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Сердечно-сосудистые заболевания в отдаленные сроки после перенесенного злокачественного новообразования
Сердечно-сосудистые заболевания в отдаленные сроки после перенесенного злокачественного новообразования
Полтавская М.Г., Новикова А.И., Безлюдский А.Л. Сердечно-сосудистые заболевания в отдаленные сроки после перенесенного злокачественного новообразования. Consilium Medicum. 2025;27(8):438–445. DOI: 10.26442/20751753.2025.8.203064
© ООО «КОНСИЛИУМ МЕДИКУМ», 2025 г.
© ООО «КОНСИЛИУМ МЕДИКУМ», 2025 г.
________________________________________________
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Аннотация
Представлен обзор литературных данных, посвященных сердечно-сосудистой патологии у пациентов в отдаленные сроки после перенесенного злокачественного новообразования. Особое внимание уделено неблагоприятным последствиям лучевой терапии. Приведены клинические рекомендации по стратификации кардиального риска и мониторингу отдаленных сердечно-сосудистых осложнений противоопухолевой терапии. Описано клиническое наблюдение лучевой патологии сердца.
Ключевые слова: лица, перенесшие злокачественное новообразование, кардиотоксичность, радиационно-ассоциированные заболевания сердца
Keywords: cancer survivors, cardiotoxicity, radiation-associated heart diseases
Ключевые слова: лица, перенесшие злокачественное новообразование, кардиотоксичность, радиационно-ассоциированные заболевания сердца
________________________________________________
Keywords: cancer survivors, cardiotoxicity, radiation-associated heart diseases
Полный текст
Список литературы
1. Zoller B, Ji J, Sundquist J, Sundquist K. Risk of haemorrhagic and ischaemic stroke in patients with cancer: a nationwide follow-up study from Sweden. Eur J Cancer. 2012;48(12):1875-83.
2. Zoller B, Ji J, Sundquist J, Sundquist K. Risk of coronary heart disease in patients with cancer: a nationwide follow-up study from Sweden. Eur J Cancer. 2012;48(1):121-8.
3. Strongman H, Gadd S, Matthews A, et al. Medium and long-term risks of specific cardiovascular diseases in survivors of 20 adult cancers: a population-based cohort study using multiple linked UK electronic health records databases. Lancet. 2019;394(10203):1041-54.
4. Paterson DI, Wiebe N, Cheung WY, et al. Incident Cardiovascular Disease Among Adults With Cancer: A Population-Based Cohort Study. JACC CardioOncol. 2022;4(1):85-94.
5. Zhang F, Wang K, Du P, et al. Risk of stroke in cancer survivors: a meta-analysis of population-based cohort studies. Neurology. 2021;96(4):e513-26.
6. Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454(7203):436-44.
7. Dardiotis E, Aloizou AM, Markoula S, et al. Cancer-associated stroke: pathophysiology, detection and management (Review). Int J Oncol. 2019;54(3):779-96.
8. Muhandiramge J, John R Zalcberg JR, van Londen GJ. Cardiovascular Disease in Adult Cancer Survivors: a Review of Current Evidence, Strategies for Prevention and Management, and Future Directions for Cardio‑oncology. Curr Oncol Rep. 2022;24:1579-92.
9. Stoltzfus KC, Zhang Y, Sturgeon K, et al. Fatal heart disease among cancer patients. Nat Commun. 2020;11(1):2011.
10. Okwuosa TM, Morgans A, Rhee JW, et al. Impact of hormonal therapies for treatment of hormone dependent cancers (breast and prostate) on the cardiovascular system: effects and modifications: a scientific statement from the American Heart Association. Circ Genom Precis Med. 2021;14(3):e000082.
11. Huang R, Zhou Y, Hu S, et al. Radiotherapy exposure in cancer patients and subsequent risk of stroke: a systematic review and meta-analysis. Front Neurol. 2019;10:233.
12. Tichelli A, Bucher C, Rovo A, et al. Premature cardiovascular disease after allogeneic hematopoietic stemcell transplantation. Blood. 2007;110(9):3463-71.
13. Mitchell JD, Cehic DA, Morgia M, et al. Cardiovascular manifestations from therapeutic radiation: a multidisciplinary expert consensus statement from the International Cardio-Oncology Society. JACC Cardio Oncol. 2021;3:360-80
14. Nardin S, Mora E, Varughese FM, et al. Breast Cancer Survivorship, Quality of Life, and Late Toxicities. Front Oncol. 2020;10:864.
15. Van Nimwegen FA, Schaapveld M, Janus CPM, et al. Cardiovascular disease after Hodgkin lymphoma treatment 40-year disease risk. JAMA Intern Med. 2015;175:1007-17.
16. Wei X, Liu HH, Tucker SL, et al. Risk factors for pericardial effusion in inoperable esophageal cancer patients treated with definitive chemoradiation therapy. Int J Radiat Oncol Biol Phys. 2008;70:707-14.
17. Banfill K, Giuliani M, Aznar M, et al. Cardiac toxicity of thoracic radiotherapy: existing evidence and future directions. J Thorac Oncol. 2021;16:216-27.
18. Popit M, Zaletel M, Žvan B, Zaletel LZ. Long-Term Adverse Effects of Neck Radiotherapy in Childhood on the Carotid Arteries in Survivors of Hodgkin Lymphoma. Cancers (Basel). 2023;15(15):3992.
19. Bergom C, Bradley JA, Ng AK, et al. Past, present, and future of radiation-induced cardiotoxicity: refinements in targeting, surveillance, and risk stratification. JACC Cardio Oncol. 2021;3:343-59.
20. Liu LK, Ouyang W, Zhao X, et al. Pathogenesis and prevention of radiation-induced myocardial fibrosis. Asian Pac J Cancer Prev. 2017;18:583-7.
21. Armstrong GT, Joshi VM, Ness KK, et al. Comprehensive echocardiographic detection of treatment-related cardiac dysfunction in adult survivors of childhood cancer: results from the St. Jude Lifetime Cohort Study. J Am Coll Cardiol. 2015;65:2511-22.
22. Constine L, Schwartz R, Savage D, et al. Cardiac function, perfusion, and morbidity in irradiated long-term survivors of Hodgkin’s disease. Int J Radiat Oncol Biol Phys. 1997;39:897-906.
23. Saiki H, Petersen IA, Scott CG, et al. Risk of heart failure with preserved ejection fraction in older women after contemporary radiotherapy for breast cancer. Circulation. 2017;135:1388-96.
24. Plana JC, Thavendiranathan P, Bucciarelli-Ducci C. Multi-Modality Imaging in the Assessment of Cardiovascular Toxicity in the Cancer Patient. J Am Coll Cardiol Img. 2018;11:1173-86.
25. Polomski EAS, Heemelaar JC, Krol ADG, et al Impaired Global Longitudinal Strain Is Associated with Cardiovascular Events in Hodgkin Lymphoma Survivors. Cancers (Basel). 2022;14(9):2329.
26. Pudil R, Mueller C, Cˇelutkiene˙ J, et al. Role of serum biomarkers in cancer patients receiving cardiotoxic cancer therapies: a position statement from the Cardio-Oncology Study Group of the Heart Failure Association and the Cardio-Oncology Council of the European Society of Cardiology. Eur J Heart Fail. 2020;22:1966-83.
27. Vallabhaneni S, Wang Y, Zhang Y, et al. Cardiovascular Magnetic Resonance in Early Detection of Radiation Associated Cardiotoxicity With Chest Radiation. Front Cardiovasc Med. 2022;9:1-7.
28. Machann W, Beer M, Breunig M, et al. Cardiac magnetic resonance imaging fndings in 20-year survivors of mediastinal radiotherapy for Hodgkin’s disease. Int J Radiat Oncol Biol Phys. 2011;79(4):1117-23.
29. Traber J, Krempien R, Schulz-Menger J, von Knobelsdorf-Brenkenhof F. Assessment of acute radiation therapy-related cardiotoxicity by cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2016;18(S1):1-2.
30. Lyon AR, López-Fernández T, Couch LS, et al. 2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS). Eur Heart J. 2022;43(41):4229-361.
31. Sárközy M, Varga Z, Gáspár R. Pathomechanisms and therapeutic opportunities in radiation‑induced heart disease: from bench to bedside. Clinical Research in Cardiology. Clin Res Cardiol. 2021;110(4):507-31.
32. DePasquale EC, Nasir K, Jacoby DL. Outcomes of adults with restrictive cardiomyopathy after heart transplantation. J Heart Lung Transplant. 2012;31(12):1269-75.
33. Hansson G. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352(16):1685-95.
34. Desai MY, Windecker S, Lancellotti P, et al. Prevention, Diagnosis, and Management of Radiation-Associated Cardiac Disease JACC Scientific Expert Panel. J Am Coll Cardiol. 2019;74:905-27.
35. Stewart FA, Seemann I, Hoving S, Russell NS. Understanding radiation‑induced cardiovascular damage and strategies for intervention. Clin Oncol (R Coll Radiol). 2013;25:617‑24.
36. Oeffinger KC, Mertens AC, Sklar CA, et al. Childhood Cancer Survivor Study. Chronic health conditions in adult survivors of childhood cancer. N Engl J Med. 2006;355:1572-82.
37. Fajardo LF. The pathology of ionizing radiation as defined by morphologic patterns. Acta Oncol. 2005;44:13-22.
38. Thakker R, Suthar K, Bhakta P, et al. Percutaneous Coronary Intervention Outcomes in Patients With Prior Thoracic Radiation Therapy: A Systematic Review and Meta-Analysis. Cardiol Res. 2022;13(6):333-8.
39. Bijl JM, Roos MM, van Leeuwen-Segarceanu EM, et al. Assessment of valvular disorders in survivors of Hodgkin’s lymphoma treated by mediastinal radiotherapy +/- chemotherapy. Am J Cardiol. 2016;117(4):691-6.
40. Wethal T, Lund MB, Edvardsen T, et al. Valvular dysfunction and left ventricular changes in Hodgkin’s lymphoma survivors. A longitudinal study. Br J Cancer. 2009;101:575-81.
41. Donnellan E, Griffin BP, Johnston DR, et al. Rate of progression of aortic stenosis and its impact on outcomes in patients with radiation-associated cardiac disease: a matched cohort study. J Am Coll Cardiol Img. 2018;11:1072-80.
42. Donnellan E, Masri A, Johnston DR, et al. Long-term outcomes of patients with mediastinal radiation-associated severe aortic stenosis and subsequent surgical aortic valve replacement: a matched cohort study. J Am Heart Assoc. 2017;6(5):e005396.
43. Zafar MR, Mustafa SF, Miller TW, et al. Outcomes after transcatheter aortic valve replacement in cancer survivors with prior chest radiation therapy: a systematic review and meta-analysis. Cardiooncology. 2020;14(6):8.
44. De Bruin ML, Dorresteijn LD, van’t Veer MB, et al. Increased risk of stroke and transient ischemic attack in 5-year survivors of Hodgkin lymphoma. J Natl Cancer Inst. 2009;101:928-37.
45. van Dijk IW, van der Pal HJ, van Os RM, et al. Risk of Symptomatic Stroke After Radiation Therapy for Childhood Cancer: A Long-Term Follow-Up Cohort Analysis. Int J Radiat Oncol Biol Phys. 2016;96(3):597-605.
46. Jurado JA, Bashir R, Burket MW. Radiation-induced peripheral artery disease. Catheter Cardiovasc Interv. 2008;72:563-8.
47. Murphy ES, Xie H, Merchant TE, et al. Review of cranial radiotherapy-induced vasculopathy. J Neurooncol. 2015;122(3):421-9.
48. Ness KK, Armstrong GT. Screening for cardiac autonomic dysfunction among Hodgkin lymphoma survivors treated with thoracic radiation. J Am Coll Cardiol. 2015;65:584-5.
49. Andratschke N, Maurer J, Molls M, Trott KR. Late radiation-induced heart disease after radiotherapy. Clinical importance, radiobiological mechanisms and strategies of prevention. Radiother Oncol. 2011;100:160-6.
50. Szabó G, Schmack B, Bulut C, et al. Constrictive pericarditis: risks, aetiologies and outcomes after total pericardiectomy: 24 years of experience. Eur J Cardiothorac Surg. 2013;44:1023-8.
51. Lai YH, Chen HHW, Tsai YS. Accelerated coronary calcium burden in breast cancer patients after radiotherapy: a comparison with age and race matched healthy women. Radiat Oncol. 2021;16:210.
52. Koppelmans V, Vernooij MW, BoogerdW, et al. Prevalence of cerebral small-vessel disease in long-term breast cancer survivors exposed to both adjuvant radiotherapy and chemotherapy. J Clin Oncol. 2015;33:588-93.
53. Leerink JM, van der Pal HJH, Kremer LCM, et al. Refining the 10-year prediction of left ventricular systolic dysfunction in longterm survivors of childhood cancer. JACC CardioOncology. 2021;3:62-72.
54. Gatta G, Botta L, Rossi S, et al. Childhood cancer survival in Europe 1999–2007: results of EUROCARE-5 – a populationbased study. Lancet Oncol. 2014;15:35-47.
55. Armenian SH, Armstrong GT, Aune G, et al. Cardiovascular disease in survivors of childhood cancer: insights into epidemiology, pathophysiology, and prevention. J Clin Oncol. 2018;36:2135-44.
56. Kremer LCM, van Dalen EC, Offringa M, Voûte PA. Frequency and risk factors of anthracycline-induced clinical heart failure in children: a systematic review. Ann Oncol. 2002;13:503-5.
57. Armstrong GT, Oeffinger KC, Chen Y, et al. Modifiable risk factors and major cardiac events among adult survivors of childhood cancer. J Clin Oncol. 2013;31:3673-80.
58. van Dalen EC, Mulder RL, Suh E, et al. Coronary artery disease surveillance among childhood, adolescent and young adult cancer survivors: a systematic review and recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group. Eur J Cancer. 2021;156:127-37.
59. Armenian SH, Hudson MM, Mulder RL, et al. Recommendations for cardiomyopathy surveillance for survivors of childhood cancer:a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group. Lancet Oncol. 2015;16:e123-36.
2. Zoller B, Ji J, Sundquist J, Sundquist K. Risk of coronary heart disease in patients with cancer: a nationwide follow-up study from Sweden. Eur J Cancer. 2012;48(1):121-8.
3. Strongman H, Gadd S, Matthews A, et al. Medium and long-term risks of specific cardiovascular diseases in survivors of 20 adult cancers: a population-based cohort study using multiple linked UK electronic health records databases. Lancet. 2019;394(10203):1041-54.
4. Paterson DI, Wiebe N, Cheung WY, et al. Incident Cardiovascular Disease Among Adults With Cancer: A Population-Based Cohort Study. JACC CardioOncol. 2022;4(1):85-94.
5. Zhang F, Wang K, Du P, et al. Risk of stroke in cancer survivors: a meta-analysis of population-based cohort studies. Neurology. 2021;96(4):e513-26.
6. Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454(7203):436-44.
7. Dardiotis E, Aloizou AM, Markoula S, et al. Cancer-associated stroke: pathophysiology, detection and management (Review). Int J Oncol. 2019;54(3):779-96.
8. Muhandiramge J, John R Zalcberg JR, van Londen GJ. Cardiovascular Disease in Adult Cancer Survivors: a Review of Current Evidence, Strategies for Prevention and Management, and Future Directions for Cardio‑oncology. Curr Oncol Rep. 2022;24:1579-92.
9. Stoltzfus KC, Zhang Y, Sturgeon K, et al. Fatal heart disease among cancer patients. Nat Commun. 2020;11(1):2011.
10. Okwuosa TM, Morgans A, Rhee JW, et al. Impact of hormonal therapies for treatment of hormone dependent cancers (breast and prostate) on the cardiovascular system: effects and modifications: a scientific statement from the American Heart Association. Circ Genom Precis Med. 2021;14(3):e000082.
11. Huang R, Zhou Y, Hu S, et al. Radiotherapy exposure in cancer patients and subsequent risk of stroke: a systematic review and meta-analysis. Front Neurol. 2019;10:233.
12. Tichelli A, Bucher C, Rovo A, et al. Premature cardiovascular disease after allogeneic hematopoietic stemcell transplantation. Blood. 2007;110(9):3463-71.
13. Mitchell JD, Cehic DA, Morgia M, et al. Cardiovascular manifestations from therapeutic radiation: a multidisciplinary expert consensus statement from the International Cardio-Oncology Society. JACC Cardio Oncol. 2021;3:360-80
14. Nardin S, Mora E, Varughese FM, et al. Breast Cancer Survivorship, Quality of Life, and Late Toxicities. Front Oncol. 2020;10:864.
15. Van Nimwegen FA, Schaapveld M, Janus CPM, et al. Cardiovascular disease after Hodgkin lymphoma treatment 40-year disease risk. JAMA Intern Med. 2015;175:1007-17.
16. Wei X, Liu HH, Tucker SL, et al. Risk factors for pericardial effusion in inoperable esophageal cancer patients treated with definitive chemoradiation therapy. Int J Radiat Oncol Biol Phys. 2008;70:707-14.
17. Banfill K, Giuliani M, Aznar M, et al. Cardiac toxicity of thoracic radiotherapy: existing evidence and future directions. J Thorac Oncol. 2021;16:216-27.
18. Popit M, Zaletel M, Žvan B, Zaletel LZ. Long-Term Adverse Effects of Neck Radiotherapy in Childhood on the Carotid Arteries in Survivors of Hodgkin Lymphoma. Cancers (Basel). 2023;15(15):3992.
19. Bergom C, Bradley JA, Ng AK, et al. Past, present, and future of radiation-induced cardiotoxicity: refinements in targeting, surveillance, and risk stratification. JACC Cardio Oncol. 2021;3:343-59.
20. Liu LK, Ouyang W, Zhao X, et al. Pathogenesis and prevention of radiation-induced myocardial fibrosis. Asian Pac J Cancer Prev. 2017;18:583-7.
21. Armstrong GT, Joshi VM, Ness KK, et al. Comprehensive echocardiographic detection of treatment-related cardiac dysfunction in adult survivors of childhood cancer: results from the St. Jude Lifetime Cohort Study. J Am Coll Cardiol. 2015;65:2511-22.
22. Constine L, Schwartz R, Savage D, et al. Cardiac function, perfusion, and morbidity in irradiated long-term survivors of Hodgkin’s disease. Int J Radiat Oncol Biol Phys. 1997;39:897-906.
23. Saiki H, Petersen IA, Scott CG, et al. Risk of heart failure with preserved ejection fraction in older women after contemporary radiotherapy for breast cancer. Circulation. 2017;135:1388-96.
24. Plana JC, Thavendiranathan P, Bucciarelli-Ducci C. Multi-Modality Imaging in the Assessment of Cardiovascular Toxicity in the Cancer Patient. J Am Coll Cardiol Img. 2018;11:1173-86.
25. Polomski EAS, Heemelaar JC, Krol ADG, et al Impaired Global Longitudinal Strain Is Associated with Cardiovascular Events in Hodgkin Lymphoma Survivors. Cancers (Basel). 2022;14(9):2329.
26. Pudil R, Mueller C, Cˇelutkiene˙ J, et al. Role of serum biomarkers in cancer patients receiving cardiotoxic cancer therapies: a position statement from the Cardio-Oncology Study Group of the Heart Failure Association and the Cardio-Oncology Council of the European Society of Cardiology. Eur J Heart Fail. 2020;22:1966-83.
27. Vallabhaneni S, Wang Y, Zhang Y, et al. Cardiovascular Magnetic Resonance in Early Detection of Radiation Associated Cardiotoxicity With Chest Radiation. Front Cardiovasc Med. 2022;9:1-7.
28. Machann W, Beer M, Breunig M, et al. Cardiac magnetic resonance imaging fndings in 20-year survivors of mediastinal radiotherapy for Hodgkin’s disease. Int J Radiat Oncol Biol Phys. 2011;79(4):1117-23.
29. Traber J, Krempien R, Schulz-Menger J, von Knobelsdorf-Brenkenhof F. Assessment of acute radiation therapy-related cardiotoxicity by cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2016;18(S1):1-2.
30. Lyon AR, López-Fernández T, Couch LS, et al. 2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS). Eur Heart J. 2022;43(41):4229-361.
31. Sárközy M, Varga Z, Gáspár R. Pathomechanisms and therapeutic opportunities in radiation‑induced heart disease: from bench to bedside. Clinical Research in Cardiology. Clin Res Cardiol. 2021;110(4):507-31.
32. DePasquale EC, Nasir K, Jacoby DL. Outcomes of adults with restrictive cardiomyopathy after heart transplantation. J Heart Lung Transplant. 2012;31(12):1269-75.
33. Hansson G. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352(16):1685-95.
34. Desai MY, Windecker S, Lancellotti P, et al. Prevention, Diagnosis, and Management of Radiation-Associated Cardiac Disease JACC Scientific Expert Panel. J Am Coll Cardiol. 2019;74:905-27.
35. Stewart FA, Seemann I, Hoving S, Russell NS. Understanding radiation‑induced cardiovascular damage and strategies for intervention. Clin Oncol (R Coll Radiol). 2013;25:617‑24.
36. Oeffinger KC, Mertens AC, Sklar CA, et al. Childhood Cancer Survivor Study. Chronic health conditions in adult survivors of childhood cancer. N Engl J Med. 2006;355:1572-82.
37. Fajardo LF. The pathology of ionizing radiation as defined by morphologic patterns. Acta Oncol. 2005;44:13-22.
38. Thakker R, Suthar K, Bhakta P, et al. Percutaneous Coronary Intervention Outcomes in Patients With Prior Thoracic Radiation Therapy: A Systematic Review and Meta-Analysis. Cardiol Res. 2022;13(6):333-8.
39. Bijl JM, Roos MM, van Leeuwen-Segarceanu EM, et al. Assessment of valvular disorders in survivors of Hodgkin’s lymphoma treated by mediastinal radiotherapy +/- chemotherapy. Am J Cardiol. 2016;117(4):691-6.
40. Wethal T, Lund MB, Edvardsen T, et al. Valvular dysfunction and left ventricular changes in Hodgkin’s lymphoma survivors. A longitudinal study. Br J Cancer. 2009;101:575-81.
41. Donnellan E, Griffin BP, Johnston DR, et al. Rate of progression of aortic stenosis and its impact on outcomes in patients with radiation-associated cardiac disease: a matched cohort study. J Am Coll Cardiol Img. 2018;11:1072-80.
42. Donnellan E, Masri A, Johnston DR, et al. Long-term outcomes of patients with mediastinal radiation-associated severe aortic stenosis and subsequent surgical aortic valve replacement: a matched cohort study. J Am Heart Assoc. 2017;6(5):e005396.
43. Zafar MR, Mustafa SF, Miller TW, et al. Outcomes after transcatheter aortic valve replacement in cancer survivors with prior chest radiation therapy: a systematic review and meta-analysis. Cardiooncology. 2020;14(6):8.
44. De Bruin ML, Dorresteijn LD, van’t Veer MB, et al. Increased risk of stroke and transient ischemic attack in 5-year survivors of Hodgkin lymphoma. J Natl Cancer Inst. 2009;101:928-37.
45. van Dijk IW, van der Pal HJ, van Os RM, et al. Risk of Symptomatic Stroke After Radiation Therapy for Childhood Cancer: A Long-Term Follow-Up Cohort Analysis. Int J Radiat Oncol Biol Phys. 2016;96(3):597-605.
46. Jurado JA, Bashir R, Burket MW. Radiation-induced peripheral artery disease. Catheter Cardiovasc Interv. 2008;72:563-8.
47. Murphy ES, Xie H, Merchant TE, et al. Review of cranial radiotherapy-induced vasculopathy. J Neurooncol. 2015;122(3):421-9.
48. Ness KK, Armstrong GT. Screening for cardiac autonomic dysfunction among Hodgkin lymphoma survivors treated with thoracic radiation. J Am Coll Cardiol. 2015;65:584-5.
49. Andratschke N, Maurer J, Molls M, Trott KR. Late radiation-induced heart disease after radiotherapy. Clinical importance, radiobiological mechanisms and strategies of prevention. Radiother Oncol. 2011;100:160-6.
50. Szabó G, Schmack B, Bulut C, et al. Constrictive pericarditis: risks, aetiologies and outcomes after total pericardiectomy: 24 years of experience. Eur J Cardiothorac Surg. 2013;44:1023-8.
51. Lai YH, Chen HHW, Tsai YS. Accelerated coronary calcium burden in breast cancer patients after radiotherapy: a comparison with age and race matched healthy women. Radiat Oncol. 2021;16:210.
52. Koppelmans V, Vernooij MW, BoogerdW, et al. Prevalence of cerebral small-vessel disease in long-term breast cancer survivors exposed to both adjuvant radiotherapy and chemotherapy. J Clin Oncol. 2015;33:588-93.
53. Leerink JM, van der Pal HJH, Kremer LCM, et al. Refining the 10-year prediction of left ventricular systolic dysfunction in longterm survivors of childhood cancer. JACC CardioOncology. 2021;3:62-72.
54. Gatta G, Botta L, Rossi S, et al. Childhood cancer survival in Europe 1999–2007: results of EUROCARE-5 – a populationbased study. Lancet Oncol. 2014;15:35-47.
55. Armenian SH, Armstrong GT, Aune G, et al. Cardiovascular disease in survivors of childhood cancer: insights into epidemiology, pathophysiology, and prevention. J Clin Oncol. 2018;36:2135-44.
56. Kremer LCM, van Dalen EC, Offringa M, Voûte PA. Frequency and risk factors of anthracycline-induced clinical heart failure in children: a systematic review. Ann Oncol. 2002;13:503-5.
57. Armstrong GT, Oeffinger KC, Chen Y, et al. Modifiable risk factors and major cardiac events among adult survivors of childhood cancer. J Clin Oncol. 2013;31:3673-80.
58. van Dalen EC, Mulder RL, Suh E, et al. Coronary artery disease surveillance among childhood, adolescent and young adult cancer survivors: a systematic review and recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group. Eur J Cancer. 2021;156:127-37.
59. Armenian SH, Hudson MM, Mulder RL, et al. Recommendations for cardiomyopathy surveillance for survivors of childhood cancer:a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group. Lancet Oncol. 2015;16:e123-36.
2. Zoller B, Ji J, Sundquist J, Sundquist K. Risk of coronary heart disease in patients with cancer: a nationwide follow-up study from Sweden. Eur J Cancer. 2012;48(1):121-8.
3. Strongman H, Gadd S, Matthews A, et al. Medium and long-term risks of specific cardiovascular diseases in survivors of 20 adult cancers: a population-based cohort study using multiple linked UK electronic health records databases. Lancet. 2019;394(10203):1041-54.
4. Paterson DI, Wiebe N, Cheung WY, et al. Incident Cardiovascular Disease Among Adults With Cancer: A Population-Based Cohort Study. JACC CardioOncol. 2022;4(1):85-94.
5. Zhang F, Wang K, Du P, et al. Risk of stroke in cancer survivors: a meta-analysis of population-based cohort studies. Neurology. 2021;96(4):e513-26.
6. Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454(7203):436-44.
7. Dardiotis E, Aloizou AM, Markoula S, et al. Cancer-associated stroke: pathophysiology, detection and management (Review). Int J Oncol. 2019;54(3):779-96.
8. Muhandiramge J, John R Zalcberg JR, van Londen GJ. Cardiovascular Disease in Adult Cancer Survivors: a Review of Current Evidence, Strategies for Prevention and Management, and Future Directions for Cardio‑oncology. Curr Oncol Rep. 2022;24:1579-92.
9. Stoltzfus KC, Zhang Y, Sturgeon K, et al. Fatal heart disease among cancer patients. Nat Commun. 2020;11(1):2011.
10. Okwuosa TM, Morgans A, Rhee JW, et al. Impact of hormonal therapies for treatment of hormone dependent cancers (breast and prostate) on the cardiovascular system: effects and modifications: a scientific statement from the American Heart Association. Circ Genom Precis Med. 2021;14(3):e000082.
11. Huang R, Zhou Y, Hu S, et al. Radiotherapy exposure in cancer patients and subsequent risk of stroke: a systematic review and meta-analysis. Front Neurol. 2019;10:233.
12. Tichelli A, Bucher C, Rovo A, et al. Premature cardiovascular disease after allogeneic hematopoietic stemcell transplantation. Blood. 2007;110(9):3463-71.
13. Mitchell JD, Cehic DA, Morgia M, et al. Cardiovascular manifestations from therapeutic radiation: a multidisciplinary expert consensus statement from the International Cardio-Oncology Society. JACC Cardio Oncol. 2021;3:360-80
14. Nardin S, Mora E, Varughese FM, et al. Breast Cancer Survivorship, Quality of Life, and Late Toxicities. Front Oncol. 2020;10:864.
15. Van Nimwegen FA, Schaapveld M, Janus CPM, et al. Cardiovascular disease after Hodgkin lymphoma treatment 40-year disease risk. JAMA Intern Med. 2015;175:1007-17.
16. Wei X, Liu HH, Tucker SL, et al. Risk factors for pericardial effusion in inoperable esophageal cancer patients treated with definitive chemoradiation therapy. Int J Radiat Oncol Biol Phys. 2008;70:707-14.
17. Banfill K, Giuliani M, Aznar M, et al. Cardiac toxicity of thoracic radiotherapy: existing evidence and future directions. J Thorac Oncol. 2021;16:216-27.
18. Popit M, Zaletel M, Žvan B, Zaletel LZ. Long-Term Adverse Effects of Neck Radiotherapy in Childhood on the Carotid Arteries in Survivors of Hodgkin Lymphoma. Cancers (Basel). 2023;15(15):3992.
19. Bergom C, Bradley JA, Ng AK, et al. Past, present, and future of radiation-induced cardiotoxicity: refinements in targeting, surveillance, and risk stratification. JACC Cardio Oncol. 2021;3:343-59.
20. Liu LK, Ouyang W, Zhao X, et al. Pathogenesis and prevention of radiation-induced myocardial fibrosis. Asian Pac J Cancer Prev. 2017;18:583-7.
21. Armstrong GT, Joshi VM, Ness KK, et al. Comprehensive echocardiographic detection of treatment-related cardiac dysfunction in adult survivors of childhood cancer: results from the St. Jude Lifetime Cohort Study. J Am Coll Cardiol. 2015;65:2511-22.
22. Constine L, Schwartz R, Savage D, et al. Cardiac function, perfusion, and morbidity in irradiated long-term survivors of Hodgkin’s disease. Int J Radiat Oncol Biol Phys. 1997;39:897-906.
23. Saiki H, Petersen IA, Scott CG, et al. Risk of heart failure with preserved ejection fraction in older women after contemporary radiotherapy for breast cancer. Circulation. 2017;135:1388-96.
24. Plana JC, Thavendiranathan P, Bucciarelli-Ducci C. Multi-Modality Imaging in the Assessment of Cardiovascular Toxicity in the Cancer Patient. J Am Coll Cardiol Img. 2018;11:1173-86.
25. Polomski EAS, Heemelaar JC, Krol ADG, et al Impaired Global Longitudinal Strain Is Associated with Cardiovascular Events in Hodgkin Lymphoma Survivors. Cancers (Basel). 2022;14(9):2329.
26. Pudil R, Mueller C, Cˇelutkiene˙ J, et al. Role of serum biomarkers in cancer patients receiving cardiotoxic cancer therapies: a position statement from the Cardio-Oncology Study Group of the Heart Failure Association and the Cardio-Oncology Council of the European Society of Cardiology. Eur J Heart Fail. 2020;22:1966-83.
27. Vallabhaneni S, Wang Y, Zhang Y, et al. Cardiovascular Magnetic Resonance in Early Detection of Radiation Associated Cardiotoxicity With Chest Radiation. Front Cardiovasc Med. 2022;9:1-7.
28. Machann W, Beer M, Breunig M, et al. Cardiac magnetic resonance imaging fndings in 20-year survivors of mediastinal radiotherapy for Hodgkin’s disease. Int J Radiat Oncol Biol Phys. 2011;79(4):1117-23.
29. Traber J, Krempien R, Schulz-Menger J, von Knobelsdorf-Brenkenhof F. Assessment of acute radiation therapy-related cardiotoxicity by cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2016;18(S1):1-2.
30. Lyon AR, López-Fernández T, Couch LS, et al. 2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS). Eur Heart J. 2022;43(41):4229-361.
31. Sárközy M, Varga Z, Gáspár R. Pathomechanisms and therapeutic opportunities in radiation‑induced heart disease: from bench to bedside. Clinical Research in Cardiology. Clin Res Cardiol. 2021;110(4):507-31.
32. DePasquale EC, Nasir K, Jacoby DL. Outcomes of adults with restrictive cardiomyopathy after heart transplantation. J Heart Lung Transplant. 2012;31(12):1269-75.
33. Hansson G. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352(16):1685-95.
34. Desai MY, Windecker S, Lancellotti P, et al. Prevention, Diagnosis, and Management of Radiation-Associated Cardiac Disease JACC Scientific Expert Panel. J Am Coll Cardiol. 2019;74:905-27.
35. Stewart FA, Seemann I, Hoving S, Russell NS. Understanding radiation‑induced cardiovascular damage and strategies for intervention. Clin Oncol (R Coll Radiol). 2013;25:617‑24.
36. Oeffinger KC, Mertens AC, Sklar CA, et al. Childhood Cancer Survivor Study. Chronic health conditions in adult survivors of childhood cancer. N Engl J Med. 2006;355:1572-82.
37. Fajardo LF. The pathology of ionizing radiation as defined by morphologic patterns. Acta Oncol. 2005;44:13-22.
38. Thakker R, Suthar K, Bhakta P, et al. Percutaneous Coronary Intervention Outcomes in Patients With Prior Thoracic Radiation Therapy: A Systematic Review and Meta-Analysis. Cardiol Res. 2022;13(6):333-8.
39. Bijl JM, Roos MM, van Leeuwen-Segarceanu EM, et al. Assessment of valvular disorders in survivors of Hodgkin’s lymphoma treated by mediastinal radiotherapy +/- chemotherapy. Am J Cardiol. 2016;117(4):691-6.
40. Wethal T, Lund MB, Edvardsen T, et al. Valvular dysfunction and left ventricular changes in Hodgkin’s lymphoma survivors. A longitudinal study. Br J Cancer. 2009;101:575-81.
41. Donnellan E, Griffin BP, Johnston DR, et al. Rate of progression of aortic stenosis and its impact on outcomes in patients with radiation-associated cardiac disease: a matched cohort study. J Am Coll Cardiol Img. 2018;11:1072-80.
42. Donnellan E, Masri A, Johnston DR, et al. Long-term outcomes of patients with mediastinal radiation-associated severe aortic stenosis and subsequent surgical aortic valve replacement: a matched cohort study. J Am Heart Assoc. 2017;6(5):e005396.
43. Zafar MR, Mustafa SF, Miller TW, et al. Outcomes after transcatheter aortic valve replacement in cancer survivors with prior chest radiation therapy: a systematic review and meta-analysis. Cardiooncology. 2020;14(6):8.
44. De Bruin ML, Dorresteijn LD, van’t Veer MB, et al. Increased risk of stroke and transient ischemic attack in 5-year survivors of Hodgkin lymphoma. J Natl Cancer Inst. 2009;101:928-37.
45. van Dijk IW, van der Pal HJ, van Os RM, et al. Risk of Symptomatic Stroke After Radiation Therapy for Childhood Cancer: A Long-Term Follow-Up Cohort Analysis. Int J Radiat Oncol Biol Phys. 2016;96(3):597-605.
46. Jurado JA, Bashir R, Burket MW. Radiation-induced peripheral artery disease. Catheter Cardiovasc Interv. 2008;72:563-8.
47. Murphy ES, Xie H, Merchant TE, et al. Review of cranial radiotherapy-induced vasculopathy. J Neurooncol. 2015;122(3):421-9.
48. Ness KK, Armstrong GT. Screening for cardiac autonomic dysfunction among Hodgkin lymphoma survivors treated with thoracic radiation. J Am Coll Cardiol. 2015;65:584-5.
49. Andratschke N, Maurer J, Molls M, Trott KR. Late radiation-induced heart disease after radiotherapy. Clinical importance, radiobiological mechanisms and strategies of prevention. Radiother Oncol. 2011;100:160-6.
50. Szabó G, Schmack B, Bulut C, et al. Constrictive pericarditis: risks, aetiologies and outcomes after total pericardiectomy: 24 years of experience. Eur J Cardiothorac Surg. 2013;44:1023-8.
51. Lai YH, Chen HHW, Tsai YS. Accelerated coronary calcium burden in breast cancer patients after radiotherapy: a comparison with age and race matched healthy women. Radiat Oncol. 2021;16:210.
52. Koppelmans V, Vernooij MW, BoogerdW, et al. Prevalence of cerebral small-vessel disease in long-term breast cancer survivors exposed to both adjuvant radiotherapy and chemotherapy. J Clin Oncol. 2015;33:588-93.
53. Leerink JM, van der Pal HJH, Kremer LCM, et al. Refining the 10-year prediction of left ventricular systolic dysfunction in longterm survivors of childhood cancer. JACC CardioOncology. 2021;3:62-72.
54. Gatta G, Botta L, Rossi S, et al. Childhood cancer survival in Europe 1999–2007: results of EUROCARE-5 – a populationbased study. Lancet Oncol. 2014;15:35-47.
55. Armenian SH, Armstrong GT, Aune G, et al. Cardiovascular disease in survivors of childhood cancer: insights into epidemiology, pathophysiology, and prevention. J Clin Oncol. 2018;36:2135-44.
56. Kremer LCM, van Dalen EC, Offringa M, Voûte PA. Frequency and risk factors of anthracycline-induced clinical heart failure in children: a systematic review. Ann Oncol. 2002;13:503-5.
57. Armstrong GT, Oeffinger KC, Chen Y, et al. Modifiable risk factors and major cardiac events among adult survivors of childhood cancer. J Clin Oncol. 2013;31:3673-80.
58. van Dalen EC, Mulder RL, Suh E, et al. Coronary artery disease surveillance among childhood, adolescent and young adult cancer survivors: a systematic review and recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group. Eur J Cancer. 2021;156:127-37.
59. Armenian SH, Hudson MM, Mulder RL, et al. Recommendations for cardiomyopathy surveillance for survivors of childhood cancer:a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group. Lancet Oncol. 2015;16:e123-36.
________________________________________________
2. Zoller B, Ji J, Sundquist J, Sundquist K. Risk of coronary heart disease in patients with cancer: a nationwide follow-up study from Sweden. Eur J Cancer. 2012;48(1):121-8.
3. Strongman H, Gadd S, Matthews A, et al. Medium and long-term risks of specific cardiovascular diseases in survivors of 20 adult cancers: a population-based cohort study using multiple linked UK electronic health records databases. Lancet. 2019;394(10203):1041-54.
4. Paterson DI, Wiebe N, Cheung WY, et al. Incident Cardiovascular Disease Among Adults With Cancer: A Population-Based Cohort Study. JACC CardioOncol. 2022;4(1):85-94.
5. Zhang F, Wang K, Du P, et al. Risk of stroke in cancer survivors: a meta-analysis of population-based cohort studies. Neurology. 2021;96(4):e513-26.
6. Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454(7203):436-44.
7. Dardiotis E, Aloizou AM, Markoula S, et al. Cancer-associated stroke: pathophysiology, detection and management (Review). Int J Oncol. 2019;54(3):779-96.
8. Muhandiramge J, John R Zalcberg JR, van Londen GJ. Cardiovascular Disease in Adult Cancer Survivors: a Review of Current Evidence, Strategies for Prevention and Management, and Future Directions for Cardio‑oncology. Curr Oncol Rep. 2022;24:1579-92.
9. Stoltzfus KC, Zhang Y, Sturgeon K, et al. Fatal heart disease among cancer patients. Nat Commun. 2020;11(1):2011.
10. Okwuosa TM, Morgans A, Rhee JW, et al. Impact of hormonal therapies for treatment of hormone dependent cancers (breast and prostate) on the cardiovascular system: effects and modifications: a scientific statement from the American Heart Association. Circ Genom Precis Med. 2021;14(3):e000082.
11. Huang R, Zhou Y, Hu S, et al. Radiotherapy exposure in cancer patients and subsequent risk of stroke: a systematic review and meta-analysis. Front Neurol. 2019;10:233.
12. Tichelli A, Bucher C, Rovo A, et al. Premature cardiovascular disease after allogeneic hematopoietic stemcell transplantation. Blood. 2007;110(9):3463-71.
13. Mitchell JD, Cehic DA, Morgia M, et al. Cardiovascular manifestations from therapeutic radiation: a multidisciplinary expert consensus statement from the International Cardio-Oncology Society. JACC Cardio Oncol. 2021;3:360-80
14. Nardin S, Mora E, Varughese FM, et al. Breast Cancer Survivorship, Quality of Life, and Late Toxicities. Front Oncol. 2020;10:864.
15. Van Nimwegen FA, Schaapveld M, Janus CPM, et al. Cardiovascular disease after Hodgkin lymphoma treatment 40-year disease risk. JAMA Intern Med. 2015;175:1007-17.
16. Wei X, Liu HH, Tucker SL, et al. Risk factors for pericardial effusion in inoperable esophageal cancer patients treated with definitive chemoradiation therapy. Int J Radiat Oncol Biol Phys. 2008;70:707-14.
17. Banfill K, Giuliani M, Aznar M, et al. Cardiac toxicity of thoracic radiotherapy: existing evidence and future directions. J Thorac Oncol. 2021;16:216-27.
18. Popit M, Zaletel M, Žvan B, Zaletel LZ. Long-Term Adverse Effects of Neck Radiotherapy in Childhood on the Carotid Arteries in Survivors of Hodgkin Lymphoma. Cancers (Basel). 2023;15(15):3992.
19. Bergom C, Bradley JA, Ng AK, et al. Past, present, and future of radiation-induced cardiotoxicity: refinements in targeting, surveillance, and risk stratification. JACC Cardio Oncol. 2021;3:343-59.
20. Liu LK, Ouyang W, Zhao X, et al. Pathogenesis and prevention of radiation-induced myocardial fibrosis. Asian Pac J Cancer Prev. 2017;18:583-7.
21. Armstrong GT, Joshi VM, Ness KK, et al. Comprehensive echocardiographic detection of treatment-related cardiac dysfunction in adult survivors of childhood cancer: results from the St. Jude Lifetime Cohort Study. J Am Coll Cardiol. 2015;65:2511-22.
22. Constine L, Schwartz R, Savage D, et al. Cardiac function, perfusion, and morbidity in irradiated long-term survivors of Hodgkin’s disease. Int J Radiat Oncol Biol Phys. 1997;39:897-906.
23. Saiki H, Petersen IA, Scott CG, et al. Risk of heart failure with preserved ejection fraction in older women after contemporary radiotherapy for breast cancer. Circulation. 2017;135:1388-96.
24. Plana JC, Thavendiranathan P, Bucciarelli-Ducci C. Multi-Modality Imaging in the Assessment of Cardiovascular Toxicity in the Cancer Patient. J Am Coll Cardiol Img. 2018;11:1173-86.
25. Polomski EAS, Heemelaar JC, Krol ADG, et al Impaired Global Longitudinal Strain Is Associated with Cardiovascular Events in Hodgkin Lymphoma Survivors. Cancers (Basel). 2022;14(9):2329.
26. Pudil R, Mueller C, Cˇelutkiene˙ J, et al. Role of serum biomarkers in cancer patients receiving cardiotoxic cancer therapies: a position statement from the Cardio-Oncology Study Group of the Heart Failure Association and the Cardio-Oncology Council of the European Society of Cardiology. Eur J Heart Fail. 2020;22:1966-83.
27. Vallabhaneni S, Wang Y, Zhang Y, et al. Cardiovascular Magnetic Resonance in Early Detection of Radiation Associated Cardiotoxicity With Chest Radiation. Front Cardiovasc Med. 2022;9:1-7.
28. Machann W, Beer M, Breunig M, et al. Cardiac magnetic resonance imaging fndings in 20-year survivors of mediastinal radiotherapy for Hodgkin’s disease. Int J Radiat Oncol Biol Phys. 2011;79(4):1117-23.
29. Traber J, Krempien R, Schulz-Menger J, von Knobelsdorf-Brenkenhof F. Assessment of acute radiation therapy-related cardiotoxicity by cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2016;18(S1):1-2.
30. Lyon AR, López-Fernández T, Couch LS, et al. 2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS). Eur Heart J. 2022;43(41):4229-361.
31. Sárközy M, Varga Z, Gáspár R. Pathomechanisms and therapeutic opportunities in radiation‑induced heart disease: from bench to bedside. Clinical Research in Cardiology. Clin Res Cardiol. 2021;110(4):507-31.
32. DePasquale EC, Nasir K, Jacoby DL. Outcomes of adults with restrictive cardiomyopathy after heart transplantation. J Heart Lung Transplant. 2012;31(12):1269-75.
33. Hansson G. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352(16):1685-95.
34. Desai MY, Windecker S, Lancellotti P, et al. Prevention, Diagnosis, and Management of Radiation-Associated Cardiac Disease JACC Scientific Expert Panel. J Am Coll Cardiol. 2019;74:905-27.
35. Stewart FA, Seemann I, Hoving S, Russell NS. Understanding radiation‑induced cardiovascular damage and strategies for intervention. Clin Oncol (R Coll Radiol). 2013;25:617‑24.
36. Oeffinger KC, Mertens AC, Sklar CA, et al. Childhood Cancer Survivor Study. Chronic health conditions in adult survivors of childhood cancer. N Engl J Med. 2006;355:1572-82.
37. Fajardo LF. The pathology of ionizing radiation as defined by morphologic patterns. Acta Oncol. 2005;44:13-22.
38. Thakker R, Suthar K, Bhakta P, et al. Percutaneous Coronary Intervention Outcomes in Patients With Prior Thoracic Radiation Therapy: A Systematic Review and Meta-Analysis. Cardiol Res. 2022;13(6):333-8.
39. Bijl JM, Roos MM, van Leeuwen-Segarceanu EM, et al. Assessment of valvular disorders in survivors of Hodgkin’s lymphoma treated by mediastinal radiotherapy +/- chemotherapy. Am J Cardiol. 2016;117(4):691-6.
40. Wethal T, Lund MB, Edvardsen T, et al. Valvular dysfunction and left ventricular changes in Hodgkin’s lymphoma survivors. A longitudinal study. Br J Cancer. 2009;101:575-81.
41. Donnellan E, Griffin BP, Johnston DR, et al. Rate of progression of aortic stenosis and its impact on outcomes in patients with radiation-associated cardiac disease: a matched cohort study. J Am Coll Cardiol Img. 2018;11:1072-80.
42. Donnellan E, Masri A, Johnston DR, et al. Long-term outcomes of patients with mediastinal radiation-associated severe aortic stenosis and subsequent surgical aortic valve replacement: a matched cohort study. J Am Heart Assoc. 2017;6(5):e005396.
43. Zafar MR, Mustafa SF, Miller TW, et al. Outcomes after transcatheter aortic valve replacement in cancer survivors with prior chest radiation therapy: a systematic review and meta-analysis. Cardiooncology. 2020;14(6):8.
44. De Bruin ML, Dorresteijn LD, van’t Veer MB, et al. Increased risk of stroke and transient ischemic attack in 5-year survivors of Hodgkin lymphoma. J Natl Cancer Inst. 2009;101:928-37.
45. van Dijk IW, van der Pal HJ, van Os RM, et al. Risk of Symptomatic Stroke After Radiation Therapy for Childhood Cancer: A Long-Term Follow-Up Cohort Analysis. Int J Radiat Oncol Biol Phys. 2016;96(3):597-605.
46. Jurado JA, Bashir R, Burket MW. Radiation-induced peripheral artery disease. Catheter Cardiovasc Interv. 2008;72:563-8.
47. Murphy ES, Xie H, Merchant TE, et al. Review of cranial radiotherapy-induced vasculopathy. J Neurooncol. 2015;122(3):421-9.
48. Ness KK, Armstrong GT. Screening for cardiac autonomic dysfunction among Hodgkin lymphoma survivors treated with thoracic radiation. J Am Coll Cardiol. 2015;65:584-5.
49. Andratschke N, Maurer J, Molls M, Trott KR. Late radiation-induced heart disease after radiotherapy. Clinical importance, radiobiological mechanisms and strategies of prevention. Radiother Oncol. 2011;100:160-6.
50. Szabó G, Schmack B, Bulut C, et al. Constrictive pericarditis: risks, aetiologies and outcomes after total pericardiectomy: 24 years of experience. Eur J Cardiothorac Surg. 2013;44:1023-8.
51. Lai YH, Chen HHW, Tsai YS. Accelerated coronary calcium burden in breast cancer patients after radiotherapy: a comparison with age and race matched healthy women. Radiat Oncol. 2021;16:210.
52. Koppelmans V, Vernooij MW, BoogerdW, et al. Prevalence of cerebral small-vessel disease in long-term breast cancer survivors exposed to both adjuvant radiotherapy and chemotherapy. J Clin Oncol. 2015;33:588-93.
53. Leerink JM, van der Pal HJH, Kremer LCM, et al. Refining the 10-year prediction of left ventricular systolic dysfunction in longterm survivors of childhood cancer. JACC CardioOncology. 2021;3:62-72.
54. Gatta G, Botta L, Rossi S, et al. Childhood cancer survival in Europe 1999–2007: results of EUROCARE-5 – a populationbased study. Lancet Oncol. 2014;15:35-47.
55. Armenian SH, Armstrong GT, Aune G, et al. Cardiovascular disease in survivors of childhood cancer: insights into epidemiology, pathophysiology, and prevention. J Clin Oncol. 2018;36:2135-44.
56. Kremer LCM, van Dalen EC, Offringa M, Voûte PA. Frequency and risk factors of anthracycline-induced clinical heart failure in children: a systematic review. Ann Oncol. 2002;13:503-5.
57. Armstrong GT, Oeffinger KC, Chen Y, et al. Modifiable risk factors and major cardiac events among adult survivors of childhood cancer. J Clin Oncol. 2013;31:3673-80.
58. van Dalen EC, Mulder RL, Suh E, et al. Coronary artery disease surveillance among childhood, adolescent and young adult cancer survivors: a systematic review and recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group. Eur J Cancer. 2021;156:127-37.
59. Armenian SH, Hudson MM, Mulder RL, et al. Recommendations for cardiomyopathy surveillance for survivors of childhood cancer:a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group. Lancet Oncol. 2015;16:e123-36.
Авторы
М.Г. Полтавская*, А.И. Новикова, А.Л. Безлюдский
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия
*poltavskaya_m_g@staff.sechenov.ru
Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
*poltavskaya_m_g@staff.sechenov.ru
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия
*poltavskaya_m_g@staff.sechenov.ru
________________________________________________
Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
*poltavskaya_m_g@staff.sechenov.ru
Цель портала OmniDoctor – предоставление профессиональной информации врачам, провизорам и фармацевтам.
