Применение комплекса аминокислот, холина и витаминов группы B для улучшения ранней стадии стеатозного заболевания печени, сопряженного с метаболической дисфункцией

Murane N, Sprudza KL, Ivanova J, Zalizko P. Применение комплекса аминокислот, холина и витаминов группы B для улучшения ранней стадии стеатозного заболевания печени, сопряженного с метаболической дисфункцией. Consilium Medicum. 2025;27(12):784–793. DOI: 10.26442/20751753.2025.12.203494

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Murane N, Sprudza KL, Ivanova J, Zalizko P. Complex of amino acids, choline, and B-group vitamins for the improvement of early-stage metabolic dysfunction-associated steatotic liver disease (Translation to Russian). Consilium Medicum. 2025;27(12):784–793. DOI: 10.26442/20751753.2025.12.203494

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Аннотация

Метаболически ассоциированная жировая болезнь печени (МАЖБП) стала наиболее распространенной причиной хронических заболеваний печени во всем мире, затронув, по оценкам, 25% населения планеты. До 80% случаев МАЖБП развиваются бессимптомно и могут не сопровождаться биохимическими отклонениями. Это значит, что МАЖБП часто протекает незаметно до появления осложнений, что затрудняет ее раннюю диагностику. Изменение образа жизни, включая изменение рациона питания, регулярную физическую активность и устойчивое снижение веса, – основа лечения МАЖБП. Однако в настоящее время во всем мире все еще не существует универсальной стандартизированной фармакологической терапии МАЖБП, и лечение по-прежнему основывается в первую очередь на изменении образа жизни. Ожидается, что аминокислоты и комплекс витаминов группы B будут эффективны при лечении ранних стадий стеатогепатоза и стеатогепатита, снижая уровень аминотрансфераз и уменьшая накопление жировых клеток в печени.

Данная статья публикуется в журнале Consilium Medicum на русском языке с разрешения правообладателей. Исходная статья: Murane N, Sprudza KL, Ivanova J, Zalizko P. Complex of Amino Acids, Choline, and B-Group Vitamins for the Improvement of Early-Stage Metabolic Dysfunction-Associated Steatotic Liver Disease. Health. 2025;17:1252-71. DOI: 10.4236/health.2025.1710083 распространяется на условиях лицензии CC BY 4.0.

Ключевые слова: МАЖБП, МАСП, аминокислоты, витамины группы B

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Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most common cause of chronic liver disease worldwide, affecting an estimated 25% of the global population. Up to 80% of individuals with hepatic steatosis remain asymptomatic and may show no biochemical abnormalities, meaning that MASLD is frequently silent until complications occur, which makes early diagnosis challenging. Lifestyle modification, including dietary changes, regular physical activity, and sustained weight reduction, is the cornerstone of MASLD management. At present, however, there is still no universally standardized pharmacological treatment for MASLD all over the world, and management continues to rely primarily on lifestyle modification. The amino acids and B-group vitamin complex is expected to be effective in treating the early stage of steatohepatosis and steatohepatitis, reducing aminotransferases levels and decreasing liver fat cell accumulation.

This article is published in the journal Consilium Medicum in Russian with the permission of the copyright holders. The original article: Murane N, Sprudza KL, Ivanova J, Zalizko P. Complex of Amino Acids, Choline, and B-Group Vitamins for the Improvement of Early-Stage Metabolic Dysfunction-Associated Steatotic Liver Disease. Health. 2025;17:1252-71. DOI: 10.4236/health.2025.1710083 is distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0).

Keywords: MASLD, MASH, amino acids, B-group vitamins

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Авторы

Natalija Murane¹, Klinta Luize Sprudza², Jelena Ivanova^2,3, Polina Zalizko*^1–3

¹Университет Латвии, Рига, Латвия
²Рижский университет им. Паула Страдыня, Рига, Латвия
³Клиника «Оливия», Рига, Латвия
*polina.zalizko@lu.lv

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Natalija Murane¹, Klinta Luize Sprudza², Jelena Ivanova^2,3, Polina Zalizko*^1–3

¹University of Latvia, Riga, Latvia
²Riga Stradins University, Riga, Latvia
³Olivia Clinic, Riga, Latvia
*polina.zalizko@lu.lv

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