Метастатическое поражение головного мозга у больных раком шейки матки встречается крайне редко. Появление интракраниальных метастазов является отсроченным нежелательным явлением и признаком неблагоприятного прогноза. В данной работе мы представляем случай метастатического поражения головного мозга при раке шейки матки с проведенным комплексным лечением и длительной безрецидивной выживаемостью пациентки.
Brain metastases from uterine cervical carcinoma are very rare. The development of intracranial metastases is a long-term adverse event indicating poor prognosis. In this paper, we present a case of cervical cancer with a brain metastasis in a patient who received combination therapy and demonstrated long-term progression-free survival.
1. Аксель Е.М., Виноградова Н.Н. Статистика злокачественных новообразований женских репродуктивных органов. Онкогинекология. 2018; 3: 64–78.
[Aksel' E.M., Vinogradova N.N. Statistika zlokachestvennykh novoobrazovanii zhenskikh reproduktivnykh organov. Onkoginekologiia. 2018; 3: 64–78 (in Russian).]
2. Бохман Я.В. Руководство по онкогинекологии. СПб.: Фолиант, 2002; с. 195–229.
[Bokhman Ia.V. Guide to gynecological oncology. Saint Petersburg: Foliant, 2002; p. 195–229 (in Russian).]
3. Гончарук И.В., Воробьева Л.И., Неспрядько С.В., Пузырная И.Н. Ретроспективный анализ больных с рецидивами и метастазами рака шейки матки. Сб. материалов VII съезда онкологов России. М., 2009; с. 2.
[Goncharuk I.V., Vorob'eva L.I., Nespriad'ko S.V., Puzyrnaia I.N. Retrospective analysis of patients with relapses and metastases of cervical cancer. Sb. materialov VII s'ezda onkologov Rossii. Moscow, 2009; p. 2 (in Russian).]
4. Kumar L, Tanwar RK, Singh SP. Intracranial metastasis from carcinoma cervix and review of literature. Gynecol Oncol 1992; 46: 391–2.
5. Chura JC, Shukla K, Argenta PA. Brain metastasis from cervical carcinoma Int J Gynecol Cancer 2007; 17: 141–6.
6. Park SH, Ro DY, Park BJ et al. Brain metastasis from uterine cervical cancer. J Obstet Gynaecol Res 2010; 36: 701–4.
7. Andrew J, Baker JM. Cerebral metastasis from cervical carcinoma. J Obstet Gynecol Br Emp 1953; 60: 545–9.
8. Buchsbaum HJ, Rice AC. Cerebral metastasis in cervical carcinoma. Am J Obstet Gynecol 1972; 114: 276–8.
9. Cormio G, Pellegrino A, Landoni F. Brain metastasis from cervical carcinoma. Tumori 1996; 82: 394–6.
10. Cormio G, Colamaria A, Loverro G. Surgical resection of a cerebral metastasis from cervical cancer: case report and review of literature. Tumori 1999; 85: 65–7.
11. Ditzel LF, Pereira CU, Arajo JC. Cerebral metastasis of cervical uterine cancer. Neuropsiquiatr 2006; 64 (2-A): 300–2.
12. Friedman M, Nissenbaum M, Lakier R et al. Brain metastasis in early cancer of uterine cervix. South Afr Med J 1983; 64: 488–9.
13. Kaleigh F, Dibson D G, Jose M et al. Cervical cancer metastasis to the brain: A case report and review of literature. Surg Neurol Int 2017; 8: 181.
14. Branch BC, Henry J, Vecil GG. Brain metastases from cervical cancer – A short review. Tumori 2014; 100: 171–9.
15. Chung SB, Jo KI, Seol HJ et al. Radiosurgery to palliate symptoms in brain metastases from uterine cervix cancer. Acta Neurochir 2013; 155: 399–405.
16. Hwang JH, Yoo HJ, Lim MC et al. Brain metastasis in patients with uterine cervical cancer. J Obstet Gynaecol Res 2013; 39: 287–91.
17. Sato Y, Tanaka K, Kobayashi Y et al. Uterine cervical cancer with brain metastasis as the initial site of presentation. J Obstet Gynaecol Res 2015; 41: 1145–8.
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1. Aksel' E.M., Vinogradova N.N. Statistika zlokachestvennykh novoobrazovanii zhenskikh reproduktivnykh organov. Onkoginekologiia. 2018; 3: 64–78 (in Russian).
2. Bokhman Ia.V. Guide to gynecological oncology. Saint Petersburg: Foliant, 2002; p. 195–229 (in Russian).
3. Goncharuk I.V., Vorob'eva L.I., Nespriad'ko S.V., Puzyrnaia I.N. Retrospective analysis of patients with relapses and metastases of cervical cancer. Sb. materialov VII s'ezda onkologov Rossii. Moscow, 2009; p. 2 (in Russian).
4. Kumar L, Tanwar RK, Singh SP. Intracranial metastasis from carcinoma cervix and review of literature. Gynecol Oncol 1992; 46: 391–2.
5. Chura JC, Shukla K, Argenta PA. Brain metastasis from cervical carcinoma Int J Gynecol Cancer 2007; 17: 141–6.
6. Park SH, Ro DY, Park BJ et al. Brain metastasis from uterine cervical cancer. J Obstet Gynaecol Res 2010; 36: 701–4.
7. Andrew J, Baker JM. Cerebral metastasis from cervical carcinoma. J Obstet Gynecol Br Emp 1953; 60: 545–9.
8. Buchsbaum HJ, Rice AC. Cerebral metastasis in cervical carcinoma. Am J Obstet Gynecol 1972; 114: 276–8.
9. Cormio G, Pellegrino A, Landoni F. Brain metastasis from cervical carcinoma. Tumori 1996; 82: 394–6.
10. Cormio G, Colamaria A, Loverro G. Surgical resection of a cerebral metastasis from cervical cancer: case report and review of literature. Tumori 1999; 85: 65–7.
11. Ditzel LF, Pereira CU, Arajo JC. Cerebral metastasis of cervical uterine cancer. Neuropsiquiatr 2006; 64 (2-A): 300–2.
12. Friedman M, Nissenbaum M, Lakier R et al. Brain metastasis in early cancer of uterine cervix. South Afr Med J 1983; 64: 488–9.
13. Kaleigh F, Dibson D G, Jose M et al. Cervical cancer metastasis to the brain: A case report and review of literature. Surg Neurol Int 2017; 8: 181.
14. Branch BC, Henry J, Vecil GG. Brain metastases from cervical cancer – A short review. Tumori 2014; 100: 171–9.
15. Chung SB, Jo KI, Seol HJ et al. Radiosurgery to palliate symptoms in brain metastases from uterine cervix cancer. Acta Neurochir 2013; 155: 399–405.
16. Hwang JH, Yoo HJ, Lim MC et al. Brain metastasis in patients with uterine cervical cancer. J Obstet Gynaecol Res 2013; 39: 287–91.
17. Sato Y, Tanaka K, Kobayashi Y et al. Uterine cervical cancer with brain metastasis as the initial site of presentation. J Obstet Gynaecol Res 2015; 41: 1145–8.
1. ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
2. ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России, Москва, Россия
*hope-sev@yandex.ru
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Nadezhda V. Sevyan*1,2, Vladislav B. Karakhan2, Ali Kh. Bekyashev2, David R. Naskhletashvili2, Nikolai A. Kozlov2, Evgeniy V. Prozorenko1, Dmitriy M. Belov2, Dmitry E. Aftomonov1, Alexey A. Mitrofanov2, Marina V. Lomaya1, Lala T. Mamedova2, Boris I. Polyakov1
1. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia;
2. Blokhin National Medical Research Center of Oncology, Moscow, Russia
*hope-sev@yandex.ru