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Современный подход к этиологии, патогенезу, лечению и профилактике бактериального вагиноза и вагинального кандидоза
Современный подход к этиологии, патогенезу, лечению и профилактике бактериального вагиноза и вагинального кандидоза
Пустотина О.А. Современный подход к этиологии, патогенезу, лечению и профилактике бактериального вагиноза
и вагинального кандидоза. Гинекология. 2015; 17 (3): 79–82.
и вагинального кандидоза. Гинекология. 2015; 17 (3): 79–82.
________________________________________________
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Аннотация
В статье с современных позиций рассматриваются этиология, патогенез, диагностика, лечение и профилактика бактериального вагиноза и вагинального кандидоза – самых частых причин вагинальных выделений. Оцениваются место комбинированных препаратов
и значение комплексного подхода в лечении и профилактике нарушений вагинального микробиоценоза.
Ключевые слова: бактериальный вагиноз, вагинальный кандидоз.
Key words: bacterial vaginosis, vaginal candidiasis.
и значение комплексного подхода в лечении и профилактике нарушений вагинального микробиоценоза.
Ключевые слова: бактериальный вагиноз, вагинальный кандидоз.
________________________________________________
Key words: bacterial vaginosis, vaginal candidiasis.
Полный текст
Список литературы
1. Filler SG. Insights from human studies into the host defense against candidiasis. Cytokine 2012; 58 (1): 129–32.
2. Шейка матки, влагалище, вульва. Физиология, патология, кольпоскопия, эстетическая коррекция. Руководство для практикующих врачей. Под ред. С.И.Роговской, Е.В.Липовой. М.: StatusPraesens, 2014. / Sheika matki, vlagalishche, vul'va. Fiziologiia, patologiia, kol'poskopiia, esteticheskaia korrektsiia: rukovodstvo dlia praktikuiushchikh vrachei. Pod red. S.I.Rogovskoi, E.V.Lipovoi. M.: StatusPraesens, 2014. [in Russian]
3. Sweet RL, Gibbs RS. Infectious diseases of the female genital tract. 5th ed. Lippincott Williams Wilkins, 2009.
4. Гуртовой Б.Л., Кулаков В.И., Воропаева С.Д. Применение антибиотиков в акушерстве и гинекологии. М.: Триада-Х, 2004. / Gurtovoi B.L., Kulakov V.I., Voropaeva S.D. Primenenie antibiotikov v akusherstve i ginekologii. M.: Triada-Kh, 2004. [in Russian]
5. Dols JA, Smit PW, Kort R et al. Microarray-based identification of clinically relevant vaginal bacteria in relation to bacterial vaginosis. Am J Obstet Gynecol 2011; 204: 305.e1–7.
6. Hickley RJ, Zhou X, Pierson JD et al. Understanding vaginal microbiome completely from an ecological perspective. Transl Res 2012; 160: 267–82.
7. Ravel J, Gajer P, Abdo Z et al. Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci USA 2011; 108: 4680–7.
8. Swidsinski A, Dorffel Y, Loening-Baucke V et al. Gardnerella biofilm involves females and males and is sexually transmitted. Gynecol Obstet Invest 2010; 70: 256–63.
9. Donders GG, Zodzika J, Rezeberga D. Treatment of bacterial vaginosis: what we have and what we miss. Exp Opin Pharmacother 2014; 15 (5): 645–57.
10. Desseauve D, Chantrel J, Fruchart A et al. Prevalence and risk factors of bacterial vaginosis during the first trimester of pregnancy in a large French population-based study. Eur J Obstet Gynecol Reprod Biol 2012; 163: 30–4.
11. Bothuyne-Queste E et al. Is the bacterial vaginosis risk factor of prematurity? Study of a cohort of 1336 patients in the hospital of Arras. J Gynecol Obstet Biol Reprod 2012; 41 (3): 262–70.
12. Mittal V, Jain A, Pradeep Y. Development of modified diagnostic criteria for bacterial vaginosis at peripheral health centres in developing countries. J Infect Dev Ctries 2012; 6 (5): 373–7.
13. CDC. Sexually Transmitted Diseases Treatment Guidelines 2010. http://www.cdc.gov/std/treatment/2010/pid.htm
14. Sherrard J, Donders G, White D. European (IUSTI/WHO) Guideline on the management of vaginal discharge in women reproductive age. 2011.
15. Клинические рекомендации РОАГ. Акушерство и гинекология. 4-е изд. Под ред. В.Н.Серова, Г.Т.Сухих. М.: ГЭОТАР-Медиа, 2014. / Klinicheskie rekomendatsii ROAG. Akusherstvo i ginekologiia. 4-e izd. Pod red. V.N.Serova, G.T.Sukhikh. M.: GEOTAR-Media, 2014. [in Russian]
16. Подзолкова Н.М., Никитина Т.И. Сравнительная оценка различных схем лечения больных с бактериальным вагинозом и неспецифическим вульвовагинитом. Рос. вестн. акушера-гинеколога. 2012; 4: 75–81. / Podzolkova N.M., Nikitina T.I. Sravnitel'naia otsenka razlichnykh skhem lecheniia bol'nykh s bakterial'nym vaginozom i nespetsificheskim vul'vovaginitom. Ros. vestn. akushera-ginekologa. 2012; 4: 75–81. [in Russian]
17. Verstraelen H, Verhelst R. Bacterial vaginosis: an update on diagnosis and treatment. Expert Rev Anti Infect Ther 2009; 7: 1109–24.
18. Swidsinski A, Verstraelen H, Loening-Baucke V et al. Presence of a polymicrobial endometrial biofilm in patients with bacterial vaginosis. PLoS One 2013; 8: e53997.
19. Подзолкова Н.М., Никитина Т.И. Новые возможности терапии рецидивирующих вульвовагинальных инфекций: анализ и обсуждение результатов многоцентрового исследования БИОС-2. Акушерство и гинекология. 2014; 4: 68–74. / Podzolkova N.M., Nikitina T.I. Novye vozmozhnosti terapii retsidiviruiushchikh vul'vovaginal'nykh infektsii: analiz i obsuzhdenie rezul'tatov mnogotsentrovogo issledovaniia BIOS-2. Akusherstvo i ginekologiia. 2014; 4: 68–74. [in Russian]
20. Ya W, Reifer C, Miller LE. Efficacy of vaginal probiotic capsules for recurrent bacterial vaginosis: a double blind, randomized, placebo-controlled study. Am J Obstet Gynecol 2010; 203: 1200–8.
21. Zodzika J, Rezerberga D, Donders G et al. Impact of vaginal ascorbic acid on abnormal vaginal microflora. Arch Gynecol Obstet 2013; 288: 1039–44.
22. Гомберг М.А., Плахова К. Терапия трихомониаза и бактериального вагиноза: проблемы и пути решения. Consilium Medicum. 2005; 7 (3): 210–4. / Gomberg M.A., Plakhova K. Terapiia trikhomoniaza i bakterial'nogo vaginoza: problemy i puti resheniia. Consilium Medicum. 2005; 7 (3): 210–4. [in Russian]
23. Ozyurt E. Efficacy of 7-day treatment with metronidazole plus miconazole (Neo-Penotran®) – a triple-active pessary for the treatment of single and mixed vaginal infections. Inter J Gynecol Obstet 2001; 74 (1): 35–43.
24. Peixoto F, Camargos A, Duarte G et al. Efficacy and tolerance of metronidazole and miconazole nitrate in treatment of vaginitis. Intern J Gynecol Obstet 2008; 102: 287–92.
25. Schwebke JR, Lensing SY, Sobel J.I ntravaginal Metronidazole/Miconazole for the treatment of Vaginal Trihomoniasis. Sex Transmit Dis 2013; 40 (9): 679–760.
26. Инструкция к препарату Гайномакс. http://www.vidal.ru/drugs/gynomax__30899 / Instuktsiia k preparatu Gainomaks. http://www.vidal.ru/drugs/gynomax__30899 [in Russian]
27. Cagayan S, Bravo SL, Fallarme A. Randomized, singleblind, one centre trial comparing the efficacy, safety and acceptability of 3 day versus 7 day treatment of Gynomax in vaginitis treatment. Controversies in obstetrics, gynecology and infertility. China 2009, Nov 12–15.
28. Фофанова И.Ю., Прилепская В.Н. Рациональные подходы к терапии бактериального вагиноза. Гинекология. 2013; 15 (5)/ Fofanova I.Iu., Prilepskaia V.N. Ratsional'nye podkhody k terapii bakterial'nogo vaginoza. Gynekology. 2013; 15 (5). [in Russian]
29. Pustotina OA. Urogenital infection in pregnant women: clinical signs and outcome. J Perinat Med 2013; 41: 135.
30. Brocklehurst P, Gordon A, Heatly E et al. Antibiotics for treating bacterial vaginosis in pregnancy. Cochr Database Syst Rev 2013; 1: CD000262.
31. Weissenbacher ER, Donders G, Unzeitig V et al. Fluomizin Study Group. A comparison of dequalinium chloride vaginal tablets (Fluomizin®) and clindamycin vaginal cream in the treatment of bacterial vaginosis: a single-blind, randomized clinical trial of efficacy and safety. Gynecol Obstet Invest 2012; 73: 8–15.
2. Sheika matki, vlagalishche, vul'va. Fiziologiia, patologiia, kol'poskopiia, esteticheskaia korrektsiia: rukovodstvo dlia praktikuiushchikh vrachei. Pod red. S.I.Rogovskoi, E.V.Lipovoi. M.: StatusPraesens, 2014. [in Russian]
3. Sweet RL, Gibbs RS. Infectious diseases of the female genital tract. 5th ed. Lippincott Williams Wilkins, 2009.
4. Gurtovoi B.L., Kulakov V.I., Voropaeva S.D. Primenenie antibiotikov v akusherstve i ginekologii. M.: Triada-Kh, 2004. [in Russian]
5. Dols JA, Smit PW, Kort R et al. Microarray-based identification of clinically relevant vaginal bacteria in relation to bacterial vaginosis. Am J Obstet Gynecol 2011; 204: 305.e1–7.
6. Hickley RJ, Zhou X, Pierson JD et al. Understanding vaginal microbiome completely from an ecological perspective. Transl Res 2012; 160: 267–82.
7. Ravel J, Gajer P, Abdo Z et al. Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci USA 2011; 108: 4680–7.
8. Swidsinski A, Dorffel Y, Loening-Baucke V et al. Gardnerella biofilm involves females and males and is sexually transmitted. Gynecol Obstet Invest 2010; 70: 256–63.
9. Donders GG, Zodzika J, Rezeberga D. Treatment of bacterial vaginosis: what we have and what we miss. Exp Opin Pharmacother 2014; 15 (5): 645–57.
10. Desseauve D, Chantrel J, Fruchart A et al. Prevalence and risk factors of bacterial vaginosis during the first trimester of pregnancy in a large French population-based study. Eur J Obstet Gynecol Reprod Biol 2012; 163: 30–4.
11. Bothuyne-Queste E et al. Is the bacterial vaginosis risk factor of prematurity? Study of a cohort of 1336 patients in the hospital of Arras. J Gynecol Obstet Biol Reprod 2012; 41 (3): 262–70.
12. Mittal V, Jain A, Pradeep Y. Development of modified diagnostic criteria for bacterial vaginosis at peripheral health centres in developing countries. J Infect Dev Ctries 2012; 6 (5): 373–7.
13. CDC. Sexually Transmitted Diseases Treatment Guidelines 2010. http://www.cdc.gov/std/treatment/2010/pid.htm
14. Sherrard J, Donders G, White D. European (IUSTI/WHO) Guideline on the management of vaginal discharge in women reproductive age. 2011.
15. Klinicheskie rekomendatsii ROAG. Akusherstvo i ginekologiia. 4-e izd. Pod red. V.N.Serova, G.T.Sukhikh. M.: GEOTAR-Media, 2014. [in Russian]
16. Podzolkova N.M., Nikitina T.I. Sravnitel'naia otsenka razlichnykh skhem lecheniia bol'nykh s bakterial'nym vaginozom i nespetsificheskim vul'vovaginitom. Ros. vestn. akushera-ginekologa. 2012; 4: 75–81. [in Russian]
17. Verstraelen H, Verhelst R. Bacterial vaginosis: an update on diagnosis and treatment. Expert Rev Anti Infect Ther 2009; 7: 1109–24.
18. Swidsinski A, Verstraelen H, Loening-Baucke V et al. Presence of a polymicrobial endometrial biofilm in patients with bacterial vaginosis. PLoS One 2013; 8: e53997.
19. Podzolkova N.M., Nikitina T.I. Novye vozmozhnosti terapii retsidiviruiushchikh vul'vovaginal'nykh infektsii: analiz i obsuzhdenie rezul'tatov mnogotsentrovogo issledovaniia BIOS-2. Akusherstvo i ginekologiia. 2014; 4: 68–74. [in Russian]
20. Ya W, Reifer C, Miller LE. Efficacy of vaginal probiotic capsules for recurrent bacterial vaginosis: a double blind, randomized, placebo-controlled study. Am J Obstet Gynecol 2010; 203: 1200–8.
21. Zodzika J, Rezerberga D, Donders G et al. Impact of vaginal ascorbic acid on abnormal vaginal microflora. Arch Gynecol Obstet 2013; 288: 1039–44.
22. Gomberg M.A., Plakhova K. Terapiia trikhomoniaza i bakterial'nogo vaginoza: problemy i puti resheniia. Consilium Medicum. 2005; 7 (3): 210–4. [in Russian]
23. Ozyurt E. Efficacy of 7-day treatment with metronidazole plus miconazole (Neo-Penotran®) – a triple-active pessary for the treatment of single and mixed vaginal infections. Inter J Gynecol Obstet 2001; 74 (1): 35–43.
24. Peixoto F, Camargos A, Duarte G et al. Efficacy and tolerance of metronidazole and miconazole nitrate in treatment of vaginitis. Intern J Gynecol Obstet 2008; 102: 287–92.
25. Schwebke JR, Lensing SY, Sobel J.I ntravaginal Metronidazole/Miconazole for the treatment of Vaginal Trihomoniasis. Sex Transmit Dis 2013; 40 (9): 679–760.
26. Инструкция к препарату Гайномакс. http://www.vidal.ru/drugs/gynomax__30899 / Instuktsiia k preparatu Gainomaks. http://www.vidal.ru/drugs/gynomax__30899 [in Russian]
27. Cagayan S, Bravo SL, Fallarme A. Randomized, singleblind, one centre trial comparing the efficacy, safety and acceptability of 3 day versus
7 day treatment of Gynomax in vaginitis treatment. Controversies in obstetrics, gynecology and infertility. China 2009, Nov 12–15.
28. Fofanova I.Iu., Prilepskaia V.N. Ratsional'nye podkhody k terapii bakterial'nogo vaginoza. Gynekology. 2013; 15 (5). [in Russian]
29. Pustotina OA. Urogenital infection in pregnant women: clinical signs and outcome. J Perinat Med 2013; 41: 135.
30. Brocklehurst P, Gordon A, Heatly E et al. Antibiotics for treating bacterial vaginosis in pregnancy. Cochr Database Syst Rev 2013; 1: CD000262.
31. Weissenbacher ER, Donders G, Unzeitig V et al. Fluomizin Study Group. A comparison of dequalinium chloride vaginal tablets (Fluomizin®) and clindamycin vaginal cream in the treatment of bacterial vaginosis: a single-blind, randomized clinical trial of efficacy and safety. Gynecol Obstet Invest 2012; 73: 8–15.
2. Шейка матки, влагалище, вульва. Физиология, патология, кольпоскопия, эстетическая коррекция. Руководство для практикующих врачей. Под ред. С.И.Роговской, Е.В.Липовой. М.: StatusPraesens, 2014. / Sheika matki, vlagalishche, vul'va. Fiziologiia, patologiia, kol'poskopiia, esteticheskaia korrektsiia: rukovodstvo dlia praktikuiushchikh vrachei. Pod red. S.I.Rogovskoi, E.V.Lipovoi. M.: StatusPraesens, 2014. [in Russian]
3. Sweet RL, Gibbs RS. Infectious diseases of the female genital tract. 5th ed. Lippincott Williams Wilkins, 2009.
4. Гуртовой Б.Л., Кулаков В.И., Воропаева С.Д. Применение антибиотиков в акушерстве и гинекологии. М.: Триада-Х, 2004. / Gurtovoi B.L., Kulakov V.I., Voropaeva S.D. Primenenie antibiotikov v akusherstve i ginekologii. M.: Triada-Kh, 2004. [in Russian]
5. Dols JA, Smit PW, Kort R et al. Microarray-based identification of clinically relevant vaginal bacteria in relation to bacterial vaginosis. Am J Obstet Gynecol 2011; 204: 305.e1–7.
6. Hickley RJ, Zhou X, Pierson JD et al. Understanding vaginal microbiome completely from an ecological perspective. Transl Res 2012; 160: 267–82.
7. Ravel J, Gajer P, Abdo Z et al. Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci USA 2011; 108: 4680–7.
8. Swidsinski A, Dorffel Y, Loening-Baucke V et al. Gardnerella biofilm involves females and males and is sexually transmitted. Gynecol Obstet Invest 2010; 70: 256–63.
9. Donders GG, Zodzika J, Rezeberga D. Treatment of bacterial vaginosis: what we have and what we miss. Exp Opin Pharmacother 2014; 15 (5): 645–57.
10. Desseauve D, Chantrel J, Fruchart A et al. Prevalence and risk factors of bacterial vaginosis during the first trimester of pregnancy in a large French population-based study. Eur J Obstet Gynecol Reprod Biol 2012; 163: 30–4.
11. Bothuyne-Queste E et al. Is the bacterial vaginosis risk factor of prematurity? Study of a cohort of 1336 patients in the hospital of Arras. J Gynecol Obstet Biol Reprod 2012; 41 (3): 262–70.
12. Mittal V, Jain A, Pradeep Y. Development of modified diagnostic criteria for bacterial vaginosis at peripheral health centres in developing countries. J Infect Dev Ctries 2012; 6 (5): 373–7.
13. CDC. Sexually Transmitted Diseases Treatment Guidelines 2010. http://www.cdc.gov/std/treatment/2010/pid.htm
14. Sherrard J, Donders G, White D. European (IUSTI/WHO) Guideline on the management of vaginal discharge in women reproductive age. 2011.
15. Клинические рекомендации РОАГ. Акушерство и гинекология. 4-е изд. Под ред. В.Н.Серова, Г.Т.Сухих. М.: ГЭОТАР-Медиа, 2014. / Klinicheskie rekomendatsii ROAG. Akusherstvo i ginekologiia. 4-e izd. Pod red. V.N.Serova, G.T.Sukhikh. M.: GEOTAR-Media, 2014. [in Russian]
16. Подзолкова Н.М., Никитина Т.И. Сравнительная оценка различных схем лечения больных с бактериальным вагинозом и неспецифическим вульвовагинитом. Рос. вестн. акушера-гинеколога. 2012; 4: 75–81. / Podzolkova N.M., Nikitina T.I. Sravnitel'naia otsenka razlichnykh skhem lecheniia bol'nykh s bakterial'nym vaginozom i nespetsificheskim vul'vovaginitom. Ros. vestn. akushera-ginekologa. 2012; 4: 75–81. [in Russian]
17. Verstraelen H, Verhelst R. Bacterial vaginosis: an update on diagnosis and treatment. Expert Rev Anti Infect Ther 2009; 7: 1109–24.
18. Swidsinski A, Verstraelen H, Loening-Baucke V et al. Presence of a polymicrobial endometrial biofilm in patients with bacterial vaginosis. PLoS One 2013; 8: e53997.
19. Подзолкова Н.М., Никитина Т.И. Новые возможности терапии рецидивирующих вульвовагинальных инфекций: анализ и обсуждение результатов многоцентрового исследования БИОС-2. Акушерство и гинекология. 2014; 4: 68–74. / Podzolkova N.M., Nikitina T.I. Novye vozmozhnosti terapii retsidiviruiushchikh vul'vovaginal'nykh infektsii: analiz i obsuzhdenie rezul'tatov mnogotsentrovogo issledovaniia BIOS-2. Akusherstvo i ginekologiia. 2014; 4: 68–74. [in Russian]
20. Ya W, Reifer C, Miller LE. Efficacy of vaginal probiotic capsules for recurrent bacterial vaginosis: a double blind, randomized, placebo-controlled study. Am J Obstet Gynecol 2010; 203: 1200–8.
21. Zodzika J, Rezerberga D, Donders G et al. Impact of vaginal ascorbic acid on abnormal vaginal microflora. Arch Gynecol Obstet 2013; 288: 1039–44.
22. Гомберг М.А., Плахова К. Терапия трихомониаза и бактериального вагиноза: проблемы и пути решения. Consilium Medicum. 2005; 7 (3): 210–4. / Gomberg M.A., Plakhova K. Terapiia trikhomoniaza i bakterial'nogo vaginoza: problemy i puti resheniia. Consilium Medicum. 2005; 7 (3): 210–4. [in Russian]
23. Ozyurt E. Efficacy of 7-day treatment with metronidazole plus miconazole (Neo-Penotran®) – a triple-active pessary for the treatment of single and mixed vaginal infections. Inter J Gynecol Obstet 2001; 74 (1): 35–43.
24. Peixoto F, Camargos A, Duarte G et al. Efficacy and tolerance of metronidazole and miconazole nitrate in treatment of vaginitis. Intern J Gynecol Obstet 2008; 102: 287–92.
25. Schwebke JR, Lensing SY, Sobel J.I ntravaginal Metronidazole/Miconazole for the treatment of Vaginal Trihomoniasis. Sex Transmit Dis 2013; 40 (9): 679–760.
26. Инструкция к препарату Гайномакс. http://www.vidal.ru/drugs/gynomax__30899 / Instuktsiia k preparatu Gainomaks. http://www.vidal.ru/drugs/gynomax__30899 [in Russian]
27. Cagayan S, Bravo SL, Fallarme A. Randomized, singleblind, one centre trial comparing the efficacy, safety and acceptability of 3 day versus 7 day treatment of Gynomax in vaginitis treatment. Controversies in obstetrics, gynecology and infertility. China 2009, Nov 12–15.
28. Фофанова И.Ю., Прилепская В.Н. Рациональные подходы к терапии бактериального вагиноза. Гинекология. 2013; 15 (5)/ Fofanova I.Iu., Prilepskaia V.N. Ratsional'nye podkhody k terapii bakterial'nogo vaginoza. Gynekology. 2013; 15 (5). [in Russian]
29. Pustotina OA. Urogenital infection in pregnant women: clinical signs and outcome. J Perinat Med 2013; 41: 135.
30. Brocklehurst P, Gordon A, Heatly E et al. Antibiotics for treating bacterial vaginosis in pregnancy. Cochr Database Syst Rev 2013; 1: CD000262.
31. Weissenbacher ER, Donders G, Unzeitig V et al. Fluomizin Study Group. A comparison of dequalinium chloride vaginal tablets (Fluomizin®) and clindamycin vaginal cream in the treatment of bacterial vaginosis: a single-blind, randomized clinical trial of efficacy and safety. Gynecol Obstet Invest 2012; 73: 8–15.
________________________________________________
2. Sheika matki, vlagalishche, vul'va. Fiziologiia, patologiia, kol'poskopiia, esteticheskaia korrektsiia: rukovodstvo dlia praktikuiushchikh vrachei. Pod red. S.I.Rogovskoi, E.V.Lipovoi. M.: StatusPraesens, 2014. [in Russian]
3. Sweet RL, Gibbs RS. Infectious diseases of the female genital tract. 5th ed. Lippincott Williams Wilkins, 2009.
4. Gurtovoi B.L., Kulakov V.I., Voropaeva S.D. Primenenie antibiotikov v akusherstve i ginekologii. M.: Triada-Kh, 2004. [in Russian]
5. Dols JA, Smit PW, Kort R et al. Microarray-based identification of clinically relevant vaginal bacteria in relation to bacterial vaginosis. Am J Obstet Gynecol 2011; 204: 305.e1–7.
6. Hickley RJ, Zhou X, Pierson JD et al. Understanding vaginal microbiome completely from an ecological perspective. Transl Res 2012; 160: 267–82.
7. Ravel J, Gajer P, Abdo Z et al. Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci USA 2011; 108: 4680–7.
8. Swidsinski A, Dorffel Y, Loening-Baucke V et al. Gardnerella biofilm involves females and males and is sexually transmitted. Gynecol Obstet Invest 2010; 70: 256–63.
9. Donders GG, Zodzika J, Rezeberga D. Treatment of bacterial vaginosis: what we have and what we miss. Exp Opin Pharmacother 2014; 15 (5): 645–57.
10. Desseauve D, Chantrel J, Fruchart A et al. Prevalence and risk factors of bacterial vaginosis during the first trimester of pregnancy in a large French population-based study. Eur J Obstet Gynecol Reprod Biol 2012; 163: 30–4.
11. Bothuyne-Queste E et al. Is the bacterial vaginosis risk factor of prematurity? Study of a cohort of 1336 patients in the hospital of Arras. J Gynecol Obstet Biol Reprod 2012; 41 (3): 262–70.
12. Mittal V, Jain A, Pradeep Y. Development of modified diagnostic criteria for bacterial vaginosis at peripheral health centres in developing countries. J Infect Dev Ctries 2012; 6 (5): 373–7.
13. CDC. Sexually Transmitted Diseases Treatment Guidelines 2010. http://www.cdc.gov/std/treatment/2010/pid.htm
14. Sherrard J, Donders G, White D. European (IUSTI/WHO) Guideline on the management of vaginal discharge in women reproductive age. 2011.
15. Klinicheskie rekomendatsii ROAG. Akusherstvo i ginekologiia. 4-e izd. Pod red. V.N.Serova, G.T.Sukhikh. M.: GEOTAR-Media, 2014. [in Russian]
16. Podzolkova N.M., Nikitina T.I. Sravnitel'naia otsenka razlichnykh skhem lecheniia bol'nykh s bakterial'nym vaginozom i nespetsificheskim vul'vovaginitom. Ros. vestn. akushera-ginekologa. 2012; 4: 75–81. [in Russian]
17. Verstraelen H, Verhelst R. Bacterial vaginosis: an update on diagnosis and treatment. Expert Rev Anti Infect Ther 2009; 7: 1109–24.
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Авторы
О.А.Пустотина*
ФГАОУ ВО Российский университет дружбы народов. 117198, Россия, Москва, ул. Миклухо-Маклая, д. 6
*rudn@rudn.ru
People’s Friendship University of Russia. 117198, Russian Federation, Moscow, ul. Miklukho-Maklaya, d. 6
*rudn@rudn.ru
ФГАОУ ВО Российский университет дружбы народов. 117198, Россия, Москва, ул. Миклухо-Маклая, д. 6
*rudn@rudn.ru
________________________________________________
People’s Friendship University of Russia. 117198, Russian Federation, Moscow, ul. Miklukho-Maklaya, d. 6
*rudn@rudn.ru
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