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Течение и исходы новой коронавирусной инфекции COVID-19 у беременных: эпидемиологическое исследование в Сибири и на Дальнем Востоке
Течение и исходы новой коронавирусной инфекции COVID-19 у беременных: эпидемиологическое исследование в Сибири и на Дальнем Востоке
Белокриницкая Т.Е., Артымук Н.В., Филиппов О.С., Фролова Н.И. Течение и исходы новой коронавирусной инфекции COVID-19 у беременных: эпидемиологическое исследование в Сибири и на Дальнем Востоке. Гинекология. 2021; 23 (1): 43–47. DOI: 10.26442/20795696.2021.1.200639
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Аннотация
Цель. Дать оценку заболеваемости, клинического течения, исходов новой коронавирусной инфекции (НКИ) COVID-19 для матери и ребенка в популяции беременных Дальневосточного (ДФО) и Сибирского федеральных округов (СФО).
Материалы и методы. Дизайн – популяционное эпидемиологическое проспективное исследование. Проведен анализ оперативной информации о заболеваемости, особенностях течения НКИ COVID-19 у беременных, рожениц и родильниц, материнских и перинатальных исходах, предоставленной главными акушерами-гинекологами ДФО и СФО за период с 11 марта по 25 декабря 2020 г. Математический анализ включал методы описательной статистики, анализ таблиц сопряженности, где оценивали значение χ2, достигнутый уровень значимости (р).
Результаты. За период эпидемии COVID-19 в 2020 г. в ДФО и СФО вирус SARS-CoV-2 идентифицирован у 8485 беременных, рожениц и родильниц (5,9% от состоявших на учете беременных; 1,71% от всего заболевшего населения). Показатель заболеваемости беременных в 3,0 раза выше, чем в популяции в целом: 5933,2 vs 1960,8 на 100 тыс. человек (р<0,001). В 27,4% (2329) случаев SARS-CoV-2-инфекция протекала бессимптомно, в 53,0% (4500) – в легкой форме, в 16,6% (1407) – среднетяжелой, в 2,5% (210) имела тяжелое и в 0,5% (39) – крайне тяжелое течение. В реанимационно-анестезиологических отделениях прошли лечение 3,57% заболевших беременных и 2,24% в общей популяции (р<0,001). Инвазивная искусственная вентиляция легких беременным проводилась реже, чем среди населения: 0,48% vs 1,05% (р<0,001). Завершили беременность 27,97% (2373) женщин с подтвержденной НКИ COVID-19. У 81,7% матерей роды произошли в срок, у 18,3% – преждевременно. Родоразрешены операцией кесарева сечения 42,0% женщин, оперативные влагалищные роды (вакуум-экстракция плода, акушерские щипцы) зарегистрированы в 0,2% случаев. Погибли 12 (0,14%) матерей. Показатель материнской смертности составил 505,69 на 100 тыс. живорожденных (0,51% от числа родивших пациенток с COVID-19). Показатели смертности и удельного веса умерших в общей популяции статистически значимо выше: 1948,93 на 100 тыс. заболевшего населения и 1,95% (р<0,001). Зарегистрировано 37 (1,56%) случаев перинатальных потерь: 31 (1,30%) – мертворождений, 6 (0,26%) – ранней неонатальной смертности. Вирус SARS-CoV-2 обнаружен у 148 (6,2%) новорожденных при соблюдении противоэпидемических мероприятий и разделении матери и ребенка сразу после родов.
Заключение. Частота идентификации вируса SARS-CoV-2 у беременных, рожениц и родильниц Сибири и Дальнего Востока в 3,0 раза выше, чем в общей популяции, при этом инфекционный процесс характеризуется более легким течением (меньше потребность в инвазивной искусственной вентиляции легких, ниже показатель смертности). У матерей с COVID-19 преждевременные роды регистрировали чаще в 3,0 раза, родоразрешение операцией кесарева сечения – чаще в
1,4 раза по сравнению со среднепопуляционными показателями. Выявление РНК вируса SARS-CoV-2 у 6,2% новорожденных позволяет предполагать возможность вертикальной трансмиссии инфекции.
Ключевые слова: COVID-19, беременность, заболеваемость, роды, материнская смертность, перинатальная смертность
Materials and methods. The study design: a population-based epidemiological prospective study. We analyzed operative information on NKI COVID-19 incidence and features of clinical course in pregnant women, women in labor and parturient women as well as maternal and perinatal outcomes for March 11 to December 25, 2020 which were provided by the FEFD and SFD chief obstetricians-gynecologists. Mathematical analysis included methods of descriptive statistics, analysis of contingency table, where the value of χ2, the achieved level of significance (p) was estimated.
Results. In the FEFD and SFD, over the COVID-19 2020 epidemic, the SARS-CoV-2 virus was revealed in 8485 pregnant women, women in labor and postpartum women (5.9% of pregnant women subjected to regular medical check-up; 1.71% of the sick entire population). The incidence rate in pregnant women was 3.0 times higher than in the entire population: 5933,2 vs 1960,8 per 100 thousand (p<0.001). Among SARS-CoV-2 infected patients, 27.4% (2324) were asymptomatic, 52.7% (4471) have mild, 16.6% (1388) – moderate, 2.5% (210) – severe 0,5% (39) – extremely severe clinical course. In the intensive care and anesthesiology departments, 3.57% of pregnant women and 2.24% of the entire population (p<0.001) have been treated. Rate of using invasive artificial lung ventilation in pregnant women was lower than in the population: 0.48% vs 1.05% (p<0.001). 27.97% (2373) of women with confirmed NKI COVID-19 completed pregnancy. 81,7% of mothers delivered on time, 18.3% – prematurely. Cesarean delivery was performed in 42,0% of women, operative vaginal delivery (vacuum extraction, obstetric forceps) was registered in 0.2% of cases. 12 (0.14%) mothers died. The maternal mortality rate was 505.69 per 100 thousand live births (0.51% of patients with COVID-19 who gave birth). Mortality rates and the proportion of deaths in the entire population were statistically significantly higher: 1948.93 per 100 thousand sick population and 1.95% (p<0.001), respectively. 37 (1.56%) cases of perinatal losses were registered, of which 31 (1.30%) – stillbirths, 6 (0.26%) – early neonatal mortality. The SARS-CoV-2 virus was revealed in 148 (6.2%) newborns with the observance of anti-epidemic measures and separation of the mother and child immediately after delivery.
Conclusion. The rate of revealing SARS-CoV-2 virus in pregnant women, women in labor and parturient women in Siberia and the Far East was 3.0 times higher than in the entire population, while clinical course of infectious process was less severe (less need for invasive mechanical ventilation, lower mortality rate). In mothers with COVID-19, preterm birth rate was 3.0 times higher, caesarean delivery rate –1.4 times higher compared with the average population indicators. Reveling SARS-CoV-2 virus RNA in 6.2% of newborns suggests the possibility of vertical transmission of the infection.
Keywords: COVID-19, pregnancy, morbidity, childbirth, maternal mortality, perinatal mortality
Материалы и методы. Дизайн – популяционное эпидемиологическое проспективное исследование. Проведен анализ оперативной информации о заболеваемости, особенностях течения НКИ COVID-19 у беременных, рожениц и родильниц, материнских и перинатальных исходах, предоставленной главными акушерами-гинекологами ДФО и СФО за период с 11 марта по 25 декабря 2020 г. Математический анализ включал методы описательной статистики, анализ таблиц сопряженности, где оценивали значение χ2, достигнутый уровень значимости (р).
Результаты. За период эпидемии COVID-19 в 2020 г. в ДФО и СФО вирус SARS-CoV-2 идентифицирован у 8485 беременных, рожениц и родильниц (5,9% от состоявших на учете беременных; 1,71% от всего заболевшего населения). Показатель заболеваемости беременных в 3,0 раза выше, чем в популяции в целом: 5933,2 vs 1960,8 на 100 тыс. человек (р<0,001). В 27,4% (2329) случаев SARS-CoV-2-инфекция протекала бессимптомно, в 53,0% (4500) – в легкой форме, в 16,6% (1407) – среднетяжелой, в 2,5% (210) имела тяжелое и в 0,5% (39) – крайне тяжелое течение. В реанимационно-анестезиологических отделениях прошли лечение 3,57% заболевших беременных и 2,24% в общей популяции (р<0,001). Инвазивная искусственная вентиляция легких беременным проводилась реже, чем среди населения: 0,48% vs 1,05% (р<0,001). Завершили беременность 27,97% (2373) женщин с подтвержденной НКИ COVID-19. У 81,7% матерей роды произошли в срок, у 18,3% – преждевременно. Родоразрешены операцией кесарева сечения 42,0% женщин, оперативные влагалищные роды (вакуум-экстракция плода, акушерские щипцы) зарегистрированы в 0,2% случаев. Погибли 12 (0,14%) матерей. Показатель материнской смертности составил 505,69 на 100 тыс. живорожденных (0,51% от числа родивших пациенток с COVID-19). Показатели смертности и удельного веса умерших в общей популяции статистически значимо выше: 1948,93 на 100 тыс. заболевшего населения и 1,95% (р<0,001). Зарегистрировано 37 (1,56%) случаев перинатальных потерь: 31 (1,30%) – мертворождений, 6 (0,26%) – ранней неонатальной смертности. Вирус SARS-CoV-2 обнаружен у 148 (6,2%) новорожденных при соблюдении противоэпидемических мероприятий и разделении матери и ребенка сразу после родов.
Заключение. Частота идентификации вируса SARS-CoV-2 у беременных, рожениц и родильниц Сибири и Дальнего Востока в 3,0 раза выше, чем в общей популяции, при этом инфекционный процесс характеризуется более легким течением (меньше потребность в инвазивной искусственной вентиляции легких, ниже показатель смертности). У матерей с COVID-19 преждевременные роды регистрировали чаще в 3,0 раза, родоразрешение операцией кесарева сечения – чаще в
1,4 раза по сравнению со среднепопуляционными показателями. Выявление РНК вируса SARS-CoV-2 у 6,2% новорожденных позволяет предполагать возможность вертикальной трансмиссии инфекции.
Ключевые слова: COVID-19, беременность, заболеваемость, роды, материнская смертность, перинатальная смертность
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Materials and methods. The study design: a population-based epidemiological prospective study. We analyzed operative information on NKI COVID-19 incidence and features of clinical course in pregnant women, women in labor and parturient women as well as maternal and perinatal outcomes for March 11 to December 25, 2020 which were provided by the FEFD and SFD chief obstetricians-gynecologists. Mathematical analysis included methods of descriptive statistics, analysis of contingency table, where the value of χ2, the achieved level of significance (p) was estimated.
Results. In the FEFD and SFD, over the COVID-19 2020 epidemic, the SARS-CoV-2 virus was revealed in 8485 pregnant women, women in labor and postpartum women (5.9% of pregnant women subjected to regular medical check-up; 1.71% of the sick entire population). The incidence rate in pregnant women was 3.0 times higher than in the entire population: 5933,2 vs 1960,8 per 100 thousand (p<0.001). Among SARS-CoV-2 infected patients, 27.4% (2324) were asymptomatic, 52.7% (4471) have mild, 16.6% (1388) – moderate, 2.5% (210) – severe 0,5% (39) – extremely severe clinical course. In the intensive care and anesthesiology departments, 3.57% of pregnant women and 2.24% of the entire population (p<0.001) have been treated. Rate of using invasive artificial lung ventilation in pregnant women was lower than in the population: 0.48% vs 1.05% (p<0.001). 27.97% (2373) of women with confirmed NKI COVID-19 completed pregnancy. 81,7% of mothers delivered on time, 18.3% – prematurely. Cesarean delivery was performed in 42,0% of women, operative vaginal delivery (vacuum extraction, obstetric forceps) was registered in 0.2% of cases. 12 (0.14%) mothers died. The maternal mortality rate was 505.69 per 100 thousand live births (0.51% of patients with COVID-19 who gave birth). Mortality rates and the proportion of deaths in the entire population were statistically significantly higher: 1948.93 per 100 thousand sick population and 1.95% (p<0.001), respectively. 37 (1.56%) cases of perinatal losses were registered, of which 31 (1.30%) – stillbirths, 6 (0.26%) – early neonatal mortality. The SARS-CoV-2 virus was revealed in 148 (6.2%) newborns with the observance of anti-epidemic measures and separation of the mother and child immediately after delivery.
Conclusion. The rate of revealing SARS-CoV-2 virus in pregnant women, women in labor and parturient women in Siberia and the Far East was 3.0 times higher than in the entire population, while clinical course of infectious process was less severe (less need for invasive mechanical ventilation, lower mortality rate). In mothers with COVID-19, preterm birth rate was 3.0 times higher, caesarean delivery rate –1.4 times higher compared with the average population indicators. Reveling SARS-CoV-2 virus RNA in 6.2% of newborns suggests the possibility of vertical transmission of the infection.
Keywords: COVID-19, pregnancy, morbidity, childbirth, maternal mortality, perinatal mortality
Полный текст
Список литературы
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13. Magee LA, Khalil A, von Dadelszen P. Covid-19: UK Obstetric Surveillance System (UKOSS) study in context. BMJ 2020; 370: m2915. DOI: 10.1136/bmj.m2915
14. Han Y, Ma H, Suo M, et al. Clinical manifestation, outcomes in pregnant women with COVID-19 and the possibility of vertical transmission: a systematic review of the current data. J Perinat Med 2020; 48 (9): 912–24. DOI: 10.1515/jpm-2020-0431
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16. Figueiro-Filho EA, Yudin M, Farine D. COVID-19 during pregnancy: an overview of maternal characteristics, clinical symptoms, maternal and neonatal outcomes of 10,996 cases described in 15 countries. J Perinat Med 2020; 48 (9): 900–11. DOI: 10.1515/jpm-2020-0364;
PMID: 33001856
17. Jafari M, Pormohammad A, Sheikh Neshin SA, et al. Clinical characteristics and outcomes of pregnant women with COVID-19 and comparison with control patients: A systematic review and meta-analysis. Rev Med Virol 2021: e2208. DOI: 10.1002/rmv.2208; PMID: 33387448
18. Diriba K, Awulachew E, Getu E. The effect of coronavirus infection (SARS-CoV-2, MERS-CoV, and SARS-CoV) during pregnancy and the possibility of vertical maternal-fetal transmission: a systematic review and meta-analysis. Eur J Med Res 2020; 25 (1): 39. DOI: 10.1186/s40001-020-00439-w; PMID: 32887660; PMCID: PMC7471638
19. Dubey P, Reddy SY, Manuel S, Dwivedi AK. Maternal and neonatal characteristics and outcomes among COVID-19 infected women: An updated systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol 2020; 252: 490–501. DOI: 10.1016/j.ejogrb.2020.07.034; PMID: 32795828
20. CDC Interim Guidance for General Population Disaster Shelters During the COVID-19 Pandemic. Aviable at: https://www.cdc.gov/coronavirus/2019-ncov/downloads/Guidance-for-Gen-Pop-Disaster-Shelters-COVID19.p.... Accessed: 01.09.2020.
21. Di Mascio D, Sen C, Saccone G, et al. Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19. J Perinat Med 2020; 48 (9): 950–8. DOI: 10.1515/jpm-2020-0355; PMID: 32975205
2. Белокриницкая Т.Е., Шаповалов К.Г. Грипп и беременность. М.: ГЭОТАР-Медиа, 2015 [Belokrinitskaya T.E., Shapovalov K.G. Influenza and Pregnancy. Moscow: GEOTAR-Media, 2015 (in Russian)].
3. Silasi M, Cardenas I, Kwon JY, et al. Viral infections during pregnancy. Am J Reprod Immunol 2015; 73 (3): 199–213. DOI: 10.1111/aji.12355; PMID: 25582523
4. Dashraath P, Wong JLJ, Lim MXK, et al. Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy. Am J Obstet Gynecol 2020; 222 (6): 521–31.
5. Организация оказания медицинской помощи беременным, роженицам, родильницам и новорожденным при новой коронавирусной инфекции COVID-19. Методические рекомендации. Минздрав России. Версия 2. 27.05.2020. Режим доступа: https://static-3.rosminzdrav.ru/system/attachments/attaches/000/050/533/original/28052020_Preg_COVID.... Ссылка активна на 19.02.2021 [Organization of medical care for pregnant women, women in labor, women in labor and newborns with a new coronavirus infection COVID-19. Methodological recommendations. Ministry of Health of Russia. Version 2. 27.05.2020. Aviable at: https://static-3.rosminzdrav.ru/system/attachments/attaches/000/050/533/original/28052020_Preg_COVID.... Accessed: 19.02.2021 (in Russian)].
6. Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19). Временные методические рекомендации. Минздрав России. Версия 9. 26.10.2020. Режим доступа: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/052/550/original/МР_COVID-19_%28v9%.... Ссылка активна на 11.01.2021 [Prevention, diagnosis and treatment of new coronavirus infection (COVID-19). The provisional guidelines. Ministry of Health of Russia. Version 9. 26.10.2020. Aviable at: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/052/550/original/МР_COVID-19_%28v9%.... Accessed: 11.01.2021 (in Russian)].
7. Филиппов О.С., Гусева Е.В. Основные показатели деятельности акушерско-гинекологической службы в Российской Федерации в 2019 г. М., 2020 [Filippov O.S., Guseva E.V. Key performance indicators of the obstetric and gynecological service in the Russian Federation in 2019. Moscow, 2020 (in Russian)].
8. Белокриницкая Т.Е., Артымук Н.В., Филиппов О.С., Шифман Е.М. Динамика эпидемического процесса и течение новой коронавирусной инфекции COVID-19 у беременных Дальневосточного и Сибирского федеральных округов. Гинекология. 2020; 22 (5): 6–11 [Belokrinitskaya T.E., Artymuk N.V., Filippov O.S., Shifman E.M. Dynamics of the epidemic process and the course of the COVID-19 in pregnant women of the Far Eastern and Siberian Federal Districts. Gynecology. 2020; 22 (5): 6–11 (in Russian)].
9. Zambrano LD, Ellington S, Strid P, et al. Update: Characteristics of Symptomatic Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status – United States, January 22 – October 3, 2020. MMWR Morb Mortal Wkly Rep 2020; 69 (44): 1641–7. DOI: 10.15585/mmwr.mm6944e3; PMID: 33151921
10. Aviable at: https://www.acog.org/clinical/clinical-guidance/practice-advisory/articles/2020/03/novel-coronavirus... Accessed: 19.02.2021
11. Coronavirus (COVID-19) Infection in Pregnancy. Version 12: RCOG. 14.10.2020.
12. Knight M, Bunch K, Vousden N, et al. Characteristics and outcomes of pregnant women admitted to hospital with confirmed infection in UK: national population based cohort study. BMJ 2020; 369: m2107. DOI: 10.1136/bmj.m2107
13. Magee LA, Khalil A, von Dadelszen P. Covid-19: UK Obstetric Surveillance System (UKOSS) study in context. BMJ 2020; 370: m2915. DOI: 10.1136/bmj.m2915
14. Han Y, Ma H, Suo M, et al. Clinical manifestation, outcomes in pregnant women with COVID-19 and the possibility of vertical transmission: a systematic review of the current data. J Perinat Med 2020; 48 (9): 912–24. DOI: 10.1515/jpm-2020-0431
15. Aviable at: https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/special-populations/pregnancy-data-on-covid-.... Accessed: 19.02.2021
16. Figueiro-Filho EA, Yudin M, Farine D. COVID-19 during pregnancy: an overview of maternal characteristics, clinical symptoms, maternal and neonatal outcomes of 10,996 cases described in 15 countries. J Perinat Med 2020; 48 (9): 900–11. DOI: 10.1515/jpm-2020-0364; PMID: 33001856
17. Jafari M, Pormohammad A, Sheikh Neshin SA, et al. Clinical characteristics and outcomes of pregnant women with COVID-19 and comparison with control patients: A systematic review and meta-analysis. Rev Med Virol 2021: e2208. DOI: 10.1002/rmv.2208; PMID: 33387448
18. Diriba K, Awulachew E, Getu E. The effect of coronavirus infection (SARS-CoV-2, MERS-CoV, and SARS-CoV) during pregnancy and the possibility of vertical maternal-fetal transmission: a systematic review and meta-analysis. Eur J Med Res 2020; 25 (1): 39. DOI: 10.1186/s40001-020-00439-w; PMID: 32887660; PMCID: PMC7471638
19. Dubey P, Reddy SY, Manuel S, Dwivedi AK. Maternal and neonatal characteristics and outcomes among COVID-19 infected women: An updated systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol 2020; 252: 490–501. DOI: 10.1016/j.ejogrb.2020.07.034; PMID: 32795828
20. CDC Interim Guidance for General Population Disaster Shelters During the COVID-19 Pandemic. Aviable at: https://www.cdc.gov/coronavirus/2019-ncov/downloads/Guidance-for-Gen-Pop-Disaster-Shelters-COVID19.p.... Accessed: 01.09.2020.
21. Di Mascio D, Sen C, Saccone G, et al. Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19. J Perinat Med 2020; 48 (9): 950–8. DOI: 10.1515/jpm-2020-0355; PMID: 32975205
________________________________________________
2. Belokrinitskaya T.E., Shapovalov K.G. Influenza and Pregnancy. Moscow: GEOTAR-Media, 2015 (in Russian)
3. Silasi M, Cardenas I, Kwon JY, et al. Viral infections during pregnancy. Am J Reprod Immunol 2015; 73 (3): 199–213. DOI: 10.1111/aji.12355; PMID: 25582523
4. Dashraath P, Wong JLJ, Lim MXK, et al. Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy. Am J Obstet Gynecol 2020; 222 (6): 521–31.
5. Organization of medical care for pregnant women, women in labor, women in labor and newborns with a new coronavirus infection COVID-19. Methodological recommendations. Ministry of Health of Russia. Version 2. 27.05.2020. Aviable at: https://static-3.rosminzdrav.ru/system/attachments/attaches/000/050/533/original/28052020_Preg_COVID.... Accessed: 19.02.2021 (in Russian)
6. Prevention, diagnosis and treatment of new coronavirus infection (COVID-19). The provisional guidelines. Ministry of Health of Russia. Version 9. 26.10.2020. Aviable at: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/052/550/original/МР_COVID-19_%28v9%.... Accessed: 11.01.2021 (in Russian)
7. Filippov O.S., Guseva E.V. Key performance indicators of the obstetric and gynecological service in the Russian Federation in 2019. Moscow, 2020 (in Russian)
8. Belokrinitskaya T.E., Artymuk N.V., Filippov O.S., Shifman E.M. Dynamics of the epidemic process and the course of the COVID-19 in pregnant women of the Far Eastern and Siberian Federal Districts. Gynecology. 2020; 22 (5): 6–11 (in Russian)
9. Zambrano LD, Ellington S, Strid P, et al. Update: Characteristics of Symptomatic Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status – United States, January 22 – October 3, 2020. MMWR Morb Mortal Wkly Rep 2020; 69 (44): 1641–7. DOI: 10.15585/mmwr.mm6944e3; PMID: 33151921
10. Aviable at: https://www.acog.org/clinical/clinical-guidance/practice-advisory/articles/2020/03/novel-coronavirus... Accessed: 19.02.2021
11. Coronavirus (COVID-19) Infection in Pregnancy. Version 12: RCOG. 14.10.2020.
12. Knight M, Bunch K, Vousden N, et al. Characteristics and outcomes of pregnant women admitted to hospital with confirmed infection in UK: national population based cohort study. BMJ 2020; 369: m2107. DOI: 10.1136/bmj.m2107
13. Magee LA, Khalil A, von Dadelszen P. Covid-19: UK Obstetric Surveillance System (UKOSS) study in context. BMJ 2020; 370: m2915. DOI: 10.1136/bmj.m2915
14. Han Y, Ma H, Suo M, et al. Clinical manifestation, outcomes in pregnant women with COVID-19 and the possibility of vertical transmission: a systematic review of the current data. J Perinat Med 2020; 48 (9): 912–24. DOI: 10.1515/jpm-2020-0431
15. Aviable at: https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/special-populations/pregnancy-data-on-covid-.... Accessed: 19.02.2021
16. Figueiro-Filho EA, Yudin M, Farine D. COVID-19 during pregnancy: an overview of maternal characteristics, clinical symptoms, maternal and neonatal outcomes of 10,996 cases described in 15 countries. J Perinat Med 2020; 48 (9): 900–11. DOI: 10.1515/jpm-2020-0364;
PMID: 33001856
17. Jafari M, Pormohammad A, Sheikh Neshin SA, et al. Clinical characteristics and outcomes of pregnant women with COVID-19 and comparison with control patients: A systematic review and meta-analysis. Rev Med Virol 2021: e2208. DOI: 10.1002/rmv.2208; PMID: 33387448
18. Diriba K, Awulachew E, Getu E. The effect of coronavirus infection (SARS-CoV-2, MERS-CoV, and SARS-CoV) during pregnancy and the possibility of vertical maternal-fetal transmission: a systematic review and meta-analysis. Eur J Med Res 2020; 25 (1): 39. DOI: 10.1186/s40001-020-00439-w; PMID: 32887660; PMCID: PMC7471638
19. Dubey P, Reddy SY, Manuel S, Dwivedi AK. Maternal and neonatal characteristics and outcomes among COVID-19 infected women: An updated systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol 2020; 252: 490–501. DOI: 10.1016/j.ejogrb.2020.07.034; PMID: 32795828
20. CDC Interim Guidance for General Population Disaster Shelters During the COVID-19 Pandemic. Aviable at: https://www.cdc.gov/coronavirus/2019-ncov/downloads/Guidance-for-Gen-Pop-Disaster-Shelters-COVID19.p.... Accessed: 01.09.2020.
21. Di Mascio D, Sen C, Saccone G, et al. Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19. J Perinat Med 2020; 48 (9): 950–8. DOI: 10.1515/jpm-2020-0355; PMID: 32975205
Авторы
Т.Е. Белокриницкая*1, Н.В. Артымук2, О.С. Филиппов3, Н.И. Фролова1
1 ФГБОУ ВО «Читинская государственная медицинская академия» Минздрава России, Чита, Россия;
2 ФБГОУ ВО «Кемеровский государственный медицинский университет» Минздрава России, Кемерово, Россия;
3 ФГБОУ ВО «Московский государственный медико-стоматологический университет имени А.И. Евдокимова» Минздрава России, Москва, Россия
*tanbell24@mail.ru
1 Chita State Medical Academy, Chita, Russia;
2 Kemerovo State Medical University, Kemerovo, Russia;
3 Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
*tanbell24@mail.ru
1 ФГБОУ ВО «Читинская государственная медицинская академия» Минздрава России, Чита, Россия;
2 ФБГОУ ВО «Кемеровский государственный медицинский университет» Минздрава России, Кемерово, Россия;
3 ФГБОУ ВО «Московский государственный медико-стоматологический университет имени А.И. Евдокимова» Минздрава России, Москва, Россия
*tanbell24@mail.ru
________________________________________________
1 Chita State Medical Academy, Chita, Russia;
2 Kemerovo State Medical University, Kemerovo, Russia;
3 Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
*tanbell24@mail.ru
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