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Патогенетическая терапия нарушений микробиоценоза желудочно-кишечного тракта при острых кишечных инфекциях у детей
Патогенетическая терапия нарушений микробиоценоза желудочно-кишечного тракта при острых кишечных инфекциях у детей
Плоскирева А.А. Патогенетическая терапия нарушений микробиоценоза желудочно-кишечного тракта при острых кишечных инфекциях у детей. Педиатрия (Прил. к журн. Consilium Medicum). 2017; 3: 77–80.
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Аннотация
В статье рассмотрены современные представления о патогенетических подходах к коррекции нарушений микробиоценоза при острых кишечных инфекциях с использованием метабиотиков.
Ключевые слова: острые кишечные инфекции, терапия, метабиотики.
Key words: acute intestinal infections, therapy, metabiotics.
Ключевые слова: острые кишечные инфекции, терапия, метабиотики.
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Key words: acute intestinal infections, therapy, metabiotics.
Полный текст
Список литературы
1. Инфекционная заболеваемость в Российской Федерации за январь-декабрь 2016 г. (по данным формы №1 «Сведения об инфекционных и паразитарных заболеваниях»). http://rospotrebnadzor.ru/activities/statistical-materials/statictic_details.php?ELEMENT_ID=7804. / Infektsionnaia zabolevaemost' v Rossiiskoi Federatsii za ianvar'-dekabr' 2016 g. (po dannym formy №1 «Svedeniia ob infektsionnykh i parazitarnykh zabolevaniiakh»). http://rospotrebnadzor.ru/activities/statistical-materials/statictic_details.php?ELEMENT_ID=7804. [in Russian]
2. Allen SJ, Martinez EG, Gregorio GV et al. Probiotics for treating acute infectious diarrhoea. Cochrane Database Syst Rev 2010; CD003048.
3. Martins FS, Silva AA, Vieira AT et al. Comparative study of Bifidobacterium animalis,
Escherichia coli, Lactobacillus casei and Saccharomyces boulardii probiotic properties. Arch Microbiol 2009; 191: 623–30.
4. Quigley EM. Gut microbiota and the role of probiotics in therapy. Curr Opin Pharmacol 2011; 11 (6): 593–603.
5. Sekirov I, Russell SL, Antunes LC, Finlay BB. Gut Microbiota in Health and Disease Physiol Rev 2010; 90 (3): 859–904.
6. Fons M, Gomez A, Karjalainen T. Mechanisms of colonization and colonization resistance of the digestive tract. Microbial Ecol Health Dis (Suppl.) 2000; 2: 240–6.
7. Reid G. Probiotics: definition, scope and mechanisms of action. Best Pract Res Clin Gastroenterol 2016; 30 (1): 17–25. DOI: 10.1016/j.bpg.2015.12.001
8. Shenderov BA. Metabiotics: novel idea or natural development of probiotic conception. MicrobEcol Health Dis 2013; 24: 20399. http://dx.doi.org/10.3402/mehd.v24i0.20399.
9. Урсова Н.И. Базовые функции кишечной микрофлоры и формирование микробиоценоза у детей. Тактика педиатра. 2006; 3: 30–7. / Ursova N.I. Bazovye funktsii kishechnoi mikroflory i formirovanie mikrobiotsenoza u detei. Taktika pediatra. 2006; 3: 30–7. [in Russian]
10. Laparra JM, Sanz Y. Comparison of in vitro models to study bacterial adhesion to the intestinal epithelium. Lett Appl Microbiol 2009; 49 (6): 695–701.
11. Tacket C, Sztein M, Losonsky G et al. Humoral, mucosal, and cellular immune responses to oral Norwalk virus-like particles in volunteers. Clin Immunol 2003; 108 (3): 241–7.
12. Van der Waaij D. Evidence of immunoregulation of comporetion of intestinal microflora and itspractica on seguences. Eur J Clin Microbiol 1988; 7 (1): 101–6.
13. Szajewska H, Skórka A, Ruszczyński M et al. Meta-analysis: Lactobacillus GG for treating acute gastroenteritis in children – updated analysis of randomised controlled trials. Aliment Pharmacol Ther 2013; 38: 467–76.
14. Collado MC, Meriluoto J, Salminen S. Role of commercial probiotic strains against human pathogen adhesion to intestinal mucus. Lett Appl Microbiol 2007; 45: 454–60.
15. Hutsko SL, Meizlisch K, Wick M, Lilburn MS. Early intestinal development and mucin transcription in the young poult with probiotic and mannan oligosaccharide prebiotic supplementation. Poult Sci 2016; 95 (5): 1173–8. DOI: 10.3382/ps/pew019
16. Olson JK, Rager TM, Navarro JB et al. Harvesting the benefits of biofilms: A novel probiotic delivery system for the prevention of necrotizing enterocolitis. J Pediatr Surg 2016; 51 (6): 936–41. DOI: 10.1016/j.jpedsurg.2016.02.062
17. Mulder J, Wels M, Kuipers OP et al. Unleashing natural competence in Lactococcus lactis by induction of the competence regulator ComX. Appl Environ Microbiol 2017 Aug 4. pii: AEM.01320-17. DOI: 10.1128/AEM.01320-17
18. Плоскирева А.А., Тхакушинова Н.Х., Горелов А.В. Результаты сравнительного исследования по оценке эффективности и безопасности пробиотиков в стартовой терапии острых кишечных инфекций вирусной этиологии у детей. Инфекционные болезни. 2013; 11 (1): 50–5. / Ploskireva A.A., Tkhakushinova N.Kh., Gorelov A.V. Rezul'taty sravnitel'nogo issledovaniia po otsenke effektivnosti i bezopasnosti probiotikov v startovoi terapii ostrykh kishechnykh infektsii virusnoi etiologii u detei. Infektsionnye bolezni. 2013; 11 (1): 50–5. [in Russian]
19. Szajewska H. Use of Probiotics for Management of Acute Gastroenteritis: A Position Paper by the ESPGHAN Working Group for Probiotics and Prebiotics. JPGN 2014; 55 (4): 531–9.
20. Szajewska H, Guarino A, Hojsak I et al. Use of probiotics for management of acute gastroenteritis: a position paper by the ESPGHAN Working Group for Probiotics and Prebiotics. J Pediatr Gastroenterol Nutr 2014; 58 (4): 531–9.
21. Shenderov BA. Probiotic (symbiotic) bacterial languages. Anaerobe 2011; 17 (6): 490–5.
22. Дышлюк Л.С., Кригер О.В., Милентьева И.С. и др. Введение в направление. Биотехнология: учебное пособие. Кемерово: КемТИПП, 2014. / Dyshliuk L.S., Kriger O.V., Milent'eva I.S. i dr. Vvedenie v napravlenie. Biotekhnologiia: uchebnoe posobie. Kemerovo: KemTIPP, 2014. [in Russian]
23. Ардатская М.Д. Клиническое значение короткоцепочечных жирных кислот при патологии желудочно-кишечного тракта. Дис. ... д-ра мед. наук. М.: 2003. / Ardatskaia M.D. Klinicheskoe znachenie korotkotsepochechnykh zhirnykh kislot pri patologii zheludochno-kishechnogo trakta. Dis. ... d-ra med. nauk. M.: 2003. [in Russian]
24. Коровина Н.А., Захарова И.Н., Малова Н.Е. и др. Роль пребиотиков и пробиотиков в функциональном питании детей. Лечащий врач. 2005; 2: 46–52. / Korovina N.A., Zakharova I.N., Malova N.E. i dr. Rol' prebiotikov i probiotikov v funktsional'nom pitanii detei. Lechashchii vrach. 2005; 2: 46–52. [in Russian]
25. http://www.grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=c1bb445d-bc9a-4520-a2fd- 9b17dd6ede87&t=93f52b8c-d199-4410-ac57-7bd49b8a1dbd.
2. Allen SJ, Martinez EG, Gregorio GV et al. Probiotics for treating acute infectious diarrhoea. Cochrane Database Syst Rev 2010; CD003048.
3. Martins FS, Silva AA, Vieira AT et al. Comparative study of Bifidobacterium animalis,
Escherichia coli, Lactobacillus casei and Saccharomyces boulardii probiotic properties. Arch Microbiol 2009; 191: 623–30.
4. Quigley EM. Gut microbiota and the role of probiotics in therapy. Curr Opin Pharmacol 2011; 11 (6): 593–603.
5. Sekirov I, Russell SL, Antunes LC, Finlay BB. Gut Microbiota in Health and Disease Physiol Rev 2010; 90 (3): 859–904.
6. Fons M, Gomez A, Karjalainen T. Mechanisms of colonization and colonization resistance of the digestive tract. Microbial Ecol Health Dis (Suppl.) 2000; 2: 240–6.
7. Reid G. Probiotics: definition, scope and mechanisms of action. Best Pract Res Clin Gastroenterol 2016; 30 (1): 17–25. DOI: 10.1016/j.bpg.2015.12.001
8. Shenderov BA. Metabiotics: novel idea or natural development of probiotic conception. MicrobEcol Health Dis 2013; 24: 20399. http://dx.doi.org/10.3402/mehd.v24i0.20399.
9. Ursova N.I. Bazovye funktsii kishechnoi mikroflory i formirovanie mikrobiotsenoza u detei. Taktika pediatra. 2006; 3: 30–7. [in Russian]
10. Laparra JM, Sanz Y. Comparison of in vitro models to study bacterial adhesion to the intestinal epithelium. Lett Appl Microbiol 2009; 49 (6): 695–701.
11. Tacket C, Sztein M, Losonsky G et al. Humoral, mucosal, and cellular immune responses to oral Norwalk virus-like particles in volunteers. Clin Immunol 2003; 108 (3): 241–7.
12. Van der Waaij D. Evidence of immunoregulation of comporetion of intestinal microflora and itspractica on seguences. Eur J Clin Microbiol 1988; 7 (1): 101–6.
13. Szajewska H, Skórka A, Ruszczyński M et al. Meta-analysis: Lactobacillus GG for treating acute gastroenteritis in children – updated analysis of randomised controlled trials. Aliment Pharmacol Ther 2013; 38: 467–76.
14. Collado MC, Meriluoto J, Salminen S. Role of commercial probiotic strains against human pathogen adhesion to intestinal mucus. Lett Appl Microbiol 2007; 45: 454–60.
15. Hutsko SL, Meizlisch K, Wick M, Lilburn MS. Early intestinal development and mucin transcription in the young poult with probiotic and mannan oligosaccharide prebiotic supplementation. Poult Sci 2016; 95 (5): 1173–8. DOI: 10.3382/ps/pew019
16. Olson JK, Rager TM, Navarro JB et al. Harvesting the benefits of biofilms: A novel probiotic delivery system for the prevention of necrotizing enterocolitis. J Pediatr Surg 2016; 51 (6): 936–41. DOI: 10.1016/j.jpedsurg.2016.02.062
17. Mulder J, Wels M, Kuipers OP et al. Unleashing natural competence in Lactococcus lactis by induction of the competence regulator ComX. Appl Environ Microbiol 2017 Aug 4. pii: AEM.01320-17. DOI: 10.1128/AEM.01320-17
18. Ploskireva A.A., Tkhakushinova N.Kh., Gorelov A.V. Rezul'taty sravnitel'nogo issledovaniia po otsenke effektivnosti i bezopasnosti probiotikov v startovoi terapii ostrykh kishechnykh infektsii virusnoi etiologii u detei. Infektsionnye bolezni. 2013; 11 (1): 50–5. [in Russian]
19. Szajewska H. Use of Probiotics for Management of Acute Gastroenteritis: A Position Paper by the ESPGHAN Working Group for Probiotics and Prebiotics. JPGN 2014; 55 (4): 531–9.
20. Szajewska H, Guarino A, Hojsak I et al. Use of probiotics for management of acute gastroenteritis: a position paper by the ESPGHAN Working Group for Probiotics and Prebiotics. J Pediatr Gastroenterol Nutr 2014; 58 (4): 531–9.
21. Shenderov BA. Probiotic (symbiotic) bacterial languages. Anaerobe 2011; 17 (6): 490–5.
22. Dyshliuk L.S., Kriger O.V., Milent'eva I.S. i dr. Vvedenie v napravlenie. Biotekhnologiia: uchebnoe posobie. Kemerovo: KemTIPP, 2014. [in Russian]
23. Ardatskaia M.D. Klinicheskoe znachenie korotkotsepochechnykh zhirnykh kislot pri patologii zheludochno-kishechnogo trakta. Dis. ... d-ra med. nauk. M.: 2003. [in Russian]
24. Korovina N.A., Zakharova I.N., Malova N.E. i dr. Rol' prebiotikov i probiotikov v funktsional'nom pitanii detei. Lechashchii vrach. 2005; 2: 46–52. [in Russian]
25. http://www.grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=c1bb445d-bc9a-4520-a2fd- 9b17dd6ede87&t=93f52b8c-d199-4410-ac57-7bd49b8a1dbd.
2. Allen SJ, Martinez EG, Gregorio GV et al. Probiotics for treating acute infectious diarrhoea. Cochrane Database Syst Rev 2010; CD003048.
3. Martins FS, Silva AA, Vieira AT et al. Comparative study of Bifidobacterium animalis,
Escherichia coli, Lactobacillus casei and Saccharomyces boulardii probiotic properties. Arch Microbiol 2009; 191: 623–30.
4. Quigley EM. Gut microbiota and the role of probiotics in therapy. Curr Opin Pharmacol 2011; 11 (6): 593–603.
5. Sekirov I, Russell SL, Antunes LC, Finlay BB. Gut Microbiota in Health and Disease Physiol Rev 2010; 90 (3): 859–904.
6. Fons M, Gomez A, Karjalainen T. Mechanisms of colonization and colonization resistance of the digestive tract. Microbial Ecol Health Dis (Suppl.) 2000; 2: 240–6.
7. Reid G. Probiotics: definition, scope and mechanisms of action. Best Pract Res Clin Gastroenterol 2016; 30 (1): 17–25. DOI: 10.1016/j.bpg.2015.12.001
8. Shenderov BA. Metabiotics: novel idea or natural development of probiotic conception. MicrobEcol Health Dis 2013; 24: 20399. http://dx.doi.org/10.3402/mehd.v24i0.20399.
9. Урсова Н.И. Базовые функции кишечной микрофлоры и формирование микробиоценоза у детей. Тактика педиатра. 2006; 3: 30–7. / Ursova N.I. Bazovye funktsii kishechnoi mikroflory i formirovanie mikrobiotsenoza u detei. Taktika pediatra. 2006; 3: 30–7. [in Russian]
10. Laparra JM, Sanz Y. Comparison of in vitro models to study bacterial adhesion to the intestinal epithelium. Lett Appl Microbiol 2009; 49 (6): 695–701.
11. Tacket C, Sztein M, Losonsky G et al. Humoral, mucosal, and cellular immune responses to oral Norwalk virus-like particles in volunteers. Clin Immunol 2003; 108 (3): 241–7.
12. Van der Waaij D. Evidence of immunoregulation of comporetion of intestinal microflora and itspractica on seguences. Eur J Clin Microbiol 1988; 7 (1): 101–6.
13. Szajewska H, Skórka A, Ruszczyński M et al. Meta-analysis: Lactobacillus GG for treating acute gastroenteritis in children – updated analysis of randomised controlled trials. Aliment Pharmacol Ther 2013; 38: 467–76.
14. Collado MC, Meriluoto J, Salminen S. Role of commercial probiotic strains against human pathogen adhesion to intestinal mucus. Lett Appl Microbiol 2007; 45: 454–60.
15. Hutsko SL, Meizlisch K, Wick M, Lilburn MS. Early intestinal development and mucin transcription in the young poult with probiotic and mannan oligosaccharide prebiotic supplementation. Poult Sci 2016; 95 (5): 1173–8. DOI: 10.3382/ps/pew019
16. Olson JK, Rager TM, Navarro JB et al. Harvesting the benefits of biofilms: A novel probiotic delivery system for the prevention of necrotizing enterocolitis. J Pediatr Surg 2016; 51 (6): 936–41. DOI: 10.1016/j.jpedsurg.2016.02.062
17. Mulder J, Wels M, Kuipers OP et al. Unleashing natural competence in Lactococcus lactis by induction of the competence regulator ComX. Appl Environ Microbiol 2017 Aug 4. pii: AEM.01320-17. DOI: 10.1128/AEM.01320-17
18. Плоскирева А.А., Тхакушинова Н.Х., Горелов А.В. Результаты сравнительного исследования по оценке эффективности и безопасности пробиотиков в стартовой терапии острых кишечных инфекций вирусной этиологии у детей. Инфекционные болезни. 2013; 11 (1): 50–5. / Ploskireva A.A., Tkhakushinova N.Kh., Gorelov A.V. Rezul'taty sravnitel'nogo issledovaniia po otsenke effektivnosti i bezopasnosti probiotikov v startovoi terapii ostrykh kishechnykh infektsii virusnoi etiologii u detei. Infektsionnye bolezni. 2013; 11 (1): 50–5. [in Russian]
19. Szajewska H. Use of Probiotics for Management of Acute Gastroenteritis: A Position Paper by the ESPGHAN Working Group for Probiotics and Prebiotics. JPGN 2014; 55 (4): 531–9.
20. Szajewska H, Guarino A, Hojsak I et al. Use of probiotics for management of acute gastroenteritis: a position paper by the ESPGHAN Working Group for Probiotics and Prebiotics. J Pediatr Gastroenterol Nutr 2014; 58 (4): 531–9.
21. Shenderov BA. Probiotic (symbiotic) bacterial languages. Anaerobe 2011; 17 (6): 490–5.
22. Дышлюк Л.С., Кригер О.В., Милентьева И.С. и др. Введение в направление. Биотехнология: учебное пособие. Кемерово: КемТИПП, 2014. / Dyshliuk L.S., Kriger O.V., Milent'eva I.S. i dr. Vvedenie v napravlenie. Biotekhnologiia: uchebnoe posobie. Kemerovo: KemTIPP, 2014. [in Russian]
23. Ардатская М.Д. Клиническое значение короткоцепочечных жирных кислот при патологии желудочно-кишечного тракта. Дис. ... д-ра мед. наук. М.: 2003. / Ardatskaia M.D. Klinicheskoe znachenie korotkotsepochechnykh zhirnykh kislot pri patologii zheludochno-kishechnogo trakta. Dis. ... d-ra med. nauk. M.: 2003. [in Russian]
24. Коровина Н.А., Захарова И.Н., Малова Н.Е. и др. Роль пребиотиков и пробиотиков в функциональном питании детей. Лечащий врач. 2005; 2: 46–52. / Korovina N.A., Zakharova I.N., Malova N.E. i dr. Rol' prebiotikov i probiotikov v funktsional'nom pitanii detei. Lechashchii vrach. 2005; 2: 46–52. [in Russian]
25. http://www.grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=c1bb445d-bc9a-4520-a2fd- 9b17dd6ede87&t=93f52b8c-d199-4410-ac57-7bd49b8a1dbd.
________________________________________________
2. Allen SJ, Martinez EG, Gregorio GV et al. Probiotics for treating acute infectious diarrhoea. Cochrane Database Syst Rev 2010; CD003048.
3. Martins FS, Silva AA, Vieira AT et al. Comparative study of Bifidobacterium animalis,
Escherichia coli, Lactobacillus casei and Saccharomyces boulardii probiotic properties. Arch Microbiol 2009; 191: 623–30.
4. Quigley EM. Gut microbiota and the role of probiotics in therapy. Curr Opin Pharmacol 2011; 11 (6): 593–603.
5. Sekirov I, Russell SL, Antunes LC, Finlay BB. Gut Microbiota in Health and Disease Physiol Rev 2010; 90 (3): 859–904.
6. Fons M, Gomez A, Karjalainen T. Mechanisms of colonization and colonization resistance of the digestive tract. Microbial Ecol Health Dis (Suppl.) 2000; 2: 240–6.
7. Reid G. Probiotics: definition, scope and mechanisms of action. Best Pract Res Clin Gastroenterol 2016; 30 (1): 17–25. DOI: 10.1016/j.bpg.2015.12.001
8. Shenderov BA. Metabiotics: novel idea or natural development of probiotic conception. MicrobEcol Health Dis 2013; 24: 20399. http://dx.doi.org/10.3402/mehd.v24i0.20399.
9. Ursova N.I. Bazovye funktsii kishechnoi mikroflory i formirovanie mikrobiotsenoza u detei. Taktika pediatra. 2006; 3: 30–7. [in Russian]
10. Laparra JM, Sanz Y. Comparison of in vitro models to study bacterial adhesion to the intestinal epithelium. Lett Appl Microbiol 2009; 49 (6): 695–701.
11. Tacket C, Sztein M, Losonsky G et al. Humoral, mucosal, and cellular immune responses to oral Norwalk virus-like particles in volunteers. Clin Immunol 2003; 108 (3): 241–7.
12. Van der Waaij D. Evidence of immunoregulation of comporetion of intestinal microflora and itspractica on seguences. Eur J Clin Microbiol 1988; 7 (1): 101–6.
13. Szajewska H, Skórka A, Ruszczyński M et al. Meta-analysis: Lactobacillus GG for treating acute gastroenteritis in children – updated analysis of randomised controlled trials. Aliment Pharmacol Ther 2013; 38: 467–76.
14. Collado MC, Meriluoto J, Salminen S. Role of commercial probiotic strains against human pathogen adhesion to intestinal mucus. Lett Appl Microbiol 2007; 45: 454–60.
15. Hutsko SL, Meizlisch K, Wick M, Lilburn MS. Early intestinal development and mucin transcription in the young poult with probiotic and mannan oligosaccharide prebiotic supplementation. Poult Sci 2016; 95 (5): 1173–8. DOI: 10.3382/ps/pew019
16. Olson JK, Rager TM, Navarro JB et al. Harvesting the benefits of biofilms: A novel probiotic delivery system for the prevention of necrotizing enterocolitis. J Pediatr Surg 2016; 51 (6): 936–41. DOI: 10.1016/j.jpedsurg.2016.02.062
17. Mulder J, Wels M, Kuipers OP et al. Unleashing natural competence in Lactococcus lactis by induction of the competence regulator ComX. Appl Environ Microbiol 2017 Aug 4. pii: AEM.01320-17. DOI: 10.1128/AEM.01320-17
18. Ploskireva A.A., Tkhakushinova N.Kh., Gorelov A.V. Rezul'taty sravnitel'nogo issledovaniia po otsenke effektivnosti i bezopasnosti probiotikov v startovoi terapii ostrykh kishechnykh infektsii virusnoi etiologii u detei. Infektsionnye bolezni. 2013; 11 (1): 50–5. [in Russian]
19. Szajewska H. Use of Probiotics for Management of Acute Gastroenteritis: A Position Paper by the ESPGHAN Working Group for Probiotics and Prebiotics. JPGN 2014; 55 (4): 531–9.
20. Szajewska H, Guarino A, Hojsak I et al. Use of probiotics for management of acute gastroenteritis: a position paper by the ESPGHAN Working Group for Probiotics and Prebiotics. J Pediatr Gastroenterol Nutr 2014; 58 (4): 531–9.
21. Shenderov BA. Probiotic (symbiotic) bacterial languages. Anaerobe 2011; 17 (6): 490–5.
22. Dyshliuk L.S., Kriger O.V., Milent'eva I.S. i dr. Vvedenie v napravlenie. Biotekhnologiia: uchebnoe posobie. Kemerovo: KemTIPP, 2014. [in Russian]
23. Ardatskaia M.D. Klinicheskoe znachenie korotkotsepochechnykh zhirnykh kislot pri patologii zheludochno-kishechnogo trakta. Dis. ... d-ra med. nauk. M.: 2003. [in Russian]
24. Korovina N.A., Zakharova I.N., Malova N.E. i dr. Rol' prebiotikov i probiotikov v funktsional'nom pitanii detei. Lechashchii vrach. 2005; 2: 46–52. [in Russian]
25. http://www.grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=c1bb445d-bc9a-4520-a2fd- 9b17dd6ede87&t=93f52b8c-d199-4410-ac57-7bd49b8a1dbd.
Авторы
А.А.Плоскирева*
ФБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора. 111123, Россия, Москва, ул. Новогиреевская, д. 3а
*antoninna@mail.ru
Central Research Institute of Epidemiology of The Federal Service on Customers' Rights Protection and Human Well-being Surveillance. 111123, Russian Federation, Moscow, ul. Novogireevskaia, d. 3a
*antoninna@mail.ru
ФБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора. 111123, Россия, Москва, ул. Новогиреевская, д. 3а
*antoninna@mail.ru
________________________________________________
Central Research Institute of Epidemiology of The Federal Service on Customers' Rights Protection and Human Well-being Surveillance. 111123, Russian Federation, Moscow, ul. Novogireevskaia, d. 3a
*antoninna@mail.ru
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