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Возможности цефалоспорина III поколения (цефиксима) в терапии инфекций ЛОР-органов у детей
Возможности цефалоспорина III поколения (цефиксима) в терапии инфекций ЛОР-органов у детей
Егорова О.А. Возможности цефалоспорина III поколения (цефиксима) в терапии инфекций ЛОР-органов у детей. Consilium Medicum. Педиатрия (Прил.). 2016; 1: 54–59.
Consilium Medicum. Pediatrics (Suppl.). 2016; 1: 54–59.
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Consilium Medicum. Pediatrics (Suppl.). 2016; 1: 54–59.
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Аннотация
В статье представлены сведения о распространенности и этиологии инфекций ЛОР-органов у детей. Рассмотрены принципы рационального выбора антибактериальных препаратов с учетом чувствительности основных возбудителей в оториноларингологии. Особое внимание уделено возможности применения при данном заболевании цефалоспоринов и, в частности, цефиксима (Панцеф) – перорального цефалоспорина III поколения, сочетающего широкий спектр антимикробной активности, хорошие фармакокинетические свойства, благоприятный профиль переносимости и удобство применения (1 раз в сутки). Накопленный к настоящему времени опыт лечения препаратом Панцеф рекомендует его к широкому использованию в оториноларингологии.
Ключевые слова: ЛОР-инфекции, антибактериальная терапия, цефалоспорины, цефиксим, Панцеф.
Key words: upper respiratory infection, antibiotic therapy, cephalosporins, cefixime, Pantsef.
Ключевые слова: ЛОР-инфекции, антибактериальная терапия, цефалоспорины, цефиксим, Панцеф.
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Key words: upper respiratory infection, antibiotic therapy, cephalosporins, cefixime, Pantsef.
Полный текст
Список литературы
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31. Dongre N, Ghai H, Kulkarni S et al. Mumbai 400022 Study of efficacy and tolerability of cefixime in sinusitis. Indian Practitioner 2002; 55 (2): 87–91.
32. Leibovitz E, Jacobs MR, Dagan R. Haemophilus influenzae: A significant Pathogen in Acute Otitis Media. Pediatr Infect Dis J 2004; 23 (12): 1142–52.
33. Dabernat H, Geslin P, Megraud F et al. Effects of cefixime or co-amoxiclav treatment on nasopharyngeal carriage of Streptococcus pneumoniae and Haemophilus influenzae in children with acute otitis media. Antimicrob Chemother J 1998; 41 (2): 253–8.
34. Leggett NJ, Caravaggio C, Rybak MJ. Cefixime. DICP Ann Pharmacother 1990; 24: 489–95. [PubMed]
35. Johnson CE, Carlin SA, Super DM et al. Cefixime compared with amoxicillin for treatment of acute otitis media. J Pediatr 1991; 119: 117–22. [PubMed]
36. Howie VM, Owen MJ. Bacteriologic and clinical efficacy of cefixime compared with amoxicillin in acute otitis media. Pediatr Infect Dis J 1987; 6: 989–91. [PubMed]
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38. Bluestone CD. Review of cefixime in the treatment of otitis media in infants and children. Pediatr Infect Dis J 1993; 12: 75–82. [PubMed]
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2. Kamanin E.I., Stetsiuk O.U. Infektsii verkhnikh dykhatel'nykh putei i LOR-organov. Prakticheskoe rukovodstvo po antiinfektsionnoi khimioterapii. Pod red. L.S.Strachunskogo, Iu.B.Belousova, S.N.Kozlova. Smolensk: MAKMAKh, 2007; s. 248–58. [in Russian]
3. Sereda E.V., Katosova L.K., Volkov I.K. Effektivnost' tsefalosporina III pokoleniia tsefiksima (supraksa) pri zabolevaniiakh organov dykhaniia u detei. Lechashchii vrach. 2004; 1: 30–4. [in Russian]
4. Beloborodova N.V. K voprosu ob in"ektsiiakh antibiotikov v praktike uchastkovogo pediatra. Detskii doktor. 1999; 4: 18–21. [in Russian]
5. Ushkalova E.A. Azitromitsin pri infektsiiakh verkhnikh dykhatel'nykh putei i LOR-organov. Farmateka. 2006; 16: 37–44. [in Russian]
6. Suvorova M.P., Iakovlev S.V. Sovremennoe znachenie peroral'nykh tsefalosporinov. Consillium Medicum. 2002; 4 (4): 358–61. [in Russian]
7. Gurov A.V. Supraks v lechenii ostroi gnoinoi patologii LOR-organov. RMZh. 2007; 15 (18): 1343–6. [in Russian]
8. Nosulia E.V., Kim I.A. Ostryi rinosinusit v ambulatornoi praktike. Sonsilium Medicum. 2005; 7 (4): 300–5. [in Russian]
9. Karpishchenko S.A., Kolesnikova O.M. Ostroe vospalenie nebnykh mindalin: prichiny i vozmozhnosti lecheniia. Сonsilium Medicum. Pediatrics (Suppl.). 2014; 4: 28–30. [in Russian]
10. Geppe N.A., Dronov I.A., Maliavina U.S., Afonina E.Iu. Primenenie tsefiksima dlia empiricheskoi terapii vnebol'nichnykh infektsii dykhatel'nykh putei u detei. Pediatriia. 2010; 89: 108–13. [in Russian]
11. Harrison CJ, Chartrand SA, Pichichero ME. Microbiologic and clinical aspects of a trial of once daily cefixime compared with twice daily cefaclor for treatment of acute otitis media in infants and children. Pediatr Infect Dis J 1993; 12: 62–9.
12. Gooch WM 3rd, Philips A, Rhoades R et al. Comparison of the efficacy, safety and acceptability of cefixime and amoxicillin/clavulanate in acute otitis media. Pediatr Infect Dis J 1997; 16 (2 Suppl.): 21–4.
13. Belov B.S. Tsefiksim v terapii bakterial'nykh infektsii. RMZh. 2013 (3). [in Russian]
14. Paniakina M.A., Ovchinnikov A.Iu., Miroshnichenko N.A. O tselesoobraznosti primeneniia tsefiksima dlia lecheniia bol'nykh ostrym bakterial'nym rinosinusitom. Farmateka. 2013; 4. [in Russian]
15. Fokin A.A. Rol' tsefalosporinov v terapii vnebol'nichnykh infektsii nizhnikh i verkhnikh otdelov dykhatel'nykh putei (na osnove dannykh po chuvstvitel'nosti vozbuditelei v Rossii). Klin. mikrobiologiia i antimikrobnaia khimioterapiia. 2010; 12 (2): 146–53. [in Russian]
16. Hakim HE, Malik AC, Aronyk K et al. The prevalence of intracranial complications in pediatric frontal sinusitis. Int J Pediatr Otorhinolaryngol 2006; 70 (8): 1383–7.
17. Chow AW, Benninger MS, Brook I et al. Infectious Diseases Society of America. IDSA clinical practice guideline for acute bacterial rhinosinusitis in children and adults. Clin Infect Dis 2012; 54 (8): e72–e112.
18. Brooks I, Gooch WM 3rd, Jenkins SG et al. Medical management of acute bacterial sinusitis. Recommendations of a clinical advisory committee on pediatric and adult sinusitis. Ann Otol Rhinol Laryngol Suppl 2000; 182: 2–20.
19. EAACI Position Paper on Rhinosinusitis and Nasal Polyps Executive Summary. Allergy 2005; 60: 583–601.
20. Dongre N, Ghai H, Kulkarni S et al. Study of efficacy and tolerability of cefixime in sinusitis. Indian Practitioner 2002; 55 (2): 87–91.
21. Verhoef J, Gillissen A. Resistant Haemophilus influenzae in community-acquired respiratory tract infections: a role for cefixime. Int J Antimicrob Agents 2003; 21: 501–9.
22. McCormickс DP. Nonsevere Acute Otitis Media: A Clinical Trial Comparing Outcomes of Watchful Waiting Versus Immediate Antibiotic Treatment. Pediatrics 2005; 115: 1455–65.
23. McEwen LN, Farjo R, Foxman B. Antibiotic prescribing for otitis media: how well does it match published guidelines? Pharmacoepidemiol Drug Safety 2003; 12: 213–9.
24. American Academy of Pediatrics and American Academy of Family Physicians. Subcommittee on management of acute otitis media: clinical practice quideline: diagnosis and management of acute otitis media. Pediatrics 2004; 113: 1451–65.
25. Kozlov R.S. Pnevmokokki: uroki proshlogo – vzgliad v budushchee. Smolensk: MAKMAKh, 2010. [in Russian]
26. Sidorenko S.V. Tendentsii v rasprostranenii antibiotikorezistentnosti sredi vozbuditelei vnebol'nichnykh infektsii na territorii Rossiiskoi Federatsii. Consilium Medicum. 2007; 9 (1). [in Russian]
27. Kozlov R.S., Sivaia O.V., Krechikova O.I. i dr. Dinamika rezistentnosti Streptococcus pneumoniae k antibiotikam v Rossii za period 1999–2009 gg. (Rezul'taty mnogotsentrovogo prospektivnogo issledovaniia PeGAS). Klin. mikrobiologiia i antimikrobnaia khimioterapiia. 2010; 12 (4): 329–41. [in Russian]
28. Stone JW, Linong G, Andrews JM et al. Cefixime, invitro activity, pharmacokinetics and tissue penetration. J Antimicrob Chemother 1989; 23: 221–8.
29. Guchev I.A., Rafal'skii V.V., Melekhina E.V. Rol' tsefiksima v terapii obostreniia khronicheskoi obstruktivnoi bolezni legkikh. Klin. mikrobiologiia i antimikrobnaia khimioterapiia. 2008; 10 (3): 271–89. [in Russian]
30. Endre L. Cefixime in the Treatment of Respiratory and Urinary Tract Infections. Chemotherapy 1998; 44: 31–4.
31. Dongre N, Ghai H, Kulkarni S et al. Mumbai 400022 Study of efficacy and tolerability of cefixime in sinusitis. Indian Practitioner 2002; 55 (2): 87–91.
32. Leibovitz E, Jacobs MR, Dagan R. Haemophilus influenzae: A significant Pathogen in Acute Otitis Media. Pediatr Infect Dis J 2004; 23 (12): 1142–52.
33. Dabernat H, Geslin P, Megraud F et al. Effects of cefixime or co-amoxiclav treatment on nasopharyngeal carriage of Streptococcus pneumoniae and Haemophilus influenzae in children with acute otitis media. Antimicrob Chemother J 1998; 41 (2): 253–8.
34. Leggett NJ, Caravaggio C, Rybak MJ. Cefixime. DICP Ann Pharmacother 1990; 24: 489–95. [PubMed]
35. Johnson CE, Carlin SA, Super DM et al. Cefixime compared with amoxicillin for treatment of acute otitis media. J Pediatr 1991; 119: 117–22. [PubMed]
36. Howie VM, Owen MJ. Bacteriologic and clinical efficacy of cefixime compared with amoxicillin in acute otitis media. Pediatr Infect Dis J 1987; 6: 989–91. [PubMed]
37. Rodriguez WJ, Khan W, Sait T et al. Cefixime vs cefaclor in the treatment of acute otitis media in children: a randomized, comparative study. Pediatr Infect Dis
J 1993; 12: 70–4. [PubMed]
38. Bluestone CD. Review of cefixime in the treatment of otitis media in infants and children. Pediatr Infect Dis J 1993; 12: 75–82. [PubMed]
39. McIsaac WJ, Kellner JD, Aufricht P et al. Empirical validation of guidelines for the management of pharyngitis in children and adults. JAMA 2004; 291: 1587–95.
40. Strachunskii L.S., Kozlov S.N. Sovremennaia antimikrobnaia khimioterapiia. Rukovodstvo dlia vrachei. M.: Borges, 2002. [in Russian]
41. Brook I, Foote PA. Efficacy of penicillin versus cefdinir in eradication of group A streptococci and tonsillar flora. Antimicrob Agents Chemother 2005; 49 (11): 4787–8.
42. Casey JR, Pichichero ME. Meta-analysis of cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis in children. Pediatrics 2004; 113 (4): 866–82.
43. Altamimi S, Khalil A, Khalaiwi KA et al. Short versus standard duration antibiotic therapy for acute streptococcal pharyngitis in children. Cochrane Database Syst Rev 2009; 21 (1): CD004872.
44. Adam D, Hostalek U, Tröster K. 5-day therapy of bacterial pharyngitis and tonsillitis with cefixime. Comparison with 10 day treatment with penicillin V. Klin Padiatr 1996; 208 (5): 310–3.
45. Geppe N.A., Dronov I.A., Maliavina U.S., Afonina E.Iu. Primenenie tsefiksima dlia empiricheskoi terapii vnebol'nichnykh infektsii dykhatel'nykh putei u detei. Pediatriia. 2010; 6: 108–13. [in Russian]
46. Ludwig E, Thege MK, Arr M et al. Resistance of some selected pathogens to antimicrobials in Hungary. Int J Antimicrob Agents 1995; 6 (2): 99–102.
2. Каманин Е.И., Стецюк О.У. Инфекции верхних дыхательных путей и ЛОР-органов. Практическое руководство по антиинфекционной химиотерапии. Под ред. Л.С.Страчунского, Ю.Б.Белоусова, С.Н.Козлова. Смоленск: МАКМАХ, 2007; с. 248–58. / Kamanin E.I., Stetsiuk O.U. Infektsii verkhnikh dykhatel'nykh putei i LOR-organov. Prakticheskoe rukovodstvo po antiinfektsionnoi khimioterapii. Pod red. L.S.Strachunskogo, Iu.B.Belousova, S.N.Kozlova. Smolensk: MAKMAKh, 2007; s. 248–58. [in Russian]
3. Середа Е.В., Катосова Л.К., Волков И.К. Эффективность цефалоспорина III поколения цефиксима (супракса) при заболеваниях органов дыхания у детей. Лечащий врач. 2004; 1: 30–4. / Sereda E.V., Katosova L.K., Volkov I.K. Effektivnost' tsefalosporina III pokoleniia tsefiksima (supraksa) pri zabolevaniiakh organov dykhaniia u detei. Lechashchii vrach. 2004; 1: 30–4. [in Russian]
4. Белобородова Н.В. К вопросу об инъекциях антибиотиков в практике участкового педиатра. Детский доктор. 1999; 4: 18–21. / Beloborodova N.V. K voprosu ob in"ektsiiakh antibiotikov v praktike uchastkovogo pediatra. Detskii doktor. 1999; 4: 18–21. [in Russian]
5. Ушкалова Е.А. Азитромицин при инфекциях верхних дыхательных путей и ЛОР-органов. Фарматека. 2006; 16: 37–44. / Ushkalova E.A. Azitromitsin pri infektsiiakh verkhnikh dykhatel'nykh putei i LOR-organov. Farmateka. 2006; 16: 37–44. [in Russian]
6. Суворова М.П., Яковлев С.В. Современное значение пероральных цефалоспоринов. Consillium Medicum. 2002; 4 (4): 358–61. / Suvorova M.P., Iakovlev S.V. Sovremennoe znachenie peroral'nykh tsefalosporinov. Consillium Medicum. 2002; 4 (4): 358–61. [in Russian]
7. Гуров А.В. Супракс в лечении острой гнойной патологии ЛОР-органов. РМЖ. 2007; 15 (18): 1343–6. / Gurov A.V. Supraks v lechenii ostroi gnoinoi patologii LOR-organov. RMZh. 2007; 15 (18): 1343–6. [in Russian]
8. Носуля Е.В., Ким И.А. Острый риносинусит в амбулаторной практике. Сonsilium Medicum. 2005; 7 (4): 300–5. / Nosulia E.V., Kim I.A. Ostryi rinosinusit v ambulatornoi praktike. Sonsilium Medicum. 2005; 7 (4): 300–5. [in Russian]
9. Карпищенко С.А., Колесникова О.М. Острое воспаление небных миндалин: причины и возможности лечения. Сonsilium Medicum. Педиатрия (Прил.). 2014; 4: 28–30. / Karpishchenko S.A., Kolesnikova O.M. Ostroe vospalenie nebnykh mindalin: prichiny i vozmozhnosti lecheniia. Сonsilium Medicum. Pediatrics (Suppl.). 2014; 4: 28–30. [in Russian]
10. Геппе Н.А., Дронов И.А., Малявина У.С., Афонина Е.Ю. Применение цефиксима для эмпирической терапии внебольничных инфекций дыхательных путей у детей. Педиатрия. 2010; 89: 108–13. / Geppe N.A., Dronov I.A., Maliavina U.S., Afonina E.Iu. Primenenie tsefiksima dlia empiricheskoi terapii vnebol'nichnykh infektsii dykhatel'nykh putei u detei. Pediatriia. 2010; 89: 108–13. [in Russian]
11. Harrison CJ, Chartrand SA, Pichichero ME. Microbiologic and clinical aspects of a trial of once daily cefixime compared with twice daily cefaclor for treatment of acute otitis media in infants and children. Pediatr Infect Dis J 1993; 12: 62–9.
12. Gooch WM 3rd, Philips A, Rhoades R et al. Comparison of the efficacy, safety and acceptability of cefixime and amoxicillin/clavulanate in acute otitis media. Pediatr Infect Dis J 1997; 16 (2 Suppl.): 21–4.
13. Белов Б.С. Цефиксим в терапии бактериальных инфекций. РМЖ. 2013 (3). / Belov B.S. Tsefiksim v terapii bakterial'nykh infektsii. RMZh. 2013 (3). [in Russian]
14. Панякина М.А., Овчинников А.Ю., Мирошниченко Н.А. О целесообразности применения цефиксима для лечения больных острым бактериальным риносинуситом. Фарматека. 2013; 4. / Paniakina M.A., Ovchinnikov A.Iu., Miroshnichenko N.A. O tselesoobraznosti primeneniia tsefiksima dlia lecheniia bol'nykh ostrym bakterial'nym rinosinusitom. Farmateka. 2013; 4. [in Russian]
15. Фокин А.А. Роль цефалоспоринов в терапии внебольничных инфекций нижних и верхних отделов дыхательных путей (на основе данных по чувствительности возбудителей в России). Клин. микробиология и антимикробная химиотерапия. 2010; 12 (2): 146–53. / Fokin A.A. Rol' tsefalosporinov v terapii vnebol'nichnykh infektsii nizhnikh i verkhnikh otdelov dykhatel'nykh putei (na osnove dannykh po chuvstvitel'nosti vozbuditelei v Rossii). Klin. mikrobiologiia i antimikrobnaia khimioterapiia. 2010; 12 (2): 146–53. [in Russian]
16. Hakim HE, Malik AC, Aronyk K et al. The prevalence of intracranial complications in pediatric frontal sinusitis. Int J Pediatr Otorhinolaryngol 2006; 70 (8): 1383–7.
17. Chow AW, Benninger MS, Brook I et al. Infectious Diseases Society of America. IDSA clinical practice guideline for acute bacterial rhinosinusitis in children and adults. Clin Infect Dis 2012; 54 (8): e72–e112.
18. Brooks I, Gooch WM 3rd, Jenkins SG et al. Medical management of acute bacterial sinusitis. Recommendations of a clinical advisory committee on pediatric and adult sinusitis. Ann Otol Rhinol Laryngol Suppl 2000; 182: 2–20.
19. EAACI Position Paper on Rhinosinusitis and Nasal Polyps Executive Summary. Allergy 2005; 60: 583–601.
20. Dongre N, Ghai H, Kulkarni S et al. Study of efficacy and tolerability of cefixime in sinusitis. Indian Practitioner 2002; 55 (2): 87–91.
21. Verhoef J, Gillissen A. Resistant Haemophilus influenzae in community-acquired respiratory tract infections: a role for cefixime. Int J Antimicrob Agents 2003; 21: 501–9.
22. McCormickс DP. Nonsevere Acute Otitis Media: A Clinical Trial Comparing Outcomes of Watchful Waiting Versus Immediate Antibiotic Treatment. Pediatrics 2005; 115: 1455–65.
23. McEwen LN, Farjo R, Foxman B. Antibiotic prescribing for otitis media: how well does it match published guidelines? Pharmacoepidemiol Drug Safety 2003; 12: 213–9.
24. American Academy of Pediatrics and American Academy of Family Physicians. Subcommittee on management of acute otitis media: clinical practice quideline: diagnosis and management of acute otitis media. Pediatrics 2004; 113: 1451–65.
25. Козлов Р.С. Пневмококки: уроки прошлого – взгляд в будущее. Смоленск: МАКМАХ, 2010. / Kozlov R.S. Pnevmokokki: uroki proshlogo – vzgliad v budushchee. Smolensk: MAKMAKh, 2010. [in Russian]
26. Сидоренко С.В. Тенденции в распространении антибиотикорезистентности среди возбудителей внебольничных инфекций на территории Российской Федерации. Consilium Medicum. 2007; 9 (1). / Sidorenko S.V. Tendentsii v rasprostranenii antibiotikorezistentnosti sredi vozbuditelei vnebol'nichnykh infektsii na territorii Rossiiskoi Federatsii. Consilium Medicum. 2007; 9 (1). [in Russian]
27. Козлов Р.С., Сивая О.В., Кречикова О.И. и др. Динамика резистентности Streptococcus pneumoniae к антибиотикам в России за период 1999–2009 гг. (Результаты многоцентрового проспективного исследования ПеГАС). Клин. микробиология и антимикробная химиотерапия. 2010; 12 (4): 329–41. / Kozlov R.S., Sivaia O.V., Krechikova O.I. i dr. Dinamika rezistentnosti Streptococcus pneumoniae k antibiotikam v Rossii za period 1999–2009 gg. (Rezul'taty mnogotsentrovogo prospektivnogo issledovaniia PeGAS). Klin. mikrobiologiia i antimikrobnaia khimioterapiia. 2010; 12 (4): 329–41. [in Russian]
28. Stone JW, Linong G, Andrews JM et al. Cefixime, invitro activity, pharmacokinetics and tissue penetration. J Antimicrob Chemother 1989; 23: 221–8.
29. Гучев И.А., Рафальский В.В., Мелехина Е.В. Роль цефиксима в терапии обострения хронической обструктивной болезни легких. Клин. микробиология и антимикробная химиотерапия. 2008; 10 (3): 271–89. / Guchev I.A., Rafal'skii V.V., Melekhina E.V. Rol' tsefiksima v terapii obostreniia khronicheskoi obstruktivnoi bolezni legkikh. Klin. mikrobiologiia i antimikrobnaia khimioterapiia. 2008; 10 (3): 271–89. [in Russian]
30. Endre L. Cefixime in the Treatment of Respiratory and Urinary Tract Infections. Chemotherapy 1998; 44: 31–4.
31. Dongre N, Ghai H, Kulkarni S et al. Mumbai 400022 Study of efficacy and tolerability of cefixime in sinusitis. Indian Practitioner 2002; 55 (2): 87–91.
32. Leibovitz E, Jacobs MR, Dagan R. Haemophilus influenzae: A significant Pathogen in Acute Otitis Media. Pediatr Infect Dis J 2004; 23 (12): 1142–52.
33. Dabernat H, Geslin P, Megraud F et al. Effects of cefixime or co-amoxiclav treatment on nasopharyngeal carriage of Streptococcus pneumoniae and Haemophilus influenzae in children with acute otitis media. Antimicrob Chemother J 1998; 41 (2): 253–8.
34. Leggett NJ, Caravaggio C, Rybak MJ. Cefixime. DICP Ann Pharmacother 1990; 24: 489–95. [PubMed]
35. Johnson CE, Carlin SA, Super DM et al. Cefixime compared with amoxicillin for treatment of acute otitis media. J Pediatr 1991; 119: 117–22. [PubMed]
36. Howie VM, Owen MJ. Bacteriologic and clinical efficacy of cefixime compared with amoxicillin in acute otitis media. Pediatr Infect Dis J 1987; 6: 989–91. [PubMed]
37. Rodriguez WJ, Khan W, Sait T et al. Cefixime vs cefaclor in the treatment of acute otitis media in children: a randomized, comparative study. Pediatr Infect Dis
J 1993; 12: 70–4. [PubMed]
38. Bluestone CD. Review of cefixime in the treatment of otitis media in infants and children. Pediatr Infect Dis J 1993; 12: 75–82. [PubMed]
39. McIsaac WJ, Kellner JD, Aufricht P et al. Empirical validation of guidelines for the management of pharyngitis in children and adults. JAMA 2004; 291: 1587–95.
40. Страчунский Л.С., Козлов С.Н. Современная антимикробная химиотерапия. Руководство для врачей. М.: Боргес, 2002. / Strachunskii L.S., Kozlov S.N. Sovremennaia antimikrobnaia khimioterapiia. Rukovodstvo dlia vrachei. M.: Borges, 2002. [in Russian]
41. Brook I, Foote PA. Efficacy of penicillin versus cefdinir in eradication of group A streptococci and tonsillar flora. Antimicrob Agents Chemother 2005; 49 (11): 4787–8.
42. Casey JR, Pichichero ME. Meta-analysis of cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis in children. Pediatrics 2004; 113 (4): 866–82.
43. Altamimi S, Khalil A, Khalaiwi KA et al. Short versus standard duration antibiotic therapy for acute streptococcal pharyngitis in children. Cochrane Database Syst Rev 2009; 21 (1): CD004872.
44. Adam D, Hostalek U, Tröster K. 5-day therapy of bacterial pharyngitis and tonsillitis with cefixime. Comparison with 10 day treatment with penicillin V. Klin Padiatr 1996; 208 (5): 310–3.
45. Геппе Н.А., Дронов И.А., Малявина У.С., Афонина Е.Ю. Применение цефиксима для эмпирической терапии внебольничных инфекций дыхательных путей у детей. Педиатрия. 2010; 6: 108–13. / Geppe N.A., Dronov I.A., Maliavina U.S., Afonina E.Iu. Primenenie tsefiksima dlia empiricheskoi terapii vnebol'nichnykh infektsii dykhatel'nykh putei u detei. Pediatriia. 2010; 6: 108–13. [in Russian]
46. Ludwig E, Thege MK, Arr M et al. Resistance of some selected pathogens to antimicrobials in Hungary. Int J Antimicrob Agents 1995; 6 (2): 99–102.
________________________________________________
2. Kamanin E.I., Stetsiuk O.U. Infektsii verkhnikh dykhatel'nykh putei i LOR-organov. Prakticheskoe rukovodstvo po antiinfektsionnoi khimioterapii. Pod red. L.S.Strachunskogo, Iu.B.Belousova, S.N.Kozlova. Smolensk: MAKMAKh, 2007; s. 248–58. [in Russian]
3. Sereda E.V., Katosova L.K., Volkov I.K. Effektivnost' tsefalosporina III pokoleniia tsefiksima (supraksa) pri zabolevaniiakh organov dykhaniia u detei. Lechashchii vrach. 2004; 1: 30–4. [in Russian]
4. Beloborodova N.V. K voprosu ob in"ektsiiakh antibiotikov v praktike uchastkovogo pediatra. Detskii doktor. 1999; 4: 18–21. [in Russian]
5. Ushkalova E.A. Azitromitsin pri infektsiiakh verkhnikh dykhatel'nykh putei i LOR-organov. Farmateka. 2006; 16: 37–44. [in Russian]
6. Suvorova M.P., Iakovlev S.V. Sovremennoe znachenie peroral'nykh tsefalosporinov. Consillium Medicum. 2002; 4 (4): 358–61. [in Russian]
7. Gurov A.V. Supraks v lechenii ostroi gnoinoi patologii LOR-organov. RMZh. 2007; 15 (18): 1343–6. [in Russian]
8. Nosulia E.V., Kim I.A. Ostryi rinosinusit v ambulatornoi praktike. Sonsilium Medicum. 2005; 7 (4): 300–5. [in Russian]
9. Karpishchenko S.A., Kolesnikova O.M. Ostroe vospalenie nebnykh mindalin: prichiny i vozmozhnosti lecheniia. Сonsilium Medicum. Pediatrics (Suppl.). 2014; 4: 28–30. [in Russian]
10. Geppe N.A., Dronov I.A., Maliavina U.S., Afonina E.Iu. Primenenie tsefiksima dlia empiricheskoi terapii vnebol'nichnykh infektsii dykhatel'nykh putei u detei. Pediatriia. 2010; 89: 108–13. [in Russian]
11. Harrison CJ, Chartrand SA, Pichichero ME. Microbiologic and clinical aspects of a trial of once daily cefixime compared with twice daily cefaclor for treatment of acute otitis media in infants and children. Pediatr Infect Dis J 1993; 12: 62–9.
12. Gooch WM 3rd, Philips A, Rhoades R et al. Comparison of the efficacy, safety and acceptability of cefixime and amoxicillin/clavulanate in acute otitis media. Pediatr Infect Dis J 1997; 16 (2 Suppl.): 21–4.
13. Belov B.S. Tsefiksim v terapii bakterial'nykh infektsii. RMZh. 2013 (3). [in Russian]
14. Paniakina M.A., Ovchinnikov A.Iu., Miroshnichenko N.A. O tselesoobraznosti primeneniia tsefiksima dlia lecheniia bol'nykh ostrym bakterial'nym rinosinusitom. Farmateka. 2013; 4. [in Russian]
15. Fokin A.A. Rol' tsefalosporinov v terapii vnebol'nichnykh infektsii nizhnikh i verkhnikh otdelov dykhatel'nykh putei (na osnove dannykh po chuvstvitel'nosti vozbuditelei v Rossii). Klin. mikrobiologiia i antimikrobnaia khimioterapiia. 2010; 12 (2): 146–53. [in Russian]
16. Hakim HE, Malik AC, Aronyk K et al. The prevalence of intracranial complications in pediatric frontal sinusitis. Int J Pediatr Otorhinolaryngol 2006; 70 (8): 1383–7.
17. Chow AW, Benninger MS, Brook I et al. Infectious Diseases Society of America. IDSA clinical practice guideline for acute bacterial rhinosinusitis in children and adults. Clin Infect Dis 2012; 54 (8): e72–e112.
18. Brooks I, Gooch WM 3rd, Jenkins SG et al. Medical management of acute bacterial sinusitis. Recommendations of a clinical advisory committee on pediatric and adult sinusitis. Ann Otol Rhinol Laryngol Suppl 2000; 182: 2–20.
19. EAACI Position Paper on Rhinosinusitis and Nasal Polyps Executive Summary. Allergy 2005; 60: 583–601.
20. Dongre N, Ghai H, Kulkarni S et al. Study of efficacy and tolerability of cefixime in sinusitis. Indian Practitioner 2002; 55 (2): 87–91.
21. Verhoef J, Gillissen A. Resistant Haemophilus influenzae in community-acquired respiratory tract infections: a role for cefixime. Int J Antimicrob Agents 2003; 21: 501–9.
22. McCormickс DP. Nonsevere Acute Otitis Media: A Clinical Trial Comparing Outcomes of Watchful Waiting Versus Immediate Antibiotic Treatment. Pediatrics 2005; 115: 1455–65.
23. McEwen LN, Farjo R, Foxman B. Antibiotic prescribing for otitis media: how well does it match published guidelines? Pharmacoepidemiol Drug Safety 2003; 12: 213–9.
24. American Academy of Pediatrics and American Academy of Family Physicians. Subcommittee on management of acute otitis media: clinical practice quideline: diagnosis and management of acute otitis media. Pediatrics 2004; 113: 1451–65.
25. Kozlov R.S. Pnevmokokki: uroki proshlogo – vzgliad v budushchee. Smolensk: MAKMAKh, 2010. [in Russian]
26. Sidorenko S.V. Tendentsii v rasprostranenii antibiotikorezistentnosti sredi vozbuditelei vnebol'nichnykh infektsii na territorii Rossiiskoi Federatsii. Consilium Medicum. 2007; 9 (1). [in Russian]
27. Kozlov R.S., Sivaia O.V., Krechikova O.I. i dr. Dinamika rezistentnosti Streptococcus pneumoniae k antibiotikam v Rossii za period 1999–2009 gg. (Rezul'taty mnogotsentrovogo prospektivnogo issledovaniia PeGAS). Klin. mikrobiologiia i antimikrobnaia khimioterapiia. 2010; 12 (4): 329–41. [in Russian]
28. Stone JW, Linong G, Andrews JM et al. Cefixime, invitro activity, pharmacokinetics and tissue penetration. J Antimicrob Chemother 1989; 23: 221–8.
29. Guchev I.A., Rafal'skii V.V., Melekhina E.V. Rol' tsefiksima v terapii obostreniia khronicheskoi obstruktivnoi bolezni legkikh. Klin. mikrobiologiia i antimikrobnaia khimioterapiia. 2008; 10 (3): 271–89. [in Russian]
30. Endre L. Cefixime in the Treatment of Respiratory and Urinary Tract Infections. Chemotherapy 1998; 44: 31–4.
31. Dongre N, Ghai H, Kulkarni S et al. Mumbai 400022 Study of efficacy and tolerability of cefixime in sinusitis. Indian Practitioner 2002; 55 (2): 87–91.
32. Leibovitz E, Jacobs MR, Dagan R. Haemophilus influenzae: A significant Pathogen in Acute Otitis Media. Pediatr Infect Dis J 2004; 23 (12): 1142–52.
33. Dabernat H, Geslin P, Megraud F et al. Effects of cefixime or co-amoxiclav treatment on nasopharyngeal carriage of Streptococcus pneumoniae and Haemophilus influenzae in children with acute otitis media. Antimicrob Chemother J 1998; 41 (2): 253–8.
34. Leggett NJ, Caravaggio C, Rybak MJ. Cefixime. DICP Ann Pharmacother 1990; 24: 489–95. [PubMed]
35. Johnson CE, Carlin SA, Super DM et al. Cefixime compared with amoxicillin for treatment of acute otitis media. J Pediatr 1991; 119: 117–22. [PubMed]
36. Howie VM, Owen MJ. Bacteriologic and clinical efficacy of cefixime compared with amoxicillin in acute otitis media. Pediatr Infect Dis J 1987; 6: 989–91. [PubMed]
37. Rodriguez WJ, Khan W, Sait T et al. Cefixime vs cefaclor in the treatment of acute otitis media in children: a randomized, comparative study. Pediatr Infect Dis
J 1993; 12: 70–4. [PubMed]
38. Bluestone CD. Review of cefixime in the treatment of otitis media in infants and children. Pediatr Infect Dis J 1993; 12: 75–82. [PubMed]
39. McIsaac WJ, Kellner JD, Aufricht P et al. Empirical validation of guidelines for the management of pharyngitis in children and adults. JAMA 2004; 291: 1587–95.
40. Strachunskii L.S., Kozlov S.N. Sovremennaia antimikrobnaia khimioterapiia. Rukovodstvo dlia vrachei. M.: Borges, 2002. [in Russian]
41. Brook I, Foote PA. Efficacy of penicillin versus cefdinir in eradication of group A streptococci and tonsillar flora. Antimicrob Agents Chemother 2005; 49 (11): 4787–8.
42. Casey JR, Pichichero ME. Meta-analysis of cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis in children. Pediatrics 2004; 113 (4): 866–82.
43. Altamimi S, Khalil A, Khalaiwi KA et al. Short versus standard duration antibiotic therapy for acute streptococcal pharyngitis in children. Cochrane Database Syst Rev 2009; 21 (1): CD004872.
44. Adam D, Hostalek U, Tröster K. 5-day therapy of bacterial pharyngitis and tonsillitis with cefixime. Comparison with 10 day treatment with penicillin V. Klin Padiatr 1996; 208 (5): 310–3.
45. Geppe N.A., Dronov I.A., Maliavina U.S., Afonina E.Iu. Primenenie tsefiksima dlia empiricheskoi terapii vnebol'nichnykh infektsii dykhatel'nykh putei u detei. Pediatriia. 2010; 6: 108–13. [in Russian]
46. Ludwig E, Thege MK, Arr M et al. Resistance of some selected pathogens to antimicrobials in Hungary. Int J Antimicrob Agents 1995; 6 (2): 99–102.
Авторы
О.А.Егорова*
1 ГБОУ ВПО Смоленский государственный медицинский университет Минздрава России. 214019, Россия, Смоленск, ул. Крупской, д. 28;
2 ОГБУЗ Смоленская областная клиническая больница. 214018, Россия, Смоленск, пр-т. Гагарина, д. 27
*ola-egorova@yandex.ru
1 Smolensk State Medical University of the Ministry of Health of the Russian Federation. 214019, Russian Federation, Smolensk, ul. Krupskoi, d. 28;
2 Smolensk Regional Clinical Hospital. 214018, Russian Federation, Smolensk, pr-t Gagarina, d. 27
*ola-egorova@yandex.ru
1 ГБОУ ВПО Смоленский государственный медицинский университет Минздрава России. 214019, Россия, Смоленск, ул. Крупской, д. 28;
2 ОГБУЗ Смоленская областная клиническая больница. 214018, Россия, Смоленск, пр-т. Гагарина, д. 27
*ola-egorova@yandex.ru
________________________________________________
1 Smolensk State Medical University of the Ministry of Health of the Russian Federation. 214019, Russian Federation, Smolensk, ul. Krupskoi, d. 28;
2 Smolensk Regional Clinical Hospital. 214018, Russian Federation, Smolensk, pr-t Gagarina, d. 27
*ola-egorova@yandex.ru
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