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Особенности топической терапии различных форм отита у детей
Особенности топической терапии различных форм отита у детей
Радциг Е.Ю., Полунин М.М., Егина А.Д., Бондарева Д.Г. Особенности топической терапии различных форм отита у детей. Consilium Medicum. 2023;25(3):152–156. DOI: 10.26442/20751753.2023.3.202143
© ООО «КОНСИЛИУМ МЕДИКУМ», 2023 г.
© ООО «КОНСИЛИУМ МЕДИКУМ», 2023 г.
________________________________________________
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Аннотация
Разные формы отита довольно часто встречаются в педиатрической популяции. Овладение врачами первичного звена (педиатрами, семейными и общей практики) методикой отоскопии значительно расширило диагностические возможности в рамках первичного осмотра ребенка, но вместе с тем это диктует необходимость напоминать о принципах ведения пациента с различными формами отита широкому кругу специалистов. В статье отражены принципы маршрутизации и медикаментозной терапии пациентов с различными формами среднего отита. Особое внимание уделено ушным каплям (составу, показаниям к применению конкретных препаратов, в том числе с позиции безопасности и возрастного аспекта применения).
Ключевые слова: острый средний отит, острый средний перфоративный отит, ушные капли, рифамицин
Keywords: acute otitis media, acute perforative otitis media, ear drops, rifamycin
Ключевые слова: острый средний отит, острый средний перфоративный отит, ушные капли, рифамицин
________________________________________________
Keywords: acute otitis media, acute perforative otitis media, ear drops, rifamycin
Полный текст
Список литературы
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2. Nacional'naya medicinskaya associaciya otorinolaringologov. Klinicheskie rekomendacii. Minzdrava Rossii. 698. Hronicheskij srednij otit. Available at: https://cr.minzdrav.gov.ru/schema/698_1. Accessed: 23.02.2023 (in Russian).
3. Radcig EYu, Minasyan VS, Polunin MM, et al. Otit v pediatricheskoj praktike: vidy, diagnostika, differencial'nyj diagnoz, metody lecheniya. Mezhregional'noe ob"edinenie “Associaciya LOR-pediatrov”. Moscow: Izdatel'stvo “MAI-Print”, 2022 (in Russian).
4. Minasyan VS, Radcig EYu. Ostryj srednij otit: pamyatka pediatru: uchebnoe posobie. Pod red. MR Bogomil'skogo. Moscow: MAI-Print, 2018 (in Russian).
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10. DeLacy J, Dune T, Macdonald JJ. The social determinants of otitis media in aboriginal children in Australia: are we addressing the primary causes? A systematic content review. BMC Public Health. 2020;20(1):492. DOI:10.1186/s12889-020-08570-3
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15. Cetinkaya EA, Ciftci O, Alan S, et al. What is the effectiveness of beta-glucan for treatment of acute otitis media? Braz J Otorhinolaryngol. 2021;87(6):683-8. DOI:10.1016/j.bjorl.2020.02.004
16. Schwartz RH. Once-daily ofloxacin otic solution versus neomycin sulfate/polymyxin B sulfate/hydrocortisone otic suspension four times a day: a multicenter, randomized, evaluator-blinded trial to compare the efficacy, safety, and pain relief in pediatric patients with otitis externa. Curr Med Res Opin. 2006;22(9):1725-36. DOI:10.1185/030079906X121057
17. Ruben RJ. Efficacy of ofloxacin and other otic preparations for otitis externa. Pediatr Infect Dis J. 2001;20(1):108-10. DOI:10.1097/00006454-200101000-00039
18. Li S, Chen Z, Huang L, et al. Safety of Quinolones in Children: A Systematic Review and Meta-Analysis. Paediatr Drugs. 2022;24(5):447-64. DOI:10.1007/s40272-022-00513-2
19. Hussain SZM, Hashmi SS, Qayyum A. Ototoxicity of Topical Antibiotic Ear Drops in Chronic Suppurative Otitis Media in Humans: A Review of the Literature. Cureus. 2022;14(12):e32780. DOI:10.7759/cureus.32780
20. Takahashi M, Iwasaki S, Kawano T, et al. Efficacy and safety of 1.5% levofloxacin otic solution for the treatment of otitis media in a multicenter, randomized, double-blind, parallel-group, placebo-controlled, phase III study. Auris Nasus Larynx. 2023:S0385-8146(22)00242-5. DOI:10.1016/j.anl.2022.12.013
21. Wang X, Winterstein AG, Alrwisan A, Antonelli PJ. Risk for Tympanic Membrane Perforation After Quinolone Ear Drops for Acute Otitis Externa. Clin Infect Dis. 2020;70(6):1103-9. DOI:10.1093/cid/ciz345
22. Alrwisan A, Antonelli PJ, Winterstein AG. Quinolone Ear Drops After Tympanostomy Tubes and the Risk of Eardrum Perforation: A Retrospective Cohort Study. Clin Infect Dis. 2017;64(8):1052-8. DOI:10.1093/cid/cix032
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24. Liu J. The curative effect of rifampicin solution in the treatment of chronic suppurative otitis media. J Preclinical Med College Shangdong University. 2003;17(1):8-9.
25. Kiselevich OK, Radtsig EYu, Vlasova EE, et al. Tuberculosis in otorhinolaryngology in young children. Rossiiskaya otorinolaringologiya. 2021;20(6):55-9 (in Russian). DOI:10.18692/1810-4800-2021-6-55-59
26. Kryukov AI, Garov EV, Ivoilov AYu, et al. The clinical manifestations and diagnostics of otitis media caused by tuberculosis. Vestnik Oto-Rino-Laringologii. 2015;80(3):28‑34 (in Russian). DOI:10.17116/otorino201580328-34
27. Yin J, Meng Q, Cheng D, et al. Mechanisms of Bactericidal Action and Resistance of Polymyxins for Gram-Positive Bacteria. Appl Microbiol Biotechnol. 2020;104(9):3771-80. DOI:10.1007/s00253-020-10525-y
28. Lima MR, Ferreira GF, Nunes Neto WR, et al. Evaluation of the Interaction between Polymyxin B and Pseudomonas aeruginosa Biofilm and Planktonic Cells: Reactive Oxygen Species Induction and Zeta Potential. BMC Microbiol. 2019;19(1):115. DOI:10.1186/ s12866-019-1485-8
29. Mehel DM, Turgut NF, Çeviker SA, et al. Effectiveness of ciprofloxacin in the treatment of Acute Otitis Media. J Exp Clin Med. 2022;39(2):365-8. DOI:10.52142/omujecm.39.2.11
2. Национальная медицинская ассоциация оториноларингологов. Клинические рекомендации Минздрава России. 698. Хронический средний отит. Режим доступа: https://cr.minzdrav.gov.ru/schema/698_1. Ссылка активна на 23.02.2023 [Nacional'naya medicinskaya associaciya otorinolaringologov. Klinicheskie rekomendacii. Minzdrava Rossii. 698. Hronicheskij srednij otit. Available at: https://cr.minzdrav.gov.ru/schema/698_1. Accessed: 23.02.2023 (in Russian)].
3. Радциг Е.Ю., Минасян В.С., Полунин М.М., и др. Отит в педиатрической практике: виды, диагностика, дифференциальный диагноз, методы лечения. Межрегиональное объединение «Ассоциация ЛОР-педиатров». М.: Издательство «МАИ-Принт», 2022 [Radcig EYu, Minasyan VS, Polunin MM, et al. Otit v pediatricheskoj praktike: vidy, diagnostika, differencial'nyj diagnoz, metody lecheniya. Mezhregional'noe ob"edinenie “Associaciya LOR-pediatrov”. Moscow: Izdatel'stvo “MAI-Print”, 2022 (in Russian)].
4. Минасян В.С., Радциг Е.Ю. Острый средний отит: памятка педиатру: учебное пособие. Под ред. М.Р. Богомильского. М.: МАИ-Принт, 2018 [Minasyan VS, Radcig EYu. Ostryj srednij otit: pamyatka pediatru: uchebnoe posobie. Pod red. MR Bogomil'skogo. Moscow: MAI-Print, 2018 (in Russian)].
5. Богомильский М.Р. Болезни уха, горла и носа в детском возрасте: национальное руководство. Под ред. М.Р. Богомильского. 2-е изд., перераб. и доп. М.: ГЭОТАР-Медиа, 2021 [Bogomil'skij MR. Bolezni uha, gorla i nosa v detskom vozraste: nacional'noe rukovodstvo. Pod red. MR. Bogomil'skogo. 2-e izd., pererab. i dop. Moscow: GEOTAR-Media, 2021 (in Russian)].
6. Радциг Е.Ю., Минасян В.С., Титарова Л.С., и др. Этиология различных форм среднего отита у детей. Российская оториноларингология. 2015;4(77):91-5 [Radtsig EYu, Minasyan VS, Titarova LS, et al. Etiology of different forms of otitis media in children. Russian otorhinolaryngology. 2015;4(77):91-5 (in Russia)].
7. WHO Regional Office for Europe; European Centre for Disease Prevention and Control. Antimicrobial Resistance Surveillance in Europe 2022–2020 Data; WHO Regional Office for Europe: Copenhagen, Denmark, 2022. Available at: https://www.ecdc.europa.eu/en/publications-data/antimicrobial-resistance-surveillance-europe-2022-20.... Accessed: 23.02.2023.
8. Asokan GV, Ramadhan T, Ahmed E, Sanad H. WHO Global Priority Pathogens List: A Bibliometric Analysis of Medline-PubMed for Knowledge Mobilization to Infection Prevention and Control Practices in Bahrain. Oman Med J. 2019;34(3):184-93. DOI:10.5001/omj.2019.37
9. Hullegie S, Venekamp RP, van Dongen TMA, et al. Prevalence and Antimicrobial Resistance of Bacteria in Children with Acute Otitis Media and Ear Discharge: A Systematic Review. Pediatr Infect Dis J. 2021;40(8):756-62. DOI:10.1097/INF.0000000000003134
10. DeLacy J, Dune T, Macdonald JJ. The social determinants of otitis media in aboriginal children in Australia: are we addressing the primary causes? A systematic content review. BMC Public Health. 2020;20(1):492. DOI:10.1186/s12889-020-08570-3
11. Gavrilovici C, Spoială EL, Miron IC, et al. Acute Otitis Media in Children-Challenges of Antibiotic Resistance in the Post-Vaccination Era. Microorganisms. 2022;10(8):1598. DOI:10.3390/microorganisms10081598
12. Klein JO. Strategies for decreasing multidrug antibiotic resistance: role of ototopical agents for treatment of middle ear infections. Am J Manag Care. 2002;8(14 Suppl.):S345-52.
13. Weber PC, Roland PS, Hannley M, et al. The development of antibiotic resistant organisms with the use of ototopical medications. Otolaryngol Head Neck Surg. 2004;130(3 Suppl.):S89-94. DOI:10.1016/j.otohns.2003.12.009
14. Head K, Chong LY, Bhutta MF, et al. Topical antiseptics for chronic suppurative otitis media. Cochrane Database Syst Rev. 2020;1(1):CD013055. DOI:10.1002/14651858.CD013055.pub2
15. Cetinkaya EA, Ciftci O, Alan S, et al. What is the effectiveness of beta-glucan for treatment of acute otitis media? Braz J Otorhinolaryngol. 2021;87(6):683-8. DOI:10.1016/j.bjorl.2020.02.004
16. Schwartz RH. Once-daily ofloxacin otic solution versus neomycin sulfate/polymyxin B sulfate/hydrocortisone otic suspension four times a day: a multicenter, randomized, evaluator-blinded trial to compare the efficacy, safety, and pain relief in pediatric patients with otitis externa. Curr Med Res Opin. 2006;22(9):1725-36. DOI:10.1185/030079906X121057
17. Ruben RJ. Efficacy of ofloxacin and other otic preparations for otitis externa. Pediatr Infect Dis J. 2001;20(1):108-10. DOI:10.1097/00006454-200101000-00039
18. Li S, Chen Z, Huang L, et al. Safety of Quinolones in Children: A Systematic Review and Meta-Analysis. Paediatr Drugs. 2022;24(5):447-64. DOI:10.1007/s40272-022-00513-2
19. Hussain SZM, Hashmi SS, Qayyum A. Ototoxicity of Topical Antibiotic Ear Drops in Chronic Suppurative Otitis Media in Humans: A Review of the Literature. Cureus. 2022;14(12):e32780. DOI:10.7759/cureus.32780
20. Takahashi M, Iwasaki S, Kawano T, et al. Efficacy and safety of 1.5% levofloxacin otic solution for the treatment of otitis media in a multicenter, randomized, double-blind, parallel-group, placebo-controlled, phase III study. Auris Nasus Larynx. 2023:S0385-8146(22)00242-5. DOI:10.1016/j.anl.2022.12.013
21. Wang X, Winterstein AG, Alrwisan A, Antonelli PJ. Risk for Tympanic Membrane Perforation After Quinolone Ear Drops for Acute Otitis Externa. Clin Infect Dis. 2020;70(6):1103-9. DOI:10.1093/cid/ciz345
22. Alrwisan A, Antonelli PJ, Winterstein AG. Quinolone Ear Drops After Tympanostomy Tubes and the Risk of Eardrum Perforation: A Retrospective Cohort Study. Clin Infect Dis. 2017;64(8):1052-8. DOI:10.1093/cid/cix032
23. Brennan-Jones CG, Head K, Chong LY, et al. Topical antibiotics for chronic suppurative otitis media. Cochrane Database Syst Rev. 2020;1(1):CD013051. DOI:10.1002/14651858.CD013051.pub2
24. Liu J. The curative effect of rifampicin solution in the treatment of chronic suppurative otitis media. J Preclinical Med College Shangdong University. 2003;17(1):8-9.
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21. Wang X, Winterstein AG, Alrwisan A, Antonelli PJ. Risk for Tympanic Membrane Perforation After Quinolone Ear Drops for Acute Otitis Externa. Clin Infect Dis. 2020;70(6):1103-9. DOI:10.1093/cid/ciz345
22. Alrwisan A, Antonelli PJ, Winterstein AG. Quinolone Ear Drops After Tympanostomy Tubes and the Risk of Eardrum Perforation: A Retrospective Cohort Study. Clin Infect Dis. 2017;64(8):1052-8. DOI:10.1093/cid/cix032
23. Brennan-Jones CG, Head K, Chong LY, et al. Topical antibiotics for chronic suppurative otitis media. Cochrane Database Syst Rev. 2020;1(1):CD013051. DOI:10.1002/14651858.CD013051.pub2
24. Liu J. The curative effect of rifampicin solution in the treatment of chronic suppurative otitis media. J Preclinical Med College Shangdong University. 2003;17(1):8-9.
25. Kiselevich OK, Radtsig EYu, Vlasova EE, et al. Tuberculosis in otorhinolaryngology in young children. Rossiiskaya otorinolaringologiya. 2021;20(6):55-9 (in Russian). DOI:10.18692/1810-4800-2021-6-55-59
26. Kryukov AI, Garov EV, Ivoilov AYu, et al. The clinical manifestations and diagnostics of otitis media caused by tuberculosis. Vestnik Oto-Rino-Laringologii. 2015;80(3):28‑34 (in Russian). DOI:10.17116/otorino201580328-34
27. Yin J, Meng Q, Cheng D, et al. Mechanisms of Bactericidal Action and Resistance of Polymyxins for Gram-Positive Bacteria. Appl Microbiol Biotechnol. 2020;104(9):3771-80. DOI:10.1007/s00253-020-10525-y
28. Lima MR, Ferreira GF, Nunes Neto WR, et al. Evaluation of the Interaction between Polymyxin B and Pseudomonas aeruginosa Biofilm and Planktonic Cells: Reactive Oxygen Species Induction and Zeta Potential. BMC Microbiol. 2019;19(1):115. DOI:10.1186/ s12866-019-1485-8
29. Mehel DM, Turgut NF, Çeviker SA, et al. Effectiveness of ciprofloxacin in the treatment of Acute Otitis Media. J Exp Clin Med. 2022;39(2):365-8. DOI:10.52142/omujecm.39.2.11
Авторы
Е.Ю. Радциг*, М.М. Полунин, А.Д. Егина, Д.Г. Бондарева
ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия
*radtsig_e@rsmu.ru
Pirogov Russian National Research Medical University, Moscow, Russia
*radtsig_e@rsmu.ru
ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия
*radtsig_e@rsmu.ru
________________________________________________
Pirogov Russian National Research Medical University, Moscow, Russia
*radtsig_e@rsmu.ru
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