on lipids and sympathetic nerve tone. Adv Exp Med Biol 1996; 403: 615–22.
28. Mozaffari MS, Abdelsayed R, Patel C, Schaffer SW. Effects of dietary salt and fat on taurine excretion in healthy and diseased rats. Adv Exp Med Biol 2006; 583: 173–180.
29. Niu LG, Zhang MS, Liu Y et al. Vasorelaxant effect of taurine is diminished by tetraethylammonium in rat isolated arteries. Eur J Pharmacol 2008; 580: 169–74.
30. Ametov A.S., Kochergina I.I. Primenenie Dibikora pri sakharnom diabete i serdechno-sosudistoi patologii. Effektivnaia farmakoterapiia v endokrinologii. 2007; 2: 40–9. [in Russian]
31. Kochergina I.I., Doskina E.V., Ametov A.S. Lantus i Dibikor v lechenii sakharnogo diabeta 2-go tipa. Remedium. Privolzh'e. 2010; s. 30–1. [in Russian]
32. Petrov V.I., Naumov V.V. Opyt primeneniia taurina pri lechenii bol'nykh sakharnym diabetom tipa 2. Endokrinologiia: novosti, mneniia, obuchenie. 2014; 1: 44–53. [in Russian]
33. Tricarico D, Barbieri M, Camerino DC. Taurine blocks ATP sensitive potassium channels of rat skeletal muscle fibres interfering with the sulphonylurea receptor. Br J Pharmacol 2000; 130: 827–84.
34. Nechaeva G.I., Druk I.V., Riapolova E.A. Effektivnost' i perenosimost' taurina u patsientov s SD 2-go tipa i diastolicheskoi disfunktsiei levogo zheludochka. Lechashchii vrach. 2011; 11: 1–5. [in Russian]
35. Statsenko M.E., Vinnikova A.A., Shilina N.N., Ronskaia A.M. Vozmozhnosti Dibikora v korrektsii metabolicheskikh i sosudistykh narushenii u bol'nykh khronicheskoi serdechnoi nedostatochnost'iu i sakharnym diabetom 2 tipa. Farmateka. 2014; 4: 33–40. [in Russian]
36. Statsenko M.E., Turkina S.V., Shilina N.N., Vinnikova A.A. Dopolnitel'nye vozmozhnosti taurina v kompleksnoi terapii bol'nykh sakharnym diabetom tipa 2, stradaiushchikh khronicheskoi serdechnoi nedostatochnost'iu. Endokrinologiia: novosti, mneniia, obuchenie. 2015; 1: 52–6. [in Russian]
37. Pansani MC, Azevedo PS, Rafacho BPM et al. Atrophic Cardiac Remodeling Induced by Taurine Deficiency in Wistar Rats. PLoS ONE 2012; 7 (7): e41439. DOI: 10.1371/journal.pone.0041439.
38. Ito T, Yoshikawa N, Schaffer SW, Azuma J. Tissue Taurine Depletion Alters Metabolic Response to Exercise and Reduces Running Capacity in Mice. J Amino Acids 2014; 2014: Article ID 964680, 10 pages.
39. Li C, Cao L, Zeng Q et al. Taurine may prevent diabetic rats from developing cardiomyopathy also by downregulating angiotensin II type2 receptor expression. Cardiovasc Drug Ther 2005; 19 (2): 105–12.
40. Schaffer SW, Jong CJ, Ramila KC, Azuma J. Physiological roles of taurine in heart and muscle. J Biomed Sci 2010; 17 (Suppl. 1): S2.
41. Gordeev I.G, Pokrovskaia E.M, Luchinkina E.E. Vliianie taurina na chastotu rasprostraneniia narushenii serdechnogo ritma, dispersiiu intervala QT u patsientov c serdechnoi nedostatochnost'iu vsledstvie postinfarktnogo kardioskleroza: rezul'taty sravnitel'nogo, randomizirovannogo issledovaniia. Kardiovaskuliarnaia terapiia i profilaktika. 2012; 11 (1): 65–70. [in Russian]
42. Wang LJ, Yu YH, Zhang LG et al. Taurine rescues vascular endothelial dysfunction in streptozocin-induced diabetic rats: correlated with downregulation of LOX-1 and ICAM-1 expression on aortas. Eur J Pharmacol 2008; 597: 75–80.
43. Ulrich-Merzenich G, Zeitler H, Vetter H, Bhonde RR. Protective effects of taurine on endothelial cells impaired by high glucose and oxidized low-density lipoproteins. Eur J Nutr 2007; 46: 431–8.
44. Statsenko M.E., Turkina S.V., Shilina N.N., Vinnikova A.A. Endoteliotropnye svoistva taurina u bol'nykh s khronicheskoi serdechnoi nedostatochnost'iu i sakharnym diabetom 2 tipa. Kardiovaskuliarnaia terapiia i profilaktika. 2016; 15 (2): 38–44. [in Russian]
45. Statsenko M.E., Vinnikova A.A., Ronskaia A.M., Shilina N.N. Taurin v terapii khronicheskoi serdechnoi nedostatochnosti i sakharnogo diabeta 2 tipa: vliianie na mikrotsirkuliatsiiu i elasticheskie svoistva magistral'nykh sosudov. Serdechnaia Nedostatochnost'. 2013; 14 (6): 347–53. [in Russian]
46. Abebe W, Mozaffari MS. Role of taurine in the vasculature: an overview of experimental and human studies. Am J Cardiovasc Dis 2011; 1 (3): 293–311.
47. Satoh H, Kang J. Modulation by taurine of human arterial stiffness and wave reflection. Adv Exp Med Biol 2009; 643: 47–55.
48. El Idrissi A, Okeke E, Yan X et al. Taurine regulation of blood pressure and vasoactivity. Adv Exp Med Biol 2013; 775: 407–25.
49. Adamchik A.S., Kriuchkova I.V. Vozmozhnosti korrektsii narushenii uglevodnogo obmena i sutochnogo profilia arterial'nogo davleniia u patsientov s khronicheskoi serdechnoi nedostatochnost'iu i metabolicheskim sindromom. Farmateka. 2009; 15: 81–5. [in Russian]
50. Higo S, Miyata S, Jiang QY et al. Taurine administration after appearance of proteinuria retards progression of diabetic nephropathy in rats. Kobe J Med Sci 2008; 54 (1): E35–45.
51. Shumei Lin, Jiancheng Yang, Gaofeng Wu et al. Preventive effect of taurine on experimental type II diabetic nephropathy. J Biomed Sci 2010; 17 (Suppl. 1): S46–54.
52. Huang JS, Chuang LY, Guh JY et al. Antioxidants attenuate high glucose-induced hypertrophic growth in renal tubular epithelial cells. Am J Physiol Renal Physiol 2007; 293: F1072–F1082.
53. Huang JS, Chuang LY, Guh JY et al. Effect of taurine on advanced glycation end products-induced hypertrophy in renal tubular epithelial cells. Toxicol Appl Pharmacol 2008; 233 (2): 220–6.
54. Huang JS, Chuang LY, Guh JY, Huang YJ. Effects of nitric oxide and antioxidants on advanced glycation end products-induced hypertrophic growth in human renal tubular cells. Toxicol Sci 2009; 111 (1): 109–19.
55. Mozaffari MS, Miyata N, Schaffer SW. Effects of taurine and enalapril on kidney function of the hypertensive glucoseintolerant rat. Am J Hypertens 2003; 16: 673–80.
56. Statsenko M.E., Turkina S.V., Shilina N.N. Porazhenie pecheni u bol'nykh s khronicheskoi serdechnoi nedostatochnost'iu ishemicheskogo geneza i sakharnym diabetom tipa 2 – kovarnyi tandem: vozmozhnosti dopolnitel'noi organoprotektivnoi terapii. Consilium Medicum. 2016; 18 (5): 103–9. [in Russian]
57. Hu J, Xu X, Yang J et al. Antihypertensive effect of taurine in rat. Adv Exp Med Biol 2009; 643: 75–84.
58. Winiarska K, Szymanski K, Gorniak P et al. Hypoglycaemic, antioxidative and nephroprotective effects of taurine in alloxan diabetic rabbits. Biochimie 2009; 91 (2): 261–70.
59. Gentile CL, Nivala AM et al. Experimental evidence for therapeutic potential of taurine in the treatment of nonalcoholic fatty liver disease. Am J Physiol Regul Integr Comp Physiol 2011; 301 (6): R1710–R1722.
60. Ovsiannikova O.N., Zvenigorodskaia L.A. Tselesoobraznost' primeneniia taurina v lechenii nealkogol'noi zhirovoi bolezni pecheni. Effektivnaia farmakoterapiia. Gastroenterologiia. 2012; 2: 34–9. [in Russian]
61. Loseva N.V., Moiseenko E.E. Opyt primeneniia preparata Dibikor v kompleksnoi terapii nealkogol'noi zhirovoi bolezni pecheni. Farmateka. 2010; 13: 63–7. [in Russian]
62. Shestakova M.V., Chugunova L.A., Shamkhalova M.Sh. Opyt primeneniia Dibikora pri sakharnom diabete 2 tipa. Sakharnyi diabet. 2007; 1. [in Russian]
63. Ametov A.S., Kochergina I.I., Elizarova E.P. Opyt primeneniia Dibikora pri sakharnom diabete 2 tipa. Problemy endokrinologii. 2007; 53 (4): 18–23. [in Russian]
64. Kudinov V.I., Zolotareva N.V., Shul'ga Iu.V. Izuchenie klinicheskoi effektivnosti Dibikora pri sakharnom diabete II tipa. Glavnyi vrach. Farmatsiia. 2007; 1 (9): 17–9. [in Russian]
65. Mkrtumian A.M., Podachina S.V., Petrachenko V.V. Dibikor – effektivnoe i bezopasnoe sredstvo dlia lecheniia sakharnogo diabeta. Effektivnaia farmakoterapiia v endokrinologii. 2008; 2: 34–9. [in Russian]
66. Nedosugova L.V. Mesto Dibikora v kompleksnoi terapii sakharnogo diabeta (literaturnyi obzor). Farmateka. 2008; 17: 22–7. [in Russian]
67. Bondar' I.A., Shabel'nikova O.Iu., Alina A.R. Antioksidant Dibikor v lechenii sosudistykh oslozhnenii sakharnogo diabeta 2 tipa. Problemy endokrinologii. 2009; 55 (2): 41–5. [in Russian]
68. Vorokhobina N.V., Kuznetsova A.V. Primenenie Dibikora u bol'nykh sakharnym diabetom 2 tipa i metabolicheskim sindromom. RMZh. Endokrinologiia. 2010; 118 (30): 1816–9. [in Russian]
69. Severina T.I., Popkova E.N., Trel'skaia N.Iu., Emel'ianov V.V. Klinicheskaia i metabolicheskaia effektivnost' preparata Dibikor u bol'nykh sakharnym diabetom 2 tipa. Farmateka. 2011; 5: 126–9. [in Russian]
70. Pertseva T.A., Pertseva N.O., Mishchenko N.A., Bratus' E.V. Novye vozmozhnosti metabolicheskoi terapii u patsientov s sakharnym diabetom 1 i 2 tipov. Medichni perspektivi. 2011; XVI/2: 1–7. [in Russian]
71. Manovitskaia A.V. Metabolicheskaia terapiia u patsientov s metabolicheskim sindromom. Poliklinika. 2012; 2/1: 25–8. [in Russian]

М.Е.Стаценко*, С.В.Туркина, И.А.Тыщенко, Е.Е.Горбачева

ФГБОУ ВО «Волгоградский государственный медицинский университет» Минздрава России. 400131, Россия, Волгоград, пл. Павших Борцов, д. 1
*mestatsenko@rambler.ru

________________________________________________

M.E.Statsenko*, S.V.Turkina, I.A.Tyshchenko, E.Е.Gorbacheva

Volgograd State Medical University of the Ministry of Health of the Russian Federation. 400131, Russian Federation, Volgograd, pl. Pavshikh Bortsov, d. 1
*mestatsenko@rambler.ru