Заболевания почек, связанные с ВИЧ-инфекцией и коинфекцией вирусными гепатитами В и С

Мартынов А.Ю., Кривушкин С.А., Иркабаева М.М., Черенкова Д.О. Заболевания почек, связанные с ВИЧ-инфекцией и коинфекцией вирусными гепатитами В и С. Consilium Medicum. 2024;26(10):684–691.
DOI: 10.26442/20751753.2024.10.202670

© ООО «КОНСИЛИУМ МЕДИКУМ», 2024 г.

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Martynov AYu, Krivushkin SA, Irkabaeva MM, Cherenkova DO. The kidney diseases associated with HIV infection and coinfection with viral hepatitis B and C. Case report. Consilium Medicum. 2024;26(10):684–691.
DOI: 10.26442/20751753.2024.10.202670

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Аннотация

В статье представлены основные патоморфологические, патогенетические, классификационные, диагностические сведения и клинические случаи заболеваний почек, развивающихся на фоне ВИЧ-инфекции и коинфекции вирусными гепатитами В и С. Приведены 2 наблюдения волчаночноподобного гломерулонефрита и редкий случай С3-гломерулопатии на фоне ВИЧ, характеризующиеся различной тяжестью течения и разнообразной клинической картиной поражения почек, демонстрирующие роль не только изолированной ВИЧ-инфекции, но и коинфекции вирусными гепатитами В и С в поражении клубочков почек.

Ключевые слова: ВИЧ, заболевания почек, коинфекция вирусным гепатитом В, коинфекция вирусным гепатитом С, волчаночноподобный гломерулонефрит, С3-гломерулопатия

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The article presents the main pathomorphological, pathogenetic, classification, diagnostic information and clinical cases of kidney disease in patients with HIV infection and viral hepatitis B and C coinfection. Two cases of lupus-like glomerulonephritis and a rare case of C3-glomerulopathy due to HIV are described, which characterized by different disease severity and a diverse kidney damage clinical manifestation, demonstrating the role of isolated HIV infection and coinfection with viral hepatitis B and C in glomerular injury.

Keywords: HIV, kidney disease, coinfection with viral hepatitis B, coinfection with viral hepatitis C, lupus-like glomerulonephritis, C3-glomerulopathy

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Список литературы

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2. Wyatt CM. Kidney Disease and HIV Infection. Top Antivir Med. 2017;25(1):13-6.
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4. Swanepoel CR, Atta MG, D'Agati VD, et al. Kidney disease in the setting of HIV infection: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2018;93(3):545-59. DOI:10.1016/j.kint.2017.11.007
5. Diana NE, Davies M, Mosiane P, et al. Clinicopathological correlation of kidney disease in HIV infection pre- and post-ART rollout. PLoS One. 2022;17(5):e0269260. DOI:10.1371/journal.pone.0269260
6. Herman ES, Klotman PE. HIV-associated nephropathy: Epidemiology, pathogenesis, and treatment. Semin Nephrol. 2003;23(2):200-8. DOI:10.1053/snep.2003.50018
7. Eitner F, Cui Y, Hudkins KL, et al. Chemokine receptor CCR5 and CXCR4 expression in HIV-associated kidney disease. J Am Soc Nephrol. 2000;11(5):856-67. DOI:10.1681/ASN.V115856
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10. Mikulak J, Singhal PC. HIV-1 entry into human podocytes is mediated through lipid rafts. Kidney Int. 2010;77(1):72-3. DOI:10.1038/ki.2009.366
11. Khatua AK, Taylor HE, Hildreth JE, Popik W. Non-productive HIV-1 infection of human glomerular and urinary podocytes. Virology. 2010;408(1):119-27. DOI:10.1016/j.virol.2010.09.005
12. Li J, Das JR, Tang P, et al. Transmembrane TNF-α Facilitates HIV-1 Infection of Podocytes Cultured from Children with HIV-Associated Nephropathy. J Am Soc Nephrol. 2017;28(3):862-75. DOI:10.1681/ASN.2016050564
13. Limou S, Nelson GW, Lecordier L, et al. Sequencing rare and common APOL1 coding variants to determine kidney disease risk. Kidney Int. 2015;88(4):754-63. DOI:10.1038/ki.2015.151
14. Atta MG. Diagnosis and natural history of HIV-associated nephropathy. Adv Chronic Kidney Dis. 2010;17(1):52-8. DOI:10.1053/j.ackd.2009.08.005
15. Burns GC, Paul SK, Toth IR, Sivak SL. Effect of angiotensin-converting enzyme inhibition in HIV-associated nephropathy. J Am Soc Nephrol. 1997;8(7):1140-6. DOI:10.1681/ASN.V871140
16. Nochy D, Glotz D, Dosquet P, et al. Renal disease associated with HIV infection: a multicentric study of 60 patients from Paris hospitals. Nephrol Dial Transplant. 1993;8(1):11-9. DOI:10.1093/oxfordjournals.ndt.a092263
17. Haas M, Kaul S, Eustace JA. HIV-associated immune complex glomerulonephritis with "lupus-like" features: a clinicopathologic study of 14 cases. Kidney Int. 2005;67(4):1381-90. DOI:10.1111/j.1523-1755.2005.00215.x
18. Cohen SD, Kimmel PL. Immune complex renal disease and human immunodeficiency virus infection. Semin Nephrol. 2008;28(6):535-44. DOI:10.1016/j.semnephrol.2008.08.006
19. Tiong M, Wilson S, Pham A, Chrysostomou A. Successful treatment of HIV-associated lupus-like glomerulonephritis with mycophenolic acid. Clin Case Rep. 2020;8(9):1601-4. DOI:10.1002/ccr3.2955
20. Kimmel PL, Phillips TM, Ferreira-Centeno A, et al. HIV-associated immune-mediated renal disease. Kidney Int. 1993;44(6):1327-40. DOI:10.1038/ki.1993.386
21. Charu V, Andeen N, Walavalkar V, et al. Membranous nephropathy in patients with HIV: a report of 11 cases. BMC Nephrol. 2020;21(1):401. DOI:10.1186/s12882-020-02042-x
22. Cook HT, Pickering MC. Clusters Not Classifications: Making Sense of Complement-Mediated Kidney Injury. J Am Soc Nephrol. 2018;29(1):9-12. DOI:10.1681/ASN.2017111183
23. Schena FP, Esposito P, Rossini M. A Narrative Review on C3 Glomerulopathy: A Rare Renal Disease. Int J Mol Sci. 2020;21(2). DOI:10.3390/ijms21020525
24. Mazzaro C, Adinolfi LE, Pozzato G, et al. Extrahepatic Manifestations of Chronic HBV Infection and the Role of Antiviral Therapy. J Clin Med. 2022;11(21). DOI:10.3390/jcm11216247
25. Lai KN, Li PK, Lui SF, et al. Membranous nephropathy related to hepatitis B virus in adults. N Engl J Med. 1991;324(21):1457-63. DOI:10.1056/NEJM199105233242103
26. Kamar N, Rostaing L, Alric L. Treatment of hepatitis C-virus-related glomerulonephritis. Kidney Int. 2006;69(3):436-9. DOI:10.1038/sj.ki.5000142
27. da Mata GF, Fernandes DE, Luciano EP, et al. Inflammation and kidney involvement in human viral diseases caused by SARS-CoV-2, HIV, HCV and HBV. J Venom Anim Toxins Incl Trop Dis. 2021;27:e20200154. DOI:10.1590/1678-9199-JVATITD-2020-0154
28. Saha MK, Julian BA, Novak J, Rizk DV. Secondary IgA nephropathy. Kidney Int. 2018;94(4):674-81. DOI:10.1016/j.kint.2018.02.030
29. Shen H, French BA, Liu H, et al. Increased activity of the complement system in the liver of patients with alcoholic hepatitis. Exp Mol Pathol. 2014;97(3):338-44. DOI:10.1016/j.yexmp.2014.09.004
30. Wyatt CM, Malvestutto C, Coca SG, et al. The impact of hepatitis C virus coinfection on HIV-related kidney disease: a systematic review and meta-analysis. AIDS.
2008;22(14):1799-807. DOI:10.1097/QAD.0b013e32830e0152
31. Izzedine H, Sene D, Cacoub P, et al. Kidney diseases in HIV/HCV-co-infected patients. AIDS. 2009;23(10):1219-26. DOI:10.1097/QAD.0b013e32832ac36a
32. Mocroft A, Neuhaus J, Peters L, et al. Hepatitis B and C co-infection are independent predictors of progressive kidney disease in HIV-positive, antiretroviral-treated adults. PLoS One. 2012;7(7):e40245. DOI:10.1371/journal.pone.0040245
33. Kawakita C, Kinomura M, Otaka N, et al. HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy. Intern Med. 2019;58(20):3001-7. DOI:10.2169/internalmedicine.2439-18
34. Uthman IW, Gharavi AE. Viral infections and antiphospholipid antibodies. Semin Arthritis Rheum. 2002;31(4):256-63. DOI:10.1053/sarh.2002.28303
35. Ankri A, Bonmarchand M, Coutellier A, et al. Antiphospholipid antibodies are an epiphenomenon in HIV-infected patients. AIDS. 1999;13(10):1282-3.
DOI:10.1097/00002030-199907090-00024

________________________________________________

1. VICh-infektsiia v Rossiiskoi Federatsii na 30 iiunia 2023 g. Available at: https://files.antispidnn.ru/uploads/docs/spec/vich2023.pdf. Accessed: 12.02.2024 (in Russian).
2. Wyatt CM. Kidney Disease and HIV Infection. Top Antivir Med. 2017;25(1):13-6.
3. Kudose S, Santoriello D, Bomback AS, et al. The spectrum of kidney biopsy findings in HIV-infected patients in the modern era. Kidney Int. 2020;97(5):1006-16. DOI:10.1016/j.kint.2020.01.018
4. Swanepoel CR, Atta MG, D'Agati VD, et al. Kidney disease in the setting of HIV infection: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2018;93(3):545-59. DOI:10.1016/j.kint.2017.11.007
5. Diana NE, Davies M, Mosiane P, et al. Clinicopathological correlation of kidney disease in HIV infection pre- and post-ART rollout. PLoS One. 2022;17(5):e0269260. DOI:10.1371/journal.pone.0269260
6. Herman ES, Klotman PE. HIV-associated nephropathy: Epidemiology, pathogenesis, and treatment. Semin Nephrol. 2003;23(2):200-8. DOI:10.1053/snep.2003.50018
7. Eitner F, Cui Y, Hudkins KL, et al. Chemokine receptor CCR5 and CXCR4 expression in HIV-associated kidney disease. J Am Soc Nephrol. 2000;11(5):856-67. DOI:10.1681/ASN.V115856
8. Bracq L, Xie M, Benichou S, Bouchet J. Mechanisms for Cell-to-Cell Transmission of HIV-1. Front Immunol. 2018;9:260. DOI:10.3389/fimmu.2018.00260
9. Eugenin EA, Gaskill PJ, Berman JW. Tunneling nanotubes (TNT) are induced by HIV-infection of macrophages: a potential mechanism for intercellular HIV trafficking. Cell Immunol. 2009;254(2):142-8. DOI:10.1016/j.cellimm.2008.08.005
10. Mikulak J, Singhal PC. HIV-1 entry into human podocytes is mediated through lipid rafts. Kidney Int. 2010;77(1):72-3. DOI:10.1038/ki.2009.366
11. Khatua AK, Taylor HE, Hildreth JE, Popik W. Non-productive HIV-1 infection of human glomerular and urinary podocytes. Virology. 2010;408(1):119-27. DOI:10.1016/j.virol.2010.09.005
12. Li J, Das JR, Tang P, et al. Transmembrane TNF-α Facilitates HIV-1 Infection of Podocytes Cultured from Children with HIV-Associated Nephropathy. J Am Soc Nephrol. 2017;28(3):862-75. DOI:10.1681/ASN.2016050564
13. Limou S, Nelson GW, Lecordier L, et al. Sequencing rare and common APOL1 coding variants to determine kidney disease risk. Kidney Int. 2015;88(4):754-63. DOI:10.1038/ki.2015.151
14. Atta MG. Diagnosis and natural history of HIV-associated nephropathy. Adv Chronic Kidney Dis. 2010;17(1):52-8. DOI:10.1053/j.ackd.2009.08.005
15. Burns GC, Paul SK, Toth IR, Sivak SL. Effect of angiotensin-converting enzyme inhibition in HIV-associated nephropathy. J Am Soc Nephrol. 1997;8(7):1140-6. DOI:10.1681/ASN.V871140
16. Nochy D, Glotz D, Dosquet P, et al. Renal disease associated with HIV infection: a multicentric study of 60 patients from Paris hospitals. Nephrol Dial Transplant. 1993;8(1):11-9. DOI:10.1093/oxfordjournals.ndt.a092263
17. Haas M, Kaul S, Eustace JA. HIV-associated immune complex glomerulonephritis with "lupus-like" features: a clinicopathologic study of 14 cases. Kidney Int. 2005;67(4):1381-90. DOI:10.1111/j.1523-1755.2005.00215.x
18. Cohen SD, Kimmel PL. Immune complex renal disease and human immunodeficiency virus infection. Semin Nephrol. 2008;28(6):535-44. DOI:10.1016/j.semnephrol.2008.08.006
19. Tiong M, Wilson S, Pham A, Chrysostomou A. Successful treatment of HIV-associated lupus-like glomerulonephritis with mycophenolic acid. Clin Case Rep. 2020;8(9):1601-4. DOI:10.1002/ccr3.2955
20. Kimmel PL, Phillips TM, Ferreira-Centeno A, et al. HIV-associated immune-mediated renal disease. Kidney Int. 1993;44(6):1327-40. DOI:10.1038/ki.1993.386
21. Charu V, Andeen N, Walavalkar V, et al. Membranous nephropathy in patients with HIV: a report of 11 cases. BMC Nephrol. 2020;21(1):401. DOI:10.1186/s12882-020-02042-x
22. Cook HT, Pickering MC. Clusters Not Classifications: Making Sense of Complement-Mediated Kidney Injury. J Am Soc Nephrol. 2018;29(1):9-12. DOI:10.1681/ASN.2017111183
23. Schena FP, Esposito P, Rossini M. A Narrative Review on C3 Glomerulopathy: A Rare Renal Disease. Int J Mol Sci. 2020;21(2). DOI:10.3390/ijms21020525
24. Mazzaro C, Adinolfi LE, Pozzato G, et al. Extrahepatic Manifestations of Chronic HBV Infection and the Role of Antiviral Therapy. J Clin Med. 2022;11(21). DOI:10.3390/jcm11216247
25. Lai KN, Li PK, Lui SF, et al. Membranous nephropathy related to hepatitis B virus in adults. N Engl J Med. 1991;324(21):1457-63. DOI:10.1056/NEJM199105233242103
26. Kamar N, Rostaing L, Alric L. Treatment of hepatitis C-virus-related glomerulonephritis. Kidney Int. 2006;69(3):436-9. DOI:10.1038/sj.ki.5000142
27. da Mata GF, Fernandes DE, Luciano EP, et al. Inflammation and kidney involvement in human viral diseases caused by SARS-CoV-2, HIV, HCV and HBV. J Venom Anim Toxins Incl Trop Dis. 2021;27:e20200154. DOI:10.1590/1678-9199-JVATITD-2020-0154
28. Saha MK, Julian BA, Novak J, Rizk DV. Secondary IgA nephropathy. Kidney Int. 2018;94(4):674-81. DOI:10.1016/j.kint.2018.02.030
29. Shen H, French BA, Liu H, et al. Increased activity of the complement system in the liver of patients with alcoholic hepatitis. Exp Mol Pathol. 2014;97(3):338-44. DOI:10.1016/j.yexmp.2014.09.004
30. Wyatt CM, Malvestutto C, Coca SG, et al. The impact of hepatitis C virus coinfection on HIV-related kidney disease: a systematic review and meta-analysis. AIDS.
2008;22(14):1799-807. DOI:10.1097/QAD.0b013e32830e0152
31. Izzedine H, Sene D, Cacoub P, et al. Kidney diseases in HIV/HCV-co-infected patients. AIDS. 2009;23(10):1219-26. DOI:10.1097/QAD.0b013e32832ac36a
32. Mocroft A, Neuhaus J, Peters L, et al. Hepatitis B and C co-infection are independent predictors of progressive kidney disease in HIV-positive, antiretroviral-treated adults. PLoS One. 2012;7(7):e40245. DOI:10.1371/journal.pone.0040245
33. Kawakita C, Kinomura M, Otaka N, et al. HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy. Intern Med. 2019;58(20):3001-7. DOI:10.2169/internalmedicine.2439-18
34. Uthman IW, Gharavi AE. Viral infections and antiphospholipid antibodies. Semin Arthritis Rheum. 2002;31(4):256-63. DOI:10.1053/sarh.2002.28303
35. Ankri A, Bonmarchand M, Coutellier A, et al. Antiphospholipid antibodies are an epiphenomenon in HIV-infected patients. AIDS. 1999;13(10):1282-3.
DOI:10.1097/00002030-199907090-00024

Авторы

А.Ю. Мартынов*¹, С.А. Кривушкин², М.М. Иркабаева¹, Д.О. Черенкова³

¹ФГАОУ ВО «Российский университет дружбы народов им. Патриса Лумумбы», Москва, Россия;
²ГБУЗ «Городская клиническая больница им. С.С. Юдина» Департамента здравоохранения г. Москвы, Москва, Россия;
³ФГБУ «Российский научный центр рентгенорадиологии» Минздрава России, Москва, Россия
*martynov-ayu@rudn.ru

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Alexey Yu. Martynov*¹, Sergey A. Krivushkin², Malika M. Irkabaeva¹, Darya O. Cherenkova³

¹Patrice Lumumba People’s Friendship University of Russia, Moscow, Russia;
²Moscow City Hospital named after S.S. Yudin, Moscow Healthcare Department, Moscow, Russia;
³Russian Scientific Center of Roentgenology and Radiology, Moscow, Russia
*martynov-ayu@rudn.ru

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