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Взаимосвязь состава микробиоты кишечника и респираторной инфекции COVID-19
Взаимосвязь состава микробиоты кишечника и респираторной инфекции COVID-19
Капустина Е.А., Соколов Д.В., Жаренков Д.А., Шушунина У.А., Раевский К.П. Взаимосвязь состава микробиоты кишечника и респираторной инфекции COVID-19. Consilium Medicum. 2025;27(8):477–482. DOI: 10.26442/20751753.2025.8.203344
© ООО «КОНСИЛИУМ МЕДИКУМ», 2025 г.
© ООО «КОНСИЛИУМ МЕДИКУМ», 2025 г.
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Аннотация
В статье представлен обзор современной зарубежной и отечественной литературы, обобщающий известные данные о влиянии микробиоты кишечника (МК) на течение COVID-19, а также качественном и количественном изменении состава МК под воздействием новой коронавирусной инфекции. Результаты многих исследований говорят о модулировании микроорганизмами кишечника иммунного ответа при новой коронавирусной инфекции, в том числе посредством стимуляции синтеза цитокинов, иммуноглобулинов, регуляции экспрессии рецепторов-мишеней вируса и поддержания тонуса иммунной системы. С одной стороны, такая закономерность находит отражение в различии тяжести течения заболевания в зависимости от состояния МК. С другой стороны, помимо респираторной симптоматики при инфекции SARS-CoV-2 присутствуют расстройства желудочно-кишечного тракта, что свидетельствует о тропности вируса к клеткам кишечника и влиянии на МК. Описанная двусторонняя связь получила название «ось ”кишечник – легкие”» и открывает перспективы для стимуляции иммунного ответа против SARS-CoV-2 и улучшения прогноза.
Ключевые слова: микробиота, кишечник, COVID-19, коронавирусная инфекция, иммунитет, желудочно-кишечный тракт, гастроэнтерологические проявления коронавирусной инфекции, пробиотики
Keywords: microbiota, intestine, COVID-19, coronavirus infection, immunity, gastrointestinal tract, gastrointestinal signs of coronavirus infection, probiotics
Ключевые слова: микробиота, кишечник, COVID-19, коронавирусная инфекция, иммунитет, желудочно-кишечный тракт, гастроэнтерологические проявления коронавирусной инфекции, пробиотики
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Keywords: microbiota, intestine, COVID-19, coronavirus infection, immunity, gastrointestinal tract, gastrointestinal signs of coronavirus infection, probiotics
Полный текст
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7. Yongjian W, Cheng G, Lantian T, et al. Prolonged presence of SARS-CoV-2 viral RNA in faecal samples. Lancet Gastroenterol Hepatol. 2020;5(5):434-5. DOI:10.1016/S2468-1253(20)30083-2
8. Chen Y, Chen L, Deng Q, et al. The presence of SARS-CoV-2 RNA in the feces of COVID-19 patients. J Med Virol. 2020;92(7):833-40. DOI:10.1002/jmv.25825
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10. Chhibber-Goel J, Gopinathan S, Sharma A. Interplay between severities of COVID-19 and the gut microbiome: implications of bacterial co-infections? Gut Pathog. 2021;13(1):14. DOI:10.1186/s13099-021-00407-7
11. Nagano Y, Itoh K, Honda K. The induction of Treg cells by gut-indigenous Clostridium. Curr Opin Immunol. 2012;24(4):392-7. DOI:10.1016/j.coi.2012.05.007
12. Dumas A, Bernard L, Poquet Y, et al. The role of the lung microbiota and the gut-lung axis in respiratory infectious diseases. Cell Microbiol. 2018;20(12):e12966. DOI:10.1111/cmi.12966
13. Ichinohe T, Pang IK, Kumamoto Y, et al. Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proc Natl Acad Sci U S A. 2011;108(13):5354-9. DOI:10.1073/pnas.1019378108
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48. Kim HN, Joo EJ, Lee CW, et al. Reversion of Gut Microbiota during the Recovery Phase in Patients with Asymptomatic or Mild COVID-19: Longitudinal Study. Microorganisms. 2021;9:1237. DOI:10.3390/microorganisms9061237
49. Zhou Y, Zhang J, Zhang D, et al. Linking the gut microbiota to persistent symptoms in survivors of COVID-19 after discharge. J Microbiol. 2021;59(10):941-8. DOI:10.1007/s12275-021-1206-5
50. Zhang D, Zhou Y, Ma Y, et al. Gut Microbiota Dysbiosis Correlates With Long COVID-19 at One-Year After Discharge. J Korean Med Sci. 2023;38(15):e120. DOI:10.3346/jkms.2023.38.e120
51. Hill C, Guarner F, Reid G, et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11(8):506-14. DOI:10.1038/nrgastro.2014.66
52. Wischmeyer PE, Tang H, Ren Y, et al. Efficacy of probiotic treatment as post-exposure prophylaxis for COVID-19: A double-blind, Placebo-Controlled Randomized trial. Clin Nutr. 2024;43(1):259-67. DOI:10.1016/j.clnu.2023.11.043
53. Leal-Martínez F, Abarca-Bernal L, García-Pérez A, et al. Effect of a Nutritional Support System to Increase Survival and Reduce Mortality in Patients with COVID-19 in Stage III and Comorbidities: A Blinded Randomized Controlled Clinical Trial. Int J Environ Res Public Health. 2022;19(3):1172. DOI:10.3390/ijerph19031172
54. Ivashkin V, Fomin V, Moiseev S, et al. Efficacy of a Probiotic Consisting of Lacticaseibacillus rhamnosus PDV 1705, Bifidobacterium bifidum PDV 0903, Bifidobacterium longum subsp. infantis PDV 1911, and Bifidobacterium longum subsp. longum PDV 2301 in the Treatment of Hospitalized Patients with COVID-19: a Randomized Controlled Trial. Probiotics Antimicrob Proteins. 2023;15:460-8. DOI:10.1007/s12602-021-09858-5
55. Gooruee R, Pahlavani N, Hadi V, Hadi S. Evaluation of the effect of kefir supplementation on inflammatory markers and clinical and hematological indices in COVID-19 patients; a randomized double-blined clinical trial. Advances in Integrative Medicine. 2024;11(1):10-6. DOI:10.1186/s13063-019-4008-x
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49. Zhou Y, Zhang J, Zhang D, et al. Linking the gut microbiota to persistent symptoms in survivors of COVID-19 after discharge. J Microbiol. 2021;59(10):941-8. DOI:10.1007/s12275-021-1206-5
50. Zhang D, Zhou Y, Ma Y, et al. Gut Microbiota Dysbiosis Correlates With Long COVID-19 at One-Year After Discharge. J Korean Med Sci. 2023;38(15):e120. DOI:10.3346/jkms.2023.38.e120
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52. Wischmeyer PE, Tang H, Ren Y, et al. Efficacy of probiotic treatment as post-exposure prophylaxis for COVID-19: A double-blind, Placebo-Controlled Randomized trial. Clin Nutr. 2024;43(1):259-67. DOI:10.1016/j.clnu.2023.11.043
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54. Ivashkin V, Fomin V, Moiseev S, et al. Efficacy of a Probiotic Consisting of Lacticaseibacillus rhamnosus PDV 1705, Bifidobacterium bifidum PDV 0903, Bifidobacterium longum subsp. infantis PDV 1911, and Bifidobacterium longum subsp. longum PDV 2301 in the Treatment of Hospitalized Patients with COVID-19: a Randomized Controlled Trial. Probiotics Antimicrob Proteins. 2023;15:460-8. DOI:10.1007/s12602-021-09858-5
55. Gooruee R, Pahlavani N, Hadi V, Hadi S. Evaluation of the effect of kefir supplementation on inflammatory markers and clinical and hematological indices in COVID-19 patients; a randomized double-blined clinical trial. Advances in Integrative Medicine. 2024;11(1):10-6. DOI:10.1186/s13063-019-4008-x
Авторы
Е.А. Капустина1, Д.В. Соколов*1, Д.А. Жаренков1, У.А. Шушунина1, К.П. Раевский2
1ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России, Санкт-Петербург, Россия;
2ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова», Москва, Россия
*danila-sokolov-danila@mail.ru
1Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia;
2Lomonosov Moscow State University, Moscow, Russia
*danila-sokolov-danila@mail.ru
1ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России, Санкт-Петербург, Россия;
2ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова», Москва, Россия
*danila-sokolov-danila@mail.ru
________________________________________________
1Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia;
2Lomonosov Moscow State University, Moscow, Russia
*danila-sokolov-danila@mail.ru
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