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Возможности терапии угрозы преждевременных родов
Возможности терапии угрозы преждевременных родов
Доброхотова Ю.Э., Джохадзе Л.С., Копылова Ю.В. Возможности терапии угрозы преждевременных родов. Гинекология. 2016; 18 (1): 68–70.
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Аннотация
В статье рассматривается сравнительная оценка разных методов терапии угрозы преждевременных родов; проанализирована эффективность терапии и исходы у 45 беременных, которым в качестве терапии угрозы преждевременных родов проводился острый внутривенный токолиз с последующим переходом на поддерживающий токолиз в сочетании с интравагинальным применением микронизированного натурального прогестерона. В группу сравнения вошли 42 пациентки, которым проводился только острый токолиз. По мнению авторов, предпочтителен перевод беременных с острого токолиза на поддерживающую токолитическую терапию таблетированными формами с одновременным применением микронизированных форм прогестерона.
Ключевые слова: преждевременные роды, токолиз, эффективность, прогестерон, терапия.
Key words: preterm labor, tocolysis, effectiveness, progesterone, therapy.
Ключевые слова: преждевременные роды, токолиз, эффективность, прогестерон, терапия.
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Key words: preterm labor, tocolysis, effectiveness, progesterone, therapy.
Полный текст
Список литературы
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9. Gerli S, Favilli A, Giordano C et al. Single indications of induction of labor with prostaglandins and risk of cesarean delivery: a retrospective cohort study. J Obstet Gynaecol Res 2013; 39 (5): 926–31.
10. Honest H, Forbes CA, Duree KH et al. Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modeling. Health Technol Assess 2009; 13: l–627.
11. Romero R, Dey SK, Fisher SJ. Preterm labor: one syndrome, many causes. Science 2014; 345 (6198): 760–5. doi: 10.1126/science.1251816. Epub 2014 Aug 14.
12. Romero R, Hassan SS, Gajer P et al. The vaginal microbiota of pregnant women who subsequently have spontaneous preterm labor and delivery and those with a normal delivery at term. J Microbiome 2014; 2: 18.
13. Kim YM, Chaemsaithong P, Romero R et al. The Frequency of Acute Atherosis in Normal Pregnancy and Preterm Labor, Preeclampsia, Small for Gestational Age, Fetal Death and Midtrimester Spontaneous Abortion. J Matern Fetal Neonatal Med 2014; p. 1–24.
14. McCubbin K, Moore S, MacDonald R, Vaillancourt C. Medical Transfer of Patients in Preterm Labor: Treatments and Tocolytics. Prehosp Emerg Care 2014.
15. Мандрыкина Ж.А., Менжинская И.В., Озерова Р.И. и др. Аутосенсибилизация к гормонам при невынашивании беременности. Акушерство и гинекология. 2009; 6: 14–6. / Mandrykina Zh.A., Menzhinskaia I.V., Ozerova R.I. i dr. Autosensibilizatsiia k gormonam pri nevynashivanii beremennosti. Akusherstvo i ginekologiia. 2009; 6: 14–6. [in Russian]
16. Yuce O, Bicer OS, Kavuncuoglu S et al. Prematurity, infection, mortality, morbidity and interleukins: the reason or the result of preterm labor? Minerva Pediatr 2014; 66 (6): 563–70.
2. Crowther CA, Brown J, McKinlay CJ, Middleton P. Magnesium sulphate for preventing preterm birth in threatened preterm labour. Cochrane Database Syst Rev 2014; 8.
3. Radzinskii V.E. Prezhdevremennye rody i perspektivy primeneniia progesterona dlia ikh profilaktiki. Zdorov'e zhenshchiny. 2013; 3 (79): 96. [in Russian]
4. Di Renzo GC, Roura LC, Facchinetti F. Guidelines for the management of spontaneous preterm labor: identification of spontaneous preterm labor, diagnosis of preterm premature rupture of membranes, and preventive tools for preterm birth. J Matern Fetal Neonatal Med. 2011; 24 (5): 659–67.
5. Serov V.N., Sukhorukova O.I. Prezhdevremennye rody – diagnostika i terapiia. Med. sovet. 2014; 9: 50–3. [in Russian]
6. Dobrokhotova Iu.E., Stepanian A.V., Sudakova G.Iu. Mikronizirovannyi progesteron v terapii ugrozy prezhdevremennykh rodov: sistematicheskii obzor i meta-analiz randomizirovannykh i kontroliruemykh issledovanii. Vopr. ginekologii, akusherstva i perinatologii. 2010; 9 (4): 63–70. [in Russian]
7. Doyle LW, Anderson PJ, Haslam R et al. School-age outcomes of very preterm infants after antenatal treatment with magnesium sulfate vs placebo. Australasian Collaborative Trial of Magnesium Sulphate (ACTOMgSO4) Study Group. JAMA 2014; 312 (11): 1105–13.
8. Di Renzo GC, Giardina I, Clerici G et al. The role of progesterone in maternal and fetal medicine. Gynecol Endocrinol 2012; 28 (11): 925–32.
9. Gerli S, Favilli A, Giordano C et al. Single indications of induction of labor with prostaglandins and risk of cesarean delivery: a retrospective cohort study. J Obstet Gynaecol Res 2013; 39 (5): 926–31.
10. Honest H, Forbes CA, Duree KH et al. Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modeling. Health Technol Assess 2009; 13: l–627.
11. Romero R, Dey SK, Fisher SJ. Preterm labor: one syndrome, many causes. Science 2014; 345 (6198): 760–5. doi: 10.1126/science.1251816. Epub 2014 Aug 14.
12. Romero R, Hassan SS, Gajer P et al. The vaginal microbiota of pregnant women who subsequently have spontaneous preterm labor and delivery and those with a normal delivery at term. J Microbiome 2014; 2: 18.
13. Kim YM, Chaemsaithong P, Romero R et al. The Frequency of Acute Atherosis in Normal Pregnancy and Preterm Labor, Preeclampsia, Small for Gestational Age, Fetal Death and Midtrimester Spontaneous Abortion. J Matern Fetal Neonatal Med 2014; p. 1–24.
14. McCubbin K, Moore S, MacDonald R, Vaillancourt C. Medical Transfer of Patients in Preterm Labor: Treatments and Tocolytics. Prehosp Emerg Care 2014.
15. Mandrykina Zh.A., Menzhinskaia I.V., Ozerova R.I. i dr. Autosensibilizatsiia k gormonam pri nevynashivanii beremennosti. Akusherstvo i ginekologiia. 2009; 6: 14–6. [in Russian]
16. Yuce O, Bicer OS, Kavuncuoglu S et al. Prematurity, infection, mortality, morbidity and interleukins: the reason or the result of preterm labor? Minerva Pediatr 2014; 66 (6): 563–70.
2. Crowther CA, Brown J, McKinlay CJ, Middleton P. Magnesium sulphate for preventing preterm birth in threatened preterm labour. Cochrane Database Syst Rev 2014; 8.
3. Радзинский В.Е. Преждевременные роды и перспективы применения прогестерона для их профилактики. Здоровье женщины. 2013; 3 (79): 96. / Radzinskii V.E. Prezhdevremennye rody i perspektivy primeneniia progesterona dlia ikh profilaktiki. Zdorov'e zhenshchiny. 2013; 3 (79): 96. [in Russian]
4. Di Renzo GC, Roura LC, Facchinetti F. Guidelines for the management of spontaneous preterm labor: identification of spontaneous preterm labor, diagnosis of preterm premature rupture of membranes, and preventive tools for preterm birth. J Matern Fetal Neonatal Med. 2011; 24 (5): 659–67.
5. Серов В.Н., Сухорукова О.И. Преждевременные роды – диагностика и терапия. Мед. совет. 2014; 9: 50–3. / Serov V.N., Sukhorukova O.I. Prezhdevremennye rody – diagnostika i terapiia. Med. sovet. 2014; 9: 50–3. [in Russian]
6. Доброхотова Ю.Э., Степанян А.В., Судакова Г.Ю. Микронизированный прогестерон в терапии угрозы преждевременных родов: систематический обзор и мета-анализ рандомизированных и контролируемых исследований. Вопр. гинекологии, акушерства и перинатологии. 2010; 9 (4): 63–70. / Dobrokhotova Iu.E., Stepanian A.V., Sudakova G.Iu. Mikronizirovannyi progesteron v terapii ugrozy prezhdevremennykh rodov: sistematicheskii obzor i meta-analiz randomizirovannykh i kontroliruemykh issledovanii. Vopr. ginekologii, akusherstva i perinatologii. 2010; 9 (4): 63–70. [in Russian]
7. Doyle LW, Anderson PJ, Haslam R et al. School-age outcomes of very preterm infants after antenatal treatment with magnesium sulfate vs placebo. Australasian Collaborative Trial of Magnesium Sulphate (ACTOMgSO4) Study Group. JAMA 2014; 312 (11): 1105–13.
8. Di Renzo GC, Giardina I, Clerici G et al. The role of progesterone in maternal and fetal medicine. Gynecol Endocrinol 2012; 28 (11): 925–32.
9. Gerli S, Favilli A, Giordano C et al. Single indications of induction of labor with prostaglandins and risk of cesarean delivery: a retrospective cohort study. J Obstet Gynaecol Res 2013; 39 (5): 926–31.
10. Honest H, Forbes CA, Duree KH et al. Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modeling. Health Technol Assess 2009; 13: l–627.
11. Romero R, Dey SK, Fisher SJ. Preterm labor: one syndrome, many causes. Science 2014; 345 (6198): 760–5. doi: 10.1126/science.1251816. Epub 2014 Aug 14.
12. Romero R, Hassan SS, Gajer P et al. The vaginal microbiota of pregnant women who subsequently have spontaneous preterm labor and delivery and those with a normal delivery at term. J Microbiome 2014; 2: 18.
13. Kim YM, Chaemsaithong P, Romero R et al. The Frequency of Acute Atherosis in Normal Pregnancy and Preterm Labor, Preeclampsia, Small for Gestational Age, Fetal Death and Midtrimester Spontaneous Abortion. J Matern Fetal Neonatal Med 2014; p. 1–24.
14. McCubbin K, Moore S, MacDonald R, Vaillancourt C. Medical Transfer of Patients in Preterm Labor: Treatments and Tocolytics. Prehosp Emerg Care 2014.
15. Мандрыкина Ж.А., Менжинская И.В., Озерова Р.И. и др. Аутосенсибилизация к гормонам при невынашивании беременности. Акушерство и гинекология. 2009; 6: 14–6. / Mandrykina Zh.A., Menzhinskaia I.V., Ozerova R.I. i dr. Autosensibilizatsiia k gormonam pri nevynashivanii beremennosti. Akusherstvo i ginekologiia. 2009; 6: 14–6. [in Russian]
16. Yuce O, Bicer OS, Kavuncuoglu S et al. Prematurity, infection, mortality, morbidity and interleukins: the reason or the result of preterm labor? Minerva Pediatr 2014; 66 (6): 563–70.
________________________________________________
2. Crowther CA, Brown J, McKinlay CJ, Middleton P. Magnesium sulphate for preventing preterm birth in threatened preterm labour. Cochrane Database Syst Rev 2014; 8.
3. Radzinskii V.E. Prezhdevremennye rody i perspektivy primeneniia progesterona dlia ikh profilaktiki. Zdorov'e zhenshchiny. 2013; 3 (79): 96. [in Russian]
4. Di Renzo GC, Roura LC, Facchinetti F. Guidelines for the management of spontaneous preterm labor: identification of spontaneous preterm labor, diagnosis of preterm premature rupture of membranes, and preventive tools for preterm birth. J Matern Fetal Neonatal Med. 2011; 24 (5): 659–67.
5. Serov V.N., Sukhorukova O.I. Prezhdevremennye rody – diagnostika i terapiia. Med. sovet. 2014; 9: 50–3. [in Russian]
6. Dobrokhotova Iu.E., Stepanian A.V., Sudakova G.Iu. Mikronizirovannyi progesteron v terapii ugrozy prezhdevremennykh rodov: sistematicheskii obzor i meta-analiz randomizirovannykh i kontroliruemykh issledovanii. Vopr. ginekologii, akusherstva i perinatologii. 2010; 9 (4): 63–70. [in Russian]
7. Doyle LW, Anderson PJ, Haslam R et al. School-age outcomes of very preterm infants after antenatal treatment with magnesium sulfate vs placebo. Australasian Collaborative Trial of Magnesium Sulphate (ACTOMgSO4) Study Group. JAMA 2014; 312 (11): 1105–13.
8. Di Renzo GC, Giardina I, Clerici G et al. The role of progesterone in maternal and fetal medicine. Gynecol Endocrinol 2012; 28 (11): 925–32.
9. Gerli S, Favilli A, Giordano C et al. Single indications of induction of labor with prostaglandins and risk of cesarean delivery: a retrospective cohort study. J Obstet Gynaecol Res 2013; 39 (5): 926–31.
10. Honest H, Forbes CA, Duree KH et al. Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modeling. Health Technol Assess 2009; 13: l–627.
11. Romero R, Dey SK, Fisher SJ. Preterm labor: one syndrome, many causes. Science 2014; 345 (6198): 760–5. doi: 10.1126/science.1251816. Epub 2014 Aug 14.
12. Romero R, Hassan SS, Gajer P et al. The vaginal microbiota of pregnant women who subsequently have spontaneous preterm labor and delivery and those with a normal delivery at term. J Microbiome 2014; 2: 18.
13. Kim YM, Chaemsaithong P, Romero R et al. The Frequency of Acute Atherosis in Normal Pregnancy and Preterm Labor, Preeclampsia, Small for Gestational Age, Fetal Death and Midtrimester Spontaneous Abortion. J Matern Fetal Neonatal Med 2014; p. 1–24.
14. McCubbin K, Moore S, MacDonald R, Vaillancourt C. Medical Transfer of Patients in Preterm Labor: Treatments and Tocolytics. Prehosp Emerg Care 2014.
15. Mandrykina Zh.A., Menzhinskaia I.V., Ozerova R.I. i dr. Autosensibilizatsiia k gormonam pri nevynashivanii beremennosti. Akusherstvo i ginekologiia. 2009; 6: 14–6. [in Russian]
16. Yuce O, Bicer OS, Kavuncuoglu S et al. Prematurity, infection, mortality, morbidity and interleukins: the reason or the result of preterm labor? Minerva Pediatr 2014; 66 (6): 563–70.
Авторы
Ю.Э.Доброхотова, Л.С.Джохадзе*, Ю.В.Копылова
ГБОУ ВПО Российский национальный исследовательский медицинский университет им. Н.И.Пирогова Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1
*Anton-b1@mail.ru
N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1
*Anton-b1@mail.ru
ГБОУ ВПО Российский национальный исследовательский медицинский университет им. Н.И.Пирогова Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1
*Anton-b1@mail.ru
________________________________________________
N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1
*Anton-b1@mail.ru
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