Ievlev EN, Bekhtereva DR, Khuzina ZR, Chalgubaev EK, Chekmareva IN. Clinical case of mechanical and non-mechanical rhabdomyolysis complicated by acute kidney injury. Case report. Consilium Medicum.
2024;26(1):45–47. DOI: 10.26442/20751753.2024.1.202634
Клинический случай рабдомиолиза механической и немеханической природы, осложнившегося острым повреждением почек
Иевлев Е.Н., Бехтерева Д.Р., Хузина З.Р., Чалгубаев Э.К., Чекмарева И.Н. Клинический случай рабдомиолиза механической и немеханической природы, осложнившегося острым повреждением почек. Consilium Medicum. 2024;26(1):45–47. DOI: 10.26442/20751753.2024.1.202634
Ievlev EN, Bekhtereva DR, Khuzina ZR, Chalgubaev EK, Chekmareva IN. Clinical case of mechanical and non-mechanical rhabdomyolysis complicated by acute kidney injury. Case report. Consilium Medicum.
2024;26(1):45–47. DOI: 10.26442/20751753.2024.1.202634
До настоящего времени в России остается актуальной проблема рабдомиолиза. Несмотря на внедрение современных методов диагностики, профилактики и лечения, летальность остается высокой, до 40%, особенно при присоединении острого повреждения почек (ОПП). В статье представлен клинический случай рабдомиолиза, который возник в результате сочетанного воздействия нетравматических (токсического действия метадона, алкоголя) и травматических (вибрации и нефизиологического положения во время сна) факторов. Данный синдром в конечном итоге привел к развитию ОПП вплоть до анурии. В представленном клиническом случае проведена интенсивная инфузионная и дезинтоксикационная терапия, в том числе процедуры гемодиализа, что привело к практически полному восстановлению функционального состояния почек. Таким образом, ранняя диагностика рабдомиолиза и ОПП, основанная на анамнезе, своевременной лабораторно-инструментальной диагностике, может предотвратить тяжелое повреждение почек вплоть до терминальной уремии и фатальных последствий.
To date, the problem of rhabdomyolysis remains relevant in Russia. Despite the introduction of modern methods of diagnosis, prevention and treatment, mortality remains high, up to 40%, especially with the addition of acute kidney injury. This article presents a clinical case of rhabdomyolysis, which arose as a result of the combined effects of non-traumatic (toxic effects of methadone, alcohol) and traumatic (vibration and non-physiological position during sleep) factors. This syndrome eventually led to the development of acute kidney damage up to anuria. In this clinical case, intensive infusion and detoxification therapy, including hemodialysis procedures, was carried out, which led to an almost complete restoration of the functional state of the kidneys. Thus, early diagnosis of rhabdomyolysis and AKI based on anamnesis, timely laboratory and instrumental diagnosis can prevent severe kidney damage up to terminal uremia and fatal consequences.
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21. Hui WF, Hon KL, Lun KS, et al. Successful treatment of rhabdomyolysis-associated acute kidney injury with haemoadsorption and continuous renal replacement therapy. Case Rep Pediatr. 2021;2021:2148024. DOI:10.1155/2021/2148024
22. Long B, Koyfman A, Gottlieb M. An evidence-based narrative review of the emergency department evaluation and management of rhabdomyolysis. Am J Emerg Med. 2019;37(3):518-23. DOI:10.1016/j.ajem.2018.12.061
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1. Młynarska E, Krzemińska J, Wronka M, et al. Rhabdomyolysis-Induced AKI (RIAKI) Including the Role of COVID-19. Int J Mol Sci. 2022;23(15):8215. DOI:10.3390/ijms23158215
2. Boudhabhay I, Poillerat V, Grunenwald A, et al. Complement activation is a crucial driver of acute kidney injury in rhabdomyolysis. Kidney Int. 2021;99(3):581-97. DOI:10.1016/j.kint.2020.09.033
3. Saverymuthu A, Teo R, Zain JM, et al. Acute kidney injury following rhabdomyolysis in critically ill patients. J Crit Care Med. 2021;7(4):267-71. DOI:10.2478/jccm-2021-0025
4. Stahl K, Rastelli E, Schoser B. A systematic review on the definition of rhabdomyolysis. J Neurol. 2020;267(4):877-82. DOI:10.1007/s00415-019-09185-4
5. Bosch X, Poch E, Grau JM. Rhabdomyolysis and acute kidney injury. New Engl J Med. 2009;361(1):62-72. DOI:10.1056/NEJMra0801327
6. Petejova N, Martinek A. Acute kidney injury due to rhabdomyolysis and renal replacement therapy: a critical review. Crit Care. 2014;18(3):224. DOI:10.1186/cc13897
7. Kwiatkowska M, Chomicka I, Malyszko J. Rhabdomyoisis – induced acute kidney injury – an underestimated problem. Wiadomosci lekarskie. 2020;73(11):2543-8.
8. Weidhase L, Haussig E, Haussig S, et al. Middle molecule clearance with high cut-off dialyzer versus high-flux dialyzer using continuous veno-venous hemodialysis with regional citrate anticoagulation: a prospective randomized controlled trial. PloS One. 2019;14(4):0215823. DOI:10.1371/journal.pone.0215823
9. Esnazarova GS, Omarova HS, Shamshidinova MA, et al. Clinical case of rhabdomyolysis. Medicine (Almaty). 2016;2(164):55-7 (in Russian).
10. Iskova IA, Klaritskaya IL, Tsapyak TA, et al. Statin-induced myopathy. Crimean Journal of Internal Diseases. 2021;3:64-70 (in Russian).
11. Kuznetsov OA, Lodyagin AN, Batotsyrenov BV, et al. Features of the clinical course of acute methadone poisoning complicated by the development of positional compression syndrome and systemic rhabdomyolysis. Toxicological Review. 2015;4(133):38-43 (in Russian).
12. Berdnikov GA, Kudryashova NE, Migunova EV, et al. Development of rhabdomyolysis in the long-term period of Previous new coronavirus infection covid-19 (Clinical case report). Russian Sklifosovsky Journal "Emergency Medical Care". 2021;10(3):452-9 (in Russian). DOI:10.23934/2223-9022-2021-10-3-452-459
13. Borisov AG, Chernov SA, Potekhin NP, Romanov VP. Nontraumatic rhabdomyolysis as the reason of acute renal injury. Nephrology. 2019;23((Suppl. 1):44-5 (in Russian). DOI:10.36485/1561-6274-2019-23-5-44-54
14. Ghasemi S, Izadpanahi S, Yaghoubi MA, et al. Methadone associated long term hearing loss and nephrotoxicity; a case report and literature review. Subst Abuse Treat Prev Policy. 2019;14(1):48. DOI:10.1186/s13011-019-0236-z
15. Alinejad S, Ghaemi K, Abdollahi M, Mehrpour O. Nephrotoxicity of methadone: a systematic review. Springerplus. 2016;5(1):2087. DOI:10.1186/s40064-016-3757-1
16. Volkov EV, Gurov AY, Fischer VV, Batchaeva LH. Сase of providing medical care to a patient with atypical onset of traumatic rhabdomyolysis syndrome. Siberian Medical Review. 2020;2(122):98-102 (in Russian). DOI:10.20333/2500136-2020-2-98-102
17. Donskoy DN. Rhabdomyolysis as a cause of acute kidney injury in childhood. Innovation Science. 2021;7:148-9 (in Russian).
18. Ould-Nana I, Cillis M, Gizzi M, et al. Rhabdomyolysis and acute kidney injury induced by the association of rosuvastatin and abiraterone: A case report and review of the literature. J Oncol Pharm Pract. 2021;27(1):216-9. DOI:10.1177/1078155220923001
19. Fedorova AA, Kutepov DE, Zubarev AV, et al. Rhabdomyolysis: What's new in diagnostics and treatment? Kremlin Medicine Journal. 2020;2:102-9 (in Russian).
DOI:10.26269/4n94-0746
20. Sawhney JS, Kasotakis G, Goldenberg A, et al. Management of rhabdomyolysis: A practice management guideline from the Eastern Association for the Surgery of Trauma. Am J Surg. 2022;224(1 Pt A):196-204. DOI:10.1016/j.amjsurg.2021.11.022
21. Hui WF, Hon KL, Lun KS, et al. Successful treatment of rhabdomyolysis-associated acute kidney injury with haemoadsorption and continuous renal replacement therapy. Case Rep Pediatr. 2021;2021:2148024. DOI:10.1155/2021/2148024
22. Long B, Koyfman A, Gottlieb M. An evidence-based narrative review of the emergency department evaluation and management of rhabdomyolysis. Am J Emerg Med. 2019;37(3):518-23. DOI:10.1016/j.ajem.2018.12.061
1ФГБОУ ВО «Ижевская государственная медицинская академия» Минздрава России, Ижевск, Россия; 2БУЗ УР «Городская клиническая больница №6» Минздрава Удмуртской Республики, Ижевск, Россия
*zuhra-huzina@mail.ru
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Evgeniy N. Ievlev1, Daria R. Bekhtereva1, Zukhra R. Khuzina*1, Edgar K. Chalgubaev2, Irina N. Chekmareva2
1Izhevsk State Medical Academy, Izhevsk, Russia; 2City Clinical Hospital №6, Izhevsk, Russia
*zuhra-huzina@mail.ru