Генитальный герпес: современные представления и перспективы лечения

1. Patel R, Kennedy OJ, Clarke E et al. 2017 European guidelines for the management of genital herpes. Int J STD AIDS 2017; 28 (14): 1366–79. DOI: 10.1177/0956462417727194.
2. Исаков В.А., Сафонова М.М., Семенова А.Е. Медико-социальное значение и современная терапия генитального герпеса. Intl J Immunorehabilitation 1996; 2: 11.
[Isakov V.A., Safonova M.M., Semenova A.E. Mediko-sotsial'noe znachenie i sovremennaia terapiia genital'nogo gerpesa. Intl J Immunorehabilitation 1996; 2: 11 (in Russian).]
3. Gnann JWJr, Whitley RJ. Clinical practice. Genital herpes. N Engl J Med 2016; 375 (7): 666–74. DOI: 10.1056/NEJMcp1603178
4. Johnston C, Corey L. Current Concepts for Genital Herpes Simplex Virus Infection: Diagnostics and Pathogenesis of Genital Tract Shedding. Clin Microbiol Rew 2016; 29 (1): 1496–1.
5. Groves MJ. Genital Herpes: A Review. Am Fam Physician 2016; 93 (11): 928–34.
6. Hofstetter AM, Rosenthal SL, Stanberry LR. Current thinking on genital herpes. Curr Opin Infect Dis 2014; 27 (1): 75–83. DOI: 10.1097/QCO.0000000000000029
7. Roett MA, Mayor MT, Uduhiri KA. Diagnosis and management of genital ulcers. Am Fam Physician 2012; 85 (3): 254–62.
8. Centers for Disease Control and Prevention. Guidelines for treatment of sexually transmitted diseases. MMWR, 2015.
9. Murray PR, Rosenthal KS, Pfaller MA. Medical Microbiology. 5th. Elsevier Mosby, 2005. 
10. Looker KJ, Garnett GP, Schmid GP. An estimate of the global prevalence and incidence of herpes simplex virus type 2 infection. Bull World Health Organ 2008; 86: 805–12. 
11. Федеральные клинические рекомендации. Дерматовенерология 2015: Болезни кожи. Инфекции, передаваемые половым путем. 5-е изд, перераб. и доп. М.: Деловой экспресс, 2016.
[Federal clinical guidelines. Dermatovenereology 2015: Skin diseases. Sexually transmitted infections. 5th ed., rev. and add. Moscow: Business Express, 2016 (in Russian).]
12. Хрянин А.А., Решетников О.В., Кандрушина М.П. Многолетние тенденции в распространенности вируса простого герпеса в популяции Сибири. Вестн. дерматологии и венерологии. 2010; 5: 96–101.
[Khrianin A.A., Reshetnikov O.V., Kandrushina M.P. Mnogoletnie tendentsii v rasprostranennosti virusa prostogo gerpesa v populiatsii Sibiri. Vestn. dermatologii i venerologii. 2010; 5: 96–101 (in Russian).] 
13. Львов А.Л., Халдин А.А., Маркова Ю.А. Современные возможности контроля течения рецидивирующего простого герпеса и ассоциированных с ним психосоматических расстройств. Рос. журн. кожных и венерических болезней. Герпес. 2009; 2: 54–6.
[L'vov A.L., Khaldin A.A., Markova Iu.A. Sovremennye vozmozhnosti kontrolia techeniia retsidiviruiushchego prostogo gerpesa i assotsiirovannykh s nim psikhosomaticheskikh rasstroistv. Ros. zhurn. kozhnykh i venericheskikh boleznei. Gerpes. 2009; 2: 54–6 (in Russian).]
14. Халдин А.А., Гилядов А.Д., Быханова О.Н., Исаева Д.Р. Воспроизведенные ациклические синтетические нуклеозиды в этиотропной терапии рецидивов простого герпеса. Клин. дерматология и венерология. 2014; 2: 79–83.
[Khaldin A.A., Giliadov A.D., Bykhanova O.N., Isaeva D.R. Vosproizvedennye atsiklicheskie sinteticheskie nukleozidy v etiotropnoi terapii retsidivov prostogo gerpesa. Klin. dermatologiia i venerologiia. 2014; 2: 79–83 (in Russian).]
15. Инструкция по медицинскому применению лекарственного препарата Валвир.
[Instructions for the medical use of the drug Valvir (in Russian).]
16. Простой герпес. Цитомегаловирусная инфекция. Методические рекомендации. М., 2016. 
[Herpes simplex. Cytomegalovirus infection. Methodical recommendations. Moscow, 2016 (in Russian).]
17. Горячкина М.В., Белоусова Т.А. Эпизодическая и супрессивная терапия простого герпеса ациклическими нуклеозидами. Клин. дерматология и венерология. 2014; 4: 68–74.
[Goriachkina M.V., Belousova T.A. Epizodicheskaia i supressivnaia terapiia prostogo gerpesa atsiklicheskimi nukleozidami. Klin. dermatologiia i venerologiia. 2014; 4: 68–74 (in Russian).]
18. Орлов Е.В., Котельникова Е.В., Васильев-Ступальский Е.А. и др. Генитальный герпес: эффективность противовирусной терапии. Клин. дерматология и венерология. 2015; 3: 40–5.
[Orlov E.V., Kotel'nikova E.V., Vasil'ev-Stupal'skii E.A. et al. Genital'nyi gerpes: effektivnost' protivovirusnoi terapii. Klin. dermatologiia i venerologiia. 2015; 3: 40–5 (in Russian).]
19. Sauerbrei A. Optimal management of genital herpes: current perspectives. Infection and Drug Resistance 2016; 9: 129–41.
20. Клинические рекомендации по ведению больных с инфекциями, передаваемыми половым путем, и урогенитальными инфекциями. Рос. общество дерматовенерологов и косметологов. www.cnikvi.ru/docs/2015.
[Klinicheskie rekomendatsii po vedeniiu bol'nykh s infektsiiami, peredavaemymi polovym putem, i urogenital'nymi infektsiiami. Ros. obshchestvo dermatovenerologov i kosmetologov. www.cnikvi.ru/docs/2015 (in Russian).]
21. Инструкция по медицинскому применению лекарственного препарата Ацикловир.
[Instructions for the medical use of the drug Acyclovir (in Russian).]
22. Исаков В.А., Ермоленко Д.К., Исаков Д.В. Перспективы профилактики и лечения простого герпеса с монотонным типом рецидивирования. Терапевтический архив. 2011; 83 (11): 44–7.
[Isakov V.A., Ermolenko D.K., Isakov D.V. Perspektivy profilaktiki i lecheniia prostogo gerpesa s monotonnym tipom retsidivirovaniia. Therapeutic Archive. 2011; 83 (11): 44–7 (in Russian).]
23. Available from: https://pubmed.ncbi.nlm.nih.gov/?term=valaciclovir+
24. Fife KH, Almekinder J, Ofner S. A Comparison of One Year of Episodic or Suppressive Treatment of Recurrent Genital Herpes With Valacyclovir. Sexually Transmitted Diseases: May 2007; 34 (5): 297–301. doi: 10.1097/01.olq.0000237853.69443.71
25. Corey L, Wald A, Patel R et al. Once-daily valacyclovir to reduce the risk of transmission of genital herpes. N Engl J Med 2004; 350 (1): 11–20.
26. Leruez-Ville M, Ghout I, Bussières L et al. In utero treatment of congenital cytomegalovirus infection with valacyclovir in a multicenter, open-label, phase II study. Am J Obstet Gynecol 2016; 215 (4): 462.e1-462.e10. DOI: 10.1016/j.ajog.2016.04.003.
27. Canadian Agency for Drugs and Technologies in Health. Acyclovir versus valacyclovir for herpes virus in children and pregnant women: a review of the clinical evidence and guidelines. CADT Rapid Response Reports. 2014. 
28. Hollier LM, Wendel GD. Third trimester antiviral prophylaxis for preventing maternal genital herpes simplex virus (HSV) recurrences and neonatal herpes. Cochrane Database Syst Rev 2008; 1: CD004946.
29. Хрянин А.А., Решетников О.В. Современные перспективы лечения генитального герпеса. Мед. совет. 2019; 13: 16–22.
[Khrianin A.A., Reshetnikov O.V. Sovremennye perspektivy lecheniia genital'nogo gerpesa. Med. sovet. 2019; 13: 16–22 (in Russian).]

________________________________________________

1. Patel R, Kennedy OJ, Clarke E et al. 2017 European guidelines for the management of genital herpes. Int J STD AIDS 2017; 28 (14): 1366–79. DOI: 10.1177/0956462417727194.
2. Isakov V.A., Safonova M.M., Semenova A.E. Mediko-sotsial'noe znachenie i sovremennaia terapiia genital'nogo gerpesa. Intl J Immunorehabilitation 1996; 2: 11 (in Russian).
3. Gnann JWJr, Whitley RJ. Clinical practice. Genital herpes. N Engl J Med 2016; 375 (7): 666–74. DOI: 10.1056/NEJMcp1603178
4. Johnston C, Corey L. Current Concepts for Genital Herpes Simplex Virus Infection: Diagnostics and Pathogenesis of Genital Tract Shedding. Clin Microbiol Rew 2016; 29 (1): 1496–1.
5. Groves MJ. Genital Herpes: A Review. Am Fam Physician 2016; 93 (11): 928–34.
6. Hofstetter AM, Rosenthal SL, Stanberry LR. Current thinking on genital herpes. Curr Opin Infect Dis 2014; 27 (1): 75–83. DOI: 10.1097/QCO.0000000000000029
7. Roett MA, Mayor MT, Uduhiri KA. Diagnosis and management of genital ulcers. Am Fam Physician 2012; 85 (3): 254–62.
8. Centers for Disease Control and Prevention. Guidelines for treatment of sexually transmitted diseases. MMWR, 2015.
9. Murray PR, Rosenthal KS, Pfaller MA. Medical Microbiology. 5th. Elsevier Mosby, 2005. 
10. Looker KJ, Garnett GP, Schmid GP. An estimate of the global prevalence and incidence of herpes simplex virus type 2 infection. Bull World Health Organ 2008; 86: 805–12. 
11. Federal clinical guidelines. Dermatovenereology 2015: Skin diseases. Sexually transmitted infections. 5th ed., rev. and add. Moscow: Business Express, 2016 (in Russian).
12. Khrianin A.A., Reshetnikov O.V., Kandrushina M.P. Mnogoletnie tendentsii v rasprostranennosti virusa prostogo gerpesa v populiatsii Sibiri. Vestn. dermatologii i venerologii. 2010; 5: 96–101 (in Russian).
13. L'vov A.L., Khaldin A.A., Markova Iu.A. Sovremennye vozmozhnosti kontrolia techeniia retsidiviruiushchego prostogo gerpesa i assotsiirovannykh s nim psikhosomaticheskikh rasstroistv. Ros. zhurn. kozhnykh i venericheskikh boleznei. Gerpes. 2009; 2: 54–6 (in Russian).
14. [Khaldin A.A., Giliadov A.D., Bykhanova O.N., Isaeva D.R. Vosproizvedennye atsiklicheskie sinteticheskie nukleozidy v etiotropnoi terapii retsidivov prostogo gerpesa. Klin. dermatologiia i venerologiia. 2014; 2: 79–83 (in Russian).
15. Instructions for the medical use of the drug Valvir (in Russian).
16. Herpes simplex. Cytomegalovirus infection. Methodical recommendations. Moscow, 2016 (in Russian).
17. Goriachkina M.V., Belousova T.A. Epizodicheskaia i supressivnaia terapiia prostogo gerpesa atsiklicheskimi nukleozidami. Klin. dermatologiia i venerologiia. 2014; 4: 68–74 (in Russian).
18. Orlov E.V., Kotel'nikova E.V., Vasil'ev-Stupal'skii E.A. et al. Genital'nyi gerpes: effektivnost' protivovirusnoi terapii. Klin. dermatologiia i venerologiia. 2015; 3: 40–5 (in Russian).
19. Sauerbrei A. Optimal management of genital herpes: current perspectives. Infection and Drug Resistance 2016; 9: 129–41.
20. Klinicheskie rekomendatsii po vedeniiu bol'nykh s infektsiiami, peredavaemymi polovym putem, i urogenital'nymi infektsiiami. Ros. obshchestvo dermatovenerologov i kosmetologov. www.cnikvi.ru/docs/2015 (in Russian).
21. Instructions for the medical use of the drug Acyclovir (in Russian).
22. Isakov V.A., Ermolenko D.K., Isakov D.V. Perspektivy profilaktiki i lecheniia prostogo gerpesa s monotonnym tipom retsidivirovaniia. Therapeutic Archive. 2011; 83 (11): 44–7 (in Russian).
23. Available from: https://pubmed.ncbi.nlm.nih.gov/?term=valaciclovir+
24. Fife KH, Almekinder J, Ofner S. A Comparison of One Year of Episodic or Suppressive Treatment of Recurrent Genital Herpes With Valacyclovir. Sexually Transmitted Diseases: May 2007; 34 (5): 297–301. doi: 10.1097/01.olq.0000237853.69443.71
25. Corey L, Wald A, Patel R et al. Once-daily valacyclovir to reduce the risk of transmission of genital herpes. N Engl J Med 2004; 350 (1): 11–20.
26. Leruez-Ville M, Ghout I, Bussières L et al. In utero treatment of congenital cytomegalovirus infection with valacyclovir in a multicenter, open-label, phase II study. Am J Obstet Gynecol 2016; 215 (4): 462.e1-462.e10. DOI: 10.1016/j.ajog.2016.04.003.
27. Canadian Agency for Drugs and Technologies in Health. Acyclovir versus valacyclovir for herpes virus in children and pregnant women: a review of the clinical evidence and guidelines. CADT Rapid Response Reports. 2014. 
28. Hollier LM, Wendel GD. Third trimester antiviral prophylaxis for preventing maternal genital herpes simplex virus (HSV) recurrences and neonatal herpes. Cochrane Database Syst Rev 2008; 1: CD004946.
29. Khrianin A.A., Reshetnikov O.V. Sovremennye perspektivy lecheniia genital'nogo gerpesa. Med. sovet. 2019; 13: 16–22 (in Russian).

А.А. Хрянин*1,2, Г.Ю. Кнорринг3 

1 ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России, Новосибирск, Россия;
2 РОО «Ассоциация акушеров-гинекологов и дерматовенерологов», Новосибирск, Россия;
3 ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России, Москва, Россия
*khryanin@mail.ru

________________________________________________

Aleksey A. Khryanin*1,2, German Yu. Knorring3

1 Novosibirsk State Medical University, Novosibirsk, Russia;
2 Association of Obstetrician-Gynecologists and Dermatologists, Novosibirsk, Russia;
3 Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
*khryanin@mail.ru