Нейрофизиологические механизмы боли и ее количественная оценка при эндометриозе

1. Breivik H, Borchgrevink PC, Allen SM, et al. Assessment of pain. Br J Anaesth. 2008;101(1):17-24. DOI:10.1093/bja/aen103 
2. Dijkers M. Comparing quantification of pain severity by verbal rating and numeric rating scales. J Spinal Cord Med. 2010;33(3):232-42. 
DOI:10.1080/10790268.2010.11689700
3. Cleeland CS. The Brief Pain Inventory User Guide. 2009.
4. Melzack R, Katz J. The McGill Pain Questionnaire: Appraisal and current status. In: DC Turk, R Melzack (eds.). Handbook of pain assessment. The Guilford Press, 2001; p. 35-52.
5. Backonja MM. Need for differential assessment tools of neuropathic pain and the deficits of LANSS pain scale. Pain. 2002;98(1-2):229-31. DOI:10.1016/s0304-3959(02)00115-x
6. Юсупова Д.Г., Супонева Н.А., Зимин А.А., и др. Валидация Лидской шкалы оценки нейропатической боли (LANSS) в России. Нервно-мышечные болезни. 2018;8(3):43-50 [Yusupova DG, Suponeva NA, Zimin  AA, et al. Validation of the Leeds Assessment of Neuropathic Symptoms and Signs Pain Scale (LANSS) in Russia. Nervno-myshechnye bolezni. 2018;8 (3):43-50 (in Russian)]. DOI:10.17650/2222-8721-2018-8-3-43-50 
7. Bircan HA, Yalcin GS, Fidanci S, et al. The usefulness and prognostic value of Memorial Symptom Assessment-Short Form and Condensed Memorial Symptom Assessment Scale in assessment of lung cancer patients. Support Care Cancer. 2020;28(4):2005-14. DOI:10.1007/s00520-019-05003-9
8. Stull DE, Wasiak R, Kreif N, et al. Validation of the SF-36 in patients with endometriosis. Qual Life Res. 2014;23(1):103-17. DOI:10.1007/s11136-013-0442-5
9. Wickström K, Edelstam G. Minimal clinically important difference for pain on the VAS scale and the relation to quality of life in women with endometriosis. Sex Reprod Healthc. 2017;13:35-40. DOI:10.1016/j.srhc.2017.05.004
10. Cozzolino M, Coccia ME, Lazzeri G, et al. Variables Associated with Endometriosis-related Pain: A Pilot Study using a Visual Analogue Scale. Rev Bras Ginecol Obstet. 2019;41(3):170-5. DOI:10.1055/s-0039-1679879 
11. Minson FP, Abrão MS, Sardá Júnior J, et al. Importance of quality of life assessment in patients with endometriosis. Rev Bras Ginecol Obstet. 2012;34(1):11-5 (in Portuguese). 
12. Bourdel N, Alves J, Pickering G, et al. Systematic review of endometriosis pain assessment: how to choose a scale? Hum Reprod Update. 2015;21(1):136-52. DOI:10.1093/humupd/dmu046
13. Лисовская Е.В., Хилькевич Е.Г., Чупрынин В.Д., и др. Качество жизни женщин с глубоким инфильтративным эндометриозом. Акушерство и гинекология. 2020;3:116-26 [Lisovskaia EV, Khil'kevich EG, Chuprynin VD, et al. Kachestvo zhizni zhenshchin s glubokim infil'trativnym endometriozom. Akusherstvo i ginekologiia. 2020;3:116-26 (in Russian)]. DOI:10.18565/aig.2020.3.116-126
14. Fabbri E, Villa G, Mabrouk M, et al. McGill Pain Questionnaire: a multi-dimensional verbal scale assessing postoperative changes in pain symptoms associated with severe endometriosis. J Obstet Gynaecol Res. 2009;35(4):753-60. DOI:10.1111/j.1447-0756.2008.00994.x
15. Адамян Л.В., Сонова М.М., Арсланян К.Н., Логинова О.Н. Особенности хронической тазовой боли у пациенток с наружным генитальным эндометриозом. Лечащий врач. 2019;9:83-7 [Adamyan LV, Sonova MM, Arslanyan KN, Loginova ON. Features of chronic pelvic pain in patients with external genital endometriosis. Lechashchii vrach. 2019;9:83-7 (in Russian)]. DOI:10.26295/OS.2019.44.85.018
16. Харченко Ю.А. Адекватная оценка боли – залог ее успешного лечения. Universum: медицина и фармакология. 2014;4(5). Режим доступа: https://7universum.com/ru/med/archive/item/1229. Ссылка активна на 16.11.2021 [Kharchenko IuA. AAdequate assessment of pain is the pledge of successful treatment. Universum: meditsina i farmakologiia. 2014;4(5). Available at: https://7universum.com/ru/med/archive/item/1229. Accessed: 16.11.2021 (in Russian)]. 
17. Данилов А.Б. Ноцицептивный флексорный рефлекс: метод изучения церебральных механизмов боли (обзор). Журнал невропатологии и психиатрии им. С.С. Корсакова. 1996;1:107-12 [Danilov AB. Notsitseptivnyi fleksornyi refleks: metod izucheniia tserebral'nykh mekhanizmov boli (obzor). Zhurnal nevropatologii i psikhiatrii im. S.S.  Korsakova. 1996;1:107-12 (in Russian)]. 
18. France CR, Rhudy JL, McGlone S. Using normalized EMG to define the nociceptive flexion reflex (NFR) threshold: further evaluation of standardized NFR scoring criteria. Pain. 2009;145(1-2):211-8. DOI:10.1016/j.pain.2009.06.022 
19. Willer JC. Nociceptive flexion reflexes as a tool for pain research in man. Adv Neurol. 1983;39:809-27.
20. Джелдубаева Э.Р., Чуян Е.Н. Особенности исследования ноцицептивого флексорного рефлекса в оценке болевой чувствительности (обзор литературы). Ученые записки Крымского федерального университета имени В.И. Вернадского. Биология. Химия. 2011;4(63):57-66 [Dzheldubaeva ER, Chuian EN. Osobennosti issledovaniia notsitseptivogo fleksornogo refleksa v otsenke bolevoi chuvstvitel'nosti (obzor literatury). Uchenye zapiski Krymskogo federal'nogo universiteta imeni V.I. Vernadskogo. Biologiia. Khimiia. 2011;4(63):57-66 (in Russian)].
21. Сапон Н.А., Чеботарева Л.Л. Использование инструментальных методов исследования для оценки нейрофизиологических коррелятов боли. Украинский нейрохирургический журнал. 2004;4 [Sapon NA, Chebotareva LL. Ispol'zovanie instrumental'nykh metodov issledovaniia dlia otsenki neirofiziologicheskikh korreliatov boli. Ukrainian Neurosurgical Journal. 2004;4:69-75 (in Russian)].
22. Anisman H, Zacharko RM. Behavioral and neurochemical consequences associated with stressors. Ann N Y Acad Sci. 1986;467:205-25. DOI:10.1111/j.1749-6632.1986.tb14630.x 
23. Schmidt AP, Böhmer AE, Hansel G, et al. Changes in Purines Concentration in the Cerebrospinal Fluid of Pregnant Women Experiencing Pain During Active Labor. Neurochem Res. 2015;40(11):2262-9. DOI:10.1007/s11064-015-1716-9
24. Fernandes V, Sharma D, Vaidya S, et al. Cellular and molecular mechanisms driving neuropathic pain: recent advancements and challenges. Expert Opin Ther Targets. 2018;22(2):131-42. DOI:10.1080/14728222.2018.1420781 
25. Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell. 2009;139(2):267-84. DOI:10.1016/j.cell.2009.09.028
26. Nicholson K. Pain, cognition and traumatic brain injury. Neurorehabilitation. 2000;14:95-103.
27. Аверченкова А.А. Механизмы формирования «болевой памяти» при хронической боли. РМЖ. 2016;24(7):420-2 [Averchenkova AA. Mekhanizmy formirovaniia “bolevoi pamiati” pri khronicheskoi boli. RMZh. 2016;24(7):420-2 (in Russian)].
28. As-Sanie S, Harris RE, Napadow V, et al. Changes in regional gray matter volume in women with chronic pelvic pain: a voxel-based morphometry study. Pain. 2012;153(5):1006-14. DOI:10.1016/j.pain.2012.01.032
29. Stern J, Jeanmonod D, Sarnthein J. Persistent EEG overactivation in the cortical pain matrix of neurogenic pain patients. Neuroimage. 2006;31(2):721-31. DOI:10.1016/j.neuroimage.2005.12.042
30. Sarnthein J, Stern J, Aufenberg C, et al. Increased EEG power and slowed dominant frequency in patients with neurogenic pain. Brain. 
2006;129(Pt. 1):55-64. DOI:10.1093/brain/awh631
31. Vuckovic A, Hasan MA, Fraser M, et al. Dynamic oscillatory signatures of central neuropathic pain in spinal cord injury. J Pain. 2014;15(6):645-55. DOI:10.1016/j.jpain.2014.02.005 
32. LeBlanc BW, Lii TR, Silverman AE, et al. Cortical theta is increased while thalamocortical coherence is decreased in rat models of acute and chronic pain. Pain. 2014;155(4):773-82. DOI:10.1016/j.pain.2014.01.013
33. Llinás R, Urbano FJ, Leznik E, et al. Rhythmic and dysrhythmic thalamocortical dynamics: GABA systems and the edge effect. Trends Neurosci. 2005;28(6):325-33. DOI:10.1016/j.tins.2005.04.006
34. Van den Broeke EN, Wilder-Smith OH, van Goor H, et al. Patients with Persistent Pain after Breast Cancer Treatment Show Enhanced Alpha Activity in Spontaneous EEG. Pain Med. 2013;14(12):1893-9. DOI:10.1111/pme.12216 
35. Hunter AM, Kwan L, Ercoli LM, et al. Quantitative 
electroencephalography biomarkers of cognitive complaints after adjuvant therapy in breast cancer survivors: a pilot study. Psychooncology. 2014;23(6):713-5. DOI:10.1002/pon.3487
36. Moore HC, Parsons MW, Yue GH, et al. Electroencephalogram power changes as a correlate of chemotherapy-associated fatigue and cognitive dysfunction. Support Care Cancer. 2014;22(8):2127-31. DOI:10.1007/s00520-014-2197-0
37. Drewes AM, Gratkowski M, Sami SA, et al. Is the pain in chronic pancreatitis of neuropathic origin? Support from EEG studies during experimental pain. World J Gastroenterol. 2008;14(25):4020-7. DOI:10.3748/wjg.14.4020
38. Wang Y, Li D, Bao F, et al. Thalamic metabolic alterations with cognitive dysfunction in idiopathic trigeminal neuralgia: a multivoxel spectroscopy study. Neuroradiology. 2014;56(8):685-93. DOI:10.1007/s00234-014-1376-5 
39. Peng W, Babiloni C, Mao Y, Hu Y. Subjective pain perception mediated by alpha rhythms. Biol Psychol. 2015;109:141-50. DOI:10.1016/j.biopsycho.2015.05.004 
40. Dowman R, Rissacher D, Schuckers S. EEG indices of tonic pain-related activity in the somatosensory cortices. Clin Neurophysiol. 2008;119(5):1201-12. DOI:10.1016/j.clinph.2008.01.019 
41. Chang PF, Arendt-Nielsen L, Graven-Nielsen T, Chen AC. Psychophysical and EEG responses to repeated experimental muscle pain in humans: pain intensity encodes EEG activity. Brain Res Bull. 2003;59(6):533-43. DOI:10.1016/s0361-9230(02)00950-4 
42. Chang PF, Arendt-Nielsen L, Chen AC. Comparative cerebral responses to non-painful warm vs. cold stimuli in man: EEG power spectra and coherence. Int J Psychophysiol. 2005;55(1):73-83. DOI:10.1016/j.ijpsycho.2004.06.006
43. Coghill RC, Gilron I, Iadarola MJ. Hemispheric lateralization of somatosensory processing. J Neurophysiol. 2001;85(6):2602-12. DOI:10.1152/jn.2001.85.6.2602 
44. Sitges C, Bornas X, Llabrés J, et al. Linear and nonlinear analyses of EEG dynamics during non-painful somatosensory processing in chronic pain patients. Int J Psychophysiol. 2010;77(2):176-83. DOI:10.1016/j.ijpsycho.2010.05.010
45. Pinheiro ES, de Queirós FC, Montoya P, et al. Electroencephalographic Patterns in Chronic Pain: A Systematic Review of the Literature. Plos ONE. 2016;11(2):e0149085. DOI:10.1371/journal.pone.0149085
46. Wei Y, Liang Y, Lin H, et al. Autonomic nervous system and inflammation interaction in endometriosis-associated pain. J Neuroinflammation. 2020;17(1):80.
DOI:10.1186/s12974-020-01752-1
47. Овсянников В.Г., Бойченко А.Е., Алексеев В.В., Алексеева Н.С. Инициальные механизмы формирования боли. Журнал фундаментальной медицины и биологии. 2015;3:4-12 [Ovsiannikov VG, Boichenko AE, Alekseev VV, Alekseeva NS. Initsial'nye mekhanizmy formirovaniia boli. Zhurnal fundamental'noi meditsiny i biologii. 2015;3:4-12 (in Russian)]. 

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1. Breivik H, Borchgrevink PC, Allen SM, et al. Assessment of pain. Br J Anaesth. 2008;101(1):17-24. DOI:10.1093/bja/aen103 
2. Dijkers M. Comparing quantification of pain severity by verbal rating and numeric rating scales. J Spinal Cord Med. 2010;33(3):232-42. 
DOI:10.1080/10790268.2010.11689700
3. Cleeland CS. The Brief Pain Inventory User Guide. 2009.
4. Melzack R, Katz J. The McGill Pain Questionnaire: Appraisal and current status. In: DC Turk, R Melzack (eds.). Handbook of pain assessment. The Guilford Press, 2001; p. 35-52.
5. Backonja MM. Need for differential assessment tools of neuropathic pain and the deficits of LANSS pain scale. Pain. 2002;98(1-2):229-31. DOI:10.1016/s0304-3959(02)00115-x
6. Yusupova DG, Suponeva NA, Zimin  AA, et al. Validation of the Leeds Assessment of Neuropathic Symptoms and Signs Pain Scale (LANSS) in Russia. Nervno-myshechnye bolezni. 2018;8 (3):43-50 (in Russian). DOI:10.17650/2222-8721-2018-8-3-43-50 
7. Bircan HA, Yalcin GS, Fidanci S, et al. The usefulness and prognostic value of Memorial Symptom Assessment-Short Form and Condensed Memorial Symptom Assessment Scale in assessment of lung cancer patients. Support Care Cancer. 2020;28(4):2005-14. DOI:10.1007/s00520-019-05003-9
8. Stull DE, Wasiak R, Kreif N, et al. Validation of the SF-36 in patients with endometriosis. Qual Life Res. 2014;23(1):103-17. DOI:10.1007/s11136-013-0442-5
9. Wickström K, Edelstam G. Minimal clinically important difference for pain on the VAS scale and the relation to quality of life in women with endometriosis. Sex Reprod Healthc. 2017;13:35-40. DOI:10.1016/j.srhc.2017.05.004
10. Cozzolino M, Coccia ME, Lazzeri G, et al. Variables Associated with Endometriosis-related Pain: A Pilot Study using a Visual Analogue Scale. Rev Bras Ginecol Obstet. 2019;41(3):170-5. DOI:10.1055/s-0039-1679879 
11. Minson FP, Abrão MS, Sardá Júnior J, et al. Importance of quality of life assessment in patients with endometriosis. Rev Bras Ginecol Obstet. 2012;34(1):11-5 (in Portuguese). 
12. Bourdel N, Alves J, Pickering G, et al. Systematic review of endometriosis pain assessment: how to choose a scale? Hum Reprod Update. 2015;21(1):136-52. DOI:10.1093/humupd/dmu046
13. Lisovskaia EV, Khil'kevich EG, Chuprynin VD, et al. Kachestvo zhizni zhenshchin s glubokim infil'trativnym endometriozom. Akusherstvo i ginekologiia. 2020;3:116-26 (in Russian). DOI:10.18565/aig.2020.3.116-126
14. Fabbri E, Villa G, Mabrouk M, et al. McGill Pain Questionnaire: a multi-dimensional verbal scale assessing postoperative changes in pain symptoms associated with severe endometriosis. J Obstet Gynaecol Res. 2009;35(4):753-60. DOI:10.1111/j.1447-0756.2008.00994.x
15. Adamyan LV, Sonova MM, Arslanyan KN, Loginova ON. Features of chronic pelvic pain in patients with external genital endometriosis. Lechashchii vrach. 2019;9:83-7 (in Russian). DOI:10.26295/OS.2019.44.85.018
16. Kharchenko IuA. AAdequate assessment of pain is the pledge of successful treatment. Universum: meditsina i farmakologiia. 2014;4(5). Available at: https://7universum.com/ru/med/archive/item/1229. Accessed: 16.11.2021 (in Russian). 
17. Danilov AB. Notsitseptivnyi fleksornyi refleks: metod izucheniia tserebral'nykh mekhanizmov boli (obzor). Zhurnal nevropatologii i psikhiatrii im. S.S.  Korsakova. 1996;1:107-12 (in Russian). 
18. France CR, Rhudy JL, McGlone S. Using normalized EMG to define the nociceptive flexion reflex (NFR) threshold: further evaluation of standardized NFR scoring criteria. Pain. 2009;145(1-2):211-8. DOI:10.1016/j.pain.2009.06.022 
19. Willer JC. Nociceptive flexion reflexes as a tool for pain research in man. Adv Neurol. 1983;39:809-27.
20. Dzheldubaeva ER, Chuian EN. Osobennosti issledovaniia notsitseptivogo fleksornogo refleksa v otsenke bolevoi chuvstvitel'nosti (obzor literatury). Uchenye zapiski Krymskogo federal'nogo universiteta imeni V.I. Vernadskogo. Biologiia. Khimiia. 2011;4(63):57-66 (in Russian).
21. Sapon NA, Chebotareva LL. Ispol'zovanie instrumental'nykh metodov issledovaniia dlia otsenki neirofiziologicheskikh korreliatov boli. Ukrainian Neurosurgical Journal. 2004;4:69-75 (in Russian).
22. Anisman H, Zacharko RM. Behavioral and neurochemical consequences associated with stressors. Ann N Y Acad Sci. 1986;467:205-25. DOI:10.1111/j.1749-6632.1986.tb14630.x 
23. Schmidt AP, Böhmer AE, Hansel G, et al. Changes in Purines Concentration in the Cerebrospinal Fluid of Pregnant Women Experiencing Pain During Active Labor. Neurochem Res. 2015;40(11):2262-9. DOI:10.1007/s11064-015-1716-9
24. Fernandes V, Sharma D, Vaidya S, et al. Cellular and molecular mechanisms driving neuropathic pain: recent advancements and challenges. Expert Opin Ther Targets. 2018;22(2):131-42. DOI:10.1080/14728222.2018.1420781 
25. Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell. 2009;139(2):267-84. DOI:10.1016/j.cell.2009.09.028
26. Nicholson K. Pain, cognition and traumatic brain injury. Neurorehabilitation. 2000;14:95-103.
27. Averchenkova AA. Mekhanizmy formirovaniia “bolevoi pamiati” pri khronicheskoi boli. RMZh. 2016;24(7):420-2 (in Russian).
28. As-Sanie S, Harris RE, Napadow V, et al. Changes in regional gray matter volume in women with chronic pelvic pain: a voxel-based morphometry study. Pain. 2012;153(5):1006-14. DOI:10.1016/j.pain.2012.01.032
29. Stern J, Jeanmonod D, Sarnthein J. Persistent EEG overactivation in the cortical pain matrix of neurogenic pain patients. Neuroimage. 2006;31(2):721-31. DOI:10.1016/j.neuroimage.2005.12.042
30. Sarnthein J, Stern J, Aufenberg C, et al. Increased EEG power and slowed dominant frequency in patients with neurogenic pain. Brain. 
2006;129(Pt. 1):55-64. DOI:10.1093/brain/awh631
31. Vuckovic A, Hasan MA, Fraser M, et al. Dynamic oscillatory signatures of central neuropathic pain in spinal cord injury. J Pain. 2014;15(6):645-55. DOI:10.1016/j.jpain.2014.02.005 
32. LeBlanc BW, Lii TR, Silverman AE, et al. Cortical theta is increased while thalamocortical coherence is decreased in rat models of acute and chronic pain. Pain. 2014;155(4):773-82. DOI:10.1016/j.pain.2014.01.013
33. Llinás R, Urbano FJ, Leznik E, et al. Rhythmic and dysrhythmic thalamocortical dynamics: GABA systems and the edge effect. Trends Neurosci. 2005;28(6):325-33. DOI:10.1016/j.tins.2005.04.006
34. Van den Broeke EN, Wilder-Smith OH, van Goor H, et al. Patients with Persistent Pain after Breast Cancer Treatment Show Enhanced Alpha Activity in Spontaneous EEG. Pain Med. 2013;14(12):1893-9. DOI:10.1111/pme.12216 
35. Hunter AM, Kwan L, Ercoli LM, et al. Quantitative 
electroencephalography biomarkers of cognitive complaints after adjuvant therapy in breast cancer survivors: a pilot study. Psychooncology. 2014;23(6):713-5. DOI:10.1002/pon.3487
36. Moore HC, Parsons MW, Yue GH, et al. Electroencephalogram power changes as a correlate of chemotherapy-associated fatigue and cognitive dysfunction. Support Care Cancer. 2014;22(8):2127-31. DOI:10.1007/s00520-014-2197-0
37. Drewes AM, Gratkowski M, Sami SA, et al. Is the pain in chronic pancreatitis of neuropathic origin? Support from EEG studies during experimental pain. World J Gastroenterol. 2008;14(25):4020-7. DOI:10.3748/wjg.14.4020
38. Wang Y, Li D, Bao F, et al. Thalamic metabolic alterations with cognitive dysfunction in idiopathic trigeminal neuralgia: a multivoxel spectroscopy study. Neuroradiology. 2014;56(8):685-93. DOI:10.1007/s00234-014-1376-5 
39. Peng W, Babiloni C, Mao Y, Hu Y. Subjective pain perception mediated by alpha rhythms. Biol Psychol. 2015;109:141-50. DOI:10.1016/j.biopsycho.2015.05.004 
40. Dowman R, Rissacher D, Schuckers S. EEG indices of tonic pain-related activity in the somatosensory cortices. Clin Neurophysiol. 2008;119(5):1201-12. DOI:10.1016/j.clinph.2008.01.019 
41. Chang PF, Arendt-Nielsen L, Graven-Nielsen T, Chen AC. Psychophysical and EEG responses to repeated experimental muscle pain in humans: pain intensity encodes EEG activity. Brain Res Bull. 2003;59(6):533-43. DOI:10.1016/s0361-9230(02)00950-4 
42. Chang PF, Arendt-Nielsen L, Chen AC. Comparative cerebral responses to non-painful warm vs. cold stimuli in man: EEG power spectra and coherence. Int J Psychophysiol. 2005;55(1):73-83. DOI:10.1016/j.ijpsycho.2004.06.006
43. Coghill RC, Gilron I, Iadarola MJ. Hemispheric lateralization of somatosensory processing. J Neurophysiol. 2001;85(6):2602-12. DOI:10.1152/jn.2001.85.6.2602 
44. Sitges C, Bornas X, Llabrés J, et al. Linear and nonlinear analyses of EEG dynamics during non-painful somatosensory processing in chronic pain patients. Int J Psychophysiol. 2010;77(2):176-83. DOI:10.1016/j.ijpsycho.2010.05.010
45. Pinheiro ES, de Queirós FC, Montoya P, et al. Electroencephalographic Patterns in Chronic Pain: A Systematic Review of the Literature. Plos ONE. 2016;11(2):e0149085. DOI:10.1371/journal.pone.0149085
46. Wei Y, Liang Y, Lin H, et al. Autonomic nervous system and inflammation interaction in endometriosis-associated pain. J Neuroinflammation. 2020;17(1):80.
DOI:10.1186/s12974-020-01752-1
47. Ovsiannikov VG, Boichenko AE, Alekseev VV, Alekseeva NS. Initsial'nye mekhanizmy formirovaniia boli. Zhurnal fundamental'noi meditsiny i biologii. 2015;3:4-12 (in Russian). 

В.В. Логинов*1, А.В. Вартанов1,2, С.А. Фейгин1, С.В. Павлович1

1 ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии 
имени академика В.И. Кулакова» Минздрава России, Москва, Россия;
2 ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова», Москва, Россия 
*vikloginov@yandex.ru

________________________________________________

Viktor V. Loginov*1, Alexander V. Vartanov1,2, Semen A. Feigin1, Stanislav V. Pavlovich1

1 Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia; 
2 Lomonosov Moscow State University, Moscow, Russia
*vikloginov@yandex.ru