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Динамика показателей гемоглобина в периоперационный период у кардиохирургических пациентов при использовании железа карбоксимальтозата
Динамика показателей гемоглобина в периоперационный период у кардиохирургических пациентов при использовании железа карбоксимальтозата
Степин А.В., Екимова Д.М. Динамика показателей гемоглобина в периоперационный период у кардиохирургических пациентов при использовании железа карбоксимальтозата. Consilium Medicum. 2025;27(10):625–630. DOI: 10.26442/20751753.2025.10.203469
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Аннотация
Цель. Изучить динамику гемоглобина (Hb) в периоперационный период при внутривенном использовании железа карбоксимальтозата (ЖКМ) у кардиохирургических пациентов.
Материалы и методы. B ретроспективное исследование включены данные историй болезни 113 кардиохирургических пациентов, которым выполнена инфузия ЖКМ в предоперационный период (1-я группа). Контрольная группа (2-я) подобрана методом псевдорандомизации среди 1042 пациентов, которым инфузию ЖКМ не выполняли. Проведен анализ влияния инфузии ЖКМ на уровень Hb, ферритина, потребность в переливании эритроцитсодержащих компонентов крови, продолжительность послеоперационного периода, летальность и осложнения.
Результаты. После инфузии ЖКМ в 1-й группе концентрация ферритина увеличилась с 37,1±15,4 до 588,3±150,4 мкг/л (p=0,0001). В 1-й группе отмечался значимый рост уровня Hb в течение 24 ч после инфузии ЖКМ, а также в ранний послеоперационный период, во 2-й группе периодов увеличения уровня Hb не отмечено. Снижение уровня Hb в 1-й группе к моменту выписки составило 10,8±11,9 г/л по сравнению с исходным уровнем Hb при поступлении, во 2-й группе – 19,8±12,8 г/л (p<0,001). В послеоперационный период пациентам обеих групп перелито в среднем 0,07±0,3 доз эритроцитсодержащих компонентов крови (p=1,0). Летальных случаев не зафиксировано. Продолжительность лечения в отделении реанимации и общая продолжительность послеоперационного периода в обеих группах достоверно не отличались. Хирургические кровотечения зафиксированы у 4 (3,5%) пациентов 1-й группы и 1 (0,8%) пациента 2-й группы (р=0,35). Частота инфекционных осложнений между группами достоверно не отличалась (p=0,35).
Заключение. Использование однократной инфузии ЖКМ у кардиохирургических пациентов приводит к значимому росту уровня Hb в течение 24 ч после инфузии и в ранний послеоперационный период, не влияя на риск развития инфекционных осложнений и летального исхода.
Ключевые слова: дефицит железа, кардиохирургия, железа карбоксимальтозат, железодефицитная анемия, гемотрансфузии
Materials and methods. The retrospective study included data from the medical charts of 113 cardiac surgical patients who received FCM infusion in the preoperative period (Group 1). The control group (Group 2) was selected using the pseudo-randomization method from 1042 patients who did not receive FCM infusion. We analyzed the effect of FCM infusion on the levels of Hb and ferritin, the need for transfusion of erythrocyte-containing blood components, the duration of the postoperative period, mortality, and complications.
Results. After FCM infusion in Group 1, the ferritin level increased from 37.1±15.4 to 588.3±150.4 µg/L (p=0.0001). In Group 1, there was a significant increase in Hb immediately after FCM infusion, as well as in the early postoperative period; in Group 2, no increase in Hb was observed. The decrease in Hb in Group 1 at the time of discharge was 10.8±11.9 g/L compared to baseline Hb at admission, in Group 2 it was 19.8±12.8 g/L (p<0.001). In the postoperative period, patients of both groups received an average of 0.07±0.3 units of erythrocyte-containing blood components (p=1.0). No deaths were reported. The duration of treatment in the intensive care unit and the total duration of the postoperative period in both groups did not significantly differ. Surgical bleeding was reported in 4 (3.5%) patients in Group 1 and 1 (0.8%) patient in Group 2 (p=0.35). The frequency of infectious complications did not differ significantly between the groups (p=0.35).
Conclusion. A single infusion of FCM in cardiac surgery patients significantly increases Hb levels immediately after the infusion and in the early postoperative period, without affecting the risk of infectious complications and death.
Keywords: iron deficiency, cardiac surgery, iron carboxymaltosate, iron deficiency anemia, blood transfusion
Материалы и методы. B ретроспективное исследование включены данные историй болезни 113 кардиохирургических пациентов, которым выполнена инфузия ЖКМ в предоперационный период (1-я группа). Контрольная группа (2-я) подобрана методом псевдорандомизации среди 1042 пациентов, которым инфузию ЖКМ не выполняли. Проведен анализ влияния инфузии ЖКМ на уровень Hb, ферритина, потребность в переливании эритроцитсодержащих компонентов крови, продолжительность послеоперационного периода, летальность и осложнения.
Результаты. После инфузии ЖКМ в 1-й группе концентрация ферритина увеличилась с 37,1±15,4 до 588,3±150,4 мкг/л (p=0,0001). В 1-й группе отмечался значимый рост уровня Hb в течение 24 ч после инфузии ЖКМ, а также в ранний послеоперационный период, во 2-й группе периодов увеличения уровня Hb не отмечено. Снижение уровня Hb в 1-й группе к моменту выписки составило 10,8±11,9 г/л по сравнению с исходным уровнем Hb при поступлении, во 2-й группе – 19,8±12,8 г/л (p<0,001). В послеоперационный период пациентам обеих групп перелито в среднем 0,07±0,3 доз эритроцитсодержащих компонентов крови (p=1,0). Летальных случаев не зафиксировано. Продолжительность лечения в отделении реанимации и общая продолжительность послеоперационного периода в обеих группах достоверно не отличались. Хирургические кровотечения зафиксированы у 4 (3,5%) пациентов 1-й группы и 1 (0,8%) пациента 2-й группы (р=0,35). Частота инфекционных осложнений между группами достоверно не отличалась (p=0,35).
Заключение. Использование однократной инфузии ЖКМ у кардиохирургических пациентов приводит к значимому росту уровня Hb в течение 24 ч после инфузии и в ранний послеоперационный период, не влияя на риск развития инфекционных осложнений и летального исхода.
Ключевые слова: дефицит железа, кардиохирургия, железа карбоксимальтозат, железодефицитная анемия, гемотрансфузии
________________________________________________
Materials and methods. The retrospective study included data from the medical charts of 113 cardiac surgical patients who received FCM infusion in the preoperative period (Group 1). The control group (Group 2) was selected using the pseudo-randomization method from 1042 patients who did not receive FCM infusion. We analyzed the effect of FCM infusion on the levels of Hb and ferritin, the need for transfusion of erythrocyte-containing blood components, the duration of the postoperative period, mortality, and complications.
Results. After FCM infusion in Group 1, the ferritin level increased from 37.1±15.4 to 588.3±150.4 µg/L (p=0.0001). In Group 1, there was a significant increase in Hb immediately after FCM infusion, as well as in the early postoperative period; in Group 2, no increase in Hb was observed. The decrease in Hb in Group 1 at the time of discharge was 10.8±11.9 g/L compared to baseline Hb at admission, in Group 2 it was 19.8±12.8 g/L (p<0.001). In the postoperative period, patients of both groups received an average of 0.07±0.3 units of erythrocyte-containing blood components (p=1.0). No deaths were reported. The duration of treatment in the intensive care unit and the total duration of the postoperative period in both groups did not significantly differ. Surgical bleeding was reported in 4 (3.5%) patients in Group 1 and 1 (0.8%) patient in Group 2 (p=0.35). The frequency of infectious complications did not differ significantly between the groups (p=0.35).
Conclusion. A single infusion of FCM in cardiac surgery patients significantly increases Hb levels immediately after the infusion and in the early postoperative period, without affecting the risk of infectious complications and death.
Keywords: iron deficiency, cardiac surgery, iron carboxymaltosate, iron deficiency anemia, blood transfusion
Полный текст
Список литературы
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2. Clevenger B, Richards T. Pre-operative anaemia. Anaesthesia. 2015;70 (Suppl. 1):20-8, e6-8. DOI:10.1111/anae.12918
3. Купряшов А.А., Самуилова О.В., Самуилова Д.Ш. Бережное отношение к крови больного как приоритетная стратегия в кардиохирургии. Гематология и трансфузиология. 2021;66(3):395-416 [Kupryashov АА, Samuilova ОV, Samuilova DSh. Optimal blood management as priority route in cardiac surgery. Russian Journal of Hematology and Transfusiology. 2021;66(3):395-416 (in Russian)]. DOI:10.35754/0234-5730-2021-66-3-395-416
4. Юдин Г.В., Рыбка М.М., Хинчагов Д.Я., и др. Анемия как фактор риска дисфункции внутренних органов у больных, оперируемых по поводу приобретенных пороков сердца. Кардиология. 2021;61(4):39-45 [Yudin GV, Rybka MM, Khinchagov DYa, et al. Anemia as a risk factor for organ dysfunctions in patients operated on heart valves. Kardiologiia. 2021;61(4):39-45 (in Russian)]. DOI:10.18087/cardio.2021.4.n1596
5. Калюта Т.Ю., Масляков В.В., Кажекин О.А., Илясова Т.А., Коченкова О.В. Прогностическое значение анемического синдрома у плановых хирургических пациентов (обзор литературы). Актуальные проблемы медицины. 2020;43(1):165-75 [Kalyuta TYu, Maslyakov VV, Kazhekin OA, et al. 2020. Prognostic value of anemic syndrome in surgical patients with elective surgery (review of literature). Challenges in Modern Medicine. 2020;43(1):165-75 (in Russian)].
6. Гарганеева А.А., Тукиш О.В., Кужелева Е.А., и др. Дефицит железа у пациентов кардиохирургического профиля и возможности его коррекции на этапе предоперационной подготовки. Кардиология. 2023;63(7):68-76 [Garganeeva AA, Tukish OV, Kuzheleva EA, et al. Iron deficiency in cardiac surgery patients and the possibility of its correction at the preoperative stage. Kardiologiia. 2023;63(7):68-76 (in Russian)]. DOI:10.18087/cardio.2023.7.n2471
7. Hogan M, Klein AA, Richards T. The impact of anaemia and intravenous iron replacement therapy on outcomes in cardiac surgery. Eur J Cardiothorac Surg. 2014;47(2):218-26. DOI:10.1093/ejcts/ezu200
8. Meybohm P, Westphal S, Ravn HB. Perioperative anemia management as part of PBM in cardiac surgery – A narrative updated review. J Cardiothorac Vasc Anesth. 2020;34(4):1060-73. DOI:10.1053/j.jvca.2019.06.047
9. Gupta S, Panchal P, Gilotra K, et al. Intravenous iron therapy for patients with preoperative iron deficiency or anaemia undergoing cardiac surgery reduces blood transfusions: A systematic review and meta-analysis. Interact Cardiovasc Thorac Surg. 2020;31(2):141-51. DOI:10.1093/icvts/ivaa094
10. Nugara C, Vitale G, Caccamo G, et al. Effect of intravenous iron replacement therapy on exercise capacity in iron deficient anemic patients after cardiac surgery. Monaldi Arch Chest Dis. 2020;90(1). DOI:10.4081/monaldi.2020.1196
11. Spahn DR, Schoenrath F, Spahn GH, et al. Effect of ultra-short-term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: A prospective randomised trial. Lancet. 2019;393(10187):2201-12. DOI:10.1016/S0140-6736(18)32555-8
12. Müller H, Ratschiller T, Schimetta W, et al. Open heart surgery in Jehovah's witnesses: A propensity score analysis. Ann Thorac Surg. 2020;109(2):526-33. DOI:10.1016/j.athoracsur.2019.06.065
13. Richards T, Breymann C, Brookes MJ, et al. Questions and answers on iron deficiency treatment selection and the use of intravenous iron in routine clinical practice. Ann Med. 2021;53(1):274-85. DOI:10.1080/07853890.2020.1867323
14. Lyseng-Williamson KA, Keating GM. Ferric carboxymaltose: A review of its use in iron-deficiency anaemia. Drugs. 2009;69(6):739-56. DOI:10.2165/00003495-200969060-00007
15. Litton E, Xiao J, Ho KM. Safety and efficacy of intravenous iron therapy in reducing requirement for allogeneic blood transfusion: Systematic review and meta-analysis of randomised clinical trials. BMJ. 2013;347:f4822. DOI:10.1136/bmj.f4822
16. Cladellas M, Farré N, Comín-Colet J, et al. Effects of preoperative intravenous erythropoietin plus iron on outcome in anemic patients after cardiac valve replacement. Am J Cardiol. 2012;110(7):1021-6. DOI:10.1016/j.amjcard.2012.05.036
17. Evans CR, Jones R, Phillips G, et al. Observational study of pre-operative intravenous iron given to anaemic patients before elective cardiac surgery. Anaesthesia. 2021;76(5):639-46. DOI:10.1111/anae.15396
18. Klein AA, Chau M, Yeates JA, et al. Preoperative intravenous iron before cardiac surgery: A prospective multicentre feasibility study. Br J Anaesth. 2020;124(3):243-50. DOI:10.1016/j.bja.2019.11.023
19. Padmanabhan H, Siau K, Nevill AM, et al. Intravenous iron does not effectively correct preoperative anaemia in cardiac surgery: A pilot randomized controlled trial. Interact Cardiovasc Thorac Surg. 2019;28(3):447-54. DOI:10.1093/icvts/ivy226
20. Johansson PI, Rasmussen AS, Thomsen LL. Intravenous iron isomaltoside 1000 (Monofer®) reduces postoperative anaemia in preoperatively non-anaemic patients undergoing elective or subacute coronary artery bypass graft, valve replacement or a combination thereof: A randomized double-blind placebo-controlled clinical trial (the PROTECT trial). Vox Sang. 2015;109(3):257-66. DOI:10.1111/vox.12278
21. Task Force on Patient Blood Management for Adult Cardiac Surgery of the European Association for Cardio-Thoracic Surgery (EACTS) and the European Association of Cardiothoracic Anaesthesiology (EACTA); Boer C, Meesters MI, Milojevic M, et al. 2017 EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery. J Cardiothorac Vasc Anesth. 2018;32(1):88-120. DOI:10.1053/j.jvca.2017.06.026
22. Ranucci M, Pavesi M, Pistuddi V, Baryshnikova E. Preoperative anemia correction in cardiac surgery: A propensity-matched study. J Cardiothorac Vasc Anesth. 2021;35(3):874-81. DOI:10.1053/j.jvca.2020.07.015
23. Peters F, Eveslage M, Gallitz I, et al. Post-operative iron carboxymaltose may have an effect on haemoglobin levels in cardiothoracic surgical patients on the ICU – An observational pilot study about anaemia treatment with intravenous iron. Transfus Med Hemother. 2018;45(1):42-6. DOI:10.1159/000481143
24. Auerbach M, Macdougall I. The available intravenous iron formulations: History, efficacy, and toxicology. Hemodial Int. 2017;21(Suppl. 1):S83-92. DOI:10.1111/hdi.12560
2. Clevenger B, Richards T. Pre-operative anaemia. Anaesthesia. 2015;70 (Suppl. 1):20-8, e6-8. DOI:10.1111/anae.12918
3. Kupryashov АА, Samuilova ОV, Samuilova DSh. Optimal blood management as priority route in cardiac surgery. Russian Journal of Hematology and Transfusiology. 2021;66(3):395-416 (in Russian). DOI:10.35754/0234-5730-2021-66-3-395-416
4. Yudin GV, Rybka MM, Khinchagov DYa, et al. Anemia as a risk factor for organ dysfunctions in patients operated on heart valves. Kardiologiia. 2021;61(4):39-45 (in Russian). DOI:10.18087/cardio.2021.4.n1596
5. Kalyuta TYu, Maslyakov VV, Kazhekin OA, et al. 2020. Prognostic value of anemic syndrome in surgical patients with elective surgery (review of literature). Challenges in Modern Medicine. 2020;43(1):165-75 (in Russian).
6. Garganeeva AA, Tukish OV, Kuzheleva EA, et al. Iron deficiency in cardiac surgery patients and the possibility of its correction at the preoperative stage. Kardiologiia. 2023;63(7):68-76 (in Russian). DOI:10.18087/cardio.2023.7.n2471
7. Hogan M, Klein AA, Richards T. The impact of anaemia and intravenous iron replacement therapy on outcomes in cardiac surgery. Eur J Cardiothorac Surg. 2014;47(2):218-26. DOI:10.1093/ejcts/ezu200
8. Meybohm P, Westphal S, Ravn HB. Perioperative anemia management as part of PBM in cardiac surgery – A narrative updated review. J Cardiothorac Vasc Anesth. 2020;34(4):1060-73. DOI:10.1053/j.jvca.2019.06.047
9. Gupta S, Panchal P, Gilotra K, et al. Intravenous iron therapy for patients with preoperative iron deficiency or anaemia undergoing cardiac surgery reduces blood transfusions: A systematic review and meta-analysis. Interact Cardiovasc Thorac Surg. 2020;31(2):141-51. DOI:10.1093/icvts/ivaa094
10. Nugara C, Vitale G, Caccamo G, et al. Effect of intravenous iron replacement therapy on exercise capacity in iron deficient anemic patients after cardiac surgery. Monaldi Arch Chest Dis. 2020;90(1). DOI:10.4081/monaldi.2020.1196
11. Spahn DR, Schoenrath F, Spahn GH, et al. Effect of ultra-short-term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: A prospective randomised trial. Lancet. 2019;393(10187):2201-12. DOI:10.1016/S0140-6736(18)32555-8
12. Müller H, Ratschiller T, Schimetta W, et al. Open heart surgery in Jehovah's witnesses: A propensity score analysis. Ann Thorac Surg. 2020;109(2):526-33. DOI:10.1016/j.athoracsur.2019.06.065
13. Richards T, Breymann C, Brookes MJ, et al. Questions and answers on iron deficiency treatment selection and the use of intravenous iron in routine clinical practice. Ann Med. 2021;53(1):274-85. DOI:10.1080/07853890.2020.1867323
14. Lyseng-Williamson KA, Keating GM. Ferric carboxymaltose: A review of its use in iron-deficiency anaemia. Drugs. 2009;69(6):739-56. DOI:10.2165/00003495-200969060-00007
15. Litton E, Xiao J, Ho KM. Safety and efficacy of intravenous iron therapy in reducing requirement for allogeneic blood transfusion: Systematic review and meta-analysis of randomised clinical trials. BMJ. 2013;347:f4822. DOI:10.1136/bmj.f4822
16. Cladellas M, Farré N, Comín-Colet J, et al. Effects of preoperative intravenous erythropoietin plus iron on outcome in anemic patients after cardiac valve replacement. Am J Cardiol. 2012;110(7):1021-6. DOI:10.1016/j.amjcard.2012.05.036
17. Evans CR, Jones R, Phillips G, et al. Observational study of pre-operative intravenous iron given to anaemic patients before elective cardiac surgery. Anaesthesia. 2021;76(5):639-46. DOI:10.1111/anae.15396
18. Klein AA, Chau M, Yeates JA, et al. Preoperative intravenous iron before cardiac surgery: A prospective multicentre feasibility study. Br J Anaesth. 2020;124(3):243-50. DOI:10.1016/j.bja.2019.11.023
19. Padmanabhan H, Siau K, Nevill AM, et al. Intravenous iron does not effectively correct preoperative anaemia in cardiac surgery: A pilot randomized controlled trial. Interact Cardiovasc Thorac Surg. 2019;28(3):447-54. DOI:10.1093/icvts/ivy226
20. Johansson PI, Rasmussen AS, Thomsen LL. Intravenous iron isomaltoside 1000 (Monofer®) reduces postoperative anaemia in preoperatively non-anaemic patients undergoing elective or subacute coronary artery bypass graft, valve replacement or a combination thereof: A randomized double-blind placebo-controlled clinical trial (the PROTECT trial). Vox Sang. 2015;109(3):257-66. DOI:10.1111/vox.12278
21. Task Force on Patient Blood Management for Adult Cardiac Surgery of the European Association for Cardio-Thoracic Surgery (EACTS) and the European Association of Cardiothoracic Anaesthesiology (EACTA); Boer C, Meesters MI, Milojevic M, et al. 2017 EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery. J Cardiothorac Vasc Anesth. 2018;32(1):88-120. DOI:10.1053/j.jvca.2017.06.026
22. Ranucci M, Pavesi M, Pistuddi V, Baryshnikova E. Preoperative anemia correction in cardiac surgery: A propensity-matched study. J Cardiothorac Vasc Anesth. 2021;35(3):874-81. DOI:10.1053/j.jvca.2020.07.015
23. Peters F, Eveslage M, Gallitz I, et al. Post-operative iron carboxymaltose may have an effect on haemoglobin levels in cardiothoracic surgical patients on the ICU – An observational pilot study about anaemia treatment with intravenous iron. Transfus Med Hemother. 2018;45(1):42-6. DOI:10.1159/000481143
24. Auerbach M, Macdougall I. The available intravenous iron formulations: History, efficacy, and toxicology. Hemodial Int. 2017;21(Suppl. 1):S83-92. DOI:10.1111/hdi.12560
2. Clevenger B, Richards T. Pre-operative anaemia. Anaesthesia. 2015;70 (Suppl. 1):20-8, e6-8. DOI:10.1111/anae.12918
3. Купряшов А.А., Самуилова О.В., Самуилова Д.Ш. Бережное отношение к крови больного как приоритетная стратегия в кардиохирургии. Гематология и трансфузиология. 2021;66(3):395-416 [Kupryashov АА, Samuilova ОV, Samuilova DSh. Optimal blood management as priority route in cardiac surgery. Russian Journal of Hematology and Transfusiology. 2021;66(3):395-416 (in Russian)]. DOI:10.35754/0234-5730-2021-66-3-395-416
4. Юдин Г.В., Рыбка М.М., Хинчагов Д.Я., и др. Анемия как фактор риска дисфункции внутренних органов у больных, оперируемых по поводу приобретенных пороков сердца. Кардиология. 2021;61(4):39-45 [Yudin GV, Rybka MM, Khinchagov DYa, et al. Anemia as a risk factor for organ dysfunctions in patients operated on heart valves. Kardiologiia. 2021;61(4):39-45 (in Russian)]. DOI:10.18087/cardio.2021.4.n1596
5. Калюта Т.Ю., Масляков В.В., Кажекин О.А., Илясова Т.А., Коченкова О.В. Прогностическое значение анемического синдрома у плановых хирургических пациентов (обзор литературы). Актуальные проблемы медицины. 2020;43(1):165-75 [Kalyuta TYu, Maslyakov VV, Kazhekin OA, et al. 2020. Prognostic value of anemic syndrome in surgical patients with elective surgery (review of literature). Challenges in Modern Medicine. 2020;43(1):165-75 (in Russian)].
6. Гарганеева А.А., Тукиш О.В., Кужелева Е.А., и др. Дефицит железа у пациентов кардиохирургического профиля и возможности его коррекции на этапе предоперационной подготовки. Кардиология. 2023;63(7):68-76 [Garganeeva AA, Tukish OV, Kuzheleva EA, et al. Iron deficiency in cardiac surgery patients and the possibility of its correction at the preoperative stage. Kardiologiia. 2023;63(7):68-76 (in Russian)]. DOI:10.18087/cardio.2023.7.n2471
7. Hogan M, Klein AA, Richards T. The impact of anaemia and intravenous iron replacement therapy on outcomes in cardiac surgery. Eur J Cardiothorac Surg. 2014;47(2):218-26. DOI:10.1093/ejcts/ezu200
8. Meybohm P, Westphal S, Ravn HB. Perioperative anemia management as part of PBM in cardiac surgery – A narrative updated review. J Cardiothorac Vasc Anesth. 2020;34(4):1060-73. DOI:10.1053/j.jvca.2019.06.047
9. Gupta S, Panchal P, Gilotra K, et al. Intravenous iron therapy for patients with preoperative iron deficiency or anaemia undergoing cardiac surgery reduces blood transfusions: A systematic review and meta-analysis. Interact Cardiovasc Thorac Surg. 2020;31(2):141-51. DOI:10.1093/icvts/ivaa094
10. Nugara C, Vitale G, Caccamo G, et al. Effect of intravenous iron replacement therapy on exercise capacity in iron deficient anemic patients after cardiac surgery. Monaldi Arch Chest Dis. 2020;90(1). DOI:10.4081/monaldi.2020.1196
11. Spahn DR, Schoenrath F, Spahn GH, et al. Effect of ultra-short-term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: A prospective randomised trial. Lancet. 2019;393(10187):2201-12. DOI:10.1016/S0140-6736(18)32555-8
12. Müller H, Ratschiller T, Schimetta W, et al. Open heart surgery in Jehovah's witnesses: A propensity score analysis. Ann Thorac Surg. 2020;109(2):526-33. DOI:10.1016/j.athoracsur.2019.06.065
13. Richards T, Breymann C, Brookes MJ, et al. Questions and answers on iron deficiency treatment selection and the use of intravenous iron in routine clinical practice. Ann Med. 2021;53(1):274-85. DOI:10.1080/07853890.2020.1867323
14. Lyseng-Williamson KA, Keating GM. Ferric carboxymaltose: A review of its use in iron-deficiency anaemia. Drugs. 2009;69(6):739-56. DOI:10.2165/00003495-200969060-00007
15. Litton E, Xiao J, Ho KM. Safety and efficacy of intravenous iron therapy in reducing requirement for allogeneic blood transfusion: Systematic review and meta-analysis of randomised clinical trials. BMJ. 2013;347:f4822. DOI:10.1136/bmj.f4822
16. Cladellas M, Farré N, Comín-Colet J, et al. Effects of preoperative intravenous erythropoietin plus iron on outcome in anemic patients after cardiac valve replacement. Am J Cardiol. 2012;110(7):1021-6. DOI:10.1016/j.amjcard.2012.05.036
17. Evans CR, Jones R, Phillips G, et al. Observational study of pre-operative intravenous iron given to anaemic patients before elective cardiac surgery. Anaesthesia. 2021;76(5):639-46. DOI:10.1111/anae.15396
18. Klein AA, Chau M, Yeates JA, et al. Preoperative intravenous iron before cardiac surgery: A prospective multicentre feasibility study. Br J Anaesth. 2020;124(3):243-50. DOI:10.1016/j.bja.2019.11.023
19. Padmanabhan H, Siau K, Nevill AM, et al. Intravenous iron does not effectively correct preoperative anaemia in cardiac surgery: A pilot randomized controlled trial. Interact Cardiovasc Thorac Surg. 2019;28(3):447-54. DOI:10.1093/icvts/ivy226
20. Johansson PI, Rasmussen AS, Thomsen LL. Intravenous iron isomaltoside 1000 (Monofer®) reduces postoperative anaemia in preoperatively non-anaemic patients undergoing elective or subacute coronary artery bypass graft, valve replacement or a combination thereof: A randomized double-blind placebo-controlled clinical trial (the PROTECT trial). Vox Sang. 2015;109(3):257-66. DOI:10.1111/vox.12278
21. Task Force on Patient Blood Management for Adult Cardiac Surgery of the European Association for Cardio-Thoracic Surgery (EACTS) and the European Association of Cardiothoracic Anaesthesiology (EACTA); Boer C, Meesters MI, Milojevic M, et al. 2017 EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery. J Cardiothorac Vasc Anesth. 2018;32(1):88-120. DOI:10.1053/j.jvca.2017.06.026
22. Ranucci M, Pavesi M, Pistuddi V, Baryshnikova E. Preoperative anemia correction in cardiac surgery: A propensity-matched study. J Cardiothorac Vasc Anesth. 2021;35(3):874-81. DOI:10.1053/j.jvca.2020.07.015
23. Peters F, Eveslage M, Gallitz I, et al. Post-operative iron carboxymaltose may have an effect on haemoglobin levels in cardiothoracic surgical patients on the ICU – An observational pilot study about anaemia treatment with intravenous iron. Transfus Med Hemother. 2018;45(1):42-6. DOI:10.1159/000481143
24. Auerbach M, Macdougall I. The available intravenous iron formulations: History, efficacy, and toxicology. Hemodial Int. 2017;21(Suppl. 1):S83-92. DOI:10.1111/hdi.12560
________________________________________________
2. Clevenger B, Richards T. Pre-operative anaemia. Anaesthesia. 2015;70 (Suppl. 1):20-8, e6-8. DOI:10.1111/anae.12918
3. Kupryashov АА, Samuilova ОV, Samuilova DSh. Optimal blood management as priority route in cardiac surgery. Russian Journal of Hematology and Transfusiology. 2021;66(3):395-416 (in Russian). DOI:10.35754/0234-5730-2021-66-3-395-416
4. Yudin GV, Rybka MM, Khinchagov DYa, et al. Anemia as a risk factor for organ dysfunctions in patients operated on heart valves. Kardiologiia. 2021;61(4):39-45 (in Russian). DOI:10.18087/cardio.2021.4.n1596
5. Kalyuta TYu, Maslyakov VV, Kazhekin OA, et al. 2020. Prognostic value of anemic syndrome in surgical patients with elective surgery (review of literature). Challenges in Modern Medicine. 2020;43(1):165-75 (in Russian).
6. Garganeeva AA, Tukish OV, Kuzheleva EA, et al. Iron deficiency in cardiac surgery patients and the possibility of its correction at the preoperative stage. Kardiologiia. 2023;63(7):68-76 (in Russian). DOI:10.18087/cardio.2023.7.n2471
7. Hogan M, Klein AA, Richards T. The impact of anaemia and intravenous iron replacement therapy on outcomes in cardiac surgery. Eur J Cardiothorac Surg. 2014;47(2):218-26. DOI:10.1093/ejcts/ezu200
8. Meybohm P, Westphal S, Ravn HB. Perioperative anemia management as part of PBM in cardiac surgery – A narrative updated review. J Cardiothorac Vasc Anesth. 2020;34(4):1060-73. DOI:10.1053/j.jvca.2019.06.047
9. Gupta S, Panchal P, Gilotra K, et al. Intravenous iron therapy for patients with preoperative iron deficiency or anaemia undergoing cardiac surgery reduces blood transfusions: A systematic review and meta-analysis. Interact Cardiovasc Thorac Surg. 2020;31(2):141-51. DOI:10.1093/icvts/ivaa094
10. Nugara C, Vitale G, Caccamo G, et al. Effect of intravenous iron replacement therapy on exercise capacity in iron deficient anemic patients after cardiac surgery. Monaldi Arch Chest Dis. 2020;90(1). DOI:10.4081/monaldi.2020.1196
11. Spahn DR, Schoenrath F, Spahn GH, et al. Effect of ultra-short-term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: A prospective randomised trial. Lancet. 2019;393(10187):2201-12. DOI:10.1016/S0140-6736(18)32555-8
12. Müller H, Ratschiller T, Schimetta W, et al. Open heart surgery in Jehovah's witnesses: A propensity score analysis. Ann Thorac Surg. 2020;109(2):526-33. DOI:10.1016/j.athoracsur.2019.06.065
13. Richards T, Breymann C, Brookes MJ, et al. Questions and answers on iron deficiency treatment selection and the use of intravenous iron in routine clinical practice. Ann Med. 2021;53(1):274-85. DOI:10.1080/07853890.2020.1867323
14. Lyseng-Williamson KA, Keating GM. Ferric carboxymaltose: A review of its use in iron-deficiency anaemia. Drugs. 2009;69(6):739-56. DOI:10.2165/00003495-200969060-00007
15. Litton E, Xiao J, Ho KM. Safety and efficacy of intravenous iron therapy in reducing requirement for allogeneic blood transfusion: Systematic review and meta-analysis of randomised clinical trials. BMJ. 2013;347:f4822. DOI:10.1136/bmj.f4822
16. Cladellas M, Farré N, Comín-Colet J, et al. Effects of preoperative intravenous erythropoietin plus iron on outcome in anemic patients after cardiac valve replacement. Am J Cardiol. 2012;110(7):1021-6. DOI:10.1016/j.amjcard.2012.05.036
17. Evans CR, Jones R, Phillips G, et al. Observational study of pre-operative intravenous iron given to anaemic patients before elective cardiac surgery. Anaesthesia. 2021;76(5):639-46. DOI:10.1111/anae.15396
18. Klein AA, Chau M, Yeates JA, et al. Preoperative intravenous iron before cardiac surgery: A prospective multicentre feasibility study. Br J Anaesth. 2020;124(3):243-50. DOI:10.1016/j.bja.2019.11.023
19. Padmanabhan H, Siau K, Nevill AM, et al. Intravenous iron does not effectively correct preoperative anaemia in cardiac surgery: A pilot randomized controlled trial. Interact Cardiovasc Thorac Surg. 2019;28(3):447-54. DOI:10.1093/icvts/ivy226
20. Johansson PI, Rasmussen AS, Thomsen LL. Intravenous iron isomaltoside 1000 (Monofer®) reduces postoperative anaemia in preoperatively non-anaemic patients undergoing elective or subacute coronary artery bypass graft, valve replacement or a combination thereof: A randomized double-blind placebo-controlled clinical trial (the PROTECT trial). Vox Sang. 2015;109(3):257-66. DOI:10.1111/vox.12278
21. Task Force on Patient Blood Management for Adult Cardiac Surgery of the European Association for Cardio-Thoracic Surgery (EACTS) and the European Association of Cardiothoracic Anaesthesiology (EACTA); Boer C, Meesters MI, Milojevic M, et al. 2017 EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery. J Cardiothorac Vasc Anesth. 2018;32(1):88-120. DOI:10.1053/j.jvca.2017.06.026
22. Ranucci M, Pavesi M, Pistuddi V, Baryshnikova E. Preoperative anemia correction in cardiac surgery: A propensity-matched study. J Cardiothorac Vasc Anesth. 2021;35(3):874-81. DOI:10.1053/j.jvca.2020.07.015
23. Peters F, Eveslage M, Gallitz I, et al. Post-operative iron carboxymaltose may have an effect on haemoglobin levels in cardiothoracic surgical patients on the ICU – An observational pilot study about anaemia treatment with intravenous iron. Transfus Med Hemother. 2018;45(1):42-6. DOI:10.1159/000481143
24. Auerbach M, Macdougall I. The available intravenous iron formulations: History, efficacy, and toxicology. Hemodial Int. 2017;21(Suppl. 1):S83-92. DOI:10.1111/hdi.12560
Авторы
А.В. Степин*1, Д.М. Екимова2
1ГБУЗ СО «Научно-практический центр специализированных видов медицинской помощи "Уральский институт кардиологии"», Екатеринбург, Россия;
2ФГБОУ ВО «Уральский государственный медицинский университет» Минздрава России, Екатеринбург, Россия
*arstepin@me.com
1Ural Institute of Cardiology, Yekaterinburg, Russia;
2Ural State Medical University, Yekaterinburg, Russia
*arstepin@me.com
1ГБУЗ СО «Научно-практический центр специализированных видов медицинской помощи "Уральский институт кардиологии"», Екатеринбург, Россия;
2ФГБОУ ВО «Уральский государственный медицинский университет» Минздрава России, Екатеринбург, Россия
*arstepin@me.com
________________________________________________
1Ural Institute of Cardiology, Yekaterinburg, Russia;
2Ural State Medical University, Yekaterinburg, Russia
*arstepin@me.com
Цель портала OmniDoctor – предоставление профессиональной информации врачам, провизорам и фармацевтам.