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Влияние COVID-19 на фертильность. Какие предпосылки и риски возникнут в новой реальности?
Влияние COVID-19 на фертильность. Какие предпосылки и риски возникнут в новой реальности?
Попова А.Ю., Гамидов С.И., Овчинников Р.И. и др. Влияние COVID-19 на фертильность. Какие предпосылки и риски возникнут в новой реальности? Consilium Medicum. 2020; 22 (6): 73–77. DOI: 10.26442/20751753.2020.6.200355
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Аннотация
Новое коронавирусное заболевание 2019 г. (COVID-19), вызванное SARS-CoV-2 (тяжелый острый респираторный синдром, связанный с коронавирусом-2), вызывает серьезную обеспокоенность в области общественного здравоохранения во всем мире. Вопрос о том, может ли SARS-CoV-2 проникать в ткань яичка и/или сперму, в настоящее время остается без ответа. Также повышает ли присутствие вирусов в сперме вероятность того, что болезнь может передаваться половым путем? В настоящее время много вопросов возникает у специалистов, занимающихся бесплодием. Но, к сожалению, на сегодняшний день достоверных данных нет. В этой статье анализируются имеющиеся работы по влиянию COVID-19 на репродуктивную функцию мужчин.
Ключевые слова: COVID-19, SARS-CoV-2, бесплодие, ткань яичка, ангиотензинпревращающий фермент-2.
Key words: COVID-19, SARS-CoV-2, infertility, testicular tissue, angiotensin-converting enzyme 2.
Ключевые слова: COVID-19, SARS-CoV-2, бесплодие, ткань яичка, ангиотензинпревращающий фермент-2.
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Key words: COVID-19, SARS-CoV-2, infertility, testicular tissue, angiotensin-converting enzyme 2.
Полный текст
Список литературы
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19. Chan JF, Yuan S, Kok KH et al. A Familial Cluster of Pneumonia Associated with the 2019 Novel Coronavirus Indicating Person-to-Person Transmission: A Study of a Family Cluster. Lancet 2020; 395: 514–23. DOI: 10.1016/S0140-6736(20)30154-9
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2. Mungroo MR, Khan NA, Siddiqui R. Novel Coronavirus: Current Understanding of Clinical Features, Diagnosis, Pathogenesis, and Treatment Options. Pathogens 2020; 9: E297. DOI: 10.3390/pathogens9040297
3. Zhu N, Zhang D, Wang W et al, China Novel Coronavirus Investigating and Research Team. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med 2020; 382: 727–33. DOI: 10.1056/NEJMoa2001017
4. Jin Y, Yang H, Ji W et al. Virology, Epidemiology, Pathogenesis, and Control of COVID-19. Viruses 2020; 12: E372. DOI: 10.3390/v12040372
5. Thorlund K, Dron L, Park J et al. A Real-Time Dashboard of Clinical Trials for COVID-19. Lancet Digit Health 2020. DOI: 10.1016/S2589-7500(20)30086-8
6. Hick JL, Biddinger PD. Novel Coronavirus and Old Lessons – Preparing the Health System for the Pandemic. N Engl J Med 2020; 382: e55. DOI: 10.1056/NEJMp2005118
7. Fauci AS, Lane HC, Redfield RR. Covid-19 – Navigating the Uncharted. N Engl J Med 2020; 382: 1268–9. DOI: 10.1056/NEJMe2002387
8. Cardona Maya WD, Du Plessis SS, Velilla PA. SARS-CoV-2 and the Testis: Similarity with Other Viruses and Routes of Infection. Reprod Biomed Online 2020. DOI: 10.1016/j.rbmo.2020.04.009. S1472648320301887
9. Wang Z, Xu X. ScRNA-Seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells. Cells 2020; 9: 920. DOI: 10.3390/cells9040920
10. Esteves SC, Lombardo F, Garrido N et al. SARS-CoV-2 Pandemic and Repercussions for Male Infertility Patients: A Proposal for the Individualized Provision of Andrological Services. Andrology 2020. DOI: 10.1111/andr.12809
11. Stanley KE, Thomas E, Leaver M, Wells D. Coronavirus Disease (COVID-19) and Fertility: Viral Host Entry Protein Expression in Male and Female Reproductive Tissues. Fertil Steril 2020. DOI: 10.1016/j.fertnstert.2020.05.001
12. Monteleone PA, Nakano M, Lazar V et al. A review of initial data on pregnancy during the COVID-19 outbreak: implications for assisted reproductive treatments. JBRA Assist Reprod 2020; 24: 219–25. DOI: 10.5935/1518-0557.20200030
13. Zhou G, Chen S, Chen Z. Advances in COVID-19: The Virus, the Pathogenesis, and Evidence-Based Control and Therapeutic Strategies. Front Med 2020; 14: 117–25. DOI: 10.1007/s11684-020-0773-x
14. Fan C, Li K, Ding Y et al. ACE2 expression in kidney and testis may cause kidney and testis damage after 2019-nCoV infection. MedRxiv 2020.
15. Xu J, Qi L, Chi X et al. Orchitis: a complication of severe acute respiratory syndrome (SARS)1. Biol Reprod 2006; 74: 410–6.
16. Zhao J, Zhou G, Sun Y. SARS coronavirus could cause multi-organ infection. Med J Chinese People’s Liberation Army 2003; 28: 697–8.
17. Pan F, Xiao X, Guo et al. No Evidence of SARS-CoV-2 in Semen of Males Recovering from COVID-19. Fertil Steril 2020. DOI: 10.1016/j.fertnstert.2020.04.024. S0015028220303848
18. Song C, Wang Y, Li W et al. Absence of 2019 Novel Coronavirus in Semen and Testes of COVID-19 Patients. Biol Reprod 2020. DOI: 10.1093/biolre/ioaa050
19. Chan JF, Yuan S, Kok KH et al. A Familial Cluster of Pneumonia Associated with the 2019 Novel Coronavirus Indicating Person-to-Person Transmission: A Study of a Family Cluster. Lancet 2020; 395: 514–23. DOI: 10.1016/S0140-6736(20)30154-9
20. Li D, Jin M, Bao P et al. Clinical Characteristics and Results of Semen Tests Among Men With Coronavirus Disease 2019. JAMA Netw Open 2020; 3: e208292. DOI: 10.1001/jamanetworkopen.2020.8292
21. Segars J, Katler Q, McQueen DB et al. for the ASRM Coronavirus/COVID-19 Task Force. Fertil Steril 2020.
2. Mungroo MR, Khan NA, Siddiqui R. Novel Coronavirus: Current Understanding of Clinical Features, Diagnosis, Pathogenesis, and Treatment Options. Pathogens 2020; 9: E297. DOI: 10.3390/pathogens9040297
3. Zhu N, Zhang D, Wang W et al, China Novel Coronavirus Investigating and Research Team. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med 2020; 382: 727–33. DOI: 10.1056/NEJMoa2001017
4. Jin Y, Yang H, Ji W et al. Virology, Epidemiology, Pathogenesis, and Control of COVID-19. Viruses 2020; 12: E372. DOI: 10.3390/v12040372
5. Thorlund K, Dron L, Park J et al. A Real-Time Dashboard of Clinical Trials for COVID-19. Lancet Digit Health 2020. DOI: 10.1016/S2589-7500(20)30086-8
6. Hick JL, Biddinger PD. Novel Coronavirus and Old Lessons – Preparing the Health System for the Pandemic. N Engl J Med 2020; 382: e55. DOI: 10.1056/NEJMp2005118
7. Fauci AS, Lane HC, Redfield RR. Covid-19 – Navigating the Uncharted. N Engl J Med 2020; 382: 1268–9. DOI: 10.1056/NEJMe2002387
8. Cardona Maya WD, Du Plessis SS, Velilla PA. SARS-CoV-2 and the Testis: Similarity with Other Viruses and Routes of Infection. Reprod Biomed Online 2020. DOI: 10.1016/j.rbmo.2020.04.009. S1472648320301887
9. Wang Z, Xu X. ScRNA-Seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells. Cells 2020; 9: 920. DOI: 10.3390/cells9040920
10. Esteves SC, Lombardo F, Garrido N et al. SARS-CoV-2 Pandemic and Repercussions for Male Infertility Patients: A Proposal for the Individualized Provision of Andrological Services. Andrology 2020. DOI: 10.1111/andr.12809
11. Stanley KE, Thomas E, Leaver M, Wells D. Coronavirus Disease (COVID-19) and Fertility: Viral Host Entry Protein Expression in Male and Female Reproductive Tissues. Fertil Steril 2020. DOI: 10.1016/j.fertnstert.2020.05.001
12. Monteleone PA, Nakano M, Lazar V et al. A review of initial data on pregnancy during the COVID-19 outbreak: implications for assisted reproductive treatments. JBRA Assist Reprod 2020; 24: 219–25. DOI: 10.5935/1518-0557.20200030
13. Zhou G, Chen S, Chen Z. Advances in COVID-19: The Virus, the Pathogenesis, and Evidence-Based Control and Therapeutic Strategies. Front Med 2020; 14: 117–25. DOI: 10.1007/s11684-020-0773-x
14. Fan C, Li K, Ding Y et al. ACE2 expression in kidney and testis may cause kidney and testis damage after 2019-nCoV infection. MedRxiv 2020.
15. Xu J, Qi L, Chi X et al. Orchitis: a complication of severe acute respiratory syndrome (SARS)1. Biol Reprod 2006; 74: 410–6.
16. Zhao J, Zhou G, Sun Y. SARS coronavirus could cause multi-organ infection. Med J Chinese People’s Liberation Army 2003; 28: 697–8.
17. Pan F, Xiao X, Guo et al. No Evidence of SARS-CoV-2 in Semen of Males Recovering from COVID-19. Fertil Steril 2020. DOI: 10.1016/j.fertnstert.2020.04.024. S0015028220303848
18. Song C, Wang Y, Li W et al. Absence of 2019 Novel Coronavirus in Semen and Testes of COVID-19 Patients. Biol Reprod 2020. DOI: 10.1093/biolre/ioaa050
19. Chan JF, Yuan S, Kok KH et al. A Familial Cluster of Pneumonia Associated with the 2019 Novel Coronavirus Indicating Person-to-Person Transmission: A Study of a Family Cluster. Lancet 2020; 395: 514–23. DOI: 10.1016/S0140-6736(20)30154-9
20. Li D, Jin M, Bao P et al. Clinical Characteristics and Results of Semen Tests Among Men With Coronavirus Disease 2019. JAMA Netw Open 2020; 3: e208292. DOI: 10.1001/jamanetworkopen.2020.8292
21. Segars J, Katler Q, McQueen DB et al. for the ASRM Coronavirus/COVID-19 Task Force. Fertil Steril 2020.
________________________________________________
2. Mungroo MR, Khan NA, Siddiqui R. Novel Coronavirus: Current Understanding of Clinical Features, Diagnosis, Pathogenesis, and Treatment Options. Pathogens 2020; 9: E297. DOI: 10.3390/pathogens9040297
3. Zhu N, Zhang D, Wang W et al, China Novel Coronavirus Investigating and Research Team. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med 2020; 382: 727–33. DOI: 10.1056/NEJMoa2001017
4. Jin Y, Yang H, Ji W et al. Virology, Epidemiology, Pathogenesis, and Control of COVID-19. Viruses 2020; 12: E372. DOI: 10.3390/v12040372
5. Thorlund K, Dron L, Park J et al. A Real-Time Dashboard of Clinical Trials for COVID-19. Lancet Digit Health 2020. DOI: 10.1016/S2589-7500(20)30086-8
6. Hick JL, Biddinger PD. Novel Coronavirus and Old Lessons – Preparing the Health System for the Pandemic. N Engl J Med 2020; 382: e55. DOI: 10.1056/NEJMp2005118
7. Fauci AS, Lane HC, Redfield RR. Covid-19 – Navigating the Uncharted. N Engl J Med 2020; 382: 1268–9. DOI: 10.1056/NEJMe2002387
8. Cardona Maya WD, Du Plessis SS, Velilla PA. SARS-CoV-2 and the Testis: Similarity with Other Viruses and Routes of Infection. Reprod Biomed Online 2020. DOI: 10.1016/j.rbmo.2020.04.009. S1472648320301887
9. Wang Z, Xu X. ScRNA-Seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells. Cells 2020; 9: 920. DOI: 10.3390/cells9040920
10. Esteves SC, Lombardo F, Garrido N et al. SARS-CoV-2 Pandemic and Repercussions for Male Infertility Patients: A Proposal for the Individualized Provision of Andrological Services. Andrology 2020. DOI: 10.1111/andr.12809
11. Stanley KE, Thomas E, Leaver M, Wells D. Coronavirus Disease (COVID-19) and Fertility: Viral Host Entry Protein Expression in Male and Female Reproductive Tissues. Fertil Steril 2020. DOI: 10.1016/j.fertnstert.2020.05.001
12. Monteleone PA, Nakano M, Lazar V et al. A review of initial data on pregnancy during the COVID-19 outbreak: implications for assisted reproductive treatments. JBRA Assist Reprod 2020; 24: 219–25. DOI: 10.5935/1518-0557.20200030
13. Zhou G, Chen S, Chen Z. Advances in COVID-19: The Virus, the Pathogenesis, and Evidence-Based Control and Therapeutic Strategies. Front Med 2020; 14: 117–25. DOI: 10.1007/s11684-020-0773-x
14. Fan C, Li K, Ding Y et al. ACE2 expression in kidney and testis may cause kidney and testis damage after 2019-nCoV infection. MedRxiv 2020.
15. Xu J, Qi L, Chi X et al. Orchitis: a complication of severe acute respiratory syndrome (SARS)1. Biol Reprod 2006; 74: 410–6.
16. Zhao J, Zhou G, Sun Y. SARS coronavirus could cause multi-organ infection. Med J Chinese People’s Liberation Army 2003; 28: 697–8.
17. Pan F, Xiao X, Guo et al. No Evidence of SARS-CoV-2 in Semen of Males Recovering from COVID-19. Fertil Steril 2020. DOI: 10.1016/j.fertnstert.2020.04.024. S0015028220303848
18. Song C, Wang Y, Li W et al. Absence of 2019 Novel Coronavirus in Semen and Testes of COVID-19 Patients. Biol Reprod 2020. DOI: 10.1093/biolre/ioaa050
19. Chan JF, Yuan S, Kok KH et al. A Familial Cluster of Pneumonia Associated with the 2019 Novel Coronavirus Indicating Person-to-Person Transmission: A Study of a Family Cluster. Lancet 2020; 395: 514–23. DOI: 10.1016/S0140-6736(20)30154-9
20. Li D, Jin M, Bao P et al. Clinical Characteristics and Results of Semen Tests Among Men With Coronavirus Disease 2019. JAMA Netw Open 2020; 3: e208292. DOI: 10.1001/jamanetworkopen.2020.8292
21. Segars J, Katler Q, McQueen DB et al. for the ASRM Coronavirus/COVID-19 Task Force. Fertil Steril 2020.
Авторы
А.Ю. Попова*1,2, С.И. Гамидов1,2, Р.И. Овчинников1, Т.В. Шатылко1, Р.С. Гамидов2
1 ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова» Минздрава России, Москва, Россия;
2 ФГАОУ ВО «Первый Московский государственный медицинский универстит им. И.М. Сеченова» Минздрава России, Москва, Россия
*alina-dock@yandex.ru
1 Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia;
2 Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
*alina-dock@yandex.ru
1 ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова» Минздрава России, Москва, Россия;
2 ФГАОУ ВО «Первый Московский государственный медицинский универстит им. И.М. Сеченова» Минздрава России, Москва, Россия
*alina-dock@yandex.ru
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1 Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia;
2 Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
*alina-dock@yandex.ru
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