Витамин D3 и здоровье женщины

Доброхотова Ю.Э., Боровкова Е.И., Залесская С.А. и др. Витамин D3 и здоровье женщины. Гинекология. 2019; 21 (1): 44–51.
DOI: 10.26442/20795696.2019.1.190235

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Dobrokhotova Yu.E., Borovkova E.I., Zalesskaya S.A. et al. Vitamin D3 and women's health. Gynecology. 2019; 21 (1): 44–51.
DOI: 10.26442/20795696.2019.1.190235

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Аннотация

Обоснование. Витамин D является важным компонентом, регулирующим кальциевый гомеостаз и многие другие клеточные функции. Гиповитаминоз D ассоциирован с риском развития остеопении, ожирения, сахарного диабета 1 и 2-го типа, злокачественных новообразований и иммунных нарушений. Недостаточное потребление витамина во время беременности повышает риск развития преэклампсии, преждевременных родов, рождения маловесных новорожденных, а также оказывает негативное влияние на здоровье детей и подростков. Клиницисту важно ориентироваться в профилактических и терапевтических схемах назначения препаратов витамина D в зависимости от сывороточного уровня 25(ОН)D.
Цель. Установить причины и последствия развития дефицита витамина D и определить способы их коррекции.
Материалы и методы. Для написания обзора был осуществлен поиск отечественных и зарубежных публикаций в российских и международных системах поиска (PubMed, eLibrary и пр.) за последние 2–15 лет. В обзор были включены статьи из рецензируемой литературы.
Результаты. В работе показано, что витамин D оказывает значительное влияние на функционирование органов сердечно-сосудистой, эндокринной, пищеварительной, дыхательной и других систем, а также на перинатальные исходы, что обусловливает необходимость коррекции дефицита витамина. Представлены схемы расчета эффективной лечебной и профилактической доз лекарственных средств в зависимости от концентрации витамина D3 в сыворотке крови.
Заключение. Предпочтение должно отдаваться холекальциферолу (витамин D3) в связи с его лучшими абсорбционными свойствами и более эффективным преобразованием в активные метаболиты витамина (класс IIC).

Ключевые слова: гиповитаминоз D, холекальциферол, коррекция дефицита витамина.

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Background. Vitamin D is an essential component that regulates calcium homeostasis and many other cellular functions. Hypovitaminosis D is associated with a risk of osteopenia, obesity, type 1 and type 2 diabetes, malignant neoplasms and immune disorders. Inadequate vitamin D intake during pregnancy increases a risk of pre-eclampsia, preterm birth, low birth weight as well as it has a negative impact on both children’s and adolescents’ health. It is important for the clinician to be known administrating of vitamin D prophylactic and therapeutic regimens according to serum 25(OH)D levels.
Aim. To determine causes and effects of vitamin D deficiency and to elaborate ways of their correction.
Materials and methods. To write this review a search for domestic and foreign publications in Russian and international search systems (PubMed, eLibrary, etc.) for the last 2–15 years was conducted. The review includes articles from peer-reviewed literature.
Results. The article shows that vitamin D has a significant impact on both the cardiovascular, endocrine, digestive, respiratory and other systems functioning and perinatal outcomes that necessitates vitamin D deficiency correction. It provides schemes for effective therapeutic and prophylactic drug doses calculating depending on vitamin D3 blood serum concentration.
Conclusion. Preference should be given to cholecalciferol (vitamin D3) due to its better absorption properties and more efficient conversion to active vitamin metabolites (class IIC).

Key words: hypovitaminosis D, cholecalciferol, correction of vitamin deficiency.

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Авторы

Ю.Э.Доброхотова1, Е.И.Боровкова*1, С.А.Залесская1, В.С.Скальная2, И.М.Боровков3, З.С.Зайдиева2

1. ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И.Пирогова» Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1;
2. ГБУЗ «Городская клиническая больница №40» Департамента здравоохранения г. Москвы. 129301, Россия, Москва, ул. Касаткина, д. 7;
3. ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М.Сеченова» Минздрава России. 119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2
*katyanikitina@mail.ru

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Iuliia E. Dobrokhotova1, Ekaterina I. Borovkova*1, Sofya A. Zalesskaya1, Victoria S. Skalnaya2, Ivan M. Borovkov3, Zulya S. Zaydieva2

1. N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 1, Ostrovitianova st., Moscow, 117997, Russian Federation;
2. City Clinical Hospital №40 of the Department of Health of Moscow. 7, Kasatkina st., Moscow, 129301, Russian Federation;
3. I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation. 2, 8, Trubetskaia st., Moscow, 119991, Russian Federation
*katyanikitina@mail.ru

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