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Клинический опыт применения аминокислот L-аргинина и L-карнитина в лечении гнездной алопеции
Клинический опыт применения аминокислот L-аргинина и L-карнитина в лечении гнездной алопеции
Балтабаев А.М., Ниязов Б.С., Балтабаев М.К. Клинический опыт применения аминокислот L-аргинина и L-карнитина в лечении гнездной алопеции. Дерматология (Прил. к журн. Consilium Medicum). 2018; 1: 18–25.
DOI: 10.26442/2414-3537_2018.1.18-25
DOI: 10.26442/2414-3537_2018.1.18-25
DOI: 10.26442/2414-3537_2018.1.18-25
________________________________________________
DOI: 10.26442/2414-3537_2018.1.18-25
Материалы доступны только для специалистов сферы здравоохранения.
Чтобы посмотреть материал полностью
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Аннотация
Гнездная алопеция – иммунозависимое нерубцовое выпадение волос, сопровождающееся выработкой антител к антигенам волосяного фолликула с последующим прерыванием фазы роста и выпадением стержня волоса. В исследовании получен клинический опыт применения аминокислот L-аргинина и L-карнитина как стимуляторов возобновления роста волос у пациентов с гнездной алопецией.
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Полный текст
Список литературы
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22. Lucotti P, Monti L, Setola E et al. Oral L-arginine supplementation improves endothelial function and ameliorates insulin sensitivity and inflammation in cardiopathic nondiabetic patients after an aortocoronary bypass. Metabolism 2009; 58 (9): 1270–6.
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24. Гуревич М.А., Стуров Н.В. Дефицит оксида азота и поддержание сосудистого гомеостаза: роль мононитратов и проблемы цитопротекции. Трудный пациент. 2006; 3: 23–9. / Gurevich M.A., Sturov N.V. Defitsit oksida azota i podderzhanie sosudistogo gomeostaza: rol' mononitratov i problemy tsitoprotektsii. Trudnyi patsient. 2006; 3: 23–9. [in Russian]
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26. Yi J, Böger RH. The pharmacodynamics of L-arginine. J Nutr 2007; 137: 1650S–1655S.
27. Dulak J, Józkowicz A, Dembinska-Kiec A et al. Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2000; 20: 659–66.
28. Arduini A. Carnitine and its acyl esters as secondary antioxidants? Am Heart J 1992; 123: 1726–7.
29. Xin Zhou, Fang Liu, Suodi Zhai M. Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review. Asia Pac J Clin Nutr 2007; 16 (Suppl. 1): 383–90.
30. Foitzik K, Hoting E, Förster T et al. L-carnitine-L-tartrate promotes human hair growth in vitro. Exp Dermatol 2007; 16 (11): 936–45.
31. Балтабаев М.К., Балтабаев А.М. Способ лечения алопеции. Патент на изобретение № 025550 Евразийская Патентная Организация, Евразийское Патентное Ведомство, Москва, от 30.01.2017. / Baltabaev M.K., Baltabaev A.M. Sposob lecheniia alopetsii. Patent na izobretenie № 025550 Evraziiskaia Patentnaia Organizatsiia, Evraziiskoe Patentnoe Vedomstvo, Moskva, ot 30.01.2017. [in Russian]
32. Olsen EA. Investigative guidelines for alopecia areata. Dermatol Ther 2011; 24: 311–9.
2. Serbina I.M. Otsenka stepeni tiazhesti gnezdnoi alopetsii. Dermatologіia ta venerologіia. 2014; 4 (66): 65–71. [in Russian]
3. Safavi K. Prevalence of alopecia areata in the First National Health and Nutrition Examination Survey. Arch Dermatol 1992; 128: 702.
4. Gilhar A, Etzioni A, Paus R. Alopecia areata. N Engl J Med 2012; 366: 1515–25.
5. Wahl SM, Wen J, Moutsopoulos N. TGF-beta: a mobile purveyor of immune privilege. Immunol Rev 2006; 213: 213–27.
6. Gilhar A, Paus R, Kalish RS. Lymphocytes, neuropeptides, and genes involved in alopecia areata. J Clin Invest 2009; 117: 2019–27.
7. Kinori M et al. Exp Dermatol 2012; 21: 223–26.
8. Christoph T et al. The human hair follicle immune system: cellular. Br J Dermatol 2000; 142: 862–73.
9. Verkhogliad I.V. Immunologicheskoe obosnovanie patogeneticheskogo primeneniia eksimernogo lazera pri gnezdnoi alopetsii. Avtoref. dis. … d-ra med. nauk. M., 2010. [in Russian]
10. Gadzhigoroeva A.G. Lechenie bol'nykh s razlichnymi klinicheskimi variantami gnezdnoi alopetsii s uchetom patogeneticheskikh osobennostei zabolevaniia. Avtoref. dis. d-ra med. nauk. M., 2015. [in Russian]
11. Shapiro J, Lui H, Tron V et al. Systemic cyclosporine and low-dose prednisone in the treatment of chronic severe alopecia areata: a clinical and immunopathologic evaluation. J Am Acad Dermatol 1997; 36: 114–17.
12. Joly P. The use of methotrexate alone or in combination with low doses of oral corticosteroids in the treatment of alopecia totalis or universalis. J Am Acad Dermatol 2006; 55: 632–6.
13. Tosti A, Piraccini BM, Pazzaglia M et al. Clobetasol propionate 0.05% under occlusion in the treatment of alopecia totalis universalis. J Am Acad Dermatol 2003; 49: 96–8.
14. Olsen EA, Carson SC, Turney EA. Systemic steroids with or without 2% topical minoxidil in the treatment of alopecia areata. Arch Dermatol 1992; 128: 1467–73.
15. Skripkin Iu.K., Vinokurov I.N. Kompleksnoe lechenie kortikosteroidami i anabolicheskimi gormonami bol'nykh s tiazhelymi formami gnezdnoi alopetsii. Sov. med. 1973; 2: 121–2. [in Russian]
16. Kozlowska U, Blume-Peytavi U, Kodelja V et al. Expression of vascular endothelial growth factor (VEGF) in various compartments of the human hair follicle. Arch Dermatol Res 1998; 290 (12): 661–8.
17. Peus D, Pittelkow MR. Growth factors in hair organ development and the hair growth cycle. Dermatol Clin 1996; 14 (4): 559–72.
18. Ozeki M, Tabata Y. In vivo promoted growth of mice hair follicles by the controlled release of growth factors. Biomaterials 2003; 24: 2387–94. DOI: 10.1016/S0142-9612(03)00045-0.
19. Kim MJ, Lim C, Lee JY et al. Visible-to-near IR quantum dot-based hypermulticolor high-content screening of herbal medicines for the efficacy monitoring of hair growth promoting and hair loss inhibition. J Biomol Screen 2013; 18: 462–73. DOI: 10.1177/1087057112464574.
20. Messenger AG, Rundegren J. Minoxidil: mechanisms of action on hairgrowth. Br J Dermatol 2004; 150 (2): 186–94.
21. Ganzetti G, Campanati A, Simonetti O et al. Videocapillaroscopic pattern of alopecia areata before and after diphenylciclopropenonetreatment. Int J Immunopathol Pharmacol 2011; 24 (4): 1087–91.
22. Lucotti P, Monti L, Setola E et al. Oral L-arginine supplementation improves endothelial function and ameliorates insulin sensitivity and inflammation in cardiopathic nondiabetic patients after an aortocoronary bypass. Metabolism 2009; 58 (9): 1270–6.
23. Kawano H, Motoyama T, Hirai N et al. Endothelial dysfunction in hypercholesterolemia is improved by L-arginine administration: possible role of oxidative stress. Atherosclerosis 2002; 161 (2): 375–80.
24. Gurevich M.A., Sturov N.V. Defitsit oksida azota i podderzhanie sosudistogo gomeostaza: rol' mononitratov i problemy tsitoprotektsii. Trudnyi patsient. 2006; 3: 23–9. [in Russian]
25. El'skii V.N., Vatutin N.T., Kalinkina N.V., Salakhova A.M. Rol' disfunktsii endoteliia v geneze serdechno-sosudistykh zabolevanii. Zhurn. AMN Ukraїni. 2008; 14 (1): 51–62. [in Russian]
26. Yi J, Böger RH. The pharmacodynamics of L-arginine. J Nutr 2007; 137: 1650S–1655S.
27. Dulak J, Józkowicz A, Dembinska-Kiec A et al. Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2000; 20: 659–66.
28. Arduini A. Carnitine and its acyl esters as secondary antioxidants? Am Heart J 1992; 123: 1726–7.
29. Xin Zhou, Fang Liu, Suodi Zhai M. Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review. Asia Pac J Clin Nutr 2007; 16 (Suppl. 1): 383–90.
30. Foitzik K, Hoting E, Förster T et al. L-carnitine-L-tartrate promotes human hair growth in vitro. Exp Dermatol 2007; 16 (11): 936–45.
31. Baltabaev M.K., Baltabaev A.M. Sposob lecheniia alopetsii. Patent na izobretenie № 025550 Evraziiskaia Patentnaia Organizatsiia, Evraziiskoe Patentnoe Vedomstvo, Moskva, ot 30.01.2017. [in Russian]
32. Olsen EA. Investigative guidelines for alopecia areata. Dermatol Ther 2011; 24: 311–9.
2. Сербина И.М. Оценка степени тяжести гнездной алопеции. Дерматологія та венерологія. 2014; 4 (66): 65–71. / Serbina I.M. Otsenka stepeni tiazhesti gnezdnoi alopetsii. Dermatologіia ta venerologіia. 2014; 4 (66): 65–71. [in Russian]
3. Safavi K. Prevalence of alopecia areata in the First National Health and Nutrition Examination Survey. Arch Dermatol 1992; 128: 702.
4. Gilhar A, Etzioni A, Paus R. Alopecia areata. N Engl J Med 2012; 366: 1515–25.
5. Wahl SM, Wen J, Moutsopoulos N. TGF-beta: a mobile purveyor of immune privilege. Immunol Rev 2006; 213: 213–27.
6. Gilhar A, Paus R, Kalish RS. Lymphocytes, neuropeptides, and genes involved in alopecia areata. J Clin Invest 2009; 117: 2019–27.
7. Kinori M et al. Exp Dermatol 2012; 21: 223–26.
8. Christoph T et al. The human hair follicle immune system: cellular. Br J Dermatol 2000; 142: 862–73.
9. Верхогляд И.В. Иммунологическое обоснование патогенетического применения эксимерного лазера при гнездной алопеции. Автореф. дис. … д-ра мед. наук. М., 2010. / Verkhogliad I.V. Immunologicheskoe obosnovanie patogeneticheskogo primeneniia eksimernogo lazera pri gnezdnoi alopetsii. Avtoref. dis. … d-ra med. nauk. M., 2010. [in Russian]
10. Гаджигороева А.Г. Лечение больных с различными клиническими вариантами гнездной алопеции с учетом патогенетических особенностей заболевания. Автореф. дис. д-ра мед. наук. М., 2015. / Gadzhigoroeva A.G. Lechenie bol'nykh s razlichnymi klinicheskimi variantami gnezdnoi alopetsii s uchetom patogeneticheskikh osobennostei zabolevaniia. Avtoref. dis. d-ra med. nauk. M., 2015. [in Russian]
11. Shapiro J, Lui H, Tron V et al. Systemic cyclosporine and low-dose prednisone in the treatment of chronic severe alopecia areata: a clinical and immunopathologic evaluation. J Am Acad Dermatol 1997; 36: 114–17.
12. Joly P. The use of methotrexate alone or in combination with low doses of oral corticosteroids in the treatment of alopecia totalis or universalis. J Am Acad Dermatol 2006; 55: 632–6.
13. Tosti A, Piraccini BM, Pazzaglia M et al. Clobetasol propionate 0.05% under occlusion in the treatment of alopecia totalis universalis. J Am Acad Dermatol 2003; 49: 96–8.
14. Olsen EA, Carson SC, Turney EA. Systemic steroids with or without 2% topical minoxidil in the treatment of alopecia areata. Arch Dermatol 1992; 128: 1467–73.
15. Скрипкин Ю.К., Винокуров И.Н. Комплексное лечение кортикостероидами и анаболическими гормонами больных с тяжелыми формами гнездной алопеции. Сов. мед. 1973; 2: 121–2. / Skripkin Iu.K., Vinokurov I.N. Kompleksnoe lechenie kortikosteroidami i anabolicheskimi gormonami bol'nykh s tiazhelymi formami gnezdnoi alopetsii. Sov. med. 1973; 2: 121–2. [in Russian]
16. Kozlowska U, Blume-Peytavi U, Kodelja V et al. Expression of vascular endothelial growth factor (VEGF) in various compartments of the human hair follicle. Arch Dermatol Res 1998; 290 (12): 661–8.
17. Peus D, Pittelkow MR. Growth factors in hair organ development and the hair growth cycle. Dermatol Clin 1996; 14 (4): 559–72.
18. Ozeki M, Tabata Y. In vivo promoted growth of mice hair follicles by the controlled release of growth factors. Biomaterials 2003; 24: 2387–94. DOI: 10.1016/S0142-9612(03)00045-0.
19. Kim MJ, Lim C, Lee JY et al. Visible-to-near IR quantum dot-based hypermulticolor high-content screening of herbal medicines for the efficacy monitoring of hair growth promoting and hair loss inhibition. J Biomol Screen 2013; 18: 462–73. DOI: 10.1177/1087057112464574.
20. Messenger AG, Rundegren J. Minoxidil: mechanisms of action on hairgrowth. Br J Dermatol 2004; 150 (2): 186–94.
21. Ganzetti G, Campanati A, Simonetti O et al. Videocapillaroscopic pattern of alopecia areata before and after diphenylciclopropenonetreatment. Int J Immunopathol Pharmacol 2011; 24 (4): 1087–91.
22. Lucotti P, Monti L, Setola E et al. Oral L-arginine supplementation improves endothelial function and ameliorates insulin sensitivity and inflammation in cardiopathic nondiabetic patients after an aortocoronary bypass. Metabolism 2009; 58 (9): 1270–6.
23. Kawano H, Motoyama T, Hirai N et al. Endothelial dysfunction in hypercholesterolemia is improved by L-arginine administration: possible role of oxidative stress. Atherosclerosis 2002; 161 (2): 375–80.
24. Гуревич М.А., Стуров Н.В. Дефицит оксида азота и поддержание сосудистого гомеостаза: роль мононитратов и проблемы цитопротекции. Трудный пациент. 2006; 3: 23–9. / Gurevich M.A., Sturov N.V. Defitsit oksida azota i podderzhanie sosudistogo gomeostaza: rol' mononitratov i problemy tsitoprotektsii. Trudnyi patsient. 2006; 3: 23–9. [in Russian]
25. Ельский В.Н., Ватутин Н.Т., Калинкина Н.В., Салахова А.М. Роль дисфункции эндотелия в генезе сердечно-сосудистых заболеваний. Журн. АМН України. 2008; 14 (1): 51–62. / El'skii V.N., Vatutin N.T., Kalinkina N.V., Salakhova A.M. Rol' disfunktsii endoteliia v geneze serdechno-sosudistykh zabolevanii. Zhurn. AMN Ukraїni. 2008; 14 (1): 51–62. [in Russian]
26. Yi J, Böger RH. The pharmacodynamics of L-arginine. J Nutr 2007; 137: 1650S–1655S.
27. Dulak J, Józkowicz A, Dembinska-Kiec A et al. Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2000; 20: 659–66.
28. Arduini A. Carnitine and its acyl esters as secondary antioxidants? Am Heart J 1992; 123: 1726–7.
29. Xin Zhou, Fang Liu, Suodi Zhai M. Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review. Asia Pac J Clin Nutr 2007; 16 (Suppl. 1): 383–90.
30. Foitzik K, Hoting E, Förster T et al. L-carnitine-L-tartrate promotes human hair growth in vitro. Exp Dermatol 2007; 16 (11): 936–45.
31. Балтабаев М.К., Балтабаев А.М. Способ лечения алопеции. Патент на изобретение № 025550 Евразийская Патентная Организация, Евразийское Патентное Ведомство, Москва, от 30.01.2017. / Baltabaev M.K., Baltabaev A.M. Sposob lecheniia alopetsii. Patent na izobretenie № 025550 Evraziiskaia Patentnaia Organizatsiia, Evraziiskoe Patentnoe Vedomstvo, Moskva, ot 30.01.2017. [in Russian]
32. Olsen EA. Investigative guidelines for alopecia areata. Dermatol Ther 2011; 24: 311–9.
________________________________________________
2. Serbina I.M. Otsenka stepeni tiazhesti gnezdnoi alopetsii. Dermatologіia ta venerologіia. 2014; 4 (66): 65–71. [in Russian]
3. Safavi K. Prevalence of alopecia areata in the First National Health and Nutrition Examination Survey. Arch Dermatol 1992; 128: 702.
4. Gilhar A, Etzioni A, Paus R. Alopecia areata. N Engl J Med 2012; 366: 1515–25.
5. Wahl SM, Wen J, Moutsopoulos N. TGF-beta: a mobile purveyor of immune privilege. Immunol Rev 2006; 213: 213–27.
6. Gilhar A, Paus R, Kalish RS. Lymphocytes, neuropeptides, and genes involved in alopecia areata. J Clin Invest 2009; 117: 2019–27.
7. Kinori M et al. Exp Dermatol 2012; 21: 223–26.
8. Christoph T et al. The human hair follicle immune system: cellular. Br J Dermatol 2000; 142: 862–73.
9. Verkhogliad I.V. Immunologicheskoe obosnovanie patogeneticheskogo primeneniia eksimernogo lazera pri gnezdnoi alopetsii. Avtoref. dis. … d-ra med. nauk. M., 2010. [in Russian]
10. Gadzhigoroeva A.G. Lechenie bol'nykh s razlichnymi klinicheskimi variantami gnezdnoi alopetsii s uchetom patogeneticheskikh osobennostei zabolevaniia. Avtoref. dis. d-ra med. nauk. M., 2015. [in Russian]
11. Shapiro J, Lui H, Tron V et al. Systemic cyclosporine and low-dose prednisone in the treatment of chronic severe alopecia areata: a clinical and immunopathologic evaluation. J Am Acad Dermatol 1997; 36: 114–17.
12. Joly P. The use of methotrexate alone or in combination with low doses of oral corticosteroids in the treatment of alopecia totalis or universalis. J Am Acad Dermatol 2006; 55: 632–6.
13. Tosti A, Piraccini BM, Pazzaglia M et al. Clobetasol propionate 0.05% under occlusion in the treatment of alopecia totalis universalis. J Am Acad Dermatol 2003; 49: 96–8.
14. Olsen EA, Carson SC, Turney EA. Systemic steroids with or without 2% topical minoxidil in the treatment of alopecia areata. Arch Dermatol 1992; 128: 1467–73.
15. Skripkin Iu.K., Vinokurov I.N. Kompleksnoe lechenie kortikosteroidami i anabolicheskimi gormonami bol'nykh s tiazhelymi formami gnezdnoi alopetsii. Sov. med. 1973; 2: 121–2. [in Russian]
16. Kozlowska U, Blume-Peytavi U, Kodelja V et al. Expression of vascular endothelial growth factor (VEGF) in various compartments of the human hair follicle. Arch Dermatol Res 1998; 290 (12): 661–8.
17. Peus D, Pittelkow MR. Growth factors in hair organ development and the hair growth cycle. Dermatol Clin 1996; 14 (4): 559–72.
18. Ozeki M, Tabata Y. In vivo promoted growth of mice hair follicles by the controlled release of growth factors. Biomaterials 2003; 24: 2387–94. DOI: 10.1016/S0142-9612(03)00045-0.
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Авторы
А.М.Балтабаев*1, Б.С.Ниязов2, М.К.Балтабаев1
1. Кыргызско-российский славянский университет.
720000, Кыргызстан, Бишкек, ул. Киевская, д. 44;
2. Кыргызский государственный медицинский институт переподготовки и повышения квалификации.
720040, Кыргызстан, Бишкек, ул. Боконбаева, д. 144А
*alijon.baltabayev@gmail.com
1. Kyrgyz Russian Slavic University. 720000, Kyrgyzstan, Bishkek,
ul. Kievskaia, d. 44;
2. Kyrgyz State Medical Institute of Retraining and Advanced training. 720040, Kyrgyzstan, Bishkek, ul. Bokonbaeva, d. 144А
*alijon.baltabayev@gmail.com
1. Кыргызско-российский славянский университет.
720000, Кыргызстан, Бишкек, ул. Киевская, д. 44;
2. Кыргызский государственный медицинский институт переподготовки и повышения квалификации.
720040, Кыргызстан, Бишкек, ул. Боконбаева, д. 144А
*alijon.baltabayev@gmail.com
________________________________________________
1. Kyrgyz Russian Slavic University. 720000, Kyrgyzstan, Bishkek,
ul. Kievskaia, d. 44;
2. Kyrgyz State Medical Institute of Retraining and Advanced training. 720040, Kyrgyzstan, Bishkek, ul. Bokonbaeva, d. 144А
*alijon.baltabayev@gmail.com
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