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Эффективность сопроводительной терапии адеметионином при проведении противоопухолевой лекарственной терапии
Эффективность сопроводительной терапии адеметионином при проведении противоопухолевой лекарственной терапии
Огнерубов Н.А. Эффективность сопроводительной терапии адеметионином при проведении противоопухолевой лекарственной терапии. Consilium Medicum. 2024;26(6):351–361.
DOI: 10.26442/20751753.2024.6.202857
© ООО «КОНСИЛИУМ МЕДИКУМ», 2024 г.
DOI: 10.26442/20751753.2024.6.202857
© ООО «КОНСИЛИУМ МЕДИКУМ», 2024 г.
________________________________________________
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Аннотация
Повреждения печени, вызванные лекарственной противоопухолевой терапией, представляют частое заболевание у больных, страдающих злокачественными новообразованиями. Это обусловлено внедрением в лечебный процесс новых инновационных препаратов, существенно увеличивающих продолжительность и качество жизни, но также и частоту побочных эффектов с поражением печени различной степени тяжести. Диапазон гепатотоксичности при проведении химиотерапии колеблется от 5 до 100%. Спектр морфологических изменений печени при этом многообразен, характеризуется развитием острого и хронического поражения печени с повреждением гепатоцитов и исходом в фиброз. Рассмотрены клинические особенности диагностики различных типов, вариантов и фенотипов лекарственно-индуцированного повреждения печени при химиотерапии солидных опухолей и гемобластозов. Статья содержит обзор литературы, посвященной вопросам сопроводительной терапии с применением адеметионина с целью уменьшения метаболических нарушений, печеночной токсичности, обусловленной проведением цитотоксической терапии. Клинические и биохимические эффекты при этом сохраняются длительно по окончании лечения. Подробно изложены результаты применения адеметионина в коррекции клинических симптомов, таких как усталость. Представленные материалы позволят практическим врачам пересмотреть роль сопроводительной терапии с использованием адеметионина для предупреждения и уменьшения проявлений гепатотоксичности, индуцированной полихимиотерапией. Такое решение позволяет реализовать персонализированный подход к пациентам со злокачественными заболеваниями, тем самым значимо улучшить медицинскую помощь, а также увеличить продолжительность и качество жизни.
Ключевые слова: лекарственные повреждения печени, гепатотоксичность, полихимиотерапия, сопроводительная терапия, адеметионин
Keywords: drug-induced liver injury, hepatotoxicity, polychemotherapy, concomitant therapy, ademetionine
Ключевые слова: лекарственные повреждения печени, гепатотоксичность, полихимиотерапия, сопроводительная терапия, адеметионин
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Keywords: drug-induced liver injury, hepatotoxicity, polychemotherapy, concomitant therapy, ademetionine
Полный текст
Список литературы
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2012;104(4):165-84. DOI:10.4321/s1130-01082012000400002
5. Mudd TW, Guddati AK. Management of hepatotoxicity of chemotherapy and targeted agents. Am J Cancer Res. 2021;11(7):3461-74.
6. Colsky J, Greenspan EM, Warren TN. Hepatic fibrosis in children with acute leukemia after therapy with folic acid antagonists. AMA Arch Pathol. 1955;59:198-206.
7. Hoofnagle JH, Björnsson ES. Drug-Induced Liver Injury – Types and Phenotypes. N Engl J Med. 2019;381(3):264-73. DOI:10.1056/NEJMra1816149
8. Sharma A, Houshyar R, Bhosale P, et al. Chemotherapy induced liver abnormalities: an imaging perspective. Clin Mol Hepatol. 2014;20(3):317-26. DOI:10.3350/cmh.2014.20.3.317
9. European Association for the Study of the Liver. EASL Clinical Practice Guidelines: Drug-Induced Liver Injury. J Hepatol. 2019;70(6):1222-61. DOI:10.1016/j.jhep.2019.02.014
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11. Cho YA, Han JM, Kang SY, et al. Analysis of Risk Factors for Hepatotoxicity Induced by Immune Checkpoint Inhibitors. J Immunother. 2021;44(1):16-21. DOI:10.1097/CJI.0000000000000347
12. Larkin J, Chiarion-Sileni V, Gonzalez R, et al. Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma. N Engl J Med. 2015;373(1):23-34. DOI:10.1056/NEJMoa1504030
13. Wang DY, Salem JE, Cohen JV, et al. Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-analysis. JAMA Oncol. 2018;4(12):1721-8. DOI:10.1001/jamaoncol.2018.3923
14. Wolchok JD, Neyns B, Linette G, et al. Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study. Lancet Oncol. 2010;11(2):155-64. DOI:10.1016/S1470-2045(09)70334-1
15. Cohen JV, Dougan M, Zubiri L, et al. Liver biopsy findings in patients on immune checkpoint inhibitors. Mod Pathol. 2021;34(2):426-37. DOI:10.1038/s41379-020-00653-1
16. Thomas R, Sebastian B, George T, et al. A review of the imaging manifestations of immune check point inhibitor toxicities. Clin Imaging. 2020;64:70-9. DOI:10.1016/j.clinimag.2020.04.007
17. Tsung I, Dolan R, Lao CD, et al. Liver injury is most commonly due to hepatic metastases rather than drug hepatotoxicity during pembrolizumab immunotherapy. Aliment Pharmacol Ther. 2019;50(7):800-8. DOI:10.1111/apt.15413
18. Andrade RJ, Lucena MI, Fernández MC, et al. Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period. Gastroenterology. 2005;129(2):512-21.
19. Shen T, Liu Y, Shang J, et al. Incidence and Etiology of Drug-Induced Liver Injury in Mainland China. Gastroenterology. 2019;156(8):2230-41.e11. DOI:10.1053/j.gastro.2019.02.002
20. Benić MS, Nežić L, Vujić-Aleksić V, Mititelu-Tartau L. Novel Therapies for the Treatment of Drug-Induced Liver Injury: A Systematic Review. Front Pharmacol. 2022;12:785790. DOI:10.3389/fphar.2021.785790
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53. Lawrence DP, Kupelnick B, Miller K, et al. Evidence report on the occurrence, assessment, and treatment of fatigue in cancer patients. J Natl Cancer Inst Monogr. 2004;(32):40-50. DOI:10.1093/jncimonographs/lgh027
54. Servaes P, Verhagen C, Bleijenberg G. Fatigue in cancer patients during and after treatment: prevalence, correlates and interventions. Eur J Cancer.
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55. Swain MG, Jones DEJ. Fatigue in chronic liver disease: New insights and therapeutic approaches. Liver Int. 2019;39(1):6-19. DOI:10.1111/liv.13919
56. Jopson L, Dyson JK, Jones DE. Understanding and Treating Fatigue in Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis. Clin Liver Dis. 2016;20(1):131-42. DOI:10.1016/j.cld.2015.08.007
57. Cauch-Dudek K, Abbey S, Stewart DE, Heathcote EJ. Fatigue in primary biliary cirrhosis. Gut. 1998;43(5):705-10. DOI:10.1136/gut.43.5.705
58. Bower JE, Ganz PA, Desmond KA, et al. Fatigue in long-term breast carcinoma survivors: a longitudinal investigation. Cancer. 2006;106(4):751-8. DOI:10.1002/cncr.21671
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65. Mahmood N, Cheishvili D, Arakelian A, et al. Methyl donor S-adenosylmethionine (SAM) supplementation attenuates breast cancer growth, invasion, and metastasis in vivo; therapeutic and chemopreventive applications. Oncotarget. 2017;9(4):5169-83. DOI:10.18632/oncotarget.23704
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Авторы
Н.А. Огнерубов*
Пензенский институт усовершенствования врачей – филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Пенза, Россия
*ognerubov_n.a@mail.ru
Penza Institute for Advanced Training of Physicians – branch of the Russian Medical Academy of Continuous Professional Education, Penza, Russia
*ognerubov_n.a@mail.ru
Пензенский институт усовершенствования врачей – филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Пенза, Россия
*ognerubov_n.a@mail.ru
________________________________________________
Penza Institute for Advanced Training of Physicians – branch of the Russian Medical Academy of Continuous Professional Education, Penza, Russia
*ognerubov_n.a@mail.ru
Цель портала OmniDoctor – предоставление профессиональной информации врачам, провизорам и фармацевтам.