Гастроэзофагеальная рефлюксная болезнь в практике терапевта поликлиники: terra incognita

1. Hunt R, Armstrong D, Katelaris P et al. WGO Global Guidelines. GERD. World Gastroenterology Organisation, 2015.
2. Лазебник Л.Б., Машарова А.А., Бордин Д.С. и др. Многоцентровое исследование «Эпидемиология ГЭРБ в России» (МЭГРЕ): первые итоги. Экспериментальная и клиническая гастроэнтерология. 2009; 6: 4–12.
[Lazebnik L.B., Masharova A.A., Bordin D.S. et al. Mnogotsentrovoe issledovanie "Epidemiologiia GERB v Rossii" (MEGRE): pervye itogi. Eksperimental'naia i klinicheskaia gastroenterologiia. 2009; 6: 4–12 (in Russian).]
3. Vakil NB, van Zanten SV, Kahrilas P et al, Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 2006; 101: 1900–20; quiz 1943.
4. Ивашкин В.Т., Маев И.В., Трухманов А.С. и др. Клинические рекомендации Российской гастроэнтерологической ассоциации по диагностике и лечению гастроэзофагеальной рефлюксной болезни. Рос. журн. гастроэнтерологии, гепатологии, колопроктологии. 2017; 27 (4): 75–95.
[Ivashkin V.T., Maev I.V., Trukhmanov A.S. et al. Klinicheskie rekomendatsii Rossiiskoi gastroenterologicheskoi assotsiatsii po diagnostike i lecheniiu gastroezofageal'noi refliuksnoi bolezni. Ros. zhurn. gastroenterologii, gepatologii, koloproktologii. 2017; 27 (4): 75–95 (in Russian).]
5 Dent J, Becher A, Sung J et al. Systematic review: patterns of reflux-induced symptoms and esophageal endoscopic findings in large-scale surveys. Clin Gastroenterol Hepatol 2012; 10: 863–73.e3.
6. Маев И.В., Вьючнова Е.С., Щекина М.И. Гастроэзофагеальная рефлюксная болезнь – болезнь XXI века. Лечащий врач. 2004; 4.
[Maev I.V., V'iuchnova E.S., Shchekina M.I. Gastroezofageal'naia refliuksnaia bolezn' – bolezn' XXI veka. Lechashchii vrach. 2004; 4 (in Russian).]
7. Маев И.В., Самсонов А.А., Белый П.А., Лебедева Е.Г. ГЭРБ – лидер кислотозависимой патологии верхних отделов желудочно-кишечного тракта. Прил. Consilium Medicum. Гастроэнтерология. 2012; 1: 18–24.
[Maev I.V., Samsonov A.A., Belyi P.A., Lebedeva E.G. GERB – lider kislotozavisimoi patologii verkhnikh otdelov zheludochno-kishechnogo trakta. Pril. Consilium Medicum. Gastroenterology. 2012; 1: 18–24 (in Russian).]
8. Katz PO, Gerson LB, Vela MF. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol 2013; 108: 308–28; quiz 329.
9. Gyawall CP, Kahrilas PJ, Savarino E et al. Modern diagnosis of GERD: the Lyon Consensus. Gut, 2018.
10. Зайратьянц О.В., Кононов А.В. Пищевод Баррета. Клинические рекомендации Российского общества патологоанатомов. 2016. http://www.patolog.ru
[Zairat'iants O.V., Kononov A.V. Pishchevod Barreta. Klinicheskie rekomendatsii Rossiiskogo obshchestva patologoanatomov. 2016. http://www.patolog.ru (in Russian).]
11. Rubinstein JH, Scheiman JM, Whiteman D et al. Am J Gastroenterol 2011; 106 (2): 254–60.
12. Зайратьянц О.В., Маев И.В., Смольянникова В.А., Мовтаева П.Р. Патологическая анатомия пищевода Барретта. Арх. пат. 2011; 73 (3): 21–6.
[Zairat'iants O.V., Maev I.V., Smol'iannikova V.A., Movtaeva P.R. Patologicheskaia anatomiia pishchevoda Barretta. Arkh. pat. 2011; 73 (3): 21–6 (in Russian).]
13. Sharma P, Dent J, Armstrong D et al. The development and validation of an endoscopic grading system for Barrett's esophagus: the Prague C & M criteria. Gastroenterology 2006; 131 (5): 1392–9.
14. Dent J, Vakil N, Jones R et al. Accuracy of the diagnosis of GORD by questionnaire, physicians and a trial of proton pump inhibitor treatment: the Diamond Study. Gut 2010; 59: 714–21.
15. Бордин Д.С. Алгоритм ведения больных гастроэзофагеальной рефлюксной болезнью. Человек и лекарство. 2011; 2: 326–38.
[Bordin D.S. Algoritm vedeniia bol'nykh gastroezofageal'noi refliuksnoi bolezn'iu. Chelovek i lekarstvo. 2011; 2: 326–38 (in Russian).]
16. Bytzer P, Jones R, Vakil N et al. Limited ability of the proton-pump inhibitor test to identify patients with gastroesophageal reflux disease. Clin Gastroenterol Hepatol 2012; 10: 1360.
17. Исаков В.А. Терапия кислотозависимых заболеваний ингибиторами протонного насоса в вопросах и ответах. Consilium Medicum. 2006; 8 (7).
[Isakov V.A. Terapiia kislotozavisimykh zabolevanii ingibitorami protonnogo nasosa v voprosakh i otvetakh. Consilium Medicum. 2006; 8 (7) (in Russian).]
18. Tytgat GN et al. New algorithm for the treatment of gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2008; 27: 249–56.
19. Маев И.В., Самсонов А.А., Андреев Д.Н. Роль и место антацидов в современных алгоритмах терапии кислотозависимых заболеваний. Фарматека. Гастроэнтерология. Гепатология. 2013; 2 (255): 65–72.
[Maev I.V., Samsonov A.A., Andreev D.N. Rol' i mesto antatsidov v sovremennykh algoritmakh terapii kislotozavisimykh zabolevanii. Farmateka. Gastroenterologiia. Gepatologiia. 2013; 2 (255): 65–72 (in Russian).]
20. Эл. ресурс: www.grls.rosminzdrav.ru
[Available from: www.grls.rosminzdrav.ru (in Russian).]
21. Kapadia C. Cobalamin (Vitamin B12) deficiency: is it a problem for our aging population and is the problem compounded by drugs that inhibit gastric acid secretion? J Clin Gastroenterol 2000; 30: 4–6.
22. Sarzynski EI. Association between proton pump inhibitor use and anemia: a retrospective cohort study. Dig Dis Sci 2011; 56 (8): 2349–53; 5.
23. Epstein M et al. Proton-pump inhibitors and hypomagnesemic hypoparathyroidism. N Engl J Med 2006; 355 (17): 1834–6.
24. Lewis JR et al. Long-Term Proton Pump Inhibitor Therapy and Falls and Fractures in Elderly Women: A Prospective Cohort Study. J Bone Miner Res 2014.
25. Захарова Н.В. Подводные камни длительной кислотосупрессии ингибиторами протонной помпы. Лечащий врач. 2014; 8.
[Zakharova N.V. Podvodnye kamni dlitel'noi kislotosupressii ingibitorami protonnoi pompy. Lechashchii vrach. 2014; 8 (in Russian).]
26. Filion K et al. Proton pump inhibitors and the risk of hospitalisation for community-acquired pneumonia: replicated cohort studies with meta-analysis. Gut 2014; 63 (4): 552–8.
27. Miura KI et al. Proton pump inhibitor use is associated with spontaneous bacterial peritonitis in patients with liver cirrhosis. Intern Med 2014; 53 (10): 1037–42.
28. Карева Е.Н. Рабепразол через призму «метаболизм – эффективность». РМЖ. 2016; 17: 1172–6.
[Kareva E.N. Rabeprazol cherez prizmu "metabolizm – effektivnost''. RMZh. 2016; 17: 1172–6 (in Russian).]
29. Эл. ресурс: www.fda.gov/drug/safety/medwhatch/safetyinformation.
[Available from: www.fda.gov/drug/safety/medwhatch/safetyinformation (in Russian).]
30. Pauli-Magnus C et al. Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein. Naunyn Schniedebergs Arch Pharmacol 2001; 364: 551–7.
31. Успенский Ю.П., Барышникова Н.В., Пахомова И.Г. Клинические перспективы использования препаратов на основе альгиновой кислоты в лечении гастроэзофагеальной рефлюксной болезни. Рос. журн. гастроэнтерологии, гепатологии, колопроктологии. 2009; 19 (2): 79–84.
[Uspenskii Iu.P., Baryshnikova N.V., Pakhomova I.G. Klinicheskie perspektivy ispol'zovaniia preparatov na osnove al'ginovoi kisloty v lechenii gastroezofageal'noi refliuksnoi bolezni. Ros. zhurn. gastroenterologii, gepatologii, koloproktologii. 2009; 19 (2): 79–84 (in Russian).]
32. Успенский Ю.П., Пахомова И.Г., Ткаченко Е.И. Первый в России опыт использования альгинатсодержащего препарата в лечении ГЭРБ. Лечащий врач. 2007; 8: 78–80.
[Uspenskii Iu.P., Pakhomova I.G., Tkachenko E.I. Pervyi v Rossii opyt ispol'zovaniia al'ginatsoderzhashchego preparata v lechenii GERB. Lechashchii vrach. 2007; 8: 78–80 (in Russian).]
33. Бордин Д.С., Янова О.Б., Березина О.И., Трейман Е.В. Ингибиторы протонной помпы и альгинаты в первые дни лечения гастроэзофагеальной рефлюксной болезни: преимущества совместного приема. Врач. 2014; 10: 22–6.
[Bordin D.S., Ianova O.B., Berezina O.I., Treiman E.V. Ingibitory protonnoi pompy i al'ginaty v pervye dni lecheniia gastroezofageal'noi refliuksnoi bolezni: preimushchestva sovmestnogo priema. Vrach. 2014; 10: 22–6 (in Russian).]
34. Coping with common GI symptoms in the community: a global perspective on heartburn, constipation, bloating, and abdominal pain/discomfort. World Gastroenterology Organisation; 2013. http://www.worldgastroenterology.org/
35. Заметки с конференции «Пищевод 2014. Воспаление, повреждение, рак и их профилактика» Москва, 16 сентября 2014 г. www.gastroscan.ru
[Zametki s konferentsii "Pishchevod 2014. Vospalenie, povrezhdenie, rak i ikh profilaktika" Moskva, 16 sentiabria 2014 g. www.gastroscan.ru (in Russian).]

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1. Hunt R, Armstrong D, Katelaris P et al. WGO Global Guidelines. GERD. World Gastroenterology Organisation, 2015.
2. Lazebnik L.B., Masharova A.A., Bordin D.S. et al. Mnogotsentrovoe issledovanie "Epidemiologiia GERB v Rossii" (MEGRE): pervye itogi. Eksperimental'naia i klinicheskaia gastroenterologiia. 2009; 6: 4–12 (in Russian).
3. Vakil NB, van Zanten SV, Kahrilas P et al, Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 2006; 101: 1900–20; quiz 1943.
4. Ivashkin V.T., Maev I.V., Trukhmanov A.S. et al. Klinicheskie rekomendatsii Rossiiskoi gastroenterologicheskoi assotsiatsii po diagnostike i lecheniiu gastroezofageal'noi refliuksnoi bolezni. Ros. zhurn. gastroenterologii, gepatologii, koloproktologii. 2017; 27 (4): 75–95 (in Russian).
5 Dent J, Becher A, Sung J et al. Systematic review: patterns of reflux-induced symptoms and esophageal endoscopic findings in large-scale surveys. Clin Gastroenterol Hepatol 2012; 10: 863–73.e3.
6. Maev I.V., V'iuchnova E.S., Shchekina M.I. Gastroezofageal'naia refliuksnaia bolezn' – bolezn' XXI veka. Lechashchii vrach. 2004; 4 (in Russian).
7. Maev I.V., Samsonov A.A., Belyi P.A., Lebedeva E.G. GERB – lider kislotozavisimoi patologii verkhnikh otdelov zheludochno-kishechnogo trakta. Pril. Consilium Medicum. Gastroenterology. 2012; 1: 18–24 (in Russian).
8. Katz PO, Gerson LB, Vela MF. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol 2013; 108: 308–28; quiz 329.
9. Gyawall CP, Kahrilas PJ, Savarino E et al. Modern diagnosis of GERD: the Lyon Consensus. Gut, 2018.
10. Zairat'iants O.V., Kononov A.V. Pishchevod Barreta. Klinicheskie rekomendatsii Rossiiskogo obshchestva patologoanatomov. 2016. http://www.patolog.ru (in Russian).
11. Rubinstein JH, Scheiman JM, Whiteman D et al. Am J Gastroenterol 2011; 106 (2): 254–60.
12. Zairat'iants O.V., Maev I.V., Smol'iannikova V.A., Movtaeva P.R. Patologicheskaia anatomiia pishchevoda Barretta. Arkh. pat. 2011; 73 (3): 21–6 (in Russian).
13. Sharma P, Dent J, Armstrong D et al. The development and validation of an endoscopic grading system for Barrett's esophagus: the Prague C & M criteria. Gastroenterology 2006; 131 (5): 1392–9.
14. Dent J, Vakil N, Jones R et al. Accuracy of the diagnosis of GORD by questionnaire, physicians and a trial of proton pump inhibitor treatment: the Diamond Study. Gut 2010; 59: 714–21.
15. Bordin D.S. Algoritm vedeniia bol'nykh gastroezofageal'noi refliuksnoi bolezn'iu. Chelovek i lekarstvo. 2011; 2: 326–38 (in Russian).
16. Bytzer P, Jones R, Vakil N et al. Limited ability of the proton-pump inhibitor test to identify patients with gastroesophageal reflux disease. Clin Gastroenterol Hepatol 2012; 10: 1360.
17. Isakov V.A. Terapiia kislotozavisimykh zabolevanii ingibitorami protonnogo nasosa v voprosakh i otvetakh. Consilium Medicum. 2006; 8 (7) (in Russian).
18. Tytgat GN et al. New algorithm for the treatment of gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2008; 27: 249–56.
19. Маев И.В., Самсонов А.А., Андреев Д.Н. Роль и место антацидов в современных алгоритмах терапии кислотозависимых заболеваний. Фарматека. Гастроэнтерология. Гепатология. 2013; 2 (255): 65–72.
[Maev I.V., Samsonov A.A., Andreev D.N. Rol' i mesto antatsidov v sovremennykh algoritmakh terapii kislotozavisimykh zabolevanii. Farmateka. Gastroenterologiia. Gepatologiia. 2013; 2 (255): 65–72 (in Russian).]
20. Available from: www.grls.rosminzdrav.ru (in Russian).
21. Kapadia C. Cobalamin (Vitamin B12) deficiency: is it a problem for our aging population and is the problem compounded by drugs that inhibit gastric acid secretion? J Clin Gastroenterol 2000; 30: 4–6.
22. Sarzynski EI. Association between proton pump inhibitor use and anemia: a retrospective cohort study. Dig Dis Sci 2011; 56 (8): 2349–53; 5.
23. Epstein M et al. Proton-pump inhibitors and hypomagnesemic hypoparathyroidism. N Engl J Med 2006; 355 (17): 1834–6.
24. Lewis JR et al. Long-Term Proton Pump Inhibitor Therapy and Falls and Fractures in Elderly Women: A Prospective Cohort Study. J Bone Miner Res 2014.
25. Zakharova N.V. Podvodnye kamni dlitel'noi kislotosupressii ingibitorami protonnoi pompy. Lechashchii vrach. 2014; 8 (in Russian).
26. Filion K et al. Proton pump inhibitors and the risk of hospitalisation for community-acquired pneumonia: replicated cohort studies with meta-analysis. Gut 2014; 63 (4): 552–8.
27. Miura KI et al. Proton pump inhibitor use is associated with spontaneous bacterial peritonitis in patients with liver cirrhosis. Intern Med 2014; 53 (10): 1037–42.
28. Kareva E.N. Rabeprazol cherez prizmu "metabolizm – effektivnost''. RMZh. 2016; 17: 1172–6 (in Russian).
29. Available from: www.fda.gov/drug/safety/medwhatch/safetyinformation (in Russian).
30. Pauli-Magnus C et al. Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein. Naunyn Schniedebergs Arch Pharmacol 2001; 364: 551–7.
31. Uspenskii Iu.P., Baryshnikova N.V., Pakhomova I.G. Klinicheskie perspektivy ispol'zovaniia preparatov na osnove al'ginovoi kisloty v lechenii gastroezofageal'noi refliuksnoi bolezni. Ros. zhurn. gastroenterologii, gepatologii, koloproktologii. 2009; 19 (2): 79–84 (in Russian).
32. Uspenskii Iu.P., Pakhomova I.G., Tkachenko E.I. Pervyi v Rossii opyt ispol'zovaniia al'ginatsoderzhashchego preparata v lechenii GERB. Lechashchii vrach. 2007; 8: 78–80 (in Russian).
33. Bordin D.S., Ianova O.B., Berezina O.I., Treiman E.V. Ingibitory protonnoi pompy i al'ginaty v pervye dni lecheniia gastroezofageal'noi refliuksnoi bolezni: preimushchestva sovmestnogo priema. Vrach. 2014; 10: 22–6 (in Russian).
34. Coping with common GI symptoms in the community: a global perspective on heartburn, constipation, bloating, and abdominal pain/discomfort. World Gastroenterology Organisation; 2013. http://www.worldgastroenterology.org/
35. Zametki s konferentsii "Pishchevod 2014. Vospalenie, povrezhdenie, rak i ikh profilaktika" Moskva, 16 sentiabria 2014 g. www.gastroscan.ru (in Russian).

Е.И. Вовк, Ю.В. Седякина, М.М. Шамуилова, А.В. Носова, С.С. Курджиева, А.Л. Верткин

ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России, Москва, Россия
*knorring@mail.ru

________________________________________________

Elena I. Vovk, Iuliia V. Sediakina, Marina M. Shamuilova, Anna V. Nosova, Svetlana S. Kurdgieva, Arkadii L. Vertkin

Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
*knorring@mail.ru