Выбор анальгетика при боли в спине сквозь призму лекарственной безопасности и коморбидности: в фокусе – флупиртин

1. Трухан Д.И. Выбор лекарственного препарата с позиций рациональной фармакотерапии. Consilium Medicum. 2013; 11: 45–9. / Trukhan D.I. Vybor lekarstvennogo preparata s pozitsii ratsional'noi farmakoterapii. Consilium Medicum. 2013; 11: 45–9. [in Russian]
2. Трухан Д.И. Рациональная фармакотерапия в кардиологии сквозь призму коморбидности и лекарственной безопасности. Справочник поликлинического врача. 2015; 1: 26–31. / Trukhan D.I. Ratsional'naia farmakoterapiia v kardiologii skvoz' prizmu komorbidnosti i lekarstvennoi bezopasnosti. Handbook for Practitioners Doctors. 2015; 1: 26–31. [in Russian]
3. Лазебник Л.Б. Полиморбидность и старение. Новости медицины и фармации. 2007; 1 (205). URL: http://archive.today/smbi / Lazebnik L.B. Polimorbidnost' i starenie. Novosti meditsiny i farmatsii. 2007; 1 (205). URL: http://archive.today/smbi [in Russian]
4. Белялов Ф.И. Двенадцать тезисов коморбидности. Клин. медицина. 2009; 12: 69–71. / Belialov F.I. Dvenadtsat' tezisov komorbidnosti. Klin. meditsina. 2009; 12: 69–71. [in Russian]
5. Цурко В.В. Дорсопатия у пожилых: патобиология и комплексная терапия в клинической практике. Терапевт. арх. 2012; 10: 119–24. / Tsurko V.V. Dorsopatiia u pozhilykh: patobiologiia i kompleksnaia terapiia v klinicheskoi praktike. Terapevt. arkh. 2012; 10: 119–24. [in Russian]
6. Котова О.В., Воробьева О.В. Остеохондроз как причина дорсопатии. Consilium Medicum (Прил. Неврология и Ревматология). 2012; 2: 80–3. / Kotova O.V., Vorob'eva O.V. Osteokhondroz kak prichina dorsopatii. Consilium Medicum (Suppl. Neurology and Rheumatology). 2012; 2: 80–3. [in Russian]
7. Пимонова И. Лечение дорсалгии на амбулаторно-поликлиническом этапе в городской больнице. Врач. 2010; 3: 70–3. / Pimonova I. Lechenie dorsalgii na ambulatorno-poliklinicheskom etape v gorodskoi bol'nitse. Vrach. 2010; 3: 70–3. [in Russian]
8. Бойцов И.В. Дорсопатии шейного, грудного, поясничного отделов позвоночника: особенности неврологических осложнений (обзор литературы). Справ. врача общей практики. 2013; 5: 73–8. / Boitsov I.V. Dorsopatii sheinogo, grudnogo, poiasnichnogo otdelov pozvonochnika: osobennosti nevrologicheskikh oslozhnenii (obzor literatury). Sprav. vracha obshchei praktiki. 2013; 5: 73–8. [in Russian]
9. Трухан Д.И. Дорсалгия: актуальные аспекты лечения на амбулаторно-поликлиническом этапе. Справочник поликлинического врача. 2017; 2: 78–83. / Trukhan D.I. Dorsalgia: actual aspects of treatment at the ambulatory-polyclinic stage. Handbook for Practitioners Doctors. 2017; 2: 78–83. [in Russian]
10. Манвелов Л.С., Тюрников В.М. Поясничные боли (этиология, клиника, диагностика и лечение). Рус. мед. журн. 2009; 20: 1290–4. / Manvelov L.S., Tiurnikov V.M. Poiasnichnye boli (etiologiia, klinika, diagnostika i lechenie). Rus. med. zhurn. 2009; 20: 1290–4. [in Russian]
11. Трухан Д.И. Скелетно-мышечные боли: актуальные аспекты лечения на этапе оказания первичной медико-санитарной помощи. Consilium Medicum. 2017; 19 (2): 129–35. / Trukhan D.I. Musculoskeletal pain: actual aspects of treatment at the stage of primary medical care. Consilium Medicum. 2017; 19 (2): 129–135. [in Russian]
12. Подчуфарова Е.В. Скелетно-мышечные боли в спине. РМЖ. 2005; 12: 836–40. / Podchufarova E.V. Skeletno-myshechnye boli v spine. RMZh. 2005; 12: 836–40. [in Russian]
13. Котов А.С., Елисеев Ю.В. Поясничная боль. Журн. неврологии и психиатрии им. С.С.Корсакова. 2012; 5: 90–3. / Kotov A.S., Eliseev Iu.V. Poiasnichnaia bol'. Zhurn. nevrologii i psikhiatrii im. S.S.Korsakova. 2012; 5: 90–3. [in Russian]
14. Рачин А.П., Якунин К.А., Демешко А.В. Миофасциальный болевой синдром. М.: ГЭОТАР-Медиа, 2011. / Rachin A.P., Iakunin K.A., Demeshko A.V. Miofastsial'nyi bolevoi sindrom. M.: GEOTAR-Media, 2011. [in Russian]
15. Тревелл Дж. Г., Симонс Д.Г. Миофасциальные боли. Т. 1. М.: Медицина, 1989. / Trevell Dzh. G., Simons D.G. Miofastsial'nye boli. T. 1. M.: Meditsina, 1989. [in Russian]
16. Вознесенская Т.Г. Миофасциальные болевые синдромы. Consilium Medicum. 2002; 4 (8).URL: http://con-med.ru/magazines/consilium_medicum/consilium_medicum-08-2002/ / Voznesenskaia T.G. Miofastsial'nye bolevye sindromy. Consilium Medicum. 2002; 4 (8). URL: http://con-med.ru/magazines/consilium_medicum/consilium_medicum-08-2002/ [in Russian]
17. Воробьева О.В. Скелетная мускулатура как причина локальных болевых синдромов. Consilium Medicum. 2012; 14 (2). / Vorobeva O.V. Skeletnaia muskulatura kak prichina lokal'nykh bolevykh sindromov. Consilium Medicum. 2012; 14 (2). URL: http://con-med.ru/magazines/consilium_medicum/consilium_medicum-02-2012/ [in Russian]
18. Насонов Е.Л., Каратеев А.Е. Применение нестероидных противовоспалительных препаратов. Клинические рекомендации. РМЖ. 2006; 25. / Nasonov E.L., Karateev A.E. Primenenie nesteroidnykh protivovospalitel'nykh preparatov. Klinicheskie rekomendatsii. RMZh. 2006; 25. URL: http://rmj.ru/articles_4309.htm [in Russian]
19. Трухан Д.И., Давыдов Е.Л. Дорсалгия: актуальные аспекты терапии на этапе оказания первичной медико-санитарной помощи. Consilium Medicum. 2015; 17 (9): 82–7. / Trukhan D.I., Davydov E.L. Dorsalgia: topical aspects of treatment at stages of primary health care. Consilium Medicum. 2015; 17 (9): 82–7. [in Russian]
20. Ревматология. Национальное руководство. Под ред. Е.Л.Насонова. М.: ГЭОТАР-Медиа, 2008. / Revmatologiia. Natsionalnoe rukovodstvo. Pod red. E.L.Nasonova. M.: GEOTAR-Media, 2008 [in Russian]
21. Рациональная фармакотерапия ревматических заболеваний. Руководство для практикующих врачей. Под общ. ред. В.А.Насоновой, Е.Л.Насонова. М.: Литтерра, 2007. / Ratsionalnaia farmakoterapiia revmaticheskikh zabolevanii: Rukovodstvo dlia praktikuiushchikh vrachei. Pod obshch. red. V.A.Nasonovoi, E.L.Nasonova. M.: Litterra, 2007. [in Russian]
22. Насонов Е.Л., Каратеев А.Е. Применение нестероидных противовоспалительных препаратов. Клинические рекомендации. Рус. мед. журн. 2006; 25: 1769–77. / Nasonov E.L., Karateev A.E. Primenenie nesteroidnykh protivovospalitelnykh preparatov. Klinicheskie rekomendatsii. Rus. med. zhurn. 2006; 25: 1769–77. [in Russian]
23. Каратеев А.Е., Насонов Е.Л. НПВП – ассоциированная патология ЖКТ: реальное состояние дел в России. Рус. мед. журн. 2006; 15: 1073–8. / Karateev A.E., Nasonov E.L. NPVP – assotsiirovannaia patologiia ZhKT: realnoe sostoianie del v Rossii. Rus. med. zhurn. 2006; 15: 1073–8. [in Russian]
24. Трухан Д.И., Викторова И.А. Внутренние болезни. Кардиология. Ревматология. М.: Мед. информагентство, 2013. / Trukhan D.I., Viktorova I.A. Vnutrennie bolezni. Kardiologiia. Revmatologiia. M.: Med. informagentstvo, 2013. [in Russian]
25. Верткин А.Л., Носова А.В., Алисов В.А., Заиченко Д.М. Выбор нестероидных противовоспалительных препаратов для купирования болевого синдрома в клинической практике. Consilium Medicum. 2013; 15 (8): 63–7. / Vertkin A.L., Nosova A.V., Alisov V.A., Zaichenko D.M. Vybor nesteroidnykh protivovospalitelnykh preparatov dlia kupirovaniia bolevogo sindroma v klinicheskoi praktike. Consilium Medicum. 2013; 15 (8): 63–7. [in Russian]
26. Трухан Д.И., Филимонов С.Н., Викторова И.А. Клиника, диагностика и лечение основных ревматических болезней. СПб.: СпецЛит, 2014. / Trukhan D.I., Filimonov S.N., Viktorova I.A. Klinika, diagnostika i lechenie osnovnykh revmaticheskikh boleznei. SPb.: SpetsLit, 2014. [in Russian]
27. Лапина Т.Л. Гастропатия, индуцированная нестероидными противовоспалительными препаратами: пути решения проблемы. Рус. мед. журн. 2009; 2: 54–7. / Lapina T.L. Gastropatiia, indutsirovannaia nesteroidnymi protivovospalitelnymi preparatami: puti resheniia problemy. Rus. med. zhurn. 2009; 2: 54–7. [in Russian]
28. Каратеев А.Е., Насонов Е.Л., Яхно Н.Н. и др. Клинические рекомендации «Рациональное применение нестероидных противовоспалительных препаратов (НПВП) в клинической практике». Соврем. ревматология. 2015; 9 (1): 4–23. / Karateev A.E., Nasonov E.L., Iakhno N.N. i dr. Klinicheskie rekomendatsii «Ratsionalnoe primenenie nesteroidnykh protivovospalitelnykh preparatov (NPVP) v klinicheskoi praktike». Sovrem. revmatologiia. 2015; 9 (1): 4–23. [in Russian]
29. Roth SH. Nonsteroidal anti-inflammatory drug gastropathy: new avenues for safety. Clin Interv Aging 2011; 6: 125–31.
30. Roth SH. Coming to terms with nonsteroidal anti-inflammatory drug gastropathy. Drugs 2012; 72 (7): 873–9.
31. Трухан Д.И. Выбор нестероидного противовоспалительного препарата с позиций профилактики НПВП-гастропатии и лекарственной безопасности. Consilium Medicum. 2014; 16 (8): 14–9. / Trukhan D.I. Vybor nesteroidnogo protivovospalitelnogo preparata s pozitsii profilaktiki NPVP-gastropatii i lekarstvennoi bezopasnosti. Consilium Medicum. 2014; 16 (8): 14–9. [in Russian]
32. Трухан Д.И. Нестероидные противовоспалительные препараты сквозь призму коморбидности и лекарственной безопасности: в фокусе – амтолметин гуацил. Consilium Medicum. 2015; 17 (2): 27–33. / Trukhan D.I. Nonsteroidal anti-inflammatory drugs through the prism comorbidity and drug safety: in focus amtolmetin guatsil. Consilium Medicum. 2015; 17 (2): 27–33. [in Russian]
33. Вялов С.С. Противовоспалительная терапия и гастротоксичность: реальные возможности профилактики. Рус. мед. журн. 2014; 22. / Vialov S.S. Protivovospalitelnaia terapiia i gastrotoksichnost: realnye vozmozhnosti profilaktiki. Rus. med. zhurn. 2014; 22. URL: http://rmj.ru/articles_9750.htm [in Russian]
34. Antman EM, Bennett JS, Daugherty A et al. Use of nonsteroidal antiinflammatory drugs. An Update for Clinicians. A Scientific Statement from the American Heart Association. Circulation 2007; 115: 1634–42.
35. Bhatt DL, Scheiman J, Abraham NS et al. ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. Circulation 2008; 118: 1894–909.
36. Lanza FL, Chan FK, Quigley EM. Guidelines for Prevention of NSAID-Related Ulcer Complications. Am J Gastroenterol 2009; 104: 728–38.
37. Chan FK, Abraham NS, Scheiman JM, Laine L. Management of Patients on Nonsteroidal Anti-inflammatory Drugs: A Clinical Practice Recommendation From the First International Working Party on Gastrointestinal and Cardiovascular Effects of Nonsteroidal Anti-inflammatory Drugs and Anti-platelet Agents. Am J Gastroenterol 2008; 103: 2908–18.
38. Пахомова И.Г. Новые возможности в минимизации риска НПВП-индуцированных гастропатий. Рус. мед. журн. 2014; 10: 772–6. / Pakhomova I.G. Novye vozmozhnosti v minimizatsii riska NPVP-indutsirovannykh gastropatii. Rus. med. zhurn. 2014; 10: 772–6. [in Russian]
39. Плотникова Е.Ю., Грачева Т.Ю. Эрозивно-язвенные поражения желудочно-кишечного тракта и простагландины: проблемный дуэт. Справочник поликлинического врача. 2016; 4: 32–7. / Plotnikova E.Iu., Gracheva T.Iu. Erozivno-iazvennye porazheniia zheludochno-kishechnogo trakta i prostaglandiny: problemnyi duet. Handbook for Practitioners Doctors. 2016; 4: 32–7. [in Russian]
40. Rostom A, Moayyedi P, Hunt R. Canadian Association of Gastroenterology Consensus Group. Canadian consensus guidelines on long-term nonsteroidal anti-inflammatory drug therapy and the need for gastroprotection: benefits versus risks. Aliment Pharmacol Ther 2009; 29 (5): 481–96.
41. Scheiman JM, Hindley CE. Strategies to optimize treatment with NSAIDs in patients at risk for gastrointestinal and cardiovascular adverse events. Clin Ther 2010; 32 (4): 667–77.
42. Каратеев А.Е. Что лучше для профилактики НПВП-гастропатии: коксибы или комбинация «традиционных» НПВП и гастропротектора? Рус. мед. журн. 2013; 13. / Karateev A.E. Chto luchshe dlia profilaktiki NPVP-gastropatii: koksiby ili kombinatsiia «traditsionnykh» NPVP i gastroprotektora? Rus. med. zhurn. 2013; 13. URL: http://rmj.ru/articles_8770.htm [in Russian]
43. Popular heartburn medication may increase ischemic stroke risk. American Heart Association Meeting Report – Presentation: 391–Session: EP.AOS.765. URL: http://newsroom.heart.org/news/Xpopular-heartburn-medication-may-increase-ischemic-stroke-risk
44. Xie Y, Bowe B, Li T et al. Risk of death among users of Proton Pump Inhibitors: a longitudinal observational cohort study of United States veterans. BMJ Open 2017; 7 (6): e015735. DOI: 10.1136/bmjopen-2016-015735
45. Трухан Д.И., Тарасова Л.В. Рациональная фармакотерапия и лекарственная безопасность в кардиологии. Справочник поликлинического врача. 2013; 5: 21–6. / Trukhan D.I., Tarasova L.V. Ratsionalnaia farmakoterapiia i lekarstvennaia bezopasnost v kardiologii. Handbook for Practitioners Doctors. 2013; 5: 21–6. [in Russian]
46. FDA Public Health Advisory: FDA announces important changes and additional warnings for COX-2 selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs). URL:http://www.fda.gov/ cder/drug/advisory/ COX2.htm
47. Пиманов С.И., Дикарева Е.А., Макаренко Е.В. Как уменьшить гастроинтестинальный риск при использовании нестероидных противовоспалительных препаратов? Consilium Medicum. 2014; 16 (2): 95–9. / Pimanov S.I., Dikareva E.A., Makarenko E.V. Kak umenshit gastrointestinalnyi risk pri ispolzovanii nesteroidnykh protivovospalitelnykh preparatov? Consilium Medicum. 2014; 16 (2): 95–9. [in Russian]
48. Gislason G, Jacobsen S, Rasmussen J et al. Risk of death or reinfarction associated with the use of selective cyclooxygenase-2 inhibitors and nonselective nonsteroidal antiinflam-matory drugs after acute myocardial infarction. Circulation 2006; 113 (25): 2906–13.
49. Trelle S, Reichenbach S, Wandel S et al. Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. BMJ 2011; 342: 7086. URL: http://www.bmj.com/content/342/bmj.c7086
50. Мареев В.Ю., Агеев Ф.Т., Арутюнов Г.П. и др. Национальные рекомендации ОССН, РКО и РНМОТ по диагностике и лечению ХСН (4-й пересмотр). Сердечная недостаточность. 2013; 7 (81): 379–472. / Mareev V.Iu., Ageev F.T., Arutiunov G.P. i dr. Natsionalnye rekomendatsii OSSN, RKO i RNMOT po diagnostike i lecheniiu KhSN (4-i peresmotr). Serdechnaia nedostatochnost. 2013; 7 (81): 379–472. [in Russian]
51. Котова О.В., Акарачкова Е.С. Место препарата нолодатак в лечении боли в спине. Фарматека. 2015; 13 (306): 70–3. / Kotova O.V., Akarachkova E.S. Mesto preparata nolodatak v lechenii boli v spine. Farmateka. 2015; 13 (306): 70–3. [in Russian]
52. Каратеев А.Е. Что может стать альтернативой нестероидным противовоспалительным препаратам для контроля острой скелетно-мышечной боли у пациента, имевшего в анамнезе инфаркт миокарда и желудочно-кишечное кровотечение? Consilium Medicum. 2016; 18 (2): 141–9. / Karateev A.E. What can be an alternative to non-steroidal anti-inflammatory drugs for the control of acute musculoskeletal pain in a patient with a history of myocardial infarction and gastrointestinal bleeding? Consilium Medicum. 2016; 18 (2): 141–9. [in Russian]
53. Магомедова М., Камчатнов П. Эффективность и безопасность лечения пациентов с поясничной болью. Врач. 2016; 3: 29–31. / Magomedova M., Kamchatnov P. Effektivnost i bezopasnost lecheniia patsientov s poiasnichnoi boliu. Vrach. 2016; 3: 29–31. [in Russian]
54. Котова О.В., Акарачкова Е.С. Боль в шее: возможности терапии. Терапия. 2016; 2 (6): 70–5. / Kotova O.V., Akarachkova E.S. Bol v shee: vozmozhnosti terapii. Terapiia. 2016; 2 (6): 70–5. [in Russian]
55. Подымова И.Г., Данилов А.Б. Особенности терапии боли в нижней части спины у пациентов с противопоказаниями к нестероидным противовоспалительным препаратам. Consilium Medicum. 2016; 18 (2): 50–2. / Podymova I.G., Danilov A.B. Features of treatment of pain in the lower back in patients with contraindications for nonsteroidal anti-inflammatory drugs. Consilium Medicum. 2016; 18 (2): 50–2. [in Russian]
56. Камчатнов П.Р., Магомедова М.А., Чугунов А.В. Проблема эффективности и безопасности лечения пациента с поясничной болью. Терапия. 2016; 1: 75–81. / Kamchatnov P.R., Magomedova M.A., Chugunov A.V. Problema effektivnosti i bezopasnosti lecheniia patsienta s poiasnichnoi boliu. Terapiia. 2016; 1: 75–81. [in Russian]
57. Азимова Ю.Э. Боль в спине: бремя сопутствующих заболеваний и подбор эффективной терапии. Терапия. 2017; 1: 144–8. / Azimova Iu.E. Bol v spine: bremia soputstvuiushchikh zabolevanii i podbor effektivnoi terapii. Terapiia. 2017; 1: 144–8. [in Russian]
58. Камчатнов П.Р., Ханмурзаева Н.Б., Ханмурзаева С.Б. Нолодотак (флупиртин) в лечении пациентов с дорсопатией. Терапия. 2017; 3: 76–83. / Kamchatnov P.R., Khanmurzaeva N.B., Khanmurzaeva S.B. Nolodotak (flupirtin) v lechenii patsientov s dorsopatiei. Terapiia. 2017; 3: 76–83. [in Russian]
59. Ueberall MА, Mueller-Schwefe GН, Terhaag B. Efficacy and tolerability of flupirtine in subacute / chronic musculoskeletal pain – results of a patient level, pooled reanalysis of randomized, doubleblind, controlled trials. Int J Clin Pharmacol Ther 2011; 49: 637–47.
60. Jakob R, Krieglstein J. Influence of flupirtine on a G-protein coupled inwardly rectifying potassium current in hippocampal neurons. Br J Pharmacol 1997; 122: 1333–8.
61. Kornhuber J, Bleich S, Wiltfang J et al. Flupirtine shows functional NMDA receptor antagonism by enhancing Mg+ block via activation of voltage independent potassium channels. J Neural Transm 1999; 106 (9–10): 857–67.
62. Wörz R, Müller-Schwefe G, Stroehmann I et al. Back pain: Guidelines for drug therapy. Fortschr Med 2000; 142 (5): 27–33.
63. Szelenyi I. Flupirtine, a re-discovered drug, revisited. Inflamm Res 2013 Mar; 62 (3): 251–8.
64. Wörz R, Bolten W, Heller B et al. Flupirtine in comparison with chlormezanone in chronic musculoskeletal back pain. Results of a multicenter randomized double-blind study. Fortschr Med 1996; 114 (35–36): 500–4.
65. Perovic S, Pialoglou P, Schroder HC et al. Flupirtine increases the levels of glutathione and Bc1–2 in hNT (human Ntera/D1) neurons: mode of action of the drug-mediated anti-apoptotic effect. Eur J Pharmacol 1996; 317 (1): 157–64.
66. Klawe C, Maschke M. Flupirtine: pharmacology and clinical applications of a nonopioid analgesic and potentially neuroprotective compound. Expert Opin Pharmacother 2009; 10 (9): 1495–500.
67. Devulder J. Flupirtine in pain management: pharmacological properties and clinical use. CNS Drugs 2010; 24 (10): 867–81.
68. Raffa RB, Pergolizzi JV Jr. The evolving understanding of the analgesic mechanism of action of flupirtine. J Clin Pharm Ther 2012; 37 (1): 4–6.
69. Mueller-Schwefe G. Flupirtine in acute and chronic pain associated with muscle tenseness. Results of a postmarket surveillance study. Fortschr Med Orig 2003; 121 (1): 11–8.
70. Ringe JD et al. Analgesic Efficacy of Flupirtine in Primary Care of Patients with Osteoporosis Related Pain. A multivariate analysis. Arzneimittelforschung 2003; 53 (7): 496–502.
71. Левин Я.И., Стрыгин К.Н., Добровольская Л.Е. Катадолон в лечении боли в спине. Лечение нервных болезней. 2005; 6 (3): 12–7. / Levin Ia.I., Strygin K.N., Dobrovolskaia L.E. Katadolon v lechenii boli v spine. Lechenie nervnykh boleznei. 2005; 6 (3): 12–7. [in Russian]
72. Камчатнов П.Р., Батышева Т.Т., Ганжула П.А. и др. Применение катадолона у больных со спондилогенной дорсалгией. Журн. неврологии и психиатрии им. С.С.Корсакова. 2006; 106 (11): 46–8. / Kamchatnov P.R., Batysheva T.T., Ganzhula P.A. i dr. Primenenie katadolona u bolnykh so spondilogennoi dorsalgiei. Zhurn. nevrologii i psikhiatrii im. S.S.Korsakova. 2006; 106 (11): 46–8. [in Russian]
73. Эрдес Ш., Галушко Е., Зоткин Е. и др. Эффективность катадолона (флупиртина) у пациентов с болями в нижней части спины. Врач. 2007; 5: 56–9. / Erdes Sh., Galushko E., Zotkin E. i dr. Effektivnost katadolona (flupirtina) u patsientov s boliami v nizhnei chasti spiny. Vrach. 2007; 5: 56–9. [in Russian]
74. Алексеев В.В., Рачин А.П., Подчуфарова Е.В. Флупиртин (Катадолон) – нестандартный подход в терапии боли. Неврол. и ревматология. 2009; 2: 50–3. / Alekseev V.V., Rachin A.P., Podchufarova E.V. Flupirtin (Katadolon) – nestandartnyi podkhod v terapii boli. Nevrol. i revmatologiia. 2009; 2: 50–3. [in Russian]
75. Данилов А.Б., Николаева Н.С. Эффективность новой формы флупиртина (Катадолона форте) в лечении острой боли в спине. Managepain. 2013; 1: 44–8. / Danilov A.B., Nikolaeva N.S. Effektivnost novoi formy flupirtina (Katadolona forte) v lechenii ostroi boli v spine. Managepain. 2013; 1: 44–8. [in Russian]
76. Yadav G, Behera SS, Das SK et al. Role of flupirtine as a preemptive analgesic in patients undergoing laparoscopic cholecystectomy. J Anaesthesiol Clin Pharmacol 2015; 31 (2): 169–73.
77. Ueberall MA, Essner U, Müller-Schwefe GH. 2-week efficacy and tolerability of flupirtine MR and diclofenac in patients with acute low/back pain-results of a post-hoc subgroup analysis of patient-level data from four non-interventional studies. MMW Fortschr Med 2013; 155 (Suppl. 4): 115–23.
78. Li C, Ni J, Wang Z et al. Analgesic efficacy and tolerability of flupirtine vs. tramadol in patients with subacute low back pain: a double-blind multicentre trial. Curr Med Res Opin 2008; 24 (12): 3523–30.
79. Uberall MA, Mueller-Schwefe GH, Terhaag B. Efficacy and safety of flupirtine modified release for the management of moderate to severe chronic low back pain: results of SUPREME, a prospective randomized, double-blind, placebo- and active-controlled parallel-group phase IV study. Curr Med Res Opin 2012; 28 (10): 1617–34.
80. Рачин А.П. Десять доказательств успешного применения флупиртина (катадолона) при болях в нижней части спины. Лечение нервных болезней. 2007; 2: 35–9. / Rachin A.P. Desiat dokazatelstv uspeshnogo primeneniia flupirtina (katadolona) pri boliakh v nizhnei chasti spiny. Lechenie nervnykh boleznei. 2007; 2: 35–9. [in Russian]
81. Restrictions in the use of flupirtine-containing medicines – CMDh endorses PRAC recommendation. Press release. 28/06/2013. URL: http://www.ema.europa.eu/ema/ index.jsp curl=pages/news_and_events/news/2013/06/news_detail_001831.jsp&mid=WC0b01ac058004d5c1
82. Restrictions in the use of flupirtine-containing medicines. 13 September 2013. EMA/563900/ 2013. URL: http://www.ema.europa.eu/docs/en_GB/document_library/ Referrals_document/Flupirtine-containing_medicines/European_Commission_final_decision/ WC500155310.pdf
83. Harish S, Bhuvana K, Bengalorkar GM, Kumar T. Flupirtine: Clinical pharmacology. J Anaesth Clin Pharmacol 2012; 28: 172–7.
84. Treudler R, Pohle K, Simon JC. Flupirtine is a safe alternative drug in patients with hypersensitivity to NSAIDs. Eur J Clin Pharmacol 2011; 67 (9): 961–3.
85. Flupirtine (флупиртин). URL: https://www.vidal.ru/drugs/molecule/1338 / Flupirtine (flupirtin). URL: https://www.vidal.ru/drugs/molecule/1338 [in Russian]
86. Wörz R. Long-term-treatment of chronic pain patients with flupirtine – on hepatotoxicity and persistent effectiveness from 7 months to 22 years. MMW Fortschr Med 2014; 156 (Suppl. 4): 127–34.
87. Nicoletti P, Werk A, Sawle A et al. International Drug-induced Liver Injury Consortium. HLA-DRB1*16: 01-DQB1*05: 02 is a novel genetic risk factor for flupirtine-induced liver injury. Pharmacogenet Genomics 2016; 26 (5): 218–24.
88. Трухан Д.И. Рациональная фармакотерапия в гастроэнтерологии. Справочник поликлинического врача. 2012; 10: 18–24. / Trukhan D.I. Ratsionalnaia farmakoterapiia v gastroenterologii. Handbook for Practitioners Doctors. 2012; 10: 18–24. [in Russian]
89. Тарасова Л.В., Трухан Д.И. Лекарственная безопасность в гастроэнтерологии. Эксперим. и клин. гастроэнтерология. 2013; 4: 81–7. / Tarasova L.V., Trukhan D.I. Lekarstvennaia bezopasnost v gastroenterologii. Eksperim. i klin. gastroenterologiia. 2013; 4: 81–7. [in Russian]
90. Трухан Д.И, Тарасова Л.В. Лекарственная безопасность и рациональная фармакотерапия в гастроэнтерологической практике. Клин. перспективы гастроэнтерологии, гепатологии. 2013; 5: 9–16. / Trukhan D.I, Tarasova L.V. Lekarstvennaia bezopasnost i ratsionalnaia farmakoterapiia v gastroenterologicheskoi praktike. Klin. perspektivy gastroenterologii, gepatologii. 2013; 5: 9–16. [in Russian]

________________________________________________

1. Trukhan D.I. Vybor lekarstvennogo preparata s pozitsii ratsional'noi farmakoterapii. Consilium Medicum. 2013; 11: 45–9. [in Russian]
2. Trukhan D.I. Ratsional'naia farmakoterapiia v kardiologii skvoz' prizmu komorbidnosti i lekarstvennoi bezopasnosti. Handbook for Practitioners Doctors. 2015; 1: 26–31. [in Russian]
3. Lazebnik L.B. Polimorbidnost' i starenie. Novosti meditsiny i farmatsii. 2007; 1 (205). URL: http://archive.today/smbi [in Russian]
4. Belialov F.I. Dvenadtsat' tezisov komorbidnosti. Klin. meditsina. 2009; 12: 69–71. [in Russian]
5. Tsurko V.V. Dorsopatiia u pozhilykh: patobiologiia i kompleksnaia terapiia v klinicheskoi praktike. Terapevt. arkh. 2012; 10: 119–24. [in Russian]
6. Kotova O.V., Vorob'eva O.V. Osteokhondroz kak prichina dorsopatii. Consilium Medicum (Suppl. Neurology and Rheumatology). 2012; 2: 80–3. [in Russian]
7. Pimonova I. Lechenie dorsalgii na ambulatorno-poliklinicheskom etape v gorodskoi bol'nitse. Vrach. 2010; 3: 70–3. [in Russian]
8. Boitsov I.V. Dorsopatii sheinogo, grudnogo, poiasnichnogo otdelov pozvonochnika: osobennosti nevrologicheskikh oslozhnenii (obzor literatury). Sprav. vracha obshchei praktiki. 2013; 5: 73–8. [in Russian]
9. Trukhan D.I. Dorsalgia: actual aspects of treatment at the ambulatory-polyclinic stage. Handbook for Practitioners Doctors. 2017; 2: 78–83. [in Russian]
10. Manvelov L.S., Tiurnikov V.M. Poiasnichnye boli (etiologiia, klinika, diagnostika i lechenie). Rus. med. zhurn. 2009; 20: 1290–4. [in Russian]
11. Trukhan D.I. Musculoskeletal pain: actual aspects of treatment at the stage of primary medical care. Consilium Medicum. 2017; 19 (2): 129–135. [in Russian]
12. Podchufarova E.V. Skeletno-myshechnye boli v spine. RMZh. 2005; 12: 836–40. [in Russian]
13. Kotov A.S., Eliseev Iu.V. Poiasnichnaia bol'. Zhurn. nevrologii i psikhiatrii im. S.S.Korsakova. 2012; 5: 90–3. [in Russian]
14. Rachin A.P., Iakunin K.A., Demeshko A.V. Miofastsial'nyi bolevoi sindrom. M.: GEOTAR-Media, 2011. [in Russian]
15. Trevell Dzh. G., Simons D.G. Miofastsial'nye boli. T. 1. M.: Meditsina, 1989. [in Russian]
16. Voznesenskaia T.G. Miofastsial'nye bolevye sindromy. Consilium Medicum. 2002; 4 (8). URL: http://con-med.ru/magazines/consilium_medicum/consilium_medicum-08-2002/ [in Russian]
17. Vorobeva O.V. Skeletnaia muskulatura kak prichina lokal'nykh bolevykh sindromov. Consilium Medicum. 2012; 14 (2). URL: http://con-med.ru/magazines/consilium_medicum/consilium_medicum-02-2012/ [in Russian]
18. Nasonov E.L., Karateev A.E. Primenenie nesteroidnykh protivovospalitel'nykh preparatov. Klinicheskie rekomendatsii. RMZh. 2006; 25. URL: http://rmj.ru/articles_4309.htm [in Russian]
19. Trukhan D.I., Davydov E.L. Dorsalgia: topical aspects of treatment at stages of primary health care. Consilium Medicum. 2015; 17 (9): 82–7. [in Russian]
20. Revmatologiia. Natsionalnoe rukovodstvo. Pod red. E.L.Nasonova. M.: GEOTAR-Media, 2008 [in Russian]
21. Ratsionalnaia farmakoterapiia revmaticheskikh zabolevanii: Rukovodstvo dlia praktikuiushchikh vrachei. Pod obshch. red. V.A.Nasonovoi, E.L.Nasonova. M.: Litterra, 2007. [in Russian]
22. Nasonov E.L., Karateev A.E. Primenenie nesteroidnykh protivovospalitelnykh preparatov. Klinicheskie rekomendatsii. Rus. med. zhurn. 2006; 25: 1769–77. [in Russian]
23. Karateev A.E., Nasonov E.L. NPVP – assotsiirovannaia patologiia ZhKT: realnoe sostoianie del v Rossii. Rus. med. zhurn. 2006; 15: 1073–8. [in Russian]
24. Trukhan D.I., Viktorova I.A. Vnutrennie bolezni. Kardiologiia. Revmatologiia. M.: Med. informagentstvo, 2013. [in Russian]
25. Vertkin A.L., Nosova A.V., Alisov V.A., Zaichenko D.M. Vybor nesteroidnykh protivovospalitelnykh preparatov dlia kupirovaniia bolevogo sindroma v klinicheskoi praktike. Consilium Medicum. 2013; 15 (8): 63–7. [in Russian]
26. Trukhan D.I., Filimonov S.N., Viktorova I.A. Klinika, diagnostika i lechenie osnovnykh revmaticheskikh boleznei. SPb.: SpetsLit, 2014. [in Russian]
27. Lapina T.L. Gastropatiia, indutsirovannaia nesteroidnymi protivovospalitelnymi preparatami: puti resheniia problemy. Rus. med. zhurn. 2009; 2: 54–7. [in Russian]
28. Karateev A.E., Nasonov E.L., Iakhno N.N. i dr. Klinicheskie rekomendatsii «Ratsionalnoe primenenie nesteroidnykh protivovospalitelnykh preparatov (NPVP) v klinicheskoi praktike». Sovrem. revmatologiia. 2015; 9 (1): 4–23. [in Russian]
29. Roth SH. Nonsteroidal anti-inflammatory drug gastropathy: new avenues for safety. Clin Interv Aging 2011; 6: 125–31.
30. Roth SH. Coming to terms with nonsteroidal anti-inflammatory drug gastropathy. Drugs 2012; 72 (7): 873–9.
31. Trukhan D.I. Vybor nesteroidnogo protivovospalitelnogo preparata s pozitsii profilaktiki NPVP-gastropatii i lekarstvennoi bezopasnosti. Consilium Medicum. 2014; 16 (8): 14–9. [in Russian]
32. Trukhan D.I. Nonsteroidal anti-inflammatory drugs through the prism comorbidity and drug safety: in focus amtolmetin guatsil. Consilium Medicum. 2015; 17 (2): 27–33. [in Russian]
33. Vialov S.S. Protivovospalitelnaia terapiia i gastrotoksichnost: realnye vozmozhnosti profilaktiki. Rus. med. zhurn. 2014; 22. URL: http://rmj.ru/articles_9750.htm [in Russian]
34. Antman EM, Bennett JS, Daugherty A et al. Use of nonsteroidal antiinflammatory drugs. An Update for Clinicians. A Scientific Statement from the American Heart Association. Circulation 2007; 115: 1634–42.
35. Bhatt DL, Scheiman J, Abraham NS et al. ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. Circulation 2008; 118: 1894–909.
36. Lanza FL, Chan FK, Quigley EM. Guidelines for Prevention of NSAID-Related Ulcer Complications. Am J Gastroenterol 2009; 104: 728–38.
37. Chan FK, Abraham NS, Scheiman JM, Laine L. Management of Patients on Nonsteroidal Anti-inflammatory Drugs: A Clinical Practice Recommendation From the First International Working Party on Gastrointestinal and Cardiovascular Effects of Nonsteroidal Anti-inflammatory Drugs and Anti-platelet Agents. Am J Gastroenterol 2008; 103: 2908–18.
38. Pakhomova I.G. Novye vozmozhnosti v minimizatsii riska NPVP-indutsirovannykh gastropatii. Rus. med. zhurn. 2014; 10: 772–6. [in Russian]
39. Plotnikova E.Iu., Gracheva T.Iu. Erozivno-iazvennye porazheniia zheludochno-kishechnogo trakta i prostaglandiny: problemnyi duet. Handbook for Practitioners Doctors. 2016; 4: 32–7. [in Russian]
40. Rostom A, Moayyedi P, Hunt R. Canadian Association of Gastroenterology Consensus Group. Canadian consensus guidelines on long-term nonsteroidal anti-inflammatory drug therapy and the need for gastroprotection: benefits versus risks. Aliment Pharmacol Ther 2009; 29 (5): 481–96.
41. Scheiman JM, Hindley CE. Strategies to optimize treatment with NSAIDs in patients at risk for gastrointestinal and cardiovascular adverse events. Clin Ther 2010; 32 (4): 667–77.
42. Karateev A.E. Chto luchshe dlia profilaktiki NPVP-gastropatii: koksiby ili kombinatsiia «traditsionnykh» NPVP i gastroprotektora? Rus. med. zhurn. 2013; 13. URL: http://rmj.ru/articles_8770.htm [in Russian]
43. Popular heartburn medication may increase ischemic stroke risk. American Heart Association Meeting Report – Presentation: 391–Session: EP.AOS.765. URL: http://newsroom.heart.org/news/Xpopular-heartburn-medication-may-increase-ischemic-stroke-risk
44. Xie Y, Bowe B, Li T et al. Risk of death among users of Proton Pump Inhibitors: a longitudinal observational cohort study of United States veterans. BMJ Open 2017; 7 (6): e015735. DOI: 10.1136/bmjopen-2016-015735
45. Trukhan D.I., Tarasova L.V. Ratsionalnaia farmakoterapiia i lekarstvennaia bezopasnost v kardiologii. Handbook for Practitioners Doctors. 2013; 5: 21–6. [in Russian]
46. FDA Public Health Advisory: FDA announces important changes and additional warnings for COX-2 selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs). URL:http://www.fda.gov/ cder/drug/advisory/ COX2.htm
47. Pimanov S.I., Dikareva E.A., Makarenko E.V. Kak umenshit gastrointestinalnyi risk pri ispolzovanii nesteroidnykh protivovospalitelnykh preparatov? Consilium Medicum. 2014; 16 (2): 95–9. [in Russian]
48. Gislason G, Jacobsen S, Rasmussen J et al. Risk of death or reinfarction associated with the use of selective cyclooxygenase-2 inhibitors and nonselective nonsteroidal antiinflam-matory drugs after acute myocardial infarction. Circulation 2006; 113 (25): 2906–13.
49. Trelle S, Reichenbach S, Wandel S et al. Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. BMJ 2011; 342: 7086. URL: http://www.bmj.com/content/342/bmj.c7086
50. Mareev V.Iu., Ageev F.T., Arutiunov G.P. i dr. Natsionalnye rekomendatsii OSSN, RKO i RNMOT po diagnostike i lecheniiu KhSN (4-i peresmotr). Serdechnaia nedostatochnost. 2013; 7 (81): 379–472. [in Russian]
51. Kotova O.V., Akarachkova E.S. Mesto preparata nolodatak v lechenii boli v spine. Farmateka. 2015; 13 (306): 70–3. [in Russian]
52. Karateev A.E. What can be an alternative to non-steroidal anti-inflammatory drugs for the control of acute musculoskeletal pain in a patient with a history of myocardial infarction and gastrointestinal bleeding? Consilium Medicum. 2016; 18 (2): 141–9. [in Russian]
53. Magomedova M., Kamchatnov P. Effektivnost i bezopasnost lecheniia patsientov s poiasnichnoi boliu. Vrach. 2016; 3: 29–31. [in Russian]
54. Kotova O.V., Akarachkova E.S. Bol v shee: vozmozhnosti terapii. Terapiia. 2016; 2 (6): 70–5. [in Russian]
55. Podymova I.G., Danilov A.B. Features of treatment of pain in the lower back in patients with contraindications for nonsteroidal anti-inflammatory drugs. Consilium Medicum. 2016; 18 (2): 50–2. [in Russian]
56. Kamchatnov P.R., Magomedova M.A., Chugunov A.V. Problema effektivnosti i bezopasnosti lecheniia patsienta s poiasnichnoi boliu. Terapiia. 2016; 1: 75–81. [in Russian]
57. Azimova Iu.E. Bol v spine: bremia soputstvuiushchikh zabolevanii i podbor effektivnoi terapii. Terapiia. 2017; 1: 144–8. [in Russian]
58. Kamchatnov P.R., Khanmurzaeva N.B., Khanmurzaeva S.B. Nolodotak (flupirtin) v lechenii patsientov s dorsopatiei. Terapiia. 2017; 3: 76–83. [in Russian]
59. Ueberall MА, Mueller-Schwefe GН, Terhaag B. Efficacy and tolerability of flupirtine in subacute / chronic musculoskeletal pain – results of a patient level, pooled reanalysis of randomized, doubleblind, controlled trials. Int J Clin Pharmacol Ther 2011; 49: 637–47.
60. Jakob R, Krieglstein J. Influence of flupirtine on a G-protein coupled inwardly rectifying potassium current in hippocampal neurons. Br J Pharmacol 1997; 122: 1333–8.
61. Kornhuber J, Bleich S, Wiltfang J et al. Flupirtine shows functional NMDA receptor antagonism by enhancing Mg+ block via activation of voltage independent potassium channels. J Neural Transm 1999; 106 (9–10): 857–67.
62. Wörz R, Müller-Schwefe G, Stroehmann I et al. Back pain: Guidelines for drug therapy. Fortschr Med 2000; 142 (5): 27–33.
63. Szelenyi I. Flupirtine, a re-discovered drug, revisited. Inflamm Res 2013 Mar; 62 (3): 251–8.
64. Wörz R, Bolten W, Heller B et al. Flupirtine in comparison with chlormezanone in chronic musculoskeletal back pain. Results of a multicenter randomized double-blind study. Fortschr Med 1996; 114 (35–36): 500–4.
65. Perovic S, Pialoglou P, Schroder HC et al. Flupirtine increases the levels of glutathione and Bc1–2 in hNT (human Ntera/D1) neurons: mode of action of the drug-mediated anti-apoptotic effect. Eur J Pharmacol 1996; 317 (1): 157–64.
66. Klawe C, Maschke M. Flupirtine: pharmacology and clinical applications of a nonopioid analgesic and potentially neuroprotective compound. Expert Opin Pharmacother 2009; 10 (9): 1495–500.
67. Devulder J. Flupirtine in pain management: pharmacological properties and clinical use. CNS Drugs 2010; 24 (10): 867–81.
68. Raffa RB, Pergolizzi JV Jr. The evolving understanding of the analgesic mechanism of action of flupirtine. J Clin Pharm Ther 2012; 37 (1): 4–6.
69. Mueller-Schwefe G. Flupirtine in acute and chronic pain associated with muscle tenseness. Results of a postmarket surveillance study. Fortschr Med Orig 2003; 121 (1): 11–8.
70. Ringe JD et al. Analgesic Efficacy of Flupirtine in Primary Care of Patients with Osteoporosis Related Pain. A multivariate analysis. Arzneimittelforschung 2003; 53 (7): 496–502.
71. Levin Ia.I., Strygin K.N., Dobrovolskaia L.E. Katadolon v lechenii boli v spine. Lechenie nervnykh boleznei. 2005; 6 (3): 12–7. [in Russian]
72. Kamchatnov P.R., Batysheva T.T., Ganzhula P.A. i dr. Primenenie katadolona u bolnykh so spondilogennoi dorsalgiei. Zhurn. nevrologii i psikhiatrii im. S.S.Korsakova. 2006; 106 (11): 46–8. [in Russian]
73. Erdes Sh., Galushko E., Zotkin E. i dr. Effektivnost katadolona (flupirtina) u patsientov s boliami v nizhnei chasti spiny. Vrach. 2007; 5: 56–9. [in Russian]
74. Alekseev V.V., Rachin A.P., Podchufarova E.V. Flupirtin (Katadolon) – nestandartnyi podkhod v terapii boli. Nevrol. i revmatologiia. 2009; 2: 50–3. [in Russian]
75. Danilov A.B., Nikolaeva N.S. Effektivnost novoi formy flupirtina (Katadolona forte) v lechenii ostroi boli v spine. Managepain. 2013; 1: 44–8. [in Russian]
76. Yadav G, Behera SS, Das SK et al. Role of flupirtine as a preemptive analgesic in patients undergoing laparoscopic cholecystectomy. J Anaesthesiol Clin Pharmacol 2015; 31 (2): 169–73.
77. Ueberall MA, Essner U, Müller-Schwefe GH. 2-week efficacy and tolerability of flupirtine MR and diclofenac in patients with acute low/back pain-results of a post-hoc subgroup analysis of patient-level data from four non-interventional studies. MMW Fortschr Med 2013; 155 (Suppl. 4): 115–23.
78. Li C, Ni J, Wang Z et al. Analgesic efficacy and tolerability of flupirtine vs. tramadol in patients with subacute low back pain: a double-blind multicentre trial. Curr Med Res Opin 2008; 24 (12): 3523–30.
79. Uberall MA, Mueller-Schwefe GH, Terhaag B. Efficacy and safety of flupirtine modified release for the management of moderate to severe chronic low back pain: results of SUPREME, a prospective randomized, double-blind, placebo- and active-controlled parallel-group phase IV study. Curr Med Res Opin 2012; 28 (10): 1617–34.
80. Rachin A.P. Desiat dokazatelstv uspeshnogo primeneniia flupirtina (katadolona) pri boliakh v nizhnei chasti spiny. Lechenie nervnykh boleznei. 2007; 2: 35–9. [in Russian]
81. Restrictions in the use of flupirtine-containing medicines – CMDh endorses PRAC recommendation. Press release. 28/06/2013. URL: http://www.ema.europa.eu/ema/ index.jsp curl=pages/news_and_events/news/2013/06/news_detail_001831.jsp&mid=WC0b01ac058004d5c1
82. Restrictions in the use of flupirtine-containing medicines. 13 September 2013. EMA/563900/ 2013. URL: http://www.ema.europa.eu/docs/en_GB/document_library/ Referrals_document/Flupirtine-containing_medicines/European_Commission_final_decision/ WC500155310.pdf
83. Harish S, Bhuvana K, Bengalorkar GM, Kumar T. Flupirtine: Clinical pharmacology. J Anaesth Clin Pharmacol 2012; 28: 172–7.
84. Treudler R, Pohle K, Simon JC. Flupirtine is a safe alternative drug in patients with hypersensitivity to NSAIDs. Eur J Clin Pharmacol 2011; 67 (9): 961–3.
85. Flupirtine (флупиртин). URL: https://www.vidal.ru/drugs/molecule/1338 / Flupirtine (flupirtin). URL: https://www.vidal.ru/drugs/molecule/1338 [in Russian]
86. Wörz R. Long-term-treatment of chronic pain patients with flupirtine – on hepatotoxicity and persistent effectiveness from 7 months to 22 years. MMW Fortschr Med 2014; 156 (Suppl. 4): 127–34.
87. Nicoletti P, Werk A, Sawle A et al. International Drug-induced Liver Injury Consortium. HLA-DRB1*16: 01-DQB1*05: 02 is a novel genetic risk factor for flupirtine-induced liver injury. Pharmacogenet Genomics 2016; 26 (5): 218–24.
88. Trukhan D.I. Ratsionalnaia farmakoterapiia v gastroenterologii. Handbook for Practitioners Doctors. 2012; 10: 18–24. [in Russian]
89. Tarasova L.V., Trukhan D.I. Lekarstvennaia bezopasnost v gastroenterologii. Eksperim. i klin. gastroenterologiia. 2013; 4: 81–7. [in Russian]
90. Trukhan D.I, Tarasova L.V. Lekarstvennaia bezopasnost i ratsionalnaia farmakoterapiia v gastroenterologicheskoi praktike. Klin. perspektivy gastroenterologii, gepatologii. 2013; 5: 9–16. [in Russian]

 

Д.И.Трухан

ФГБОУ ВО «Омский государственный медицинский университет» Минздрава России. 644099, Россия, Омск, ул. Ленина, д. 12
dmitry_trukhan@mail.ru

________________________________________________

D.I.Trukhan

Omsk State Medical University of the Ministry of Health of the Russian Federation. 644099, Russian Federation, Omsk, ul. Lenina, d. 12
dmitry_trukhan@mail.ru