1. Рукша Ю.Д., Козинец М.С., Хворик Ф.Д. Профилактика инфекций, передаваемых половым путем, в молодежной среде. В: Современные достижения молодых ученых в медицине – 2022. Сборник материалов IX Республиканской научно-практической конференции с международным участием. Гродно. 2022; с. 242-5 [Ruksha JD, Kozinets MS, Khvorik FD. Prevention of sexually transmitted infections among young people. In: Sovremennye dostizheniia molodykh uchenykh v meditsine – 2022. In: Sbornik materialov IX Respublikanskoi nauchno-prakticheskoi konferentsii s mezhdunarodnym uchastiem . Grodno. 2022; p. 242-5 (in Russian)].
2. Aggarwal S, Singh AK, Balaji S, Ambalkar D. Sexually transmitted infections (STIs) and its changing scenario: a scoping review. Comb Chem High Throughput Screen. 2022;25(10):1630-8. DOI:10.2174/1386207324666210301093001
3. Tuddenham S, Hamill MM, Ghanem KG. Diagnosis and treatment of sexually transmitted infections: a review. JAMA. 2022;327(2):161-72.
4. Нурадилова Д.М. Современный взгляд на проблему воспалительных заболеваний органов малого таза у женщин репродуктивного возраста (обзор литературы). Вестник КазНМУ. 2015;(4):21-6 [Nuradilova DM. Sovremennyi vzgliad na problemu vospalitel'nykh zabolevanii organov malogo taza u zhenshchin reproduktivnogo vozrasta (obzor literatury). Vestnik KazNMU. 2015;(4):21-6 (in Russian)].
5. Musher DM. Doxycycline to treat community-acquired pneumonia. Clin Infect Dis. 2023;76(4):692-3.
6. World Health Organization. The WHO AWaRe (access, watch, reserve) antibiotic book. World Health Organization, 2022.
7. Стратегия контроля антимикробной терапии в лечебно-профилактических учреждениях для стран с низким и средним уровнем дохода. Практическое пособие ВОЗ. Режим доступа: https://cdn.who.int/media/docs/default-source/antimicrobial-resistance/9789240003095-rus.pdf?sfvrsn=.... Ссылка ативна на 08.08.2024 [Strategiia kontrolia antimikrobnoi terapii v lechebno-profilakticheskikh uchrezhdeniiakh dlia stran s nizkim i srednim urovnem dokhoda. Prakticheskoe posobie VOZ. Available at: https://cdn.who.int/media/docs/default-source/antimicrobial-resistance/9789240003095-rus.pdf?sfvrsn=.... Accessed: 08.08.2024 (in Russian)].
8. Черкашина Н.В., Дроздова Л.И., Махортов В.Л., и др. Анализ современного состояния проблемы использования антибиотиков в качестве кормовой добавки. Аграрный вестник Урала. 2011;(3):39-42 [Cherkashina NV, Drozdova LI, Makhortov VL, et al. Analiz sovremennogo sostoianiia problemy ispol'zovaniia antibiotikov v kachestve kormovoi dobavki. Agrarnyi vestnik Urala. 2011;(3):39-42 (in Russian)].
9. Choi SH, Cesar A, Snow TAC, et al. Efficacy of Doxycycline for Mild-to-Moderate Community-Acquired Pneumonia in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Clin Infect Dis. 2023;76(4):683-91. DOI:10.1093/cid/ciac615
10. Akhyani M, Ehsani AH, Ghiasi M, Jafari AK. Comparison of efficacy of azithromycin vs. doxycycline in the treatment of rosacea: a randomized open clinical trial. Int J Dermatol. 2008;47(3):284-8. DOI:10.1111/j.1365-4632.2008.03445.x
11. Зырянов С.К., Голуб А.В., Козлов Р.С. Доксициклин в современной клинической практике. Клиническая микробиология и антимикробная химиотерапия. 2020;22(1):21-8 [Zyrianov SK, Golub AV, Kozlov RS. Doksitsiklin v sovremennoi klinicheskoi praktike. Klinicheskaia mikrobiologiia i antimikrobnaia khimioterapiia. 2020;22(1):21-8 (in Russian)].
12. Mahajan VK. Lyme Disease: An Overview. Indian Dermatol Online J. 2023;14(5):594-604. DOI:10.4103/idoj.idoj_418_22
13. Reynolds RV, Yeung H, Cheng CE, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2024;90(5):1006.e1-30. DOI:10.1016/j.jaad.2023.12.017
14. Zakeri B, Wright GD. Chemical biology of tetracycline antibiotics. Biochem Cell Biol. 2008;86(2):124-36. DOI:10.1139/O08-002. PMID: 18443626
15. Белоусов Ю.Б., Данилов А.Н., Зырянов С.К., и др. Доксициклинассоциированный лекарственный эзофагит: современные фармакологические возможности решения клинической проблемы. Consilium Medicum. 2012;14(4):57-63 [Belousov YB, Danilov AN, Zyryanov SK, et al. Doksitsiklinassotsiirovannyi lekarstvennyi ezofagit: sovremennye farmakologicheskie vozmozhnosti resheniia klinicheskoi problemy. Consilium Medicum. 2012;14(4):57-63 (in Russian)].
16. Ghasemi K, Ghasemi K. A Brief look at antitumor effects of doxycycline in the treatment of colorectal cancer and combination therapies. Eur J Pharmacol. 2022;916:174593.
17. Самцов А.В. Патогенетическая терапия розацеа системными тетрациклинами. Вестник дерматологии и венерологии. 2023;99(6):23-8 [Samtsov AV. Pathogenetic therapy of rosacea with systemic tetracyclines. Vestnik dermatologii i venerologii. 2023;99(6):23-8 (in Russian)]. DOI:10.25208/vdv14701
18. Nguyen C, Kuceki G, Birdsall M, et al. Rosacea: Practical Guidance and Challenges for Clinical Management. Clin Cosmet Invest Dermatol. 2024;17:175-90. DOI:10.2147/CCID.S391705
19. Nakagawa T, Kakizoe Y, Iwata Y, et al. Doxycycline attenuates cisplatin-induced acute kidney injury through pleiotropic effects. Am J Physiol Renal Physiol. 2018;315(5):F1347-57.
20. Fasciana T, Capra G, Lipari D, et al. Sexually transmitted diseases: Diagnosis and control. In J Environ Res Public Health. 2022;19(9):5293. DOI:10.3390/ijerph19095293
21. Хламидийная инфекция. Клинические рекомендации МЗ РФ. 2024. Режим доступа: https://diseases.medelement.com/disease/%D1%85%D0%BB%D0%B0%D0%BC%D0%B8%D0%B4%D0%B8%D0%B9%D0%BD%D0%B0.... Ссылка активна на 08.08.2024 [Khlamidiinaia infektsiia. Klinicheskie rekomendatsii MZ RF. 2024. Available at: https://diseases.medelement.com/disease/%D1%85%D0%BB%D0%B0%D0%BC%D0%B8%D0%B4%D0%B8%D0%B9%D0%BD%D0%B0.... Accessed: 08.08.2024 (in Russian)].
22. Урогенитальные заболевания, вызванные Mycoplasma genitalium. Клинические рекомендации МЗ РФ. 2024. Режим доступа: https://diseases.medelement.com/disease/%D1%83%D1%80%D0%BE%D0%B3%D0%B5%D0%BD%D0%B8%D1%82%D0%B0%D0%BB.... Ссылка активна на 08.08.2024 [Urogenital'nye zabolevaniia, vyzvannye Mycoplasma genitalium. Klinicheskie rekomendatsii MZ RF. 2024. Available at: https://diseases.medelement.com/disease/%D1%85%D0%BB%D0%B0%D0%BC%D0%B8%D0%B4%D0%B8%D0%B9%D0%BD%D0%B0.... Accessed: 08.08.2024 (in Russian)].
23. EAU guidelines, 2024. Available at: https://d56bochluxqnz.cloudfront.net/documents/full-guideline/EAU-Guidelines-on-UrologicalInfections.... Accessed: 15.08.2024.
24. Rekart ML. Doxycycline: "New" treatment of choice for genital chlamydia infections. British Columbia Med J. 2004;46(10):503.
25. Barberán J, de la Cuerda A, Tejeda González MI, et al. Safety of fluoroquinolones. Rev Esp Quimioter. 2024;37(2):127-33. DOI:10.37201/req/143.2023
26. Стрыгин А.В., Несмиянов П.П., Толкачев Б.Е. Положительное влияние доксициклина на показатели мужской фертильности. Вестник Волгоградского государственного медицинского университета. 2015;12(4):9-12 [Strygin AV, Nesmiyanov PP, Tolkachev BE. Positive effects of doxycycline on male fertility. Journal of Volgograd State Medical University. 2015;12(4):9-12 (in Russian)].
27. Мухамедов Х.А., Черниченко И.И. Влияние хронического бактериального и абактериального простатита на репродуктивную систему. Тезисы XVI Общероссийского семинара «Репродуктивный потенциал России: версии и контраверсии» и IX Общероссийской конференции «FLORES VITAE. Контраверсии неонатальной медицины и педиатрии». 2022; с. 51-2 [Mukhamedov KhA, Chernichenko II. Vliianie khronicheskogo bakterial'nogo i abakterial'nogo prostatita na reproduktivnuiu sistemu. Tezisy XVI Obshcherossiiskogo seminara «Reproduktivnyi potentsial Rossii: versii i kontraversii» i IX Obshcherossiiskoi konferentsii «FLORES VITAE. Kontraversii neonatal'noi meditsiny i pediatrii». 2022; p. 51-2 (in Russian)].
28. Белый Л.Е. Хронический простатит и мужское бесплодие. Клинический разбор. 2023;4(4):89-93 [Belyi LE. Khronicheskii prostatit i muzhskoe besplodie. Klinicheskii razbor. 2023;4(4):89-93 (in Russian)].
29. Pasqualotto FF, Sharma RK, Nelson DR, et al. Relationship between oxidative stress, semen characteristics, and clinical diagnosis in men undergoing infertility investigation. Fertil Steril. 2000;73(3):459-64. DOI:10.1016/s0015-0282(99)00567-1
30. Popoola P, Oniyangi R, Ogunleye O, et al. Research Advances on the Adverse Effects of Antibiotics on Male Fertility. Afr J Biol Med Res. 2023;6(3):1-28. DOI:10.52589/AJBMRFI8HVFMN
31. Suarez SS. Control of hyperactivation in sperm. Hum Reprod Update. 2008;14(6):647-57.
32. Бебнева Т.Н., Дамиров К.Ф. Воспалительные заболевания органов малого таза. Гинекология. 2019;21(5):39-44 [Bebneva TN, Damirov KF. Vospalitel'nye zabolevaniia organov malogo taza. Ginekologiia. 2019;21(5):39-44 (in Russian)].
33. Potapov VO. Pelvic inflammatory diseases: clinical aspects of therapy and early rehabilitation of reproductive health. Infusion & Chemotherapy. 2020;(3.2):250-1.
34. Воспалительные болезни женских тазовых органов. Клинические рекомендации МЗ РФ 2024. Режим доступа: https://roag-portal.ru/projects_gynecology. Ссылка активна на 15.08.2024 [Vospalitel'nye bolezni zhenskikh tazovykh organov. Klinicheskie rekomendatsii MZ RF 2024. Rezhim dostupa: https://roag-portal.ru/projects_gynecology. Accessed: 15.08.2024 (in Russian)].
35. Yusuf H, Trent M. Management of Pelvic Inflammatory Disease in Clinical Practice. Ther Clin Risk Manag. 2023;19:183-92. DOI:10.2147/TCRM.S350750
36. Ali I, Alfarouk KO, Reshkin SJ, Ibrahim ME. Doxycycline as potential anti-cancer agent. Anticancer Agents Med Chem. 2017;17(12):1617-23. DOI:10.2174/1871520617666170213111951
37. Tu GG, Xu W, Huang H, Li S. Progress in the development of matrix metalloproteinase inhibitors. Curr Med Chem. 2008;15(14):1388-95.
38. Duivenvoorden WC, Popović SV, Lhoták S, et al. Doxycycline decreases tumor burden in a bone metastasis model of human breast cancer. Cancer Res. 2002;62(6):1588-91.
39. Kao GD, Jiang Z, Fernandes AM, et al. Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation. J Biol Chem. 2007;282(29):21206-12. DOI:10.1074/jbc.M703042200

________________________________________________

1. Ruksha JD, Kozinets MS, Khvorik FD. Prevention of sexually transmitted infections among young people. In: Sovremennye dostizheniia molodykh uchenykh v meditsine – 2022. In: Sbornik materialov IX Respublikanskoi nauchno-prakticheskoi konferentsii s mezhdunarodnym uchastiem . Grodno. 2022; p. 242-5 (in Russian).
2. Aggarwal S, Singh AK, Balaji S, Ambalkar D. Sexually transmitted infections (STIs) and its changing scenario: a scoping review. Comb Chem High Throughput Screen. 2022;25(10):1630-8. DOI:10.2174/1386207324666210301093001
3. Tuddenham S, Hamill MM, Ghanem KG. Diagnosis and treatment of sexually transmitted infections: a review. JAMA. 2022;327(2):161-72.
4. Nuradilova DM. Sovremennyi vzgliad na problemu vospalitel'nykh zabolevanii organov malogo taza u zhenshchin reproduktivnogo vozrasta (obzor literatury). Vestnik KazNMU.
2015;(4):21-6 (in Russian).
5. Musher DM. Doxycycline to treat community-acquired pneumonia. Clin Infect Dis. 2023;76(4):692-3.
6. World Health Organization. The WHO AWaRe (access, watch, reserve) antibiotic book. World Health Organization, 2022.
7. Strategiia kontrolia antimikrobnoi terapii v lechebno-profilakticheskikh uchrezhdeniiakh dlia stran s nizkim i srednim urovnem dokhoda. Prakticheskoe posobie VOZ. Available at: https://cdn.who.int/media/docs/default-source/antimicrobial-resistance/9789240003095-rus.pdf?sfvrsn=.... Accessed: 08.08.2024 (in Russian).
8. Cherkashina NV, Drozdova LI, Makhortov VL, et al. Analiz sovremennogo sostoianiia problemy ispol'zovaniia antibiotikov v kachestve kormovoi dobavki. Agrarnyi vestnik Urala.
2011;(3):39-42 (in Russian).
9. Choi SH, Cesar A, Snow TAC, et al. Efficacy of Doxycycline for Mild-to-Moderate Community-Acquired Pneumonia in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Clin Infect Dis. 2023;76(4):683-91. DOI:10.1093/cid/ciac615
10. Akhyani M, Ehsani AH, Ghiasi M, Jafari AK. Comparison of efficacy of azithromycin vs. doxycycline in the treatment of rosacea: a randomized open clinical trial. Int J Dermatol. 2008;47(3):284-8. DOI:10.1111/j.1365-4632.2008.03445.x
11. Zyrianov SK, Golub AV, Kozlov RS. Doksitsiklin v sovremennoi klinicheskoi praktike. Klinicheskaia mikrobiologiia i antimikrobnaia khimioterapiia. 2020;22(1):21-8 (in Russian).
12. Mahajan VK. Lyme Disease: An Overview. Indian Dermatol Online J. 2023;14(5):594-604. DOI:10.4103/idoj.idoj_418_22
13. Reynolds RV, Yeung H, Cheng CE, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2024;90(5):1006.e1-30. DOI:10.1016/j.jaad.2023.12.017
14. Zakeri B, Wright GD. Chemical biology of tetracycline antibiotics. Biochem Cell Biol. 2008;86(2):124-36. DOI:10.1139/O08-002. PMID: 18443626
15. Belousov YB, Danilov AN, Zyryanov SK, et al. Doksitsiklinassotsiirovannyi lekarstvennyi ezofagit: sovremennye farmakologicheskie vozmozhnosti resheniia klinicheskoi problemy. Consilium Medicum. 2012;14(4):57-63 (in Russian).
16. Ghasemi K, Ghasemi K. A Brief look at antitumor effects of doxycycline in the treatment of colorectal cancer and combination therapies. Eur J Pharmacol. 2022;916:174593.
17. Samtsov AV. Pathogenetic therapy of rosacea with systemic tetracyclines. Vestnik dermatologii i venerologii. 2023;99(6):23-8 (in Russian). DOI:10.25208/vdv14701
18. Nguyen C, Kuceki G, Birdsall M, et al. Rosacea: Practical Guidance and Challenges for Clinical Management. Clin Cosmet Invest Dermatol. 2024;17:175-90. DOI:10.2147/CCID.S391705
19. Nakagawa T, Kakizoe Y, Iwata Y, et al. Doxycycline attenuates cisplatin-induced acute kidney injury through pleiotropic effects. Am J Physiol Renal Physiol. 2018;315(5):F1347-57.
20. Fasciana T, Capra G, Lipari D, et al. Sexually transmitted diseases: Diagnosis and control. In J Environ Res Public Health. 2022;19(9):5293. DOI:10.3390/ijerph19095293
21. Khlamidiinaia infektsiia. Klinicheskie rekomendatsii MZ RF. 2024. Available at: https://diseases.medelement.com/disease/%D1%85%D0%BB%D0%B0%D0%BC%D0%B8%D0%B4%D0%B8%D0%B9%D0%BD%D0%B0.... Accessed: 08.08.2024 (in Russian).
22. Urogenital'nye zabolevaniia, vyzvannye Mycoplasma genitalium. Klinicheskie rekomendatsii MZ RF. 2024. Available at: https://diseases.medelement.com/disease/%D1%85%D0%BB%D0%B0%D0%BC%D0%B8%D0%B4%D0%B8%D0%B9%D0%BD%D0%B0.... Accessed: 08.08.2024 (in Russian).
23. EAU guidelines, 2024. Available at: https://d56bochluxqnz.cloudfront.net/documents/full-guideline/EAU-Guidelines-on-UrologicalInfections.... Accessed: 15.08.2024.
24. Rekart ML. Doxycycline: "New" treatment of choice for genital chlamydia infections. British Columbia Med J. 2004;46(10):503.
25. Barberán J, de la Cuerda A, Tejeda González MI, et al. Safety of fluoroquinolones. Rev Esp Quimioter. 2024;37(2):127-33. DOI:10.37201/req/143.2023
26. Strygin AV, Nesmiyanov PP, Tolkachev BE. Positive effects of doxycycline on male fertility. Journal of Volgograd State Medical University. 2015;12(4):9-12 (in Russian).
27. Mukhamedov KhA, Chernichenko II. Vliianie khronicheskogo bakterial'nogo i abakterial'nogo prostatita na reproduktivnuiu sistemu. Tezisy XVI Obshcherossiiskogo seminara «Reproduktivnyi potentsial Rossii: versii i kontraversii» i IX Obshcherossiiskoi konferentsii «FLORES VITAE. Kontraversii neonatal'noi meditsiny i pediatrii». 2022; p. 51-2 (in Russian).
28. Belyi LE. Khronicheskii prostatit i muzhskoe besplodie. Klinicheskii razbor. 2023;4(4):89-93 (in Russian).
29. Pasqualotto FF, Sharma RK, Nelson DR, et al. Relationship between oxidative stress, semen characteristics, and clinical diagnosis in men undergoing infertility investigation. Fertil Steril. 2000;73(3):459-64. DOI:10.1016/s0015-0282(99)00567-1
30. Popoola P, Oniyangi R, Ogunleye O, et al. Research Advances on the Adverse Effects of Antibiotics on Male Fertility. Afr J Biol Med Res. 2023;6(3):1-28. DOI:10.52589/AJBMRFI8HVFMN
31. Suarez SS. Control of hyperactivation in sperm. Hum Reprod Update. 2008;14(6):647-57.
32. Bebneva TN, Damirov KF. Vospalitel'nye zabolevaniia organov malogo taza. Ginekologiia. 2019;21(5):39-44 (in Russian).
33. Potapov VO. Pelvic inflammatory diseases: clinical aspects of therapy and early rehabilitation of reproductive health. Infusion & Chemotherapy. 2020;(3.2):250-1.
34. Vospalitel'nye bolezni zhenskikh tazovykh organov. Klinicheskie rekomendatsii MZ RF 2024. Rezhim dostupa: https://roag-portal.ru/projects_gynecology. Accessed: 15.08.2024 (in Russian).
35. Yusuf H, Trent M. Management of Pelvic Inflammatory Disease in Clinical Practice. Ther Clin Risk Manag. 2023;19:183-92. DOI:10.2147/TCRM.S350750
36. Ali I, Alfarouk KO, Reshkin SJ, Ibrahim ME. Doxycycline as potential anti-cancer agent. Anticancer Agents Med Chem. 2017;17(12):1617-23. DOI:10.2174/1871520617666170213111951
37. Tu GG, Xu W, Huang H, Li S. Progress in the development of matrix metalloproteinase inhibitors. Curr Med Chem. 2008;15(14):1388-95.
38. Duivenvoorden WC, Popović SV, Lhoták S, et al. Doxycycline decreases tumor burden in a bone metastasis model of human breast cancer. Cancer Res. 2002;62(6):1588-91.
39. Kao GD, Jiang Z, Fernandes AM, et al. Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation. J Biol Chem. 2007;282(29):21206-12. DOI:10.1074/jbc.M703042200

А.С. Аль-Шукри*, М.Р. Коломийцева, С.Б. Петров

ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России, Санкт-Петербург, Россия
*ad330@mail.ru

________________________________________________

Adel S. Al-Shukri*, Mariya R. Kolomijceva, Sergei B. Petrov

Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia
*ad330@mail.ru