1. Junker AK, Thomas EE, Radcliffe A et al. Epstein-Barr virus shedding in breast milk. Am J Med Sci 1991; 302: 220.
2. Higgins CD, Swerdlow AJ, Macsween KF et al. A study of risk factors for acquisition of Epstein-Barr virus and its subtypes. J Infect Dis 2007; 195: 474.
3. Figueira-Silva CM, Pereira FE. Prevalence of Epstein-Barr virus antibodies in healthy children and adolescents in Vitória, State of Espírito Santo, Brazil. Rev Soc Bras Med Trop 2004; 37 (5): 409–12.
4. Zerr DM, Meier AS, Selke SS et al. A population-based study of primary human herpesvirus 6 infection. N Engl J Med 2005; 352: 768.
5. Balfour HH Jr, Odumade OA, Schmeling DO et al. Behavioral, virologic, and immunologic factors associated with acquisition and severity of primary Epstein-Barr virus infection in university students. J Infect Dis 2013; 207: 80.
6. Grotto L et al. Clinical and laboratory presentation of EBV positive infectious mononucieosis in young adults. Epidemiol Infect 2003; 131: 683–9.
7. Соколова Е.Д., Никольский М.А., Муратова В.А. и др. Инфекционный мононуклеоз, вызванный g-герпесвирусом человека, и его лабораторная диагностика у детей. Сб. науч. тр. ДГКБ №5 им. Н.Ф.Филатова «Современные технологии лечения детей и подростков». Вып. 3. СПб., 2014; с. 98–103. / Sokolova E.D., Nikol'skii M.A., Muratova V.A. i dr. Infektsionnyi mononukleoz, vyzvannyi g-gerpesvirusom cheloveka, i ego laboratornaia diagnostika u detei. Sb. nauch. tr. DGKB №5 im. N.F.Filatova «Sovremennye tekhnologii lecheniia detei i podrostkov». Vyp. 3. SPb., 2014; s. 98–103. [in Russian]
8. Brigden ML, Au S, Thompson S et al. Infectious mononucleosis in an outpatient population: diagnostic utility of 2 automated hematology analyzers and the sensitivity and specificity of Hoagland's criteria in heterophile-positive patients. Arch Pathol Lab Med 1999; 123: 875.
9. Horwitz CA, Henle W, Henle G et al. Clinical and laboratory evaluation of infants and children with Epstein-Barr virus-induced infectious mononucleosis: report of 32 patients (aged 10–48 months). Blood 1981; 57: 933–8.
10. Bruu AL, Hjetland R, Holter E et al. Evaluation of 12 commercial tests for detection of Epstein-Barr virus-specific and heterophile antibodies. Clin Diagn Lab Immunol 2000; 7: 451.
11. Guerrero-Ramos A, Patel M, Kadakia K et al. Performance of the architect EBV antibody panel for determination of Epstein-Barr virus infection stage in immunocompetent adolescents and young adults with clinical suspicion of infectious mononucleosis. Clin Vaccine Immunol 2014; 21: 817–23.
12. Hess RD. Routine Epstein–Barr virus diagnostics from the laboratory perspective: still challenging after 35 years. J Clin Microbiol 2004; 42: 3381–7.
13. Crowley A, Connell J, Schaffer K et al. Is there diagnostic value in detection of immunoglobulin g antibodies to the epstein-barr virus early antigen? Biores Open Access 2012; 1 (6): 291–6. doi: 10.1089/biores.2012.0274.
14. Al Tabaa Y, Tuaillon E, Bollore K. Functional Epstein-Barr virus reservoir in plasma cells derived from infected peripheral blood memory B cells. Blood 2009; 113 (3): 604–11; doi: 10.1182/blood-2008-02-136903. Epub 2008.
15. Лаврентьева И.Н., Финогенова Н.А., Мамедова Е.А. Особенности диагностики и течения герпетических инфекций, вызванных вирусами Эпштей̆на–Барр и герпеса человека 6 типа при нейтропениях у детей раннего возраста. Детские инфекции. 2011; 3: 11–5. / Lavrent'eva I.N., Finogenova N.A., Mamedova E.A. Osobennosti diagnostiki i techeniia gerpeticheskikh infektsiĭ, vyzvannykh virusami Epshteĭna–Barr i gerpesa cheloveka 6 tipa pri neĭtropeniiakh u deteĭ rannego vozrasta. Detskie infektsii. 2011; 3: 11–5. [in Russian]
16. Боковой А.Г. Герпесвирусные инфекции у детей – актуальная проблема современной клинической практики. Детские инфекции. 2010; 2: 3–7. / Bokovoĭ A.G. Gerpesvirusnye infektsii u deteĭ – aktual'naia problema sovremennoĭ klinicheskoĭ praktiki. Detskie infektsii. 2010; 2: 3–7. [in Russian]
17. Михайлова Т.А., Бусарова И.А., Пахалкова Е.В., Утянская И.Г. Инфекционный мононуклеоз у детей – болезнь или синдром. Совр. наукоемкие технологии. 2007; 10: 52. / Mikhailova T.A., Busarova I.A., Pakhalkova E.V., Utianskaia I.G. Infektsionnyi mononukleoz u detei – bolezn' ili sindrom. Sovr. naukoemkie tekhnologii. 2007; 10: 52. [in Russian]
18. Белан Ю.Б., Михайлова Ю.Б. Современные аспекты диагностики инфекционного мононуклеоза у детей. Педиатр. 2010; 1 (2): 19–25. / Belan Iu.B., Mikhailova Iu.B. Sovremennye aspekty diagnostiki infektsionnogo mononukleoza u detei. Pediatr. 2010; 1 (2): 19–25. [in Russian]
19. Баранов А.Е., Ровенская Л.В., Шевцова С.Ю. Клинические проявления инфекционного мононуклеоза. По материалам ОГУЗ «Инфекционная клиническая больница им. Е.Н.Павловского» Белгорода. / Baranov A.E., Rovenskaia L.V., Shevtsova S.Iu. Klinicheskie proiavleniia infektsionnogo mononukleoza. Po materialam OGUZ «Infektsionnaia klinicheskaia bol'nitsa im. E.N.Pavlovskogo» Belgoroda. [in Russian]
20. Бурмагина И.А., Поздеева М.А., Агафонов В.М. Инфекционный мононуклеоз в северном регионе. Совр. медицина: актуальные вопр. 2014; 33: 26–31. / Burmagina I.A., Pozdeeva M.A., Agafonov V.M. Infektsionnyi mononukleoz v severnom regione. Sovr. meditsina: aktual'nye vopr. 2014; 33: 26–31. [in Russian]
21. Егорова Н.Ю., Гусева Л.Н., Гусева Н.А. и др. Инфекционный мононуклеоз у детей: диагностика, лечение и наблюдение в катамнезе. Consilium Medicum. Педиатрия (Прил.). 2010; 4. / Egorova N.Iu., Guseva L.N., Guseva N.A. i dr. Infektsionnyi mononukleoz u detei: diagnostika, lechenie i nabliudenie v katamneze. Consilium Medicum. Pediatrics (Suppl.). 2010; 4. [in Russian]
22. Шарипова Е.В. Клинико-лабораторная характеристика и возрастные особенности инфекционного мононуклеоза у детей. Автореф. дис. … канд. мед. наук. СПбГПМА. Санкт-Петербург, 2012. / Sharipova E.V. Kliniko-laboratornaia kharakteristika i vozrastnye osobennosti infektsionnogo mononukleoza u detei. Avtoref. dis. … kand. med. nauk. SPbGPMA. Sankt-Peterburg, 2012. [in Russian]
23. Long, Sarah S, MD. Principles and Practice of Pediatric Infectious Diseases, Fourth Edition, 2012. Elsevier.
24. Wreghitt TG, Teare EL, Sule O et al. Cytomegalovirus infection in immunocompetent patients. Clin Infect Dis 2003; 37: 1603–6.
25. Bravender T. Epstein-Barr virus, cytomegalovirus, and infectious mononucleosis. Adolesc Med State Art Rev 2010; 21 (2): 251–64.
26. Новосад Е.В. Инфекционный мононуклеоз, ассоциированный с вирусом герпеса 6 типа. Автореф. дис. … канд. мед. наук. М., 2010. / Novosad E.V. Infektsionnyi mononukleoz, assotsiirovannyi s virusom gerpesa 6 tipa. Avtoref. dis. … kand. med. nauk. M., 2010. [in Russian]
27. Михайлова Т.А. Совершенствование дифференциальной диагностики инфекционного мононуклеоза герпесвирусной этиологии у детей. Автореф. дис. … канд. мед. наук. Тюмень, 2008; с. 890. / Mikhailova T.A. Sovershenstvovanie differentsial'noi diagnostiki infektsionnogo mononukleoza gerpesvirusnoi etiologii u detei. Avtoref. dis. … kand. med. nauk. Tiumen', 2008; s. 890. [in Russian]
28. Касымова Е.Б., Башкина О.А., Галимзянов Х.М. Инфекционный̆ мононуклеоз у детей̆, ассоциированный с вирусами герпеса 4-го и 5-го типов. Инфекционные болезни. 2012; 10 (3): 44–7. / Kasymova E.B., Bashkina O.A., Galimzianov Kh.M. Infektsionnyĭ mononukleoz u deteĭ, assotsiirovannyĭ s virusami gerpesa 4-go i 5-go tipov. Infektsionnye bolezni. 2012; 10 (3): 44–7. [in Russian]
29. Егорова Н.Ю. Цитомегаловирусный мононуклеоз (клиника, диагностика, дифференциальный диагноз). Автореф. … канд. мед. наук. М., 2006. / Egorova N.Iu. Tsitomegalovirusnyi mononukleoz (klinika, diagnostika, differentsial'nyi diagnoz). Avtoref. … kand. med. nauk. M., 2006. [in Russian]
30. Mandell, Douglas and Bennett's. Principles and Practice of Infectious Diseases Eighth Edition. Elsevier 2015; p. 1738–53.
31. Мартынова Г.П., Богвилене Я.А., Искра И.П. и др. Клинико-лабораторная характеристика инфекционного мононуклеоза у детей. Лечение и профилактика. 2015; 4: 29–35. / Martynova G.P., Bogvilene Ia.A., Iskra I.P. i dr. Kliniko-laboratornaia kharakteristika infektsionnogo mononukleoza u detei. Lechenie i profilaktika. 2015; 4: 29–35. [in Russian]
32. Olson D, Huntington MK. Co-infection with cytomegalovirus and Epstein-Barr virus in mononucleosis: case report and review of literature. S D Med 2009; 62 (9): 349, 351–3. Review.
33. Ito Y, Shibata-Watanabe Y, Kawada J et al. Cytomegalovirus and Epstein-Barr virus coinfection in three toddlers with prolonged illnesses. J Med Virol 2009; 81 (8): 1399–402; doi: 10.1002/jmv.21527.
34. Xia Wang et al. Coinfection with EBV/CMV and other respiratory agents in children with suspected infectious mononucleosis. Virol J 2010; 7: 247–57.
35. Park JM, Shin JI, Lee JS et al. False positive immunoglobulin m antibody to cytomegalovirus in child with infectious mononucleosis caused by epstein-barr virus infection. Yonsei Med J 2009; 50 (5): 713–6; doi: 10.3349/ymj.2009.50.5.713. Epub 2009.
36. Miendje Deyi Y, Goubau P, Bodéus M. False-positive IgM antibody tests for cytomegalovirus in patients with acute Epstein-Barr virus infection. Eur J Clin Microbiol Infect Dis 2000; 19 (7): 557–60.
37. Wreghitt TG, Teare EL, Sule O et al. Cytomegalovirus infection in immunocompetent patients. Clin Infect Dis 2003; 37: 1603–6.
38. Смирнова А.И., Россихина Е.В., Колеватых Е.П. Лабораторная диагностика цитомегаловирусной инфекции. Вятский мед. вестн. 2010; 3: 45–50. / Smirnova A.I., Rossikhina E.V., Kolevatykh E.P. Laboratornaia diagnostika tsitomegalovirusnoi infektsii. Viatskii med. vestn. 2010; 3: 45–50. [in Russian]
39. Притулина Ю.Г., Саломахин Г.Г., Пегусов С.М. Особенности течения атипичных форм инфекционного мононуклеоза. Актуальные направления научных исследований XXI века: теория и практика. 2014. Т. 2. Вып. 3; с. 81–5. / Pritulina Iu.G., Salomakhin G.G., Pegusov S.M. Osobennosti techeniia atipichnykh form infektsionnogo mononukleoza. Aktual'nye napravleniia nauchnykh issledovanii XXI veka: teoriia i praktika. 2014. T. 2. Vyp. 3; s. 81–5. [in Russian]

________________________________________________

1. Junker AK, Thomas EE, Radcliffe A et al. Epstein-Barr virus shedding in breast milk. Am J Med Sci 1991; 302: 220.
2. Higgins CD, Swerdlow AJ, Macsween KF et al. A study of risk factors for acquisition of Epstein-Barr virus and its subtypes. J Infect Dis 2007; 195: 474.
3. Figueira-Silva CM, Pereira FE. Prevalence of Epstein-Barr virus antibodies in healthy children and adolescents in Vitória, State of Espírito Santo, Brazil. Rev Soc Bras Med Trop 2004; 37 (5): 409–12.
4. Zerr DM, Meier AS, Selke SS et al. A population-based study of primary human herpesvirus 6 infection. N Engl J Med 2005; 352: 768.
5. Balfour HH Jr, Odumade OA, Schmeling DO et al. Behavioral, virologic, and immunologic factors associated with acquisition and severity of primary Epstein-Barr virus infection in university students. J Infect Dis 2013; 207: 80.
6. Grotto L et al. Clinical and laboratory presentation of EBV positive infectious mononucieosis in young adults. Epidemiol Infect 2003; 131: 683–9.
7. Sokolova E.D., Nikol'skii M.A., Muratova V.A. i dr. Infektsionnyi mononukleoz, vyzvannyi g-gerpesvirusom cheloveka, i ego laboratornaia diagnostika u detei. Sb. nauch. tr. DGKB №5 im. N.F.Filatova «Sovremennye tekhnologii lecheniia detei i podrostkov». Vyp. 3. SPb., 2014; s. 98–103. [in Russian]
8. Brigden ML, Au S, Thompson S et al. Infectious mononucleosis in an outpatient population: diagnostic utility of 2 automated hematology analyzers and the sensitivity and specificity of Hoagland's criteria in heterophile-positive patients. Arch Pathol Lab Med 1999; 123: 875.
9. Horwitz CA, Henle W, Henle G et al. Clinical and laboratory evaluation of infants and children with Epstein-Barr virus-induced infectious mononucleosis: report of 32 patients (aged 10–48 months). Blood 1981; 57: 933–8.
10. Bruu AL, Hjetland R, Holter E et al. Evaluation of 12 commercial tests for detection of Epstein-Barr virus-specific and heterophile antibodies. Clin Diagn Lab Immunol 2000; 7: 451.
11. Guerrero-Ramos A, Patel M, Kadakia K et al. Performance of the architect EBV antibody panel for determination of Epstein-Barr virus infection stage in immunocompetent adolescents and young adults with clinical suspicion of infectious mononucleosis. Clin Vaccine Immunol 2014; 21: 817–23.
12. Hess RD. Routine Epstein–Barr virus diagnostics from the laboratory perspective: still challenging after 35 years. J Clin Microbiol 2004; 42: 3381–7.
13. Crowley A, Connell J, Schaffer K et al. Is there diagnostic value in detection of immunoglobulin g antibodies to the epstein-barr virus early antigen? Biores Open Access 2012; 1 (6): 291–6. doi: 10.1089/biores.2012.0274.
14. Al Tabaa Y, Tuaillon E, Bollore K. Functional Epstein-Barr virus reservoir in plasma cells derived from infected peripheral blood memory B cells. Blood 2009; 113 (3): 604–11; doi: 10.1182/blood-2008-02-136903. Epub 2008.
15. Lavrent'eva I.N., Finogenova N.A., Mamedova E.A. Osobennosti diagnostiki i techeniia gerpeticheskikh infektsiĭ, vyzvannykh virusami Epshteĭna–Barr i gerpesa cheloveka 6 tipa pri neĭtropeniiakh u deteĭ rannego vozrasta. Detskie infektsii. 2011; 3: 11–5. [in Russian]
16. Bokovoĭ A.G. Gerpesvirusnye infektsii u deteĭ – aktual'naia problema sovremennoĭ klinicheskoĭ praktiki. Detskie infektsii. 2010; 2: 3–7. [in Russian]
17. Mikhailova T.A., Busarova I.A., Pakhalkova E.V., Utianskaia I.G. Infektsionnyi mononukleoz u detei – bolezn' ili sindrom. Sovr. naukoemkie tekhnologii. 2007; 10: 52. [in Russian]
18. Belan Iu.B., Mikhailova Iu.B. Sovremennye aspekty diagnostiki infektsionnogo mononukleoza u detei. Pediatr. 2010; 1 (2): 19–25. [in Russian]
19. Baranov A.E., Rovenskaia L.V., Shevtsova S.Iu. Klinicheskie proiavleniia infektsionnogo mononukleoza. Po materialam OGUZ «Infektsionnaia klinicheskaia bol'nitsa im. E.N.Pavlovskogo» Belgoroda. [in Russian]
20. Burmagina I.A., Pozdeeva M.A., Agafonov V.M. Infektsionnyi mononukleoz v severnom regione. Sovr. meditsina: aktual'nye vopr. 2014; 33: 26–31. [in Russian]
21. Egorova N.Iu., Guseva L.N., Guseva N.A. i dr. Infektsionnyi mononukleoz u detei: diagnostika, lechenie i nabliudenie v katamneze. Consilium Medicum. Pediatrics (Suppl.). 2010; 4. [in Russian]
22. Sharipova E.V. Kliniko-laboratornaia kharakteristika i vozrastnye osobennosti infektsionnogo mononukleoza u detei. Avtoref. dis. … kand. med. nauk. SPbGPMA. Sankt-Peterburg, 2012. [in Russian]
23. Long, Sarah S, MD. Principles and Practice of Pediatric Infectious Diseases, Fourth Edition, 2012. Elsevier.
24. Wreghitt TG, Teare EL, Sule O et al. Cytomegalovirus infection in immunocompetent patients. Clin Infect Dis 2003; 37: 1603–6.
25. Bravender T. Epstein-Barr virus, cytomegalovirus, and infectious mononucleosis. Adolesc Med State Art Rev 2010; 21 (2): 251–64.
26. Novosad E.V. Infektsionnyi mononukleoz, assotsiirovannyi s virusom gerpesa 6 tipa. Avtoref. dis. … kand. med. nauk. M., 2010. [in Russian]
27. Mikhailova T.A. Sovershenstvovanie differentsial'noi diagnostiki infektsionnogo mononukleoza gerpesvirusnoi etiologii u detei. Avtoref. dis. … kand. med. nauk. Tiumen', 2008; s. 890. [in Russian]
28. Kasymova E.B., Bashkina O.A., Galimzianov Kh.M. Infektsionnyĭ mononukleoz u deteĭ, assotsiirovannyĭ s virusami gerpesa 4-go i 5-go tipov. Infektsionnye bolezni. 2012; 10 (3): 44–7. [in Russian]
29. Egorova N.Iu. Tsitomegalovirusnyi mononukleoz (klinika, diagnostika, differentsial'nyi diagnoz). Avtoref. … kand. med. nauk. M., 2006. [in Russian]
30. Mandell, Douglas and Bennett's. Principles and Practice of Infectious Diseases Eighth Edition. Elsevier 2015; p. 1738–53.
31. Martynova G.P., Bogvilene Ia.A., Iskra I.P. i dr. Kliniko-laboratornaia kharakteristika infektsionnogo mononukleoza u detei. Lechenie i profilaktika. 2015; 4: 29–35. [in Russian]
32. Olson D, Huntington MK. Co-infection with cytomegalovirus and Epstein-Barr virus in mononucleosis: case report and review of literature. S D Med 2009; 62 (9): 349, 351–3. Review.
33. Ito Y, Shibata-Watanabe Y, Kawada J et al. Cytomegalovirus and Epstein-Barr virus coinfection in three toddlers with prolonged illnesses. J Med Virol 2009; 81 (8): 1399–402; doi: 10.1002/jmv.21527.
34. Xia Wang et al. Coinfection with EBV/CMV and other respiratory agents in children with suspected infectious mononucleosis. Virol J 2010; 7: 247–57.
35. Park JM, Shin JI, Lee JS et al. False positive immunoglobulin m antibody to cytomegalovirus in child with infectious mononucleosis caused by epstein-barr virus infection. Yonsei Med J 2009; 50 (5): 713–6; doi: 10.3349/ymj.2009.50.5.713. Epub 2009.
36. Miendje Deyi Y, Goubau P, Bodéus M. False-positive IgM antibody tests for cytomegalovirus in patients with acute Epstein-Barr virus infection. Eur J Clin Microbiol Infect Dis 2000; 19 (7): 557–60.
37. Wreghitt TG, Teare EL, Sule O et al. Cytomegalovirus infection in immunocompetent patients. Clin Infect Dis 2003; 37: 1603–6.
38. Smirnova A.I., Rossikhina E.V., Kolevatykh E.P. Laboratornaia diagnostika tsitomegalovirusnoi infektsii. Viatskii med. vestn. 2010; 3: 45–50. [in Russian]
39. Pritulina Iu.G., Salomakhin G.G., Pegusov S.M. Osobennosti techeniia atipichnykh form infektsionnogo mononukleoza. Aktual'nye napravleniia nauchnykh issledovanii XXI veka: teoriia i praktika. 2014. T. 2. Vyp. 3; s. 81–5. [in Russian]

М.А.Никольский*1, Е.Д.Соколова2, Д.А.Лиознов1,3

1 ГБОУ ВПО Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова Минздрава России. 197022, Россия, Санкт-Петербург, ул. Льва Толстого, д. 6/8;
2 ГБУЗ Детская городская клиническая больница №5 им. Н.Ф.Филатова. 192289, Россия, Санкт-Петербург, ул. Бухарестская, д. 134;
3 ФГБУ Северо-Западный федеральный медицинский исследовательский центр им. В.А.Алмазова Минздрава России. 197341, Россия, Санкт-Петербург, ул. Аккуратова, д. 2
*nicolm@inbox.ru

________________________________________________

M.A.Nikolskiy*1, E.D.Sokolova2, D.A.Lioznov1,3

1 I.M.Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation. 197022, Russian Federation, Saint Petersburg, ul. L'va Tolstogo, d. 6/8;
2 N.F.Filatov Children City Clinical Hospital №5. 192289, Russian Federation, Saint Petersburg, ul. Bukharestskaia, d. 134;
3 V.A.Almazov North-West federal medical research center of the Ministry of Health of the Russian Federation. 197341, Russian Federation, Saint Petersburg, ul. Akkuratova, d. 2
*nicolm@inbox.ru