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Бесплодие, ассоциированное с эндометриозом яичников: современный взгляд на проблему
Бесплодие, ассоциированное с эндометриозом яичников: современный взгляд на проблему
Оразов М.Р., Хамошина М.Б., Абитова М.З. и др. Бесплодие, ассоциированное с эндометриозом яичников: современный взгляд на проблему.
Гинекология. 2020; 22 (5): 44–49. DOI: 10.26442/20795696.2020.5.200405
Гинекология. 2020; 22 (5): 44–49. DOI: 10.26442/20795696.2020.5.200405
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Аннотация
В настоящем обзоре обобщены современные представления о патогенезе одной из самых распространенных форм наружного генитального эндометриоза – эндометриоидных кист яичников (ЭКЯ). Ввиду их частой встречаемости у молодых женщин репродуктивного возраста и крайне негативного влияния на морфофизиологическое состояние яичников данное заболевание вносит весомый вклад в структуру эндометриозассоциированного бесплодия. Основной детерминантой негативного влияния ЭКЯ на репродуктивную функцию является снижение овариального резерва, которое может происходить как из-за непосредственного гонадотоксического действия самой эндометриодной кисты, так и за счет непреднамеренного удаления здоровой овариальной ткани во время хирургического вмешательства или использования агрессивных методов электрохирургии. Отсюда дискутабельным является вопрос о методах достижения гемостаза во время операции с точки зрения ятрогенного влияния на здоровую овариальную ткань. Стратегия ведения пациенток с бесплодием, ассоциированным с эндометриозом яичников, складывается из двух составляющих: оперативное лечение и/или применение вспомогательных репродуктивных технологий. Лапароскопическая
цистэктомия показана при размере кист более 3 см. Повторные оперативные вмешательcтва по поводу эндометриоза не улучшают исходы фертильности. Методы вспомогательных репродуктивных технологий следует рассматривать в качестве первоочередной тактики у пациенток старшего репродуктивного возраста с низкими показателями овариального резерва или длительностью бесплодия более 2 лет, а также при рецидивах ЭКЯ. Ведение таких пациенток обязательно должно быть персонализированным и учитывать возраст, состояние овариального резерва, длительность бесплодия, стадию и количество оперативных вмешательств по поводу данного заболевания.
Ключевые слова: беременность, бесплодие, овариальный резерв, хирургическое лечение, эндометриоз, эндометриоидные кисты яичников.
Key words: pregnancy, infertility, ovarian reserve, surgical treatment, endometriosis, endometrioid ovarian cysts.
цистэктомия показана при размере кист более 3 см. Повторные оперативные вмешательcтва по поводу эндометриоза не улучшают исходы фертильности. Методы вспомогательных репродуктивных технологий следует рассматривать в качестве первоочередной тактики у пациенток старшего репродуктивного возраста с низкими показателями овариального резерва или длительностью бесплодия более 2 лет, а также при рецидивах ЭКЯ. Ведение таких пациенток обязательно должно быть персонализированным и учитывать возраст, состояние овариального резерва, длительность бесплодия, стадию и количество оперативных вмешательств по поводу данного заболевания.
Ключевые слова: беременность, бесплодие, овариальный резерв, хирургическое лечение, эндометриоз, эндометриоидные кисты яичников.
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Key words: pregnancy, infertility, ovarian reserve, surgical treatment, endometriosis, endometrioid ovarian cysts.
Полный текст
Список литературы
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2. Adamson GD, Kennedy S, Hummelshoj L. Creating solutions in endometriosis: global collaboration through the World Endometriosis Research Foundation. J Endometrios 2010; 2 (1): 3–6.
3. Gałczyński K, Jóźwik M, Lewkowicz D et al. Ovarian endometrioma – a possible finding in adolescent girls and young women: a mini-review.
J Ovar Res 2019; 12 (1): 104.
4. Benagiano G, Guo SW, Puttemans P et al. Progress in the diagnosis and management of adolescent endometriosis: an opinion. Reprod Bio Med Online 2018; 36: 102–14.
5. Macer ML, Taylor HS. Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility. Obstet Gynecol Clin N Am 2012; 39 (4): 535–49.
6. Orazov M.R., Radzinskiy V.E., Khamoshina M.B. et al. Treatment efficacy of infertility due to recurrent external genital endometriosis. Gynecology. 2019; 21 (1): 38–43 (in Russian).
7. Radzinskiy VE, Orazov MR, Ivanov II et al. Implantation failures in women with infertility associated endometriosis. Gynecological Endocrinology 2019; 35 (1): 27–30.
8. Evans MB, Decherney AH. Fertility and endometriosis. Clin Obstet Gynecol 2017; 60: 497–502.
9. Cranney R, Condous G, Reid S. An update on the diagnosis, surgical management, and fertility outcomes for women with endometrioma. Acta Obstet Gynecol Scand 2017; 96 (6): 633–43.
10. When more is not better: 10 don’ts in endometriosis management. An ETIC position statement. Hum Reprod Open 2019; 3: hoz009.
11. Donnez J, Nisolle M, Gillet N et al. Large ovarian endometriomas. Hum Reprod 1996; 11 (3): 641–46.
12. Vercellini P, Somigliana E, Vigano P et al. ‘Blood On The Tracks’ from corpora lutea to endometriomas. BJOG 2009; 116 (3): 366–71.
13. Hughesdon P. The structure of endometrial cysts of the ovary. J Obstet Gynaecol Br Em 1957; 64: 481–7.
14. Brosens IA, Puttemans PJ, Deprest J. The endoscopic localization of endometrial implants in the ovarian chocolate cyst. Fertil Steril 1994; 61: 1034–8.
15. Gogacz M, Gałczyński K, Wojtaś M et al. Fas-related apoptosis of peritoneal fluid macrophages in endometriosis patients: understanding the disease. J Immunol Res 2017; 2017: 3175394.
16. Ria R, Loverro A, Vacca A et al. Angiogenesis extent and expression of matrix metalloproteinase-2 and -9 agree with progression of ovarian endometriomas. Eur J Clin Invest 2002; 32 (3): 199–206.
17. Bulun SE, Yilmaz BD, Sison C et al. Endometriosis. Endocr Rev. 2019; 40 (4): 1048–79.
18. Rizner TL. Estrogen metabolism and action in endometriosis. Mol Cell Endocrinol 2009; 307 (1–2): 8–18.
19. Artymuk N.V., Guljaeva L.F., Zotova O.A. Metabolism peculiaritirs and estrogenes reception in endometrial hyperplasia and endometriosis. Mat' i ditia v Kuzbasse. 2012; 1: 8–12 (in Russian).
20. Hayashi A, Tanabe A, Kawabe S et al. Dienogest increases the progesterone receptor isoform B/A ratio in patients with ovarian endometriosis. J Ovarian Res 2012; 5 (1): 31.
21. Brosens I, Benagiano G. Clinical significance of neonatal menstruation. Eur J Obstet Gynecol Reprod Biol 2016; 196: 57–9.
22. Benagiano G, Bianchi P, Brosens I. Ovarian endometriomas in adolescents often represent active angiogenic disease requiring early diagnosis and careful management. Minerva Ginecol 2017; 69: 100–7.
23. Sanchez AM, Vigano P, Somigliana E et al. The distinguishing cellular and molecular features of the endometriotic ovarian cyst: from pathophysiology to the potential endometrioma-mediated damage to the ovary. Hum Reprod Update 2014; 20 (2): 217–30.
24. Jwabuchi T, Yoshimoto C, Shigetomi H, Kobayashi H. Oxidative stress and antioxidant defense in endometriosis and its malignant transformation. Oxid Med Cell Longev 2015; 2015: 848595.
25. Melkozerova O.A., Bashmakova N.V., Okulova E.O. Genetic and epigenetic mechanisms of infertility associated with genital endometriosis. Obstetrics and gynecology. 2019; 8: 26–32 (in Russian).
26. Ghosh AK, Vaughan DE. PAI-1 in tissue fibrosis. J Cell Physiol 2012; 227 (2): 493–507.
27. Samarakoon R, Overstreet JM, Higgings PJ. TGF-beta signaling in tissue fibro sis: redox controls, target genes and therapeutic opportunities. Cell Signal 2013; 25: 264–8.
28. Rahmioglu N, Nyholt DR, Morris AP et al. Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets. Hum Reprod Update 2014; 20 (5): 702–16.
29. Qiu JJ, Liu YL, Liu MH et al. Ovarian interstitial blood flow changes assessed by transvaginal colour Doppler sonography: predicting ovarian endometrioid cyst-induced injury to ovarian interstitial vessels. Arch Gynecol Obstet 2012; 285 (2): 427–33.
30. Maneschi F, Marasa L, Incandela S et al. Ovarian cortex surrounding benign neoplasms: a histologic study. Am J Obstet Gynecol 1993; 169: 388–93.
31. Cranney R, Condous G, Reid S. An update on the diagnosis, surgical management, and fertility outcomes for women with endometrioma. Acta Obstet Gynecol Scand 2017; 96 (6): 633–43.
32. Khine YM, Taniguchi F, Harada T. Clinical management of endometriosis-associated infertility. Reproductive Medicine and Biology 2016; 15 (4): 217–25.
33. Uncu G, Kasapoglu I, Ozerkan K et al. Prospective assessment of the impact of endometriomas and their removal on ovarian reserve and determinants of the rate of decline in ovarian reserve. Hum Reprod 2013; 28 (8): 2140–5.
34. Nieweglowska D, Hajdyla-Banas I, Pitynski K et al. Age-related trends in anti-Mullerian hormone serum level in women with unilateral and bilateral ovarian endometriomas prior to surgery. Reprod Biol Endocrinol 2015; 13: 128.
35. Kitajima M, Dolmans MM, Donnez O et al. Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas. Fertil Steril 2014; 101: 1031–37.
36. Zulumyan TN, Khamoshina MB, Petrova VD. Еstimation of AMH level after surgery for benign non-inflammatory ovarian diseases of young women. Topical Issues in Experimental and Clinical Medicine: Сollection of papers of the Scientific Conference for Students, Post-Graduate Students and Young Scientists of Medical Faculties of Russian State Universities Including Foreign Participants: 2012 Nov 22–23, Surgut, Russia; р. 185–6.
37. Xu B, Guo N, Zhang XM et al. Oocyte quality is decreased in women with minimal or mild endometriosis. Sci Rep 2015; 5: 10779.
38. Llarena N, Flyckt R. Strategies to preserve and optimize fertility for patients with endometriosis. J Endometr Pelvic Pain Dis 2017; 9: 98–104.
39. AlKudmani B, Gat I, Buell D et al. In vitro Fertilization success rates after surgically treated endometriosis and effect of time interval between surgery and in vitro fertilization. J Min Invas Gynecol 2018; 25 (1): 99–104.
40. Da Broi MG, Navarro PA. Oxidative stress and oocyte quality: ethiopathogenic mechanisms of minimal/mild endometriosis-related infertility. Cell Tissue Res 2016; 364: 1–7.
41. Giacomini E, Sanchez AM, Sarais V et al. Characteristics of follicular fluid in ovaries with endometriomas. Eur J Obstet Gynecol Reprod Biol 2017; 209: 34–8.
42. Scutiero G, Iannone P, Bernardi G et al. Oxidative stress and endometriosis: a systematic review of the literature. Oxid Med Cell Longev 2017; 2017: 7265238.
43. Da Broi MG, de Albuquerque FO, de Andrade AZ et al. Increased concentration of 8-hydroxy-2-deoxyguanosine in follicular fluid of infertile women with endometriosis. Cell Tissue Res 2016; 366: 231–42.
44. Sanchez AM, Viganò P, Somigliana E et al. The endometriotic tissue lining the internal surface of endometrioma: hormonal, genetic, epigenetic status, and gene expression profile. Reprod Sci 2015; 22: 391–401.
45. Altun T, Jindal S, Greenseid K et al. Low follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy. J Assist Reprod Genet 2011; 28: 245–51.
46. Singh AK, Dutta M, Chattopadhyay R et al. Intrafollicular interleukin-8, interleukin-12, and adrenomedullin are the promising prognostic markers of oocyte and embryo quality in women with endometriosis.
J Assist Reprod Genet 2016; 33: 1363–72.
47. Heublein S, Vrekoussis T, Kuhn C et al. Inducers of G-protein coupled estrogen receptor (GPER) in endometriosis: Potential implications for macrophages and follicle maturation. J Reprod Immunol 2013; 97: 95–103.
48. Dumesic DA, Meldrum DR, Katz-Jaffe MG et al. Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health. Fertil Steril 2015; 103: 303–16.
49. Llarena N, Flyckt R, Falcone T. Fertility Preservation in Women With Endometriosis Reproductive Health. Clinical Medicine Insights: Reproductive Health 2019; 13: 1–8.
50. Adamian L.V., Andreeva E.N., Apolikhina I.A. et al. Female infertility: modern approaches to diagnosis and treatment. Clinical practice guidelines for patient management. Moscow, 2019 (in Russian).
51. Streuli I, Benard J, Hugon-Rodin J et al. Shedding light on the fertility preservation debate in women with endometriosis: a SWOT analysis. Eur J Obstet Gynecol Reprod Biol. 2018; 229: 172–8.
52. Elizur SE, Lebovitz O, Weintraub AY et al. Pelvic inflammatory disease in women with endometriosis is more severe than in those without. Aust N Z J Obstet Gynaecol 2014; 54 (2):162–5.
53. Zulumian T.N. Reproduktivnoe zdorov'e molodykh zhenshchin posle operativnogo lecheniia dobrokachestvennykh nevospalitel'nykh boleznei iaichnikov. Avtoref. dis. ... kand. med. nauk. Moscow, 2013 (in Russian).
54. Gasparov A.S., Gazhonova V.E., Dorokhov S.I. et al. Ovarial reserve estimation in benign ovarian tumors after different surgery approaches. Kremlevskaya meditsina. Klinicheskii vestnik. Clinical annals. 2013; 1: 100–5 (in Russian).
55. Strizhakov A.N., Davydov A.I., Ignatko I.V. et al. Effect of complex use of argon plasma surgery and fibrin cryoprecipitate on the functional state of ovaries in patients with endometrioid cysts. Voprosy ginekologii, akusherstva i perinatologii. 2016; 15 (6): 5–11 (in Russian).
56. Asgari Z, Rouholamin S, Hosseini R et al. Comparing ovarian reserve after laparoscopic excision of endometriotic cysts and hemostasis achieved either by bipolar coagulate on or suturing: a randomized clinical trial. Arch Gynecol Obstet 2016; 293: 1015–22.
57. Ahmad G, O’Flynn H, Hindocha A, Watson A. Barrier agents for adhesion prevention after gynaecological surgery. Cochrane Database Syst Rev 2015; 2: CD000475.
58. Dunselman GAJ, Vermeulen N, Becker C et al. ESHRE guideline: management of women with endometriosis. Hum Report 2014; 29 (3): 400–12.
59. Hamdan M, Dunselman G, Li TC, Cheong Y. The impact of endometrioma on IVF/ICSI outcomes: a systematic review and metaanalysis. Hum Reprod Update 2015; 21: 809–25.
60. Muzii L, Achilli C, Lecce F et al. Second surgery for recurrent endometriomas is more harmful to healthy ovarian tissue and ovarian reserve than first surgery. Fertil Steril 2015; 103: 738–43.
[Adamyan L.V., Andreeva E.N., Apolikhina I.A. et al. Endometrioz: federal'nye klinicheskie rekomendatsii po vedeniyu bol'nykh. Мoscow, 2016 (in Russian).]
2. Adamson GD, Kennedy S, Hummelshoj L. Creating solutions in endometriosis: global collaboration through the World Endometriosis Research Foundation. J Endometrios 2010; 2 (1): 3–6.
3. Gałczyński K, Jóźwik M, Lewkowicz D et al. Ovarian endometrioma – a possible finding in adolescent girls and young women: a mini-review.
J Ovar Res 2019; 12 (1): 104.
4. Benagiano G, Guo SW, Puttemans P et al. Progress in the diagnosis and management of adolescent endometriosis: an opinion. Reprod Bio Med Online 2018; 36: 102–14.
5. Macer ML, Taylor HS. Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility. Obstet Gynecol Clin N Am 2012; 39 (4): 535–49.
6. Оразов М.Р., Радзинский В.Е., Хамошина М.Б. и др. Эффективность лечения бесплодия, обусловленного рецидивирующим наружным генитальным эндометриозом. Гинекология. 2019; 21 (1): 38–43.
[Orazov M.R., Radzinskiy V.E., Khamoshina M.B. et al. Treatment efficacy of infertility due to recurrent external genital endometriosis. Gynecology. 2019; 21 (1): 38–43 (in Russian).]
7. Radzinskiy VE, Orazov MR, Ivanov II et al. Implantation failures in women with infertility associated endometriosis. Gynecological Endocrinology 2019; 35 (1): 27–30.
8. Evans MB, Decherney AH. Fertility and endometriosis. Clin Obstet Gynecol 2017; 60: 497–502.
9. Cranney R, Condous G, Reid S. An update on the diagnosis, surgical management, and fertility outcomes for women with endometrioma. Acta Obstet Gynecol Scand 2017; 96 (6): 633–43.
10. When more is not better: 10 don’ts in endometriosis management. An ETIC position statement. Hum Reprod Open 2019; 3: hoz009.
11. Donnez J, Nisolle M, Gillet N et al. Large ovarian endometriomas. Hum Reprod 1996; 11 (3): 641–46.
12. Vercellini P, Somigliana E, Vigano P et al. ‘Blood On The Tracks’ from corpora lutea to endometriomas. BJOG 2009; 116 (3): 366–71.
13. Hughesdon P. The structure of endometrial cysts of the ovary. J Obstet Gynaecol Br Em 1957; 64: 481–7.
14. Brosens IA, Puttemans PJ, Deprest J. The endoscopic localization of endometrial implants in the ovarian chocolate cyst. Fertil Steril 1994; 61: 1034–8.
15. Gogacz M, Gałczyński K, Wojtaś M et al. Fas-related apoptosis of peritoneal fluid macrophages in endometriosis patients: understanding the disease. J Immunol Res 2017; 2017: 3175394.
16. Ria R, Loverro A, Vacca A et al. Angiogenesis extent and expression of matrix metalloproteinase-2 and -9 agree with progression of ovarian endometriomas. Eur J Clin Invest 2002; 32 (3): 199–206.
17. Bulun SE, Yilmaz BD, Sison C et al. Endometriosis. Endocr Rev. 2019; 40 (4): 1048–79.
18. Rizner TL. Estrogen metabolism and action in endometriosis. Mol Cell Endocrinol 2009; 307 (1–2): 8–18.
19. Артымук Н.В., Гуляева Л.Ф., Зотова О.А. Особенности метаболизма и рецепция эстрогенов при гиперпластических процессах эндометрия и эндометриозе. Мать и дитя в Кузбассе. 2012; 1: 8–12.
[Artymuk N.V., Guljaeva L.F., Zotova O.A. Metabolism peculiaritirs and estrogenes reception in endometrial hyperplasia and endometriosis. Mat' i ditia v Kuzbasse. 2012; 1: 8–12 (in Russian).]
20. Hayashi A, Tanabe A, Kawabe S et al. Dienogest increases the progesterone receptor isoform B/A ratio in patients with ovarian endometriosis. J Ovarian Res 2012; 5 (1): 31.
21. Brosens I, Benagiano G. Clinical significance of neonatal menstruation. Eur J Obstet Gynecol Reprod Biol 2016; 196: 57–9.
22. Benagiano G, Bianchi P, Brosens I. Ovarian endometriomas in adolescents often represent active angiogenic disease requiring early diagnosis and careful management. Minerva Ginecol 2017; 69: 100–7.
23. Sanchez AM, Vigano P, Somigliana E et al. The distinguishing cellular and molecular features of the endometriotic ovarian cyst: from pathophysiology to the potential endometrioma-mediated damage to the ovary. Hum Reprod Update 2014; 20 (2): 217–30.
24. Jwabuchi T, Yoshimoto C, Shigetomi H, Kobayashi H. Oxidative stress and antioxidant defense in endometriosis and its malignant transformation. Oxid Med Cell Longev 2015; 2015: 848595.
25. Мелкозерова О.А., Башмакова Н.В., Окулова Е.О. Генетические и эпигенетические механизмы бесплодия, ассоциированного с генитальным эндометриозом. Акушерство и гинекология. 2019; 8: 26–32.
[Melkozerova O.A., Bashmakova N.V., Okulova E.O. Genetic and epigenetic mechanisms of infertility associated with genital endometriosis. Obstetrics and gynecology. 2019; 8: 26–32 (in Russian).]
26. Ghosh AK, Vaughan DE. PAI-1 in tissue fibrosis. J Cell Physiol 2012; 227 (2): 493–507.
27. Samarakoon R, Overstreet JM, Higgings PJ. TGF-beta signaling in tissue fibro sis: redox controls, target genes and therapeutic opportunities. Cell Signal 2013; 25: 264–8.
28. Rahmioglu N, Nyholt DR, Morris AP et al. Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets. Hum Reprod Update 2014; 20 (5): 702–16.
29. Qiu JJ, Liu YL, Liu MH et al. Ovarian interstitial blood flow changes assessed by transvaginal colour Doppler sonography: predicting ovarian endometrioid cyst-induced injury to ovarian interstitial vessels. Arch Gynecol Obstet 2012; 285 (2): 427–33.
30. Maneschi F, Marasa L, Incandela S et al. Ovarian cortex surrounding benign neoplasms: a histologic study. Am J Obstet Gynecol 1993; 169: 388–93.
31. Cranney R, Condous G, Reid S. An update on the diagnosis, surgical management, and fertility outcomes for women with endometrioma. Acta Obstet Gynecol Scand 2017; 96 (6): 633–43.
32. Khine YM, Taniguchi F, Harada T. Clinical management of endometriosis-associated infertility. Reproductive Medicine and Biology 2016; 15 (4): 217–25.
33. Uncu G, Kasapoglu I, Ozerkan K et al. Prospective assessment of the impact of endometriomas and their removal on ovarian reserve and determinants of the rate of decline in ovarian reserve. Hum Reprod 2013; 28 (8): 2140–5.
34. Nieweglowska D, Hajdyla-Banas I, Pitynski K et al. Age-related trends in anti-Mullerian hormone serum level in women with unilateral and bilateral ovarian endometriomas prior to surgery. Reprod Biol Endocrinol 2015; 13: 128.
35. Kitajima M, Dolmans MM, Donnez O et al. Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas. Fertil Steril 2014; 101: 1031–37.
36. Zulumyan TN, Khamoshina MB, Petrova VD. Еstimation of AMH level after surgery for benign non-inflammatory ovarian diseases of young women. Topical Issues in Experimental and Clinical Medicine: Сollection of papers of the Scientific Conference for Students, Post-Graduate Students and Young Scientists of Medical Faculties of Russian State Universities Including Foreign Participants: 2012 Nov 22–23, Surgut, Russia; р. 185–6.
37. Xu B, Guo N, Zhang XM et al. Oocyte quality is decreased in women with minimal or mild endometriosis. Sci Rep 2015; 5: 10779.
38. Llarena N, Flyckt R. Strategies to preserve and optimize fertility for patients with endometriosis. J Endometr Pelvic Pain Dis 2017; 9: 98–104.
39. AlKudmani B, Gat I, Buell D et al. In vitro Fertilization success rates after surgically treated endometriosis and effect of time interval between surgery and in vitro fertilization. J Min Invas Gynecol 2018; 25 (1): 99–104.
40. Da Broi MG, Navarro PA. Oxidative stress and oocyte quality: ethiopathogenic mechanisms of minimal/mild endometriosis-related infertility. Cell Tissue Res 2016; 364: 1–7.
41. Giacomini E, Sanchez AM, Sarais V et al. Characteristics of follicular fluid in ovaries with endometriomas. Eur J Obstet Gynecol Reprod Biol 2017; 209: 34–8.
42. Scutiero G, Iannone P, Bernardi G et al. Oxidative stress and endometriosis: a systematic review of the literature. Oxid Med Cell Longev 2017; 2017: 7265238.
43. Da Broi MG, de Albuquerque FO, de Andrade AZ et al. Increased concentration of 8-hydroxy-2-deoxyguanosine in follicular fluid of infertile women with endometriosis. Cell Tissue Res 2016; 366: 231–42.
44. Sanchez AM, Viganò P, Somigliana E et al. The endometriotic tissue lining the internal surface of endometrioma: hormonal, genetic, epigenetic status, and gene expression profile. Reprod Sci 2015; 22: 391–401.
45. Altun T, Jindal S, Greenseid K et al. Low follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy. J Assist Reprod Genet 2011; 28: 245–51.
46. Singh AK, Dutta M, Chattopadhyay R et al. Intrafollicular interleukin-8, interleukin-12, and adrenomedullin are the promising prognostic markers of oocyte and embryo quality in women with endometriosis.
J Assist Reprod Genet 2016; 33: 1363–72.
47. Heublein S, Vrekoussis T, Kuhn C et al. Inducers of G-protein coupled estrogen receptor (GPER) in endometriosis: Potential implications for macrophages and follicle maturation. J Reprod Immunol 2013; 97: 95–103.
48. Dumesic DA, Meldrum DR, Katz-Jaffe MG et al. Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health. Fertil Steril 2015; 103: 303–16.
49. Llarena N, Flyckt R, Falcone T. Fertility Preservation in Women With Endometriosis Reproductive Health. Clinical Medicine Insights: Reproductive Health 2019; 13: 1–8.
50. Адамян Л.В., Андреева Е.Н., Аполихина И.А. и др. Женское бесплодие: современные подходы к диагностике и лечению. Клинические рекомендации по ведению больных. М., 2019.
[Adamian L.V., Andreeva E.N., Apolikhina I.A. et al. Female infertility: modern approaches to diagnosis and treatment. Clinical practice guidelines for patient management. Moscow, 2019 (in Russian).]
51. Streuli I, Benard J, Hugon-Rodin J et al. Shedding light on the fertility preservation debate in women with endometriosis: a SWOT analysis. Eur J Obstet Gynecol Reprod Biol. 2018; 229: 172–8.
52. Elizur SE, Lebovitz O, Weintraub AY et al. Pelvic inflammatory disease in women with endometriosis is more severe than in those without. Aust N Z J Obstet Gynaecol 2014; 54 (2):162–5.
53. Зулумян Т.Н. Репродуктивное здоровье молодых женщин после оперативного лечения доброкачественных невоспалительных болезней яичников. Автореф. дис. ... канд. мед. наук. М., 2013.
[Zulumian T.N. Reproduktivnoe zdorov'e molodykh zhenshchin posle operativnogo lecheniia dobrokachestvennykh nevospalitel'nykh boleznei iaichnikov. Avtoref. dis. ... kand. med. nauk. Moscow, 2013 (in Russian).]
54. Гаспаров А.С., Гажонова В.Е., Дорохов С.И. и др. Оценка овариального резерва яичников с доброкачественными опухолями после разных видов хирургического лечения. Кремлевская медицина. Клинический вестник. 2013; 1: 100–5.
[Gasparov A.S., Gazhonova V.E., Dorokhov S.I. et al. Ovarial reserve estimation in benign ovarian tumors after different surgery approaches. Kremlevskaya meditsina. Klinicheskii vestnik. Clinical annals. 2013; 1: 100–5 (in Russian).]
55. Стрижаков А.Н., Давыдов А.И., Игнатко И.В. и др. Оценка комплексного применения аргоноплазменной хирургии и фибринового криопреципитата на функциональное состояние яичников у пациенток с эндометриоидными кистами. Вопросы гинекологии, акушерства и перинатологии. 2016;15 (6): 5–11.
[Strizhakov A.N., Davydov A.I., Ignatko I.V. et al. Effect of complex use of argon plasma surgery and fibrin cryoprecipitate on the functional state of ovaries in patients with endometrioid cysts. Voprosy ginekologii, akusherstva i perinatologii. 2016; 15 (6): 5–11 (in Russian).]
56. Asgari Z, Rouholamin S, Hosseini R et al. Comparing ovarian reserve after laparoscopic excision of endometriotic cysts and hemostasis achieved either by bipolar coagulate on or suturing: a randomized clinical trial. Arch Gynecol Obstet 2016; 293: 1015–22.
57. Ahmad G, O’Flynn H, Hindocha A, Watson A. Barrier agents for adhesion prevention after gynaecological surgery. Cochrane Database Syst Rev 2015; 2: CD000475.
58. Dunselman GAJ, Vermeulen N, Becker C et al. ESHRE guideline: management of women with endometriosis. Hum Report 2014; 29 (3): 400–12.
59. Hamdan M, Dunselman G, Li TC, Cheong Y. The impact of endometrioma on IVF/ICSI outcomes: a systematic review and metaanalysis. Hum Reprod Update 2015; 21: 809–25.
60. Muzii L, Achilli C, Lecce F et al. Second surgery for recurrent endometriomas is more harmful to healthy ovarian tissue and ovarian reserve than first surgery. Fertil Steril 2015; 103: 738–43.
________________________________________________
2. Adamson GD, Kennedy S, Hummelshoj L. Creating solutions in endometriosis: global collaboration through the World Endometriosis Research Foundation. J Endometrios 2010; 2 (1): 3–6.
3. Gałczyński K, Jóźwik M, Lewkowicz D et al. Ovarian endometrioma – a possible finding in adolescent girls and young women: a mini-review.
J Ovar Res 2019; 12 (1): 104.
4. Benagiano G, Guo SW, Puttemans P et al. Progress in the diagnosis and management of adolescent endometriosis: an opinion. Reprod Bio Med Online 2018; 36: 102–14.
5. Macer ML, Taylor HS. Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility. Obstet Gynecol Clin N Am 2012; 39 (4): 535–49.
6. Orazov M.R., Radzinskiy V.E., Khamoshina M.B. et al. Treatment efficacy of infertility due to recurrent external genital endometriosis. Gynecology. 2019; 21 (1): 38–43 (in Russian).
7. Radzinskiy VE, Orazov MR, Ivanov II et al. Implantation failures in women with infertility associated endometriosis. Gynecological Endocrinology 2019; 35 (1): 27–30.
8. Evans MB, Decherney AH. Fertility and endometriosis. Clin Obstet Gynecol 2017; 60: 497–502.
9. Cranney R, Condous G, Reid S. An update on the diagnosis, surgical management, and fertility outcomes for women with endometrioma. Acta Obstet Gynecol Scand 2017; 96 (6): 633–43.
10. When more is not better: 10 don’ts in endometriosis management. An ETIC position statement. Hum Reprod Open 2019; 3: hoz009.
11. Donnez J, Nisolle M, Gillet N et al. Large ovarian endometriomas. Hum Reprod 1996; 11 (3): 641–46.
12. Vercellini P, Somigliana E, Vigano P et al. ‘Blood On The Tracks’ from corpora lutea to endometriomas. BJOG 2009; 116 (3): 366–71.
13. Hughesdon P. The structure of endometrial cysts of the ovary. J Obstet Gynaecol Br Em 1957; 64: 481–7.
14. Brosens IA, Puttemans PJ, Deprest J. The endoscopic localization of endometrial implants in the ovarian chocolate cyst. Fertil Steril 1994; 61: 1034–8.
15. Gogacz M, Gałczyński K, Wojtaś M et al. Fas-related apoptosis of peritoneal fluid macrophages in endometriosis patients: understanding the disease. J Immunol Res 2017; 2017: 3175394.
16. Ria R, Loverro A, Vacca A et al. Angiogenesis extent and expression of matrix metalloproteinase-2 and -9 agree with progression of ovarian endometriomas. Eur J Clin Invest 2002; 32 (3): 199–206.
17. Bulun SE, Yilmaz BD, Sison C et al. Endometriosis. Endocr Rev. 2019; 40 (4): 1048–79.
18. Rizner TL. Estrogen metabolism and action in endometriosis. Mol Cell Endocrinol 2009; 307 (1–2): 8–18.
19. Artymuk N.V., Guljaeva L.F., Zotova O.A. Metabolism peculiaritirs and estrogenes reception in endometrial hyperplasia and endometriosis. Mat' i ditia v Kuzbasse. 2012; 1: 8–12 (in Russian).
20. Hayashi A, Tanabe A, Kawabe S et al. Dienogest increases the progesterone receptor isoform B/A ratio in patients with ovarian endometriosis. J Ovarian Res 2012; 5 (1): 31.
21. Brosens I, Benagiano G. Clinical significance of neonatal menstruation. Eur J Obstet Gynecol Reprod Biol 2016; 196: 57–9.
22. Benagiano G, Bianchi P, Brosens I. Ovarian endometriomas in adolescents often represent active angiogenic disease requiring early diagnosis and careful management. Minerva Ginecol 2017; 69: 100–7.
23. Sanchez AM, Vigano P, Somigliana E et al. The distinguishing cellular and molecular features of the endometriotic ovarian cyst: from pathophysiology to the potential endometrioma-mediated damage to the ovary. Hum Reprod Update 2014; 20 (2): 217–30.
24. Jwabuchi T, Yoshimoto C, Shigetomi H, Kobayashi H. Oxidative stress and antioxidant defense in endometriosis and its malignant transformation. Oxid Med Cell Longev 2015; 2015: 848595.
25. Melkozerova O.A., Bashmakova N.V., Okulova E.O. Genetic and epigenetic mechanisms of infertility associated with genital endometriosis. Obstetrics and gynecology. 2019; 8: 26–32 (in Russian).
26. Ghosh AK, Vaughan DE. PAI-1 in tissue fibrosis. J Cell Physiol 2012; 227 (2): 493–507.
27. Samarakoon R, Overstreet JM, Higgings PJ. TGF-beta signaling in tissue fibro sis: redox controls, target genes and therapeutic opportunities. Cell Signal 2013; 25: 264–8.
28. Rahmioglu N, Nyholt DR, Morris AP et al. Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets. Hum Reprod Update 2014; 20 (5): 702–16.
29. Qiu JJ, Liu YL, Liu MH et al. Ovarian interstitial blood flow changes assessed by transvaginal colour Doppler sonography: predicting ovarian endometrioid cyst-induced injury to ovarian interstitial vessels. Arch Gynecol Obstet 2012; 285 (2): 427–33.
30. Maneschi F, Marasa L, Incandela S et al. Ovarian cortex surrounding benign neoplasms: a histologic study. Am J Obstet Gynecol 1993; 169: 388–93.
31. Cranney R, Condous G, Reid S. An update on the diagnosis, surgical management, and fertility outcomes for women with endometrioma. Acta Obstet Gynecol Scand 2017; 96 (6): 633–43.
32. Khine YM, Taniguchi F, Harada T. Clinical management of endometriosis-associated infertility. Reproductive Medicine and Biology 2016; 15 (4): 217–25.
33. Uncu G, Kasapoglu I, Ozerkan K et al. Prospective assessment of the impact of endometriomas and their removal on ovarian reserve and determinants of the rate of decline in ovarian reserve. Hum Reprod 2013; 28 (8): 2140–5.
34. Nieweglowska D, Hajdyla-Banas I, Pitynski K et al. Age-related trends in anti-Mullerian hormone serum level in women with unilateral and bilateral ovarian endometriomas prior to surgery. Reprod Biol Endocrinol 2015; 13: 128.
35. Kitajima M, Dolmans MM, Donnez O et al. Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas. Fertil Steril 2014; 101: 1031–37.
36. Zulumyan TN, Khamoshina MB, Petrova VD. Еstimation of AMH level after surgery for benign non-inflammatory ovarian diseases of young women. Topical Issues in Experimental and Clinical Medicine: Сollection of papers of the Scientific Conference for Students, Post-Graduate Students and Young Scientists of Medical Faculties of Russian State Universities Including Foreign Participants: 2012 Nov 22–23, Surgut, Russia; р. 185–6.
37. Xu B, Guo N, Zhang XM et al. Oocyte quality is decreased in women with minimal or mild endometriosis. Sci Rep 2015; 5: 10779.
38. Llarena N, Flyckt R. Strategies to preserve and optimize fertility for patients with endometriosis. J Endometr Pelvic Pain Dis 2017; 9: 98–104.
39. AlKudmani B, Gat I, Buell D et al. In vitro Fertilization success rates after surgically treated endometriosis and effect of time interval between surgery and in vitro fertilization. J Min Invas Gynecol 2018; 25 (1): 99–104.
40. Da Broi MG, Navarro PA. Oxidative stress and oocyte quality: ethiopathogenic mechanisms of minimal/mild endometriosis-related infertility. Cell Tissue Res 2016; 364: 1–7.
41. Giacomini E, Sanchez AM, Sarais V et al. Characteristics of follicular fluid in ovaries with endometriomas. Eur J Obstet Gynecol Reprod Biol 2017; 209: 34–8.
42. Scutiero G, Iannone P, Bernardi G et al. Oxidative stress and endometriosis: a systematic review of the literature. Oxid Med Cell Longev 2017; 2017: 7265238.
43. Da Broi MG, de Albuquerque FO, de Andrade AZ et al. Increased concentration of 8-hydroxy-2-deoxyguanosine in follicular fluid of infertile women with endometriosis. Cell Tissue Res 2016; 366: 231–42.
44. Sanchez AM, Viganò P, Somigliana E et al. The endometriotic tissue lining the internal surface of endometrioma: hormonal, genetic, epigenetic status, and gene expression profile. Reprod Sci 2015; 22: 391–401.
45. Altun T, Jindal S, Greenseid K et al. Low follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy. J Assist Reprod Genet 2011; 28: 245–51.
46. Singh AK, Dutta M, Chattopadhyay R et al. Intrafollicular interleukin-8, interleukin-12, and adrenomedullin are the promising prognostic markers of oocyte and embryo quality in women with endometriosis.
J Assist Reprod Genet 2016; 33: 1363–72.
47. Heublein S, Vrekoussis T, Kuhn C et al. Inducers of G-protein coupled estrogen receptor (GPER) in endometriosis: Potential implications for macrophages and follicle maturation. J Reprod Immunol 2013; 97: 95–103.
48. Dumesic DA, Meldrum DR, Katz-Jaffe MG et al. Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health. Fertil Steril 2015; 103: 303–16.
49. Llarena N, Flyckt R, Falcone T. Fertility Preservation in Women With Endometriosis Reproductive Health. Clinical Medicine Insights: Reproductive Health 2019; 13: 1–8.
50. Adamian L.V., Andreeva E.N., Apolikhina I.A. et al. Female infertility: modern approaches to diagnosis and treatment. Clinical practice guidelines for patient management. Moscow, 2019 (in Russian).
51. Streuli I, Benard J, Hugon-Rodin J et al. Shedding light on the fertility preservation debate in women with endometriosis: a SWOT analysis. Eur J Obstet Gynecol Reprod Biol. 2018; 229: 172–8.
52. Elizur SE, Lebovitz O, Weintraub AY et al. Pelvic inflammatory disease in women with endometriosis is more severe than in those without. Aust N Z J Obstet Gynaecol 2014; 54 (2):162–5.
53. Zulumian T.N. Reproduktivnoe zdorov'e molodykh zhenshchin posle operativnogo lecheniia dobrokachestvennykh nevospalitel'nykh boleznei iaichnikov. Avtoref. dis. ... kand. med. nauk. Moscow, 2013 (in Russian).
54. Gasparov A.S., Gazhonova V.E., Dorokhov S.I. et al. Ovarial reserve estimation in benign ovarian tumors after different surgery approaches. Kremlevskaya meditsina. Klinicheskii vestnik. Clinical annals. 2013; 1: 100–5 (in Russian).
55. Strizhakov A.N., Davydov A.I., Ignatko I.V. et al. Effect of complex use of argon plasma surgery and fibrin cryoprecipitate on the functional state of ovaries in patients with endometrioid cysts. Voprosy ginekologii, akusherstva i perinatologii. 2016; 15 (6): 5–11 (in Russian).
56. Asgari Z, Rouholamin S, Hosseini R et al. Comparing ovarian reserve after laparoscopic excision of endometriotic cysts and hemostasis achieved either by bipolar coagulate on or suturing: a randomized clinical trial. Arch Gynecol Obstet 2016; 293: 1015–22.
57. Ahmad G, O’Flynn H, Hindocha A, Watson A. Barrier agents for adhesion prevention after gynaecological surgery. Cochrane Database Syst Rev 2015; 2: CD000475.
58. Dunselman GAJ, Vermeulen N, Becker C et al. ESHRE guideline: management of women with endometriosis. Hum Report 2014; 29 (3): 400–12.
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Авторы
М.Р. Оразов1, М.Б. Хамошина1, М.З. Абитова*1, Л.М. Михалева2, С.В. Волкова1, Д.Г. Арютин1,3, В.Б. Шустова4
1 ФГАОУ ВО «Российский университет дружбы народов», Москва, Россия;
2 ГБНУ «Научно-исследовательский институт морфологии человека», Москва, Россия;
3 ГБУЗ «Государственная клиническая больница №29 им. Н.Э. Баумана», Москва, Россия;
4 ООО «МедИнСервис» – Центр репродукции и генетики «Nova Clinic» («МедИнСервис»), Москва, Россия
*abitovamarianna@yandex.ru
1 Peoples' Friendship University of Russia, Moscow, Russia;
2 Research Institute of Human Morphology, Moscow, Russia;
3 Bauman State Clinical Hospital №29, Moscow, Russia;
4 MedInService – Center for Reproduction and Genetics “Nova Clinic” (“MedInService”), Moscow, Russia
*abitovamarianna@yandex.ru
1 ФГАОУ ВО «Российский университет дружбы народов», Москва, Россия;
2 ГБНУ «Научно-исследовательский институт морфологии человека», Москва, Россия;
3 ГБУЗ «Государственная клиническая больница №29 им. Н.Э. Баумана», Москва, Россия;
4 ООО «МедИнСервис» – Центр репродукции и генетики «Nova Clinic» («МедИнСервис»), Москва, Россия
*abitovamarianna@yandex.ru
________________________________________________
1 Peoples' Friendship University of Russia, Moscow, Russia;
2 Research Institute of Human Morphology, Moscow, Russia;
3 Bauman State Clinical Hospital №29, Moscow, Russia;
4 MedInService – Center for Reproduction and Genetics “Nova Clinic” (“MedInService”), Moscow, Russia
*abitovamarianna@yandex.ru
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