1. Бабичев В.Н. Нейроэндокринная регуляция репродуктивной системы. Пущино, 1995. / Babichev V.N. Neiroendokrinnaia reguliatsiia reproduktivnoi sistemy. Pushchino, 1995. [in Russian]
2. Бабичев В.Н. Нейроэндокринология пола. М.: Наука, 1981. / Babichev V.N. Neiroendokrinologiia pola. M.: Nauka, 1981. [in Russian]
3. Вилков Г.А., Нестеренко Э.Н., Колмакова Т.С. и др. Гормональные взаимоотношения при симптоматической эпилепсии. Журн. неврологии и психиатрии. 1994; 94 (4): 6–9. / Vilkov G.A., Nesterenko E.N., Kolmakova T.S. i dr. Gormonal'nye vzaimootnosheniia pri simptomaticheskoi epilepsii. Zhurn. nevrologii i psikhiatrii. 1994; 94 (4): 6–9. [in Russian]
4. Власов П.Н. Алгоритмы диагностики и терапии эпилепсии у взрослых в поликлинических условиях. Фарматека. 2005; 7: 96–104. / Vlasov P.N. Algoritmy diagnostiki i terapii epilepsii u vzroslykh v poliklinicheskikh usloviiakh. Farmateka. 2005; 7: 96–104. [in Russian]
5. Власов П.Н. Медикаментозная терапия – основа реабилитации больных эпилепсией женщин. В кн.: Актуальные вопросы медицинской нейрореабилитации. М., 1996. / Vlasov P.N. Medikamentoznaia terapiia – osnova reabilitatsii bol'nykh epilepsiei zhenshchin. V kn.: Aktual'nye voprosy meditsinskoi neiroreabilitatsii. M., 1996. [in Russian]
6. Власов П.Н. Некоторые клинические, социальные, гормональные, ЭЭГ и терапевтические особенности эпилепсии у женщин. В кн.: Успехи современной неврологии. М.: МГМСУ, 1999. / Vlasov P.N. Nekotorye klinicheskie, sotsial'nye, gormonal'nye, EEG i terapevticheskie osobennosti epilepsii u zhenshchin. V kn.: Uspekhi sovremennoi nevrologii. M.: MGMSU, 1999. [in Russian]
7. Гехт А.Б., Авакян Г.Н., Гусев Е.И. Современные стандарты диагностики и лечения эпилепсии в Европе. Журн. неврологии и психиатрии. 1999; 7: 4–7. / Gekht A.B., Avakian G.N., Gusev E.I. Sovremennye standarty diagnostiki i lecheniia epilepsii v Evrope. Zhurn. nevrologii i psikhiatrii. 1999; 7: 4–7. [in Russian]
8. Гусев Е.И., Белоусов Ю.Б., Гехт А.В. и др. Лечение эпилепсии: рациональное дозирование антиконвульсантов. СПб., 2000. / Gusev E.I., Belousov Iu.B., Gekht A.V. i dr. Lechenie epilepsii: ratsional'noe dozirovanie antikonvul'santov. SPb., 2000. [in Russian]
9. Зенков Л.Р. Как улучшить лечение эпилепсии в России? Рос. мед. журн. 2003; 1: 3–9. / Zenkov L.R. Kak uluchshit' lechenie epilepsii v Rossii? Ros. med. zhurn. 2003; 1: 3–9. [in Russian]
10. Илловайская И.А. Актуальные проблемы нейроэндокринологии. М., 2003. / Illovaiskaia I.A. Aktual'nye problemy neiroendokrinologii. M., 2003. [in Russian]
11. Карлов В.А. Судорожный эпилептический статус. М.: МЕДпресс-информ, 2003. / Karlov V.A. Sudorozhnyi epilepticheskii status. M.: MEDpress-inform, 2003. [in Russian]
12. Карлов В.А., Власов П.Н. Беременность и лекарственная терапия эпилепсии. Новости эпилепсии. 1997; 2 (12): 6–7. / Karlov V.A., Vlasov P.N. Beremennost' i lekarstvennaia terapiia epilepsii. Novosti epilepsii. 1997; 2 (12): 6–7. [in Russian]
13. Розен В.Б., Смирнов А.Н. Рецепторы и стероидные гормоны. М.: МГУ, 1981. / Rozen V.B., Smirnov A.N. Retseptory i steroidnye gormony. M.: MGU, 1981. [in Russian]
14. Семичева Т.В. Заместительная терапия гипоталамо-гипофизарной недостаточности. М., 2001. / Semicheva T.V. Zamestitel'naia terapiia gipotalamo-gipofizarnoi nedostatochnosti. M., 2001. [in Russian]
15. Уварова Е.В. Патогенетические аспекты и современные возможности коррекции гиперандрогенных проявлений у девочек-подростков. Лечащий врач. 2008; 3: 34–42. / Uvarova E.V. Patogeneticheskie aspekty i sovremennye vozmozhnosti korrektsii giperandrogennykh proiavlenii u devochek-podrostkov. Lechashchii vrach. 2008; 3: 34–42. [in Russian]
16. Филатова Н.В. Особенности эпилепсии у женщин с нарушением менструальной функции. Автореф. дис. ... канд. мед. наук. М., 2010. / Filatova N.V. Osobennosti epilepsii u zhenshchin s narusheniem menstrual'noi funktsii. Avtoref. dis. ... kand. med. nauk. M., 2010. [in Russian]
17. Цаллагова Е.В., Прилепская В.Н. Роль снижения избыточной массы тела в восстановлении функции репродуктивной системы женщины. Гинекология. 2005; 7 (1): 51–3. / Tsallagova E.V., Prilepskaia V.N. Rol' snizheniia izbytochnoi massy tela v vosstanovlenii funktsii reproduktivnoi sistemy zhenshchiny. Gynecology. 2005; 7 (1): 51–3. [in Russian]
18. Юдаев Н.А. Биохимия гормонов и гормональной регуляции. М.: Наука, 1976. / Yudaev N.A. Biokhimiia gormonov i gormonal'noi reguliatsii. M.: Nauka, 1976. [in Russian]
19. Arimatsu Y, Hatanaka H. Estrogen treatment enhances survival of cultured fetal rat amygdala neurons in a defined medium. Dev Brain Res 1986; 26: 151–9.
20. Barrett-Connor E, Kritz-Silversten D. Estrogen replacement therapy and cognitive function in older women. JAMA 1993; 269: 2637–41.
21. Bauer J, Burr W, Elger CE. Seizure occurrence during ovulatory and anovulatory cycles in patients with temporal lobe epilepsy: a prospective study. Eur J Neurol 1988; 5 (1): 83–8.
22. Bauer J, Jarre A, Klingmuller D et al. Polycystic ovary syndrome in patients with focal epilepsy: a study in 93 women. Epilepsy Res 2000; 41: 163–7. 
23. Bonucelli U, Melis GB, Paoletti AM et al. Unbalanced progesterone and estradiol secretion in catamenial epilepsy. Epilepsy Res 1989; 3: 100–6.
24. Corpéchot C, Robel P, Axelson M et al. Characterization and measurement of dehydroepiandrosterone sulfate in rat brain. Proc Natl Acad Sci USA 1981; 78 (8): 4704–7. 
25. Crivello JF, Jefcoate J. Intracellular movement of cholesterol in rat adrenal cellc. Kinetics and effects of inhibitors. J Biol Chem 1980; 255 (17): 8144.
26. Duncan S, Brodie MJ. Sexual function in women with epilepsy. Epilepsia 1997; 38: 1074–81.
27. Flood JF, Smith GE, Roberts E. Dehydroepiandrosterone and its sulfate enhance memory retention in mice. Brain Res 1988; 447 (2): 269–78. 
28. Gee KW, Chang WC, Brinton RE et al. GABA-dependent modulation of the C1-ionophre by steroids in rat brain. Eur J Pharmacol 1987; 136 (3): 419–23.
29. Hamed SA. Neuroendocrine hormonal conditions in epilepsy: relationship to reproductive and sexual functions. Neurologist 2008; 14: 157–69.
30. Herzog AG, Friedman MN. Menstrual cycle interval and ovulation in women with localization-related epilepsy. Neurology 2001; 57: 2133–5.
31. Herzog AG. Three pattern of catamenial epilepsy. Epilepsia 1997; 38 (10): 1082–8.
32. Herzog AG, Seibel MM, Schomer DL et al. Reproductive endocrine disorders in women with partial seizures of temporal lobe origin. Arch Neurol 1986; 43: 341–6.
33. Isojarvi JIT. Serum steroids hormones and pituitary function in femail epileptic patients during carbazepine. Amer Neurol 1989; 46: 1175–8.
34. Karceski S, Morrell MJ, Carpenter D. Treatment of epilepsy in adults: expert opinion. Epilepsy Behav 2005; 7 (1): 64.
35. Karlov VA, Vlasov PN, Kuschlinsky NE et al. Syndrome of lactorrea and epilepsy. Epilepsia 1998; 39 (2): 113.
36. Kimura D. Sex differences in the brain. Sci Amer 1992; 267: 119–25.
37. Li PK, Rhodes ME, Jagannathan S. Reversal of scopolamine induced amnesia in rats by the steroid sulfatase inhibitor estrone-3-O-sulfamate. Brain Res Cogn Brain Res 1995; 2 (4): 251–4.
38. Löfgren E, Mikkonen K, Tolonen U et al. Reproductive endocrine function in women with epilepsy: the role of epilepsy type and medication. Epilepsy Behav 2007; 10 (1): 77–83.
39. Mahesh VB, Brann DW. Regulation of the preovulatory gonadotropin surge by endogenous steroids. Steroids 1998; 63: 616–29.
40. McEwen BS, Alves SE. Estrogen actions in the central nervous system. Endocr Rew 1999; 20: 279–307.
41. Ming X, Kaplan PW. Fixation-off and eyes closed catamenial generalized nonconvulsive status epilepticus with eyelid myoclonic jerks. Epilepsia 1998; 39 (6): 664–8.
42. Morrell MJ, Hayes FJ. High incidence of components of polycystic ovary syndrome in young women with epilepsy treated with valproate versus lamotrigine. Epilepsia 2005; 46 (8): 88.
43. Morrell MJ, Sperling MR, Stecker M. Sexual dysfunction in partial epilepsy: a deficit in physiologic sexual arousal. Neurology 1994; 44: 243–7.
44. Murialdo G, Galimberti CA, Magri F. Menstrual cycle and ovary alterations in women with epilepsy on antiepileptic therapy. J Endocrinol Invest 1997; 20: 519–26.
45. Ohno Y, Yanagibashi K. A possible role of “steroidogenic factor” in the corticoidogenic response to ACTH; effect of ACTH, cycloheximide and aminoglutethimide on the content of cholesterol in the outer and inner mitochondrial membrane of rat adrenal cortex. Endocrinol Jap 1983; 30 (3): 335.
46. Privalle CT, Crivello JF, Jefcoate CR. Regulation of intramitochondrial cholesterol transfer to side-chain cleavage cytochrome P450 in rat adrenal gland. Mol Cell Endocrinol 1987; 53: 87.
47. Pschirrer ER. Seizure disorders in pregnancy. Obstet Gynecol Clin North Am 2004; 31 (2): 373–84.
48. Quigg M, Kiely JM, Shneker B et al. Interictal and postictal alterations of pulsatile secretions of luteinizing hormone in temporal lobe epilepsy in men. Ann Neurol 2002; 51: 559–66.
49. Rainey WE, Nakamura Y. Regulation of the adrenal androgen biosynthesis. J Steroid Biochem Mol Biol 2008; 108 (Iss. 3–5): 281–6.
50. Tuveri A, Paoletti AM, Orru M et al. Reduced serum level of THDOC, an anticonvulsant steroid, in women with perimenstrual catamenial epilepsy. Epilepsia 2008; 49: 1221–9.

________________________________________________

1. Babichev V.N. Neiroendokrinnaia reguliatsiia reproduktivnoi sistemy. Pushchino, 1995. [in Russian]
2. Babichev V.N. Neiroendokrinologiia pola. M.: Nauka, 1981. [in Russian]
3. Vilkov G.A., Nesterenko E.N., Kolmakova T.S. i dr. Gormonal'nye vzaimootnosheniia pri simptomaticheskoi epilepsii. Zhurn. nevrologii i psikhiatrii. 1994; 94 (4): 6–9. [in Russian]
4. Vlasov P.N. Algoritmy diagnostiki i terapii epilepsii u vzroslykh v poliklinicheskikh usloviiakh. Farmateka. 2005; 7: 96–104. [in Russian]
5. Vlasov P.N. Medikamentoznaia terapiia – osnova reabilitatsii bol'nykh epilepsiei zhenshchin. V kn.: Aktual'nye voprosy meditsinskoi neiroreabilitatsii. M., 1996. [in Russian]
6. Vlasov P.N. Nekotorye klinicheskie, sotsial'nye, gormonal'nye, EEG i terapevticheskie osobennosti epilepsii u zhenshchin. V kn.: Uspekhi sovremennoi nevrologii. M.: MGMSU, 1999. [in Russian]
7. Gekht A.B., Avakian G.N., Gusev E.I. Sovremennye standarty diagnostiki i lecheniia epilepsii v Evrope. Zhurn. nevrologii i psikhiatrii. 1999; 7: 4–7. [in Russian]
8. Gusev E.I., Belousov Iu.B., Gekht A.V. i dr. Lechenie epilepsii: ratsional'noe dozirovanie antikonvul'santov. SPb., 2000. [in Russian]
9. Zenkov L.R. Kak uluchshit' lechenie epilepsii v Rossii? Ros. med. zhurn. 2003; 1: 3–9. [in Russian]
10. Illovaiskaia I.A. Aktual'nye problemy neiroendokrinologii. M., 2003. [in Russian]
11. Karlov V.A. Sudorozhnyi epilepticheskii status. M.: MEDpress-inform, 2003. [in Russian]
12. Karlov V.A., Vlasov P.N. Beremennost' i lekarstvennaia terapiia epilepsii. Novosti epilepsii. 1997; 2 (12): 6–7. [in Russian]
13. Rozen V.B., Smirnov A.N. Retseptory i steroidnye gormony. M.: MGU, 1981. [in Russian]
14. Semicheva T.V. Zamestitel'naia terapiia gipotalamo-gipofizarnoi nedostatochnosti. M., 2001. [in Russian]
15. Uvarova E.V. Patogeneticheskie aspekty i sovremennye vozmozhnosti korrektsii giperandrogennykh proiavlenii u devochek-podrostkov. Lechashchii vrach. 2008; 3: 34–42. [in Russian]
16. Filatova N.V. Osobennosti epilepsii u zhenshchin s narusheniem menstrual'noi funktsii. Avtoref. dis. ... kand. med. nauk. M., 2010. [in Russian]
17. Tsallagova E.V., Prilepskaia V.N. Rol' snizheniia izbytochnoi massy tela v vosstanovlenii funktsii reproduktivnoi sistemy zhenshchiny. Gynecology. 2005; 7 (1): 51–3. [in Russian]
18. Yudaev N.A. Biokhimiia gormonov i gormonal'noi reguliatsii. M.: Nauka, 1976. [in Russian]
19. Arimatsu Y, Hatanaka H. Estrogen treatment enhances survival of cultured fetal rat amygdala neurons in a defined medium. Dev Brain Res 1986; 26: 151–9.
20. Barrett-Connor E, Kritz-Silversten D. Estrogen replacement therapy and cognitive function in older women. JAMA 1993; 269: 2637–41.
21. Bauer J, Burr W, Elger CE. Seizure occurrence during ovulatory and anovulatory cycles in patients with temporal lobe epilepsy: a prospective study. Eur J Neurol 1988; 5 (1): 83–8.
22. Bauer J, Jarre A, Klingmuller D et al. Polycystic ovary syndrome in patients with focal epilepsy: a study in 93 women. Epilepsy Res 2000; 41: 163–7. 
23. Bonucelli U, Melis GB, Paoletti AM et al. Unbalanced progesterone and estradiol secretion in catamenial epilepsy. Epilepsy Res 1989; 3: 100–6.
24. Corpéchot C, Robel P, Axelson M et al. Characterization and measurement of dehydroepiandrosterone sulfate in rat brain. Proc Natl Acad Sci USA 1981; 78 (8): 4704–7. 
25. Crivello JF, Jefcoate J. Intracellular movement of cholesterol in rat adrenal cellc. Kinetics and effects of inhibitors. J Biol Chem 1980; 255 (17): 8144.
26. Duncan S, Brodie MJ. Sexual function in women with epilepsy. Epilepsia 1997; 38: 1074–81.
27. Flood JF, Smith GE, Roberts E. Dehydroepiandrosterone and its sulfate enhance memory retention in mice. Brain Res 1988; 447 (2): 269–78. 
28. Gee KW, Chang WC, Brinton RE et al. GABA-dependent modulation of the C1-ionophre by steroids in rat brain. Eur J Pharmacol 1987; 136 (3): 419–23.
29. Hamed SA. Neuroendocrine hormonal conditions in epilepsy: relationship to reproductive and sexual functions. Neurologist 2008; 14: 157–69.
30. Herzog AG, Friedman MN. Menstrual cycle interval and ovulation in women with localization-related epilepsy. Neurology 2001; 57: 2133–5.
31. Herzog AG. Three pattern of catamenial epilepsy. Epilepsia 1997; 38 (10): 1082–8.
32. Herzog AG, Seibel MM, Schomer DL et al. Reproductive endocrine disorders in women with partial seizures of temporal lobe origin. Arch Neurol 1986; 43: 341–6.
33. Isojarvi JIT. Serum steroids hormones and pituitary function in femail epileptic patients during carbazepine. Amer Neurol 1989; 46: 1175–8.
34. Karceski S, Morrell MJ, Carpenter D. Treatment of epilepsy in adults: expert opinion. Epilepsy Behav 2005; 7 (1): 64.
35. Karlov VA, Vlasov PN, Kuschlinsky NE et al. Syndrome of lactorrea and epilepsy. Epilepsia 1998; 39 (2): 113.
36. Kimura D. Sex differences in the brain. Sci Amer 1992; 267: 119–25.
37. Li PK, Rhodes ME, Jagannathan S. Reversal of scopolamine induced amnesia in rats by the steroid sulfatase inhibitor estrone-3-O-sulfamate. Brain Res Cogn Brain Res 1995; 2 (4): 251–4.
38. Löfgren E, Mikkonen K, Tolonen U et al. Reproductive endocrine function in women with epilepsy: the role of epilepsy type and medication. Epilepsy Behav 2007; 10 (1): 77–83.
39. Mahesh VB, Brann DW. Regulation of the preovulatory gonadotropin surge by endogenous steroids. Steroids 1998; 63: 616–29.
40. McEwen BS, Alves SE. Estrogen actions in the central nervous system. Endocr Rew 1999; 20: 279–307.
41. Ming X, Kaplan PW. Fixation-off and eyes closed catamenial generalized nonconvulsive status epilepticus with eyelid myoclonic jerks. Epilepsia 1998; 39 (6): 664–8.
42. Morrell MJ, Hayes FJ. High incidence of components of polycystic ovary syndrome in young women with epilepsy treated with valproate versus lamotrigine. Epilepsia 2005; 46 (8): 88.
43. Morrell MJ, Sperling MR, Stecker M. Sexual dysfunction in partial epilepsy: a deficit in physiologic sexual arousal. Neurology 1994; 44: 243–7.
44. Murialdo G, Galimberti CA, Magri F. Menstrual cycle and ovary alterations in women with epilepsy on antiepileptic therapy. J Endocrinol Invest 1997; 20: 519–26.
45. Ohno Y, Yanagibashi K. A possible role of “steroidogenic factor” in the corticoidogenic response to ACTH; effect of ACTH, cycloheximide and aminoglutethimide on the content of cholesterol in the outer and inner mitochondrial membrane of rat adrenal cortex. Endocrinol Jap 1983; 30 (3): 335.
46. Privalle CT, Crivello JF, Jefcoate CR. Regulation of intramitochondrial cholesterol transfer to side-chain cleavage cytochrome P450 in rat adrenal gland. Mol Cell Endocrinol 1987; 53: 87.
47. Pschirrer ER. Seizure disorders in pregnancy. Obstet Gynecol Clin North Am 2004; 31 (2): 373–84.
48. Quigg M, Kiely JM, Shneker B et al. Interictal and postictal alterations of pulsatile secretions of luteinizing hormone in temporal lobe epilepsy in men. Ann Neurol 2002; 51: 559–66.
49. Rainey WE, Nakamura Y. Regulation of the adrenal androgen biosynthesis. J Steroid Biochem Mol Biol 2008; 108 (Iss. 3–5): 281–6.
50. Tuveri A, Paoletti AM, Orru M et al. Reduced serum level of THDOC, an anticonvulsant steroid, in women with perimenstrual catamenial epilepsy. Epilepsia 2008; 49: 1221–9.

Е.В.Цаллагова1, В.О.Генералов*2, Т.Р.Садыков2, В.В.Боровкова1

1. ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова» Минздрава России. 117997, Россия, Москва, ул. Академика Опарина, д. 4;
2. Центр диагностики и лечения эпилепсии «Планета Мед». 117105, Россия, Москва, Варшавское ш., д. 13
*videoeeg@mail.ru

________________________________________________

E.V.Tsallagova1, V.O.Generalov*1, T.R.Sadykov2, V.V.Borovkova1

1. V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4;
2. Center of diagnostics and treatment for epilepsy “Planeta Med”. 117105, Russian Federation, Moscow, Varshavskoe sh., d. 13
*videoeeg@mail.ru