Переносимость и степень удовлетворенности пациенток при использовании различных внутриматочных контрацептивов: результаты наблюдательной программы МИРАБЕЛЬ
Переносимость и степень удовлетворенности пациенток при использовании различных внутриматочных контрацептивов: результаты наблюдательной программы МИРАБЕЛЬ
Андреева Е.Н. Переносимость и степень удовлетворенности пациенток при использовании различных внутриматочных контрацептивов:
результаты наблюдательной программы МИРАБЕЛЬ. Гинекология. 2015; 17 (5): 37–43.
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Andreeva E.N. Tolerability and patient satisfaction using different intrauterine contraceptive: results of the observation program MIRABEL. Gynecology. 2015; 17 (5): 37–43
Переносимость и степень удовлетворенности пациенток при использовании различных внутриматочных контрацептивов: результаты наблюдательной программы МИРАБЕЛЬ
Андреева Е.Н. Переносимость и степень удовлетворенности пациенток при использовании различных внутриматочных контрацептивов:
результаты наблюдательной программы МИРАБЕЛЬ. Гинекология. 2015; 17 (5): 37–43.
________________________________________________
Andreeva E.N. Tolerability and patient satisfaction using different intrauterine contraceptive: results of the observation program MIRABEL. Gynecology. 2015; 17 (5): 37–43
Высокая частота незапланированной беременности остается значительной проблемой во многих странах мира, включая Россию. Этот показатель может быть существенно снижен при применении обратимых контрацептивных методов длительного действия, к которым относятся внутриматочные контрацептивы: выделяющая левоноргестрел внутриматочная терапевтическая гормональная система и медьсодержащие внутриматочные средства. Внутриматочные контрацептивные средства высокоэффективны, характеризуются малым числом противопоказаний и побочных эффектов, экономически рентабельны при длительном применении и могут быть хорошим выбором для большинства женщин. В статье представлены результаты проспективной многоцентровой неинтервенционной сравнительной наблюдательной программы, главной целью которой явилось изучение переносимости внутриматочных контрацептивов и степени удовлетворенности пациентов результатами их применения. Ключевые слова: контрацепция, обратимые контрацептивные методы длительного действия, внутриматочная терапевтическая гормональная система Мирена, медьсодержащие внутриматочные средства.
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The high incidence of unintended pregnancy remains a significant problem in many countries, including Russia. This figure can be significantly reduced when using reversible contraceptive methods for a long-acting, which include intrauterine levonorgestrel – therapeutic hormonal system and copper-containing intrauterine contraceptive means. Intrauterine remedies are highly assessed and effective, being characterized by a small number of contraindications and side effects with long-term economic viability application and can be a good choise for most women. The article presents the results of a multicenter non-interventional prospective comparative observational program, the main aim of which was to examine the tolerability of intrauterine and patient satisfaction results of their application. Key words: contraception, reversible contraceptive methods for a long-acting, intrauterine therapeutic hormonal system Mirena, copper-bearing intrauterine devices.
1. Mosher W, Jones J, Abma J. Nonuse of contraception among women at risk of unintended pregnancy in the United States. Contraception 2015; 92 (2): 170–6.
2. United Nations, Department of Economic and Social Affairs, Population Division. World Contraceptive Use 2009. http://www.un.org/ esa/population/publications/WCU2009/Main.html.Accessed July 20, 2010
3. Smith JD, Oakley D. Why do women miss oral contraceptive pills? An analysis of women's self-described reasons for missed pills. J Midwifery Womens Health 2005; 50: 380–5.
4. Grimes DA. Forgettable contraception. Contraception 2009; 80: 497–9.
5. Peipert JF, Zhao Q, Allsworth JE et al. Continuation and satisfaction of reversible contraception. Obstet Gynecol 2011; 117: 1105–13.
6. Moreau C, Trussell J, Desfreres J, Bajos N. Patterns of contraceptive use before and after an abortion: results from a nationally representative survey of women undergoing anabortion in France. Contraception 2010; 82: 337–44.
7. ACOG Committee on Gynecologic Practice; Long-Acting Reversible Contraception Working Group. ACOG Committee Opinion no. 450: Increasing use of contraceptive implants and intrauterine devices to reduce unintended pregnancy. Obstet Gynecol 2009; 114 (6): 1434–8.
8. Blumenthal PD, Voedisch A, Gemzell-Danielsson K. Strategies to prevent unintended pregnancy: increasing use of long-acting reversible contraception. Hum Reprod Update 2010; 17 (1): 121–37.
9. Berenson AB, Tan A, Jacqueline M et al. Complications and continuation rates associated with 2 types of long-acting contraception. Am J Obstet Gynecol 2015; 212 (6): 761–9.
10. Mosher WD, Jones J. Use of contraception in the United States: 1982–2008. National Center for Health Statistics. Vital Health Stat 2010; 23 (29): 1–44.
11. Eeckhaut MCW, Sweeney MM, Gipson JD. Who Is Using Long-Acting Reversible Contraceptive Methods? Findings from Nine Low-Fertility Countries. Perspect Sex Reprod Health 2014; 46 (3): 149–15.
12. Прилепская В.Н., Тагиева А.В., Межевитинова Е.А. Внутриматочная контрацепция. Под. ред. В.Н.Прилепской. М., 2014; с. 40. / Prilepskaia V.N., Tagieva A.V., Mezhevitinova E.A. Vnutrimatochnaia kontratseptsiia. Pod. red. V.N.Prilepskoi. M., 2014; s. 40. [in Russian]
13. Allen RH, Goldberg AB, Grimes DA. Expanding access to intrauterine contraception. Am J Obstet Gynecol 2009; 201 (5): 456–61.
14. Leeman L. Medical barriers to effective contraception. Obstet Gynecol Clin North Am 2007; 34 (1): 19–29.
15. Dehlendorf C, Tharayil M, Anderson N et al. Counseling About IUDs: A Mixed-Methods Analysis. Perspect Sex Reprod Health 2014; 46 (3): 133–40.
16. Fleming K, Sokoloff A, Raine TR. Attitudes and beliefs about the IUD among teenagers and young women. Contraception 2010; 82: 178–82.
17. Institute of Medicine. Report Brief. Institute of Medicine of the National Academies; Jun. 2009 Initial national priorities for comparative effectiveness research. www.iom.edu/cerpriorities
18. Steinauer JE, Upadhyay UD, Sokoloff A et al. Choice of the levonorgestrel intrauterine device, etonogestrel implant or depot medroxyprogesterone acetate for contraception after aspiration abortion. Contraception 2015. pii: S0010-7824(15)00251-6
19. Winner B, Peipert JF, Zhao Q et al. Effectiveness of Long-Acting Reversible Contraception. N Engl J Med 2012; 366: 1998–2007.
20. ACOG Practice Bulletin No. 121: Long-Acting Reversible Contraception: Implants and Intrauterine Devices. Obstet Gynecol 2011; 118: 184–96.
21. Trussell J, Lalla AM, Doan QV et al. Cost effectiveness of contraceptives in the United States. Contraception 2009; 79: 5–14.
22. Kaneshiro B, Aeby T. Long-term safety, efficacy, and patient accept ability of the intrauterine copper T-380A contraceptive device. Int J Womens Health 2010; 2: 211–20.
23. O’Neil-Callahan M, Peipert JF, Zhao Q et al. Twenty-four-month continuation of reversible contraception. Obstet Gynecol 2013; 122: 1083–91.
24. Grunloh DS, Casner T, Secura GM et al. Characteristics associated with discontinuation of long-acting reversible contraception within the first 6 months of use. Obstet Gynecol 2013; 122: 1214–21.
25. Diedrich JT, Desai S, Zhao Q et al. Association of short-term bleeding and cramping patterns with long-acting reversible contraceptive method satisfaction. Am J Obstet Gynecol 2015; 212: 50.e1–8.
26. Bahamondes MV, Monteiro I, Canteiro R et al. Length of the endometrial cavity and intrauterine contraceptive device expulsion. Int J Gynaecol Obstet 2011; 113 (1): 50–3.
27. Madden T, McNicholas C, Zhao Q et al. Association of age and parity with intrauterine device expulsion. Obstet Gynecol 2014; 124 (4): 718–26.
28. Secura GM, Allsworth JE, Madden T et al. The Contraceptive CHOICE Project: reducing barriers tolong-acting reversible contraception. Am J Obstet Gynecol 2010; 203 (2): 11522–115.
29. Xu H, Wade JA, Peipert JF et al. Contraceptive failure rates of etonogestrel subdermal implants in overweight and obese women. Obstet Gynecol 2012; 120: 21–6.
30. Макаров И.О., Боровкова Е.И. Контрацепция у пациенток с ожирением. Акушерство и гинекология. 2013; 7 (1): 36. / Makarov I.O., Borovkova E.I. Kontratseptsiia u patsientok s ozhireniem. Akusherstvo i ginekologiia. 2013; 7 (1): 36. [in Russian]
31. Gemzell-Danielsson K, Pirjo I, Heikinheimo O. Safety and efficacy of the levonorgestrel-releasing intrauterine system: recent in sights. Exp Rev Obstet Gynecol 2013; 8 (3): 235–47.
32. Vilos GA, Marks J, Tureanu V et al. The levonorgestrel intrauterine system is an effective treatment in selected obese women with abnormal uterine bleeding. J Minim Invasive Gynecol 2011; 18 (1): 75–80.
33. Robinson JA, Burke AE. Obesity and hormonal contraceptive efficacy. Womens Health (Lond Engl) 2013; 9 (5): 453–66.
34. Wildemeersch D. Potential health benefits of continuous LNG-IUS combined with parenteral ERT for seamless menopausal transition and beyond – a commentary based on clinical experience. Gynecol Endocrinol 2013; 29 (6): 569–73.
35. Шестакова И.Г, Хамошина М.Б., Лебедева М.Г., Осьмакова А.А. Терапевтические возможности левоноргестрел-выделяющей внутриматочной системы у женщин в перименопаузе. Фарматека. 2015; 3: 66–70. / Shestakova I.G, Khamoshina M.B., Lebedeva M.G., Os'makova A.A. Terapevticheskie vozmozhnosti levonorgestrel-vydeliaiushchei vnutrimatochnoi sistemy u zhenshchin v perimenopauze. Farmateka. 2015; 3: 66–70. [in Russian]
36. Cleland K, Peipert JF, Westhoff C et al. Family planning as a cost-saving preventive health service. N Engl J Med 2011; 364 (18): e37.
37. Mavranezouli I. The cost-effectiveness of long-acting reversible contraceptive methods in the UK: analysis based on a decision-analytic model developed for a National Institute for Health and Clinical Excellence (NICE) clinical practice guideline. Hum Reprod 2008; 23: 1338–45.
38. Trussell J, Wynn LL. Reducing unintended pregnancy in the United States. Contraception 2008; 77: 1–5.
39. Cleland J. Contraception in historical and global perspective. Best Pract Res Clin Obstet Gynaecol 2009; 23 (2): 165–76.
________________________________________________
1. Mosher W, Jones J, Abma J. Nonuse of contraception among women at risk of unintended pregnancy in the United States. Contraception 2015; 92 (2): 170–6.
2. United Nations, Department of Economic and Social Affairs, Population Division. World Contraceptive Use 2009. http://www.un.org/ esa/population/publications/WCU2009/Main.html.Accessed July 20, 2010
3. Smith JD, Oakley D. Why do women miss oral contraceptive pills? An analysis of women's self-described reasons for missed pills. J Midwifery Womens Health 2005; 50: 380–5.
4. Grimes DA. Forgettable contraception. Contraception 2009; 80: 497–9.
5. Peipert JF, Zhao Q, Allsworth JE et al. Continuation and satisfaction of reversible contraception. Obstet Gynecol 2011; 117: 1105–13.
6. Moreau C, Trussell J, Desfreres J, Bajos N. Patterns of contraceptive use before and after an abortion: results from a nationally representative survey of women undergoing anabortion in France. Contraception 2010; 82: 337–44.
7. ACOG Committee on Gynecologic Practice; Long-Acting Reversible Contraception Working Group. ACOG Committee Opinion no. 450: Increasing use of contraceptive implants and intrauterine devices to reduce unintended pregnancy. Obstet Gynecol 2009; 114 (6): 1434–8.
8. Blumenthal PD, Voedisch A, Gemzell-Danielsson K. Strategies to prevent unintended pregnancy: increasing use of long-acting reversible contraception. Hum Reprod Update 2010; 17 (1): 121–37.
9. Berenson AB, Tan A, Jacqueline M et al. Complications and continuation rates associated with 2 types of long-acting contraception. Am J Obstet Gynecol 2015; 212 (6): 761–9.
10. Mosher WD, Jones J. Use of contraception in the United States: 1982–2008. National Center for Health Statistics. Vital Health Stat 2010; 23 (29): 1–44.
11. Eeckhaut MCW, Sweeney MM, Gipson JD. Who Is Using Long-Acting Reversible Contraceptive Methods? Findings from Nine Low-Fertility Countries. Perspect Sex Reprod Health 2014; 46 (3): 149–15.
12. Prilepskaia V.N., Tagieva A.V., Mezhevitinova E.A. Vnutrimatochnaia kontratseptsiia. Pod. red. V.N.Prilepskoi. M., 2014; s. 40. [in Russian]
13. Allen RH, Goldberg AB, Grimes DA. Expanding access to intrauterine contraception. Am J Obstet Gynecol 2009; 201 (5): 456–61.
14. Leeman L. Medical barriers to effective contraception. Obstet Gynecol Clin North Am 2007; 34 (1): 19–29.
15. Dehlendorf C, Tharayil M, Anderson N et al. Counseling About IUDs: A Mixed-Methods Analysis. Perspect Sex Reprod Health 2014; 46 (3): 133–40.
16. Fleming K, Sokoloff A, Raine TR. Attitudes and beliefs about the IUD among teenagers and young women. Contraception 2010; 82: 178–82.
17. Institute of Medicine. Report Brief. Institute of Medicine of the National Academies; Jun. 2009 Initial national priorities for comparative effectiveness research. www.iom.edu/cerpriorities
18. Steinauer JE, Upadhyay UD, Sokoloff A et al. Choice of the levonorgestrel intrauterine device, etonogestrel implant or depot medroxyprogesterone acetate for contraception after aspiration abortion. Contraception 2015. pii: S0010-7824(15)00251-6
19. Winner B, Peipert JF, Zhao Q et al. Effectiveness of Long-Acting Reversible Contraception. N Engl J Med 2012; 366: 1998–2007.
20. ACOG Practice Bulletin No. 121: Long-Acting Reversible Contraception: Implants and Intrauterine Devices. Obstet Gynecol 2011; 118: 184–96.
21. Trussell J, Lalla AM, Doan QV et al. Cost effectiveness of contraceptives in the United States. Contraception 2009; 79: 5–14.
22. Kaneshiro B, Aeby T. Long-term safety, efficacy, and patient accept ability of the intrauterine copper T-380A contraceptive device. Int J Womens Health 2010; 2: 211–20.
23. O’Neil-Callahan M, Peipert JF, Zhao Q et al. Twenty-four-month continuation of reversible contraception. Obstet Gynecol 2013; 122: 1083–91.
24. Grunloh DS, Casner T, Secura GM et al. Characteristics associated with discontinuation of long-acting reversible contraception within the first 6 months of use. Obstet Gynecol 2013; 122: 1214–21.
25. Diedrich JT, Desai S, Zhao Q et al. Association of short-term bleeding and cramping patterns with long-acting reversible contraceptive method satisfaction. Am J Obstet Gynecol 2015; 212: 50.e1–8.
26. Bahamondes MV, Monteiro I, Canteiro R et al. Length of the endometrial cavity and intrauterine contraceptive device expulsion. Int J Gynaecol Obstet 2011; 113 (1): 50–3.
27. Madden T, McNicholas C, Zhao Q et al. Association of age and parity with intrauterine device expulsion. Obstet Gynecol 2014; 124 (4): 718–26.
28. Secura GM, Allsworth JE, Madden T et al. The Contraceptive CHOICE Project: reducing barriers tolong-acting reversible contraception. Am J Obstet Gynecol 2010; 203 (2): 11522–115.
29. Xu H, Wade JA, Peipert JF et al. Contraceptive failure rates of etonogestrel subdermal implants in overweight and obese women. Obstet Gynecol 2012; 120: 21–6.
30. Makarov I.O., Borovkova E.I. Kontratseptsiia u patsientok s ozhireniem. Akusherstvo i ginekologiia. 2013; 7 (1): 36. [in Russian]
31. Gemzell-Danielsson K, Pirjo I, Heikinheimo O. Safety and efficacy of the levonorgestrel-releasing intrauterine system: recent in sights. Exp Rev Obstet Gynecol 2013; 8 (3): 235–47.
32. Vilos GA, Marks J, Tureanu V et al. The levonorgestrel intrauterine system is an effective treatment in selected obese women with abnormal uterine bleeding. J Minim Invasive Gynecol 2011; 18 (1): 75–80.
33. Robinson JA, Burke AE. Obesity and hormonal contraceptive efficacy. Womens Health (Lond Engl) 2013; 9 (5): 453–66.
34. Wildemeersch D. Potential health benefits of continuous LNG-IUS combined with parenteral ERT for seamless menopausal transition and beyond – a commentary based on clinical experience. Gynecol Endocrinol 2013; 29 (6): 569–73.
35. Shestakova I.G, Khamoshina M.B., Lebedeva M.G., Os'makova A.A. Terapevticheskie vozmozhnosti levonorgestrel-vydeliaiushchei vnutrimatochnoi sistemy u zhenshchin v perimenopauze. Farmateka. 2015; 3: 66–70. [in Russian]
36. Cleland K, Peipert JF, Westhoff C et al. Family planning as a cost-saving preventive health service. N Engl J Med 2011; 364 (18): e37.
37. Mavranezouli I. The cost-effectiveness of long-acting reversible contraceptive methods in the UK: analysis based on a decision-analytic model developed for a National Institute for Health and Clinical Excellence (NICE) clinical practice guideline. Hum Reprod 2008; 23: 1338–45.
38. Trussell J, Wynn LL. Reducing unintended pregnancy in the United States. Contraception 2008; 77: 1–5.
39. Cleland J. Contraception in historical and global perspective. Best Pract Res Clin Obstet Gynaecol 2009; 23 (2): 165–76.
Авторы
Е.Н.Андреева*
ФГБУ Эндокринологический научный центр Минздрава России. 117036, Россия, Москва, ул. Дмитрия Ульянова, д. 11
*gynec@endocrincentr.ru
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E.N.Andreeva*
Endocrinology research center of the Ministry of Health of the Russian Federation. 117036, Russian Federation, Moscow, ul. Dmitria Ul'ianova, d. 11
*gynec@endocrincentr.ru