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Внутривенная тромболитическая терапия инфаркта мозга вследствие окклюзии артерии Першерона. Клиническое наблюдение
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Chugunova SA, Popov MM, Makievskaya AE, Yakovleva NV, Tarabukina VV. Intravenous thrombolytic therapy for cerebral infarction due to the Persheron artery occlusion. Case report. Consilium Medicum. 2021;23(11):800–804.
DOI: 10.26442/20751753.2021.11.201092
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Ключевые слова: инфаркт мозга, артерия Першерона, магнитно-резонансная томография, внутривенная тромболитическая терапия
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Occlusion of the artery of Percheron is the cause of bilateral thalamic infarctions, sometimes involving structures of the midbrain. A clinical case of intravenous thrombolytic therapy for ischemic stroke due to the occlusion of the Percheron artery in a 72-year-old female patient who developed depression of consciousness, oculomotor disorders, dysarthria, ataxia, pyramidal disorders, and cognitive disorders is presented. Magnetic resonance imaging, which detected bilateral thalamus paramedian infarction in the acute stage, made it possible to diagnose the occlusion of the Percheron artery. Intravenous thrombolysis led to a rapid regression of symptoms; at the end of the acute period of the disease, the patient was discharged from the hospital with a slight neurological deficit and with a good functional outcome. After a one year the dynamic observation revealed persistent mild cognitive disorders; magnetic resonance imaging showed small symmetric cystic-gliosis changes in the medial parts of the thalamus on both sides. Timely diagnosis and intravenous thrombolytic therapy contribute to a good outcome of cerebral infarction due to the Percheron's artery occlusion.
Keywords: cerebral infarction, Percheron's artery, magnetic resonance imaging, intravenous thrombolytic therapy
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2. Caruso P, Manganotti P, Moretti R. Complex neurological symptoms in bilateral thalamic stroke due to Percheron artery occlusion. Vasc Health Risk Manag. 2016;13:11-4.
3. Payenok AV, Shevaha VM, Kulyk AR, et al. Stroke in the artery of percheron territory: the two edges of one diagnosis. Wiad Lek. 2019;72(9 cz 2):1851-3.
4. Fursova LA, Naumenko DV. Talamicheskie infarkty v bassejne arterii Percheron: klinika i diagnostika. Mezhdunarodny jnevrologicheski jzhurnal. 2013;55(1):25-32 (in Russian)
5. Garcia-Grimshaw MA, Peschard-Franco M, Gutierrez-Manjarrez FA. Bilateral Thalamic Ischemic Stroke Secondary to Occlusion of the Artery of Percheron. Cureus. 2018;10(5):e2676.
6. Zappella N, Merceron S, Nifle C, et al. Artery of Percheron Infarction as an Unusual Cause of Coma: Three Cases and Literature Review. Neurocrit Care. 2014;20(3):494-501.
7. Kichloo A, Jamal SM, Zain El-A, et al. Artery of Percheron Infarction: A Short Review. J Investig Med High Impact Case Rep. 2019;7:2324709619867355.
8. Shamalov NA, Hasanova DR, Stahovskaja LV, et al. Reperfuzionnaia terapiia ishemicheskogo insul'ta. Klinicheskii protokol. Moscow, 2019 (in Russian)
9. Xu Z, Sun L, Duan Y, et al. Assessment of Percheron Infarction in Images and Clinical Findings. J Neurol Sci. 2017;383:87-92.
10. Titov AV, Mozgovaja OE. Talamicheskij ishemicheskij insult vsledstvie okkljuzii arterii Persherona. Vestnik rentgenologii i radiologii. 2020;101(2):121-5 (in Russian)
11. Lazzaro NA, Wright B, Castillo M, et al. Artery of Percheron infarction: imaging patterns and clinical spectrum. AJNR Am J Neuroradiol. 2010;31(7):1283-9.
12. Ben Saida I, Ben Saad H, Zghidi M, et al. Artery of Percheron Stroke as an Unusual Cause of Hypersomnia: A Case Series and a Short Literature Review. Am J Mens Health. 2020;14(4):1557988320938946.
13. Grigoreva VN, Semenova TN, Grigoreva KA. "Talamicheskaja demencija" pri bilateralnom insulte zritelnyh bugrov: dinamika kognitivnyh rasstrojstv. Nevrologicheskij zhurnal. 2017;22(2):86-96 (in Russian).
14. Wong ML, Edlow JA. Artery of Percheron Stroke. J Emerg Med. 2018;55(1):114-7.
15. Acciarresi M, Alberti A. Impaired Consciousness. Front Neurol Neurosci. 2012;30:34-7.
16. Pitts-Tucker T, Small J. Artery of Percheron: an unusual stroke presentation. BMJ Case Rep. 2018;2018:bcr2017222185.
17. Sandvig A, Lundberg S, Neuwirth J. Artery of Percheron infarction: a case report. J Med Case Rep. 2017;11(1):221.
18. Stamm BJ, Lineback CM, Skolarus LE, et al. Artery of Percheron Infarct: 12 Cases and Their Complex Clinical Courses. Neurohospitalist. 2018;8(3):141-5.
1 ФГАОУ ВО «Северо-Восточный федеральный университет им. М.К. Аммосова», Якутск, Россия;
2 ГБУ Республики Саха (Якутия) «Республиканская больница №2 – Центр экстренной медицинской помощи», Якутск, Россия
*sa.chugunova@mail.ru
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Sargylana A. Chugunova*1, Mikhail M. Popov2, Anastasia E. Makievskaya2, Natalia V. Yakovleva2, Varvara V. Tarabukina2
1 Ammosov North-Eastern Federal University, Yakutsk, Russia;
2 Republican Hospital №2 – Emergency Medical Center, Yakutsk, Russia
*sa.chugunova@mail.ru