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К вопросу об адъювантной терапии инфекции Нelicobacter pylori: фокус на пробиотики и пребиотики
К вопросу об адъювантной терапии инфекции Нelicobacter pylori: фокус на пробиотики и пребиотики
Барышникова Н.В., Ильина А.С., Успенский Ю.П., Суворов А.Н., Ермоленко Е.И. К вопросу об адъювантной терапии инфекции Нelicobacter pylori: фокус на пробиотики и пребиотики. Consilium Medicum. 2025;27(5):268–273. DOI: 10.26442/20751753.2025.5.203276
© ООО «КОНСИЛИУМ МЕДИКУМ», 2025 г.
© ООО «КОНСИЛИУМ МЕДИКУМ», 2025 г.
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Аннотация
Рассмотренные в статье аспекты использования различных вариантов адъювантной терапии инфекции Helicbacter pylori имеют важное прикладное значение и обеспечивают оптимизацию ведения пациентов, инфицированных этим микроорганизмом. Для пациентов с эрозивно-язвенными повреждениями слизистой оболочки желудка препаратом выбора может стать висмута трикалия дицитрат, для пациентов с хроническим атрофическим гастритом обеспечить локальную цитопротекцию и регресс атрофии поможет альфа-глутамил-триптофан, для восстановления эпителиальной проницаемости может быть эффективен ребамипид, а пробиотики и пребиотики обеспечивают как повышение эффективности эрадикации возбудителя, так и уменьшение побочных эффектов и улучшение самочувствия пациентов с помощью коррекции нарушений микробиоты желудочно-кишечного тракта, баланс которой определяет здоровье человека. Важно подобрать оптимальный пробиотик / симбиотик / аутопробиотический штамм / комбинацию нескольких индигенных штаммов для каждого пациента с целью достижения наилучшего результата в эффективности и безопасности эрадикации.
Ключевые слова: Helicobacter pylori, висмута трикалия дицитрат, ребамипид, альфа-глутамил-триптофан, пробиотики, пребиотики, аутопробиотики, эрадикация, микробиота, кишка, иммунитет
Keywords: Helicobacter pylori, bismuth tripotassium dicitrate, rebamipide, alpha-glutamyl-tryptophan, probiotic, prebiotic, autoprobiotic, eradication, microbiota, gut, immunity
Ключевые слова: Helicobacter pylori, висмута трикалия дицитрат, ребамипид, альфа-глутамил-триптофан, пробиотики, пребиотики, аутопробиотики, эрадикация, микробиота, кишка, иммунитет
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Keywords: Helicobacter pylori, bismuth tripotassium dicitrate, rebamipide, alpha-glutamyl-tryptophan, probiotic, prebiotic, autoprobiotic, eradication, microbiota, gut, immunity
Полный текст
Список литературы
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2. Ивашкин В.Т., Маев И.В., Лапина Т.Л., и др. Клинические рекомендации Российской гастроэнтерологической ассоциации и ассоциации «Эндоскопическое общество РЭНДО» по диагностике и лечению гастрита, дуоденита. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2021;31(4):70-99 [Ivashkin VT, Maev IV, Lapina TL, et al. Clinical Recommendations of Russian Gastroenterological Association and RENDO Endoscopic Society on Diagnosis and Treatment of Gastritis and Duodenitis. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2021;31(4):70-99 (in Russian)]. DOI:10.22416/1382-4376-2021-31-4-70-99
3. Осипенко М.Ф., Бикбулатова Е.А., Шакалите Ю.Д., и др. Резистентность Helicobacter pylori к кларитромицину в Новосибирске. Экспериментальная и клиническая гастроэнтерология. 2012;8:15-7 [Osipenko MF, Bikbulatova EA, Shakalite YuD, et al. Resistance of Helicobacter pylori to clarithromycin in Novosibirsk. Experimental and Clinical Gastroenterology. 2012;8:15-7 (in Russian)]. EDN: SEPVAB
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6. Sun Q, Liang X, Zheng Q, et al. High efficacy of 14-day triple therapy-based, bismuth-containing quadruple therapy for initial Helicobacter pylori eradication. Helicobacter. 2010;15(3):233-8. DOI:10.1111/j.1523-5378.2010.00758.x
7. Malfertheiner P. Infection: Bismuth improves PPI-based triple therapy for H. pylori eradication. Nat Rev Gastroenterol Hepatol. 2010;7(10):538-9. DOI:10.1038/nrgastro.2010.131
8. McNicholl AG, Bordin DS, Lucendo A, et al. Combination of Bismuth and Standard Triple Therapy Eradicates Helicobacter pylori Infection in More than 90% of Patients. Clin Gastroenterol Hepatol. 2020;18(1):89-98. DOI:10.1016/j.cgh.2019.03.048
9. Ткаченко Е.И., Успенский Ю.П., Барышникова Н.В. Оптимизация лечения больных с заболеваниями, ассоциированными с инфекцией Helicobacter pylori: обоснование необходимости использования препаратов висмута. Экспериментальная и клиническая гастроэнтерология. 2009;6:116-21 [Tkachenko EI, Uspenskii YuP, Baryshnikova NV. Optimization of treatment of patients with diseases associated with Helicobacter pylori infection: justification of the need to use bismuth preparations. Experimental and Clinical Gastroenterology. 2009;6:116-21 (in Russian)]. EDN: YQIDJV
10. Marshall BJ, Goodwin CS, Warren JR, et al. Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Lancet. 1988;2(8626-7):1437-42. DOI:10.1016/s0140-6736(88)90929-4
11. Лазебник Л.Б., Васильев Ю.В., Щербаков П.Л., и др. Helicobacter pylori: распространенность, диагностика, лечение. Экспериментальная и клиническая гастроэнтерология. 2010;(2):3-7 [Lazebnik LB, Vasilev YuV, Shcherbakov PL, et al. Helicobacter pylori: prevalence, diagnosis, treatment. Experimental and Clinical Gastroenterology. 2010;(2):3-7 (in Russian)]. EDN: MVAIIF
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13. Bagchi D, McGinn TR, Ye X, et al. Mechanism of gastroprotection by bismuth subsalicylate against chemically induced oxidative stress in cultured human gastric mucosal cells. Dig Dis Sci. 1999;44(12):2419-28. DOI:10.1023/a:1026618501729
14. Naito Y, Yoshikawa T. Rebamipide: a gastrointestinal protective drug with pleiotropic activities. Expert Rev Gastroenterol Hepatol. 2010;4(3):261-70. DOI:10.1586/egh.10.25
15. Haruma K, Ito M. Review article: clinical significance of mucosal-protective agents: acid, inflammation, carcinogenesis and rebamipide. Aliment Pharmacol Ther. 2003;18(Suppl. 1):153-9. DOI:10.1046/j.1365-2036.18.s1.17.x
16. Hayashi S, Sugiyama T, Amano K, et al. Effect of rebamipide, a novel antiulcer agent, on Helicobacter pylori adhesion to gastric epithelial cells. Antimicrob Agents Chemother. 1998;42(8):1895-9. DOI:10.1128/AAC.42.8.1895
17. Andreev DN, Maev IV, Dicheva DT. Efficiency of the Inclusion of Rebamipide in the Eradication Therapy for Helicobacter pylori Infection: Meta-Analysis of Randomized Controlled Studies. J Clin Med. 2019;8(9):1498. DOI:10.3390/jcm8091498
18. Hayashi S, Sugiyama T, Yokota K, et al. Combined effect of rebamipide and ecabet sodium on Helicobacter pylori adhesion to gastric epithelial cells. Microbiol Immunol. 2000;44(7):557-62. DOI:10.1111/j.1348-0421.2000.tb02534.x
19. Arakawa T, Higuchi K, Fujiwara Y, et al. 15th anniversary of rebamipide: looking ahead to the new mechanisms and new applications. Dig Dis Sci. 2005;50(Suppl. 1):S3-S11. DOI:10.1007/s10620-005-2800-9
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21. Kamada T, Sato M, Tokutomi T, et al. Rebamipide improves chronic inflammation in the lesser curvature of the corpus after Helicobacter pylori eradication: a multicenter study. Biomed Res Int. 2015;2015:865146. DOI:10.1155/2015/865146
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23. Ohashi H, Maruyama T, Higashi-Matsumoto H, et al. A novel binding assay for metabotropic glutamate receptors using [3H] L-quisqualic acid and recombinant receptors. Z Naturforsch C J Biosci. 2002;57(3-4):348-55. DOI:10.1515/znc-2002-3-425
24. Shevtsov MA, Smagina LV, Kudriavtceva TA, et al. Glu-Trp-ONa or its acylated analogue (R-Glu-Trp-ONa) administration enhances the wound healing in the model of chronic skin wounds in rabbits. Drug Des Devel Ther. 2015;9:1717-27. DOI:10.2147/DDDT.S79665
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26. Uspensky Yu P, Baryshnikova NV, Krasnov AA, et al. The effect of Regasthym Gastro on the restoration of acid production in the stomach according to daily pH-metry in patients with chronic atrophic gastritis. Experimental and Clinical Gastroenterology. 2022;198(2):40-7 (in Russian). DOI:10.31146/1682-8658-ecg-198-2-40-47
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28. Baryshnikova NV, Uspensky YuP, Kalinina EYu, et al. The effectiveness of alpha-glutamyl-tryptophan in relieving inflammation in patients with chronic atrophic gastritis associated with Helicobacter pylori. Dokasatelnaya Gastroenterologia. 2022;11(4):15-21 (in Russian). DOI:10.17116/dokgastro20221104115.
29. Tkachenko EI, Uspenskiy YuP, Baryshnikova NV. Optimization of treatment for Helicobacter pylori-associated diseases. Vrach. 2012; 1:36-8 (in Russian).
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31. Malfertheiner P, Megraud F, O'Morain CA, et al. Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. Gut. 2017;66(1):6-30. DOI:10.1136/gutjnl-2016-312288
32. Malfertheiner P, Megraud F, Rokkas T; European Helicobacter and Microbiota Study group. Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report. Gut. 2022;gutjnl-2022-327745. DOI:10.1136/gutjnl-2022-327745
33. Ivashkin VT, Lapina TL, Maev IV, et al. Clinical Practice Guidelines of Russian Gastroenterological Association, Scientific Society for the Clinical Study of Human Microbiome, Russian Society for the Prevention of Non-Communicable Diseases, Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy for Н. pylori Diagnostics and Treatment in Adults. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2022;32(6):72-93 (in Russian). DOI:10.22416/1382-4376-2022-32-6-72-93
34. Lazebnik LB, Dekhnich NN, Sitkin SI, et al. Helicobacter pylori, helicobacteriosis and associated diseases (VIII Moscow Agreements on the diagnosis and treatment of helicobacteriosis in adults and children). A Clinical Guide for Physicians. Experimental and Clinical Gastroenterology. 2024;(12):49-145 (in Russian). DOI:10.31146/1682-8658-ecg-232-12-49-145
35. Szajewska H, Horvath A, Piwowarczyk A. Meta-analysis: the effects of Saccharomyces boulardii supplementation on Helicobacter pylori eradication rates and side effects during treatment. Aliment Pharmacol Ther. 2010;32(9):1069-79. Erratum in: Aliment Pharmacol Ther. 2010;32(11-12):1408. DOI:10.1111/j.1365-2036.2010.04457.x
36. Wang F, Feng J, Chen P, et al. Probiotics in Helicobacter pylori eradication therapy: Systematic review and network meta-analysis. Clin Res Hepatol Gastroenterol. 2017;41(4):466-75. DOI:10.1016/j.clinre.2017.04.004
37. Lü M, Yu S, Deng J, et al. Efficacy of Probiotic Supplementation Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Randomized Controlled Trials. PLoS One. 2016;11(10):e0163743. DOI:10.1371/journal.pone.0163743
38. Zhang MM, Qian W, Qin YY, et al. Probiotics in Helicobacter pylori eradication therapy: a systematic review and meta-analysis. World J Gastroenterol. 2015;21(14):4345-57. DOI:10.3748/wjg.v21.i14.4345
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40. Viazis N, Argyriou K, Kotzampassi K, et al. A Four-Probiotics Regimen Combined with A Standard Helicobacter pylori-Eradication Treatment Reduces Side Effects and Increases Eradication Rates. Nutrients. 2022;14(3):632. DOI:10.3390/nu14030632
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Авторы
Н.В. Барышникова*1–3, А.С. Ильина3,4, Ю.П. Успенский1,2, А.Н. Суворов3, Е.И. Ермоленко3,5
1ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава России, Санкт-Петербург, Россия;
2ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России, Санкт-Петербург, Россия;
3ФГБНУ «Институт экспериментальной медицины» Минобрнауки России, Санкт-Петербург, Россия;
4ФГБУ «Северо-Западный окружной научно-клинический центр им. Л.Г. Соколова» ФМБА России, Санкт-Петербург, Россия;
5ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России, Санкт-Петербург, Россия
*baryshnikova_nv@mail.ru
1Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia;
2Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia;
3Institute of Experimental Medicine, Saint Petersburg, Russia;
4Sokolov North-Western District Scientific and Clinical Center, Saint Petersburg, Russia;
5Mechnikov North-Western State Medical University, Saint Petersburg, Russia
*baryshnikova_nv@mail.ru
1ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава России, Санкт-Петербург, Россия;
2ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России, Санкт-Петербург, Россия;
3ФГБНУ «Институт экспериментальной медицины» Минобрнауки России, Санкт-Петербург, Россия;
4ФГБУ «Северо-Западный окружной научно-клинический центр им. Л.Г. Соколова» ФМБА России, Санкт-Петербург, Россия;
5ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России, Санкт-Петербург, Россия
*baryshnikova_nv@mail.ru
________________________________________________
1Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia;
2Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia;
3Institute of Experimental Medicine, Saint Petersburg, Russia;
4Sokolov North-Western District Scientific and Clinical Center, Saint Petersburg, Russia;
5Mechnikov North-Western State Medical University, Saint Petersburg, Russia
*baryshnikova_nv@mail.ru
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