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Постковидный синдром у молодых здоровых женщин: миф или реальность?
Постковидный синдром у молодых здоровых женщин: миф или реальность?
Белокриницкая Т.Е., Фролова Н.И., Мудров В.А., Каргина К.А., Шаметова Е.А., Жамьянова Ч.Ц., Осмонова Ш.Р. Постковидный синдром у молодых здоровых женщин: миф или реальность? Гинекология. 2023;25(3):341–347. DOI: 10.26442/20795696.2023.3.202333
© ООО «КОНСИЛИУМ МЕДИКУМ», 2023 г.
DOI: 10.26442/20795696.2023.3.202333
© ООО «КОНСИЛИУМ МЕДИКУМ», 2023 г.
________________________________________________
DOI: 10.26442/20795696.2023.3.202333
Материалы доступны только для специалистов сферы здравоохранения. Авторизуйтесь или зарегистрируйтесь.
Аннотация
Цель. Оценить частоту и степень выраженности новых стойких симптомов у соматически здоровых молодых женщин после перенесенного COVID-19 и у не заболевших в период пандемии.
Материалы и методы. Основная группа – пациентки, переболевшие в июле–октябре 2021 г. COVID-19, подтвержденным методом полимеразной цепной реакции (n=181); группа сравнения – женщины, не заболевшие в этот период (n=71). Критерии включения: женский пол, возраст 18–35 лет, отсутствие беременности, избытка массы тела/ожирения, сахарного диабета, хронической артериальной гипертензии и других соматических и/или хронических инфекционных заболеваний, предменструального синдрома. Постковидный синдром (ПКС) выявляли на основании симптомов, отсутствовавших до COVID-19, появившихся >4 нед от начала заболевания и длившихся не менее 2 мес, которые не могли объясняться альтернативными диагнозами. Для формирования статистической базы данных использовали первичную медицинскую документацию и интервьюирование пациенток по специальной анкете. Выраженность симптомов оценивали по 10-балльной шкале.
Результаты. Новые стойкие симптомы в период пандемии у молодых исходно соматически здоровых женщин, переболевших COVID-19 и у незаболевших,
зарегистрированы с одинаковой частотой: 96,1 и 93,0% соответственно (отношение шансов – OШ 1,88, 95% доверительный интервал – ДИ 0,58–6,14; pχ2=0,327). Только в группе пациенток с COVID-19 отмечены кашель (43,6%), одышка (26,5%), боли в груди (18,2%), потеря массы тела (18,8%), выпадение волос (60,8%); в группе сравнения – 0,0%; pχ2<0,001. У пациенток с ПКС чаще возникали ухудшение памяти – 49,2% vs 12,7% (ОШ 6,66, 95% ДИ 3,13–14,21; pχ2<0,001); головная боль – 43,1% vs 11,3% (ОШ 5,96, 95% ДИ 2,7–13,17; pχ2<0,001); депрессия – 19,9% vs 8,5% (ОШ 2,69, 95% ДИ 1,08–6,7; pχ2=0,029); миалгия – 31,5% vs 8,5% (ОШ 4,98, 95% ДИ 2,04–12,17; pχ2<0,001). У женщин сравниваемых групп с одинаковой частотой выявлены усталость/быстрая утомляемость (69,0% vs 71,8%; pχ2=0,66), сонливость (54,9% vs 43,6%; pχ2=0,11), сердцебиение (19,7% vs 29,8%; pχ2=0,1), изменение характера менструального цикла (22,5% vs 21,0%; pχ2=0,865), кожные проявления (2,8% vs 6,6%; pχ2=0,24). У перенесших COVID-19 отмечена более выраженная степень ухудшения памяти (4,0 vs 1,0 балла; p<0,001), головной боли (5,0 vs 3,0 балла; p=0,001); миалгии (5,0 vs 1,0 балла; p<0,001), и менее интенсивной оказалась бессонница (3,0 vs 5,0 балла; p=0,004).
Заключение. Симптомы ПКС широко распространены у исходно соматически здоровых женщин раннего репродуктивного возраста. Развитие аналогичных сходных по частоте встречаемости симптомов у не заболевших COVID-19 женщин может быть связано с посттравматическим стрессово-тревожным расстройством. Необходимы дальнейшие междисциплинарные исследования для выявления патофизиологических механизмов развития новых стойких симптомов, возникших у различных возрастных и социальных групп населения в пандемию COVID-19.
Ключевые слова: COVID-19, постковидный синдром, стресс-связанные расстройства, женщины раннего репродуктивного возраста
Materials and methods. The main study group included patients who had PCR-confirmed COVID-19 in July–October 2021 (n=181); the comparison group included women without COVID-19 during this period (n=71). Inclusion criteria: female sex, age 18–35 years, no pregnancy, overweight/obesity, diabetes mellitus, chronic hypertension, premenstrual syndrome, and other somatic and/or chronic infectious diseases. Post-COVID syndrome (PCS) was diagnosed based on symptoms absent before COVID-19, appeared >4 weeks from the disease onset, and lasted at least 2 months, which could not be explained by alternative diagnoses. We used primary medical records and interviewed patients using a special questionnaire to develop a statistical database. The severity of symptoms was assessed using a 10-point scale.
Results. New persistent symptoms during the pandemic in young, initially somatically healthy women with and without COVID-19 were reported with similar frequency: 96.1 and 93.0%, respectively (odds ratio – OR 1.88, 95% confidence interval – CI 0.58–6.14; pχ2=0.327). Only patients with COVID-19 reported cough (43.6%), shortness of breath (26.5%), chest pain (18.2%), weight loss (18.8%), hair loss (60.8%); in the comparison group, these symptoms were not reported; pχ2<0.001. Patients with PCS were more likely to experience memory impairment – 49.2% vs 12.7% (OR 6.66, 95% CI 3.13–14.21; pχ2<0.001); headache – 43.1% vs 11.3% (OR 5.96, 95% CI 2.7–13.17; pχ2<0.001); depression – 19.9% vs 8.5% (OR 2.69, 95% CI 1.08–6.7; pχ2=0.029); myalgia – 31.5% vs 8.5% (OR 4.98, 95% CI 2.04–12.17; pχ2<0.001). Patients of both groups showed similar frequency of fatigue (69.0% vs 71.8%; pχ2=0.66), drowsiness (54.9% vs 43.6%; pχ2=0.11), palpitations (19.7% vs 29.8%; pχ2=0.1), menstrual cycle changes (22.5% vs 21.0%; pχ2=0.865), and skin manifestations (2.8% vs 6.6%; pχ2=0.24). COVID-19 survivors had a more pronounced memory impairment (4.0 vs 1.0 points; p<0.001), headache (5.0 vs 3.0 points; p=0.001), myalgia (5.0 vs 1.0 points; p<0.001) and less severe insomnia (3.0 vs 5.0 points; p=0.004).
Conclusion. The PCS symptoms are common in initially somatically healthy women of early reproductive age. Similar symptoms in women with no history of COVID-19 may be due to post-traumatic stress anxiety disorder. Further interdisciplinary research is needed to identify the pathophysiological mechanisms for the occurrence of new persistent symptoms in different age and social groups during the COVID-19 pandemic.
Keywords: COVID-19, post-COVID syndrome, stress-related disorders, women of early reproductive age
Материалы и методы. Основная группа – пациентки, переболевшие в июле–октябре 2021 г. COVID-19, подтвержденным методом полимеразной цепной реакции (n=181); группа сравнения – женщины, не заболевшие в этот период (n=71). Критерии включения: женский пол, возраст 18–35 лет, отсутствие беременности, избытка массы тела/ожирения, сахарного диабета, хронической артериальной гипертензии и других соматических и/или хронических инфекционных заболеваний, предменструального синдрома. Постковидный синдром (ПКС) выявляли на основании симптомов, отсутствовавших до COVID-19, появившихся >4 нед от начала заболевания и длившихся не менее 2 мес, которые не могли объясняться альтернативными диагнозами. Для формирования статистической базы данных использовали первичную медицинскую документацию и интервьюирование пациенток по специальной анкете. Выраженность симптомов оценивали по 10-балльной шкале.
Результаты. Новые стойкие симптомы в период пандемии у молодых исходно соматически здоровых женщин, переболевших COVID-19 и у незаболевших,
зарегистрированы с одинаковой частотой: 96,1 и 93,0% соответственно (отношение шансов – OШ 1,88, 95% доверительный интервал – ДИ 0,58–6,14; pχ2=0,327). Только в группе пациенток с COVID-19 отмечены кашель (43,6%), одышка (26,5%), боли в груди (18,2%), потеря массы тела (18,8%), выпадение волос (60,8%); в группе сравнения – 0,0%; pχ2<0,001. У пациенток с ПКС чаще возникали ухудшение памяти – 49,2% vs 12,7% (ОШ 6,66, 95% ДИ 3,13–14,21; pχ2<0,001); головная боль – 43,1% vs 11,3% (ОШ 5,96, 95% ДИ 2,7–13,17; pχ2<0,001); депрессия – 19,9% vs 8,5% (ОШ 2,69, 95% ДИ 1,08–6,7; pχ2=0,029); миалгия – 31,5% vs 8,5% (ОШ 4,98, 95% ДИ 2,04–12,17; pχ2<0,001). У женщин сравниваемых групп с одинаковой частотой выявлены усталость/быстрая утомляемость (69,0% vs 71,8%; pχ2=0,66), сонливость (54,9% vs 43,6%; pχ2=0,11), сердцебиение (19,7% vs 29,8%; pχ2=0,1), изменение характера менструального цикла (22,5% vs 21,0%; pχ2=0,865), кожные проявления (2,8% vs 6,6%; pχ2=0,24). У перенесших COVID-19 отмечена более выраженная степень ухудшения памяти (4,0 vs 1,0 балла; p<0,001), головной боли (5,0 vs 3,0 балла; p=0,001); миалгии (5,0 vs 1,0 балла; p<0,001), и менее интенсивной оказалась бессонница (3,0 vs 5,0 балла; p=0,004).
Заключение. Симптомы ПКС широко распространены у исходно соматически здоровых женщин раннего репродуктивного возраста. Развитие аналогичных сходных по частоте встречаемости симптомов у не заболевших COVID-19 женщин может быть связано с посттравматическим стрессово-тревожным расстройством. Необходимы дальнейшие междисциплинарные исследования для выявления патофизиологических механизмов развития новых стойких симптомов, возникших у различных возрастных и социальных групп населения в пандемию COVID-19.
Ключевые слова: COVID-19, постковидный синдром, стресс-связанные расстройства, женщины раннего репродуктивного возраста
________________________________________________
Materials and methods. The main study group included patients who had PCR-confirmed COVID-19 in July–October 2021 (n=181); the comparison group included women without COVID-19 during this period (n=71). Inclusion criteria: female sex, age 18–35 years, no pregnancy, overweight/obesity, diabetes mellitus, chronic hypertension, premenstrual syndrome, and other somatic and/or chronic infectious diseases. Post-COVID syndrome (PCS) was diagnosed based on symptoms absent before COVID-19, appeared >4 weeks from the disease onset, and lasted at least 2 months, which could not be explained by alternative diagnoses. We used primary medical records and interviewed patients using a special questionnaire to develop a statistical database. The severity of symptoms was assessed using a 10-point scale.
Results. New persistent symptoms during the pandemic in young, initially somatically healthy women with and without COVID-19 were reported with similar frequency: 96.1 and 93.0%, respectively (odds ratio – OR 1.88, 95% confidence interval – CI 0.58–6.14; pχ2=0.327). Only patients with COVID-19 reported cough (43.6%), shortness of breath (26.5%), chest pain (18.2%), weight loss (18.8%), hair loss (60.8%); in the comparison group, these symptoms were not reported; pχ2<0.001. Patients with PCS were more likely to experience memory impairment – 49.2% vs 12.7% (OR 6.66, 95% CI 3.13–14.21; pχ2<0.001); headache – 43.1% vs 11.3% (OR 5.96, 95% CI 2.7–13.17; pχ2<0.001); depression – 19.9% vs 8.5% (OR 2.69, 95% CI 1.08–6.7; pχ2=0.029); myalgia – 31.5% vs 8.5% (OR 4.98, 95% CI 2.04–12.17; pχ2<0.001). Patients of both groups showed similar frequency of fatigue (69.0% vs 71.8%; pχ2=0.66), drowsiness (54.9% vs 43.6%; pχ2=0.11), palpitations (19.7% vs 29.8%; pχ2=0.1), menstrual cycle changes (22.5% vs 21.0%; pχ2=0.865), and skin manifestations (2.8% vs 6.6%; pχ2=0.24). COVID-19 survivors had a more pronounced memory impairment (4.0 vs 1.0 points; p<0.001), headache (5.0 vs 3.0 points; p=0.001), myalgia (5.0 vs 1.0 points; p<0.001) and less severe insomnia (3.0 vs 5.0 points; p=0.004).
Conclusion. The PCS symptoms are common in initially somatically healthy women of early reproductive age. Similar symptoms in women with no history of COVID-19 may be due to post-traumatic stress anxiety disorder. Further interdisciplinary research is needed to identify the pathophysiological mechanisms for the occurrence of new persistent symptoms in different age and social groups during the COVID-19 pandemic.
Keywords: COVID-19, post-COVID syndrome, stress-related disorders, women of early reproductive age
Полный текст
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25. Шепелева И.И., Чернышева А.А., Кирьянова Е.М., и др. COVID-19: поражение нервной системы и психологопсихиатрические осложнения. Социальная и клиническая психиатрия. 2020;30(4):76-82 [Shepeleva II, Chernysheva AA, Kiryanova EM, et al. The nervous system damages and psychological and psychiatric complications on the COVID-19 pandemic. Social and clinical psychiatry. 2020;30(4):76-82 (in Russian)].
26. Shan D, Li S, Xu R, et al. Post-COVID-19 human memory impairment: A PRISMA-based systematic review of evidence from brain imaging studies. Front Aging Neurosci. 2022;14:1077384. DOI:10.3389/fnagi.2022.1077384
27. Белокриницкая Т.Е., Фролова Н.И., Колмакова К.А., Шаметова Е.А. Факторы риска и особенности течения COVID-19 у беременных: сравнительный анализ эпидемических вспышек 2020 и 2021 г. Гинекология. 2021;23(5):421-7 [Belokrinitskaya TE Frolova NI, Kolmakova KA, Shametova EA. Risk factors and features of COVID-19 course in pregnant women: a comparative analysis of epidemic outbreaks in 2020 and 2021. Gynecology. 2021;23(5):421-7 (in Russian)]. DOI:10.26442/20795696.2021.5.201107
28. Sharif N, Alzahrani KJ, Ahmed SN, et al. Genomic surveillance, evolution and global transmission of SARS-CoV-2 during 2019–2022. PLoS ONE. 2022;17(8):e0271074. DOI:10.1371/journal.pone.0271074
2. Statement on the fifteenth meeting of the IHR (2005) Emergency Committee on the COVID-19 pandemic. Available at: https://www.who.int/news/item/05-05-2023-statement-on-the-fifteenth-meeting-of-the-international-hea.... Accessed: 06.05.2023.
3. Adamyan LV, Baibarina EN, Filippov OS, et al. Restoration of reproductive health in women who recover from COVID-19. Several aspects. Problemy Reproduktsii. 2021;27(6):30-40 (in Russian). DOI:10.17116/repro2020260416
4. Recommendations for the management of patients with COVID-19 coronavirus infection in the acute phase and with post-COVID syndrome on an outpatient basis. Ed. prof. PA Vorobyev. Problems of standardization in healthcare. 2021;7-8:3-96 (in Russian)]. DOI:10.26347/1607-2502202107-08003-096
5. Baig AM. Chronic COVID syndrome: need for an appropriate medical terminology for long-COVID and COVID long-haulers. J Med Virol. 2021;93(5):2555-6. DOI:10.1002/jmv.26624
6. Silva Andrade B, Siqueira S, de Assis Soares WR, et al. Long-COVID and Post-COVID Health Complications: An Up-to-Date Review on Clinical Conditions and Their Possible Molecular Mechanisms. Viruses. 2021;13(4):700. DOI:10.3390/v13040700
7. Maamar M, Artime A, Pariente E, et al. Post-COVID-19 syndrome, low-grade inflammation and inflammatory markers: a cross-sectional study. Curr Med Res Opin.
2022;38(6):901-9. DOI:10.1080/03007995.2022.2042991
8. COVID-19 rapid guideline: managing the long-term effects of COVID-19 NICE guideline [NG188]Published date:18 December 2020. Available at: https://www.nice.org.uk/guidance/ng188. Accessed: 15.02.2023.
9. Greenhalgh T, Knight M, A'Court C, et al. Management of post-acute COVID-19 in primary care. BMJ. 2020;370:m3026. DOI:10.1136/bmj.m3026
10. Fernández-de-Las-Peñas C, Palacios-Ceña D, Gómez-Mayordomo V, et al. Defining post-COVID symptoms (postacute COVID, long COVID, persistent post-COVID): an integrative classification. Int J Environ Res Public Health. 2021;18(5):2621. DOI:10.3390/ijerph18052621
11. A clinical case definition of post COVID-19 condition by a Delphi consensus 6 October 2021. Available at: https://www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definiti.... Accessed: 15.02.2023.
12. Services and Supports for Longer Term Impacts of COVID. Department of Health and Human Services, Office of the Assistant Secretary for Health. 200 Independence Ave SW, Washington, DC 20201. August 2022. Available at: https://www.covid.gov/assets/files/Services-and-Supports-for-Longer-Term-Impacts-of-COVID-19-0801202.... Accessed: 15.02.2023.
13. Pavli A, Theodoridou M, Maltezou HC. Post-COVID Syndrome: Incidence, Clinical Spectrum, and Challenges for Primary Healthcare Professionals. Arch Med Res. 2021;52(6):575-81.
DOI:10.1016/j.arcmed.2021.03.010
14. Tsampasian V, Elghazaly H, Chattopadhyay R, et al. Risk Factors Associated With Post−COVID-19 Condition: A Systematic Review and Meta-analysis. JAMA Intern Med. 2023;183(6):566-80. DOI:10.1001/jamainternmed.2023.0750
15. Maltezou HC, Pavli A, Tsakris A. Post-COVID Syndrome: An Insight on Its Pathogenesis. Vaccines (Basel). 2021;9(5):497. DOI:10.3390/vaccines9050497
16. Abritalin EY. About the causes and therapy of depressive disorders in COVID-19. Zhurnal nevrologii i psikhiatrii im. SS Korsakova. 2021;121(8):87‑92 (in Russian). DOI:10.17116/jnevro202112108187
17. Ludvigsson JF. Case report and systematic review suggest that children may experience similar long-term effects to adults after clinical COVID-19. Acta Paediatr. 2021;110:914-21. DOI:10.1111/apa.15673
18. Kotova OV, Medvedev VE, Akarachkova ES, Belyaev AA. COVID-19 and stress-related disorders. Zhurnal nevrologii i psikhiatrii im. SS Korsakova. 2021;121(5‑2):122‑8 (in Russian). DOI:10.17116/jnevro2021121052122
19. Taylor S, Landry CA, Paluszek MM et al. COVID stress syndrome: Concept, structure, and correlates. Depress Anxiety. 2020;37(8):706-14. DOI:10.1002/da.23071
20. Belokrinitskaia TE, Liga VF, Kargina RN, Frolova NI. Reproduktivnaia meditsina v svete demograficheskikh tendentsii v sovremennoi Rossii. Versii i kontraversii sovremennoi ginekologii i reproduktivnoi meditsiny: sbornik trudov konferentsii Zabaikal'skogo obshchestva akusherov-ginekologov, Chita, 20–21 marta 2018 g. Pod red. TE Belokrinitskoi, NI Frolovoi. Chita, 2018; p. 6-8 (in Russian).
21. Temporary methodological recommendations prevention, diagnosis and treatment of new coronavirus infection (COVID-19). Ministry of Health of Russia. Version 17 (14.12.2022). Available at: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/061/254/original/%D0%92%D0%9C%D0%A0.... Accessed: 15.02.2023 (in Russian).
22. Sivan M, Taylor S. NICE guideline on long COVID. BMJ. 2020;371:m4938. DOI:10.1136/bmj.m4938
23. Kayaaslan B, Eser F, Kalem AK, et al. Post-COVID syndrome: A single-center questionnaire study on 1007 participants recovered from COVID-19. J Med Virol. 2021;93:6566-74. DOI:10.1002/jmv.27198
24. Organization of medical care for pregnant women, women in labor, women in labor and newborns with a new coronavirus infection COVID-19. Methodological recommendations. Ministry of Health of Russia. Version 5. 28.12.2021. Available at: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/059/052/original/BMP_preg_5.pdf Accessed: 28.01.2023 (in Russian).
25. Shepeleva II, Chernysheva AA, Kiryanova EM, et al. The nervous system damages and psychological and psychiatric complications on the COVID-19 pandemic. Social and clinical psychiatry. 2020;30(4):76-82 (in Russian).
26. Shan D, Li S, Xu R, et al. Post-COVID-19 human memory impairment: A PRISMA-based systematic review of evidence from brain imaging studies. Front Aging Neurosci. 2022;14:1077384. DOI:10.3389/fnagi.2022.1077384
27. Belokrinitskaya TE Frolova NI, Kolmakova KA, Shametova EA. Risk factors and features of COVID-19 course in pregnant women: a comparative analysis of epidemic outbreaks in 2020 and 2021. Gynecology. 2021;23(5):421-7 (in Russian). DOI:10.26442/20795696.2021.5.201107
28. Sharif N, Alzahrani KJ, Ahmed SN, et al. Genomic surveillance, evolution and global transmission of SARS-CoV-2 during 2019–2022. PLoS ONE. 2022;17(8):e0271074. DOI:10.1371/journal.pone.0271074
2. Statement on the fifteenth meeting of the IHR (2005) Emergency Committee on the COVID-19 pandemic. Available at: https://www.who.int/news/item/05-05-2023-statement-on-the-fifteenth-meeting-of-the-international-hea.... Accessed: 06.05.2023.
3. Адамян Л.В., Вечорко В.И., Конышева О.В., и др. Постковидный синдром в акушерстве и репродуктивной медицине. Проблемы репродукции. 2021;27(6):30-40 [Adamyan LV, Baibarina EN, Filippov OS, et al. Restoration of reproductive health in women who recover from COVID-19. Several aspects. Problemy Reproduktsii. 2021;27(6):30-40 (in Russian)]. DOI:10.17116/repro2020260416
4. Рекомендации по ведению больных с коронавирусной инфекцией COVID-19 в острой фазе и при постковидном синдроме в амбулаторных условиях. Под ред. проф. П.А. Воробьева. Проблемы стандартизации в здравоохранении. 2021;7-8:3-96 [Recommendations for the management of patients with COVID-19 coronavirus infection in the acute phase and with post-COVID syndrome on an outpatient basis. Ed. prof. PA Vorobyev. Problems of standardization in healthcare. 2021;7-8:3-96 (in Russian)].
DOI:10.26347/1607-2502202107-08003-096
5. Baig AM. Chronic COVID syndrome: need for an appropriate medical terminology for long-COVID and COVID long-haulers. J Med Virol. 2021;93(5):2555-6. DOI:10.1002/jmv.26624
6. Silva Andrade B, Siqueira S, de Assis Soares WR, et al. Long-COVID and Post-COVID Health Complications: An Up-to-Date Review on Clinical Conditions and Their Possible Molecular Mechanisms. Viruses. 2021;13(4):700. DOI:10.3390/v13040700
7. Maamar M, Artime A, Pariente E, et al. Post-COVID-19 syndrome, low-grade inflammation and inflammatory markers: a cross-sectional study. Curr Med Res Opin.
2022;38(6):901-9. DOI:10.1080/03007995.2022.2042991
8. COVID-19 rapid guideline: managing the long-term effects of COVID-19 NICE guideline [NG188]Published date:18 December 2020. Available at: https://www.nice.org.uk/guidance/ng188. Accessed: 15.02.2023.
9. Greenhalgh T, Knight M, A'Court C, et al. Management of post-acute COVID-19 in primary care. BMJ. 2020;370:m3026. DOI:10.1136/bmj.m3026
10. Fernández-de-Las-Peñas C, Palacios-Ceña D, Gómez-Mayordomo V, et al. Defining post-COVID symptoms (postacute COVID, long COVID, persistent post-COVID): an integrative classification. Int J Environ Res Public Health. 2021;18(5):2621. DOI:10.3390/ijerph18052621
11. A clinical case definition of post COVID-19 condition by a Delphi consensus 6 October 2021. Available at: https://www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definiti.... Accessed: 15.02.2023.
12. Services and Supports for Longer Term Impacts of COVID. Department of Health and Human Services, Office of the Assistant Secretary for Health. 200 Independence Ave SW, Washington, DC 20201. August 2022. Available at: https://www.covid.gov/assets/files/Services-and-Supports-for-Longer-Term-Impacts-of-COVID-19-0801202.... Accessed: 15.02.2023.
13. Pavli A, Theodoridou M, Maltezou HC. Post-COVID Syndrome: Incidence, Clinical Spectrum, and Challenges for Primary Healthcare Professionals. Arch Med Res. 2021;52(6):575-81.
DOI:10.1016/j.arcmed.2021.03.010
14. Tsampasian V, Elghazaly H, Chattopadhyay R, et al. Risk Factors Associated With Post−COVID-19 Condition: A Systematic Review and Meta-analysis. JAMA Intern Med. 2023;183(6):566-80. DOI:10.1001/jamainternmed.2023.0750
15. Maltezou HC, Pavli A, Tsakris A. Post-COVID Syndrome: An Insight on Its Pathogenesis. Vaccines (Basel). 2021;9(5):497. DOI:10.3390/vaccines9050497
16. Абриталин Е.Ю. О причинах возникновения и лечении депрессивных нарушений при COVID-19. Журнал неврологии и психиатрии им. С.С. Корсакова. 2021;121(8):87‑92 [Abritalin EY. About the causes and therapy of depressive disorders in COVID-19. Zhurnal nevrologii i psikhiatrii im. SS Korsakova. 2021;121(8):87‑92 (in Russian)]. DOI:10.17116/jnevro202112108187
17. Ludvigsson JF. Case report and systematic review suggest that children may experience similar long-term effects to adults after clinical COVID-19. Acta Paediatr. 2021;110:914-21. DOI:10.1111/apa.15673
18. Котова О.В., Медведев В.Э., Акарачкова Е.С., Беляев А.А. Ковид-19 и стресс-связанные расстройства. Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски. 2021;121(5‑2):122‑8 [Kotova OV, Medvedev VE, Akarachkova ES, Belyaev AA. COVID-19 and stress-related disorders. Zhurnal nevrologii i psikhiatrii im. SS Korsakova. 2021;121(5‑2):122‑8 (in Russian)]. DOI:10.17116/jnevro2021121052122
19. Taylor S, Landry CA, Paluszek MM et al. COVID stress syndrome: Concept, structure, and correlates. Depress Anxiety. 2020;37(8):706-14. DOI:10.1002/da.23071
20. Белокриницкая Т.Е., Лига В.Ф., Каргина Р.Н., Фролова Н.И. Репродуктивная медицина в свете демографических тенденций в современной России. Версии и контраверсии современной гинекологии и репродуктивной медицины: сборник трудов конференции Забайкальского общества акушеров-гинекологов, Чита, 20–21 марта 2018 г. Под ред. Т.Е. Белокриницкой, Н.И. Фроловой. Чита, 2018; с. 6-8 [Belokrinitskaia TE, Liga VF, Kargina RN, Frolova NI. Reproduktivnaia meditsina v svete demograficheskikh tendentsii v sovremennoi Rossii. Versii i kontraversii sovremennoi ginekologii i reproduktivnoi meditsiny: sbornik trudov konferentsii Zabaikal'skogo obshchestva akusherov-ginekologov, Chita, 20–21 marta 2018 g. Pod red. TE Belokrinitskoi, NI Frolovoi. Chita, 2018; p. 6-8 (in Russian)].
21. Временные методические рекомендации профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19). Минздрав России. Версия 17 (14.12.2022). Режим доступа: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/061/254/original/%D0%92%D0%9C%D0%A0.... Ссылка активна на 15.02.2023 [Temporary methodological recommendations prevention, diagnosis and treatment of new coronavirus infection (COVID-19). Ministry of Health of Russia. Version 17 (14.12.2022). Available at: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/061/254/original/%D0%92%D0%9C%D0%A0.... Accessed: 15.02.2023 (in Russian)].
22. Sivan M, Taylor S. NICE guideline on long COVID. BMJ. 2020;371:m4938. DOI:10.1136/bmj.m4938
23. Kayaaslan B, Eser F, Kalem AK, et al. Post-COVID syndrome: A single-center questionnaire study on 1007 participants recovered from COVID-19. J Med Virol. 2021;93:6566-74. DOI:10.1002/jmv.27198
24. Организация оказания медицинской помощи беременным, роженицам, родильницам и новорожденным при новой коронавирусной инфекции COVID-19. Методические рекомендации. Минздрав России. Версия 5. 28.12.2021. Режим доступа: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/059/052/original/BMP_preg_5.pdf. Ссылка активна на 28.01.2023 [Organization of medical care for pregnant women, women in labor, women in labor and newborns with a new coronavirus infection COVID-19. Methodological recommendations. Ministry of Health of Russia. Version 5. 28.12.2021. Available at: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/059/052/original/BMP_preg_5.pdf Accessed: 28.01.2023 (in Russian)].
25. Шепелева И.И., Чернышева А.А., Кирьянова Е.М., и др. COVID-19: поражение нервной системы и психологопсихиатрические осложнения. Социальная и клиническая психиатрия. 2020;30(4):76-82 [Shepeleva II, Chernysheva AA, Kiryanova EM, et al. The nervous system damages and psychological and psychiatric complications on the COVID-19 pandemic. Social and clinical psychiatry. 2020;30(4):76-82 (in Russian)].
26. Shan D, Li S, Xu R, et al. Post-COVID-19 human memory impairment: A PRISMA-based systematic review of evidence from brain imaging studies. Front Aging Neurosci. 2022;14:1077384. DOI:10.3389/fnagi.2022.1077384
27. Белокриницкая Т.Е., Фролова Н.И., Колмакова К.А., Шаметова Е.А. Факторы риска и особенности течения COVID-19 у беременных: сравнительный анализ эпидемических вспышек 2020 и 2021 г. Гинекология. 2021;23(5):421-7 [Belokrinitskaya TE Frolova NI, Kolmakova KA, Shametova EA. Risk factors and features of COVID-19 course in pregnant women: a comparative analysis of epidemic outbreaks in 2020 and 2021. Gynecology. 2021;23(5):421-7 (in Russian)]. DOI:10.26442/20795696.2021.5.201107
28. Sharif N, Alzahrani KJ, Ahmed SN, et al. Genomic surveillance, evolution and global transmission of SARS-CoV-2 during 2019–2022. PLoS ONE. 2022;17(8):e0271074. DOI:10.1371/journal.pone.0271074
________________________________________________
2. Statement on the fifteenth meeting of the IHR (2005) Emergency Committee on the COVID-19 pandemic. Available at: https://www.who.int/news/item/05-05-2023-statement-on-the-fifteenth-meeting-of-the-international-hea.... Accessed: 06.05.2023.
3. Adamyan LV, Baibarina EN, Filippov OS, et al. Restoration of reproductive health in women who recover from COVID-19. Several aspects. Problemy Reproduktsii. 2021;27(6):30-40 (in Russian). DOI:10.17116/repro2020260416
4. Recommendations for the management of patients with COVID-19 coronavirus infection in the acute phase and with post-COVID syndrome on an outpatient basis. Ed. prof. PA Vorobyev. Problems of standardization in healthcare. 2021;7-8:3-96 (in Russian)]. DOI:10.26347/1607-2502202107-08003-096
5. Baig AM. Chronic COVID syndrome: need for an appropriate medical terminology for long-COVID and COVID long-haulers. J Med Virol. 2021;93(5):2555-6. DOI:10.1002/jmv.26624
6. Silva Andrade B, Siqueira S, de Assis Soares WR, et al. Long-COVID and Post-COVID Health Complications: An Up-to-Date Review on Clinical Conditions and Their Possible Molecular Mechanisms. Viruses. 2021;13(4):700. DOI:10.3390/v13040700
7. Maamar M, Artime A, Pariente E, et al. Post-COVID-19 syndrome, low-grade inflammation and inflammatory markers: a cross-sectional study. Curr Med Res Opin.
2022;38(6):901-9. DOI:10.1080/03007995.2022.2042991
8. COVID-19 rapid guideline: managing the long-term effects of COVID-19 NICE guideline [NG188]Published date:18 December 2020. Available at: https://www.nice.org.uk/guidance/ng188. Accessed: 15.02.2023.
9. Greenhalgh T, Knight M, A'Court C, et al. Management of post-acute COVID-19 in primary care. BMJ. 2020;370:m3026. DOI:10.1136/bmj.m3026
10. Fernández-de-Las-Peñas C, Palacios-Ceña D, Gómez-Mayordomo V, et al. Defining post-COVID symptoms (postacute COVID, long COVID, persistent post-COVID): an integrative classification. Int J Environ Res Public Health. 2021;18(5):2621. DOI:10.3390/ijerph18052621
11. A clinical case definition of post COVID-19 condition by a Delphi consensus 6 October 2021. Available at: https://www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definiti.... Accessed: 15.02.2023.
12. Services and Supports for Longer Term Impacts of COVID. Department of Health and Human Services, Office of the Assistant Secretary for Health. 200 Independence Ave SW, Washington, DC 20201. August 2022. Available at: https://www.covid.gov/assets/files/Services-and-Supports-for-Longer-Term-Impacts-of-COVID-19-0801202.... Accessed: 15.02.2023.
13. Pavli A, Theodoridou M, Maltezou HC. Post-COVID Syndrome: Incidence, Clinical Spectrum, and Challenges for Primary Healthcare Professionals. Arch Med Res. 2021;52(6):575-81.
DOI:10.1016/j.arcmed.2021.03.010
14. Tsampasian V, Elghazaly H, Chattopadhyay R, et al. Risk Factors Associated With Post−COVID-19 Condition: A Systematic Review and Meta-analysis. JAMA Intern Med. 2023;183(6):566-80. DOI:10.1001/jamainternmed.2023.0750
15. Maltezou HC, Pavli A, Tsakris A. Post-COVID Syndrome: An Insight on Its Pathogenesis. Vaccines (Basel). 2021;9(5):497. DOI:10.3390/vaccines9050497
16. Abritalin EY. About the causes and therapy of depressive disorders in COVID-19. Zhurnal nevrologii i psikhiatrii im. SS Korsakova. 2021;121(8):87‑92 (in Russian). DOI:10.17116/jnevro202112108187
17. Ludvigsson JF. Case report and systematic review suggest that children may experience similar long-term effects to adults after clinical COVID-19. Acta Paediatr. 2021;110:914-21. DOI:10.1111/apa.15673
18. Kotova OV, Medvedev VE, Akarachkova ES, Belyaev AA. COVID-19 and stress-related disorders. Zhurnal nevrologii i psikhiatrii im. SS Korsakova. 2021;121(5‑2):122‑8 (in Russian). DOI:10.17116/jnevro2021121052122
19. Taylor S, Landry CA, Paluszek MM et al. COVID stress syndrome: Concept, structure, and correlates. Depress Anxiety. 2020;37(8):706-14. DOI:10.1002/da.23071
20. Belokrinitskaia TE, Liga VF, Kargina RN, Frolova NI. Reproduktivnaia meditsina v svete demograficheskikh tendentsii v sovremennoi Rossii. Versii i kontraversii sovremennoi ginekologii i reproduktivnoi meditsiny: sbornik trudov konferentsii Zabaikal'skogo obshchestva akusherov-ginekologov, Chita, 20–21 marta 2018 g. Pod red. TE Belokrinitskoi, NI Frolovoi. Chita, 2018; p. 6-8 (in Russian).
21. Temporary methodological recommendations prevention, diagnosis and treatment of new coronavirus infection (COVID-19). Ministry of Health of Russia. Version 17 (14.12.2022). Available at: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/061/254/original/%D0%92%D0%9C%D0%A0.... Accessed: 15.02.2023 (in Russian).
22. Sivan M, Taylor S. NICE guideline on long COVID. BMJ. 2020;371:m4938. DOI:10.1136/bmj.m4938
23. Kayaaslan B, Eser F, Kalem AK, et al. Post-COVID syndrome: A single-center questionnaire study on 1007 participants recovered from COVID-19. J Med Virol. 2021;93:6566-74. DOI:10.1002/jmv.27198
24. Organization of medical care for pregnant women, women in labor, women in labor and newborns with a new coronavirus infection COVID-19. Methodological recommendations. Ministry of Health of Russia. Version 5. 28.12.2021. Available at: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/059/052/original/BMP_preg_5.pdf Accessed: 28.01.2023 (in Russian).
25. Shepeleva II, Chernysheva AA, Kiryanova EM, et al. The nervous system damages and psychological and psychiatric complications on the COVID-19 pandemic. Social and clinical psychiatry. 2020;30(4):76-82 (in Russian).
26. Shan D, Li S, Xu R, et al. Post-COVID-19 human memory impairment: A PRISMA-based systematic review of evidence from brain imaging studies. Front Aging Neurosci. 2022;14:1077384. DOI:10.3389/fnagi.2022.1077384
27. Belokrinitskaya TE Frolova NI, Kolmakova KA, Shametova EA. Risk factors and features of COVID-19 course in pregnant women: a comparative analysis of epidemic outbreaks in 2020 and 2021. Gynecology. 2021;23(5):421-7 (in Russian). DOI:10.26442/20795696.2021.5.201107
28. Sharif N, Alzahrani KJ, Ahmed SN, et al. Genomic surveillance, evolution and global transmission of SARS-CoV-2 during 2019–2022. PLoS ONE. 2022;17(8):e0271074. DOI:10.1371/journal.pone.0271074
Авторы
Т.Е. Белокриницкая*, Н.И. Фролова, В.А. Мудров, К.А. Каргина, Е.А. Шаметова, Ч.Ц. Жамьянова, Ш.Р. Осмонова
ФГБОУ ВО «Читинская государственная медицинская академия» Минздрава России, Чита, Россия
*tanbell24@mail.ru
Chita State Medical Academy, Chita, Russia
*tanbell24@mail.ru
ФГБОУ ВО «Читинская государственная медицинская академия» Минздрава России, Чита, Россия
*tanbell24@mail.ru
________________________________________________
Chita State Medical Academy, Chita, Russia
*tanbell24@mail.ru
Цель портала OmniDoctor – предоставление профессиональной информации врачам, провизорам и фармацевтам.