1. Малкоч А.В., Анастасевич Л.А., Боткина А.С. Острые респираторные заболевания и возможности иммуномодулирующей терапии. Лечащий врач. 2008; 8: 58–62. / Malkoch A.V., Anastasevich L.A., Botkina A.S. Ostrye respiratornye zabolevaniia i vozmozhnosti immunomoduliruiushchei terapii. Lechashchii vrach. 2008; 8: 58–62. [in Russian]
2. Лобзин Ю.В. Руководство по инфекционным болезням. СПб.: Фолиант, 2000. / Lobzin Iu.V. Rukovodstvo po infektsionnym bolezniam. SPb.: Foliant, 2000. [in Russian]
3. Mossad SB, Macknin ML, Medendorp SV et al. Zinc gluconate lozenges for treating the common cold: a randomized, double-blind, placebo-controlled study. Ann Intern Med 1996; 125: 81–l.
4. Pratter М. Cough and the Common Cold ACCP Evidence-Based Clinical Practice Guidelines. Chest 2006; 129 (Suppl.): 72S–74S.
5. Busse WW, Gern JE, Dick EC. The role of respiratory viruses in asthma. Ciba Found Symp 1997; 206: 208–13.
6. Friedlander SL, Busse WW. The role of rhinovirus in asthma exacerbations. J Allergy Clin Immunol 2005; 116 (2): 267–73.
7. Челенкова И.Н., Утешев Д.Б., Бунятян Н.Д. Острые и хронические воспалительные заболевания верхних дыхательных путей. Рус. мед. журн. 2010; 18 (30): 1878. / Chelenkova I.N., Uteshev D.B., Buniatian N.D. Ostrye i khronicheskie vospalitel'nye zabolevaniia verkhnikh dykhatel'nykh putei. Rus. med. zhurn. 2010; 18 (30): 1878. [in Russian]
8. Haaheim L, Pattison J, Whitley R. A practical guide to clinical virology. Ed. John Wiley and Sons, 2001.
9. Sakchainanont B, Ruangkanchanasetr S, Chantarojanasiri T et al. Effectiveness of antihistamines in common cold. J Med Assoc Thai 1990; 73: 96–101.
10. Immunostimulants for preventing respiratory tract infection in children. Review. The Cochrane Collaboration. Published by JohnWiley & Sons, Ltd, 2011.
11. Киселев О.И., Маринич И.Г., Сомнина А.А. Грипп и другие респираторные инфекции: эпидемиология, профилактика, диагностика и терапия. СПб., 2004. / Kiselev O.I. Marinich I.G., Somnina A.A. Gripp i drugie respiratornye infektsii: epidemiologiia, profilaktika, diagnostika i terapiia. SPb., 2004. [in Russian]
12. Малашенкова И.К., Дидковский Н.А. Современные подходы к профилактике и лечению ОРВИ и гриппа. Рус. мед. журн. 2006; 14 (27): 1968–73. / Malashenkova I.K., Didkovskii N.A. Sovremennye podkhody k profilaktike i lecheniiu ORVI i grippa. Rus. med. zhurn. 2006; 14 (27): 1968–73. [in Russian]
13. Palache AM. Influenza vaccines. A reappraisal of their use. Drugs 1997; 54: 841–56. 
14. Uphoff H, Cohen JM, Fleming D, Noone A. Harmonisation of national influenza surveillance morbidity data from EISS: a simple index. Euro Surveill 2003; 8 (7): 156–64. 
15. WHO, checklist for influenza pandemic preparedness planning. Geneva, World Health Organization, 2005.
16. Ершов Ф.И., Касьянова Н.В., Полонский В.О. Возможна ли рациональная фармакотерапия гриппа и других ОРВИ? Consilium Medicum. 2003; 5 (6): 59–66. / Ershov F.I., Kas'ianova N.V., Polonskii V.O. Vozmozhna li ratsional'naia farmakoterapiia grippa i drugikh ORVI? Consilium Medicum. 2003; 5 (6): 59–66. [in Russian]
17. Липатова М.К., Социальная значимость ОРВИ и актуальность симптоматического лечения. Рус. мед. журн. 2006; 14 (24): 1569–74. / Lipatova M.K., Sotsial'naia znachimost' ORVI i aktual'nost' simptomaticheskogo lecheniia. Rus. med. zhurn. 2006; 14 (24): 1569–74. [in Russian]
18. Bessler WG, vor dem Esche U, Masihi N. The bacterial extract OM-85 BV protects mice against Influenza and Salmonella infection. Intl Immunopharmacol 2010; 10: 1086–90.
19. Steurer-Stey C, Lagler L, Straub DA et al. Oral purified bacterial extracts in acute respiratory tract infections in childhood: a systematic quantitative review. Eur J Pediatr 2007; 166: 365–76.
20. De Benedetto F, Sevieri G. Prevention of respiratory tract infections with bacterial lysate OM-85 bronchomunal in children and adults: a state of the art. Multidiscip Respir Med 2013; 8 (1): 33.
21. Razi CH, Harmancı K, Abacı A et al. The immunostimulant OM-85 BV prevents wheezing attacks in preschool children. J Allergy Clin Immunol 2010; 126 (4): 763–9.
22. Schaad UB. OM-85 BV, an immunostimulant in pediatric recurrent respiratory tract infections: a systematic review. World J Pediatr 2010; 6 (1): 5–12.
23. DeBaets F, Kint J, Pauwels R, Leroy J. IgG subclass deficiency in children with recurrent bronchitis. Eur J Pediatr 1992; 151: 274–8.
24. Del-Rio-Navarro BE, Espinosa RF, Flenady V, Sienra-Monge JJ. Immunostimulants for preventing respiratory tract infection in children. Cochrane Database Syst Rev 2006; 4: CD004974/
25. Roth M, Keul R, Papakonstantinou E et al. Characterization of intracellular signalling transduction and transcription factors involved in Broncho-Vaxom 
(OM-85 BV) induced expression of interleukin-6 and interleukin-8 in human pulmonary fibroblasts. Eur Respir Rev 1996; 6 (38): 171–5. 
26. Mauël J. Stimulation of immunoprotective mechanisms by OM-85 BV. A review of results from in vivo and in vitro studies. Respiration 1994; 61 (Suppl. 1): 8–15.
27. Rozy A, Chorostowska-Wynimko J. Bacterial immunostimulants-mechanism of action and clinical application in respiratory diseases. Pneumonol Alergol Pol 2008; 76 (5): 353–9.
28. Баранов А.А., Лобзин Ю.В. Федеральные клинические рекомендации по оказанию медицинской помощи детям с острой респираторной вирусной инфекцией (острый назофарингит). http://www.pediatr-russia.ru/sites/default/files/file/kr_onaz.pdf на 22 октября 2015. / Baranov A.A., Lobzin Iu.V. Federal'nye klinicheskie rekomendatsii po okazaniiu meditsinskoi pomoshchi detiam s ostroi respiratornoi virusnoi infektsiei (ostryi nazofaringit). http://www.pediatr-russia.ru/sites/default/files/file/kr_onaz.pdf na 22 oktiabria 2015. [in Russian]
29. Jefferson TO, Tyrrell D. Antivirals for the common cold. Cochrane Database Syst Rev (database online) 2001; 3.
30. Hayden FG, Turner RB, Gwaltney JM et al. Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers. Antimicrob Agents Chemother 2003; 47: 3907–3916l.
31. Turner RB, Wecker MT, Pohl G et al. Efficacy of tremacamra, a soluble intercellular adhesion molecule 1, for experimental rhinovirus infection: a randomized clinical trial. JAMA 1999; 281 (19): 1797–804.
32. Землякова Э.И. и др. Экспертный анализ лечения острых респираторных инфекций участковыми педиатрами. Практ. медицина. Педиатрия. Терапия. 2012; 7 (12). / Zemliakova E.I. i dr. Ekspertnyi analiz lecheniia ostrykh respiratornykh infektsii uchastkovymi pediatrami. Prakt. meditsina. Pediatriia. Terapiia. 2012; 7 (12). [in Russian]
33. Андриянова И.В., Каширцева И.А., Казакова О.Э., Вахрушев С.Г. Исследование микробиоты носоглотки детей с хроническим аденоидитом по данным массспектроскопии по микробным маркерам. Folia Otorhinolaryngologiae 2015; 21 (2): 15–6. / Andriianova I.V., Kashirtseva I.A., Kazakova O.E., Vakhrushev S.G. Issledovanie mikrobioty nosoglotki detei s khronicheskim adenoiditom po dannym massspektroskopii po mikrobnym markeram. Folia Otorhinolaryngologiae 2015; 21 (2): 15–6. [in Russian]
34. Крюков А.И., Лучшева Ю.В., Баландин А.В. и др. Рациональная антибиотикотерапия при ангине и хроническом тонзиллите. Consilium Medicum. 2005; 7 (4): 297–300. / Kriukov A.I., Luchsheva Iu.V., Balandin A.V. i dr. Ratsional'naia antibiotikoterapiia pri angine i khronicheskom tonzillite. Consilium Medicum. 2005; 7 (4): 297–300. [in Russian]
35. Гаращенко Т.И., Богомильский М.Р., Маркова Т.П. Бактериальные иммунокорректоры в профилактике заболеваний верхних дыхательных путей и уха у часто болеющих детей. Consilium Medicum. Педиатрия (Прил.). 2002; 3: 7–14. / Garashchenko T.I., Bogomil'skii M.R., Markova T.P. Bakterial'nye immunokorrektory v profilaktike zabolevanii verkhnikh dykhatel'nykh putei i ukha u chasto boleiushchikh detei. Consilium Medicum. Pediatriia (Pril.). 2002;  3: 7–14. [in Russian]
36. Curley FJ, Irwin RS, Pratter MR et al. Cough and the common cold. Am Rev Respir Dis 1988; 138: 305–11.
37. Płusa T, Nawacka D. Efficacy and tolerance of fenspiride in adult patients with acute respiratory tract infections Pol Merkur Lekarski 1998; 5 (30): 368–71.
38. Дворецкий Л.И., Полевщиков А.В., Соколов А.С. Эффективность противовоспалительной терапии при острых респираторных вирусных инфекциях у взрослых в амбулаторной практике: результаты программы «ЭСКУЛАП». Consilium Medicum 2006; 8 (10). / Dvoretskii L.I., Polevshchikov A.V., Sokolov A.S. Effektivnost' protivovospalitel'noi terapii pri ostrykh respiratornykh virusnykh infektsiiakh u vzroslykh v ambulatornoi praktike: rezul'taty programmy «ESKULAP». Consilium Medicum 2006; 8 (10). [in Russian] 

________________________________________________

1. Malkoch A.V., Anastasevich L.A., Botkina A.S. Ostrye respiratornye zabolevaniia i vozmozhnosti immunomoduliruiushchei terapii. Lechashchii vrach. 2008; 8: 58–62. [in Russian]
2. Lobzin Iu.V. Rukovodstvo po infektsionnym bolezniam. SPb.: Foliant, 2000. [in Russian]
3. Mossad SB, Macknin ML, Medendorp SV et al. Zinc gluconate lozenges for treating the common cold: a randomized, double-blind, placebo-controlled study. Ann Intern Med 1996; 125: 81–l.
4. Pratter М. Cough and the Common Cold ACCP Evidence-Based Clinical Practice Guidelines. Chest 2006; 129 (Suppl.): 72S–74S.
5. Busse WW, Gern JE, Dick EC. The role of respiratory viruses in asthma. Ciba Found Symp 1997; 206: 208–13.
6. Friedlander SL, Busse WW. The role of rhinovirus in asthma exacerbations. J Allergy Clin Immunol 2005; 116 (2): 267–73.
7. Chelenkova I.N., Uteshev D.B., Buniatian N.D. Ostrye i khronicheskie vospalitel'nye zabolevaniia verkhnikh dykhatel'nykh putei. Rus. med. zhurn. 2010; 18 (30): 1878. [in Russian]
8. Haaheim L, Pattison J, Whitley R. A practical guide to clinical virology. Ed. John Wiley and Sons, 2001.
9. Sakchainanont B, Ruangkanchanasetr S, Chantarojanasiri T et al. Effectiveness of antihistamines in common cold. J Med Assoc Thai 1990; 73: 96–101.
10. Immunostimulants for preventing respiratory tract infection in children. Review. The Cochrane Collaboration. Published by JohnWiley & Sons, Ltd, 2011.
11. Kiselev O.I. Marinich I.G., Somnina A.A. Gripp i drugie respiratornye infektsii: epidemiologiia, profilaktika, diagnostika i terapiia. SPb., 2004. [in Russian]
12. Malashenkova I.K., Didkovskii N.A. Sovremennye podkhody k profilaktike i lecheniiu ORVI i grippa. Rus. med. zhurn. 2006; 14 (27): 1968–73. [in Russian]
13. Palache AM. Influenza vaccines. A reappraisal of their use. Drugs 1997; 54: 841–56. 
14. Uphoff H, Cohen JM, Fleming D, Noone A. Harmonisation of national influenza surveillance morbidity data from EISS: a simple index. Euro Surveill 2003; 8 (7): 156–64. 
15. WHO, checklist for influenza pandemic preparedness planning. Geneva, World Health Organization, 2005.
16. Ershov F.I., Kas'ianova N.V., Polonskii V.O. Vozmozhna li ratsional'naia farmakoterapiia grippa i drugikh ORVI? Consilium Medicum. 2003; 5 (6): 59–66. [in Russian]
17. Lipatova M.K., Sotsial'naia znachimost' ORVI i aktual'nost' simptomaticheskogo lecheniia. Rus. med. zhurn. 2006; 14 (24): 1569–74. [in Russian]
18. Bessler WG, vor dem Esche U, Masihi N. The bacterial extract OM-85 BV protects mice against Influenza and Salmonella infection. Intl Immunopharmacol 2010; 10: 1086–90.
19. Steurer-Stey C, Lagler L, Straub DA et al. Oral purified bacterial extracts in acute respiratory tract infections in childhood: a systematic quantitative review. Eur J Pediatr 2007; 166: 365–76.
20. De Benedetto F, Sevieri G. Prevention of respiratory tract infections with bacterial lysate OM-85 bronchomunal in children and adults: a state of the art. Multidiscip Respir Med 2013; 8 (1): 33.
21. Razi CH, Harmancı K, Abacı A et al. The immunostimulant OM-85 BV prevents wheezing attacks in preschool children. J Allergy Clin Immunol 2010; 126 (4): 763–9.
22. Schaad UB. OM-85 BV, an immunostimulant in pediatric recurrent respiratory tract infections: a systematic review. World J Pediatr 2010; 6 (1): 5–12.
23. DeBaets F, Kint J, Pauwels R, Leroy J. IgG subclass deficiency in children with recurrent bronchitis. Eur J Pediatr 1992; 151: 274–8.
24. Del-Rio-Navarro BE, Espinosa RF, Flenady V, Sienra-Monge JJ. Immunostimulants for preventing respiratory tract infection in children. Cochrane Database Syst Rev 2006; 4: CD004974/
25. Roth M, Keul R, Papakonstantinou E et al. Characterization of intracellular signalling transduction and transcription factors involved in Broncho-Vaxom 
(OM-85 BV) induced expression of interleukin-6 and interleukin-8 in human pulmonary fibroblasts. Eur Respir Rev 1996; 6 (38): 171–5. 
26. Mauël J. Stimulation of immunoprotective mechanisms by OM-85 BV. A review of results from in vivo and in vitro studies. Respiration 1994; 61 (Suppl. 1): 8–15.
27. Rozy A, Chorostowska-Wynimko J. Bacterial immunostimulants-mechanism of action and clinical application in respiratory diseases. Pneumonol Alergol Pol 2008; 76 (5): 353–9.
28. Baranov A.A., Lobzin Iu.V. Federal'nye klinicheskie rekomendatsii po okazaniiu meditsinskoi pomoshchi detiam s ostroi respiratornoi virusnoi infektsiei (ostryi nazofaringit). http://www.pediatr-russia.ru/sites/default/files/file/kr_onaz.pdf na 22 oktiabria 2015. [in Russian]
29. Jefferson TO, Tyrrell D. Antivirals for the common cold. Cochrane Database Syst Rev (database online) 2001; 3.
30. Hayden FG, Turner RB, Gwaltney JM et al. Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers. Antimicrob Agents Chemother 2003; 47: 3907–3916l.
31. Turner RB, Wecker MT, Pohl G et al. Efficacy of tremacamra, a soluble intercellular adhesion molecule 1, for experimental rhinovirus infection: a randomized clinical trial. JAMA 1999; 281 (19): 1797–804.
32. Zemliakova E.I. i dr. Ekspertnyi analiz lecheniia ostrykh respiratornykh infektsii uchastkovymi pediatrami. Prakt. meditsina. Pediatriia. Terapiia. 2012; 7 (12). [in Russian]
33. Andriianova I.V., Kashirtseva I.A., Kazakova O.E., Vakhrushev S.G. Issledovanie mikrobioty nosoglotki detei s khronicheskim adenoiditom po dannym massspektroskopii po mikrobnym markeram. Folia Otorhinolaryngologiae 2015; 21 (2): 15–6. [in Russian]
34. Kriukov A.I., Luchsheva Iu.V., Balandin A.V. i dr. Ratsional'naia antibiotikoterapiia pri angine i khronicheskom tonzillite. Consilium Medicum. 2005; 7 (4): 297–300. [in Russian]
35. Garashchenko T.I., Bogomil'skii M.R., Markova T.P. Bakterial'nye immunokorrektory v profilaktike zabolevanii verkhnikh dykhatel'nykh putei i ukha u chasto boleiushchikh detei. Consilium Medicum. Pediatriia (Pril.). 2002;  3: 7–14. [in Russian]
36. Curley FJ, Irwin RS, Pratter MR et al. Cough and the common cold. Am Rev Respir Dis 1988; 138: 305–11.
37. Płusa T, Nawacka D. Efficacy and tolerance of fenspiride in adult patients with acute respiratory tract infections Pol Merkur Lekarski 1998; 5 (30): 368–71.
38. Dvoretskii L.I., Polevshchikov A.V., Sokolov A.S. Effektivnost' protivovospalitel'noi terapii pri ostrykh respiratornykh virusnykh infektsiiakh u vzroslykh v ambulatornoi praktike: rezul'taty programmy «ESKULAP». Consilium Medicum 2006; 8 (10). [in Russian] 

М.А.Рябова*

ГБОУ ВПО Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова Минздрава России. 197022, Россия, Санкт-Петербург, ул. Льва Толстого, д. 6/8
*marinaryabova@mail.ru

________________________________________________

M.A.Ryabova*

I.M.Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation. 197022, Russian Federation, Saint Petersburg, ul. L'va Tolstogo, d. 6/8
*marinaryabova@mail.ru