Клинико-фармакологические особенности различных форм оригинального ибупрофена при лечении заболеваний, проявляющихся болью

1. Здравоохранение в России. 2017. Статистический сборник. М.: Росстат; 2017 [Zdravookhranenie v Rossii. 2017. Statisticheskii sbornik. Moscow: Rosstat  (in Russian)].
2. Cooper R, Booker C, Spanswick C. What is pain management, and what its relevance to the rheumatologist? Rheumatology (Oxford). 2003; 42: 1133–7.
3. Ward M. Clinical measures in rheumatoid arthritis: which are useful in assessing patients? J Rheumatol. 1994; 21: 17–27.
4. Fitzcharles MA, Almahrezi A, Shir Y. Pain: understanding and challengers for the Rheumatologist. Arthritis Rheum. 2005; 52: 3685–92.
5. Brune K, Hinz B. The discovery and development of anti-inflammatory drugs. Arthritis Rheum. 2004; 50: 2391–9
6. Emery P. Considerations for nonsteroidal anti-inflammatory drug therapy: benefits. Scand J Rheumatol. 1996; 25 (Suppl. 105): 5–12.
7. Lain L. Approaches to nonsteroidal antiinflammatory drug use in high-risk patient. Gastroenterology. 2001;120: 594–606.
8. Каратеев А.Е., Насонов Е.Л., Ивашкин В.Т., и др. Рациональное использование нестероидных противовоспалительных препаратов. Научно-практическая ревматология. 2018; 56 (Прил. 1): 1–29 [Karateev AE, Nasonov EL, Ivashkin VT, et al. Ratsional'noe ispol'zovanie nesteroidnykh protivovospalitel'nykh preparatov. Nauchno-prakticheskaia revmatologiia. 2018; 56 (Pril. 1): 1–29 (in Russian)].
9. Cohen P. Non-steroidal anti-inflammatory drugs and serious gastrointestinal adverse reactions. Br Med J. 1986; 293 (6538): 51. DOI: 10.1136/bmj.293.6538.51-a
10. Codispoti J, Prior M, Fu M, et al. Efficacy of nonprescription doses of ibuprofen for treating migraine headache: a randomized controlled trial. Headache. 2001; 41 (7): 665–79. 
11. Suthisisang C, Poolsup N, Kittikulsuth W, et al. Efficacy of low-dose ibuprofen in acute migraine treatment: systematic review and meta-analysis. Ann Pharmacother. 2007; 41 (11): 1782–91. 
12. Rabbie R, Derry S, Moore RA, McQuay HJ. Ibuprofen with or without an antiemetic for acute migraine headaches in adults. Cochrane Database Syst Rev. 2010; 10: CD008039. DOI: 10.1002/14651858.CD008039.pub2
13. Marmura MJ, Silberstein SD, Schwedt TJ. The acute treatment of migraine in adults: the American headache society evidence assessment of migraine pharmacotherapies. Headache. 2015; 55 (1): 3–20. DOI: 10.1111/head.12499
14. Ekman E, Fiechtner J, Levy S, Fort J. Efficacy of celecoxib versus ibuprofen in the treatment of acute pain: a multicenter, double-blind, randomized controlled trial in acute ankle sprain. Am J Orthop. 2002; 31 (8): 445–51.
15. Bradley R, Ellis P, Thomas P, et al. A randomized clinical trial comparing the efficacy of ibuprofen and paracetamol in the control of orthodontic pain. Am J Orthod Dentofacial Orthop. 2007; 132 (4): 511–7.
16. Dreiser R, Marty M, Ionescu E, et al. Relief of acute low back pain with diclofenac-K 12.5 mg tablets: a flexible dose, ibuprofen 200 mg and placebo-controlled clinical trial. Int J Clin Pharmacol Ther. 2003; 41 (9): 375–85. 
17. Milsom I, Minic M, Dawood M, et al. Comparison of the efficacy and safety of nonprescription doses of naproxen and naproxen sodium with ibuprofen, acetaminophen, and placebo in the treatment of primary dysmenorrhea: a pooled analysis of five studies. Clin Ther. 2002; 24 (9): 1384–400.
18. Moore R, Derry S, McQuay H, Wiffen P. Single dose oral analgesics for acute postoperative pain in adults. Cochrane Database Syst Rev. 2011; 9: CD008659.
19. Adatia A, Rainsford KD, Kean WF. Osteoarthritis of the knee and hip. Part II: therapy with ibuprofen and a review of clinical trials. J Pharm Pharmacol. 2012; 64 (5): 626–36. DOI: 10.1111/j.2042-7158.2012.01456.x
20. Boureau F, Schneid H, Zeghari N, et al. The IPSO study: ibuprofen, paracetamol study in osteoarthritis. A randomised comparative clinical study comparing the efficacy and safety of ibuprofen and paracetamol analgesic treatment of osteoarthritis of the knee or hip. Ann Rheum Dis. 2004; 63 (9): 1028–34.
21. Katz JN, Smith SR, Collins JE, et al. Cost-effectiveness of nonsteroidal anti-inflammatory drugs and opioids in the treatment of knee osteoarthritis in older patients with multiple comorbidities. ­Osteoarthrit Cartil. 2016; 24 (3): 409–18. DOI: 10.1016/j.joca.2015.10.006
22. Silverstein F, Faich G, Goldstein J, et al. Gastrointestinal toxicity with celecoxib versus nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial. Celecoxid long-term arthritis safety study. JAMA. 2000; 284: 1247–55.
23. Farkouh M, Kirshner H, Harrington R. Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), cardiovascular outcomes: randomized controlled trial. Lancet. 2004; 364: 675–84.
24. Sörgel F, Fuhr U, Minic M, et al. Pharmacokinetics of ibuprofen sodium dihydrate and gastrointestinal tolerability of short-term treatment with a novel, rapidly absorbed formulation. Int J Clin Pharmacol Ther. 2005; 43 (3): 140–9. DOI: 10.5414/cpp43140
25. Bjarnason I, Sancak O, Crossleyet A, et al. Differing disintegration and dissolution rates, pharmacokinetic profiles and gastrointestinal tolerability of over the counter ibuprofen formulations. J Pharm Pharmacol. 2018; 70 (2): 223–33. DOI: 10.1111/jphp.12827
26. Derry C, Derry S, Moore RA, McQuay HJ. Single dose oral ibuprofen for acute postoperative pain in adults. Cochrane Database Syst Rev. 2009: CD001548.
27. Laska EM, Sunshine A, Marrero I, et al. The correlation between blood levels of ibuprofen and clinical analgesic response. Clin Pharmacol Ther. 1986; 40: 1–7.
28. Mehlisch DR, Sykes J. Ibuprofen blood plasma levels and onset of analgesia. Int J Clin Pract. 2013; 67: 3–8. 
29. Moore AR. Faster, higher, stronger? Evidence for formulation and efficacy for ibuprofen in acute pain. Pain. 2014; 155 (1): 14–21. DOI: 10.1016/j.pain.2013.08.013
30. Ong CK, Seymour RA, Lirk P, Merry AF. Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain. Anesth Analg. 2010; 110 (4): 1170–9. DOI: 10.1213/ANE.0b013e3181cf9281
31. Раменская Г.В., Шохин И.Е., Кулинич Ю.И. Классификации лекарственных веществ по их биофармацевтическим свойствам – БКС и BDDCS. Вестник ВГУ. Химия. Биология. Фармация. 2012; 1: 212–5 [Ramenskaia GV, Shokhin IE, Kulinich IuI. Klassifikatsii lekarstvennykh veshchestv po ikh biofarmatsevticheskim svoistvam – BKS i BDDCS. Vestnik VGU. Khimiia. Biologiia. Farmatsiia. 2012; 1: 212–5 (in Russian)].
32. Atkinson HC, Stanescu I, Frampton C, et al. Pharmacokinetics and Bioavailability of a Fixed-Dose Combination of Ibuprofen and Paracetamol after Intravenous and Oral Administration. Clin Drug Investig. 2015; 35 (10): 625–32. DOI: 10.1007/s40261-015-0320-8
33. Tanner T, Aspley S, Munn A, Thomas T. The pharmacokinetic profile of a novel fixed-dose combination tablet of ibuprofen and paracetamol. BMC Clin Pharmacol. 2010; 10: 10. DOI: 10.1186/1472-6904-10-10
34. Каратеев А.Е. Комбинация ибупрофена и парацетамола: первая ступень эффективного контроля скелетно-мышечной боли. РМЖ. 2017; 2: 1562–6 [Karateev AE. Kombinatsiia ibuprofena i paratsetamola: pervaia stupen' effektivnogo kontrolia skeletno-myshechnoi boli. RMZh. 2017; 2: 1562–6 (in Russian)].
35. Derry CJ, Derry S, Moore RA. Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain. Cochrane Database Syst Rev. 2013; 6: CD010210. DOI: 10.1002/14651858.CD010210.pub2
36. Moore RA, Wiffen PJ, Derry S, et al. Non-prescription (OTC) oral analgesics for acute pain – an overview of Cochrane reviews. Cochrane Database Syst Rev. 2015; 11: CD010794. DOI: 10.1002/14651858.CD010794.pub2
37. Bailey E, Worthington H, Coulthard P. Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth, a Cochrane systematic review. Br Dent J. 2014; 216 (8): 451–5. DOI: 10.1038/sj.bdj.2014.330
38. Alexander L, Hall E, Eriksson L, Rohlin M. The combination of non-selective NSAID 400 mg and paracetamol 1000 mg is more effective than each drug alone for treatment of acute pain. A systematic review. Swed Dent J. 2014; 38 (1): 1–14. 
39. Mehlisch DR, Asple S, Daniels SE, et al. A Single-Tablet Fixed-Dose Combination of Racemic Ibuprofen/Paracetamol in the Management of Moderate to Severe Postoperative Dental Pain in Adult and Adolescent Patients: A Multicenter, Two-Stage, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Factorial Study. Clin Ther. 2010; 32: 1033–49.
40. Moore PA, Hersh EV. Combining ibuprofen and acetaminophen for acute pain management after third-molar extractions: translating clinical research to dental practice. J Am Dent Assoc. 2013; 144 (8): 898–908. DOI: 10.14219/jada.archive.2013.0207
41. Daniels SE, Goulder MA, Aspley S, Reader S. A Randomised, Five-Parallel-Group, Placebo-Controlled Trial Comparing the Efficacy and Tolerability of Analgesic Combinations Including a Novel Single-Tablet Combination of Ibuprofen/Paracetamol for Postoperative Dental Pain. Pain. 2011; 152 (3): 632–42.
42. Doherty M, Hawkey C, Goulder M, et al. A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain. Ann Rheum Dis. 2011; 70 (9): 1534–41. DOI: 10.1136/ard.2011.154047 
43. Ostojic P, Radunovic G, Lazovic M, Tomanovic-Vujadinovic S. Ibuprofen plus paracetamol versus ibuprofen in acute low back pain: a randomized open label multicenter clinical study. Acta Reumatol Port. 2017; 42 (1): 18–25.
44. Rampal P, Moore N, Van Ganse E, et al. Gastrointestinal tolerability of ibuprofen compared with paracetamol and aspirin at over-the-counter doses. J Int Med Res. 2002; 30 (3): 301–8.
45. Strom B, Schinnar R, Bilker W, et al. Gastrointestinal tract bleeding associated with naproxen sodium vs ibuprofen. Arch Intern Med. 1997; 157 (22): 2626–31.
46. Castellsague J, Riera-Guardia N, Calingaert B, et al. Individual NSAIDs and upper gastrointestinal complications: a systematic review and meta-analysis of observational studies (the SOS project). Drug Saf. 2012; 35 (12): 1127–46. DOI: 10.2165/11633470-000000000-00000
47. Varas-Lorenzo C, Riera-Guardia N, Calingaert B, et al. Myocardial infarction and individual nonsteroidal anti-inflammatory drugs meta-analysis of observational studies. Pharmacoepidemiol Drug Saf. 2013; 22: 559–70. DOI: 10.1002/pds
48. Белоусов Ю.Б., Гуревич К.Г. Влияние НПВП и парацетамола на сердечно-сосудистую систему. Клин. фармакологическая терапия. 2002; 5: 5–7 [Belousov IuB, Gurevich KG. Vliianie NPVP i paratsetamola na serdechno-sosudistuiu sistemu. Klin. farmakologicheskaia terapiia. 2002; 5: 5–7 (in Russian)].
49. Каратеев А.Е., Яхно Н.Н., Лазебник Л.Б., и др. Применение нестероидных противовоспалительных препаратов. Клинические рекомендации. М.: ИМА-ПРЕСС, 2009 [Karateev AE, Yakhno NN, Lazebnik LB, et al. The use of non-steroidal anti-inflammatory drugs. Clinical guidelines. Moscow: IMA-PRESS (in Russian)].
50. McGettigan P, Henry D. Cardiovascular risk and inhibition of cyclooxygenase. JAMA. 2006; 296: 1633–44.

________________________________________________

1. Zdravookhranenie v Rossii. 2017. Statisticheskii sbornik. Moscow: Rosstat  (in Russian).
2. Cooper R, Booker C, Spanswick C. What is pain management, and what its relevance to the rheumatologist? Rheumatology (Oxford). 2003; 42: 1133–7.
3. Ward M. Clinical measures in rheumatoid arthritis: which are useful in assessing patients? J Rheumatol. 1994; 21: 17–27.
4. Fitzcharles MA, Almahrezi A, Shir Y. Pain: understanding and challengers for the Rheumatologist. Arthritis Rheum. 2005; 52: 3685–92.
5. Brune K, Hinz B. The discovery and development of anti-inflammatory drugs. Arthritis Rheum. 2004; 50: 2391–9
6. Emery P. Considerations for nonsteroidal anti-inflammatory drug therapy: benefits. Scand J Rheumatol. 1996; 25 (Suppl. 105): 5–12.
7. Lain L. Approaches to nonsteroidal antiinflammatory drug use in high-risk patient. Gastroenterology. 2001;120: 594–606.
8. Karateev AE, Nasonov EL, Ivashkin VT, et al. Ratsional'noe ispol'zovanie nesteroidnykh protivovospalitel'nykh preparatov. Nauchno-prakticheskaia revmatologiia. 2018; 56 (Pril. 1): 1–29 (in Russian).
9. Cohen P. Non-steroidal anti-inflammatory drugs and serious gastrointestinal adverse reactions. Br Med J. 1986; 293 (6538): 51. DOI: 10.1136/bmj.293.6538.51-a
10. Codispoti J, Prior M, Fu M, et al. Efficacy of nonprescription doses of ibuprofen for treating migraine headache: a randomized controlled trial. Headache. 2001; 41 (7): 665–79. 
11. Suthisisang C, Poolsup N, Kittikulsuth W, et al. Efficacy of low-dose ibuprofen in acute migraine treatment: systematic review and meta-analysis. Ann Pharmacother. 2007; 41 (11): 1782–91. 
12. Rabbie R, Derry S, Moore RA, McQuay HJ. Ibuprofen with or without an antiemetic for acute migraine headaches in adults. Cochrane Database Syst Rev. 2010; 10: CD008039. DOI: 10.1002/14651858.CD008039.pub2
13. Marmura MJ, Silberstein SD, Schwedt TJ. The acute treatment of migraine in adults: the American headache society evidence assessment of migraine pharmacotherapies. Headache. 2015; 55 (1): 3–20. DOI: 10.1111/head.12499
14. Ekman E, Fiechtner J, Levy S, Fort J. Efficacy of celecoxib versus ibuprofen in the treatment of acute pain: a multicenter, double-blind, randomized controlled trial in acute ankle sprain. Am J Orthop. 2002; 31 (8): 445–51.
15. Bradley R, Ellis P, Thomas P, et al. A randomized clinical trial comparing the efficacy of ibuprofen and paracetamol in the control of orthodontic pain. Am J Orthod Dentofacial Orthop. 2007; 132 (4): 511–7.
16. Dreiser R, Marty M, Ionescu E, et al. Relief of acute low back pain with diclofenac-K 12.5 mg tablets: a flexible dose, ibuprofen 200 mg and placebo-controlled clinical trial. Int J Clin Pharmacol Ther. 2003; 41 (9): 375–85. 
17. Milsom I, Minic M, Dawood M, et al. Comparison of the efficacy and safety of nonprescription doses of naproxen and naproxen sodium with ibuprofen, acetaminophen, and placebo in the treatment of primary dysmenorrhea: a pooled analysis of five studies. Clin Ther. 2002; 24 (9): 1384–400.
18. Moore R, Derry S, McQuay H, Wiffen P. Single dose oral analgesics for acute postoperative pain in adults. Cochrane Database Syst Rev. 2011; 9: CD008659.
19. Adatia A, Rainsford KD, Kean WF. Osteoarthritis of the knee and hip. Part II: therapy with ibuprofen and a review of clinical trials. J Pharm Pharmacol. 2012; 64 (5): 626–36. DOI: 10.1111/j.2042-7158.2012.01456.x
20. Boureau F, Schneid H, Zeghari N, et al. The IPSO study: ibuprofen, paracetamol study in osteoarthritis. A randomised comparative clinical study comparing the efficacy and safety of ibuprofen and paracetamol analgesic treatment of osteoarthritis of the knee or hip. Ann Rheum Dis. 2004; 63 (9): 1028–34.
21. Katz JN, Smith SR, Collins JE, et al. Cost-effectiveness of nonsteroidal anti-inflammatory drugs and opioids in the treatment of knee osteoarthritis in older patients with multiple comorbidities. ­Osteoarthrit Cartil. 2016; 24 (3): 409–18. DOI: 10.1016/j.joca.2015.10.006
22. Silverstein F, Faich G, Goldstein J, et al. Gastrointestinal toxicity with celecoxib versus nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial. Celecoxid long-term arthritis safety study. JAMA. 2000; 284: 1247–55.
23. Farkouh M, Kirshner H, Harrington R. Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), cardiovascular outcomes: randomized controlled trial. Lancet. 2004; 364: 675–84.
24. Sörgel F, Fuhr U, Minic M, et al. Pharmacokinetics of ibuprofen sodium dihydrate and gastrointestinal tolerability of short-term treatment with a novel, rapidly absorbed formulation. Int J Clin Pharmacol Ther. 2005; 43 (3): 140–9. DOI: 10.5414/cpp43140
25. Bjarnason I, Sancak O, Crossleyet A, et al. Differing disintegration and dissolution rates, pharmacokinetic profiles and gastrointestinal tolerability of over the counter ibuprofen formulations. J Pharm Pharmacol. 2018; 70 (2): 223–33. DOI: 10.1111/jphp.12827
26. Derry C, Derry S, Moore RA, McQuay HJ. Single dose oral ibuprofen for acute postoperative pain in adults. Cochrane Database Syst Rev. 2009: CD001548.
27. Laska EM, Sunshine A, Marrero I, et al. The correlation between blood levels of ibuprofen and clinical analgesic response. Clin Pharmacol Ther. 1986; 40: 1–7.
28. Mehlisch DR, Sykes J. Ibuprofen blood plasma levels and onset of analgesia. Int J Clin Pract. 2013; 67: 3–8. 
29. Moore AR. Faster, higher, stronger? Evidence for formulation and efficacy for ibuprofen in acute pain. Pain. 2014; 155 (1): 14–21. DOI: 10.1016/j.pain.2013.08.013
30. Ong CK, Seymour RA, Lirk P, Merry AF. Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain. Anesth Analg. 2010; 110 (4): 1170–9. DOI: 10.1213/ANE.0b013e3181cf9281
31. Ramenskaia GV, Shokhin IE, Kulinich IuI. Klassifikatsii lekarstvennykh veshchestv po ikh biofarmatsevticheskim svoistvam – BKS i BDDCS. Vestnik VGU. Khimiia. Biologiia. Farmatsiia. 2012; 1: 212–5 (in Russian).
32. Atkinson HC, Stanescu I, Frampton C, et al. Pharmacokinetics and Bioavailability of a Fixed-Dose Combination of Ibuprofen and Paracetamol after Intravenous and Oral Administration. Clin Drug Investig. 2015; 35 (10): 625–32. DOI: 10.1007/s40261-015-0320-8
33. Tanner T, Aspley S, Munn A, Thomas T. The pharmacokinetic profile of a novel fixed-dose combination tablet of ibuprofen and paracetamol. BMC Clin Pharmacol. 2010; 10: 10. DOI: 10.1186/1472-6904-10-10
34. Karateev AE. Kombinatsiia ibuprofena i paratsetamola: pervaia stupen' effektivnogo kontrolia skeletno-myshechnoi boli. RMZh. 2017; 2: 1562–6 (in Russian).
35. Derry CJ, Derry S, Moore RA. Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain. Cochrane Database Syst Rev. 2013; 6: CD010210. DOI: 10.1002/14651858.CD010210.pub2
36. Moore RA, Wiffen PJ, Derry S, et al. Non-prescription (OTC) oral analgesics for acute pain – an overview of Cochrane reviews. Cochrane Database Syst Rev. 2015; 11: CD010794. DOI: 10.1002/14651858.CD010794.pub2
37. Bailey E, Worthington H, Coulthard P. Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth, a Cochrane systematic review. Br Dent J. 2014; 216 (8): 451–5. DOI: 10.1038/sj.bdj.2014.330
38. Alexander L, Hall E, Eriksson L, Rohlin M. The combination of non-selective NSAID 400 mg and paracetamol 1000 mg is more effective than each drug alone for treatment of acute pain. A systematic review. Swed Dent J. 2014; 38 (1): 1–14. 
39. Mehlisch DR, Asple S, Daniels SE, et al. A Single-Tablet Fixed-Dose Combination of Racemic Ibuprofen/Paracetamol in the Management of Moderate to Severe Postoperative Dental Pain in Adult and Adolescent Patients: A Multicenter, Two-Stage, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Factorial Study. Clin Ther. 2010; 32: 1033–49.
40. Moore PA, Hersh EV. Combining ibuprofen and acetaminophen for acute pain management after third-molar extractions: translating clinical research to dental practice. J Am Dent Assoc. 2013; 144 (8): 898–908. DOI: 10.14219/jada.archive.2013.0207
41. Daniels SE, Goulder MA, Aspley S, Reader S. A Randomised, Five-Parallel-Group, Placebo-Controlled Trial Comparing the Efficacy and Tolerability of Analgesic Combinations Including a Novel Single-Tablet Combination of Ibuprofen/Paracetamol for Postoperative Dental Pain. Pain. 2011; 152 (3): 632–42.
42. Doherty M, Hawkey C, Goulder M, et al. A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain. Ann Rheum Dis. 2011; 70 (9): 1534–41. DOI: 10.1136/ard.2011.154047 
43. Ostojic P, Radunovic G, Lazovic M, Tomanovic-Vujadinovic S. Ibuprofen plus paracetamol versus ibuprofen in acute low back pain: a randomized open label multicenter clinical study. Acta Reumatol Port. 2017; 42 (1): 18–25.
44. Rampal P, Moore N, Van Ganse E, et al. Gastrointestinal tolerability of ibuprofen compared with paracetamol and aspirin at over-the-counter doses. J Int Med Res. 2002; 30 (3): 301–8.
45. Strom B, Schinnar R, Bilker W, et al. Gastrointestinal tract bleeding associated with naproxen sodium vs ibuprofen. Arch Intern Med. 1997; 157 (22): 2626–31.
46. Castellsague J, Riera-Guardia N, Calingaert B, et al. Individual NSAIDs and upper gastrointestinal complications: a systematic review and meta-analysis of observational studies (the SOS project). Drug Saf. 2012; 35 (12): 1127–46. DOI: 10.2165/11633470-000000000-00000
47. Varas-Lorenzo C, Riera-Guardia N, Calingaert B, et al. Myocardial infarction and individual nonsteroidal anti-inflammatory drugs meta-analysis of observational studies. Pharmacoepidemiol Drug Saf. 2013; 22: 559–70. DOI: 10.1002/pds
48. Belousov IuB, Gurevich KG. Vliianie NPVP i paratsetamola na serdechno-sosudistuiu sistemu. Klin. farmakologicheskaia terapiia. 2002; 5: 5–7 (in Russian).
49. Karateev AE, Yakhno NN, Lazebnik LB, et al. The use of non-steroidal anti-inflammatory drugs. Clinical guidelines. Moscow: IMA-PRESS (in Russian).
50. McGettigan P, Henry D. Cardiovascular risk and inhibition of cyclooxygenase. JAMA. 2006; 296: 1633–44.

М.В. Пчелинцев*

ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России, Санкт-Петербург, Россия
*mvpchelintsev@inbox.ru

________________________________________________

Mikhail V. Pchelintsev

Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia
*mvpchelintsev@inbox.ru