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Влияние препаратов для локального применения, содержащих глюкокортикоиды, на показатели местного иммунитета и активность вируса папилломы человека
иммунитета и активность вируса папилломы человека. Гинекология. 2017; 19 (2): 66–68.
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Borovkova E.I., Fedotova A.S. Effect of local preparations containing glucocorticoids on local immunity parameters and activity of human papillomavirus. Gynecology. 2017; 19 (2): 66–68.
Материалы доступны только для специалистов сферы здравоохранения. Авторизуйтесь или зарегистрируйтесь.
Ключевые слова: неспецифический вагинит, вирус папилломы человека, местный иммунитет.
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The aim of the study was to investigate the effects of topical application of preparations containing glucocorticoids on the replicative activity of human papillomavirus oncogenic type. Prospective study included 160 patients of reproductive age. The examination included microbiological testing, qualitative and quantitative screening for human papilloma virus high-risk group (HPV-PCR and Digene-test), immunological study of cervical secret (immunoglobulins class A, M, G and secretory IgA). Was shown that the vaginal microbiocenosis in patients with nonspecific vaginitis presents a wide range of opportunistic microorganisms, such as Staphylococcus, Streptococcus, Peptostreptococcus, Bacteroides, Bacillus, Actinomyces, Corynebacterium, Prevotella. A number of typical representatives of the indigenous microflora is significantly reduced, or absent. The prevalence of concomitant viral infection was approximately 29%, the most frequently detected viruses 16, 31 and 18. The use of local therapy drug containing a glucocorticoid qualitative and quantitative changes in HPV have been no identified. Evaluation of indicators of local immunity showed an imbalance in the production of immunoglobulins with a predominance of IgA, secretory IgA and IgG in patients on the background of nonspecific vaginitis.
Key words: nonspecific vaginitis, human papillomavirus, local immunity.
2. Winer RL, Feng Q, Hughes JP et al. Risk of female human papillomavirus acquisition associated with first male sex partner. J Infect Dis 2008; 197: 279.
3. Widdice LE, Brown DR, Bernstein DI et al. Prevalence of human papillomavirus infection in young women receiving the first quadrivalent vaccine dose. Arch Pediatr Adolesc Med 2012; 166: 774.
4. Markowitz LE, Sternberg M, Dunne EF et al. Seroprevalence of human papillomavirus types 6, 11, 16, and 18 in the United States: National Health and Nutrition Examination Survey 2003-2004. J Infect Dis 2009; 200: 1059.
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2. Winer RL, Feng Q, Hughes JP et al. Risk of female human papillomavirus acquisition associated with first male sex partner. J Infect Dis 2008; 197: 279.
3. Widdice LE, Brown DR, Bernstein DI et al. Prevalence of human papillomavirus infection in young women receiving the first quadrivalent vaccine dose. Arch Pediatr Adolesc Med 2012; 166: 774.
4. Markowitz LE, Sternberg M, Dunne EF et al. Seroprevalence of human papillomavirus types 6, 11, 16, and 18 in the United States: National Health and Nutrition Examination Survey 2003-2004. J Infect Dis 2009; 200: 1059.
5. Liu G, Markowitz LE, Hariri S et al. Seroprevalence of 9 Human Papillomavirus Types in the United States, 2005-2006. J Infect Dis 2016; 213: 191.
6. Sycuro LK, Xi LF, Hughes JP et al. Persistence of genital human papillomavirus infection in a long-term follow-up study of female university students. J Infect Dis 2008; 198: 971.
1. ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И.Пирогова» Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1;
2. Клиника «Чайка». 123317, Россия, Москва, Пресненская наб., д. 8, стр. 1
*katyanikitina@mail.ru
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E.I.Borovkova*1, A.S.Fedotova2
1. N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1;
2. Clinic “Chayka”. 123317, Russian Federation, Moscow, Presnenskaia nab., d. 8, str. 1
*katyanikitina@mail.ru