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Дефицит витамина D: современный подход к патогенезу и терапии
Дефицит витамина D: современный подход к патогенезу и терапии
Ломова Н.А., Карапетян Т.Э., Долгополова Е.Л., Мальбахова Е.Т. Дефицит витамина D: современный подход к патогенезу и терапии. Гинекология. 2018; 20 (5): 68–70.
DOI: 10.26442/2079-5696_2018.5.68-70
20 (5): 68–70.
DOI: 10.26442/2079-5696_2018.5.68-70
DOI: 10.26442/2079-5696_2018.5.68-70
________________________________________________
20 (5): 68–70.
DOI: 10.26442/2079-5696_2018.5.68-70
Материалы доступны только для специалистов сферы здравоохранения. Авторизуйтесь или зарегистрируйтесь.
Аннотация
Во время беременности и грудного вскармливания возрастают потребности организма женщины. Пищевые вещества, поступающие в организм, используются как для питания материнского организма, так и для построения органов (структур) плода и его жизнеобеспечения. Дефицитные состояния способствуют развитию различных акушерских осложнений, патологическому течению беременности и родов, неблагоприятно влияют на формирование плаценты, передачу через нее микронутриентов от матери к ребенку, повышают риск развития дефицитных состояний у ребенка, нарушений ранней неонатальной адаптации и формирования отклонений в состоянии здоровья детей на этапе постнатального онтогенеза. Ежедневная добавка витамина D на протяжении всей беременности несет профилактический эффект и может снижать риск развития преэклампсии, эндотелиальной дисфункции, гестационного сахарного диабета, преждевременных родов, неонатальной гипокальциемии.
Ключевые слова: витамин D, профилактика, акушерские и неонатальные осложнения, эндотелиальная дисфункция, дефицитные состояния.
Key words: vitamin D, prevention, obstetric and neonatal complications, endothelial dysfunction, deficit states.
Ключевые слова: витамин D, профилактика, акушерские и неонатальные осложнения, эндотелиальная дисфункция, дефицитные состояния.
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Key words: vitamin D, prevention, obstetric and neonatal complications, endothelial dysfunction, deficit states.
Полный текст
Список литературы
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2. Royal College of Obstetricians and Gynecologists. Nutrition in pregnancy. Scientific Advisory Committee Opinion Paper 18. September 2010. Available from: http://www.rcog.org.uk/
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13. Maghbooli Z, Hossein-Nezhad A, Karimi F et al. Correlation between vitamin D3 deficiency and insulin resistance in pregnancy. Diabetes Metab Res Rev 2008; 24: 27–32.
14. Lacroix M, Battista MC, Doyon M et al. Lower vitamin D levels at first trimester are associated with higher risk of developing gestational diabetes mellitus. Acta Diabetol 2014.
15. Scholl TO, Chen X, Stein P. Maternal vitamin D status and delivery by cesarean. Nutrients 2012; 4: 319–30.
16. Zhou J, Su L, Liu M et al. Associations between 25-hydroxyvitamin D levels and pregnancy outcomes: a prospective observational study in southern China. Eur J Clin Nutr 2014.
17. Harvey N, Holroyd C, Ntani G et al. Vitamin D supplementation in pregnancy: a systematic review. Health Technol Assess 2014; 18: 1–190.
18. De-Regil LM, Palacios C, Lombardo LK et al. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev 2016.
19. Roth DE, Leung M, Mesfin E et al. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. Br Med J 2017; 359: j5237.
20. Grant CC, Stewart AW, Scragg R et al. Vitamin D during pregnancy and infancy and infant serum 25-hydroxyvitamin D concentration. Pediatrics 2013.
21. Marya RK, Rathee S, Lata V et al. Effects of vitamin D supplementation in pregnancy. Gynecol Obstet Invest 1981; 12: 155–61.
22. Hashemipour S, Lalooha F, Zahir Mirdamadi S et al. Effect of vitamin D administration in vitamin D-deficient pregnant women on maternal and neonatal serum calcium and vitamin D concentrations: a randomised clinical trial. Br J Nutr 2013; 110: 1611–6.
2. Royal College of Obstetricians and Gynecologists. Nutrition in pregnancy. Scientific Advisory Committee Opinion Paper 18. September 2010. Available from: http://www.rcog.org.uk/
3. Scientific Advisory Committee on Nutrition: Vitamin D and Health. London: The Stationary Office, 2016.
4. Arundel P, Ahmed SF, Allgrove J et al. British Paediatric and Adolescent Bone Group’s position statement on vitamin D deficiency. Br Med J 2012; 345: e8182.
5. Holick MF. The D-lightful vitamin D for child health. JPEN J Parenter Enteral Nutr 2012; 36 (Suppl. 1): 9S–19S. DOI: 10.1177/0148607111430189
6. Urashima M, Segawa T, Okazaki M et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr 2010; 91 (5): 1255–60. DOI: 10.3945/ajcn.2009.29094
7. Pulver AE, McGrath JA, Liang KY et al. An indirect test of the new mutation hypothesis associating advanced paternal age with the etiology of schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2004; 124B (1): 6–9.
8. Hofmeyr GJ, Lawrie TA, Atallah AN et al. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev 2014; 6: Cd001059.
9. Al Mheid I, Patel R, Murrow J et al. Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans. J Am Coll Cardiol 2011; 58: 18692.
10. Schulz EV, Cruze L, Wei W et al. Maternal vitamin D sufficiency and reduced placental gene expression in angiogenic biomarkers related to comorbidities of pregnancy. J Steroid Biochem Mol Biol 2017; 173: 273–9.
11. Bodnar LM, Catov JM, Simhan HN et al. Maternal vitamin D deficiency increases the risk of preeclampsia. J Clin Endocrinol Metab 2007; 92: 3517–22.
12. Asemi Z, Hashemi T, Karamali M et al. Effects of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation, and oxidative stress in gestational diabetes: a double-blind randomized controlled clinical trial. Am J Clin Nutr 2013; 98: 1425–32.
13. Maghbooli Z, Hossein-Nezhad A, Karimi F et al. Correlation between vitamin D3 deficiency and insulin resistance in pregnancy. Diabetes Metab Res Rev 2008; 24: 27–32.
14. Lacroix M, Battista MC, Doyon M et al. Lower vitamin D levels at first trimester are associated with higher risk of developing gestational diabetes mellitus. Acta Diabetol 2014.
15. Scholl TO, Chen X, Stein P. Maternal vitamin D status and delivery by cesarean. Nutrients 2012; 4: 319–30.
16. Zhou J, Su L, Liu M et al. Associations between 25-hydroxyvitamin D levels and pregnancy outcomes: a prospective observational study in southern China. Eur J Clin Nutr 2014.
17. Harvey N, Holroyd C, Ntani G et al. Vitamin D supplementation in pregnancy: a systematic review. Health Technol Assess 2014; 18: 1–190.
18. De-Regil LM, Palacios C, Lombardo LK et al. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev 2016.
19. Roth DE, Leung M, Mesfin E et al. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. Br Med J 2017; 359: j5237.
20. Grant CC, Stewart AW, Scragg R et al. Vitamin D during pregnancy and infancy and infant serum 25-hydroxyvitamin D concentration. Pediatrics 2013.
21. Marya RK, Rathee S, Lata V et al. Effects of vitamin D supplementation in pregnancy. Gynecol Obstet Invest 1981; 12: 155–61.
22. Hashemipour S, Lalooha F, Zahir Mirdamadi S et al. Effect of vitamin D administration in vitamin D-deficient pregnant women on maternal and neonatal serum calcium and vitamin D concentrations: a randomised clinical trial. Br J Nutr 2013; 110: 1611–6.
2. Royal College of Obstetricians and Gynecologists. Nutrition in pregnancy. Scientific Advisory Committee Opinion Paper 18. September 2010. Available from: http://www.rcog.org.uk/
3. Scientific Advisory Committee on Nutrition: Vitamin D and Health. London: The Stationary Office, 2016.
4. Arundel P, Ahmed SF, Allgrove J et al. British Paediatric and Adolescent Bone Group’s position statement on vitamin D deficiency. Br Med J 2012; 345: e8182.
5. Holick MF. The D-lightful vitamin D for child health. JPEN J Parenter Enteral Nutr 2012; 36 (Suppl. 1): 9S–19S. DOI: 10.1177/0148607111430189
6. Urashima M, Segawa T, Okazaki M et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr 2010; 91 (5): 1255–60. DOI: 10.3945/ajcn.2009.29094
7. Pulver AE, McGrath JA, Liang KY et al. An indirect test of the new mutation hypothesis associating advanced paternal age with the etiology of schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2004; 124B (1): 6–9.
8. Hofmeyr GJ, Lawrie TA, Atallah AN et al. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev 2014; 6: Cd001059.
9. Al Mheid I, Patel R, Murrow J et al. Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans. J Am Coll Cardiol 2011; 58: 18692.
10. Schulz EV, Cruze L, Wei W et al. Maternal vitamin D sufficiency and reduced placental gene expression in angiogenic biomarkers related to comorbidities of pregnancy. J Steroid Biochem Mol Biol 2017; 173: 273–9.
11. Bodnar LM, Catov JM, Simhan HN et al. Maternal vitamin D deficiency increases the risk of preeclampsia. J Clin Endocrinol Metab 2007; 92: 3517–22.
12. Asemi Z, Hashemi T, Karamali M et al. Effects of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation, and oxidative stress in gestational diabetes: a double-blind randomized controlled clinical trial. Am J Clin Nutr 2013; 98: 1425–32.
13. Maghbooli Z, Hossein-Nezhad A, Karimi F et al. Correlation between vitamin D3 deficiency and insulin resistance in pregnancy. Diabetes Metab Res Rev 2008; 24: 27–32.
14. Lacroix M, Battista MC, Doyon M et al. Lower vitamin D levels at first trimester are associated with higher risk of developing gestational diabetes mellitus. Acta Diabetol 2014.
15. Scholl TO, Chen X, Stein P. Maternal vitamin D status and delivery by cesarean. Nutrients 2012; 4: 319–30.
16. Zhou J, Su L, Liu M et al. Associations between 25-hydroxyvitamin D levels and pregnancy outcomes: a prospective observational study in southern China. Eur J Clin Nutr 2014.
17. Harvey N, Holroyd C, Ntani G et al. Vitamin D supplementation in pregnancy: a systematic review. Health Technol Assess 2014; 18: 1–190.
18. De-Regil LM, Palacios C, Lombardo LK et al. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev 2016.
19. Roth DE, Leung M, Mesfin E et al. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. Br Med J 2017; 359: j5237.
20. Grant CC, Stewart AW, Scragg R et al. Vitamin D during pregnancy and infancy and infant serum 25-hydroxyvitamin D concentration. Pediatrics 2013.
21. Marya RK, Rathee S, Lata V et al. Effects of vitamin D supplementation in pregnancy. Gynecol Obstet Invest 1981; 12: 155–61.
22. Hashemipour S, Lalooha F, Zahir Mirdamadi S et al. Effect of vitamin D administration in vitamin D-deficient pregnant women on maternal and neonatal serum calcium and vitamin D concentrations: a randomised clinical trial. Br J Nutr 2013; 110: 1611–6.
________________________________________________
2. Royal College of Obstetricians and Gynecologists. Nutrition in pregnancy. Scientific Advisory Committee Opinion Paper 18. September 2010. Available from: http://www.rcog.org.uk/
3. Scientific Advisory Committee on Nutrition: Vitamin D and Health. London: The Stationary Office, 2016.
4. Arundel P, Ahmed SF, Allgrove J et al. British Paediatric and Adolescent Bone Group’s position statement on vitamin D deficiency. Br Med J 2012; 345: e8182.
5. Holick MF. The D-lightful vitamin D for child health. JPEN J Parenter Enteral Nutr 2012; 36 (Suppl. 1): 9S–19S. DOI: 10.1177/0148607111430189
6. Urashima M, Segawa T, Okazaki M et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr 2010; 91 (5): 1255–60. DOI: 10.3945/ajcn.2009.29094
7. Pulver AE, McGrath JA, Liang KY et al. An indirect test of the new mutation hypothesis associating advanced paternal age with the etiology of schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2004; 124B (1): 6–9.
8. Hofmeyr GJ, Lawrie TA, Atallah AN et al. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev 2014; 6: Cd001059.
9. Al Mheid I, Patel R, Murrow J et al. Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans. J Am Coll Cardiol 2011; 58: 18692.
10. Schulz EV, Cruze L, Wei W et al. Maternal vitamin D sufficiency and reduced placental gene expression in angiogenic biomarkers related to comorbidities of pregnancy. J Steroid Biochem Mol Biol 2017; 173: 273–9.
11. Bodnar LM, Catov JM, Simhan HN et al. Maternal vitamin D deficiency increases the risk of preeclampsia. J Clin Endocrinol Metab 2007; 92: 3517–22.
12. Asemi Z, Hashemi T, Karamali M et al. Effects of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation, and oxidative stress in gestational diabetes: a double-blind randomized controlled clinical trial. Am J Clin Nutr 2013; 98: 1425–32.
13. Maghbooli Z, Hossein-Nezhad A, Karimi F et al. Correlation between vitamin D3 deficiency and insulin resistance in pregnancy. Diabetes Metab Res Rev 2008; 24: 27–32.
14. Lacroix M, Battista MC, Doyon M et al. Lower vitamin D levels at first trimester are associated with higher risk of developing gestational diabetes mellitus. Acta Diabetol 2014.
15. Scholl TO, Chen X, Stein P. Maternal vitamin D status and delivery by cesarean. Nutrients 2012; 4: 319–30.
16. Zhou J, Su L, Liu M et al. Associations between 25-hydroxyvitamin D levels and pregnancy outcomes: a prospective observational study in southern China. Eur J Clin Nutr 2014.
17. Harvey N, Holroyd C, Ntani G et al. Vitamin D supplementation in pregnancy: a systematic review. Health Technol Assess 2014; 18: 1–190.
18. De-Regil LM, Palacios C, Lombardo LK et al. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev 2016.
19. Roth DE, Leung M, Mesfin E et al. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. Br Med J 2017; 359: j5237.
20. Grant CC, Stewart AW, Scragg R et al. Vitamin D during pregnancy and infancy and infant serum 25-hydroxyvitamin D concentration. Pediatrics 2013.
21. Marya RK, Rathee S, Lata V et al. Effects of vitamin D supplementation in pregnancy. Gynecol Obstet Invest 1981; 12: 155–61.
22. Hashemipour S, Lalooha F, Zahir Mirdamadi S et al. Effect of vitamin D administration in vitamin D-deficient pregnant women on maternal and neonatal serum calcium and vitamin D concentrations: a randomised clinical trial. Br J Nutr 2013; 110: 1611–6.
Авторы
Н.А.Ломова*1, Т.Э.Карапетян1, Е.Л.Долгополова1, Е.Т.Мальбахова2
1. ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова» Минздрава России. 117997, Россия, Москва, ул. Академика Опарина, д. 4;
2. Клиника «Мать и дитя» Савеловская. 127015, Россия, Москва, ул. Бутырская, д. 46
*n_lomova@oparina4.ru
1. V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4;
2. Clinic "Mother and child" Savelovskaya. 127015, Russian Federation, Moscow, ul. Butyrskaia, d. 46
*n_lomova@oparina4.ru
1. ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова» Минздрава России. 117997, Россия, Москва, ул. Академика Опарина, д. 4;
2. Клиника «Мать и дитя» Савеловская. 127015, Россия, Москва, ул. Бутырская, д. 46
*n_lomova@oparina4.ru
________________________________________________
1. V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4;
2. Clinic "Mother and child" Savelovskaya. 127015, Russian Federation, Moscow, ul. Butyrskaia, d. 46
*n_lomova@oparina4.ru
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