Дискуссионные вопросы клинической, лабораторной и инструментальной диагностики опухолей яичников у женщин репродуктивного возраста (обзор литературы)

1. Ortiz-Muñoz B, Aznar-Oroval E, García García A et al. HE4, Ca125 and ROMA algorithm for differential diagnosis between benign gynaecological diseases and ovarian cancer. Tumour Biol 2014; 35 (7): 7249–58. DOI: 10.1007/s13277-014-1945-6
2. Борисова Е.А. Комплексная дифференциальная диагностика опухолей придатков матки. Автореф. дис. … канд. мед. наук. Иркутск, 2018.
 [Borisova E.A. Kompleksnaia differentsial'naia diagnostika opukholei pridatkov matki. Avtoref. dis. … kand. med. nauk. Irkutsk, 2018 (in Russian).]
3. Серебренникова К.Г., Кузнецова Е.П. Хирургическое лечение доброкачественных опухолей яичников. Фундаментальные исследования. 2011; 9 (1): 155–8.
 [Serebrennikova K.G., Kuznetsova E.P. Khirurgicheskoe lechenie dobrokachestvennykh opukholei iaichnikov. Fundamental'nye issledovaniia. 2011; 9 (1): 155–8 (in Russian).]
4. Каприн А.Д., Старинский В.В., Петрова Г.В. Состояние онкологической помощи населению России в 2017 году. М.: МНИОИ им. П.А. Герцена – филиал ФГБУ «НМИЦ радиологии» Минздрава России, 2018.
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5. Ferlay J, Soerjomataram I, Dikshit R et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015; 136 (5): E359–86. DOI: 10.1002/ijc.29210
6. Zola P, Macchi C, Cibula D et al. Follow-up in Gynecological Malignancies A State of Art. Int J Gyn Cancer 2015; 25 (7): 1151–64. DOI: 10.1097/igc.0000000000000498
7. Committee Opinion No. 716. American College of Obstetricians and Gynecologists. The role of the obstetrician-gynecologist in the early detection of epithelial ovarian cancer in women at average risk. Obstet Gynecol 2017; 130: e146–9.
8. Orr B, Edwards RP. Diagnosis and Treatment of Ovarian Cancer. Hematol Oncol Clin North Am 2018; 32 (6): 943–64. DOI: 10.1016/j.hoc.2018.07.010
9. Воробьев А.В., Протасова А.Э. Общие вопросы скрининга. Практическая онкология. 2010; 11 (2): 53–9.
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10. Антошечкина М.А., Савинова Е.Б. Иcпользование биомаркеров для ранней диагностики рака яичников. Кремлевская медицина. Клинический вестник. 2011; 4: 91–3.
 [Antoshechkina M.A., Savinova E.B. Icpol'zovanie biomarkerov dlia rannei diagnostiki raka iaichnikov. Kremlevskaia meditsina. Klinicheskii vestnik. 2011; 4: 91–3 (in Russian).]
11. Ефимова О.А. Комплексная лучевая диагностика опухолевых образований яичников на дооперационном этапе. Поволжский онкологический вестн. 2017; 3 (30): 61–4.
 [Efimova O.A. Kompleksnaia luchevaia diagnostika opukholevykh obrazovanii iaichnikov na dooperatsionnom etape. Povolzhskii onkologicheskii vestn. 2017; 3 (30): 61–4 (in Russian).]
12. Силина И.А. Рак яичника: аспекты диагностики. Лабораторная диагностика. Восточная Европа. 2015; 3–4 (15–16): 159–68.
 [Silina I.A. Rak iaichnika: aspekty diagnostiki. Laboratornaia diagnostika. Vostochnaia Evropa. 2015; 3–4 (15–16): 159–68 (in Russian).]
13. Батырова Л.М. Ранняя диагностика рака яичников. Вестник хирургии Казахстана. 2011; 2: 46–7.
 [Batyrova L.M. Ranniaia diagnostika raka iaichnikov. Vestnik khirurgii Kazakhstana. 2011; 2: 46–7 (in Russian).]
14. Мехдиев В.Э. Клиническое значение трехмерной трансвагинальной эхографии в режиме цветного и энергетического Доплера в дифференциальной диагностике опухолей и опухолевидных образований яичников. Автореф. дис. … канд. мед. наук. М., 2011.
 [Mekhdiev V.E. Klinicheskoe znachenie trekhmernoi transvaginal'noi ekhografii v rezhime tsvetnogo i energeticheskogo Doplera v differentsial'noi diagnostike opukholei i opukholevidnykh obrazovanii iaichnikov. Avtoref. dis. … kand. med. nauk. M., 2011 (in Russian).]
15. Ionescu CA, Matei A, Navolan D et al. Correlation of ultrasound features and the Risk of Ovarian Malignancy Algorithm score for different histopathological subtypes of benign adnexal masses. Medicine (Baltimore) 2018; 97 (31): e11762. DOI: 10.1097/MD.0000000000011762
16. Querleu D, Planchamp F, Chiva L et al. European Society of Gynaecological Oncology (ESGO) Guidelines for Ovarian Cancer Surgery. Int J Gynecol Cancer 2017; 27 (7): 1534–42. DOI: 10.1097/IGC.0000000000001041
17. Gold P, Freedman S. Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J Exp Med 1965; 121: 439–62. DOI: 10.1084/jem.121.3.439
18. Hammarstrom S, Engvall E, Sundblad G. Carcinoembryonic antigen CEA: purification, structure and antigenicproperties, in Health Control in Detection of Cancer, Skandia International Symposia. Bostrom H, Larsson T, Ljungstedt N, eds. 1976; p. 24–39.
19. Khoo S, MacKay E. Carcinoembryonic antigen (CEA) in ovarian cancer: Factors influencing its incidence and changes which occur in response to cytotoxic drugs. Br J Obstet Gynaecol 1976; 83: 753–9. DOI: 10.1111/j.1471-0528.1976.tb00739.x
20. Bast R, Feeney M, Lazarus H et al. Reactivity of a monoclonal antibody with human ovarian carcinoma. J Clin Investig 1981; 68: 1331–7. DOI: 10.1172/JCI110380
21. Агаджанян К.В., Устьянцева И.М., Петухова О.В., Яковлева Н.В. Клинико-метаболические изменения в зависимости от степени тяжести эндометриоза: материалы III Международного конгресса по репродуктивной медицине «Проблемы репродукции». М., 2009; c. 163.
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22. Li F, Tie R, Chang K et al. Meta-analysis Does risk for ovarian malignancy algorithm excel human epididymis protein 4 and CA125 in predicting epithelial ovarian cancer: A meta-analysis. BMC Cancer 2012; 12: 258. DOI: 10.1186/1471-2407-12-258
23. Moore RG, McMeekin DS, Brown AK et al. A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass. Gynecol Oncol 2009; 112: 40–6.
24. Kim YM, Whang DH, Park J et al. Evaluation of the accuracy of serum human epididymis protein 4 in combination with CA125 for detecting ovarian cancer: a prospective casecontrol study in a Korean population. Clin Chem Lab Med 2011; 49: 527–34.
25. Galgano MT, Hampton GM, Frierson HFJr. Comprehensive analysis of HE4 expression in normal and malignant human tissues. Mod Pathol 2006; 19: 847–53.
26. Capriglione S, Luvero D, Plotti F et al. Ovarian cancer recurrence and early detection: may HE4 play a key role in this open challenge? A systematic review of literature. Med Oncol 2017; 34 (9): 164. DOI: 10.1007/s12032-017-1026-y
27. Chen F, Shen J, Wang J et al. Clinical analysis of four serum tumor markers in 458 patients with ovarian tumors: diagnostic value of the combined use of HE4, CA125, CA19-9, and CEA in ovarian tumors. Cancer Manag Res 2018; 10: 1313–8. DOI: 10.2147/CMAR.S155693
28. Simmons AR, Clarke CH, Badgwell DB et al. Validation of a Biomarker Panel and Longitudinal Biomarker Performance for Early Detection of Ovarian Cancer. Int J Gynecol Cancer 2016; 26 (6): 1070–7. DOI: 10.1097/IGC.0000000000000737
29. Ueland F, DeSimone C, Seamon L et al. Effectiveness of a multivariate index assay in the preoperative assessment of ovarian tumors. Obstet Gynecol 2011; 117: 1289–97. DOI: 10.1097/AOG.0b013e31821b5118
30. Zhang Z, Chan D. The road from discovery to clinical diagnostics: Lessons learned from the first FDA-cleared in vitro diagnostic multivariate index assay of proteomic biomarkers. Cancer Epidemiol Biomark Prev 2010; 19: 2995–9. DOI: 10.1158/1055-9965.EPI-10-0580
31. Meys EM, Kaijser J, Kruitwagen RF et al. Subjective assessment versus ultrasound models to diagnose ovarian cancer: A systematic review and meta-analysis. Eur J Cancer 2016; 58: 17–29. DOI: 10.1016/j.ejca.2016.01.007
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36. Макаров О.В., Нариманова М.Р., Мошковский С.А., Карпова М.А. Перспектива нового способа своевременной диагностики рака яичников на основе использования комбинации сывороточных белков СА125 и SAA-A1. Акушерство и гинекология. 2015; 3: 48–57.
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37. Герфанова Е.В., Ашрафян Л.А., Антонова И.Б. и др. Скрининг рака яичников: реальность и перспективы. Обзор литературы. Опухоли женской репродуктивной системы. 2015; 11 (1): 69–75.
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40. Sehgal N. Efficacy of Color Doppler Ultrasonography in Differentiation of Ovarian Masses. J Midlife Health 2019; 10 (1): 22–8. DOI: 10.4103/jmh.JMH_23_18
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43. Moro F, Pasciuto T, Djokovic D et al. Role of CA125/CEA ratio and ultrasound parameters in identifying metastases to the ovaries in patients with multilocular and multilocular-solid ovarian masses. Ultrasound Obstet Gynecol 2019; 53 (1): 116–23. DOI: 10.1002/uog.19174
44. Wynants L, Timmerman D, Verbakel JY et al. Clinical Utility of Risk Models to Refer Patients with Adnexal Masses to Specialized Oncology Care: Multicenter External Validation Using Decision Curve Analysis. Clin Cancer Res 2017; 23 (17): 5082–90. DOI: 10.1158/1078-0432.CCR-16-3248
45. Подзолкова Н.М., Львова А.Г., Зубарев А.Р., Осадчев В.Б. Дифференциальная диагностика опухолей и опухолевидных образований яичников: клиническое значение трехмерной эхографии. Вопросы гинекологии, акушерства и перинатологии. 2009; 8 (1): 7–16.
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46. Братчикова О.В. Новые технологии (3D/4D-УЗИ) в определении характера яичниковых образований. Автореф. дис. … канд. мед. наук. М., 2011.
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47. Ашрафян Л.А., Ивашина С.В., Когай Н.В. и др. Возможности соноэластометрии для дифференциальной диагностики доброкачественных и злокачественных опухолей яичников. Опухоли женской репродуктивной системы. 2012; 2.
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48. Henri M, Florence E, Aurore B et al. Contribution of contrast-enhanced ultrasound with Sonovue to describe the microvascularization of uterine fibroid tumors before and after uterine artery embolization. Eur J Obstet Gynecol Reprod Biol 2014; 181: 104–10. DOI: 10.1016/j.ejogrb.2014.07.030
49. Ma X, Zhao Y, Zhang B et al. Contrast-enhanced ultrasound for differential diagnosis of malignant and benign ovarian tumors: systematic review and meta-analysis. Ultrasound Obstet Gynecol 2015; 46 (3): 277–83. DOI: 10.1002/uog.14800
50. Meng W, Ying W, Qichao Z et al. Clinical value of combining transvaginal contrast-enhanced ultrasonography with serum human epididymisprotein-4 and the resistance index for early-stage epithelial ovarian cancer. Saudi Med J 2017; 38 (6): 592–7. DOI: 10.15537/smj.2017.6.19790
51. Liu Z, Yang F, Zhang Y et al. Conventional, Doppler and Contrast-Enhanced Ultrasonography in Differential Diagnosis of Ovarian Masses. Cell Physiol Biochem 2016; 39 (6): 2398–408.
52. Агеев А.С., Чекалова М.А., Патютко Ю.И. Ультразвуковое исследование с контрастным усилением в диагностике метастатического поражения печени. Ультразвуковая и функциональная диагностика. 2016; 2: 9–16.
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1. Ortiz-Muñoz B, Aznar-Oroval E, García García A et al. HE4, Ca125 and ROMA algorithm for differential diagnosis between benign gynaecological diseases and ovarian cancer. Tumour Biol 2014; 35 (7): 7249–58. DOI: 10.1007/s13277-014-1945-6
2. Borisova E.A. Kompleksnaia differentsial'naia diagnostika opukholei pridatkov matki. Avtoref. dis. … kand. med. nauk. Irkutsk, 2018 (in Russian).
3. Serebrennikova K.G., Kuznetsova E.P. Khirurgicheskoe lechenie dobrokachestvennykh opukholei iaichnikov. Fundamental'nye issledovaniia. 2011; 9 (1): 155–8 (in Russian).
4. Kaprin A.D., Starinsky V.V., Petrova G.V. The status of cancer care for the population of Russia in 2017. Moscow: MNIOI im. P.A. Gertsena – filial FGBU "NMITs radiologii' Minzdrava Rossii, 2018 (in Russian).
5. Ferlay J, Soerjomataram I, Dikshit R et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015; 136 (5): E359–86. DOI: 10.1002/ijc.29210
6. Zola P, Macchi C, Cibula D et al. Follow-up in Gynecological Malignancies A State of Art. Int J Gyn Cancer 2015; 25 (7): 1151–64. DOI: 10.1097/igc.0000000000000498
7. Committee Opinion No. 716. American College of Obstetricians and Gynecologists. The role of the obstetrician-gynecologist in the early detection of epithelial ovarian cancer in women at average risk. Obstet Gynecol 2017; 130: e146–9.
8. Orr B, Edwards RP. Diagnosis and Treatment of Ovarian Cancer. Hematol Oncol Clin North Am 2018; 32 (6): 943–64. DOI: 10.1016/j.hoc.2018.07.010
9. Vorob'ev A.V., Protasova A.E. Obshchie voprosy skrininga. Prakticheskaia onkologiia. 2010; 11 (2): 53–9 (in Russian).
10. Antoshechkina M.A., Savinova E.B. Icpol'zovanie biomarkerov dlia rannei diagnostiki raka iaichnikov. Kremlevskaia meditsina. Klinicheskii vestnik. 2011; 4: 91–3 (in Russian).
11. Efimova O.A. Kompleksnaia luchevaia diagnostika opukholevykh obrazovanii iaichnikov na dooperatsionnom etape. Povolzhskii onkologicheskii vestn. 2017; 3 (30): 61–4 (in Russian).
12. Silina I.A. Rak iaichnika: aspekty diagnostiki. Laboratornaia diagnostika. Vostochnaia Evropa. 2015; 3–4 (15–16): 159–68 (in Russian).
13. Batyrova L.M. Ranniaia diagnostika raka iaichnikov. Vestnik khirurgii Kazakhstana. 2011; 2: 46–7 (in Russian).
14. Mekhdiev V.E. Klinicheskoe znachenie trekhmernoi transvaginal'noi ekhografii v rezhime tsvetnogo i energeticheskogo Doplera v differentsial'noi diagnostike opukholei i opukholevidnykh obrazovanii iaichnikov. Avtoref. dis. … kand. med. nauk. M., 2011 (in Russian).
15. Ionescu CA, Matei A, Navolan D et al. Correlation of ultrasound features and the Risk of Ovarian Malignancy Algorithm score for different histopathological subtypes of benign adnexal masses. Medicine (Baltimore) 2018; 97 (31): e11762. DOI: 10.1097/MD.0000000000011762
16. Querleu D, Planchamp F, Chiva L et al. European Society of Gynaecological Oncology (ESGO) Guidelines for Ovarian Cancer Surgery. Int J Gynecol Cancer 2017; 27 (7): 1534–42. DOI: 10.1097/IGC.0000000000001041
17. Gold P, Freedman S. Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J Exp Med 1965; 121: 439–62. DOI: 10.1084/jem.121.3.439
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Н.М. Подзолкова*, В.Б. Осадчев, К.В. Бабков, Н.Е. Сафонова
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия
*podzolkova@gmail.com

________________________________________________

Nataliia M. Podzolkova*, Vasilii B. Osadchev, Kirill V. Babkov, Natalia E. Safonova

Russian Medical Academy of Continuous Professional Education, Moscow, Russia
*podzolkova@gmail.com