Особенности топической терапии различных форм отита у детей

Радциг Е.Ю., Полунин М.М., Егина А.Д., Бондарева Д.Г. Особенности топической терапии различных форм отита у детей. Consilium Medicum. 2023;25(3):152–156. DOI: 10.26442/20751753.2023.3.202143

© ООО «КОНСИЛИУМ МЕДИКУМ», 2023 г.

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Radtsig EIu, Polunin MM, Egina AD, Bondareva DG. Topical therapy of otitis media in children: A review. Consilium Medicum. 2023;25(3):152–156. DOI: 10.26442/20751753.2023.3.202143

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Аннотация

Разные формы отита довольно часто встречаются в педиатрической популяции. Овладение врачами первичного звена (педиатрами, семейными и общей практики) методикой отоскопии значительно расширило диагностические возможности в рамках первичного осмотра ребенка, но вместе с тем это диктует необходимость напоминать о принципах ведения пациента с различными формами отита широкому кругу специалистов. В статье отражены принципы маршрутизации и медикаментозной терапии пациентов с различными формами среднего отита. Особое внимание уделено ушным каплям (составу, показаниям к применению конкретных препаратов, в том числе с позиции безопасности и возрастного аспекта применения).

Ключевые слова: острый средний отит, острый средний перфоративный отит, ушные капли, рифамицин

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Various types of otitis are common in the pediatric population. The use of otoscopy techniques by primary care doctors (pediatricians, family, and general practitioners) has significantly expanded the diagnostic capabilities of the primary examination of the child. However, it requires many specialists to know the principles of patient management with various types of otitis media. The article addresses the principles of routing and drug therapy for patients with various types of otitis media. The focus is on ear drops (formulation, indications for using specific drugs, safety, and age-related aspects).

Keywords: acute otitis media, acute perforative otitis media, ear drops, rifamycin

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Список литературы

1. Национальная медицинская ассоциация оториноларингологов. Клинические рекомендации Минздрава России. 314. Отит средний острый. Режим доступа: https://cr.minzdrav.gov.ru/schema/314_2. Ссылка активна на 23.02.2023 [Nacional'naya medicinskaya associaciya otorinolaringologov. Klinicheskie rekomendacii Minzdrava Rossii. 314. Otit srednij ostryj. Available at: https://cr.minzdrav.gov.ru/schema/314_2. Accessed: 23.02.2023 (in Russian)].
2. Национальная медицинская ассоциация оториноларингологов. Клинические рекомендации Минздрава России. 698. Хронический средний отит. Режим доступа: https://cr.minzdrav.gov.ru/schema/698_1. Ссылка активна на 23.02.2023 [Nacional'naya medicinskaya associaciya otorinolaringologov. Klinicheskie rekomendacii. Minzdrava Rossii. 698. Hronicheskij srednij otit. Available at: https://cr.minzdrav.gov.ru/schema/698_1. Accessed: 23.02.2023 (in Russian)].
3. Радциг Е.Ю., Минасян В.С., Полунин М.М., и др. Отит в педиатрической практике: виды, диагностика, дифференциальный диагноз, методы лечения. Межрегиональное объединение «Ассоциация ЛОР-педиатров». М.: Издательство «МАИ-Принт», 2022 [Radcig EYu, Minasyan VS, Polunin MM, et al. Otit v pediatricheskoj praktike: vidy, diagnostika, differencial'nyj diagnoz, metody lecheniya. Mezhregional'noe ob"edinenie “Associaciya LOR-pediatrov”. Moscow: Izdatel'stvo “MAI-Print”, 2022 (in Russian)].
4. Минасян В.С., Радциг Е.Ю. Острый средний отит: памятка педиатру: учебное пособие. Под ред. М.Р. Богомильского. М.: МАИ-Принт, 2018 [Minasyan VS, Radcig EYu. Ostryj srednij otit: pamyatka pediatru: uchebnoe posobie. Pod red. MR Bogomil'skogo. Moscow: MAI-Print, 2018 (in Russian)].
5. Богомильский М.Р. Болезни уха, горла и носа в детском возрасте: национальное руководство. Под ред. М.Р. Богомильского. 2-е изд., перераб. и доп. М.: ГЭОТАР-Медиа, 2021 [Bogomil'skij MR. Bolezni uha, gorla i nosa v detskom vozraste: nacional'noe rukovodstvo. Pod red. MR. Bogomil'skogo. 2-e izd., pererab. i dop. Moscow: GEOTAR-Media, 2021 (in Russian)].
6. Радциг Е.Ю., Минасян В.С., Титарова Л.С., и др. Этиология различных форм среднего отита у детей. Российская оториноларингология. 2015;4(77):91-5 [Radtsig EYu, Minasyan VS, Titarova LS, et al. Etiology of different forms of otitis media in children. Russian otorhinolaryngology. 2015;4(77):91-5 (in Russia)].
7. WHO Regional Office for Europe; European Centre for Disease Prevention and Control. Antimicrobial Resistance Surveillance in Europe 2022–2020 Data; WHO Regional Office for Europe: Copenhagen, Denmark, 2022. Available at: https://www.ecdc.europa.eu/en/publications-data/antimicrobial-resistance-surveillance-europe-2022-20.... Accessed: 23.02.2023.
8. Asokan GV, Ramadhan T, Ahmed E, Sanad H. WHO Global Priority Pathogens List: A Bibliometric Analysis of Medline-PubMed for Knowledge Mobilization to Infection Prevention and Control Practices in Bahrain. Oman Med J. 2019;34(3):184-93. DOI:10.5001/omj.2019.37
9. Hullegie S, Venekamp RP, van Dongen TMA, et al. Prevalence and Antimicrobial Resistance of Bacteria in Children with Acute Otitis Media and Ear Discharge: A Systematic Review. Pediatr Infect Dis J. 2021;40(8):756-62. DOI:10.1097/INF.0000000000003134
10. DeLacy J, Dune T, Macdonald JJ. The social determinants of otitis media in aboriginal children in Australia: are we addressing the primary causes? A systematic content review. BMC Public Health. 2020;20(1):492. DOI:10.1186/s12889-020-08570-3
11. Gavrilovici C, Spoială EL, Miron IC, et al. Acute Otitis Media in Children-Challenges of Antibiotic Resistance in the Post-Vaccination Era. Microorganisms. 2022;10(8):1598. DOI:10.3390/microorganisms10081598
12. Klein JO. Strategies for decreasing multidrug antibiotic resistance: role of ototopical agents for treatment of middle ear infections. Am J Manag Care. 2002;8(14 Suppl.):S345-52.
13. Weber PC, Roland PS, Hannley M, et al. The development of antibiotic resistant organisms with the use of ototopical medications. Otolaryngol Head Neck Surg. 2004;130(3 Suppl.):S89-94. DOI:10.1016/j.otohns.2003.12.009
14. Head K, Chong LY, Bhutta MF, et al. Topical antiseptics for chronic suppurative otitis media. Cochrane Database Syst Rev. 2020;1(1):CD013055. DOI:10.1002/14651858.CD013055.pub2
15. Cetinkaya EA, Ciftci O, Alan S, et al. What is the effectiveness of beta-glucan for treatment of acute otitis media? Braz J Otorhinolaryngol. 2021;87(6):683-8. DOI:10.1016/j.bjorl.2020.02.004
16. Schwartz RH. Once-daily ofloxacin otic solution versus neomycin sulfate/polymyxin B sulfate/hydrocortisone otic suspension four times a day: a multicenter, randomized, evaluator-blinded trial to compare the efficacy, safety, and pain relief in pediatric patients with otitis externa. Curr Med Res Opin. 2006;22(9):1725-36. DOI:10.1185/030079906X121057
17. Ruben RJ. Efficacy of ofloxacin and other otic preparations for otitis externa. Pediatr Infect Dis J. 2001;20(1):108-10. DOI:10.1097/00006454-200101000-00039
18. Li S, Chen Z, Huang L, et al. Safety of Quinolones in Children: A Systematic Review and Meta-Analysis. Paediatr Drugs. 2022;24(5):447-64. DOI:10.1007/s40272-022-00513-2
19. Hussain SZM, Hashmi SS, Qayyum A. Ototoxicity of Topical Antibiotic Ear Drops in Chronic Suppurative Otitis Media in Humans: A Review of the Literature. Cureus. 2022;14(12):e32780. DOI:10.7759/cureus.32780
20. Takahashi M, Iwasaki S, Kawano T, et al. Efficacy and safety of 1.5% levofloxacin otic solution for the treatment of otitis media in a multicenter, randomized, double-blind, parallel-group, placebo-controlled, phase III study. Auris Nasus Larynx. 2023:S0385-8146(22)00242-5. DOI:10.1016/j.anl.2022.12.013
21. Wang X, Winterstein AG, Alrwisan A, Antonelli PJ. Risk for Tympanic Membrane Perforation After Quinolone Ear Drops for Acute Otitis Externa. Clin Infect Dis. 2020;70(6):1103-9. DOI:10.1093/cid/ciz345
22. Alrwisan A, Antonelli PJ, Winterstein AG. Quinolone Ear Drops After Tympanostomy Tubes and the Risk of Eardrum Perforation: A Retrospective Cohort Study. Clin Infect Dis. 2017;64(8):1052-8. DOI:10.1093/cid/cix032
23. Brennan-Jones CG, Head K, Chong LY, et al. Topical antibiotics for chronic suppurative otitis media. Cochrane Database Syst Rev. 2020;1(1):CD013051. DOI:10.1002/14651858.CD013051.pub2
24. Liu J. The curative effect of rifampicin solution in the treatment of chronic suppurative otitis media. J Preclinical Med College Shangdong University. 2003;17(1):8-9.
25. Киселевич О.К., Радциг Е.Ю., Власова Е.Е., и др. Туберкулез ЛОР-органов у детей раннего возраста. Российская оториноларингология. 2021;20(6):55-9 [Kiselevich OK, Radtsig EYu, Vlasova EE, et al. Tuberculosis in otorhinolaryngology in young children. Rossiiskaya otorinolaringologiya. 2021;20(6):55-9 (in Russian)].
DOI:10.18692/1810-4800-2021-6-55-59
26. Крюков А.И., Гаров Е.В., Ивойлов А.Ю., и др. Клинические проявления и диагностика туберкулезного среднего отита. Вестник оториноларингологии. 2015;80(3):28-34 [Kryukov AI, Garov EV, Ivoilov AYu, et al. The clinical manifestations and diagnostics of otitis media caused by tuberculosis. Vestnik Oto-Rino-Laringologii. 2015;80(3):28‑34 (in Russian)]. DOI:10.17116/otorino201580328-34
27. Yin J, Meng Q, Cheng D, et al. Mechanisms of Bactericidal Action and Resistance of Polymyxins for Gram-Positive Bacteria. Appl Microbiol Biotechnol. 2020;104(9):3771-80. DOI:10.1007/s00253-020-10525-y
28. Lima MR, Ferreira GF, Nunes Neto WR, et al. Evaluation of the Interaction between Polymyxin B and Pseudomonas aeruginosa Biofilm and Planktonic Cells: Reactive Oxygen Species Induction and Zeta Potential. BMC Microbiol. 2019;19(1):115. DOI:10.1186/ s12866-019-1485-8
29. Mehel DM, Turgut NF, Çeviker SA, et al. Effectiveness of ciprofloxacin in the treatment of Acute Otitis Media. J Exp Clin Med. 2022;39(2):365-8. DOI:10.52142/omujecm.39.2.11

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1. Nacional'naya medicinskaya associaciya otorinolaringologov. Klinicheskie rekomendacii Minzdrava Rossii. 314. Otit srednij ostryj. Available at: https://cr.minzdrav.gov.ru/schema/314_2. Accessed: 23.02.2023 (in Russian).
2. Nacional'naya medicinskaya associaciya otorinolaringologov. Klinicheskie rekomendacii. Minzdrava Rossii. 698. Hronicheskij srednij otit. Available at: https://cr.minzdrav.gov.ru/schema/698_1. Accessed: 23.02.2023 (in Russian).
3. Radcig EYu, Minasyan VS, Polunin MM, et al. Otit v pediatricheskoj praktike: vidy, diagnostika, differencial'nyj diagnoz, metody lecheniya. Mezhregional'noe ob"edinenie “Associaciya LOR-pediatrov”. Moscow: Izdatel'stvo “MAI-Print”, 2022 (in Russian).
4. Minasyan VS, Radcig EYu. Ostryj srednij otit: pamyatka pediatru: uchebnoe posobie. Pod red. MR Bogomil'skogo. Moscow: MAI-Print, 2018 (in Russian).
5. Bogomil'skij MR. Bolezni uha, gorla i nosa v detskom vozraste: nacional'noe rukovodstvo. Pod red. MR. Bogomil'skogo. 2-e izd., pererab. i dop. Moscow: GEOTAR-Media, 2021 (in Russian).
6. Radtsig EYu, Minasyan VS, Titarova LS, et al. Etiology of different forms of otitis media in children. Russian otorhinolaryngology. 2015;4(77):91-5 (in Russia).
7. WHO Regional Office for Europe; European Centre for Disease Prevention and Control. Antimicrobial Resistance Surveillance in Europe 2022–2020 Data; WHO Regional Office for Europe: Copenhagen, Denmark, 2022. Available at: https://www.ecdc.europa.eu/en/publications-data/antimicrobial-resistance-surveillance-europe-2022-20.... Accessed: 23.02.2023.
8. Asokan GV, Ramadhan T, Ahmed E, Sanad H. WHO Global Priority Pathogens List: A Bibliometric Analysis of Medline-PubMed for Knowledge Mobilization to Infection Prevention and Control Practices in Bahrain. Oman Med J. 2019;34(3):184-93. DOI:10.5001/omj.2019.37
9. Hullegie S, Venekamp RP, van Dongen TMA, et al. Prevalence and Antimicrobial Resistance of Bacteria in Children with Acute Otitis Media and Ear Discharge: A Systematic Review. Pediatr Infect Dis J. 2021;40(8):756-62. DOI:10.1097/INF.0000000000003134
10. DeLacy J, Dune T, Macdonald JJ. The social determinants of otitis media in aboriginal children in Australia: are we addressing the primary causes? A systematic content review. BMC Public Health. 2020;20(1):492. DOI:10.1186/s12889-020-08570-3
11. Gavrilovici C, Spoială EL, Miron IC, et al. Acute Otitis Media in Children-Challenges of Antibiotic Resistance in the Post-Vaccination Era. Microorganisms. 2022;10(8):1598. DOI:10.3390/microorganisms10081598
12. Klein JO. Strategies for decreasing multidrug antibiotic resistance: role of ototopical agents for treatment of middle ear infections. Am J Manag Care. 2002;8(14 Suppl.):S345-52.
13. Weber PC, Roland PS, Hannley M, et al. The development of antibiotic resistant organisms with the use of ototopical medications. Otolaryngol Head Neck Surg. 2004;130(3 Suppl.):S89-94. DOI:10.1016/j.otohns.2003.12.009
14. Head K, Chong LY, Bhutta MF, et al. Topical antiseptics for chronic suppurative otitis media. Cochrane Database Syst Rev. 2020;1(1):CD013055. DOI:10.1002/14651858.CD013055.pub2
15. Cetinkaya EA, Ciftci O, Alan S, et al. What is the effectiveness of beta-glucan for treatment of acute otitis media? Braz J Otorhinolaryngol. 2021;87(6):683-8. DOI:10.1016/j.bjorl.2020.02.004
16. Schwartz RH. Once-daily ofloxacin otic solution versus neomycin sulfate/polymyxin B sulfate/hydrocortisone otic suspension four times a day: a multicenter, randomized, evaluator-blinded trial to compare the efficacy, safety, and pain relief in pediatric patients with otitis externa. Curr Med Res Opin. 2006;22(9):1725-36. DOI:10.1185/030079906X121057
17. Ruben RJ. Efficacy of ofloxacin and other otic preparations for otitis externa. Pediatr Infect Dis J. 2001;20(1):108-10. DOI:10.1097/00006454-200101000-00039
18. Li S, Chen Z, Huang L, et al. Safety of Quinolones in Children: A Systematic Review and Meta-Analysis. Paediatr Drugs. 2022;24(5):447-64. DOI:10.1007/s40272-022-00513-2
19. Hussain SZM, Hashmi SS, Qayyum A. Ototoxicity of Topical Antibiotic Ear Drops in Chronic Suppurative Otitis Media in Humans: A Review of the Literature. Cureus. 2022;14(12):e32780. DOI:10.7759/cureus.32780
20. Takahashi M, Iwasaki S, Kawano T, et al. Efficacy and safety of 1.5% levofloxacin otic solution for the treatment of otitis media in a multicenter, randomized, double-blind, parallel-group, placebo-controlled, phase III study. Auris Nasus Larynx. 2023:S0385-8146(22)00242-5. DOI:10.1016/j.anl.2022.12.013
21. Wang X, Winterstein AG, Alrwisan A, Antonelli PJ. Risk for Tympanic Membrane Perforation After Quinolone Ear Drops for Acute Otitis Externa. Clin Infect Dis. 2020;70(6):1103-9. DOI:10.1093/cid/ciz345
22. Alrwisan A, Antonelli PJ, Winterstein AG. Quinolone Ear Drops After Tympanostomy Tubes and the Risk of Eardrum Perforation: A Retrospective Cohort Study. Clin Infect Dis. 2017;64(8):1052-8. DOI:10.1093/cid/cix032
23. Brennan-Jones CG, Head K, Chong LY, et al. Topical antibiotics for chronic suppurative otitis media. Cochrane Database Syst Rev. 2020;1(1):CD013051. DOI:10.1002/14651858.CD013051.pub2
24. Liu J. The curative effect of rifampicin solution in the treatment of chronic suppurative otitis media. J Preclinical Med College Shangdong University. 2003;17(1):8-9.
25. Kiselevich OK, Radtsig EYu, Vlasova EE, et al. Tuberculosis in otorhinolaryngology in young children. Rossiiskaya otorinolaringologiya. 2021;20(6):55-9 (in Russian). DOI:10.18692/1810-4800-2021-6-55-59
26. Kryukov AI, Garov EV, Ivoilov AYu, et al. The clinical manifestations and diagnostics of otitis media caused by tuberculosis. Vestnik Oto-Rino-Laringologii. 2015;80(3):28‑34 (in Russian). DOI:10.17116/otorino201580328-34
27. Yin J, Meng Q, Cheng D, et al. Mechanisms of Bactericidal Action and Resistance of Polymyxins for Gram-Positive Bacteria. Appl Microbiol Biotechnol. 2020;104(9):3771-80. DOI:10.1007/s00253-020-10525-y
28. Lima MR, Ferreira GF, Nunes Neto WR, et al. Evaluation of the Interaction between Polymyxin B and Pseudomonas aeruginosa Biofilm and Planktonic Cells: Reactive Oxygen Species Induction and Zeta Potential. BMC Microbiol. 2019;19(1):115. DOI:10.1186/ s12866-019-1485-8
29. Mehel DM, Turgut NF, Çeviker SA, et al. Effectiveness of ciprofloxacin in the treatment of Acute Otitis Media. J Exp Clin Med. 2022;39(2):365-8. DOI:10.52142/omujecm.39.2.11

Авторы

Е.Ю. Радциг*, М.М. Полунин, А.Д. Егина, Д.Г. Бондарева

ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия
*radtsig_e@rsmu.ru

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Elena Iu. Radtsig*, Mikhail M. Polunin, Anastasiia D. Egina, Daria G. Bondareva

Pirogov Russian National Research Medical University, Moscow, Russia
*radtsig_e@rsmu.ru

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