Материалы доступны только для специалистов сферы здравоохранения. Авторизуйтесь или зарегистрируйтесь.
Эффективность применения витаминов группы B у пациентов с диабетической полинейропатией
Эффективность применения витаминов группы B у пациентов с диабетической полинейропатией
Трухан Д.И., Друк И.В. Эффективность применения витаминов группы B у пациентов с диабетической полинейропатией. Consilium Medicum. 2024;26(4):269–275. DOI: 10.26442/20751753.2024.4.202756
© ООО «КОНСИЛИУМ МЕДИКУМ», 2024 г.
© ООО «КОНСИЛИУМ МЕДИКУМ», 2024 г.
________________________________________________
Материалы доступны только для специалистов сферы здравоохранения. Авторизуйтесь или зарегистрируйтесь.
Аннотация
Последние десятилетия ознаменовались бурным ростом числа больных, страдающих сахарным диабетом (СД). Наибольшее влияние на прогноз жизни у пациентов с СД оказывают развитие и прогрессирование осложнений заболевания. Одним из частых осложнений СД является диабетическая полинейропатия (ДПН). По оценкам экспертов, ДПН развивается у 50% больных СД и у 10–30% пациентов в предиабетическом состоянии. В отечественных клинических рекомендациях и алгоритмах вопросы терапии ДПН рассматриваются только в аспекте препаратов, применяемых для лечения ее болевой формы. В рекомендациях международных экспертов важное место занимает патогенетически ориентированная фармакотерапия (α-липоевая кислота и бенфотиамин). Рассмотрено применение витаминов группы В для лечения ДПН. Проведен поиск соответствующих источников в информационных базах PubMed и Scopus, включавший временной период до 12.04.2024. Опыт применения витаминов группы В показывает, что максимальная эффективность достигается при использовании их в комплексе, что обусловлено взаимодополняющим действием каждого отдельного витамина. Применение комбинации витаминов В1, В6 и В12 при ДПН нормализует рефлекторные реакции, помогает устранить нарушения чувствительности, повышает скорость проведения по нервным волокнам, оказывает умеренное анальгетическое действие.
Ключевые слова: сахарный диабет, диабетическая полинейропатия, лечение, витамин В1, витамин В6, витамин В12, комплекс витаминов группы В, Комбилипен®
Keywords: diabetes mellitus, diabetic polyneuropathy, treatment, vitamin B1, vitamin B6, vitamin B12, vitamin B complex, Combilipen®
Ключевые слова: сахарный диабет, диабетическая полинейропатия, лечение, витамин В1, витамин В6, витамин В12, комплекс витаминов группы В, Комбилипен®
________________________________________________
Keywords: diabetes mellitus, diabetic polyneuropathy, treatment, vitamin B1, vitamin B6, vitamin B12, vitamin B complex, Combilipen®
Полный текст
Список литературы
1. Дедов И.И., Шестакова М.В., Майоров А.Ю., и др. Алгоритмы специализированной медицинской помощи больным сахарным диабетом. Под ред. И.И. Дедова, М.В. Шестаковой, А.Ю. Майорова. Вып. 11. Сахарный диабет. 2023;26(2S):1-157 [Dedov II, Shestakova MV, Mayorov AIu, et al. Standards of Specialized Diabetes Care. Ed. by I.I. Dedov, M.V. Shestakova, A.Yu. Mayorov. 11th Edition. Diabetes Mellitus. 2023;26(2S):1-157 (in Russian)]. DOI:10.14341/DM13042
2. Шестакова Е.А., Лунина Е.Ю., Галстян Г.Р., и др. Распространенность нарушений углеводного обмена у лиц с различными сочетаниями факторов риска сахарного диабета 2 типа в когорте пациентов исследования NATION. Сахарный диабет. 2020;23(1):4-11 [Shestakova EA, Lunina EY, Galstyan GR, et al. Type 2 diabetes and prediabetes prevalence in patients with different risk factor combinations in the NATION study. Diabetes Mellitus. 2020;23(1):4-11 (in Russian)]. DOI:10.14341/DM12286
3. International Diabetes Federation. IDF Diabetes Atlas, 9th ed. Brussels, Belgium, 2019. Available at: https://www.diabetesatlas.org. Accessed: 12.12.2023.
4. Jensen TS, Karlsson P, Gylfadottir SS, et al. Painful and non-painful diabetic neuropathy, diagnostic challenges and implications for future management. Brain.
2021;144(6):1632-45. DOI:10.1093/brain/awab079
5. Ang L, Mizokami-Stout K, Eid SA, et al. The conundrum of diabetic neuropathies – Past, present, and future. J Diabetes Complications. 2022;36(11):108334. DOI:10.1016/j.jdiacomp.2022.108334
6. Сахарный диабет 2-го типа у взрослых. Клинические рекомендации. 2022. Режим доступа: https://cr.minzdrav.gov.ru/recomend/290_2. Ссылка активна на 10.04.2024 [Sakharnyi diabet 2-go tipa u vzroslykh. Klinicheskie rekomendatsii. 2022. Available at: https://cr.minzdrav.gov.ru/recomend/290_2. Accessed: 12.12.2023 (in Russian)].
7. Сахарный диабет 1-го типа у взрослых. Клинические рекомендации. 2022. Режим доступа: https://cr.minzdrav.gov.ru/recomend/286_2. Ссылка активна на 10.04.2024 [Sakharnyi diabet 1-go tipa u vzroslykh. Klinicheskie rekomendatsii. 2022. Available at: https://cr.minzdrav.gov.ru/recomend/286_2. Accessed: 12.12.2023 (in Russian)].
8. American Diabetes Association Professional Practice Committee. 12. Retinopathy, Neuropathy, and Foot Care: Standards of Medical Care in Diabetes-2022. Diabetes Care. 2022;45(Suppl. 1):S185-94. DOI:10.2337/dc22-S012
9. Hicks CW, Selvin E. Epidemiology of Peripheral Neuropathy and Lower Extremity Disease in Diabetes. Curr Diab Rep. 2019;19(10):86. DOI:10.1007/s11892-019-1212-8
10. Anastasi JK, Capili B. Detecting Peripheral Neuropathy in Patients with Diabetes, Prediabetes and other High-Risk Conditions: An Advanced Practice Nurse’s Perspective. J Med Clin Nurs. 2022;3(2). DOI:10.47363/jmcn/2022(3)143
11. Elafros MA, Andersen H, Bennett DL, et al. Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments. Lancet Neurol. 2022;21(10):922-36. DOI:10.1016/S1474-4422(22)00188-0
12. Quiroz-Aldave J, Durand-Vásquez M, Gamarra-Osorio E, et al. Diabetic neuropathy: Past, present, and future. Caspian J Intern Med. 2023;14(2):153-69. DOI:10.22088/cjim.14.2.153
13. Fan Q, Gordon Smith A. Recent updates in the treatment of diabetic polyneuropathy. Fac Rev. 2022;11:30. DOI:10.12703/r/11-30
14. Ziegler D, Tesfaye S, Spallone V, et al. Screening, diagnosis and management of diabetic sensorimotor polyneuropathy in clinical practice: International expert consensus recommendations. Diabetes Res Clin Pract. 2022;186:109063. DOI:10.1016/j.diabres.2021.109063
15. Ziegler D, Papanas N, Schnell O, et al. Current concepts in the management of diabetic polyneuropathy. J Diabetes Investig. 2021;12(4):464-75. DOI:10.1111/jdi.13401
16. Ziegler D. Pathogenetic treatments for diabetic peripheral neuropathy. Diabetes Res Clin Pract. 2023;206(Suppl. 1):110764. DOI:10.1016/j.diabres.2023.110764
17. Bondar A, Popa AR, Papanas N, et al. Diabetic neuropathy: A narrative review of risk factors, classification, screening and current pathogenic treatment options (Review). Exp Ther Med. 2021;22(1):690. DOI:10.3892/etm.2021.10122
18. Winkler G, Kempler P. Pathomechanism of diabetic neuropathy: background of the pathogenesis-oriented therapy. Orv Hetil. 2010;151(24):971-81. DOI:10.1556/OH.2010.28898
19. Várkonyi T, Körei A, Putz Z, et al. Advances in the management of diabetic neuropathy. Minerva Med. 2017;108(5):419-37. DOI:10.23736/S0026-4806.17.05257-0
20. Mrowicka M, Mrowicki J, Dragan G, Majsterek I. The importance of thiamine (vitamin B1) in humans. Biosci Rep. 2023;43(10). DOI:10.1042/BSR20230374
21. Bozic I, Lavrnja I. Thiamine and benfotiamine: Focus on their therapeutic potential. Heliyon. 2023;9(11):e21839. DOI:10.1016/j.heliyon.2023.e21839
22. Nardone R, Höller Y, Storti M, et al. Thiamine deficiency induced neurochemical, neuroanatomical, and neuropsychological alterations: a reappraisal. ScientificWorldJournal. 2013;2013:309143. DOI:10.1155/2013/309143
23. Beltramo E, Mazzeo A, Porta M. Thiamine and diabetes: back to the future? Acta Diabetol. 2021;58(11):1433-9. DOI:10.1007/s00592-021-01752-4
24. Thornalley PJ. The potential role of thiamine (vitamin B1) in diabetic complications. Curr Diabetes Rev. 2005;1(3):287-98. DOI:10.2174/157339905774574383
25. Obrenovich ME, Monnier VM. Vitamin B1 blocks damage caused by hyperglycemia. Sci Aging Knowledge Environ. 2003;2003(10):PE6. DOI:10.1126/sageke.2003.10.pe6
26. Page GL, Laight D, Cummings MH. Thiamine deficiency in diabetes mellitus and the impact of thiamine replacement on glucose metabolism and vascular disease. Int J Clin Pract. 2011;65(6):684-90. DOI:10.1111/j.1742-1241.2011.02680.x
27. Pácal L, Kuricová K, Kaňková K. Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation? World J Diabetes. 2014;5(3):288-95. DOI:10.4239/wjd.v5.i3.288
28. Khan MU, Mubeen M, Chohan HK, et al. Correlation of Fasting Blood Sugar and Glycated Hemoglobin (HbA1c) With Thiamine Levels in Diabetic Patients. Cureus. 2023;15(9):e46178. DOI:10.7759/cureus.46178
29. Dakshinamurti K. Vitamins and their derivatives in the prevention and treatment of metabolic syndrome diseases (diabetes). Can J Physiol Pharmacol.
2015;93(5):355-62. DOI:10.1139/cjpp-2014-0479
30. Balakumar P, Rohilla A, Krishan P, et al. The multifaceted therapeutic potential of benfotiamine. Pharmacol Res. 2010;61(6):482-8. DOI:10.1016/j.phrs.2010.02.008
31. Raj V, Ojha S, Howarth FC, et al. Therapeutic potential of benfotiamine and its molecular targets. Eur Rev Med Pharmacol Sci. 2018;22(10):3261-73. DOI:10.26355/eurrev_201805_15089
32. Sambon M, Wins P, Bettendorff L. Neuroprotective Effects of Thiamine and Precursors with Higher Bioavailability: Focus on Benfotiamine and Dibenzoylthiamine. Int J Mol Sci. 2021;22(11). DOI:10.3390/ijms22115418
33. Bettendorff L. Synthetic Thioesters of Thiamine: Promising Tools for Slowing Progression of Neurodegenerative Diseases. Int J Mol Sci. 2023;24(14). DOI:10.3390/ijms241411296
34. Nikolić A, Kacar A, Lavrnić D, et al. [The effect of benfothiamine in the therapy of diabetic polyneuropathy]. Srp Arh Celok Lek. 2009;137(11-12):594-600 (in Serbian). DOI:10.2298/sarh0912594n
35. Abosamak NR, Gupta V. Vitamin B6 (Pyridoxine). In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2024.
36. Tein I. Recent advances in neurometabolic diseases: The genetic role in the modern era. Epilepsy Behav. 2023;145:109338. DOI:10.1016/j.yebeh.2023.109338
37. Abbas ZG, Swai AB. Evaluation of the efficacy of thiamine and pyridoxine in the treatment of symptomatic diabetic peripheral neuropathy. East Afr Med J. 1997;74(12):803-8.
38. Eckert M, Schejbal P. Therapy of neuropathies with a vitamin B combination. Symptomatic treatment of painful diseases of the peripheral nervous system with a combination preparation of thiamine, pyridoxine and cyanocobalamin. Fortschr Med. 1992;110(29):544-8.
39. Stracke H, Lindemann A, Federlin K. A benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy. Exp Clin Endocrinol Diabetes. 1996;104(4):311-6.
DOI:10.1055/s-0029-1211460
40. Guilland JC, Aimone-Gastin I. [Vitamin B12 (cobalamin)]. Rev Prat. 2013;63(8):1085-7, 1089-90 (in French).
41. Tanaka H. Old or new medicine? Vitamin B12 and peripheral nerve neuropathy. Brain Nerve. 2013;65(9):1077-82.
42. França DS, Souza AL, Almeida KR, et al. B vitamins induce an antinociceptive effect in the acetic acid and formaldehyde models of nociception in mice. Eur J Pharmacol. 2001;421(3):157-64. DOI:10.1016/s0014-2999(01)01038-x
43. Schleicher E, Didangelos T, Kotzakioulafi E, et al. Clinical Pathobiochemistry of Vitamin B(12) Deficiency: Improving Our Understanding by Exploring Novel Mechanisms with a Focus on Diabetic Neuropathy. Nutrients. 2023;15(11). DOI:10.3390/nu15112597
44. Didangelos T, Karlafti E, Kotzakioulafi E, et al. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2021;13(2). DOI:10.3390/nu13020395
45. Jin HY, Lee KA, Kim YJ, et al. Bidirectional association between diabetic peripheral neuropathy and vitamin B12 deficiency: Two longitudinal 9-year follow-up studies using a national sample cohort. Prim Care Diabetes. 2023;17(5):436-43. DOI:10.1016/j.pcd.2023.06.006
46. Sun Y, Lai MS, Lu CJ. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwan. 2005;14(2):48-54.
47. Xu Q, Pan J, Yu J, et al. Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy. Diabetes Res Clin Pract. 2013;101(2):99-105. DOI:10.1016/j.diabres.2013.03.033
48. Sawangjit R, Thongphui S, Chaichompu W, Phumart P. Efficacy and Safety of Mecobalamin on Peripheral Neuropathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Altern Complement Med. 2020;26(12):1117-29. DOI:10.1089/acm.2020.0068
49. Аметов А.С., Солуянова Т.Н. Роль витаминов группы B в лечении диабетической полинейропатии. Медицинский совет. 2010;7:18-20 [Ametov AS, Soluyanova TN. The role of B vitamins in the treatment of diabetic polyneuropathy. Medical Counsil. 2010;7:18-20 (in Russian)].
50. Vrolijk MF, Opperhuizen A, Jansen EHJM, et al. The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. Toxicol In Vitro. 2017;44:206-12. DOI:10.1016/j.tiv.2017.07.009
51. Кукушкин М.Л. Витамины группы В (B1, B6, B12) в комплексной терапии болевых синдромов. Российский журнал боли. 2019;17(3):39-45 [Kukushkin ML. Vitamins of group B (B1, B6, B12) in complex therapy of pain syndromes. Russian Journal of Pain. 2019;17(3):39-45 (in Russian)]. DOI:10.25731/RASP.2019.03.31
52. Скелетно-мышечные (неспецифические) боли в нижней части спины. Клинические рекомендации. 2023. Режим доступа: https://cr.minzdrav.gov.ru/recomend/778_1. Ссылка активна на 10.04.2024 [Skeletno-myshechnye (nespetsificheskie) boli v nizhnei chasti spiny. Klinicheskie rekomendatsii. 2023. Available at: https://cr.minzdrav.gov.ru/recomend/778_1. Accessed: 10.04.2024 (in Russian)].
53. Дискогенная пояснично-крестцовая радикулопатия. Клинические рекомендации. 2023. Режим доступа: https://cr.minzdrav.gov.ru/recomend/777_1. Ссылка активна на 10.04.2024 [Diskogennaia poiasnichno-kresttsovaia radikulopatiia. Klinicheskie rekomendatsii. 2023. Available at: https://cr.minzdrav.gov.ru/recomend/777_1. Accessed: 12.12.2023 (in Russian)].
54. Дубинина И.И., Карапыш Т.В., Носова Н.Ф. Эффективность комплексной терапии дистальной нейропатии у больных сахарным диабетом 2 типа в сочетании с первичным гипотиреозом. Сахарный диабет. 2011;14(3):76-9 [Dubinina II, Karapysh TV, Nosova NF. Efficacy of combined treatment of distal polyneuropathy in patients with type 2 diabetes mellitus and concomitant primaryhypothyroidism. Diabetes Mellitus. 2011;14(3):76-9 (in Russian)]. DOI:10.14341/2072-0351-6228
55. Доскина Е.В. Применение витаминов группы B в патогенетическом лечении диабетической полинейропатии. Эффективная фармакотерапия. 2012;46:30-5 [Doskina EV. Primenenie vitaminov gruppy B v patogeneticheskom lechenii diabeticheskoi polineiropatii. Effective Pharmacotherapy. 2012;46:30-5 (in Russian)].
56. Храмилин В.Н., Андреева В.Л., Демидова И.Ю. Комбинированная терапия болевой диабетической полинейропатии: результаты пилотного исследования. Фарматека. 2014;16:48-53 [Khramilin VN, Andreeva VL, Demidova IIu. Kombinirovannaia terapiia bolevoi diabeticheskoi polineiropatii: rezul’taty pilotnogo issledovaniia. Farmateka. 2014;16:48-53 (in Russian)].
57. Котова О.В. Диабетическая нейропатия. Применение нейротропных витаминов. Поликлиника. 2015;1(2):36-9 [Kotova OV. Diabetic neuropathy. Application of neurotropic vitamins. Polyclinic = Poliklinika. 2015;1(2):36-9 (in Russian)].
58. Дубинина И.И., Берстнева С.В., Баранов В.В., Азимкова Л.В. Эффективность комбинированной терапии диабетической дистальной нейропатии у больных сахарным диабетом 2 типа. Сахарный диабет. 2016;4:315-21 [Dubinina II, Berstneva SV, Baranov VV, Azimkova LV. Efficacy of complex pathogenic therapy of diabetic distal neuropathy in patients with type 2 diabetes mellitus. Diabetes Mellitus. 2016;19(4):315-21 (in Russian)]. DOI:10.14341/DM7637DOI:10.14341/DM7637
59. Штаймец С.В., Ченцова Т.С., Катина М.М., Письменный И.В. Профилактика поздних неврологических и хирургических осложнений сахарного диабета в условиях дневного стационара городской поликлиники. Профилактическая медицина. 2020;5:139-43 [Shtaimets SV, Chencova TS, Katina MM, Pismennyy IV. Prevention of late neurological and surgical complications of diabetes mellitus in the daycare center of the city clinic. Profilakticheskaia meditsina. 2020;5:139-43 (in Russian)]. DOI:10.17116/profmed202023051139
60. Кукес В., Ших Е., Махова В. Отечественные препараты «Apтpозaн®» и «Бенфолипен®»: возможности комбинированной терапии болевого синдрома. Врач. 2009;7:57-60 [Kukes V, Shikh E, Makhova V. Otechestvennye preparaty “Aptpozan®” i “Benfolipen®”: vozmozhnosti kombinirovannoi terapii bolevogo sindroma. Vrach. 2009;7:57-60 (in Russian)].
61. Подлипалин А. Препарат Комбилипен в комбинированной терапии хронической боли в спине. Врач. 2009;8:28-9 [Podlipalin A. Preparat Kombilipen v kombinirovannoi terapii khronicheskoi boli v spine. Vrach. 2009;8:28-9 (in Russian)].
62. Батышева Т.Т., Отческая О.В., Хозова А.А., и др. Эффективность применения комбинации препаратов артрозан и комбилипен у пациентов с острой болью в нижней части спины. Журнал неврологии и психиатрии им. С.С. Корсакова. 2011;9(2):41-4 [Batysheva TT, Otcheskaia OV, Khozova AA, et al. Effektivnost’ primeneniia kombinatsii preparatov artrozan i kombilipen u patsientov s ostroi bol’iu v nizhnei chasti spiny. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2011;9(2):41-4 [(in Russian)].
63. Камчатнов П.Р., Умарова Х.Я., Осмаева З.Х. Применение нестероидных противовоспалительных препаратов и комплекса витаминов группы В у пациентов с поясничной болью. Consilium Medicum. 2014;16(9):70-5 [Kamchatnov PR, Umarova KhIa, Osmaeva ZKh. The use of non-steroidal anti-inflammatory drugs and a complex of B vitamins in patients with lumbar pain. Consilium Medicum. 2014;16(9):70-5 (in Russian)].
64. Умарова Х.Я., Камчатнов П.Р., Осмаева З.Х. Нестероидные противовоспалительные препараты и витамины группы В у пациентов с поясничной болью. РМЖ. Медицинское обозрение. 2015;10:584-8 [Umarova KhIa, Kamchatnov PR, Osmaeva ZKh. Nesteroidnye protivovospalitel’nye preparaty i vitaminy gruppy V u patsientov s poiasnichnoi bol’iu. RMZh. Meditsinskoe obozrenie. 2015;10:584-8 (in Russian)].
65. Исайкин А.И., Черненко О.А., Иванова М.А., Стиценко А.Н. Боль в пояснице, обусловленная патологией межпозвоночных дисков. Consilium Medicum. 2015;17(2): 52-60 [Isaykin AI, Chernenko OA, Ivanova MA, Stitsenko AN. Back pain caused by disorders of the intervertebral discs. Consilium Medicum. 2015;17(2):52-60 (in Russian)].
DOI:10.26442/2075-1753_2015.2.52-60
66. Трухан Д.И., Давыдов Е.Л. Дорсалгия: актуальные аспекты терапии на этапе оказания первичной медико-санитарной помощи. Consilium Medicum. 2015;9:82-7 [Trukhan DI, Davydov EL. Dorsalgia: topical aspects of treatment at stages of primary health care. Consilium Medicum. 2015;7(9):82-7 (in Russian)]. DOI:10.26442/2075-1753_2015.9.82-87
67. Трухан Д.И., Викторова И.А., Трухан Л.Ю. Изменение органов и тканей полости рта при заболеваниях внутренних органов. М.: Практическая медицина, 2012 [Trukhan DI, Viktorova IA, Trukhan LIu. Izmenenie organov i tkanei polosti rta pri zabolevaniiakh vnutrennikh organov. Moscow: Prakticheskaia meditsina, 2012 (in Russian)].
2023;26(2S):1-157 (in Russian). DOI:10.14341/DM13042
2. Shestakova EA, Lunina EY, Galstyan GR, et al. Type 2 diabetes and prediabetes prevalence in patients with different risk factor combinations in the NATION study. Diabetes Mellitus. 2020;23(1):4-11 (in Russian). DOI:10.14341/DM12286
3. International Diabetes Federation. IDF Diabetes Atlas, 9th ed. Brussels, Belgium, 2019. Available at: https://www.diabetesatlas.org. Accessed: 12.12.2023.
4. Jensen TS, Karlsson P, Gylfadottir SS, et al. Painful and non-painful diabetic neuropathy, diagnostic challenges and implications for future management. Brain.
2021;144(6):1632-45. DOI:10.1093/brain/awab079
5. Ang L, Mizokami-Stout K, Eid SA, et al. The conundrum of diabetic neuropathies – Past, present, and future. J Diabetes Complications. 2022;36(11):108334. DOI:10.1016/j.jdiacomp.2022.108334
6. Sakharnyi diabet 2-go tipa u vzroslykh. Klinicheskie rekomendatsii. 2022. Available at: https://cr.minzdrav.gov.ru/recomend/290_2. Accessed: 12.12.2023 (in Russian).
7. Sakharnyi diabet 1-go tipa u vzroslykh. Klinicheskie rekomendatsii. 2022. Available at: https://cr.minzdrav.gov.ru/recomend/286_2. Accessed: 12.12.2023 (in Russian).
8. American Diabetes Association Professional Practice Committee. 12. Retinopathy, Neuropathy, and Foot Care: Standards of Medical Care in Diabetes-2022. Diabetes Care. 2022;45(Suppl. 1):S185-94. DOI:10.2337/dc22-S012
9. Hicks CW, Selvin E. Epidemiology of Peripheral Neuropathy and Lower Extremity Disease in Diabetes. Curr Diab Rep. 2019;19(10):86. DOI:10.1007/s11892-019-1212-8
10. Anastasi JK, Capili B. Detecting Peripheral Neuropathy in Patients with Diabetes, Prediabetes and other High-Risk Conditions: An Advanced Practice Nurse’s Perspective. J Med Clin Nurs. 2022;3(2). DOI:10.47363/jmcn/2022(3)143
11. Elafros MA, Andersen H, Bennett DL, et al. Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments. Lancet Neurol. 2022;21(10):922-36. DOI:10.1016/S1474-4422(22)00188-0
12. Quiroz-Aldave J, Durand-Vásquez M, Gamarra-Osorio E, et al. Diabetic neuropathy: Past, present, and future. Caspian J Intern Med. 2023;14(2):153-69. DOI:10.22088/cjim.14.2.153
13. Fan Q, Gordon Smith A. Recent updates in the treatment of diabetic polyneuropathy. Fac Rev. 2022;11:30. DOI:10.12703/r/11-30
14. Ziegler D, Tesfaye S, Spallone V, et al. Screening, diagnosis and management of diabetic sensorimotor polyneuropathy in clinical practice: International expert consensus recommendations. Diabetes Res Clin Pract. 2022;186:109063. DOI:10.1016/j.diabres.2021.109063
15. Ziegler D, Papanas N, Schnell O, et al. Current concepts in the management of diabetic polyneuropathy. J Diabetes Investig. 2021;12(4):464-75. DOI:10.1111/jdi.13401
16. Ziegler D. Pathogenetic treatments for diabetic peripheral neuropathy. Diabetes Res Clin Pract. 2023;206(Suppl. 1):110764. DOI:10.1016/j.diabres.2023.110764
17. Bondar A, Popa AR, Papanas N, et al. Diabetic neuropathy: A narrative review of risk factors, classification, screening and current pathogenic treatment options (Review). Exp Ther Med. 2021;22(1):690. DOI:10.3892/etm.2021.10122
18. Winkler G, Kempler P. Pathomechanism of diabetic neuropathy: background of the pathogenesis-oriented therapy. Orv Hetil. 2010;151(24):971-81. DOI:10.1556/OH.2010.28898
19. Várkonyi T, Körei A, Putz Z, et al. Advances in the management of diabetic neuropathy. Minerva Med. 2017;108(5):419-37. DOI:10.23736/S0026-4806.17.05257-0
20. Mrowicka M, Mrowicki J, Dragan G, Majsterek I. The importance of thiamine (vitamin B1) in humans. Biosci Rep. 2023;43(10). DOI:10.1042/BSR20230374
21. Bozic I, Lavrnja I. Thiamine and benfotiamine: Focus on their therapeutic potential. Heliyon. 2023;9(11):e21839. DOI:10.1016/j.heliyon.2023.e21839
22. Nardone R, Höller Y, Storti M, et al. Thiamine deficiency induced neurochemical, neuroanatomical, and neuropsychological alterations: a reappraisal. ScientificWorldJournal. 2013;2013:309143. DOI:10.1155/2013/309143
23. Beltramo E, Mazzeo A, Porta M. Thiamine and diabetes: back to the future? Acta Diabetol. 2021;58(11):1433-9. DOI:10.1007/s00592-021-01752-4
24. Thornalley PJ. The potential role of thiamine (vitamin B1) in diabetic complications. Curr Diabetes Rev. 2005;1(3):287-98. DOI:10.2174/157339905774574383
25. Obrenovich ME, Monnier VM. Vitamin B1 blocks damage caused by hyperglycemia. Sci Aging Knowledge Environ. 2003;2003(10):PE6. DOI:10.1126/sageke.2003.10.pe6
26. Page GL, Laight D, Cummings MH. Thiamine deficiency in diabetes mellitus and the impact of thiamine replacement on glucose metabolism and vascular disease. Int J Clin Pract. 2011;65(6):684-90. DOI:10.1111/j.1742-1241.2011.02680.x
27. Pácal L, Kuricová K, Kaňková K. Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation? World J Diabetes. 2014;5(3):288-95. DOI:10.4239/wjd.v5.i3.288
28. Khan MU, Mubeen M, Chohan HK, et al. Correlation of Fasting Blood Sugar and Glycated Hemoglobin (HbA1c) With Thiamine Levels in Diabetic Patients. Cureus. 2023;15(9):e46178. DOI:10.7759/cureus.46178
29. Dakshinamurti K. Vitamins and their derivatives in the prevention and treatment of metabolic syndrome diseases (diabetes). Can J Physiol Pharmacol.
2015;93(5):355-62. DOI:10.1139/cjpp-2014-0479
30. Balakumar P, Rohilla A, Krishan P, et al. The multifaceted therapeutic potential of benfotiamine. Pharmacol Res. 2010;61(6):482-8. DOI:10.1016/j.phrs.2010.02.008
31. Raj V, Ojha S, Howarth FC, et al. Therapeutic potential of benfotiamine and its molecular targets. Eur Rev Med Pharmacol Sci. 2018;22(10):3261-73. DOI:10.26355/eurrev_201805_15089
32. Sambon M, Wins P, Bettendorff L. Neuroprotective Effects of Thiamine and Precursors with Higher Bioavailability: Focus on Benfotiamine and Dibenzoylthiamine. Int J Mol Sci. 2021;22(11). DOI:10.3390/ijms22115418
33. Bettendorff L. Synthetic Thioesters of Thiamine: Promising Tools for Slowing Progression of Neurodegenerative Diseases. Int J Mol Sci. 2023;24(14). DOI:10.3390/ijms241411296
34. Nikolić A, Kacar A, Lavrnić D, et al. [The effect of benfothiamine in the therapy of diabetic polyneuropathy]. Srp Arh Celok Lek. 2009;137(11-12):594-600 (in Serbian). DOI:10.2298/sarh0912594n
35. Abosamak NR, Gupta V. Vitamin B6 (Pyridoxine). In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2024.
36. Tein I. Recent advances in neurometabolic diseases: The genetic role in the modern era. Epilepsy Behav. 2023;145:109338. DOI:10.1016/j.yebeh.2023.109338
37. Abbas ZG, Swai AB. Evaluation of the efficacy of thiamine and pyridoxine in the treatment of symptomatic diabetic peripheral neuropathy. East Afr Med J. 1997;74(12):803-8.
38. Eckert M, Schejbal P. Therapy of neuropathies with a vitamin B combination. Symptomatic treatment of painful diseases of the peripheral nervous system with a combination preparation of thiamine, pyridoxine and cyanocobalamin. Fortschr Med. 1992;110(29):544-8.
39. Stracke H, Lindemann A, Federlin K. A benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy. Exp Clin Endocrinol Diabetes. 1996;104(4):311-6.
DOI:10.1055/s-0029-1211460
40. Guilland JC, Aimone-Gastin I. [Vitamin B12 (cobalamin)]. Rev Prat. 2013;63(8):1085-7, 1089-90 (in French).
41. Tanaka H. Old or new medicine? Vitamin B12 and peripheral nerve neuropathy. Brain Nerve. 2013;65(9):1077-82.
42. França DS, Souza AL, Almeida KR, et al. B vitamins induce an antinociceptive effect in the acetic acid and formaldehyde models of nociception in mice. Eur J Pharmacol. 2001;421(3):157-64. DOI:10.1016/s0014-2999(01)01038-x
43. Schleicher E, Didangelos T, Kotzakioulafi E, et al. Clinical Pathobiochemistry of Vitamin B(12) Deficiency: Improving Our Understanding by Exploring Novel Mechanisms with a Focus on Diabetic Neuropathy. Nutrients. 2023;15(11). DOI:10.3390/nu15112597
44. Didangelos T, Karlafti E, Kotzakioulafi E, et al. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2021;13(2). DOI:10.3390/nu13020395
45. Jin HY, Lee KA, Kim YJ, et al. Bidirectional association between diabetic peripheral neuropathy and vitamin B12 deficiency: Two longitudinal 9-year follow-up studies using a national sample cohort. Prim Care Diabetes. 2023;17(5):436-43. DOI:10.1016/j.pcd.2023.06.006
46. Sun Y, Lai MS, Lu CJ. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwan. 2005;14(2):48-54.
47. Xu Q, Pan J, Yu J, et al. Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy. Diabetes Res Clin Pract. 2013;101(2):99-105. DOI:10.1016/j.diabres.2013.03.033
48. Sawangjit R, Thongphui S, Chaichompu W, Phumart P. Efficacy and Safety of Mecobalamin on Peripheral Neuropathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Altern Complement Med. 2020;26(12):1117-29. DOI:10.1089/acm.2020.0068
49. Ametov AS, Soluyanova TN. The role of B vitamins in the treatment of diabetic polyneuropathy. Medical Counsil. 2010;7:18-20 (in Russian).
50. Vrolijk MF, Opperhuizen A, Jansen EHJM, et al. The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. Toxicol In Vitro. 2017;44:206-12. DOI:10.1016/j.tiv.2017.07.009
51. Kukushkin ML. Vitamins of group B (B1, B6, B12) in complex therapy of pain syndromes. Russian Journal of Pain. 2019;17(3):39-45 (in Russian). DOI:10.25731/RASP.2019.03.31
52. Skeletno-myshechnye (nespetsificheskie) boli v nizhnei chasti spiny. Klinicheskie rekomendatsii. 2023. Available at: https://cr.minzdrav.gov.ru/recomend/778_1. Accessed: 10.04.2024 (in Russian).
53. Diskogennaia poiasnichno-kresttsovaia radikulopatiia. Klinicheskie rekomendatsii. 2023. Available at: https://cr.minzdrav.gov.ru/recomend/777_1. Accessed: 12.12.2023 (in Russian).
54. Dubinina II, Karapysh TV, Nosova NF. Efficacy of combined treatment of distal polyneuropathy in patients with type 2 diabetes mellitus and concomitant primaryhypothyroidism. Diabetes Mellitus. 2011;14(3):76-9 (in Russian). DOI:10.14341/2072-0351-6228
55. Doskina EV. Primenenie vitaminov gruppy B v patogeneticheskom lechenii diabeticheskoi polineiropatii. Effective Pharmacotherapy. 2012;46:30-5 (in Russian).
56. Khramilin VN, Andreeva VL, Demidova IIu. Kombinirovannaia terapiia bolevoi diabeticheskoi polineiropatii: rezul’taty pilotnogo issledovaniia. Farmateka. 2014;16:48-53 (in Russian).
57. Kotova OV. Diabetic neuropathy. Application of neurotropic vitamins. Polyclinic = Poliklinika. 2015;1(2):36-9 (in Russian).
58. Dubinina II, Berstneva SV, Baranov VV, Azimkova LV. Efficacy of complex pathogenic therapy of diabetic distal neuropathy in patients with type 2 diabetes mellitus. Diabetes Mellitus. 2016;19(4):315-21 (in Russian). DOI:10.14341/DM7637DOI:10.14341/DM7637
59. Shtaimets SV, Chencova TS, Katina MM, Pismennyy IV. Prevention of late neurological and surgical complications of diabetes mellitus in the daycare center of the city clinic. Profilakticheskaia meditsina. 2020;5:139-43 (in Russian). DOI:10.17116/profmed202023051139
60. Kukes V, Shikh E, Makhova V. Otechestvennye preparaty “Aptpozan®” i “Benfolipen®”: vozmozhnosti kombinirovannoi terapii bolevogo sindroma. Vrach. 2009;7:57-60 (in Russian).
61. Podlipalin A. Preparat Kombilipen v kombinirovannoi terapii khronicheskoi boli v spine. Vrach. 2009;8:28-9 (in Russian).
62. Batysheva TT, Otcheskaia OV, Khozova AA, et al. Effektivnost’ primeneniia kombinatsii preparatov artrozan i kombilipen u patsientov s ostroi bol’iu v nizhnei chasti spiny. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2011;9(2):41-4 [(in Russian).
63. Kamchatnov PR, Umarova KhIa, Osmaeva ZKh. The use of non-steroidal anti-inflammatory drugs and a complex of B vitamins in patients with lumbar pain. Consilium Medicum. 2014;16(9):70-5 (in Russian).
64. Umarova KhIa, Kamchatnov PR, Osmaeva ZKh. Nesteroidnye protivovospalitel’nye preparaty i vitaminy gruppy V u patsientov s poiasnichnoi bol’iu. RMZh. Meditsinskoe obozrenie. 2015;10:584-8 (in Russian).
65. Isaykin AI, Chernenko OA, Ivanova MA, Stitsenko AN. Back pain caused by disorders of the intervertebral discs. Consilium Medicum. 2015;17(2):52-60 (in Russian). DOI:10.26442/2075-1753_2015.2.52-60
66. Trukhan DI, Davydov EL. Dorsalgia: topical aspects of treatment at stages of primary health care. Consilium Medicum. 2015;7(9):82-7 (in Russian).
DOI:10.26442/2075-1753_2015.9.82-87
67. Trukhan DI, Viktorova IA, Trukhan LIu. Izmenenie organov i tkanei polosti rta pri zabolevaniiakh vnutrennikh organov. Moscow: Prakticheskaia meditsina, 2012 (in Russian).
2. Шестакова Е.А., Лунина Е.Ю., Галстян Г.Р., и др. Распространенность нарушений углеводного обмена у лиц с различными сочетаниями факторов риска сахарного диабета 2 типа в когорте пациентов исследования NATION. Сахарный диабет. 2020;23(1):4-11 [Shestakova EA, Lunina EY, Galstyan GR, et al. Type 2 diabetes and prediabetes prevalence in patients with different risk factor combinations in the NATION study. Diabetes Mellitus. 2020;23(1):4-11 (in Russian)]. DOI:10.14341/DM12286
3. International Diabetes Federation. IDF Diabetes Atlas, 9th ed. Brussels, Belgium, 2019. Available at: https://www.diabetesatlas.org. Accessed: 12.12.2023.
4. Jensen TS, Karlsson P, Gylfadottir SS, et al. Painful and non-painful diabetic neuropathy, diagnostic challenges and implications for future management. Brain.
2021;144(6):1632-45. DOI:10.1093/brain/awab079
5. Ang L, Mizokami-Stout K, Eid SA, et al. The conundrum of diabetic neuropathies – Past, present, and future. J Diabetes Complications. 2022;36(11):108334. DOI:10.1016/j.jdiacomp.2022.108334
6. Сахарный диабет 2-го типа у взрослых. Клинические рекомендации. 2022. Режим доступа: https://cr.minzdrav.gov.ru/recomend/290_2. Ссылка активна на 10.04.2024 [Sakharnyi diabet 2-go tipa u vzroslykh. Klinicheskie rekomendatsii. 2022. Available at: https://cr.minzdrav.gov.ru/recomend/290_2. Accessed: 12.12.2023 (in Russian)].
7. Сахарный диабет 1-го типа у взрослых. Клинические рекомендации. 2022. Режим доступа: https://cr.minzdrav.gov.ru/recomend/286_2. Ссылка активна на 10.04.2024 [Sakharnyi diabet 1-go tipa u vzroslykh. Klinicheskie rekomendatsii. 2022. Available at: https://cr.minzdrav.gov.ru/recomend/286_2. Accessed: 12.12.2023 (in Russian)].
8. American Diabetes Association Professional Practice Committee. 12. Retinopathy, Neuropathy, and Foot Care: Standards of Medical Care in Diabetes-2022. Diabetes Care. 2022;45(Suppl. 1):S185-94. DOI:10.2337/dc22-S012
9. Hicks CW, Selvin E. Epidemiology of Peripheral Neuropathy and Lower Extremity Disease in Diabetes. Curr Diab Rep. 2019;19(10):86. DOI:10.1007/s11892-019-1212-8
10. Anastasi JK, Capili B. Detecting Peripheral Neuropathy in Patients with Diabetes, Prediabetes and other High-Risk Conditions: An Advanced Practice Nurse’s Perspective. J Med Clin Nurs. 2022;3(2). DOI:10.47363/jmcn/2022(3)143
11. Elafros MA, Andersen H, Bennett DL, et al. Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments. Lancet Neurol. 2022;21(10):922-36. DOI:10.1016/S1474-4422(22)00188-0
12. Quiroz-Aldave J, Durand-Vásquez M, Gamarra-Osorio E, et al. Diabetic neuropathy: Past, present, and future. Caspian J Intern Med. 2023;14(2):153-69. DOI:10.22088/cjim.14.2.153
13. Fan Q, Gordon Smith A. Recent updates in the treatment of diabetic polyneuropathy. Fac Rev. 2022;11:30. DOI:10.12703/r/11-30
14. Ziegler D, Tesfaye S, Spallone V, et al. Screening, diagnosis and management of diabetic sensorimotor polyneuropathy in clinical practice: International expert consensus recommendations. Diabetes Res Clin Pract. 2022;186:109063. DOI:10.1016/j.diabres.2021.109063
15. Ziegler D, Papanas N, Schnell O, et al. Current concepts in the management of diabetic polyneuropathy. J Diabetes Investig. 2021;12(4):464-75. DOI:10.1111/jdi.13401
16. Ziegler D. Pathogenetic treatments for diabetic peripheral neuropathy. Diabetes Res Clin Pract. 2023;206(Suppl. 1):110764. DOI:10.1016/j.diabres.2023.110764
17. Bondar A, Popa AR, Papanas N, et al. Diabetic neuropathy: A narrative review of risk factors, classification, screening and current pathogenic treatment options (Review). Exp Ther Med. 2021;22(1):690. DOI:10.3892/etm.2021.10122
18. Winkler G, Kempler P. Pathomechanism of diabetic neuropathy: background of the pathogenesis-oriented therapy. Orv Hetil. 2010;151(24):971-81. DOI:10.1556/OH.2010.28898
19. Várkonyi T, Körei A, Putz Z, et al. Advances in the management of diabetic neuropathy. Minerva Med. 2017;108(5):419-37. DOI:10.23736/S0026-4806.17.05257-0
20. Mrowicka M, Mrowicki J, Dragan G, Majsterek I. The importance of thiamine (vitamin B1) in humans. Biosci Rep. 2023;43(10). DOI:10.1042/BSR20230374
21. Bozic I, Lavrnja I. Thiamine and benfotiamine: Focus on their therapeutic potential. Heliyon. 2023;9(11):e21839. DOI:10.1016/j.heliyon.2023.e21839
22. Nardone R, Höller Y, Storti M, et al. Thiamine deficiency induced neurochemical, neuroanatomical, and neuropsychological alterations: a reappraisal. ScientificWorldJournal. 2013;2013:309143. DOI:10.1155/2013/309143
23. Beltramo E, Mazzeo A, Porta M. Thiamine and diabetes: back to the future? Acta Diabetol. 2021;58(11):1433-9. DOI:10.1007/s00592-021-01752-4
24. Thornalley PJ. The potential role of thiamine (vitamin B1) in diabetic complications. Curr Diabetes Rev. 2005;1(3):287-98. DOI:10.2174/157339905774574383
25. Obrenovich ME, Monnier VM. Vitamin B1 blocks damage caused by hyperglycemia. Sci Aging Knowledge Environ. 2003;2003(10):PE6. DOI:10.1126/sageke.2003.10.pe6
26. Page GL, Laight D, Cummings MH. Thiamine deficiency in diabetes mellitus and the impact of thiamine replacement on glucose metabolism and vascular disease. Int J Clin Pract. 2011;65(6):684-90. DOI:10.1111/j.1742-1241.2011.02680.x
27. Pácal L, Kuricová K, Kaňková K. Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation? World J Diabetes. 2014;5(3):288-95. DOI:10.4239/wjd.v5.i3.288
28. Khan MU, Mubeen M, Chohan HK, et al. Correlation of Fasting Blood Sugar and Glycated Hemoglobin (HbA1c) With Thiamine Levels in Diabetic Patients. Cureus. 2023;15(9):e46178. DOI:10.7759/cureus.46178
29. Dakshinamurti K. Vitamins and their derivatives in the prevention and treatment of metabolic syndrome diseases (diabetes). Can J Physiol Pharmacol.
2015;93(5):355-62. DOI:10.1139/cjpp-2014-0479
30. Balakumar P, Rohilla A, Krishan P, et al. The multifaceted therapeutic potential of benfotiamine. Pharmacol Res. 2010;61(6):482-8. DOI:10.1016/j.phrs.2010.02.008
31. Raj V, Ojha S, Howarth FC, et al. Therapeutic potential of benfotiamine and its molecular targets. Eur Rev Med Pharmacol Sci. 2018;22(10):3261-73. DOI:10.26355/eurrev_201805_15089
32. Sambon M, Wins P, Bettendorff L. Neuroprotective Effects of Thiamine and Precursors with Higher Bioavailability: Focus on Benfotiamine and Dibenzoylthiamine. Int J Mol Sci. 2021;22(11). DOI:10.3390/ijms22115418
33. Bettendorff L. Synthetic Thioesters of Thiamine: Promising Tools for Slowing Progression of Neurodegenerative Diseases. Int J Mol Sci. 2023;24(14). DOI:10.3390/ijms241411296
34. Nikolić A, Kacar A, Lavrnić D, et al. [The effect of benfothiamine in the therapy of diabetic polyneuropathy]. Srp Arh Celok Lek. 2009;137(11-12):594-600 (in Serbian). DOI:10.2298/sarh0912594n
35. Abosamak NR, Gupta V. Vitamin B6 (Pyridoxine). In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2024.
36. Tein I. Recent advances in neurometabolic diseases: The genetic role in the modern era. Epilepsy Behav. 2023;145:109338. DOI:10.1016/j.yebeh.2023.109338
37. Abbas ZG, Swai AB. Evaluation of the efficacy of thiamine and pyridoxine in the treatment of symptomatic diabetic peripheral neuropathy. East Afr Med J. 1997;74(12):803-8.
38. Eckert M, Schejbal P. Therapy of neuropathies with a vitamin B combination. Symptomatic treatment of painful diseases of the peripheral nervous system with a combination preparation of thiamine, pyridoxine and cyanocobalamin. Fortschr Med. 1992;110(29):544-8.
39. Stracke H, Lindemann A, Federlin K. A benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy. Exp Clin Endocrinol Diabetes. 1996;104(4):311-6.
DOI:10.1055/s-0029-1211460
40. Guilland JC, Aimone-Gastin I. [Vitamin B12 (cobalamin)]. Rev Prat. 2013;63(8):1085-7, 1089-90 (in French).
41. Tanaka H. Old or new medicine? Vitamin B12 and peripheral nerve neuropathy. Brain Nerve. 2013;65(9):1077-82.
42. França DS, Souza AL, Almeida KR, et al. B vitamins induce an antinociceptive effect in the acetic acid and formaldehyde models of nociception in mice. Eur J Pharmacol. 2001;421(3):157-64. DOI:10.1016/s0014-2999(01)01038-x
43. Schleicher E, Didangelos T, Kotzakioulafi E, et al. Clinical Pathobiochemistry of Vitamin B(12) Deficiency: Improving Our Understanding by Exploring Novel Mechanisms with a Focus on Diabetic Neuropathy. Nutrients. 2023;15(11). DOI:10.3390/nu15112597
44. Didangelos T, Karlafti E, Kotzakioulafi E, et al. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2021;13(2). DOI:10.3390/nu13020395
45. Jin HY, Lee KA, Kim YJ, et al. Bidirectional association between diabetic peripheral neuropathy and vitamin B12 deficiency: Two longitudinal 9-year follow-up studies using a national sample cohort. Prim Care Diabetes. 2023;17(5):436-43. DOI:10.1016/j.pcd.2023.06.006
46. Sun Y, Lai MS, Lu CJ. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwan. 2005;14(2):48-54.
47. Xu Q, Pan J, Yu J, et al. Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy. Diabetes Res Clin Pract. 2013;101(2):99-105. DOI:10.1016/j.diabres.2013.03.033
48. Sawangjit R, Thongphui S, Chaichompu W, Phumart P. Efficacy and Safety of Mecobalamin on Peripheral Neuropathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Altern Complement Med. 2020;26(12):1117-29. DOI:10.1089/acm.2020.0068
49. Аметов А.С., Солуянова Т.Н. Роль витаминов группы B в лечении диабетической полинейропатии. Медицинский совет. 2010;7:18-20 [Ametov AS, Soluyanova TN. The role of B vitamins in the treatment of diabetic polyneuropathy. Medical Counsil. 2010;7:18-20 (in Russian)].
50. Vrolijk MF, Opperhuizen A, Jansen EHJM, et al. The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. Toxicol In Vitro. 2017;44:206-12. DOI:10.1016/j.tiv.2017.07.009
51. Кукушкин М.Л. Витамины группы В (B1, B6, B12) в комплексной терапии болевых синдромов. Российский журнал боли. 2019;17(3):39-45 [Kukushkin ML. Vitamins of group B (B1, B6, B12) in complex therapy of pain syndromes. Russian Journal of Pain. 2019;17(3):39-45 (in Russian)]. DOI:10.25731/RASP.2019.03.31
52. Скелетно-мышечные (неспецифические) боли в нижней части спины. Клинические рекомендации. 2023. Режим доступа: https://cr.minzdrav.gov.ru/recomend/778_1. Ссылка активна на 10.04.2024 [Skeletno-myshechnye (nespetsificheskie) boli v nizhnei chasti spiny. Klinicheskie rekomendatsii. 2023. Available at: https://cr.minzdrav.gov.ru/recomend/778_1. Accessed: 10.04.2024 (in Russian)].
53. Дискогенная пояснично-крестцовая радикулопатия. Клинические рекомендации. 2023. Режим доступа: https://cr.minzdrav.gov.ru/recomend/777_1. Ссылка активна на 10.04.2024 [Diskogennaia poiasnichno-kresttsovaia radikulopatiia. Klinicheskie rekomendatsii. 2023. Available at: https://cr.minzdrav.gov.ru/recomend/777_1. Accessed: 12.12.2023 (in Russian)].
54. Дубинина И.И., Карапыш Т.В., Носова Н.Ф. Эффективность комплексной терапии дистальной нейропатии у больных сахарным диабетом 2 типа в сочетании с первичным гипотиреозом. Сахарный диабет. 2011;14(3):76-9 [Dubinina II, Karapysh TV, Nosova NF. Efficacy of combined treatment of distal polyneuropathy in patients with type 2 diabetes mellitus and concomitant primaryhypothyroidism. Diabetes Mellitus. 2011;14(3):76-9 (in Russian)]. DOI:10.14341/2072-0351-6228
55. Доскина Е.В. Применение витаминов группы B в патогенетическом лечении диабетической полинейропатии. Эффективная фармакотерапия. 2012;46:30-5 [Doskina EV. Primenenie vitaminov gruppy B v patogeneticheskom lechenii diabeticheskoi polineiropatii. Effective Pharmacotherapy. 2012;46:30-5 (in Russian)].
56. Храмилин В.Н., Андреева В.Л., Демидова И.Ю. Комбинированная терапия болевой диабетической полинейропатии: результаты пилотного исследования. Фарматека. 2014;16:48-53 [Khramilin VN, Andreeva VL, Demidova IIu. Kombinirovannaia terapiia bolevoi diabeticheskoi polineiropatii: rezul’taty pilotnogo issledovaniia. Farmateka. 2014;16:48-53 (in Russian)].
57. Котова О.В. Диабетическая нейропатия. Применение нейротропных витаминов. Поликлиника. 2015;1(2):36-9 [Kotova OV. Diabetic neuropathy. Application of neurotropic vitamins. Polyclinic = Poliklinika. 2015;1(2):36-9 (in Russian)].
58. Дубинина И.И., Берстнева С.В., Баранов В.В., Азимкова Л.В. Эффективность комбинированной терапии диабетической дистальной нейропатии у больных сахарным диабетом 2 типа. Сахарный диабет. 2016;4:315-21 [Dubinina II, Berstneva SV, Baranov VV, Azimkova LV. Efficacy of complex pathogenic therapy of diabetic distal neuropathy in patients with type 2 diabetes mellitus. Diabetes Mellitus. 2016;19(4):315-21 (in Russian)]. DOI:10.14341/DM7637DOI:10.14341/DM7637
59. Штаймец С.В., Ченцова Т.С., Катина М.М., Письменный И.В. Профилактика поздних неврологических и хирургических осложнений сахарного диабета в условиях дневного стационара городской поликлиники. Профилактическая медицина. 2020;5:139-43 [Shtaimets SV, Chencova TS, Katina MM, Pismennyy IV. Prevention of late neurological and surgical complications of diabetes mellitus in the daycare center of the city clinic. Profilakticheskaia meditsina. 2020;5:139-43 (in Russian)]. DOI:10.17116/profmed202023051139
60. Кукес В., Ших Е., Махова В. Отечественные препараты «Apтpозaн®» и «Бенфолипен®»: возможности комбинированной терапии болевого синдрома. Врач. 2009;7:57-60 [Kukes V, Shikh E, Makhova V. Otechestvennye preparaty “Aptpozan®” i “Benfolipen®”: vozmozhnosti kombinirovannoi terapii bolevogo sindroma. Vrach. 2009;7:57-60 (in Russian)].
61. Подлипалин А. Препарат Комбилипен в комбинированной терапии хронической боли в спине. Врач. 2009;8:28-9 [Podlipalin A. Preparat Kombilipen v kombinirovannoi terapii khronicheskoi boli v spine. Vrach. 2009;8:28-9 (in Russian)].
62. Батышева Т.Т., Отческая О.В., Хозова А.А., и др. Эффективность применения комбинации препаратов артрозан и комбилипен у пациентов с острой болью в нижней части спины. Журнал неврологии и психиатрии им. С.С. Корсакова. 2011;9(2):41-4 [Batysheva TT, Otcheskaia OV, Khozova AA, et al. Effektivnost’ primeneniia kombinatsii preparatov artrozan i kombilipen u patsientov s ostroi bol’iu v nizhnei chasti spiny. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2011;9(2):41-4 [(in Russian)].
63. Камчатнов П.Р., Умарова Х.Я., Осмаева З.Х. Применение нестероидных противовоспалительных препаратов и комплекса витаминов группы В у пациентов с поясничной болью. Consilium Medicum. 2014;16(9):70-5 [Kamchatnov PR, Umarova KhIa, Osmaeva ZKh. The use of non-steroidal anti-inflammatory drugs and a complex of B vitamins in patients with lumbar pain. Consilium Medicum. 2014;16(9):70-5 (in Russian)].
64. Умарова Х.Я., Камчатнов П.Р., Осмаева З.Х. Нестероидные противовоспалительные препараты и витамины группы В у пациентов с поясничной болью. РМЖ. Медицинское обозрение. 2015;10:584-8 [Umarova KhIa, Kamchatnov PR, Osmaeva ZKh. Nesteroidnye protivovospalitel’nye preparaty i vitaminy gruppy V u patsientov s poiasnichnoi bol’iu. RMZh. Meditsinskoe obozrenie. 2015;10:584-8 (in Russian)].
65. Исайкин А.И., Черненко О.А., Иванова М.А., Стиценко А.Н. Боль в пояснице, обусловленная патологией межпозвоночных дисков. Consilium Medicum. 2015;17(2): 52-60 [Isaykin AI, Chernenko OA, Ivanova MA, Stitsenko AN. Back pain caused by disorders of the intervertebral discs. Consilium Medicum. 2015;17(2):52-60 (in Russian)].
DOI:10.26442/2075-1753_2015.2.52-60
66. Трухан Д.И., Давыдов Е.Л. Дорсалгия: актуальные аспекты терапии на этапе оказания первичной медико-санитарной помощи. Consilium Medicum. 2015;9:82-7 [Trukhan DI, Davydov EL. Dorsalgia: topical aspects of treatment at stages of primary health care. Consilium Medicum. 2015;7(9):82-7 (in Russian)]. DOI:10.26442/2075-1753_2015.9.82-87
67. Трухан Д.И., Викторова И.А., Трухан Л.Ю. Изменение органов и тканей полости рта при заболеваниях внутренних органов. М.: Практическая медицина, 2012 [Trukhan DI, Viktorova IA, Trukhan LIu. Izmenenie organov i tkanei polosti rta pri zabolevaniiakh vnutrennikh organov. Moscow: Prakticheskaia meditsina, 2012 (in Russian)].
________________________________________________
2023;26(2S):1-157 (in Russian). DOI:10.14341/DM13042
2. Shestakova EA, Lunina EY, Galstyan GR, et al. Type 2 diabetes and prediabetes prevalence in patients with different risk factor combinations in the NATION study. Diabetes Mellitus. 2020;23(1):4-11 (in Russian). DOI:10.14341/DM12286
3. International Diabetes Federation. IDF Diabetes Atlas, 9th ed. Brussels, Belgium, 2019. Available at: https://www.diabetesatlas.org. Accessed: 12.12.2023.
4. Jensen TS, Karlsson P, Gylfadottir SS, et al. Painful and non-painful diabetic neuropathy, diagnostic challenges and implications for future management. Brain.
2021;144(6):1632-45. DOI:10.1093/brain/awab079
5. Ang L, Mizokami-Stout K, Eid SA, et al. The conundrum of diabetic neuropathies – Past, present, and future. J Diabetes Complications. 2022;36(11):108334. DOI:10.1016/j.jdiacomp.2022.108334
6. Sakharnyi diabet 2-go tipa u vzroslykh. Klinicheskie rekomendatsii. 2022. Available at: https://cr.minzdrav.gov.ru/recomend/290_2. Accessed: 12.12.2023 (in Russian).
7. Sakharnyi diabet 1-go tipa u vzroslykh. Klinicheskie rekomendatsii. 2022. Available at: https://cr.minzdrav.gov.ru/recomend/286_2. Accessed: 12.12.2023 (in Russian).
8. American Diabetes Association Professional Practice Committee. 12. Retinopathy, Neuropathy, and Foot Care: Standards of Medical Care in Diabetes-2022. Diabetes Care. 2022;45(Suppl. 1):S185-94. DOI:10.2337/dc22-S012
9. Hicks CW, Selvin E. Epidemiology of Peripheral Neuropathy and Lower Extremity Disease in Diabetes. Curr Diab Rep. 2019;19(10):86. DOI:10.1007/s11892-019-1212-8
10. Anastasi JK, Capili B. Detecting Peripheral Neuropathy in Patients with Diabetes, Prediabetes and other High-Risk Conditions: An Advanced Practice Nurse’s Perspective. J Med Clin Nurs. 2022;3(2). DOI:10.47363/jmcn/2022(3)143
11. Elafros MA, Andersen H, Bennett DL, et al. Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments. Lancet Neurol. 2022;21(10):922-36. DOI:10.1016/S1474-4422(22)00188-0
12. Quiroz-Aldave J, Durand-Vásquez M, Gamarra-Osorio E, et al. Diabetic neuropathy: Past, present, and future. Caspian J Intern Med. 2023;14(2):153-69. DOI:10.22088/cjim.14.2.153
13. Fan Q, Gordon Smith A. Recent updates in the treatment of diabetic polyneuropathy. Fac Rev. 2022;11:30. DOI:10.12703/r/11-30
14. Ziegler D, Tesfaye S, Spallone V, et al. Screening, diagnosis and management of diabetic sensorimotor polyneuropathy in clinical practice: International expert consensus recommendations. Diabetes Res Clin Pract. 2022;186:109063. DOI:10.1016/j.diabres.2021.109063
15. Ziegler D, Papanas N, Schnell O, et al. Current concepts in the management of diabetic polyneuropathy. J Diabetes Investig. 2021;12(4):464-75. DOI:10.1111/jdi.13401
16. Ziegler D. Pathogenetic treatments for diabetic peripheral neuropathy. Diabetes Res Clin Pract. 2023;206(Suppl. 1):110764. DOI:10.1016/j.diabres.2023.110764
17. Bondar A, Popa AR, Papanas N, et al. Diabetic neuropathy: A narrative review of risk factors, classification, screening and current pathogenic treatment options (Review). Exp Ther Med. 2021;22(1):690. DOI:10.3892/etm.2021.10122
18. Winkler G, Kempler P. Pathomechanism of diabetic neuropathy: background of the pathogenesis-oriented therapy. Orv Hetil. 2010;151(24):971-81. DOI:10.1556/OH.2010.28898
19. Várkonyi T, Körei A, Putz Z, et al. Advances in the management of diabetic neuropathy. Minerva Med. 2017;108(5):419-37. DOI:10.23736/S0026-4806.17.05257-0
20. Mrowicka M, Mrowicki J, Dragan G, Majsterek I. The importance of thiamine (vitamin B1) in humans. Biosci Rep. 2023;43(10). DOI:10.1042/BSR20230374
21. Bozic I, Lavrnja I. Thiamine and benfotiamine: Focus on their therapeutic potential. Heliyon. 2023;9(11):e21839. DOI:10.1016/j.heliyon.2023.e21839
22. Nardone R, Höller Y, Storti M, et al. Thiamine deficiency induced neurochemical, neuroanatomical, and neuropsychological alterations: a reappraisal. ScientificWorldJournal. 2013;2013:309143. DOI:10.1155/2013/309143
23. Beltramo E, Mazzeo A, Porta M. Thiamine and diabetes: back to the future? Acta Diabetol. 2021;58(11):1433-9. DOI:10.1007/s00592-021-01752-4
24. Thornalley PJ. The potential role of thiamine (vitamin B1) in diabetic complications. Curr Diabetes Rev. 2005;1(3):287-98. DOI:10.2174/157339905774574383
25. Obrenovich ME, Monnier VM. Vitamin B1 blocks damage caused by hyperglycemia. Sci Aging Knowledge Environ. 2003;2003(10):PE6. DOI:10.1126/sageke.2003.10.pe6
26. Page GL, Laight D, Cummings MH. Thiamine deficiency in diabetes mellitus and the impact of thiamine replacement on glucose metabolism and vascular disease. Int J Clin Pract. 2011;65(6):684-90. DOI:10.1111/j.1742-1241.2011.02680.x
27. Pácal L, Kuricová K, Kaňková K. Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation? World J Diabetes. 2014;5(3):288-95. DOI:10.4239/wjd.v5.i3.288
28. Khan MU, Mubeen M, Chohan HK, et al. Correlation of Fasting Blood Sugar and Glycated Hemoglobin (HbA1c) With Thiamine Levels in Diabetic Patients. Cureus. 2023;15(9):e46178. DOI:10.7759/cureus.46178
29. Dakshinamurti K. Vitamins and their derivatives in the prevention and treatment of metabolic syndrome diseases (diabetes). Can J Physiol Pharmacol.
2015;93(5):355-62. DOI:10.1139/cjpp-2014-0479
30. Balakumar P, Rohilla A, Krishan P, et al. The multifaceted therapeutic potential of benfotiamine. Pharmacol Res. 2010;61(6):482-8. DOI:10.1016/j.phrs.2010.02.008
31. Raj V, Ojha S, Howarth FC, et al. Therapeutic potential of benfotiamine and its molecular targets. Eur Rev Med Pharmacol Sci. 2018;22(10):3261-73. DOI:10.26355/eurrev_201805_15089
32. Sambon M, Wins P, Bettendorff L. Neuroprotective Effects of Thiamine and Precursors with Higher Bioavailability: Focus on Benfotiamine and Dibenzoylthiamine. Int J Mol Sci. 2021;22(11). DOI:10.3390/ijms22115418
33. Bettendorff L. Synthetic Thioesters of Thiamine: Promising Tools for Slowing Progression of Neurodegenerative Diseases. Int J Mol Sci. 2023;24(14). DOI:10.3390/ijms241411296
34. Nikolić A, Kacar A, Lavrnić D, et al. [The effect of benfothiamine in the therapy of diabetic polyneuropathy]. Srp Arh Celok Lek. 2009;137(11-12):594-600 (in Serbian). DOI:10.2298/sarh0912594n
35. Abosamak NR, Gupta V. Vitamin B6 (Pyridoxine). In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2024.
36. Tein I. Recent advances in neurometabolic diseases: The genetic role in the modern era. Epilepsy Behav. 2023;145:109338. DOI:10.1016/j.yebeh.2023.109338
37. Abbas ZG, Swai AB. Evaluation of the efficacy of thiamine and pyridoxine in the treatment of symptomatic diabetic peripheral neuropathy. East Afr Med J. 1997;74(12):803-8.
38. Eckert M, Schejbal P. Therapy of neuropathies with a vitamin B combination. Symptomatic treatment of painful diseases of the peripheral nervous system with a combination preparation of thiamine, pyridoxine and cyanocobalamin. Fortschr Med. 1992;110(29):544-8.
39. Stracke H, Lindemann A, Federlin K. A benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy. Exp Clin Endocrinol Diabetes. 1996;104(4):311-6.
DOI:10.1055/s-0029-1211460
40. Guilland JC, Aimone-Gastin I. [Vitamin B12 (cobalamin)]. Rev Prat. 2013;63(8):1085-7, 1089-90 (in French).
41. Tanaka H. Old or new medicine? Vitamin B12 and peripheral nerve neuropathy. Brain Nerve. 2013;65(9):1077-82.
42. França DS, Souza AL, Almeida KR, et al. B vitamins induce an antinociceptive effect in the acetic acid and formaldehyde models of nociception in mice. Eur J Pharmacol. 2001;421(3):157-64. DOI:10.1016/s0014-2999(01)01038-x
43. Schleicher E, Didangelos T, Kotzakioulafi E, et al. Clinical Pathobiochemistry of Vitamin B(12) Deficiency: Improving Our Understanding by Exploring Novel Mechanisms with a Focus on Diabetic Neuropathy. Nutrients. 2023;15(11). DOI:10.3390/nu15112597
44. Didangelos T, Karlafti E, Kotzakioulafi E, et al. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2021;13(2). DOI:10.3390/nu13020395
45. Jin HY, Lee KA, Kim YJ, et al. Bidirectional association between diabetic peripheral neuropathy and vitamin B12 deficiency: Two longitudinal 9-year follow-up studies using a national sample cohort. Prim Care Diabetes. 2023;17(5):436-43. DOI:10.1016/j.pcd.2023.06.006
46. Sun Y, Lai MS, Lu CJ. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwan. 2005;14(2):48-54.
47. Xu Q, Pan J, Yu J, et al. Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy. Diabetes Res Clin Pract. 2013;101(2):99-105. DOI:10.1016/j.diabres.2013.03.033
48. Sawangjit R, Thongphui S, Chaichompu W, Phumart P. Efficacy and Safety of Mecobalamin on Peripheral Neuropathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Altern Complement Med. 2020;26(12):1117-29. DOI:10.1089/acm.2020.0068
49. Ametov AS, Soluyanova TN. The role of B vitamins in the treatment of diabetic polyneuropathy. Medical Counsil. 2010;7:18-20 (in Russian).
50. Vrolijk MF, Opperhuizen A, Jansen EHJM, et al. The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. Toxicol In Vitro. 2017;44:206-12. DOI:10.1016/j.tiv.2017.07.009
51. Kukushkin ML. Vitamins of group B (B1, B6, B12) in complex therapy of pain syndromes. Russian Journal of Pain. 2019;17(3):39-45 (in Russian). DOI:10.25731/RASP.2019.03.31
52. Skeletno-myshechnye (nespetsificheskie) boli v nizhnei chasti spiny. Klinicheskie rekomendatsii. 2023. Available at: https://cr.minzdrav.gov.ru/recomend/778_1. Accessed: 10.04.2024 (in Russian).
53. Diskogennaia poiasnichno-kresttsovaia radikulopatiia. Klinicheskie rekomendatsii. 2023. Available at: https://cr.minzdrav.gov.ru/recomend/777_1. Accessed: 12.12.2023 (in Russian).
54. Dubinina II, Karapysh TV, Nosova NF. Efficacy of combined treatment of distal polyneuropathy in patients with type 2 diabetes mellitus and concomitant primaryhypothyroidism. Diabetes Mellitus. 2011;14(3):76-9 (in Russian). DOI:10.14341/2072-0351-6228
55. Doskina EV. Primenenie vitaminov gruppy B v patogeneticheskom lechenii diabeticheskoi polineiropatii. Effective Pharmacotherapy. 2012;46:30-5 (in Russian).
56. Khramilin VN, Andreeva VL, Demidova IIu. Kombinirovannaia terapiia bolevoi diabeticheskoi polineiropatii: rezul’taty pilotnogo issledovaniia. Farmateka. 2014;16:48-53 (in Russian).
57. Kotova OV. Diabetic neuropathy. Application of neurotropic vitamins. Polyclinic = Poliklinika. 2015;1(2):36-9 (in Russian).
58. Dubinina II, Berstneva SV, Baranov VV, Azimkova LV. Efficacy of complex pathogenic therapy of diabetic distal neuropathy in patients with type 2 diabetes mellitus. Diabetes Mellitus. 2016;19(4):315-21 (in Russian). DOI:10.14341/DM7637DOI:10.14341/DM7637
59. Shtaimets SV, Chencova TS, Katina MM, Pismennyy IV. Prevention of late neurological and surgical complications of diabetes mellitus in the daycare center of the city clinic. Profilakticheskaia meditsina. 2020;5:139-43 (in Russian). DOI:10.17116/profmed202023051139
60. Kukes V, Shikh E, Makhova V. Otechestvennye preparaty “Aptpozan®” i “Benfolipen®”: vozmozhnosti kombinirovannoi terapii bolevogo sindroma. Vrach. 2009;7:57-60 (in Russian).
61. Podlipalin A. Preparat Kombilipen v kombinirovannoi terapii khronicheskoi boli v spine. Vrach. 2009;8:28-9 (in Russian).
62. Batysheva TT, Otcheskaia OV, Khozova AA, et al. Effektivnost’ primeneniia kombinatsii preparatov artrozan i kombilipen u patsientov s ostroi bol’iu v nizhnei chasti spiny. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2011;9(2):41-4 [(in Russian).
63. Kamchatnov PR, Umarova KhIa, Osmaeva ZKh. The use of non-steroidal anti-inflammatory drugs and a complex of B vitamins in patients with lumbar pain. Consilium Medicum. 2014;16(9):70-5 (in Russian).
64. Umarova KhIa, Kamchatnov PR, Osmaeva ZKh. Nesteroidnye protivovospalitel’nye preparaty i vitaminy gruppy V u patsientov s poiasnichnoi bol’iu. RMZh. Meditsinskoe obozrenie. 2015;10:584-8 (in Russian).
65. Isaykin AI, Chernenko OA, Ivanova MA, Stitsenko AN. Back pain caused by disorders of the intervertebral discs. Consilium Medicum. 2015;17(2):52-60 (in Russian). DOI:10.26442/2075-1753_2015.2.52-60
66. Trukhan DI, Davydov EL. Dorsalgia: topical aspects of treatment at stages of primary health care. Consilium Medicum. 2015;7(9):82-7 (in Russian).
DOI:10.26442/2075-1753_2015.9.82-87
67. Trukhan DI, Viktorova IA, Trukhan LIu. Izmenenie organov i tkanei polosti rta pri zabolevaniiakh vnutrennikh organov. Moscow: Prakticheskaia meditsina, 2012 (in Russian).
Авторы
Д.И. Трухан*, И.В. Друк
ФГБОУ ВО «Омский государственный медицинский университет» Минздрава России, Омск, Россия
*dmitry_trukhan@mail.ru
Omsk State Medical University, Omsk, Russia
*dmitry_trukhan@mail.ru
ФГБОУ ВО «Омский государственный медицинский университет» Минздрава России, Омск, Россия
*dmitry_trukhan@mail.ru
________________________________________________
Omsk State Medical University, Omsk, Russia
*dmitry_trukhan@mail.ru
Цель портала OmniDoctor – предоставление профессиональной информации врачам, провизорам и фармацевтам.