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Возможности хондроитина сульфата и глюкозамина в качестве адъювантной терапии хронической боли в спине
Воробьева О.В. Возможности хондроитина сульфата и глюкозамина в качестве адъювантной терапии хронической боли в спине. Consilium Medicum. 2017; 19 (9): 59–64. DOI: 10.26442/2075-1753_19.9.59-64
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Vorobyova O.V. Chondroitin sulfate and glucosamine as an adjuvant therapy for chronic back pain. Consilium Medicum. 2017; 19 (9): 59–64. DOI: 10.26442/2075-1753_19.9.59-64
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Аннотация
С возрастом дегенеративные изменения суставного аппарата позвоночника у большинства пациентов приобретают статус ведущей причины в рецидивировании боли в спине. Работа фокусируется на новейших исследованиях влияния хондроитина сульфата и глюкозамина на воспалительные процессы, ассоциированные с дегенеративными изменениями суставного аппарата позвоночника. Анализ данных клинических исследований эффективности комбинированного препарата АРТРА® при хронической боли в спине позволяет рассматривать его как перспективное лекарство для купирования и профилактики рецидивов боли в спине.
Ключевые слова: хроническая боль в спине, суставной аппарат позвоночника, хондроитин сульфат и глюкозамин, АРТРА.
Ключевые слова: хроническая боль в спине, суставной аппарат позвоночника, хондроитин сульфат и глюкозамин, АРТРА.
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With age, degenerative changes in the articular apparatus of the spine in most patients become the leading cause in the recurrence of back pain. The work focuses on the latest research on the effects of chondroitin sulfate and glucosamine on inflammatory processes associated with degenerative changes in the joint apparatus of the spine. Analysis of clinical trials data on the effectiveness of the combined ARTRA® preparation in chronic back pain allows one to consider it as a promising drug for the relief and prevention of relapses in back pain.
Key words: chronic back pain, articular apparatus of the spine, chondroitin sulfate and glucosamine, ARTRA.
Полный текст
Список литературы
1. Muraki S, Akune T, Oka H et al. Impact of knee and low back pain on health-related quality of life in Japanese women: The Research on Osteoarthritis Against Disability (ROAD). Mod Rheumatol 2010; 20: 444–51.
2. Dionne CE, Kunn KM, Croft PR. Does back pain prevalence really decrease with increasing age? A systematic review. Age Ageing 2006; 35: 229–34.
3. Leboeuf-Yde C, Nielsen J, Kyvik KO et al. Pain in the lumbar, thoracic or cervical regions: do age and gender matter? A population-based study of 34,902 Danish twins 20–71 years of age. BMC Musculoskelet Disord 2009; 20: 39.
4. Воробьева О.В., Вауличева А.Л. Хронизация боли в спине у мужчин трудоспособного возраста. Врач. 2010; 9: 47–50. / Vorobeva O.V., Vaulicheva A.L. Khronizatsiia boli v spine u muzhchin trudosposobnogo vozrasta. Vrach. 2010; 9: 47–50. [in Russian]
5. Kolb E, Canjuga M, Bauer GF, Läubli T. Course of back pain across 5 years: a retrospective cohort study in the general population of Switzerland. Spine 2011; 36 (4): E268–73.
6. Clarke TC, Nahin RL, Barnes PM, Stussman BJ. National Center for Health Statistics Reports. Use of Complementary Health Approaches for Musculoskeletal Pain Disorders Among Adult. United States, 2012. https://www.cdc.gov/nchs/data/nhsr/nhsr098.pdf
7. Pearce RH, Grimmer BJ, Adams ME. Degeneration and the chemical composition of the human lumbar intervertebral disc. J Orthop Res 1987; 5 (2): 198–205.
8. Samartzis D, Karppinen J, Mok F et al. A population-based study of juvenile disc degeneration and its association with overweight and obesity, low back pain, and diminished functional status. J Bone Joint Surg Am 2011; 93 (7): 662–70.
9. Gandhi R, Woo KM, Zywiel MG, Rampersaud YR. Metabolic syndrome increases the prevalence of spine osteoarthritis. Orthop Surg 2014; 6 (1): 23–7.
10. Алексеева Л.И., Чичасова Н.В., Мендель О.И. Рациональный выбор базисной терапии при остеоартрозе. Результаты открытого рандомизированного многоцентрового исследования препарата АРТРА в России. РМЖ. 2005; 13 (24): 1637–40. / Alekseeva L.I., Chichasova N.V., Mendel' O.I. Ratsional'nyi vybor bazisnoi terapii pri osteoartroze. Rezul'taty otkrytogo randomizirovannogo mnogotsentrovogo issledovaniia preparata ARTRA v Rossii. RMZh. 2005; 13 (24): 1637–40. [in Russian]
11. Souich P. Absorption, distribution and mechanism of action of SYSADOAS. Pharmacol Ther 2014; 142 (3): 362–74.
12. Raynauld JP, Pelletier JP, Abram F et al. Long-Term Effects of Glucosamine and Chondroitin Sulfate on the Progression of Structural Changes in Knee Osteoarthritis: Six-Year Followup Data From the Osteoarthritis Initiative. Ann Rheum Dis 2016; 75 (1): 37–44.
13. Singh G, Alekseeva L, Alekseev V et al. Conbination treatment with glucosamine-chondroitin sulfate reduces pain, disability and NSAID consumption in patients with chronic low back pain: final results from a large, commute – based, pilot, open prospective study. Ann Rheum Dis 2014; 73 (Suppl. 2): 300.
14. Kocsis JJ, Harkaway S, Snyder R. Biological effects of the metabolites of dimethyl sulfoxide. Ann NY Acad Sci 1975; 243: 104–9.
15. Алексеева Л.И., Шарапова Е.П., Кашеварова Н.Г. и др. Применение АРТРА MСM ФОРТЕ у пациентов с остеоартрозом коленного сустава: результаты рандомизированного открытого сравнительного изучения эффективности и переносимости препарата. Терапевт. арх. 2015; 87 (12): 49–54. / Alekseeva L.I., Sharapova E.P., Kashevarova N.G. i dr. Primenenie ARTRA MSM FORTE u patsientov s osteoartrozom kolennogo sustava: rezul'taty randomizirovannogo otkrytogo sravnitel'nogo izucheniia effektivnosti i perenosimosti preparata. Terapevt. arkh. 2015; 87 (12): 49–54. [in Russian]
2. Dionne CE, Kunn KM, Croft PR. Does back pain prevalence really decrease with increasing age? A systematic review. Age Ageing 2006; 35: 229–34.
3. Leboeuf-Yde C, Nielsen J, Kyvik KO et al. Pain in the lumbar, thoracic or cervical regions: do age and gender matter? A population-based study of 34,902 Danish twins 20–71 years of age. BMC Musculoskelet Disord 2009; 20: 39.
4. Воробьева О.В., Вауличева А.Л. Хронизация боли в спине у мужчин трудоспособного возраста. Врач. 2010; 9: 47–50. / Vorobeva O.V., Vaulicheva A.L. Khronizatsiia boli v spine u muzhchin trudosposobnogo vozrasta. Vrach. 2010; 9: 47–50. [in Russian]
5. Kolb E, Canjuga M, Bauer GF, Läubli T. Course of back pain across 5 years: a retrospective cohort study in the general population of Switzerland. Spine 2011; 36 (4): E268–73.
6. Clarke TC, Nahin RL, Barnes PM, Stussman BJ. National Center for Health Statistics Reports. Use of Complementary Health Approaches for Musculoskeletal Pain Disorders Among Adult. United States, 2012. https://www.cdc.gov/nchs/data/nhsr/nhsr098.pdf
7. Pearce RH, Grimmer BJ, Adams ME. Degeneration and the chemical composition of the human lumbar intervertebral disc. J Orthop Res 1987; 5 (2): 198–205.
8. Samartzis D, Karppinen J, Mok F et al. A population-based study of juvenile disc degeneration and its association with overweight and obesity, low back pain, and diminished functional status. J Bone Joint Surg Am 2011; 93 (7): 662–70.
9. Gandhi R, Woo KM, Zywiel MG, Rampersaud YR. Metabolic syndrome increases the prevalence of spine osteoarthritis. Orthop Surg 2014; 6 (1): 23–7.
10. Алексеева Л.И., Чичасова Н.В., Мендель О.И. Рациональный выбор базисной терапии при остеоартрозе. Результаты открытого рандомизированного многоцентрового исследования препарата АРТРА в России. РМЖ. 2005; 13 (24): 1637–40. / Alekseeva L.I., Chichasova N.V., Mendel' O.I. Ratsional'nyi vybor bazisnoi terapii pri osteoartroze. Rezul'taty otkrytogo randomizirovannogo mnogotsentrovogo issledovaniia preparata ARTRA v Rossii. RMZh. 2005; 13 (24): 1637–40. [in Russian]
11. Souich P. Absorption, distribution and mechanism of action of SYSADOAS. Pharmacol Ther 2014; 142 (3): 362–74.
12. Raynauld JP, Pelletier JP, Abram F et al. Long-Term Effects of Glucosamine and Chondroitin Sulfate on the Progression of Structural Changes in Knee Osteoarthritis: Six-Year Followup Data From the Osteoarthritis Initiative. Ann Rheum Dis 2016; 75 (1): 37–44.
13. Singh G, Alekseeva L, Alekseev V et al. Conbination treatment with glucosamine-chondroitin sulfate reduces pain, disability and NSAID consumption in patients with chronic low back pain: final results from a large, commute – based, pilot, open prospective study. Ann Rheum Dis 2014; 73 (Suppl. 2): 300.
14. Kocsis JJ, Harkaway S, Snyder R. Biological effects of the metabolites of dimethyl sulfoxide. Ann NY Acad Sci 1975; 243: 104–9.
15. Алексеева Л.И., Шарапова Е.П., Кашеварова Н.Г. и др. Применение АРТРА MСM ФОРТЕ у пациентов с остеоартрозом коленного сустава: результаты рандомизированного открытого сравнительного изучения эффективности и переносимости препарата. Терапевт. арх. 2015; 87 (12): 49–54. / Alekseeva L.I., Sharapova E.P., Kashevarova N.G. i dr. Primenenie ARTRA MSM FORTE u patsientov s osteoartrozom kolennogo sustava: rezul'taty randomizirovannogo otkrytogo sravnitel'nogo izucheniia effektivnosti i perenosimosti preparata. Terapevt. arkh. 2015; 87 (12): 49–54. [in Russian]
________________________________________________
1. Muraki S, Akune T, Oka H et al. Impact of knee and low back pain on health-related quality of life in Japanese women: The Research on Osteoarthritis Against Disability (ROAD). Mod Rheumatol 2010; 20: 444–51.
2. Dionne CE, Kunn KM, Croft PR. Does back pain prevalence really decrease with increasing age? A systematic review. Age Ageing 2006; 35: 229–34.
3. Leboeuf-Yde C, Nielsen J, Kyvik KO et al. Pain in the lumbar, thoracic or cervical regions: do age and gender matter? A population-based study of 34,902 Danish twins 20–71 years of age. BMC Musculoskelet Disord 2009; 20: 39.
4. Vorobeva O.V., Vaulicheva A.L. Khronizatsiia boli v spine u muzhchin trudosposobnogo vozrasta. Vrach. 2010; 9: 47–50. [in Russian]
5. Kolb E, Canjuga M, Bauer GF, Läubli T. Course of back pain across 5 years: a retrospective cohort study in the general population of Switzerland. Spine 2011; 36 (4): E268–73.
6. Clarke TC, Nahin RL, Barnes PM, Stussman BJ. National Center for Health Statistics Reports. Use of Complementary Health Approaches for Musculoskeletal Pain Disorders Among Adult. United States, 2012. https://www.cdc.gov/nchs/data/nhsr/nhsr098.pdf
7. Pearce RH, Grimmer BJ, Adams ME. Degeneration and the chemical composition of the human lumbar intervertebral disc. J Orthop Res 1987; 5 (2): 198–205.
8. Samartzis D, Karppinen J, Mok F et al. A population-based study of juvenile disc degeneration and its association with overweight and obesity, low back pain, and diminished functional status. J Bone Joint Surg Am 2011; 93 (7): 662–70.
9. Gandhi R, Woo KM, Zywiel MG, Rampersaud YR. Metabolic syndrome increases the prevalence of spine osteoarthritis. Orthop Surg 2014; 6 (1): 23–7.
10. Alekseeva L.I., Chichasova N.V., Mendel' O.I. Ratsional'nyi vybor bazisnoi terapii pri osteoartroze. Rezul'taty otkrytogo randomizirovannogo mnogotsentrovogo issledovaniia preparata ARTRA v Rossii. RMZh. 2005; 13 (24): 1637–40. [in Russian]
11. Souich P. Absorption, distribution and mechanism of action of SYSADOAS. Pharmacol Ther 2014; 142 (3): 362–74.
12. Raynauld JP, Pelletier JP, Abram F et al. Long-Term Effects of Glucosamine and Chondroitin Sulfate on the Progression of Structural Changes in Knee Osteoarthritis: Six-Year Followup Data From the Osteoarthritis Initiative. Ann Rheum Dis 2016; 75 (1): 37–44.
13. Singh G, Alekseeva L, Alekseev V et al. Conbination treatment with glucosamine-chondroitin sulfate reduces pain, disability and NSAID consumption in patients with chronic low back pain: final results from a large, commute – based, pilot, open prospective study. Ann Rheum Dis 2014; 73 (Suppl. 2): 300.
14. Kocsis JJ, Harkaway S, Snyder R. Biological effects of the metabolites of dimethyl sulfoxide. Ann NY Acad Sci 1975; 243: 104–9.
15. Alekseeva L.I., Sharapova E.P., Kashevarova N.G. i dr. Primenenie ARTRA MSM FORTE u patsientov s osteoartrozom kolennogo sustava: rezul'taty randomizirovannogo otkrytogo sravnitel'nogo izucheniia effektivnosti i perenosimosti preparata. Terapevt. arkh. 2015; 87 (12): 49–54. [in Russian]
Авторы
О.В.Воробьева
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М.Сеченова» Минздрава России. 119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2
ovvorobeva@mail.ru
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М.Сеченова» Минздрава России. 119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2
ovvorobeva@mail.ru
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O.V.Vorobyova
I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation. 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2
ovvorobeva@mail.ru
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